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    Viral exanthems: An update on laboratory testing of the adult patient.
    J Am Acad Dermatol 2017 Mar 26;76(3):538-550. Epub 2016 Oct 26.
    Division of Dermatology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, Ohio. Electronic address:
    Although classic viral exanthems of childhood are well described, they are rarely differentiated in adults. Laboratory techniques for viral identification have advanced without substantial literature to suggest how a dermatologist ought to conduct a cost-effective and diagnostic viral panel. Certain clinical features such as petechiae, vesicles, and dusky macular or morbilliform exanthems point strongly toward a viral exanthem. Read More

    Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis.
    Biochem Biophys Res Commun 2017 May 22;486(3):706-711. Epub 2017 Mar 22.
    Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
    Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis. We detected higher levels of interleukin (IL)-1β and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid (CFS) of patients with HHV-6B encephalitis when compared to those in patients with non-HHV-6B-induced febrile seizures. Read More

    Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia.
    Case Rep Pediatr 2016 17;2016:2483183. Epub 2016 Nov 17.
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia.
    We present an infant with acute fever, thrombocytopenia, and leukopenia, coming from an endemic region for tick-borne encephalitis, human granulocytic anaplasmosis, and hantavirus infection. The primary human herpesvirus 6 infection was diagnosed by seroconversion of specific IgM and IgG and by identification of viral DNA in the acute patient's serum. The patient did not show skin rash suggestive of exanthema subitum during the course of illness. Read More

    Cytokine and cellular responses to human herpesvirus-6B in patients with B-acute lymphoblastic leukemia.
    Microbiol Immunol 2016 Nov;60(11):770-777
    Laboratory of Transmissible Diseases and Biological Active Substances, LR99ES27, Faculty of Pharmacy, University of Monastir, Street Avicenne 5000, Monastir, Tunisia.
    Primary infection with human herpesvirus-6 (HHV-6), is followed by its lifelong persistence in the host. Most T-cell responses to HHV-6 have been characterized using peripheral blood from healthy adults; however, the role of HHV-6 infection in immune modulation has not been elucidated for some diseases. Therefore, in this study the immune response to HHV-6 infection in patients with B-acute lymphoblastic leukemia (B-ALL) was analyzed. Read More

    Update on infections with human herpesviruses 6A, 6B, and 7.
    Med Mal Infect 2017 Mar 20;47(2):83-91. Epub 2016 Oct 20.
    Service de virologie, CERVI, hôpitaux universitaires La Pitié Salpêtrière-Charles-Foix, Assistance publique-Hôpitaux de Paris, 83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Inserm, CIMI-Paris UMR 1135, Équipe 1 PVI, Sorbonne universités, UPMC université Paris 6, 75013 Paris, France; Faculté de pharmacie, université Paris-Descartes, 75006 Paris, France. Electronic address:
    Human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, HHV-7) are genetically related to cytomegalovirus. They belong to the Roseolovirus genus and to the Betaherpesvirinae subfamily. They infect T cells, monocytes-macrophages, epithelial cells, and central nervous system cells. Read More

    Monitoring of human herpesviruses-6 and -7 DNA in saliva samples during the acute and convalescent phases of exanthem subitum.
    J Med Virol 2017 Apr 27;89(4):696-702. Epub 2016 Sep 27.
    Departments of Virology and Pediatrics, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
    The amounts of the DNAs of human herpesviruses-6 (HHV-6) and -7 (HHV-7) in saliva samples were monitored during the acute and convalescent phases of exanthem subitum (ES) to elucidate the kinetics of virus shedding after ES. A total of 247 saliva samples were collected from 17 children (5 males and 12 females: 8-31 months old at onset). The monitoring period ranged from 152 to 721 days after onset, and in 15 children it was longer than 1 year. Read More

    Human Herpesviruses 6A, 6B, and 7.
    Microbiol Spectr 2016 Jun;4(3)
    Human roseoloviruses include three different species, human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, HHV-7), genetically related to human cytomegalovirus. They exhibit a wide cell tropism in vivo and, like other herpesviruses, induce a lifelong latent infection in humans. In about 1% of the general population, HHV-6 DNA is covalently integrated into the subtelomeric region of cell chromosomes (ciHHV-6). Read More

    Management of Psychotropic Drug-Induced DRESS Syndrome: A Systematic Review.
    Mayo Clin Proc 2016 Jun 25;91(6):787-801. Epub 2016 Apr 25.
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
    Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous eruption that has been linked to several common drugs and drug categories, including antiepileptics, allopurinol, sulfonamides, and various antibiotics; however, because of a number of recent case reports linking psychotropic medications to this condition, DRESS is increasingly recognized among psychiatrists. We systematically reviewed all psychotropic drugs linked to DRESS syndrome, and this article summarizes the clinical management relevant to psychiatric professionals. A comprehensive search was performed using Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus, and Litt's Drug Eruption and Reaction Database for articles published in English during the past 20 years (1996-2015) using the search terms (1) psychotropic drugs OR serotonin uptake inhibitors AND DRESS or (2) psychotropic drugs AND drug reaction (or rash) eosinophilia systemic syndrome, and all article abstracts were screened for inclusion and exclusion criteria by 3 reviewers. Read More

    Exanthem subitum (human herpesvirus-6 reactivation) after autologous stem cell transplantation.
    Transpl Infect Dis 2016 Apr;18(2):255-6
    Section of Hematology/Oncology, Department of Internal Medicine III, University of Bonn, Bonn, Germany.
    We present the case of a 62-year-old man treated with high-dose chemotherapy and consecutive autologous stem cell transplantation for mantle cell lymphoma, who developed high fever and a rash of the trunk and both axillae 10 days after stem cell transplantation. Read More

    Focal Coxsackie virus B5 encephalitis with synchronous seizure cluster and eruption: Infantile case.
    Pediatr Int 2016 May 29;58(5):415-417. Epub 2015 Dec 29.
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Enterovirus focal encephalitis is a rare clinical entity that is characterized by focal neurological signs including seizure, hemiparesis, hemichorea, and headache, which are mainly followed by rapid spontaneous improvement. We herein describe the case of a 9-month-old boy who developed Coxsackie virus B5 (CVB5) focal encephalitis with seizure clusters in the eruption stage of roseola infantum-like illness, which were followed by rapid improvement and benign outcome. Lumbar puncture indicated pleocytosis, and CVB5 infection in the cerebrospinal fluid was subsequently identified on genome sequencing and virus isolation. Read More

    Predicting the characteristics of the aetiological agent for Kawasaki disease from other paediatric infectious diseases in Japan.
    Epidemiol Infect 2016 Feb 23;144(3):478-92. Epub 2015 Jul 23.
    Institute of Industrial Science,the University of Tokyo,Komaba,Meguro,Tokyo,Japan.
    Although Kawasaki disease (KD), which was first reported in the 1960s, is assumed to be infectious, its aetiological agent(s) remains unknown. We compared the geographical distribution of the force of infection and the super-annual periodicity of KD and seven other paediatric infectious diseases in Japan. The geographical distribution of the force of infection, which was estimated as the inverse of the mean patient age, was similar in KD and other paediatric viral infections. Read More

    Laboratory and clinical aspects of human herpesvirus 6 infections.
    Clin Microbiol Rev 2015 Apr;28(2):313-35
    Sorbonne Universités, UPMC, CIMI-Paris UMRS CR7, PVI Team, Paris, France INSERM, CIMI-Paris U1135, PVI Team, Paris, France AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Service de Virologie, Paris, France Université René Descartes, Faculté de Pharmacie, Laboratoire de Microbiologie UPRES EA 4065, Paris, France.
    Human herpesvirus 6 (HHV-6) is a widespread betaherpesvirus which is genetically related to human cytomegalovirus (HCMV) and now encompasses two different species: HHV-6A and HHV-6B. HHV-6 exhibits a wide cell tropism in vivo and, like other herpesviruses, induces a lifelong latent infection in humans. As a noticeable difference with respect to other human herpesviruses, genomic HHV-6 DNA is covalently integrated into the subtelomeric region of cell chromosomes (ciHHV-6) in about 1% of the general population. Read More

    Prevalence of HHV-6 in cerebrospinal fluid of children younger than 2 years of age with febrile convulsion.
    Iran J Microbiol 2014 Apr;6(2):87-90
    Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Background And Objective: Febrile convulsion is a common disorder in children. Viral infections such as human herpes virus 6 (HHV-6) which results in roseola infantum may contribute to developing seizure. The objective of this study was to determine the prevalence of HHV-6 by detecting DNA in cerebrospinal fluid (CSF) of children with febrile convulsion and without any rash of roseola infantum. Read More

    Human herpesvirus-6 infection-associated acute encephalopathy without skin rash.
    Brain Dev 2015 Sep 9;37(8):829-32. Epub 2015 Jan 9.
    Department of Pediatrics, Asahikawa Medical University, Asahikawa 078-8510, Japan.
    Background: Human herpesvirus-6 (HHV-6) is the etiological agent of exanthema subitum-associated encephalopathy, which usually occurs in children younger than 3 years. Brain imaging shows various abnormalities.

    Patient: A previously healthy 4-year-old girl developed acute encephalopathy with clinical features consisting of fever, repetitive seizures, and a disturbance of consciousness. Read More

    Detection of human herpesvirus 6 in cerebrospinal fluid of children with possible encephalitis.
    Jundishapur J Microbiol 2014 Sep 1;7(9):e11821. Epub 2013 Sep 1.
    Pediatrics Medical Center, Tehran University of Medical Sciences, Tehran, IR Iran.
    Background: Encephalitis is swelling and inflammation of brain, usually due to viral infection. Viral encephalitis symptoms could be fever, headache, altered level of consciousness, and seizures.

    Objectives: The aim of this study was detection of human herpesvirus-6 (HHV-6) DNA in cerebrospinal fluid (CSF) of patients with symptoms of possible acute encephalitis and without typical signs or symptoms of roseola infantum, using real-time polymerase chain reaction (PCR). Read More

    Clinical impact of primary infection with roseoloviruses.
    Curr Opin Virol 2014 Dec 14;9:91-6. Epub 2014 Oct 14.
    Division of Infectious Diseases, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA. Electronic address:
    The roseoloviruses, human herpesvirus-6A -6B and -7 (HHV-6A, HHV-6B and HHV-7) cause acute infection, establish latency, and in the case of HHV-6A and HHV-6B, whole virus can integrate into the host chromosome. Primary infection with HHV-6B occurs in nearly all children and was first linked to the clinical syndrome roseola infantum. However, roseolovirus infection results in a spectrum of clinical disease, ranging from asymptomatic infection to acute febrile illnesses with severe neurologic complications and accounts for a significant portion of healthcare utilization by young children. Read More

    Fatal human herpesvirus 6-associated encephalitis in two boys with underlying POLG mitochondrial disorders.
    Pediatr Neurol 2014 Sep 13;51(3):448-52. Epub 2014 Apr 13.
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan. Electronic address:
    Background: Human herpesvirus 6 is a significant cause of the febrile illness roseola infantum in young children. Infection with human herpesvirus 6 typically causes a self-limited febrile illness but occasionally is associated with central nervous system manifestations, including febrile seizures and encephalitis. Host factors associated with severe manifestations of human herpesvirus 6-associated neurological disease remain poorly characterized. Read More

    Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in human herpesvirus-6-infected infants with or without febrile seizures.
    J Infect Chemother 2014 Nov 21;20(11):716-21. Epub 2014 Aug 21.
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.
    Human herpesvirus-6 (HHV-6) is a cause of exanthema subitum and, sometimes, of febrile seizures. However, the pathogenesis of febrile seizures associated with HHV-6 infection remains unclear. We investigated serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels in infants with HHV-6 infection. Read More

    [Case classification in measles surveillance system under the Two-level Logistic Model].
    Zhonghua Liu Xing Bing Xue Za Zhi 2014 Jan;35(1):57-60
    Department of Epidemiology and Biostatistics, West School of Public Health, Sichuan University, Chengdu 610041, China. Email:
    Objective: To study the prevalence rates of Rash and Febrile Illnesses (RFIs) including measles, rubella, scarlet fever, exanthema subitum and the differences among measles and other RFIs to tentatively formulate the logistic regression model through clinical manifestation.

    Methods: All the suspected cases of measles, rubella, scarlet fever, exanthema subitum reported by the county/prefecture lever hospitals at four counties were collected during March 2011 to February 2012. When setting laboratory confirmed measles as dependent variable and existed symptoms as independent variable, a logistic regression model was formulated and optimal operational point (OOP)chosen, according to the ROC curve. Read More

    Roseola infantum and its causal human herpesviruses.
    Int J Dermatol 2014 Apr;53(4):397-403
    Roseola infantum, also known as exanthem subitum or sixth disease, is a generally benign febrile exanthem of infancy. It has a characteristic clinical course of high fever followed by the appearance of an exanthem upon defervescence. Febrile seizures are a frequent complication. Read More

    Copy numbers of telomeric repeat sequences of human herpesvirus 6B in clinical isolates: possibility of mixed infections.
    J Clin Microbiol 2014 Feb 13;52(2):419-24. Epub 2013 Nov 13.
    Department of Clinical Laboratory, Fujita Health University Hospital, Toyoake, Japan.
    In order to determine whether mixed infections of human herpesvirus 6B (HHV-6B) occur in immunocompetent and immunocompromised individuals, we examined the copy numbers of telomeric repeat sequences (TRS) of clinical isolates. In clinical isolates obtained from patients with exanthem subitum caused by primary HHV-6B infection, PCR products with HHV-6B TRS ranging between 400 and 800 bp were amplified. PCR products of various sizes were amplified in four clinical isolates from drug-induced hypersensitivity syndrome (DIHS) patients and 15 isolates from hematopoietic stem cell transplant (HSCT) recipients with HHV-6B reactivation. Read More

    Quantification of two viral transcripts by real time PCR to investigate human herpesvirus type 6 active infection.
    J Clin Virol 2014 Feb 7;59(2):94-9. Epub 2013 Dec 7.
    EA4271, Immunovirology and Genetic Polymorphism, Nantes University, Nantes, France; Virology Laboratory, Nantes University Hospital, Nantes, France. Electronic address:
    Background: Human herpesvirus 6 (HHV-6) causes exanthema subitum and is associated with symptomatic reactivations in immunocompromised patients, particularly after hematopoietic stem cell transplantation. The detection of viral mRNA can help to make the difference between latent, chromosomally integrated and true replicating virus. It can also be a useful tool to investigate viral multiplication in different cell types. Read More

    Case report of drug rash with eosinophilia and systemic symptoms demonstrating human herpesvirus-6 reactivation.
    Pediatr Dermatol 2013 Sep-Oct;30(5):608-13
    Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
    Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe drug-induced hypersensitivity syndrome that presents with diffuse cutaneous eruptions, fever, and multiorgan involvement. Here we present a pediatric case of DRESS complicated by human herpesvirus (HHV)-6 reactivation. After 1 week of sulfasalazine, our patient developed a diffuse morbilliform eruption. Read More

    [A case of dysfibrinogenemia without hemorrhagic diathesis or thromboembolism linked to a new mutation p.H103N in fibrinogen γ chain].
    Ann Biol Clin (Paris) 2013 Jul-Aug;71(4):489-95
    Service d'hématologie biologique, Centre hospitalier universitaire de Nancy, Vandœuvre-les-Nancy, France.
    This work describes a dysfibrinogenemia linked to a new mutation in the gene coding for fibrinogen γ chain. Dysfibrinogenemia was fortuitously discovered in a 9-year old boy consulting for symptoms suggesting meningitis. DNA was extracted from blood, the fibrinogen genes coding for Aα, Bβ and γ chains were sequenced, and compared with consensus sequences. Read More

    Animal models for human herpesvirus 6 infection.
    Front Microbiol 2013 4;4:174. Epub 2013 Jul 4.
    International Center for Infectiology Research, INSERM U1111, CNRS UMR5308, ENS Lyon, University of Lyon 1 Lyon, France.
    Human herpesvirus (HHV)-6A and HHV-6B are two enveloped DNA viruses of β-herpesvirus family, infecting over 90% of the population and associated with several diseases, including exanthema subitum (for HHV-6B), multiple sclerosis and encephalitis, particularly in immunosuppressed patients. Animal models are highly important to better understand the pathogenesis of viral infections. Naturally developed neutralizing antibodies to HHV-6 or a related virus were found in different species of monkeys, suggesting their susceptibility to HHV-6 infection. Read More

    The long-term outcomes of patients transplanted due to acute liver failure with hepatic human herpesvirus-6 infection.
    Transplant Proc 2013 Jun;45(5):1910-2
    Department of Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
    Human herpesvirus (HHV)-6, comprised of HHV-6A and HHV-6B, belongs to the betaherpesviruses that infect 95%-100% of humans. Primary infection, known as exanthema subitum, occurs in early childhood. Reactivations of latent HHV-6, mostly HHV-6B, are common after liver transplantation. Read More

    Long-term epidemiologic longitudinal study on the effect of vaccines on public inoculation.
    Turk J Pediatr 2012 Jul-Aug;54(4):376-81
    Shinshu University Graduate School of Medicine, Matsumoto, Japan.
    Public vaccination policies in Japan for several viruses have achieved favorable results. To accurately evaluate their overall effectiveness, we conducted a 45- year epidemiological survey of measles, varicella and mumps cases at our clinic. The number of patients with measles was found to be significantly decreased with the single-dose vaccination provided at public expense. Read More

    Mapping the telomere integrated genome of human herpesvirus 6A and 6B.
    Virology 2013 Jul 4;442(1):3-11. Epub 2013 May 4.
    Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, FL 33612, United States.
    Human herpesvirus 6B (HHV-6B) is the causative agent of roseola infantum. HHV-6A and 6B can reactivate in immunosuppressed individuals and are linked with severe inflammatory response, organ rejection and central nervous system diseases. About 0. Read More

    Differentiating roseola infantum with pyuria from urinary tract infection.
    Pediatr Int 2013 Apr 27;55(2):214-8. Epub 2013 Feb 27.
    Department of Pediatrics, Cathay General Hospital, Taipei City, Taiwan.
    Background: The aim of this study was to identify factors for differentiating roseola infantum from urinary tract infection (UTI) and to describe a cohort of infants diagnosed with roseola infantum and sterile pyuria.

    Methods: The medical records of infants diagnosed with roseola infantum or UTI were examined. Multivariate analysis was performed to identify factors associated with UTI. Read More

    [Chromosomal integration of the sixth human herpes virus (HHV-6)].
    Epidemiol Mikrobiol Imunol 2012 Sep;61(3):58-66
    Ustav lékarské mikrobiologie 2. lékarské fakulty UK a Fakultní nemocnice v Motole.
    Two closely related and commonly found human herpesviruses HHV-6 A and HHV-6 B are classified into the sixth human herpes virus complex (HHV-6). Primary infection with HHV-6 often takes place in early childhood and it can be either asymptomatic or manifests itself as sixth disease (caused by HHV-6 B). HHV-6 remains present in a latent form in the body with the potential for virus reactivation. Read More

    Human herpes virus type 6 can cause skin lesions at the BCG inoculation site similar to Kawasaki Disease.
    Tohoku J Exp Med 2012 12;228(4):351-3
    Department of Pediatrics, South Miyagi Medical Center, Ogawara, Japan.
    Kawasaki Disease (KD) is acute, febrile, multisystem vasculitis of early childhood, the detailed mechanism of which is still unclear. Skin symptoms occur in KD, such as edema of the hands and feet with subsequent desquamation and redness at the inoculation site of bacillus Calmette-Guerin (BCG). The change at the BCG inoculation site has been considered as a specific feature of KD, although its mechanism is not fully understood. Read More

    Catastrophic Kawasaki disease unresponsive to IVIG in a 3-month-old infant: a diagnostic and therapeutic challenge.
    Pediatr Rheumatol Online J 2012 Aug 28;10(1):28. Epub 2012 Aug 28.
    Graduate Program in Medical Sciences, University of Brasilia School of Medicine, Brasilia, DF, Brazil.
    The present report describes the severe evolution of Kawasaki disease in a three-month-old infant. The ailment was initially atypical in its presentation, with the patient exhibiting only persistent fever in association with a progressive lethargy and maculopapular rash on the face, trunk and limbs erroneously diagnosed as roseola infantum. On the 10th day of the condition, mainly due to the unexplained persistence of fever, the infant was admitted to a local hospital. Read More

    Age-specific sex-related differences in infections: a statistical analysis of national surveillance data in Japan.
    PLoS One 2012 27;7(7):e42261. Epub 2012 Jul 27.
    Department of Biostatistics, Faculty of Medicine, Oita University, Yufu, Oita, Japan.
    Background: To prevent and control infectious diseases, it is important to understand how sex and age influence morbidity rates, but consistent clear descriptions of differences in the reported incidence of infectious diseases in terms of sex and age are sparse.

    Methods And Findings: Data from the Japanese surveillance system for infectious diseases from 2000 to 2009 were used in the analysis of seven viral and four bacterial infectious diseases with relatively large impact on the Japanese community. The male-to-female morbidity (MFM) ratios in different age groups were estimated to compare incidence rates of symptomatic reported infection between the sexes at different ages. Read More

    Development of quantitative RT-PCR assays for detection of three classes of HHV-6B gene transcripts.
    J Med Virol 2012 Sep;84(9):1388-95
    Faculty of Clinical Engineering, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan.
    The monitoring of active human herpesvirus 6 (HHV-6) B infection is important for distinguishing between the reactivation and latent state of the virus. The aim of this present study is to develop a quantitative reverse transcription polymerase chain reaction (RT-PCR) assay for diagnosis of active viral infection. Primers and probes for in house quantitative RT-PCR methods were designed to detect the three kinetic classes of HHV-6B mRNAs (U90, U12, U100). Read More

    Mutations of the SCN1A gene in acute encephalopathy.
    Epilepsia 2012 Mar 6;53(3):558-64. Epub 2012 Feb 6.
    Department of Developmental Medical Sciences, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
    Purpose: Acute encephalopathy is the most serious complication of pediatric viral infections, such as influenza and exanthema subitum. It occurs worldwide, but is most prevalent in East Asia. Recently, there have been sporadic case reports of epilepsy/febrile seizure and acute encephalopathy with a neuronal sodium channel alpha 1 subunit (SCN1A) mutation. Read More

    Simultaneous presence of human herpesvirus 6 and adenovirus infections in intestinal intussusception of young children.
    Acta Paediatr 2012 Jun 21;101(6):663-70. Epub 2012 Feb 21.
    Vaccine Research Center, University of Tampere Medical School, Tampere, Finland.
    Aim: This prospective study investigated the role of viral infections in the pathogenesis of intussusception, including human herpesvirus 6 (HHV-6), a known lymphotropic virus.

    Methods: Fifty-three children with intussusception treated in hospital were enroled, and children of comparable age and gender served as controls. Blood, stool and throat swab specimens, as well as mesenteric lymph nodes and pieces of intestine from patients requiring surgery were tested for various viruses by PCR methods. Read More

    Development of a human herpesvirus 6 species-specific immunoblotting assay.
    J Clin Microbiol 2012 Apr 25;50(4):1245-51. Epub 2012 Jan 25.
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
    In order to assess the full spectrum of human herpesvirus 6A (HHV-6A)- and HHV-6B-associated diseases, we sought to develop an HHV-6 species-specific serological assay based on immunoblot analysis. The immunodominant proteins encoded by open reading frame U11, p100 for HHV-6A (strain U1102) and 101K for HHV-6B (strain Z29), were selected to generate virus species-specific antigens. Recombinant p100 and 101K were produced in a prokaryotic expression system. Read More

    Human herpesvirus 6-associated uveitis with optic neuritis diagnosed by multiplex PCR.
    Jpn J Ophthalmol 2011 Sep 4;55(5):502-5. Epub 2011 Aug 4.
    Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
    Purpose: Human herpesvirus 6 (HHV-6), which is usually responsible for exanthem subitum in children, can be reactivated from its latent state. We report a case of unilateral optic disc edema and retinal vasculitis associated with HHV-6 infection.

    Case: A healthy 63-year-old man noted a decrease in the vision of his left eye. Read More

    [HHV-6 infection and its clinical significance].
    Duodecim 2011 ;127(12):1204-11
    HUSLAB, virologian osasto ja Helsingen yliopisto, PL 400, 00029 HUS.
    Human herpes virus 6 (HHV-6) is a common virus, known as the causative agent of exanthema subitum. In addition, the virus is known for its tropism for the central nervous system and as the causative agent of encephalitides. HHV-6 produces a lifetime latency and may be reactivated during immunosuppression therapy for instance in organ transplantation patients. Read More

    An epidemiological study of children with status epilepticus in Okayama, Japan: incidence, etiologies, and outcomes.
    Epilepsy Res 2011 Sep 7;96(1-2):89-95. Epub 2011 Jul 7.
    Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Shikatacho 2-chome 5-1, Kita-ku, Okayama 700-8558, Japan.
    To clarify the incidence of first-ever episodes of status epilepticus (SE), their etiologies and outcomes among Japanese children, we performed an epidemiological study in Okayama City. One hundred and twenty patients (69 males, 51 females) experienced first-ever SE episodes between 2003 and 2005. Overall, the annual incidence of SE was 42. Read More

    Detection of human herpesvirus 7 infection in young children presenting with exanthema subitum.
    Mem Inst Oswaldo Cruz 2011 May;106(3):371-3
    Laboratório 319, Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, RJ, Brasil.
    In this study, we assessed the prevalence of human herpesvirus-7 (HHV-7) in 141 serum samples from children less than four years of age with exanthematic disease. All samples were negative for measles, rubella, dengue fever and parvovirus B19 infection. Testing for the presence of human herpesvirus-6 (HHV-6)-specific high avidity IgG antibodies by indirect immunofluorescence assay (IFA) revealed two main groups: one composed of 57 patients with recent primary HHV-6 infection and another group of 68 patients showing signs of past HHV-6 infection. Read More

    The DRESS syndrome: a literature review.
    Am J Med 2011 Jul 17;124(7):588-97. Epub 2011 May 17.
    Department of Internal Medicine, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, France.
    The Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug-induced reaction. Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs involved. We used the RegiSCAR scoring system that grades DRESS cases as "no," "possible," "probable," or "definite" to classify cases reported in the literature. Read More

    Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants.
    Food Chem Toxicol 2011 Aug 6;49(8):1843-8. Epub 2011 May 6.
    Norwegian Institute of Public Health, NO-0403 Oslo, Norway.
    The birth cohort BraMat (n = 205; a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health) was established to study whether prenatal exposure to toxicants from the maternal diet affects immunological health outcomes in children. We here report on the environmental pollutants polychlorinated biphenyls (PCBs) and dioxins, as well as acrylamide generated in food during heat treatment. The frequency of common infections, eczema or itchiness, and periods of more than 10 days of dry cough, chest tightness or wheeze (called wheeze) in the children during the first year of life was assessed by questionnaire data (n = 195). Read More

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