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    Chromosomally integrated human herpesvirus 6 in the Japanese population.
    J Med Virol 2018 Jun 15. Epub 2018 Jun 15.
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
    Objectives: To elucidate an incidence and virological findings of chromosomally integrated human herpesvirus 6 (ciHHV-6) in Japanese population and analyzed an association between ciHHV-6 and a clinical manifestation of exanthema subitum (ES).

    Methods: Real-time PCR was performed to determine HHV-6 DNA loads in 2347 cord blood samples from healthy neonates (cohort A), febrile children less than 5 years old (cohort B), and hematopoietic cell transplant recipients (cohort C). CiHHV-6 was confirmed by detection of high copy numbers of viral DNA in somatic cells. Read More
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    Human herpesvirus-6 pneumonitis in a patient with follicular lymphoma following immunochemotherapy with rituximab.
    Infect Drug Resist 2018 14;11:701-705. Epub 2018 May 14.
    Department of Medicine, Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially post-transplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis. Read More
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    Unique cell tropism of HHV-6B in an infantile autopsy case of primary HHV-6B encephalitis.
    Neuropathology 2018 Mar 26. Epub 2018 Mar 26.
    Department of Pediatrics, Oita University Faculty of Medicine, Yufu, Japan.
    Human herpes virus 6 (HHV-6) is known to cause primary encephalitis in the frontal lobes/cerebral hemisphere or reactivated encephalitis in the hippocampus, but the pathogenesis remains unclear. HHV-6B has also been detected in hippocampal samples in patients with mesial temporal lobe epilepsy. A 1 year and 3 months old female, who had been clinically diagnosed with exanthema subitum and febrile convulsion, was found dead on the third day after onset. Read More
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    [Encephalopathy due to human herpesvirus 6 infection as exanthema subitum complication].
    Arch Argent Pediatr 2018 Apr;116(2):e312-e314
    Unidad de Infectología Pediátrica, Hospital Materno-Infantil Miguel Servet, Zaragoza. España.
    The main clinical manifestation of human herpesvirus 6 is exanthema subitum (also known as roseola infantum) and febrile syndrome. Central nervous system manifestations are not unusual in herpesvirus 6 infection, and even though the pathophysiology is not clear, they need to be early diagnosed and treated in order to avoid potentially serious damage. We present the case of an immunocompetent 2-year-old girl with encephalitis as a complication of herpesvirus 6 infection. Read More
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    The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association With Roseola.
    Pediatr Emerg Care 2018 Feb 28. Epub 2018 Feb 28.
    Roseola infantum is a clinical syndrome characterized by high fever followed by the emergence of a rash. Case reports have documented an association between bulging fontanelles and roseola. We propose a novel mechanism for the development of intracranial hypertension caused by human herpesvirus 6-induced cytokine elevation leading to increased cerebrospinal fluid production. Read More
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    Acute Liver Failure in an Adolescent Male Induced by Human Herpesvirus 6 (HHV-6): A Case Report With Literature Review.
    Lab Med 2018 Mar;49(2):165-174
    Department of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, AZ.
    A previously healthy 11-year-old Caucasian boy presented with a 2-week history of nonspecific symptoms of nausea and nonbilious, nonbloody emesis. He developed significant jaundice and hepatic encephalopathy within 1 week of beginning symptoms and was discovered to have fulminant liver failure. Extensive work-ups for underlying etiologies included serologic evaluation for underlying chronic liver diseases, toxicology screening, inborn errors of metabolism, and infectious diseases. Read More
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    Brainstem infarction associated with HHV-6 infection in an infant.
    Brain Dev 2018 Mar 25;40(3):242-246. Epub 2017 Sep 25.
    Department of Pediatrics, Gunma Chuo Hospital, Japan.
    Introduction: The relevant literature includes several case reports on cerebral infarction in children with HHV-6 infection; however, there is no report of brain stem infarction.

    Case: An 11-month-old girl was hospitalized because of fever. She was unable to stand up and meet her mother's gaze. Read More
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    Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult.
    Virol J 2017 05 25;14(1):97. Epub 2017 May 25.
    Department of Microbiology, Hospital General Universitario de Elche, Camino Almazara 11, 03203, Elche, Spain.
    Background: Primary Human herpesvirus-7 (HHV-7) infection usually occurs during childhood and causes several clinical manifestations: mainly exanthem subitum (roseola infantum), followed by a lifelong latent state with possible reactivation in case of immunodeficiency. Nevertheless, some considerably different approaches exist regarding the natural history of HHV-7 and the possible consequences of HHV-7 infection in immunocompetent adults. In particular, little is known about its pathogenic role in central nervous system (CNS) disease in nonimmunosuppressed adults. Read More
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    Viral exanthems: An update on laboratory testing of the adult patient.
    J Am Acad Dermatol 2017 Mar 26;76(3):538-550. Epub 2016 Oct 26.
    Division of Dermatology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, Ohio. Electronic address:
    Although classic viral exanthems of childhood are well described, they are rarely differentiated in adults. Laboratory techniques for viral identification have advanced without substantial literature to suggest how a dermatologist ought to conduct a cost-effective and diagnostic viral panel. Certain clinical features such as petechiae, vesicles, and dusky macular or morbilliform exanthems point strongly toward a viral exanthem. Read More
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    Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis.
    Biochem Biophys Res Commun 2017 05 22;486(3):706-711. Epub 2017 Mar 22.
    Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
    Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis. We detected higher levels of interleukin (IL)-1β and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid (CFS) of patients with HHV-6B encephalitis when compared to those in patients with non-HHV-6B-induced febrile seizures. Read More
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    Human Herpesvirus 6 Infection Presenting as an Acute Febrile Illness Associated with Thrombocytopenia and Leukopenia.
    Case Rep Pediatr 2016 17;2016:2483183. Epub 2016 Nov 17.
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, SI-1000 Ljubljana, Slovenia.
    We present an infant with acute fever, thrombocytopenia, and leukopenia, coming from an endemic region for tick-borne encephalitis, human granulocytic anaplasmosis, and hantavirus infection. The primary human herpesvirus 6 infection was diagnosed by seroconversion of specific IgM and IgG and by identification of viral DNA in the acute patient's serum. The patient did not show skin rash suggestive of exanthema subitum during the course of illness. Read More
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    Cytokine and cellular responses to human herpesvirus-6B in patients with B-acute lymphoblastic leukemia.
    Microbiol Immunol 2016 Nov;60(11):770-777
    Laboratory of Transmissible Diseases and Biological Active Substances, LR99ES27, Faculty of Pharmacy, University of Monastir, Street Avicenne 5000, Monastir, Tunisia.
    Primary infection with human herpesvirus-6 (HHV-6), is followed by its lifelong persistence in the host. Most T-cell responses to HHV-6 have been characterized using peripheral blood from healthy adults; however, the role of HHV-6 infection in immune modulation has not been elucidated for some diseases. Therefore, in this study the immune response to HHV-6 infection in patients with B-acute lymphoblastic leukemia (B-ALL) was analyzed. Read More
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    Update on infections with human herpesviruses 6A, 6B, and 7.
    Med Mal Infect 2017 Mar 20;47(2):83-91. Epub 2016 Oct 20.
    Service de virologie, CERVI, hôpitaux universitaires La Pitié Salpêtrière-Charles-Foix, Assistance publique-Hôpitaux de Paris, 83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Inserm, CIMI-Paris UMR 1135, Équipe 1 PVI, Sorbonne universités, UPMC université Paris 6, 75013 Paris, France; Faculté de pharmacie, université Paris-Descartes, 75006 Paris, France. Electronic address:
    Human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, HHV-7) are genetically related to cytomegalovirus. They belong to the Roseolovirus genus and to the Betaherpesvirinae subfamily. They infect T cells, monocytes-macrophages, epithelial cells, and central nervous system cells. Read More
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    Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome.
    Biol Blood Marrow Transplant 2016 12 30;22(12):2250-2255. Epub 2016 Sep 30.
    Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy. Electronic address:
    Human herpesvirus 6 (HHV-6) is increasingly recognized as a potentially life-threatening pathogen in allogeneic hematopoietic stem cell transplantation (alloSCT). We retrospectively evaluated 54 adult patients who developed positivity to HHV-6 after alloSCT. The median time from alloSCT to HHV-6 reactivation was 34 days. Read More
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    Monitoring of human herpesviruses-6 and -7 DNA in saliva samples during the acute and convalescent phases of exanthem subitum.
    J Med Virol 2017 Apr 27;89(4):696-702. Epub 2016 Sep 27.
    Departments of Virology and Pediatrics, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
    The amounts of the DNAs of human herpesviruses-6 (HHV-6) and -7 (HHV-7) in saliva samples were monitored during the acute and convalescent phases of exanthem subitum (ES) to elucidate the kinetics of virus shedding after ES. A total of 247 saliva samples were collected from 17 children (5 males and 12 females: 8-31 months old at onset). The monitoring period ranged from 152 to 721 days after onset, and in 15 children it was longer than 1 year. Read More
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    Human Herpesviruses 6A, 6B, and 7.
    Microbiol Spectr 2016 06;4(3)
    Human roseoloviruses include three different species, human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, HHV-7), genetically related to human cytomegalovirus. They exhibit a wide cell tropism in vivo and, like other herpesviruses, induce a lifelong latent infection in humans. In about 1% of the general population, HHV-6 DNA is covalently integrated into the subtelomeric region of cell chromosomes (ciHHV-6). Read More
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    Did a then unknown virus, HHV-6/7, give rise to the whooping cough vaccine controversy of the 1970s?
    Epidemiol Infect 2016 10 23;144(14):2927-2930. Epub 2016 Jun 23.
    Oxford,UK.
    During the 1970s there was a gross loss of public confidence in infant diphtheria-tetanus-pertussis (DTP) vaccination in the UK. As well as febrile reactions and convulsions, permanent neurological damage was ascribed to the pertussis component of the vaccine, and those concerns resonated worldwide. The subsequent recognition of human herpes virus 6 (HHV-6) and 7 (HHV-7) as common sources of fever in infancy suggests that they were the main underlying cause of what was reported as DTP constitutional side-effects. Read More
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    Management of Psychotropic Drug-Induced DRESS Syndrome: A Systematic Review.
    Mayo Clin Proc 2016 06 25;91(6):787-801. Epub 2016 Apr 25.
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
    Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous eruption that has been linked to several common drugs and drug categories, including antiepileptics, allopurinol, sulfonamides, and various antibiotics; however, because of a number of recent case reports linking psychotropic medications to this condition, DRESS is increasingly recognized among psychiatrists. We systematically reviewed all psychotropic drugs linked to DRESS syndrome, and this article summarizes the clinical management relevant to psychiatric professionals. A comprehensive search was performed using Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus, and Litt's Drug Eruption and Reaction Database for articles published in English during the past 20 years (1996-2015) using the search terms (1) psychotropic drugs OR serotonin uptake inhibitors AND DRESS or (2) psychotropic drugs AND drug reaction (or rash) eosinophilia systemic syndrome, and all article abstracts were screened for inclusion and exclusion criteria by 3 reviewers. Read More
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    Exanthem subitum (human herpesvirus-6 reactivation) after autologous stem cell transplantation.
    Transpl Infect Dis 2016 Apr;18(2):255-6
    Section of Hematology/Oncology, Department of Internal Medicine III, University of Bonn, Bonn, Germany.
    We present the case of a 62-year-old man treated with high-dose chemotherapy and consecutive autologous stem cell transplantation for mantle cell lymphoma, who developed high fever and a rash of the trunk and both axillae 10 days after stem cell transplantation. Read More
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    Focal Coxsackie virus B5 encephalitis with synchronous seizure cluster and eruption: Infantile case.
    Pediatr Int 2016 May 29;58(5):415-417. Epub 2015 Dec 29.
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Enterovirus focal encephalitis is a rare clinical entity that is characterized by focal neurological signs including seizure, hemiparesis, hemichorea, and headache, which are mainly followed by rapid spontaneous improvement. We herein describe the case of a 9-month-old boy who developed Coxsackie virus B5 (CVB5) focal encephalitis with seizure clusters in the eruption stage of roseola infantum-like illness, which were followed by rapid improvement and benign outcome. Lumbar puncture indicated pleocytosis, and CVB5 infection in the cerebrospinal fluid was subsequently identified on genome sequencing and virus isolation. Read More
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    Predicting the characteristics of the aetiological agent for Kawasaki disease from other paediatric infectious diseases in Japan.
    Epidemiol Infect 2016 Feb 23;144(3):478-92. Epub 2015 Jul 23.
    Institute of Industrial Science,the University of Tokyo,Komaba,Meguro,Tokyo,Japan.
    Although Kawasaki disease (KD), which was first reported in the 1960s, is assumed to be infectious, its aetiological agent(s) remains unknown. We compared the geographical distribution of the force of infection and the super-annual periodicity of KD and seven other paediatric infectious diseases in Japan. The geographical distribution of the force of infection, which was estimated as the inverse of the mean patient age, was similar in KD and other paediatric viral infections. Read More
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    Laboratory and clinical aspects of human herpesvirus 6 infections.
    Clin Microbiol Rev 2015 Apr;28(2):313-35
    Sorbonne Universités, UPMC, CIMI-Paris UMRS CR7, PVI Team, Paris, France INSERM, CIMI-Paris U1135, PVI Team, Paris, France AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Service de Virologie, Paris, France Université René Descartes, Faculté de Pharmacie, Laboratoire de Microbiologie UPRES EA 4065, Paris, France.
    Human herpesvirus 6 (HHV-6) is a widespread betaherpesvirus which is genetically related to human cytomegalovirus (HCMV) and now encompasses two different species: HHV-6A and HHV-6B. HHV-6 exhibits a wide cell tropism in vivo and, like other herpesviruses, induces a lifelong latent infection in humans. As a noticeable difference with respect to other human herpesviruses, genomic HHV-6 DNA is covalently integrated into the subtelomeric region of cell chromosomes (ciHHV-6) in about 1% of the general population. Read More
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    Prevalence of HHV-6 in cerebrospinal fluid of children younger than 2 years of age with febrile convulsion.
    Iran J Microbiol 2014 Apr;6(2):87-90
    Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Background And Objective: Febrile convulsion is a common disorder in children. Viral infections such as human herpes virus 6 (HHV-6) which results in roseola infantum may contribute to developing seizure. The objective of this study was to determine the prevalence of HHV-6 by detecting DNA in cerebrospinal fluid (CSF) of children with febrile convulsion and without any rash of roseola infantum. Read More
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    Human herpesvirus-6 infection-associated acute encephalopathy without skin rash.
    Brain Dev 2015 Sep 9;37(8):829-32. Epub 2015 Jan 9.
    Department of Pediatrics, Asahikawa Medical University, Asahikawa 078-8510, Japan.
    Background: Human herpesvirus-6 (HHV-6) is the etiological agent of exanthema subitum-associated encephalopathy, which usually occurs in children younger than 3 years. Brain imaging shows various abnormalities.

    Patient: A previously healthy 4-year-old girl developed acute encephalopathy with clinical features consisting of fever, repetitive seizures, and a disturbance of consciousness. Read More
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    Detection of human herpesvirus 6 in cerebrospinal fluid of children with possible encephalitis.
    Jundishapur J Microbiol 2014 Sep 1;7(9):e11821. Epub 2013 Sep 1.
    Pediatrics Medical Center, Tehran University of Medical Sciences, Tehran, IR Iran.
    Background: Encephalitis is swelling and inflammation of brain, usually due to viral infection. Viral encephalitis symptoms could be fever, headache, altered level of consciousness, and seizures.

    Objectives: The aim of this study was detection of human herpesvirus-6 (HHV-6) DNA in cerebrospinal fluid (CSF) of patients with symptoms of possible acute encephalitis and without typical signs or symptoms of roseola infantum, using real-time polymerase chain reaction (PCR). Read More
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    Clinical impact of primary infection with roseoloviruses.
    Curr Opin Virol 2014 Dec 14;9:91-6. Epub 2014 Oct 14.
    Division of Infectious Diseases, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 690, Rochester, NY 14642, USA. Electronic address:
    The roseoloviruses, human herpesvirus-6A -6B and -7 (HHV-6A, HHV-6B and HHV-7) cause acute infection, establish latency, and in the case of HHV-6A and HHV-6B, whole virus can integrate into the host chromosome. Primary infection with HHV-6B occurs in nearly all children and was first linked to the clinical syndrome roseola infantum. However, roseolovirus infection results in a spectrum of clinical disease, ranging from asymptomatic infection to acute febrile illnesses with severe neurologic complications and accounts for a significant portion of healthcare utilization by young children. Read More
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    Fatal human herpesvirus 6-associated encephalitis in two boys with underlying POLG mitochondrial disorders.
    Pediatr Neurol 2014 Sep 13;51(3):448-52. Epub 2014 Apr 13.
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan. Electronic address:
    Background: Human herpesvirus 6 is a significant cause of the febrile illness roseola infantum in young children. Infection with human herpesvirus 6 typically causes a self-limited febrile illness but occasionally is associated with central nervous system manifestations, including febrile seizures and encephalitis. Host factors associated with severe manifestations of human herpesvirus 6-associated neurological disease remain poorly characterized. Read More
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    Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in human herpesvirus-6-infected infants with or without febrile seizures.
    J Infect Chemother 2014 Nov 21;20(11):716-21. Epub 2014 Aug 21.
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.
    Human herpesvirus-6 (HHV-6) is a cause of exanthema subitum and, sometimes, of febrile seizures. However, the pathogenesis of febrile seizures associated with HHV-6 infection remains unclear. We investigated serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels in infants with HHV-6 infection. Read More
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    [Case classification in measles surveillance system under the Two-level Logistic Model].
    Zhonghua Liu Xing Bing Xue Za Zhi 2014 Jan;35(1):57-60
    Department of Epidemiology and Biostatistics, West School of Public Health, Sichuan University, Chengdu 610041, China. Email:
    Objective: To study the prevalence rates of Rash and Febrile Illnesses (RFIs) including measles, rubella, scarlet fever, exanthema subitum and the differences among measles and other RFIs to tentatively formulate the logistic regression model through clinical manifestation.

    Methods: All the suspected cases of measles, rubella, scarlet fever, exanthema subitum reported by the county/prefecture lever hospitals at four counties were collected during March 2011 to February 2012. When setting laboratory confirmed measles as dependent variable and existed symptoms as independent variable, a logistic regression model was formulated and optimal operational point (OOP)chosen, according to the ROC curve. Read More
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    Roseola infantum and its causal human herpesviruses.
    Int J Dermatol 2014 Apr;53(4):397-403
    Roseola infantum, also known as exanthem subitum or sixth disease, is a generally benign febrile exanthem of infancy. It has a characteristic clinical course of high fever followed by the appearance of an exanthem upon defervescence. Febrile seizures are a frequent complication. Read More
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    Copy numbers of telomeric repeat sequences of human herpesvirus 6B in clinical isolates: possibility of mixed infections.
    J Clin Microbiol 2014 Feb 13;52(2):419-24. Epub 2013 Nov 13.
    Department of Clinical Laboratory, Fujita Health University Hospital, Toyoake, Japan.
    In order to determine whether mixed infections of human herpesvirus 6B (HHV-6B) occur in immunocompetent and immunocompromised individuals, we examined the copy numbers of telomeric repeat sequences (TRS) of clinical isolates. In clinical isolates obtained from patients with exanthem subitum caused by primary HHV-6B infection, PCR products with HHV-6B TRS ranging between 400 and 800 bp were amplified. PCR products of various sizes were amplified in four clinical isolates from drug-induced hypersensitivity syndrome (DIHS) patients and 15 isolates from hematopoietic stem cell transplant (HSCT) recipients with HHV-6B reactivation. Read More
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    Quantification of two viral transcripts by real time PCR to investigate human herpesvirus type 6 active infection.
    J Clin Virol 2014 Feb 7;59(2):94-9. Epub 2013 Dec 7.
    EA4271, Immunovirology and Genetic Polymorphism, Nantes University, Nantes, France; Virology Laboratory, Nantes University Hospital, Nantes, France. Electronic address:
    Background: Human herpesvirus 6 (HHV-6) causes exanthema subitum and is associated with symptomatic reactivations in immunocompromised patients, particularly after hematopoietic stem cell transplantation. The detection of viral mRNA can help to make the difference between latent, chromosomally integrated and true replicating virus. It can also be a useful tool to investigate viral multiplication in different cell types. Read More
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    Case report of drug rash with eosinophilia and systemic symptoms demonstrating human herpesvirus-6 reactivation.
    Pediatr Dermatol 2013 Sep-Oct;30(5):608-13
    Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
    Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe drug-induced hypersensitivity syndrome that presents with diffuse cutaneous eruptions, fever, and multiorgan involvement. Here we present a pediatric case of DRESS complicated by human herpesvirus (HHV)-6 reactivation. After 1 week of sulfasalazine, our patient developed a diffuse morbilliform eruption. Read More
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    [A case of dysfibrinogenemia without hemorrhagic diathesis or thromboembolism linked to a new mutation p.H103N in fibrinogen γ chain].
    Ann Biol Clin (Paris) 2013 Jul-Aug;71(4):489-95
    Service d'hématologie biologique, Centre hospitalier universitaire de Nancy, Vandœuvre-les-Nancy, France.
    This work describes a dysfibrinogenemia linked to a new mutation in the gene coding for fibrinogen γ chain. Dysfibrinogenemia was fortuitously discovered in a 9-year old boy consulting for symptoms suggesting meningitis. DNA was extracted from blood, the fibrinogen genes coding for Aα, Bβ and γ chains were sequenced, and compared with consensus sequences. Read More
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    Animal models for human herpesvirus 6 infection.
    Front Microbiol 2013 4;4:174. Epub 2013 Jul 4.
    International Center for Infectiology Research, INSERM U1111, CNRS UMR5308, ENS Lyon, University of Lyon 1 Lyon, France.
    Human herpesvirus (HHV)-6A and HHV-6B are two enveloped DNA viruses of β-herpesvirus family, infecting over 90% of the population and associated with several diseases, including exanthema subitum (for HHV-6B), multiple sclerosis and encephalitis, particularly in immunosuppressed patients. Animal models are highly important to better understand the pathogenesis of viral infections. Naturally developed neutralizing antibodies to HHV-6 or a related virus were found in different species of monkeys, suggesting their susceptibility to HHV-6 infection. Read More
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    The long-term outcomes of patients transplanted due to acute liver failure with hepatic human herpesvirus-6 infection.
    Transplant Proc 2013 Jun;45(5):1910-2
    Department of Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
    Human herpesvirus (HHV)-6, comprised of HHV-6A and HHV-6B, belongs to the betaherpesviruses that infect 95%-100% of humans. Primary infection, known as exanthema subitum, occurs in early childhood. Reactivations of latent HHV-6, mostly HHV-6B, are common after liver transplantation. Read More
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    Long-term epidemiologic longitudinal study on the effect of vaccines on public inoculation.
    Turk J Pediatr 2012 Jul-Aug;54(4):376-81
    Shinshu University Graduate School of Medicine, Matsumoto, Japan.
    Public vaccination policies in Japan for several viruses have achieved favorable results. To accurately evaluate their overall effectiveness, we conducted a 45- year epidemiological survey of measles, varicella and mumps cases at our clinic. The number of patients with measles was found to be significantly decreased with the single-dose vaccination provided at public expense. Read More
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    Mapping the telomere integrated genome of human herpesvirus 6A and 6B.
    Virology 2013 Jul 4;442(1):3-11. Epub 2013 May 4.
    Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, FL 33612, United States.
    Human herpesvirus 6B (HHV-6B) is the causative agent of roseola infantum. HHV-6A and 6B can reactivate in immunosuppressed individuals and are linked with severe inflammatory response, organ rejection and central nervous system diseases. About 0. Read More
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    Differentiating roseola infantum with pyuria from urinary tract infection.
    Pediatr Int 2013 Apr 27;55(2):214-8. Epub 2013 Feb 27.
    Department of Pediatrics, Cathay General Hospital, Taipei City, Taiwan.
    Background: The aim of this study was to identify factors for differentiating roseola infantum from urinary tract infection (UTI) and to describe a cohort of infants diagnosed with roseola infantum and sterile pyuria.

    Methods: The medical records of infants diagnosed with roseola infantum or UTI were examined. Multivariate analysis was performed to identify factors associated with UTI. Read More
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    [Chromosomal integration of the sixth human herpes virus (HHV-6)].
    Epidemiol Mikrobiol Imunol 2012 Sep;61(3):58-66
    Ustav lékarské mikrobiologie 2. lékarské fakulty UK a Fakultní nemocnice v Motole.
    Two closely related and commonly found human herpesviruses HHV-6 A and HHV-6 B are classified into the sixth human herpes virus complex (HHV-6). Primary infection with HHV-6 often takes place in early childhood and it can be either asymptomatic or manifests itself as sixth disease (caused by HHV-6 B). HHV-6 remains present in a latent form in the body with the potential for virus reactivation. Read More
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    Human herpes virus type 6 can cause skin lesions at the BCG inoculation site similar to Kawasaki Disease.
    Tohoku J Exp Med 2012 12;228(4):351-3
    Department of Pediatrics, South Miyagi Medical Center, Ogawara, Japan.
    Kawasaki Disease (KD) is acute, febrile, multisystem vasculitis of early childhood, the detailed mechanism of which is still unclear. Skin symptoms occur in KD, such as edema of the hands and feet with subsequent desquamation and redness at the inoculation site of bacillus Calmette-Guerin (BCG). The change at the BCG inoculation site has been considered as a specific feature of KD, although its mechanism is not fully understood. Read More
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    Catastrophic Kawasaki disease unresponsive to IVIG in a 3-month-old infant: a diagnostic and therapeutic challenge.
    Pediatr Rheumatol Online J 2012 Aug 28;10(1):28. Epub 2012 Aug 28.
    Graduate Program in Medical Sciences, University of Brasilia School of Medicine, Brasilia, DF, Brazil.
    The present report describes the severe evolution of Kawasaki disease in a three-month-old infant. The ailment was initially atypical in its presentation, with the patient exhibiting only persistent fever in association with a progressive lethargy and maculopapular rash on the face, trunk and limbs erroneously diagnosed as roseola infantum. On the 10th day of the condition, mainly due to the unexplained persistence of fever, the infant was admitted to a local hospital. Read More
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    Age-specific sex-related differences in infections: a statistical analysis of national surveillance data in Japan.
    PLoS One 2012 27;7(7):e42261. Epub 2012 Jul 27.
    Department of Biostatistics, Faculty of Medicine, Oita University, Yufu, Oita, Japan.
    Background: To prevent and control infectious diseases, it is important to understand how sex and age influence morbidity rates, but consistent clear descriptions of differences in the reported incidence of infectious diseases in terms of sex and age are sparse.

    Methods And Findings: Data from the Japanese surveillance system for infectious diseases from 2000 to 2009 were used in the analysis of seven viral and four bacterial infectious diseases with relatively large impact on the Japanese community. The male-to-female morbidity (MFM) ratios in different age groups were estimated to compare incidence rates of symptomatic reported infection between the sexes at different ages. Read More
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    Development of quantitative RT-PCR assays for detection of three classes of HHV-6B gene transcripts.
    J Med Virol 2012 Sep;84(9):1388-95
    Faculty of Clinical Engineering, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan.
    The monitoring of active human herpesvirus 6 (HHV-6) B infection is important for distinguishing between the reactivation and latent state of the virus. The aim of this present study is to develop a quantitative reverse transcription polymerase chain reaction (RT-PCR) assay for diagnosis of active viral infection. Primers and probes for in house quantitative RT-PCR methods were designed to detect the three kinetic classes of HHV-6B mRNAs (U90, U12, U100). Read More
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