4,644 results match your criteria Rosacea


Frontal Fibrosing Alopecia - a review and a practical guide for clinicians.

Ann Agric Environ Med 2022 Jun 31;29(2):169-184. Epub 2021 Aug 31.

Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

Despite a significant increase in reported cases of frontal fibrosing alopecia (FFA) in literature, discussion about the possible role of environmental factors, instruction for diagnosis and guideline for treatment, are limited. The review aims to provide a detailed synthesis of this condition that could be used by clinicians in their practise. Whether single-centre or multi-centre, studies of more than 60 cases less than 5 years old were mainly taken into consideration. Read More

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Integrative skincare trial of intense pulsed light followed by the phyto corrective mask, phyto corrective gel and resveratrol BE for decreasing post-procedure downtime and improving procedure outcomes in patients with rosacea.

J Cosmet Dermatol 2022 Jun 28. Epub 2022 Jun 28.

Gold Skin Care Center, Tennessee Clinical Research Center, Nashville, TN.

Background: Rosacea is a chronic inflammatory skin condition of varying severity that can significantly impact patient quality of life. Intense pulsed light (IPL) is an established treatment for rosacea-associated telangiectasia, inflammation, and erythema. This study assessed whether application of a phyto-corrective mask, gel, and resveratrol antioxidant serum after IPL treatment can improve outcomes and reduce procedure-related adverse effects. Read More

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[Translated article] Contact Allergy in Patients With Rosacea.

Actas Dermosifiliogr 2022 Jun 10;113(6):T550-T554. Epub 2022 May 10.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain.

Background And Objective: Rosacea is a chronic acneiform skin disorder in which impaired skin barrier function can lead to sensitization to allergens. We aimed to analyze contact allergies in our patients with rosacea.

Material And Methods: Retrospective cohort study of all patients who underwent patch testing in our skin allergy clinic between May 1991 and May 2019. Read More

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Sarecycline Demonstrates Clinical Effectiveness against Staphylococcal Infections and Inflammatory Dermatoses: Evidence for Improving Antibiotic Stewardship in Dermatology.

Antibiotics (Basel) 2022 May 27;11(6). Epub 2022 May 27.

Yale Department of Dermatology, Yale School of Medicine, New Haven, CT 06520, USA.

Tetracycline class antibiotics are widely used for multiple skin diseases, including acne vulgaris, acne rosacea, cutaneous infections, inflammatory dermatoses, and autoimmune blistering disorders. Concerns about antibiotic resistance and protecting the human/host microbiome beg the question whether broad-spectrum tetracyclines such as doxycycline and minocycline should be prescribed at such a high rate by dermatologists when a narrow-spectrum tetracycline derivative, sarecycline, exists. We evaluated the clinical effectiveness of oral sarecycline against cutaneous staphylococcal infections, eyelid stye, and mucous membrane pemphigoid to determine whether sarecycline is a viable option for clinicians to practice improved antibiotic stewardship. Read More

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Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study.

PLoS One 2022 23;17(6):e0270268. Epub 2022 Jun 23.

Dell Laser Consultants, Austin, Texas, United States of America.

Purpose: To compare the safety and efficacy of intense pulsed light (IPL) followed by meibomian gland expression (MGX), against monotherapy of MGX.

Methods: Patients with moderate to severe meibomian gland dysfunction (MGD) were 1:1 randomized to 4 sessions of intense pulse light + MGX at 2-week intervals, or 4 sessions of Sham + MGX at 2-week intervals. Both patients and examiners were blinded to the allocation. Read More

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Dermatology: how to manage rosacea in skin of colour.

Drugs Context 2022 31;11. Epub 2022 May 31.

Division of Dermatology, University of Toronto, Toronto, Canada.

Rosacea is a common inflammatory skin disorder affecting the face. Common cutaneous symptoms include papules, pustules, persistent centrofacial erythema, telangiectasias, recurrent flushing, phymatous changes and a variety of ocular manifestations. Previous epidemiological studies have demonstrated that the incidence of rosacea is much lower in people with darker Fitzpatrick phototypes compared to fair-skinned individuals. Read More

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Celastrol inhibits LL37-induced rosacea by inhibiting Ca/CaMKII-mTOR-NF-κB activation.

Biomed Pharmacother 2022 Jun 16;153:113292. Epub 2022 Jun 16.

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address:

Rosacea is a common chronic facial inflammatory disease that affects millions of people worldwide. Due to the unclear etiology of rosacea, effective treatments are limited. Celastrol, a plant-derived triterpene, has been reported to alleviate inflammation in various diseases. Read More

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Perialar intertrigo in children and adolescents: A multicenter prospective study of 41 cases.

Pediatr Dermatol 2022 Jun 14. Epub 2022 Jun 14.

Department of Dermatology-Venereology, Hôpital Archet 2, CHU de Nice, Nice, France.

Background/objectives: We observed isolated cases of perialar intertrigo in children and teenagers that did not appear to correspond to any known clinical entity. The objective of this study was to describe the clinical features of this dermatosis and the clinical characteristics of the patients.

Methods: We conducted a prospective, multicenter cohort study in France from August 2017 to November 2019. Read More

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Serum Level of Brain-Derived Neurotrophic Factor (BDNF) Associated with Depression in Patients with Rosacea: A Candidate Predictive Biomarker.

Clin Cosmet Investig Dermatol 2022 2;15:1029-1036. Epub 2022 Jun 2.

Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China.

Background: The biomarker to predict the depression in patients with rosacea was absent.

Objective: We aimed to explore the potential association between BDNF and depression in patients with rosacea, and also to determine whether serum BDNF level is a potential biomarker for identifying depression in patients with rosacea.

Methods: The patients with rosacea, rosacea with depression and healthy control were included, clinical evaluation (DLQI, RSSs, BDI-II) and serum BDNF levels detection were performed on subjects, the comparisons and correlation analysis of the obtained data were performed. Read More

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Improving Rosacea Outcomes in Skin of Color Patients: A Review on the Nuances in the Treatment and the Use of Cleansers and Moisturizers.

J Drugs Dermatol 2022 Jun;21(6):574-580

Background: While rosacea is a common inflammatory condition that affects diverse populations, published data in skin of color (SOC) are limited. This review explored nuances in clinical presentation and treatment considerations in SOC patients with rosacea and the role of cleansers and moisturizers in the management of rosacea in these populations.

Methods: A panel reviewed and discussed aspects of rosacea in SOC and possible implications for treatment and maintenance. Read More

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Seed Germination Response and Tolerance to Different Abiotic Stresses of Four Species Growing in an Arid Environment.

Front Plant Sci 2022 19;13:892667. Epub 2022 May 19.

State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, China.

Land degradation caused by soil salinization and wind erosion is the major obstruction to sustainable agriculture in the arid region. species have the potential to prevent land degradation. However, there is limited information about seed germination requirements and tolerance to salinity and drought for representative species. Read More

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Uses of eye drops in dermatology, literature review.

J Dermatolog Treat 2022 Jun 2:1-13. Epub 2022 Jun 2.

Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Since medication absorption through the skin and eye tissue seems similar, commercially available eye-drops could be used to treat skin diseases when topical therapies are unavailable or unaffordable. The FDA-approved and off-label applications of various eye drops used as topical treatments in dermatological clinical practice were highlighted in this review. A thorough PubMed and Google Scholar library search using various combinations of the keywords (Eye drop, ocular solution, conjunctival installation, and skin diseases, topical, local, beta-blockers, prostaglandin, cyclosporin, apraclonidine, atropine, oxymetazoline). Read More

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Novel detection method involving non-invasive sebum collection and next-generation sequencing.

Postepy Dermatol Alergol 2022 Apr 16;39(2):321-326. Epub 2021 Jul 16.

Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.

Introduction: mites are common human ectoparasites found across a broad geographical range. They reside in pilosebaceous units of the skin and feed on sebum, epithelial and glandular cells. is the more common mite, inhabiting the upper end of the pilosebaceous unit while resides deeper in the skin and meibomian glands. Read More

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Rosacea Fulminans in Pregnancy.

Actas Dermosifiliogr 2022 04 26;113(4):435-438. Epub 2021 Jul 26.

Servicio de Dermatología, Hospital Univsersitari Sagrat Cor, Grupo Quirónsalud, Barcelona, España.

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Role of MrgprB2 in Rosacea-Like Inflammation in Mice: Modulation by β-Arrestin 2.

J Invest Dermatol 2022 May 26. Epub 2022 May 26.

Department of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

Cathelicidin LL-37‒mediated activation of mast cells (MCs) has been implicated in the pathogenesis of rosacea, but the receptor involved and the mechanism of its activation and regulation remain unknown. We found that skin biopsies from patients with rosacea display higher frequencies of MCs expressing MRGPRX2 (mouse counterpart MrgprB2) than normal skin. Intradermal injection of LL-37 in wild-type mice resulted in MC recruitment, expression of inflammatory mediators, and development of rosacea-like inflammation. Read More

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Identifying the neural basis for rosacea using positron emission tomography-computed tomography cerebral functional imaging analysis: A cross-sectional study.

Skin Res Technol 2022 May 29. Epub 2022 May 29.

Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: The neural basis of rosacea is not well understood. This study aimed to determine whether cerebral glucose metabolism (CGM) changes on F-fluorodeoxyglucose ( F-FDG) positron emission tomography (PET)/computed tomography (CT) scans can detect functional network changes in specific brain areas in patients with rosacea.

Materials And Methods: Eight adults with rosacea and 10 age/sex-matched healthy adults (controls) were enrolled in the study. Read More

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Enhancing Topical Pharmacotherapy for Acne and Rosacea: Vehicle Choices and Outcomes.

J Clin Aesthet Dermatol 2022 May;15(5):36-40

Mr. Prunty and Dr. Rhoades are with AraMed Strategies, LLC, in Middletown, Delaware, and Steamboat Springs, Colorado, respectively.

The choice of vehicle is an important consideration in the treatment of acne and rosacea. Agents used to treat these common conditions may be limited by multiple factors, including poor stability during storage, limited residence time in the skin and follicular unit, and high potential for skin irritation. Novel drug delivery systems have been developed to address these problems, including microencapsulation, liposomal encapsulation, and the use of a variety of nanocarriers. Read More

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Off-Label Use of Botulinum Toxin in Dermatology-Current State of the Art.

Molecules 2022 May 13;27(10). Epub 2022 May 13.

Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.

Botulinum toxin (BoNT) is a neurotoxin produced by the bacteria. Among seven different isoforms, only BoNT-A and BoNT-B are commercially used. Currently, botulinum toxin has been indicated by the U. Read More

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Combination of Specific Vascular Lasers and Vascular Intense Pulsed Light Improves Facial Telangiectasias and Redness.

Medicina (Kaunas) 2022 May 11;58(5). Epub 2022 May 11.

Department of Systems Medicine, Tor Vergata University, 00100 Rome, Italy.

Facial telangiectasias are dilated blood vessels that can represent a cosmetic issue for patients. They may be associated with other conditions, such as rosacea. Laser and light treatments are nowadays becoming a cornerstone in the management of these lesions. Read More

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The Trinity of Skin: Skin Homeostasis as a Neuro-Endocrine-Immune Organ.

Life (Basel) 2022 May 12;12(5). Epub 2022 May 12.

Department of Dermatology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

For a long time, skin was thought to be no more than the barrier of our body. However, in the last few decades, studies into the idea of skin as an independent functional organ have gradually deepened our understanding of skin and its functions. In this review, we gathered evidence that presented skin as a "trinity" of neuro-endocrine-immune function. Read More

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Gut-Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis.

Biomedicines 2022 Apr 30;10(5). Epub 2022 Apr 30.

Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia.

Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health. This is regulated through several mechanisms such as inflammatory mediators and the immune system. Read More

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An Update on the Cosmetic Use of Botulinum Toxin: The Pattern of Practice among Korean Dermatologists.

Toxins (Basel) 2022 05 4;14(5). Epub 2022 May 4.

Korean Society for Anti-Aging Dermatology (KAAD), 385 Seongnam-daero, Seoul 13555, Korea.

The efficacy and safety of botulinum toxin injection have made it a popular aesthetic procedure worldwide. A cross-sectional survey was performed in order to determine the pattern of type A botulinum toxin injections in cosmetic practice, for which an 18-item questionnaire was distributed to dermatologists. A total of 469 Korean board-certified dermatologists participated in the survey, with the following results: the main candidates for type A botulinum toxin injection were individuals in their 40-50 years (46. Read More

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Mediation roles of neutrophils and high-density lipoprotein (HDL) on the relationship between HLA-DQB1 and rosacea.

Ann Med 2022 12;54(1):1530-1537

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Background: Though the previous genome-wide association studies found the association between alleles and rosacea in the European populations, the data is lacking among the Asians. Moreover, neutrophils are important in the immune-related mechanism of rosacea, and dyslipidemia is closely related to rosacea. We aimed to explore the association between genes and rosacea in Chinese rosacea patients, as well as the mediation effect of neutrophils, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) on the relationship between genes and rosacea. Read More

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December 2022

Topical ruxolitinib in the treatment of refractory facial seborrheic dermatitis.

JAAD Case Rep 2022 Jun 23;24:59-60. Epub 2022 Apr 23.

Department of Dermatology, University of Rochester Medical Center, Rochester, New York.

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Clinical clues to identify patients with ocular rosacea - a Germany-wide epidemiologic analysis.

Int J Dermatol 2022 Jul 17;61(7):880-885. Epub 2022 May 17.

Department of Dermatology and Allergy, University Hospital of Munich (LMU), Munich, Germany.

Background And Objectives: Ocular rosacea is a special manifestation of rosacea with unknown etiology. Eye involvement in rosacea patients is surprisingly common; however, it is often underdiagnosed, resulting in inappropriate treatment. We aimed to provide an updated epidemiologic perspective on ocular rosacea in Germany to improve patient care. Read More

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Assessment of hearing loss in patients with rosacea.

J Cosmet Dermatol 2022 May 16. Epub 2022 May 16.

Public Health Expertise, Eskişehir Provincial Health Directorate, Eskişehir, Turkey.

Objectives/aims: Rosacea is not only a skin condition but a systemic inflammatory disease that includes chronic inflammation, vascular alterations, and autoimmunity in pathogenesis. We aimed to evaluate the presence of a sensorineural hearing loss in the patients with rosacea in comparison with the healthy control group and, also to compare the audiometric results according to the severity of disease among the patient group.

Methods: Fifty-three patients with erythematelangiectatic or papulopustular type of rosacea and 105 age- and sex-matched healthy controls were included. Read More

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Recent advances on endogenous gasotransmitters in inflammatory dermatological disorders.

J Adv Res 2022 05 1;38:261-274. Epub 2021 Sep 1.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: Endogenous gasotransmitters are small gaseous mediators that can be generated endogenously by mammalian organisms. The dysregulation of the gasotransmitter system is associated with numerous disorders ranging from inflammatory diseases to cancers. However, the relevance of these endogenous gasotransmitters, prodrug donors and inhibitors in inflammatory dermatological disorders has not yet been thoroughly reviewed and discussed. Read More

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Fucodendropeptides induce changes in cells of the immune system in food allergic patients via DC-SIGN receptor.

Carbohydr Res 2022 Jul 6;517:108580. Epub 2022 May 6.

Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Av. Américo Vespucio 49, Seville, 41092, Spain. Electronic address:

Food allergy induced by lipid transfer proteins (LTPs) of Rosacea fruit family, such as peach, is becoming an important health problem in the Mediterranean area. Current treatments, such as allergen specific immunotherapy (AIT) with allergenic extracts show promising, but in many cases, they need an improvement in homogeneity, availability and induction of tolerant responses. Peptide-based vaccines containing adjuvants, such as carbohydrates for C-type lectin receptors (CLRs) are presented as an alternative approach. Read More

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