3,813 results match your criteria Rosacea


Concerns and Treatment Satisfaction in Patients Being Treated With Azelaic Acid Foam for Rosacea

J Drugs Dermatol 2019 Apr;18(4):381-386

Objective: To describe patient characteristics, concerns, side effects, treatment satisfaction, and quality of life (QoL) of rosacea patients currently being treated with monotherapy azelaic acid foam based on patient-reported data. Methods: The study utilized a non-interventional, prospective, observational design. Patients were recruited in the United States and were eligible if the following criteria were met: diagnosed with rosacea by a medical professional, ≥18 years of age, currently receiving monotherapy with azelaic acid foam, and able to provide informed consent. Read More

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Clinical picture, diagnosis and treatment of rosacea, complicated by mites.

Dermatol Reports 2019 Jan 28;11(1):7675. Epub 2019 Mar 28.

Russian Medical Academy of Continuous Professional Education, Ministry of Healthcare of the Russian Federation, Moscow, Russia.

The article analyzes the clinical picture and course of rosacea in patients with mites. It presents the advantages of using the method of confocal laser scanning microscopy over the method of light microscopy of facial skin scrapes. The aimes were to study the influence of mites on the clinical picture and course of rosacea; to compare laboratory and instrumental diagnostic methods for detecting mites; to evaluate the effectiveness of external therapy aimed at eliminating mites. Read More

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https://www.pagepress.org/journals/index.php/dr/article/view
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http://dx.doi.org/10.4081/dr.2019.7675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452096PMC
January 2019
1 Read

Nanoemulsion strategy of pioglitazone for the treatment of skin inflammatory diseases.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.017DOI Listing
April 2019
1 Read

Nonvascular uses of pulsed dye laser in clinical dermatology.

J Cosmet Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Lasers are fast becoming the vogue of dermatology ranging from ablative, nonablative, fractional photothermolysis to vascular lasers. There are a range of vascular lasers including potassium titanyl phosphate (KTP 532 nm), pulsed dye laser (PDL -595 nm), diode (810 nm), and Nd:YAG (1064 nm). PDL is a laser that emits yellow light using Rhodamine dye as it is lasing medium. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12924
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http://dx.doi.org/10.1111/jocd.12924DOI Listing
April 2019
2 Reads

Evaluation of Demodex mite viability using motility and scattered light intensity.

Exp Appl Acarol 2019 Apr 19. Epub 2019 Apr 19.

Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.

Demodex mites have been suggested to have a role in various cutaneous and ocular disorders pathogenesis, such as rosacea or blepharitis. Evaluation of potential treatments with anti-Demodex effects is difficult because the viability of living mites needs to be evaluated during their exposure to the agent being tested. Mite viability is currently based solely on their observed movement. Read More

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http://dx.doi.org/10.1007/s10493-019-00358-4DOI Listing

Surgical Treatment Strategy for Severe Rhinophyma With Bilateral Pedicled Nasolabial Flaps.

J Craniofac Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Plastic and Reconstructive Surgery, The First Affiliated Hospital of China Medical University, People's Republic of China.

Background: Rhinophyma is a rare disease characterized by chronic inflammation and hypertrophy of sebaceous glands, blood vessels, and fibrous tissue, associated with end-stage severe acne rosacea. There are multiple approaches to treatment and repair, including dermal shaving, secondary intention healing, free skin graft, and skin flaps. However, these methods have various disadvantages, such as prolonged healing, obvious scarring, and skin texture mismatch. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005524DOI Listing

Treatment of Rhinophyma With Surgical Excision and Amniotic Membrane.

J Craniofac Surg 2019 Apr 10. Epub 2019 Apr 10.

DeWitt Daughtry Family Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Miami, Miami, FL.

Rhinophyma is a phenotypic subtype of rosacea affecting the nose. It is characterized by phymatous changes, skin thickening/fibrosis, glandular hyperplasia, and chronic inflammation. Treatment of severe rhinophyma is predominantly surgical excision with closure by secondary intention. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005529DOI Listing
April 2019
4 Reads

Do Dermatologic Diagnosis Change in Hot vs. Cold Periods of The Year? A Sub-Analysis of the DIADERM National Sample (Spain 2016).

Actas Dermosifiliogr 2019 Apr 11. Epub 2019 Apr 11.

Unidad de Investigación. Fundación Piel Sana AEDV, Madrid, España; Departamento de Dermatología. Complejo Hospitalario Universitario de Vigo, Vigo, España.

Background: Knowledge of seasonal variation of cutaneous disorder may be useful for heath planning and disease management. To date, however, descriptions of seasonality including all diagnoses in a representative country sample are very scarce.

Objectives: To evaluate if clinical dermatologic diagnosis in Spain change in the hot vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00017310193009
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http://dx.doi.org/10.1016/j.ad.2019.02.004DOI Listing
April 2019
2 Reads

Abnormal glucocorticoid synthesis in the lesional skin of erythematotelangiectatic rosacea.

J Invest Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Institute of Human-Environmental Interface Biology, Medical Research Center, Seoul National University; Department of Dermatology, Seoul National University Boramae Medical Center. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.02.036DOI Listing

Prevalence of cutaneous comorbidities in psoriatic patients and their impact on quality of life.

Eur J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Dermatology Department, Catholic University of the Sacred Heart, Rome.

In contrast to the evidence for systemic co-morbidities, relatively few studies have examined the prevalence of cutaneous inflammatory co-morbidities in psoriatic patients. We conducted an observational multi-site study to measure the prevalence of cutaneous co-morbidities in adult patients with plaque psoriasis and to assess the relative impact on quality of life (QOL). Each patient attending one of the study clinics over a period of six months was evaluated to assess the presence of any concomitant skin inflammatory disease other than psoriasis at the time of the visit. Read More

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http://dx.doi.org/10.1684/ejd.2019.3529DOI Listing
April 2019
2 Reads

[Teledermatology in Switzerland : Set-up for and examples of dermatological treatment from a telemedicine center].

Hautarzt 2019 Apr 10. Epub 2019 Apr 10.

Medgate AG, Gellertstr. 19, 4020, Basel, Schweiz.

Background And Objectives: In Switzerland, telemedicine has been an integral part of the health care system for many years and plays a significant role in basic medical care. Telemedicine is particularly suitable for skin diseases, thanks to the possibility of diagnostic imaging. The aim of this article is to point to services and structures needed using the example of a successful telemedicine center (Medgate Tele Clinic, Basel, Switzerland) and to illustrate the wide range of applications of telemedicine available in Switzerland based on examples from teledermatology. Read More

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http://dx.doi.org/10.1007/s00105-019-4401-0DOI Listing

Preparation of in situ hydrogels loaded with azelaic acid nanocrystals and their dermal application performance study.

Int J Pharm 2019 Apr 6;563:249-258. Epub 2019 Apr 6.

University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovacica 1, 10000 Zagreb, Croatia. Electronic address:

Azelaic acid (AZA) is a dicarboxylic acid that is topically used in the treatment of acne and rosacea since it possesses antibacterial and keratolytic activity. The primary objective of this study was to develop an AZA nanocrystal suspension. It is expected that improved solubility and dissolution rate will result in advanced biopharmaceutical properties, primarily the dermal bioavailability. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.016DOI Listing
April 2019
1 Read
3.650 Impact Factor

[THE RATIONALE FOR THE POSSIBLE ROLE OF DEMODEX FOLLICULORUM IN THE PATHOGENESIS OF ROSACEA].

Georgian Med News 2019 Feb(287):95-98

Tbilisi Medical University, Department of Dermatology and Venerology, Georgia.

The purpose of the study was to study the frequency of detection and population density of the mite in rosacea patients depending on the clinical form, the location of the morphological elements on the face and some parameters of the functional state of the skin. We observed 55 patients (38 women and 17 men) aged from 30 to 65 years old with disease duration from 6 months to 10 years. According to clinical forms, 35 had PPR and 20 - ETR (erythematous - telangiectatic rosacea). Read More

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February 2019
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Dapsone for Unresponsive Granulomatous Rosacea.

Am J Ther 2019 Apr 1. Epub 2019 Apr 1.

Di.S.Sal. Section of Dermatology, University of Genoa, San Martino Polyclinic Hospital, Genoa, Italy.

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http://dx.doi.org/10.1097/MJT.0000000000000903DOI Listing

A Case Report of Fulminant Type 1 Diabetes Mellitus Caused by Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Complicated by Iodine-Induced Thyrotoxicosis.

Diabetes Ther 2019 Apr 1. Epub 2019 Apr 1.

Department of Endocrinology, Key Laboratory of Endocrinology of National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

A 46-year-old woman presented with rash, fever, lymphadenopathy, eosinophilia and liver dysfunction. She had been treated with ornidazole for facial rosacea 2 months previously. Two weeks following presentation, she developed diabetic ketoacidosis with exhausted beta islets (2 h postprandial laboratory values: glucose 22. Read More

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http://dx.doi.org/10.1007/s13300-019-0607-5DOI Listing
April 2019
2 Reads

Effect of recombinant bovine basic fibroblast growth factor gel on repair of rosacea skin lesions: A randomized, single-blind and vehicle-controlled study.

Exp Ther Med 2019 Apr 12;17(4):2725-2733. Epub 2019 Feb 12.

Department of Dermatology, Lanzhou General Hospital, Lanzhou, Gansu 730050, P.R. China.

The aim of the present study was to assess the effect of topical use of recombinant bovine basic fibroblast growth factor (rbFGF) gel on the repair of facial skin lesions in patients with rosacea. In the present single-blind study, a total of 1,287 patients with mite-induced rosacea who received treatment with ornidazole tablets were randomized to rbFGF gel treatment group (n=651) or control group (n=636) without revealing the group identity. Patients in the treatment group were treated with topical application of rbFGF gel over the skin lesions (0. Read More

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http://dx.doi.org/10.3892/etm.2019.7258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425269PMC
April 2019
5 Reads

Metabolomic variability of four macroalgal species of the genus Lobophora using diverse approaches.

Phytochemistry 2019 Mar 26;162:165-172. Epub 2019 Mar 26.

UMR ENTROPIE (IRD, UR, CNRS), Institut de Recherche pour le Développement, B.P. A5, 98848 Nouméa Cedex, Nouvelle-Calédonie, France. Electronic address:

Among comparative metabolomic studies used in marine sciences, only few of them are dedicated to macroalgae despite their ecological importance in marine ecosystems. Therefore, experimental data are needed to assess the scopes and limitations of different metabolomic techniques applied to macroalgal models. Species of the genus Lobophora belong to marine brown algae (Family: Dictyotaceae) and are widely distributed, especially in tropical coral reefs. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.03.002DOI Listing

Acne and Rosacea: Special Considerations in the Treatment of Patients With Latin American Ancestry

J Drugs Dermatol 2019 Mar;18(3):s124-126

Acne is a common disease among patients with Latin American ancestry. Its presentation is very similar to that in all skin types, but nodulocystic acne is more frequent in patients with oily and darker skin than in white Caucasians. Acne sequelae in patients with Latin American ancestry and with darker skin include postinflammatory hyperpigmentation (PIH) and atrophic and hypertrophic scars or keloids, with PIH being the most common complication affecting the quality of life of patients. Read More

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Treating Acne With Topical Antibiotics: Current Obstacles and the Introduction of Topical Minocycline as a New Treatment Option

J Drugs Dermatol 2019 Mar;18(3):240-244

Oral antibiotics are well established treatments for acne vulgaris but are associated with undesirable side effects. Topical antibiotics offer an improved safety profile but have led to an alarming rise in worldwide P. acnes resistance. Read More

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March 2019
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Rosácea infantil.

Bol Med Hosp Infant Mex 2019 ;76(2):95-99

División de Dermatología y Micología, Hospital General Dr. Manuel Gea González, Ciudad de México. México.

Background: Rosacea is a chronic inflammatory skin condition that usually occurs in adults and rarely has been reported in children, although both subtypes share the same clinical characteristics.

Case Report: A 10-year-old female presented dermostosis on the face, affecting cheeks and nose, characterized by erythema, papules, pustules, scars of two years of evolution, as well as bilateral conjunctivitis, blepharitis and corneal opacity. She referred recurrent exacerbations and partial remission of cutaneous lesions and ocular symptoms related to sun exposure. Read More

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http://dx.doi.org/10.24875/BMHIM.18000032DOI Listing
January 2019
1 Read

Comparative effectiveness of purpuragenic 595 nm pulsed dye laser versus sequential emission of 595 nm pulsed dye laser and 1,064 nm Nd:YAG laser: a double-blind randomized controlled study.

Acta Dermatovenerol Alp Pannonica Adriat 2019 Mar;28(1):1-5

Dermatology Department, Vila Nova de Gaia Central Hospital, Vila Nova da Gaia, Portugal.

Introduction: Erythematotelangiectatic rosacea is a common condition in Caucasians. The most frequently used lasers to treat this condition are pulsed dye laser (PDL) and neodymium:yttrium-aluminum-garnet laser (Nd:YAG). This study compares the treatment efficacy of purpuragenic PDL with that of sequential emission of 595 nm PDL and 1,064 nm Nd:YAG (multiplexed PDL/Nd:YAG). Read More

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March 2019
24 Reads

Skin diseases are more common than we think: screening results of an unreferred population at the Munich Oktoberfest.

J Eur Acad Dermatol Venereol 2019 Mar 19. Epub 2019 Mar 19.

Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.

Background: Skin diseases are ranked as the fourth most common cause of human illness, resulting in an enormous non-fatal burden. Despite this, many affected people do not consult a physician. Accordingly, the actual skin disease burden might be even higher since reported prevalence rates are typically based on secondary data that exclude individuals who do not seek medical care. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15494
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http://dx.doi.org/10.1111/jdv.15494DOI Listing
March 2019
3 Reads

Effective Treatment of Morbihan's Disease with Long-term Isotretinoin: A Report of Three Cases.

J Clin Aesthet Dermatol 2019 Jan 1;12(1):32-34. Epub 2019 Jan 1.

Drs. Olvero-Cortés and Pulido-Díaz are with the Dermatology Department at the Mexican Institute of Social Security and National Medical Center La Raza in Mexico City, Mexico.

Morbihan's disease is characterized by the presence of chronic and persistent edema of the periorbital tissue, forehead, glabella, nose, and cheeks. In some cases, it is related to acne and rosacea, but its exact etiology remains unknown. A defined therapeutic approach has yet to be established for the treatment of Morbihan's disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405251PMC
January 2019

Fractionated Carbon Dioxide Laser Resurfacing as an Ideal Treatment Option for Severe Rhinophyma: A Case Report and Discussion.

J Clin Aesthet Dermatol 2019 Jan 1;12(1):24-27. Epub 2019 Jan 1.

Drs. Comeou, Goodman, and Buckley are with the Department of Dermatology at Philadelphia College of Osteopathic Medicine in Roswell, Georgia.

Rhinophyma is a progressive, disfiguring condition that affects the nose and is caused by the hypertrophy of sebaceous glands and connective tissue. Although its exact pathogenesis remains unclear, it is generally thought to be a subtype of the chronic, inflammatory condition rosacea. To date, oral and topical treatments have been largely ineffective at treating rhinophyma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405248PMC
January 2019

[Ocular and cutaneous rosacea in a child].

Arch Argent Pediatr 2019 Apr;117(2):e170-e172

Servicio de Dermatología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.

Rosacea is a chronic skin disease characterized by erythema, telangiectasia, papules and pustules in the central facial region. It most often affects adults and is rare in children. Rosacea can also present ocular involvement. Read More

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http://dx.doi.org/10.5546/aap.2019.e170DOI Listing
April 2019
2 Reads

[Acne, rosacea, seborrheic dermatitis].

Rev Prat 2018 Oct;68(8):e303-e309

Service de dermatologie, centre hospitalier Victor-Dupouy, 95107 Argenteuil, France.

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October 2018
6 Reads

New indications for topical ivermectin 1% cream: a case series study.

Postepy Dermatol Alergol 2019 Feb 22;36(1):58-62. Epub 2019 Feb 22.

Evimed Medical Center, Warsaw, Poland.

Introduction: Topical ivermectin is an effective treatment for inflammatory papulopustular rosacea in adults. Positive therapeutic effects of ivermectin due to its potential anti-inflammatory properties could be achieved in the other facial dermatoses.

Aim: To assess the efficacy of topical ivermectin 1% cream therapy in mild and moderate perioral dermatitis (PD), seborrheic dermatitis (SD) and acne vulgaris (AV). Read More

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http://dx.doi.org/10.5114/ada.2019.82825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409879PMC
February 2019
2 Reads

Treatment of granulomatous rosacea with chromophore gel-assisted phototherapy.

Photodermatol Photoimmunol Photomed 2019 Mar 10. Epub 2019 Mar 10.

University of New South Wales, Kensington, New South Wales, Australia.

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http://dx.doi.org/10.1111/phpp.12463DOI Listing
March 2019
3 Reads
1.295 Impact Factor

Increased Risk of Cardiovascular Diseases in Female Rosacea Patients: A Nested Case-control Study.

Acta Derm Venereol 2019 Mar 8. Epub 2019 Mar 8.

Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, P.O. Box 20, FIN-90029 Oulu, Finland.

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http://dx.doi.org/10.2340/00015555-3167DOI Listing

Characterization of the Blood Microbiota in Korean Females with Rosacea.

Dermatology 2019 Mar 7:1-5. Epub 2019 Mar 7.

Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea,

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https://www.karger.com/Article/FullText/496968
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http://dx.doi.org/10.1159/000496968DOI Listing
March 2019
1 Read

Rare diseases that mimic Systemic Lupus Erythematosus (Lupus mimickers).

Joint Bone Spine 2019 Mar 26;86(2):165-171. Epub 2018 Oct 26.

Centre national de référence des maladies autoimmunes et systémiques rares Est Sud-Ouest (RESO)-LUPUS, 67000 Strasbourg, France; Service de rhumatologie, hôpitaux universitaires de Strasbourg, 67098 Strasbourg, France; Université de Strasbourg, Inserm UMR-S 1109, 67000 Strasbourg, France. Electronic address:

Several conditions have clinical and laboratory features that can mimic those present in Systemic Lupus Erythematosus (SLE). Some of these "SLE mimickers" are very common, such as rosacea which can be mistaken for the butterfly rash, while others such as Kikuchi disease, type-1 interferonopathies, Castleman's disease, prolidase deficiency, angioimmunoblastic T-cell lymphoma, Evans' syndrome in the context of primary immune deficiencies and the autoimmune lymphoproliferative syndrome are exceptionally uncommon. A proper diagnosis of SLE must therefore be based upon a complete medical history as well as on the adequate constellation of clinical or laboratory findings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183042
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http://dx.doi.org/10.1016/j.jbspin.2018.10.007DOI Listing
March 2019
10 Reads

Spanish Consensus Document on the Treatment Algorithm for Rosacea.

Actas Dermosifiliogr 2019 Mar 2. Epub 2019 Mar 2.

Servicio de Dermatología, Policlínica Gipuzkoa, San Sebastián, España.

Recent scientific evidence and the incorporation of new drugs into the therapeutic arsenal against rosacea have made it necessary to review and update treatment criteria and strategies. To this end, a panel of 15 dermatologists, all experts in rosacea, was formed to share experiences and discuss treatment options, response criteria, and changes to treatment. Based on a critical review of the literature and a discussion of the routine practices of Spanish dermatologists, the panel proposed and debated different options, with consideration of the experience of professionals and the preferences of patients or equality criteria. Read More

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http://dx.doi.org/10.1016/j.ad.2019.01.001DOI Listing

Atrophic acne scar: A process from altered metabolism of elastic fibers and collagen fibers based on TGF-β1 signaling.

Br J Dermatol 2019 Mar 1. Epub 2019 Mar 1.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: Atrophic acne scar, a persistent sequela from acne, is undesirably troubling many patients in cosmetic and psychosocial aspects. Although there have been some reports to emphasize the role of early inflammatory responses in atrophic acne scarring, evolving perspectives on the detailed pathogenic process are promptly needed.

Objectives: Examining the histological, immunological and molecular changes in early acne lesions susceptible to atrophic scarring can provide new insights to understand the pathophysiology of atrophic acne scar. Read More

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http://dx.doi.org/10.1111/bjd.17851DOI Listing
March 2019
1 Read

Idiopathic Facial Aseptic Granuloma: Updated Review of Diagnostic and Therapeutic Difficulties.

Actas Dermosifiliogr 2019 Feb 25. Epub 2019 Feb 25.

Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Instituto de Diagnóstico por Imágenes en Piel y Tejidos Blandos, Departamento de Dermatología, Universidad de Chile y Pontificia Universidad Católica de Chile, Santiago, Chile.

Idiopathic facial aseptic granuloma is a pediatric skin condition involving asymptomatic reddish nodules. The etiology and pathogenesis is still under discussion, although the literature tends to place this condition within the spectrum of childhood rosaceas. The clinical course is chronic but benign, and cases have been reported to resolve spontaneously in less than a year. Read More

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http://dx.doi.org/10.1016/j.ad.2019.01.005DOI Listing
February 2019

Global rosacea treatment guidelines and expert consensus points: The differences.

J Cosmet Dermatol 2019 Feb 26. Epub 2019 Feb 26.

Department of Skin & Cosmetic Research, Shanghai Skin Disease Hospital, Shanghai, China.

Background: Rosacea is a highly prevalent, chronic inflammatory disease. The treatment of rosacea remains a challenge to dermatologists. Therapies include skin care, medications, lasers, and various combinations of these modalities. Read More

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http://dx.doi.org/10.1111/jocd.12903DOI Listing
February 2019
8 Reads

A novel moisturizer with high sun protection factor improves cutaneous barrier function and the visible appearance of rosacea-prone skin.

J Cosmet Dermatol 2019 Feb 25. Epub 2019 Feb 25.

Galderma Research and Development, Sophia Antipolis, France.

Background: Consensus guidelines advocate general skincare for rosacea patients.

Objectives: Two independent studies were performed to assess whether a tinted daily SPF-30 facial moisturizer (DFM30) improves barrier function of dry skin and the efficacy and tolerability of DFM30 on rosacea-prone skin.

Methods: In study 1, electrical capacitance (EC) and transepidermal water loss (TEWL) were measured at baseline, 2, 4, 8, and 24 hours after a single application of DFM30 and on a control site in 21 healthy females with dry skin. Read More

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http://dx.doi.org/10.1111/jocd.12889DOI Listing
February 2019

Epidemiology and Dermatological Comorbidity of Seborrhoeic Dermatitis - Population-based Study in 161,000 Employees.

Br J Dermatol 2019 Feb 25. Epub 2019 Feb 25.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Germany.

Background: Seborrhoeic dermatitis (SD) is a common but epidemiologically poorly researched chronic skin disease.

Objectives: To characterise the prevalence and dermatological comorbidity of SD in Germany.

Methods: In the course of voluntary company skin checks, full body examinations were carried out in more than 500 companies by experienced dermatologists and documented electronically. Read More

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http://dx.doi.org/10.1111/bjd.17826DOI Listing
February 2019
3 Reads

Rosacea fulminans - coincidence of the disease with inflammatory bowel disease.

J Eur Acad Dermatol Venereol 2019 Feb 22. Epub 2019 Feb 22.

Clinic of Dermatology, Venereology and Allergology, Medical University of Gdansk, ul.Kaczencowa 31, Gdynia, 81-575, Poland.

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http://doi.wiley.com/10.1111/jdv.15520
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http://dx.doi.org/10.1111/jdv.15520DOI Listing
February 2019
7 Reads

Unusual case of rosacea fulminans after topical metronidazole application.

Int J Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Dermatology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.

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http://dx.doi.org/10.1111/ijd.14420DOI Listing
February 2019
1 Read

Erythematotelangiectatic rosacea may be associated with a subclinical stage of demodicosis: a case-control study.

Br J Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Free University of Brussels (ULB), Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Service de Biostatistique et Informatique Médicale (SBIM), Route de Lennik 808/CP602, 1070, Brussels, Belgium.

Background: Facial densities of Demodex mites have been observed to be greater in patients with demodicosis and papulopustular rosacea than in healthy control patients. In patients with erythematotelangiectatic rosacea (ETR), this density has been observed to be similar to or greater than that of healthy controls. Erythema and telangiectasia, characteristics of ETR, are often observed among patients with pityriasis folliculorum, a discreet demodicosis, suggesting a possible link between these conditions. Read More

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http://dx.doi.org/10.1111/bjd.17817DOI Listing
February 2019
3 Reads

Natural Skin Care Products as Adjunctive to Prescription Therapy in Moderate to Severe Rosacea

J Drugs Dermatol 2019 02;18(2):141-146

Background: Rosacea is characterized by irritation associated with erythema, telangiectasias and papules/pustules. Whole formula nature-based sensitive skin products are formulated to maintain skin barrier and appropriate hydration that can lead to soothing benefits. Objective: To evaluate the efficacy and tolerability of a regimen consisting of a cleanser containing natural oils, beeswax, and witch hazel and day and night creams containing natural oils, glycerin, and botanical anti-inflammatories (NR); and a synthetic dermatologist-recommended regimen of cetyl alcohol, sodium lauryl sulphate-containing cleanser, and glycerin, polyisobutene-containing lotion (CR) in subjects with rosacea. Read More

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February 2019
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A decade retrospective study of light/laser devices in treating nasal rosacea.

J Dermatolog Treat 2019 Feb 7:1-7. Epub 2019 Feb 7.

a Department of Dermatology , The First Hospital of China Medical University , Shenyang , China.

Background: Large-scale retrospective studies of light/laser in treating nasal rosacea were lacking.

Objective: The study was aimed to perform a decade retrospection of the patients with nasal rosacea who were treated with light/laser devices.

Methods: A study between 2008 and 2017 was performed retrospectively. Read More

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http://dx.doi.org/10.1080/09546634.2019.1580669DOI Listing
February 2019
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Assessment of Skin Physiology Change and Safety After Intradermal Injections With Botulinum Toxin: A Randomized, Double-Blind, Placebo-Controlled, Split-Face Pilot Study in Rosacea Patients With Facial Erythema.

Dermatol Surg 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.

Background: Botulinum toxin (BTX) has been used cosmetically with good clinical efficacy and tolerable safety.

Objective: This randomized, double-blind, split-face clinical study aimed to investigate the efficacy and safety of intradermal BTX in patients with rosacea.

Materials And Methods: Twenty-four participants were enrolled and randomly given intradermal injections of BTX and normal saline in both cheeks. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001819DOI Listing
February 2019
10 Reads

Metronidazole loaded nanostructured lipid carriers to improve skin deposition and retention in the treatment of rosacea.

Drug Dev Ind Pharm 2019 Feb 6:1-30. Epub 2019 Feb 6.

a Department of Pharmaceutics , Bombay College of Pharmacy , Mumbai , India.

The objective of the present investigation was to improve the skin deposition and retention of metronidazole (MTZ) in rosacea therapy, by incorporating it into nanostructured lipid carriers (NLCs). The main challenge in this endeavour was the partial hydrophilicity of MTZ, which mandated careful selection of excipients, including solid and liquid lipids, surfactants, and their ratios in combination. NLCs were produced by the phase inversion temperature method and finally converted into a gel for topical application. Read More

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http://dx.doi.org/10.1080/03639045.2019.1569026DOI Listing
February 2019

Noninvasive assessment of subclinical atherosclerosis in patients with rosacea.

G Ital Dermatol Venereol 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiology, Bozok University School of Medicine, Yozgat, Turkey.

Background: Rosacea is a chronic, inflammatory cutaneous disorder that is characterized by remissions and relapses that commonly occur in patients over the age of 30 years. There have been many studies in literature evaluating the relationship between cardiovascular disease and psoriasis, which is a chronic inflammatory disease, however, there have been very few studies to date evaluating the relationship between rosacea and cardiovascular disease risk.

Methods: The study included 52 consecutive rosacea patients and 52 healthy controls matched for age, gender and body mass index. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06218-7DOI Listing
February 2019
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Claudin reduction may relate to an impaired skin barrier in rosacea.

J Dermatol 2019 Apr 4;46(4):314-321. Epub 2019 Feb 4.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Rosacea is a chronic inflammatory skin disorder whose pathophysiological mechanism remains largely unknown. Although recent studies have revealed the hypersensitivity of the skin towards chemical, thermal and biological stimuli, there is no direct molecular evidence suggesting the skin barrier is impaired in rosacea. In this study, we demonstrated that the mRNA levels of most claudins (CLDN), the main components of tight junctions determining the major barrier of the paracellular pathway between epithelial cells, were lowered in lesional skin of rosacea patients, especially with erythematotelangiectatic (ETR) and papulopustular (PPR) subtypes. Read More

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http://dx.doi.org/10.1111/1346-8138.14792DOI Listing
April 2019
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Severe Rhinophyma. Tips and Tricks in Carbon Dioxide Laser Decortication.

J Am Acad Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Dermatology Department, Complejo Asistencial Universitario de León, Spain.

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http://dx.doi.org/10.1016/j.jaad.2019.01.060DOI Listing
January 2019

The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample.

Clin Exp Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Departments of Dermatology, Preventative Medicine, and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Little is known about the mental health (MH) hospitalization among patients with acne and rosacea.

Aims: To determine the MH disorders and cost burden associated with acne and rosacea.

Methods: Data were examined from the 2002-2012 US National Inpatient Sample, comprising a sample of ~20% of all US paediatric and adult hospitalizations (n = 87 053 155 admissions). Read More

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http://dx.doi.org/10.1111/ced.13919DOI Listing
January 2019
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Nuclear Factor Kappa-B Is Enriched in Eyelid Specimens of Rosacea: Implications for Pathogenesis and Therapy.

Am J Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Department of Molecular and Cellular Physiology, Albany Medical College, Slingerlands, New York, USA.

Purpose: To assess the role of nuclear factor kappa-B (NFKB) in cutaneous specimens of rosacea and unaffected tissue.

Methods: Immunohistochemical staining was performed for the activated, phosphorylated variant of NFKB (pNFKB) in eyelid specimens of rosacea (n = 12) and normal, healthy tissue (n = 12). The numbers of positively staining cells/40× microscopic field were counted across 5 consecutive fields. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.018DOI Listing
January 2019
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A Novel Night Moisturizer Enhances Cutaneous Barrier Function in Dry Skin and Improves Dermatological Outcomes in Rosacea-prone Skin.

J Clin Aesthet Dermatol 2018 Dec 1;11(12):11-17. Epub 2018 Dec 1.

Dr. Santoro is with Galderma Research and Development in Egerkingen, Switzerland.

We assessed whether Cetaphil Redness Control Night Cream (CRCNC; Galderma Laboratories, Fort Worth, Texas) improves electrical capacitance (EC) and transepidermal water loss (TEWL) in healthy subjects with dry skin and determined efficacy and tolerability in subjects with rosacea. The present study included two independent, open-label investigations: in the first, EC and TEWL were measured at baseline and at two, four, eight, and 24 hours after one application of CRCNC to dry skin; in the second, an evaluation of once-daily CRCNC application for 22 days using a chromameter, image analysis, and trained rater was performed, with patient evaluations at baseline and Days 1, 8, and 22 collected. The first study enrolled 20 subjects (13 women; mean age: 45 years). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334838PMC
December 2018
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