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    [Research progress of intense pulsed light treatment on meibomian gland dysfunction and relevant dry eye diseases].
    Zhonghua Yan Ke Za Zhi 2018 Feb;54(2):140-143
    Department of Ophthalmology, the First Hospital of Peking University, Beijing 100034, China.
    Intense pulsed light (IPL) is a broad spectrum incoherent light which is produced by high-output xenon lamp. Since the invention of the first-generation IPL in 1994, IPL technology has been developing rapidly and extensively utilized in multiple fields relevant to dermatology across the world. In 2004, the fourth-generation IPL system was introduced with the optimal pulse technology (OPT) and has soon been used for cosmetic purposes all over the world. Read More

    Efficacy and Safety of Topical Oxymetazoline Cream 1.0% for Treatment of Persistent Facial Erythema Associated With Rosacea: Findings From the Two Phase 3, 29-Day, Randomized, Controlled REVEAL Trials.
    J Am Acad Dermatol 2018 Jan 30. Epub 2018 Jan 30.
    Allergan plc, Irvine, CA.
    Background: Rosacea is a chronic dermatologic condition with limited treatment options.

    Objective: To evaluate topical oxymetazoline cream 1.0% in patients with moderate to severe persistent erythema of rosacea. Read More

    Efficacy and Safety of Oxymetazoline Cream 1.0% for Treatment of Persistent Facial Erythema Associated With Rosacea: Findings From the 52-Week Open Label REVEAL Trial.
    J Am Acad Dermatol 2018 Jan 30. Epub 2018 Jan 30.
    Allergan plc, Irvine, CA.
    Background: Limited treatments are available for persistent erythema of rosacea.

    Objective: To examine long-term safety and efficacy of oxymetazoline cream 1.0% in rosacea patients with moderate to severe persistent erythema. Read More

    Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases.
    Bioconjug Chem 2018 Feb 6. Epub 2018 Feb 6.
    The overexpression and increased activity of the serine protease Kallikrein 5 (KLK5) is characteristic of inflammatory skin diseases such as Rosacea. The use of inhibitors of this enzyme - such as 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF·HCl) or the anti-human recombinant Kallikrein 5 (anti-KLK5) antibody - in the treatment of the disease has been limited due to their low bioavailability, for which their immobilization in drug delivery agents can contribute to making serine protease inhibitors clinically useful. In this work, we synthesized gold nanoparticles (GNP) coated with a mixture of hydroxyl- and carboxyl terminated thiolates (GNP. Read More

    Picosecond alexandrite laser is superior to Q-switched Nd:YAG laser in treatment of minocycline-induced hyperpigmentation: A case study and review of the literature.
    J Cosmet Laser Ther 2018 Feb 5:1-4. Epub 2018 Feb 5.
    b Hunter New England Local Health District , Department of Dermatology , Royal Newcastle Center , New Lambton , Australia.
    Background: Minocycline is a commonly prescribed tetracycline antibiotic used for the treatment of a number of dermatological conditions including acne and rosacea. Long-term adverse effects of minocycline include cutaneous hyperpigmentation. Various treatment options have been suggested for the treatment of minocycline pigmentation. Read More

    A Phase II, Randomized, Double-Blind Clinical Study Evaluating the Safety, Tolerability, and Efficacy of a Topical Minocycline Foam, FMX103, for the Treatment of Facial Papulopustular Rosacea.
    Am J Clin Dermatol 2018 Feb 2. Epub 2018 Feb 2.
    Foamix Pharmaceuticals, Ltd, 2 Holzman Street, Weizmann-Science Park, 7670402, Rehovot, Israel.
    Objective: Our objective was to demonstrate the safety, tolerability, and efficacy of a minocycline foam, FMX103, in the treatment of moderate-to-severe facial papulopustular rosacea.

    Methods: This was a phase II, randomized, double-blind, multicenter study. Healthy subjects aged ≥ 18 years with moderate-to-severe rosacea that had been diagnosed ≥ 6 months previously and with ≥ 12 inflammatory facial lesions were randomized (1:1:1) to receive once-daily 1. Read More

    To test or not to test: A study examining the return rates of rosacea patients treated with a pulsed dye laser.
    J Cosmet Laser Ther 2018 Feb 1:1-2. Epub 2018 Feb 1.
    a Department of Dermatology , University of Minnesota.
    Pulsed dye laser (PDL) is an effective treatment option for erythematotelangiectatic rosacea. The use of a test spot allows patients to experience the procedure on a small area prior to further treatment. The purpose of this study was to elucidate whether the use of a no charge test spot influenced return rates for further PDL treatment. Read More

    Comparison of efficacy between long-pulsed Nd:YAG laser and pulsed dye laser to treat rosacea-associated nasal telangiectasia.
    J Cosmet Laser Ther 2018 Feb 1:1-5. Epub 2018 Feb 1.
    a Department of Dermatology , Hallym University Sacred Heart Hospital , Anyang , Korea.
    Background: Rosacea is characterized by erythema on face, especially erythema and linear telangiectasia on the nose. Currently, various vascular lasers are used for treatment, and among them, are long-pulsed Nd:YAG(LPNY) and pulsed dye laser (PDL).

    Objectives: This study compared the efficacy of LPNY and PDL in treating rosacea-associated nasal telangiectasia. Read More

    In Vitro Safety Pharmacology Profiling of Topical α-Adrenergic Agonist Treatments for Erythema of Rosacea.
    Drugs R D 2018 Jan 27. Epub 2018 Jan 27.
    Department of Physiology, Royal College of Surgeons in Ireland, Dublin, Ireland.
    Background: Topical α-adrenergic agonist therapy has been developed to treat the persistent erythema of rosacea patients. Brimonidine and oxymetazoline are both topical α-adrenergic agonists.

    Objectives: The objective of this in vitro safety pharmacology study was to compare the potential safety profiles of brimonidine and oxymetazoline. Read More

    Morbihan disease: a therapeutic challenge.
    An Bras Dermatol 2017 Nov-Dec;92(6):847-850
    Dermatology Service at Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro (HUPE-UERJ) - Rio de Janeiro (RJ), Brazil.
    Morbihan disease is a rare condition characterized by chronic and persistent erythematous solid edema localized on the face. It is believed to be a complication of rosacea and may occur at any stage of the disease. Features of this condition include variable therapeutic response and great refractoriness. Read More

    Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study.
    An Bras Dermatol 2017 Nov-Dec;92(6):820-825
    Department of Cardiology, Mugla Sitki Kocman University Medical School - Muğla, Turkey.
    Background: Rosacea is a chronic facial skin disease associated with excessive inflammatory response to various triggers. Although some studies have supported the increased risk of cardiovascular diseases in rosacea, it has not been completely accepted.

    Objective: We aimed to investigate epicardial fat thickness and carotid intima-media thickness as cardiovascular risk predictors in rosacea patients. Read More

    Pediatric periorificial dermatitis.
    Cutis 2017 Dec;100(6):385-388
    Department of Dermatology, Mt Sinai West of the Icahn School of Medicine, New York, New York, USA.
    Periorificial dermatitis (POD) has been documented in the pediatric population in patients as young as 3 months, with a slight predominance in girls compared to boys. Many patients have a personal or family history of atopic disorders. Periorificial dermatitis typically presents with erythematous to flesh-colored papules and rarely pustules near the eyes, nose, and mouth. Read More

    Approach to treatment of medical and cosmetic facial concerns in skin of color patients.
    Cutis 2017 Dec;100(6):375-380
    Department of Dermatology, University of Pennsylvania, Philadelphia, USA.
    Facial concerns in skin of color (SOC) patients vary and can be a source of emotional and psychological distress. This article discusses 4 common facial concerns in SOC patients: acne, rosacea, facial hyperpigmentation, and cosmetic enhancement. Treatment recommendations are provided as well as management pearls. Read More

    Social factors and aromatase gene expression during adult male-to-female sex change in captive leopard grouper Mycteroperca rosacea.
    Gen Comp Endocrinol 2018 Jan 25. Epub 2018 Jan 25.
    Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Calle IPN 195, La Paz, B.C.S. 23096, Mexico. Electronic address:
    Social factors and aromatase gene expression in the leopard grouper Mycteroperca rosacea was studied when captive fish were separated by sex during the reproductive (April-June) and post-reproductive (July-September) seasons. Monosex females, monosex males, and mixed-sex, held in social sextet units were analyzed for sex steroids throughout confinement. At the end of the experiment, the gonad-sex was defined by histology, and gonad and brain aromatase gene expressions were quantified. Read More

    Skin and Diet: An Update on the Role of Dietary Change as a Treatment Strategy for Skin Disease.
    Skin Therapy Lett 2018 01;23(1):1-5
    Georgetown University School of Medicine, Washington, DC, USA.
    An increasing body of research indicates that dietary change may serve as a component of therapy for certain skin conditions. This includes conditions such as acne, atopic dermatitis, aging skin, psoriasis, and rosacea. Certain nutrients, foods, or dietary patterns may act as disease "triggers", while others may prove beneficial. Read More

    Inate immunity in rosacea. Langerhans cells, plasmacytoid dentritic cells, Toll-like receptors and inducible oxide nitric synthase (iNOS) expression in skin specimens: case-control study.
    Arch Dermatol Res 2018 Mar 12;310(2):139-146. Epub 2018 Jan 12.
    Department of Dermatology, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, sala 3021, 05403-000, São Paulo, Brazil.
    Rosacea is a chronic inflammatory condition with predominant facial involvement. Because of that, many patients sense that rosacea affects quality of life. The etiology of rosacea remains unknown. Read More

    Pivotal Trial of the Efficacy and Safety of Oxymetazoline Cream 1.0% for the Treatment of Persistent Facial Erythema Associated With Rosacea: Findings from the First REVEAL Trial.
    J Drugs Dermatol 2018 Jan;17(1):97-105
    An unmet need exists for a safe, tolerable, effective treatment for moderate to severe persistent facial erythema in patients with rosacea. This pivotal phase 3, multicenter, double-blind study evaluated the efficacy and safety of topical oxymetazoline in patients with facial erythema associated with moderate to severe rosacea. Patients were randomly assigned to treatment with oxymetazoline hydrochloride cream 1. Read More

    Patients' self-esteem before and after chemical peeling procedure.
    J Cosmet Laser Ther 2017 Dec 29:1-3. Epub 2017 Dec 29.
    a Department of Dermatology and Venereology , Andreas Sygros Hospital , Athens , Greece.
    Introduction: Chemical peeling is a safe method, widely used to treat a variety of skin conditions and reduce the aging effects. This study aims to evaluate self-esteem among adolescents who undergo chemical peelings.

    Material And Methods: One hundred and twenty six patients constituted the study group. Read More

    Characterization of the facial microbiome in twins discordant for rosacea.
    Exp Dermatol 2017 Dec 28. Epub 2017 Dec 28.
    Department of Dermatology Cleveland, OH, US.
    Previously, we determined that genetic and environmental factors contributed equally towards rosacea in twins. To assess an environmental factor, we characterized the malar cheek bacterial microbiome from twins discordant for rosacea. We found no significant difference in facial microbiome alpha and beta diversity between related twins discordant for rosacea. Read More

    Demodex and rosacea: Is there a relationship?
    Indian J Ophthalmol 2018 Jan;66(1):36-38
    Department of Ophthalmology, Hospital General Gea Gonzalez, Calzada de Tlalpan 4800, México.
    Purpose: The objective of the study is to compare the frequency of Demodex on the eyelash follicle of patients with rosacea and referents without rosacea or ophthalmological disorders.

    Methods: This is a comparative, open, observational, and cross-sectional study that included 41 patients diagnosed with rosacea and 41 referents without rosacea diagnosis or ophthalmic alterations. The individuals underwent a slit-lamp examination in which two eyelashes per eyelid were removed with fine forceps. Read More

    An unusual presentation of ocular rosacea.
    Arq Bras Oftalmol 2017 Nov-Dec;80(6):396-398
    Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.
    Rosacea is a chronic, progressive disease of unknown cause affecting the eye and the facial skin. Ocular rosacea is often underdiagnosed if the ophthalmologist does not inspect the patient's face adequately during the ocular examination. Severe ocular complications and blindness can occur if the treatment is delayed because of non-diagnosis of the rosacea. Read More

    Combination of platelet rich plasma in fractional carbon dioxide laser treatment increased clinical efficacy of for acne scar by enhancement of collagen production and modulation of laser-induced inflammation.
    Lasers Surg Med 2017 Dec 20. Epub 2017 Dec 20.
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
    Background: Platelet-rich plasma (PRP) which contains large amounts of growth factors has been tried to enhance therapeutic efficacy of laser treatment for acne scar with unknown underlying mechanism.

    Objectives: The present study was conducted to investigate the molecular mechanism of increased clinical efficacy of PRP when combined with fractional laser treatment for treating acne scars.

    Methods: Subjects with mild to moderate acne scars were treated with two sessions of fractional COlaser therapy given with and without co-administration of PRP. Read More

    Long-pulsed 1064-nm Nd: YAG laser ameliorates LL-37-induced rosacea-like skin lesions through promoting collagen remodeling in BALB/c mice.
    Lasers Med Sci 2018 Feb 18;33(2):393-397. Epub 2017 Dec 18.
    Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul, 150713, South Korea.
    Long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser (LPND) effectively treats rosacea, although the underlying mechanism is unclear, to evaluate the histological effects and molecular mechanism of LPND on LL-37-induced rosacea-like skin lesions in mice. Intradermal injection of LL-37 was performed into the dorsal skin of BALB/c mice (n = 30) twice a day for 2 days. Fifteen mice were treated with LPND. Read More

    [What's new in pediatric dermatology?]
    Ann Dermatol Venereol 2017 Dec;144 Suppl 4:IVS29-IVS39
    Centre de référence des maladies rares de la peau et des muqueuses d'origine génétique, service de dermatologie, hôpital Archet 2, CHU de Nice, France. Electronic address:
    The year 2017 in pediatric dermatology was marked by several consensus recommendations and meta analyzes on childhood psoriasis, atopic dermatitis or PHACE syndrome, case series on the role of anti-JAK treatment in adolescent with alopecia areata, sirolimus for vascular malformations, ivermectine for rosacea, inhibitors of MEK for type 1 neurofibromatosis or on the side effects of the oral isotretinoin for acne or propranolol for immature hemangioma. Only few randomized controlled studies have been published on the interest of adalimumab in the treatment of psoriasis or topical sirolimus for angiofibroma in tuberous sclerosis complex for example. There were also clinical articles on various affections such as the sign of the scalp hair collar sign, childhood prurigo, ichthyosis, atopic dermatitis, warts or Zika virus infection. Read More

    Reply to: "Rosacea and alcohol intake".
    J Am Acad Dermatol 2018 Jan;78(1):e27
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

    Miscellaneous skin disease and the metabolic syndrome.
    Clin Dermatol 2018 Jan - Feb;36(1):94-100. Epub 2017 Sep 8.
    Department of Dermatology, Istanbul Medeniyet University, Medical School, Istanbul, Turkey. Electronic address:
    The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS. Read More

    Pityriasis Folliculorum: Response to Topical Ivermectin
    J Drugs Dermatol 2017 12;16(12):1290-1292
    Pityriasis folliculorum has been described as a dry type of rosacea with extensive proliferation of Demodex folliculorum in pilosebaceous follicles of the skin. This skin condition is frequently difficult to manage, with various treatment options showing mixed efficacy. Oral ivermectin, a macrocyclic lactone parasiticide with anti-inflammatory and anti-parasitic effects, is one of the leading treatment modalities for demodicosis. Read More

    The Latest Drugs and Small Molecule Inhibitors for Skin and Hair.
    J Drugs Dermatol 2017 12;16(12):1224-1228
    Biologic drugs, a novel class of agents engineered to target specific mediators of inflammation, and small-molecule inhibitors that penetrate the cell membrane to interact with targets inside a cell represent the cutting-edge of pharmacological biomedical therapeutics. Clinical studies have already demonstrated the effectiveness of this new generation of drugs in treating a variety of medical illnesses and conditions that were refractory to traditional treatments. This review aims to describe the latest available or currently in-development drugs, biologic agents, and small molecule inhibitors for treatment of psoriasis, rosacea, alopecia areata, and atopic dermatitis. Read More

    State-of-the-art lasers and light treatments for vascular lesions: from red faces to vascular malformations.
    Semin Cutan Med Surg 2017 Dec;36(4):207-212
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, California, USA.
    Notable milestones in the treatment of vascular lesions have been achieved over the past century. Many cutaneous vascular lesions can be successfully treated with lightbased devices. In this review, we will discuss the treatment of port-wine birthmarks, lymphatic malformations, infantile hemangiomas, rosacea, venous lakes, pyogenic granulomas, cherry angiomas, and angiofibromas using lasers, total reflection amplification of spontaneous emission of radiation, intense pulsed light, and photodynamic therapy. Read More

    Idiopathic Facial Aseptic Granuloma: Clinical and Ultrasound Findings in 3 Cases.
    Actas Dermosifiliogr 2017 Dec 4. Epub 2017 Dec 4.
    Servicio de Dermatología, Hospital Universitario La Paz, Madrid, España.
    Idiopathic facial aseptic granuloma is a typical childhood disease characterized by the presence of one or more asymptomatic nodules on the cheek. Although pathogenesis remains unclear, the disease is thought to be a type of childhood rosacea. It resolves spontaneously, yet it could be confused with other lesions that require treatment. Read More

    Diet and rosacea: the role of dietary change in the management of rosacea.
    Dermatol Pract Concept 2017 Oct 31;7(4):31-37. Epub 2017 Oct 31.
    Baylor College of Medicine, Houston, TX, USA.
    Dietary change may play a role in the therapy of rosacea. Certain foods and beverages may act as "triggers" for rosacea exacerbations. These may be divided into heat-related, alcohol-related, capsaicin-related, and cinnamaldehyde-related. Read More

    Endosymbiosis and its significance in dermatology.
    J Eur Acad Dermatol Venereol 2017 Dec 1. Epub 2017 Dec 1.
    Department of Medical Biology, Faculty of Health Sciences, Warmia and Mazury University, Olsztyn, Poland.
    Proposed at the beginning of the twentieth century to explain the origin of eukaryotic organelles from prokaryotes, endosymbiosis is now medically defined by various interaction patterns between microorganisms and their residing hosts, best exemplified by the bacterial endosymbiont Wolbachia identified in arthropods and filarial nematodes, which can influence normal development, reproduction, survival and transmission of the hosts. Based on the transmission modes, vertical or horizontal, and the function of the endosymbionts, the host-symbiont dependence can be divided into primary or secondary. In dermatology, the role of endosymbionts in skin ectoparasitosis has aroused great interests in the past years. Read More

    Human Skin Permeation Studies with PPARγ Agonist to Improve Its Permeability and Efficacy in Inflammatory Processes.
    Int J Mol Sci 2017 Nov 28;18(12). Epub 2017 Nov 28.
    Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
    Rosacea is the most common inflammatory skin disease. It is characterized by erythema, inflammatory papules and pustules, visible blood vessels, and telangiectasia. The current treatment has limitations and unsatisfactory results. Read More

    A case of paracoccidioidomycosis due topresenting sarcoid-like form.
    Med Mycol Case Rep 2018 Mar 25;19:6-8. Epub 2017 Sep 25.
    Division of Infectious Diseases, Universidade Federal do Espírito Santo, Vitória 29043-900, Espírito Santo, Brazil.
    Paracoccidioidomycosis (PCM) is a fungal disease caused by Paracoccidioides spp., which can cause a systemic granulomatous infection with tegumentary and visceral involvement. Sarcoid-like skin lesions are uncommon and can be misdiagnosed due to similarities witherythematous infiltrated plaques on her face that was treated for leprosy and rosacea with no response and was later diagnosed with PCM, presenting positive serology for Paracoccidioides lutzii. Read More

    Ocular Rosacea Causing Corneal Melt in an African American Patient and a Hispanic Patient.
    Case Rep Ophthalmol Med 2017 11;2017:2834031. Epub 2017 Oct 11.
    University of Texas Southwestern Medical Center, Ophthalmology Department, Dallas, TX, USA.
    Purpose: To discuss two rare presentations of ocular rosacea in a Hispanic patient and an African American patient with unusual ocular manifestations.

    Case Report: Case  1: a 43-year-old Hispanic woman presented with right eye corneal perforation. Her prior medical history was significant for rosacea only, diagnosed clinically by a dermatologist. Read More

    Comorbidities in rosacea: A systematic review and update.
    J Am Acad Dermatol 2017 Oct 26. Epub 2017 Oct 26.
    Department of Internal Medicine, Hotel Dieu de France University Hospital, Beirut, Lebanon; Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
    Background: Rosacea is linked to abnormalities of cutaneous vasculature and dysregulation of the inflammatory response. Recent reports on rosacea have shown a significant association with cardiovascular, gastrointestinal, and psychiatric diseases, all of which may affect morbidity and mortality among these patients.

    Objective: To review available data regarding comorbidities associated with rosacea, discuss their pathogenesis, and highlight the evaluation of affected patients. Read More

    Topical a-Agonist Therapy for Persistent Facial Erythema of Rosacea and the Addition of Oxmetazoline to the Treatment Armamentarium: Where Are We Now?
    J Clin Aesthet Dermatol 2017 Jul 1;10(7):28-32. Epub 2017 Jul 1.
    Dr. Del Rosso is Research Director at JDR Dermatology Research, Las Vegas, Nevada and at Henderson Dermatology Research in Henderson, Nevada; is Adjunct Clinical Professor (Dermatology) at Touro University Nevada, Las Vegas, Nevada; and practices Dermatology and Cutaneous Surgery at Thomas Dermatology in Las Vegas, Nevada.
    The presence of vasoactivity in rosacea-affected skin led to the development of two topical α-adrenergic receptor agonists, brimonidine tartrate 0.5% gel and oxymetazoline hydrochloride 1% cream, both approved by the United States Food and Drug Administration for treatment of persistent facial erythema of rosacea. In this article, the author discusses challenges related to the treatment of persistent facial erythema of rosacea and the use of a-agonist therapy. Read More

    Role of Topical Oxymetazoline for Management of Erythematotelangiectatic Rosacea.
    Ann Pharmacother 2018 Mar 2;52(3):263-267. Epub 2017 Nov 2.
    1 Idaho State University, Pocatello, ID, USA.
    Objective: To review and summarize topical oxymetazoline's pharmacology, pharmacokinetics, efficacy, safety, cost, and place in therapy for persistent redness associated with erythematotelangiectatic rosacea.

    Data Sources: Literature searches of MEDLINE (1975 to September 2017), International Pharmaceutical Abstracts (1975 to September 2017), and Cochrane Database (publications through September 2017) using the terms rosacea, persistent redness, α -agonist, and oxymetazoline.

    Study Selection And Data Extraction: Results were limited to studies of human subjects, English-language publications, and topical use of oxymetazoline. Read More

    Real-World Efficacy of Azelaic Acid 15% Gel for the Reduction of Inflammatory Lesions of Rosacea.
    Skin Therapy Lett 2017 11;22(6):5-7
    Department of Dermatology, Weill Medical College of Cornell University, New York, NY, USA.
    Approximately 16 million Americans have rosacea, an inflammatory cutaneous disorder with central facial erythema, papules, pustules, telangiectasia, flushing, and swelling being among the more commonly recognized features. Overexpression of cathelicidin peptide LL-37 has been implicated in the pathophysiology of rosacea. Azelaic acid has been found to inhibit the pathologic expression of cathelicidin, as well as the hyperactive protease activity that cleaves cathelicidin into LL-37. Read More

    Severe Rosacea: A Case Report.
    J Ophthalmic Vis Res 2017 Oct-Dec;12(4):429-433
    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Purpose: To describe a case of severe rosacea with ocular involvement.

    Case Report: A 28-year-old female patient presented with extensive facial and ocular eruptions. She had a history of treatment with oral prednisolone due to the clinical diagnosis of lupus erythematosus (LE), which had resulted in transient improvement of the lesions, but was followed by exacerbation of the lesions. Read More

    Evidence-based update on rosacea comorbidities and their common physiologic pathways.
    J Am Acad Dermatol 2018 Jan 28;78(1):156-166. Epub 2017 Oct 28.
    Department of Dermatology, Stanford University School of Medicine, Redwood City, California. Electronic address:
    Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology and pathophysiology are the subject of much investigation. Risk factors include genetic and environmental elements that may predispose individuals to localized inflammation and abnormal neurovascular responses to stimuli. Recent studies have introduced an array of systemic rosacea comorbidities, such as inflammatory bowel disease and neurologic conditions, that can be challenging to synthesize. Read More

    Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee.
    J Am Acad Dermatol 2018 Jan 28;78(1):148-155. Epub 2017 Oct 28.
    Department of Dermatology, Pennsylvania State University, Hershey, Pennsylvania.
    In 2002, the National Rosacea Society assembled an expert committee to develop the first standard classification of rosacea. This original classification was intended to be updated as scientific knowledge and clinical experience increased. Over the last 15 years, significant new insights into rosacea's pathogenesis and pathophysiology have emerged, and the disorder is now widely addressed in clinical practice. Read More

    Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources.
    Molecules 2017 Oct 27;22(11). Epub 2017 Oct 27.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan.
    Stratum corneum tryptic enzyme kallikrein 5 (KLK5) is a serine protease that is involved in the cell renewal and maintenance of the skin barrier function. The excessive activation of KLK5 causes an exacerbation of dermatoses, such as rosacea and atopic dermatitis. Some triterpenoids are reported to suppress the serine proteases. Read More

    Development of Ocular Rosacea following Combined Ipilimumab and Nivolumab Treatment for Metastatic Malignant Skin Melanoma.
    Ocul Oncol Pathol 2017 Sep 2;3(3):188-192. Epub 2017 Feb 2.
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
    Purpose: To report a case of severe ocular rosacea following ipilimumab plus nivolumab treatment in a patient with metastatic malignant skin melanoma.

    Methods: Case report and review of the literature.

    Results: A 68-year-old male with newly diagnosed metastatic malignant cutaneous melanoma was treated with first-line ipilimumab plus nivolumab, which resulted in a partial response. Read More

    Uncaria tomentosa.
    G Ital Dermatol Venereol 2017 Dec;152(6):651-657
    Unit of Dermatology, Department of Medical-Surgical Physiopathology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy -
    Uncaria tomentosa (U. tomentosa) or uña de gato, a species of vine of Rubiaceae family, was used from centuries in various medical conditions. Although there are no randomized controlled trials or published human outcome studies, some conditions reportedly improved by U. Read More

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