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    1 OF 69

    [Rosacea: New data for better care].
    Ann Dermatol Venereol 2017 Jul 17. Epub 2017 Jul 17.
    Clinique dermatologique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address:
    In the last 10 years, numerous studies have been published that throw new light on rosacea, in all areas of the disease. This overview summarises all the key developments, based on the indexed bibliography appearing in Medline between 2007 and 2017. Recent epidemiological data show that the prevalence of the disease is doubtless greater than estimated hitherto (more than 10% of adults in some countries) and that we should not overlook rosacea in subjects with skin phototypes V or VI, a condition that exists on all continents. Read More

    Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis.
    J Am Acad Dermatol 2017 Jul 12. Epub 2017 Jul 12.
    Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Background: The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely.

    Objective: We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea.

    Methods: Systematic literature review and meta-analysis were conducted. Read More

    Light-based devices in the treatment of cutaneous vascular lesions: An updated review.
    J Cosmet Dermatol 2017 Jul 13. Epub 2017 Jul 13.
    Skin Laser & Surgery Specialists of New York and New Jersey, New York, NY, USA.
    Background: Light-based devices have been used to treat cutaneous vascular lesions almost since the original development of the laser. After the introduction of the initial continuous wave and pulsed laser systems, the pulsed lasers became the gold standard device. Since then, new devices and methods to treat patients have been introduced. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 07 13;31(2 Suppl. 2). Epub 2017 Jul 13.
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    An observational descriptive survey of rosacea in the Chinese population: clinical features based on the affected locations.
    PeerJ 2017 7;5:e3527. Epub 2017 Jul 7.
    Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
    Background: There is currently no study that has evaluated the differences in epidemiological and clinical characteristics among rosacea patients according to different facial sites.

    Methods: Clinical and demographic data were obtained from 586 rosacea patients. The patients were divided into four groups based on the main sites involved with the rosacea lesions (full-face, cheeks, nose, or perioral involvement). Read More

    Pediatric blepharokeratoconjunctivitis: is there a 'right' treatment?
    Curr Opin Ophthalmol 2017 Jul 10. Epub 2017 Jul 10.
    aDivision of Pediatric Ophthalmology, Robert Wood Johnson Medical School, New Brunswick, New Jersey bWills Eye Hospital, Philadelphia, Pennsylvania, USA.
    Purpose Of Review: This article highlights the importance of recognizing blepharokeratoconjunctivitis (BKC) in children and reviews the clinical characteristics and current therapeutic modalities.

    Recent Findings: The mainstay of BKC treatment remains controlling the meibomian gland inflammation and treating cobormid conditions. BKC can occur in the setting of ocular rosacea and Demodex infestation. Read More

    Efficacy and Tolerability of a Cosmetic Skin Care Product With Trans-4-t-butylcyclohexanol and Licochalcone A in Subjects With Sensitive Skin Prone to Redness and Rosacea.
    J Drugs Dermatol 2017 Jun;16(6):605-610

    BACKGROUND: Sensitive skin and rosacea are skin conditions, which may affect the quality of life of the patients considerably. In vitro and in vivo data indicated that the combination of trans-t-butylcyclohexanol and licochalcone A is an effective combination for alleviating the increased sensitivity of rosacea subtype I.

    OBJECTIVE: Objective of this open dermocosmetic study was to investigate the efficacy and tolerability of a skin care product containing the anti-inflammatory licochalcone A and the TRPV1 antagonist trans-t-butylcyclohexanol in subjects with sensitive skin prone to redness and rosacea. Read More


    A Pilot, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of IncobotulinumtoxinA Injections in the Treatment of Rosacea.
    J Drugs Dermatol 2017 Jun;16(6):549-554

    BACKGROUND: Rosacea has a variable presentation. Whereas the pathophysiology may differ, erythema, and flushing are the most consistent findings in all patients.

    OBJECTIVE: To evaluate the safety and efficacy of incobotulinumtoxinA in reducing the severity of rosacea symptoms. Read More


    Experiences of rosacea and its treatment: An interpretative phenomenological analysis.
    Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.
    The University of Sheffield, Western Bank, Sheffield, S10 2TP.
    Background: Whilst rosacea is a chronic skin condition, the condition can often have a large psychosocial impact on the individual. There is therefore a need to understand the experience of living with rosacea from the patient perspective.

    Objectives: To examine the experience of living with rosacea and the experience of seeking and receiving treatment. Read More

    Bilateral Morganella Morganii keratitis in a patient with facial topical corticosteroid-induced rosacea-like dermatitis: a case report.
    BMC Ophthalmol 2017 Jun 28;17(1):106. Epub 2017 Jun 28.
    Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, People's Republic of China.
    Background: Bilateral keratitis rarely occurs in individuals without predisposing factors. Here we describe the clinical course of a patient who developed a bilateral keratitis caused by Morganella. morganii which might be associated with long term using of topical corticosteroids-containing preparations on the face. Read More

    Diagnosis and Treatment of Rosacea Fulminans: A Comprehensive Review.
    Am J Clin Dermatol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Dermatology, University of California San Francisco, 1701 Divisadero Street, 3rd Floor, San Francisco, CA, 94115, USA.
    Rosacea fulminans is a rare inflammatory condition of the central face marked by the abrupt onset of erythematous coalescing papules, pustules, nodules, and draining sinuses. Due to infrequent reporting in the literature, the pathophysiology, classification, and nomenclature of this condition remain controversial. This comprehensive review evaluated a total of 135 cases of rosacea fulminans for clinical and histopathologic features and reported treatment strategies. Read More

    Dual anti-inflammatory and antiparasitic action of topical ivermectin 1% in papulopustular rosacea.
    J Eur Acad Dermatol Venereol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Dermatology, Eberhard Karls University Tuebingen.
    Background: Recently, therapy of rosacea with inflammatory lesions (papulopustular) has improved substantially with the approval of topical ivermectin 1% cream. It is assumed to have a dual mode of action with anti-inflammatory capacities and anti-parasitic effect against Demodex, which however has not yet been demonstrated in vivo.

    Aim: To find scientific rationale for the dual anti-inflammatory and anti-parasitic mode of action of topical ivermectin 1% cream in patients with rosacea. Read More

    Evaluation of a novel very high sun-protection-factor moisturizer in adults with rosacea-prone sensitive skin.
    Clin Cosmet Investig Dermatol 2017 10;10:211-219. Epub 2017 Jun 10.
    Galderma Research and Development, Egerkingen, Switzerland.
    Background/objective: Rosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners.

    Subjects And Methods: This was an open-label, single-center study. Read More

    Prescription patterns and costs of acne/rosacea medications in Medicare patients vary by prescriber specialty.
    J Am Acad Dermatol 2017 Jun 23. Epub 2017 Jun 23.
    Department of Internal Medicine, Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:
    Background: Prescription patterns for acne/rosacea medications have not been described in the Medicare population, and comparisons across specialties are lacking.

    Objective: To describe the medications used for treating acne/rosacea in the Medicare population and evaluate differences in costs between specialties.

    Methods: A cross-sectional study was performed of the 2008 and 2010 Centers for Medicare and Medicaid Services Prescription Drug Profiles, which contains 100% of Medicare part D claims. Read More

    The Role of Polyphenols in Rosacea Treatment: A Systematic Review.
    J Altern Complement Med 2017 Jun 26. Epub 2017 Jun 26.
    4 Department of Dermatology and Cutaneous Surgery, University of Miami , Miami, FL.
    Objectives: Various treatment options are available for the management of rosacea symptoms such as facial erythema, telangiectasia, papules and pustules, burning, stinging, and itching. Botanical therapies are commonly used to treat the symptoms. The objective of this review is to evaluate the use of polyphenols in rosacea treatment. Read More

    Rosacea in black South Africans with skin phototypes V and VI.
    Clin Exp Dermatol 2017 Aug 22;42(6):670-673. Epub 2017 Jun 22.
    Dermatology Department, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Rosacea is a chronic facial dermatosis considered to affect primarily white patients with light phototype skin, and is poorly documented in black patients. The aim of this study was to document the clinical features of rosacea in patients with phototypes V and VI. An 8-year retrospective chart review of patients with a clinical and histological diagnosis of rosacea or acne rosacea was undertaken. Read More

    Rosacea and its association with enteral microbiota in Korean females.
    Exp Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine.
    Background: Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain.

    Objectives: We aimed to investigate the link between rosacea and enteral microbiota. Read More

    Rate of Adverse Events and Healthcare Costs Associated with the Topical Treatment of Rosacea.
    Am Health Drug Benefits 2017 May;10(3):113-119
    Deputy Director, US Data Generation & Observational Studies Data Analytics, Bayer HealthCare Pharmaceuticals.
    Background: Rosacea is a condition more common in women than in men, and in people aged ≥30 years than in younger patients. Adverse events associated with the use of topical medications for rosacea may lead to a lack of treatment adherence. Previous studies have reported low treatment adherence rates among patients with rosacea. Read More

    Systemic therapy of ocular and cutaneous rosacea in children.
    J Eur Acad Dermatol Venereol 2017 Jun 16. Epub 2017 Jun 16.
    University Hospital of Tuebingen, Department of Dermatology.
    Background: In paediatric rosacea, ocular symptoms are often predominant. Literature about systemic therapy of paediatric ocular rosacea is sparse, though.

    Objective: Analysis of children with ocular rosacea treated systemically, particularly addressing remission and recurrence rates. Read More

    Defining treatment success in rosacea as 'clear' may provide multiple patient benefits: results of a pooled analysis.
    J Dermatolog Treat 2017 Aug 4;28(5):469-474. Epub 2017 Jul 4.
    f Galderma International , Paris , France.
    Background: Rosacea treatment success is usually defined as a score of 1 ('almost clear') or 0 ('clear') on the 5-point Investigator Global Assessment (IGA) scale.

    Objective: To evaluate whether, after successful treatment, 'clear' subjects had better outcomes than 'almost clear' subjects.

    Methods: A pooled analysis was performed on 1366 rosacea subjects from four randomized controlled trials with IGA before and after treatment (ivermectin, metronidazole or vehicle). Read More

    A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients.
    Mayo Clin Proc 2017 Jul 7;92(7):1053-1060. Epub 2017 Jun 7.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
    Objective: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach.

    Patients And Methods: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011.

    Results: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial. Read More

    Erratum.
    • Authors:
    J Cutan Med Surg 2017 Jun 1:1203475417715265. Epub 2017 Jun 1.
    Yuka A, Tan J, Baibergenova A, Barankin B, Cochrane CL, Humphrey S, Lynde CW, Marcoux D, Poulin Y, Rivers JK, Sapijaszko M, Sibbald RG, Toole J, Ulmer M, Zip C. Canadian Clinical Practice Guidelines for Rosacea. J Cutan Med Surg. Read More

    [Facial manifestations of granulomatous diseases].
    Hautarzt 2017 Jul;68(7):542-547
    Hautklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz KöR, Langenbeckstr. 1, 55131, Mainz, Deutschland.
    Clinical manifestations of granulomatous diseases are a recurring challenge in everyday dermatological practice. Clinical presentation and histological patterns are variable, depending on the particular disease. Knowledge about the differential diagnosis of granulomatous changes in the face is of decisive importance for making a rational diagnosis and therapy considering the patient's well-being. Read More

    Misuse of Topical Corticosteroids over Face: A Clinical Study.
    Indian Dermatol Online J 2017 May-Jun;8(3):186-191
    Department of Dermatology, Swami Dayanand Hospital, New Delhi, India.
    Introduction: Topical corticosteroids (TCS) have been widely used in various dermatological diseases. However, because of inadvertent use, TCS misuse has become a common problem faced by dermatologists in various parts of the world. Prolonged use over the face can cause various side effects such as steroid rosacea, acneiform eruptions, and hypertrichosis. Read More

    Rosacea is associated with Helicobacter pylori: a systematic review and meta-analysis.
    J Eur Acad Dermatol Venereol 2017 May 23. Epub 2017 May 23.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Background: Rosacea is a common skin disease characterized by facial erythema, telangiectasia, papules and pustules. Helicobacter pylori infection has been suggested to play a role in the etiopathogenesis of rosacea.

    Objective: To systematically review and meta-analyse the relationship between rosacea and infection with Helicobacter pylori. Read More

    Erythromelalgia involving the face.
    Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.
    Baylor College of Medicine, Houston, Texas.
    Erythromelalgia is a rare disorder characterized by burning pain, erythema, and increased temperature typically involving the distal extremities. Although it can progress to involve the face, erythromelalgia presenting only on the face is particularly rare. This disorder is often misdiagnosed when it presents on the extremities and is even more likely to be misdiagnosed when presenting only on the face, delaying appropriate treatment and causing considerable frustration for the patient. Read More

    Surgical treatment of rhinophyma: experience from a German cohort of 70 patients.
    Eur J Dermatol 2017 Jun;27(3):281-285
    Department of Dermatology, University Medical Center, Eberhard Karls University, Tübingen, Germany.
    Rhinophyma is a deforming soft tissue hyperplasia of the nose and surgical removal represents the treatment of choice. Comprehensive data on surgical therapy and the impact of rhinophyma on patient quality of life are lacking. Patients who received surgery for rhinophyma between 2006 and 2015 were retrospectively evaluated for postoperative complications, clinical outcome, recurrence of rhinophyma, and the impact of rhinophyma on daily life. Read More

    Cutaneous adverse effects during ipilimumab treatment for metastatic melanoma: a prospective study.
    Eur J Dermatol 2017 Jun;27(3):266-270
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. Read More

    The Role of Skin Care in Optimizing Treatment of Acne and Rosacea.
    Skin Therapy Lett 2017 May;22(3):5-7
    Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada.
    A triad approach to the treatment of acne and rosacea has been recommended. This integrated management approach includes patient education, selection of therapeutic agents, and initiation of an appropriate skin care regime. Proper skin care in patients undergoing treatment of both acne and rosacea includes use of products formulated for sensitive skin that cleanse, moisturize and photoprotect the skin. Read More

    Mucocutaneous Hyperpigmentation in a Patient With a History of Both Minocycline and Silver Ingestion.
    Am J Dermatopathol 2017 Apr 27. Epub 2017 Apr 27.
    *Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain;†Group of Translational Investigation in Cellular Communication and Signaling (CellCOM-SB), Biomedical Investigation Institute of A Coruña (INIBIC), A Coruña, Spain;‡Department of Cellular Pathology, Hospital de la Reina, Ponferrada, Spain;§Private Practice, Laser Skin Care Center, Dermatology Private Practice, Long Beach, CA; and¶Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA.
    Minocycline is a derivative of tetracycline. It has been widely used in dermatology for the treatment of acne and rosacea. One of its adverse effects is pigmentation of various body tissues. Read More

    Rosacea.
    Aust Fam Physician 2017 ;46(5):277-281
    Background: Rosacea is a chronic and common cutaneous condition characterised by symptoms of facial flushing and a broad spectrum of clinical signs. The clinical presentation for rosacea is varied, and there are four primary subtypes, which may overlap - erythrotelangiectatic, inflammatory, phymatous and ocular. It is important to recognise the different subtypes because of the differences in therapy. Read More

    Cigarette smoking and risk of incident rosacea in women.
    Am J Epidemiol 2017 May 3. Epub 2017 May 3.
    The relationship between smoking and rosacea is poorly understood; we aimed to conduct the first cohort study to determine the association between smoking and risk of incident rosacea. We included 95,809 women from Nurses' Health Study II (1991-2005). Information on smoking was collected biennially during follow-up. Read More

    Effects of Helicobacter pylori treatment on rosacea: A single-arm clinical trial study.
    J Dermatol 2017 Apr 28. Epub 2017 Apr 28.
    Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Rosacea is a chronic dermatological disease. Helicobacter pylori has been discussed as one of its causative factors. In this clinical trial study, we attempted to evaluate the effect of H. Read More

    Lupus miliaris disseminatus faciei: A resistant case with response to cyclosporine.
    Dermatol Ther 2017 Apr 26. Epub 2017 Apr 26.
    Lok Nayak Hospital, Address, 107 Cruikshank Street, Frenchville, Rockhampton, QLD 4701, Australia.
    Lupus miliaris disseminatus faciei (LMDF) is a chronic, inflammatory dermatosis of unknown etiology, characterized by multiple, monomorphic, symmetrical, reddish-brown papules over forehead, cheeks, and eyelids. Histopathology shows perifollicular epitheloid cell granuloma. Though numerous therapies, ranging from cyclines, macrolides, dapsone tranilast, isotretinoin, steroids, and tacrolimus have been tried, the results are inconsistent, except with systemic steroids. Read More

    Protective Effect of Botulinum Toxin Type A Against Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.
    Dermatol Surg 2017 Apr 24. Epub 2017 Apr 24.
    *Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; †Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; ‡Institute of Dermatological Science, Seoul National University, Seoul, Korea; §Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Background: Botulinum neurotoxin (BTX) A possesses various biological activities, including anti-inflammatory and antipruritic actions. Human and animal studies have shown that BTX is effective in treating histamine-induced itch, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar prevention. However, its effect on atopic dermatitis (AD) has not been studied yet. Read More

    Disseminated extrafacial rosacea with papulonecrotic lesions.
    J Dermatol Case Rep 2016 Dec 31;10(4):68-72. Epub 2016 Dec 31.
    Department of Dermatology, Jichi Medical University Saitama Medical Center, Japan.
    Background: Rosacea is a common skin disease and predominantly affects on the face of middle-aged women. It exceptionally occurs on the extrafacial areas such as ear, neck, axilla, and upper extremities, and has been reported as disseminated rosacea.

    Main Observation: A 40-year-old Japanese female presented with one-month history of erythematous skin eruption with burning sensation on the face, neck, and upper limbs. Read More

    Alcohol intake and risk of rosacea in US women.
    J Am Acad Dermatol 2017 Jun 20;76(6):1061-1067.e2. Epub 2017 Apr 20.
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island. Electronic address:
    Background: The epidemiologic association between alcohol and rosacea is unclear and inconsistent based on the previous cross-sectional or case-control studies.

    Objective: We conducted a cohort study to determine the association between alcohol intake and the risk of rosacea in women.

    Methods: A total of 82,737 women were included from the Nurses' Health Study II (1991-2005). Read More

    Minocycline-Induced Hyperpigmentation in a Patient Treated with Erlotinib for Non-Small Cell Lung Adenocarcinoma.
    Case Rep Oncol 2017 Jan-Apr;10(1):156-160. Epub 2017 Feb 15.
    Walter Reed National Military Medical Center, Bethesda, MD, USA.
    Introduction: While epidermal growth factor receptor (EGFR) inhibitors have improved progression-free survival in patients with non-small cell lung cancer (NSCLC), one of the most common adverse effects is papulopustular skin eruption, which is frequently severe enough to be treated with oral minocycline or doxycycline.

    Case: We present a case of an 87-year-old man who developed a severe papulopustular skin eruption secondary to erlotinib therapy for NSCLC. Control of the eruption with 100 mg of minocycline twice daily for 8 months eventually led to blue-gray skin hyperpigmentation. Read More

    [Granulomatous periocular eruption].
    Ann Dermatol Venereol 2017 Jun - Jul;144(6-7):430-433. Epub 2017 Apr 12.
    Clinique universitaire de dermatologie, allergologie et photobiologie, CHU de Grenoble, boulevard de la Chantourne, 38700 La Tronche, France.
    Background: Herein, we report a case of atypical periorificial dermatitis in a patient that had been receiving treatment for some time for atopic dermatitis. The specific feature of this rash was its periocular predominance with no perioral involvement, its clinical aspect and its histological picture evocative of sarcoidosis.

    Patients And Methods: A 33-year-old man was being treated for a atopic dermatitis limited to the face and poorly responsive to dermal corticosteroids. Read More

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