4,095 results match your criteria Rosacea


Efficacy and Safety Results of Micellar Water, Cream and Serum for Rosacea in comparison to a control group.

J Cosmet Dermatol 2020 Jul 5. Epub 2020 Jul 5.

Department of Dermatology and Allergy, University Hospital of Munich, LMU, Munich, Germany.

Background: Rosacea is a common inflammatory skin disorder with centrofacial erythema, flushing, telangiectasia, papules/pustules and possible ocular or phymatous manifestation. Patients' skin is particularly sensitive to chemical and physical stimuli leading to burning, stinging, dryness and skin tightness.

Objective: Dermatological evaluation of the efficacy and safety of skin care products designed for centrofacial erythema in rosacea patients, in comparison to a control group using objective measurements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13591DOI Listing

A rare case of lupoid leishmaniasis defying diagnosis for a decade.

J Cutan Pathol 2020 Jul 4. Epub 2020 Jul 4.

Yale University School of Medicine Department of Dermatology.

Cutaneous leishmaniasis is a common disease affecting millions in endemic areas worldwide. We present a case of lupoid leishmaniasis, a rare variant of cutaneous leishmaniasis, which clinically mimicked sarcoidosis and/or granulomatous rosacea for ten years until ultimate diagnosis. An 82-year-old U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cup.13793DOI Listing

Rosacea and the cardiovascular system.

J Cosmet Dermatol 2020 Jul 3. Epub 2020 Jul 3.

Vernova Healthcare CIC, Macclesfield, UK.

Rosacea and the cardiometabolic syndrome are both associated with chronic inflammation and a pro-inflammatory phenotype. Emerging clinical evidence supports the relationship between rosacea and cardiometabolic syndrome hypertension and obesity. This article reviews our current findings and understanding in the skin and cardiovascular relationship in rosacea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13587DOI Listing

Rosacea induced by selexipag in a patient with pulmonary arterial hypertension.

Dermatol Ther 2020 Jul 2:e13947. Epub 2020 Jul 2.

Dermatology Department, Ramon y Cajal University Hospital, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13947DOI Listing

Use of proton pump inhibitors and risk of rosacea: A nationwide population-based study.

J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Proton pump inhibitors (PPI) are commonly used drugs. However, little is known about the association between PPI use and rosacea. This study aimed to investigate the association between PPI use and rosacea risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15478DOI Listing

Excessive cleansing: an underestimating risk factor of rosacea in Chinese population.

Arch Dermatol Res 2020 Jun 27. Epub 2020 Jun 27.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Appropriate skincare is essential in the prevention and management of rosacea. We sought to investigate whether cleansing habits, the initial step of skin care, would influence the onset and progression of rosacea and their associations with clinical features of rosacea in the Chinese population. We analyzed the daily cleansing habits data collected from 999 rosacea cases and 1010 skin-healthy controls from China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00403-020-02095-wDOI Listing

Color Doppler Ultrasound Evaluation of Management of Papulopustular Rosacea.

J Am Acad Dermatol 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, Faculty of Medicine, Universidad de Chile, Santiago, Chile; Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Santiago, Chile.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.06.068DOI Listing

Update on the pathogenesis and management of ocular rosacea: an interdisciplinary review.

Eur J Ophthalmol 2020 Jun 25:1120672120937252. Epub 2020 Jun 25.

Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL, USA.

Purpose: Rosacea is one of the most common conditions affecting the ocular surface. The purpose of this review is to provide an update on the pathogenesis and treatment of rosacea based on the dermatology and ophthalmology literatures.

Methods: Literature searches were conducted for rosacea and ocular rosacea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672120937252DOI Listing

[Treatmentof rhinophyma with laser and surgery].

Ugeskr Laeger 2020 Jun;182(25)

Rhinophyma is a disfiguring skin condition characterised by progressive hyperplasia of the nasal sebaceous glands and proliferation of blood vessels and connective tissue. It is considered the end stage of rosacea and affects primarily older males of Northern European descent. Several surgical and laser treatment options are available. Read More

View Article

Download full-text PDF

Source

Doxycycline: From Ocular Rosacea to COVID-19 Anosmia. New Insight Into the Coronavirus Outbreak.

Front Med (Lausanne) 2020 8;7:200. Epub 2020 May 8.

Department of Radiation Oncology, IRCCS San Matteo Polyclinic Foundation, Pavia, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2020.00200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225523PMC

United States Stock Market Response to FDA Approval of New Dermatologic Drugs

J Drugs Dermatol 2020 06;19(6):639-645

Background: The Food and Drug Administration (FDA) has approved several new dermatologic drugs in the last decade. The public response to their approval has not yet been evaluated.

Objective: To analyze the United States stock market response surrounding FDA approval of new dermatologic drugs between 2008 and 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.36849/JDD.2020.5033DOI Listing

Treating Inflammation in Rosacea: Current Options and Unmet Needs.

J Drugs Dermatol 2020 Jun;19(6):585-591

Rosacea is a disease resulting from dysregulation of innate, adaptive, and neurovascular immune systems. Inflammatory pathways activated in rosacea can explain many of its signs and symptoms. Current treatments address some of these inflammatory processes, alleviating erythema and decreasing papules and pustules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.36849/JDD.2020.10.36849/JDD.2020.5187DOI Listing

Virtual Exams No Substitute for In-Person Care of Acne and Rosacea.

Authors:

J Drugs Dermatol 2020 Jun;19(6):582

View Article

Download full-text PDF

Source

Value of GPSkin for the measurement of skin barrier impairment and for monitoring of rosacea treatment in daily practice.

Skin Res Technol 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Stratum corneum hydration (SCH) and transepidermal water loss (TEWL) provide useful information about skin barrier function. This study aimed to determine the value of GPSkin Pro, a new handheld device determining both SCH and TEWL, to measure skin barrier impairment and to monitor barrier function in rosacea in daily practice.

Materials And Methods: Two pilots were performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/srt.12900DOI Listing

Rosacea Patients Are at Higher Risk for Obstructive Sleep Apnea: Automated Retrospective Research.

Stud Health Technol Inform 2020 Jun;270:1381-1382

Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, USA.

Using big data science we employ NLP and a novel interface the BMI Investigator to answer clinically meaninful questions. The use case presented is the association between Rosacea and Obstructive Sleep Apnea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/SHTI200452DOI Listing

The role of kallikreins in inflammatory skin disorders and their potential as therapeutic targets.

Crit Rev Clin Lab Sci 2020 Jun 22:1-16. Epub 2020 Jun 22.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.

The skin is a vital organ of the human body, serving numerous protective and functional roles that are essential for survival. Residing in the epidermis are various epidermal proteases responsible for the establishment and regulation of barrier function. The human tissue kallikrein-related peptidase family conserves homeostasis of the skin barrier through their roles in desquamation, antimicrobial defense, innate immune response, and barrier maintenance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10408363.2020.1775171DOI Listing

Rosacea Treatment Satisfaction: Matching Adjusted Indirect Treatment Comparison Analysis of Metronidazole Gel or Cream vs Azelaic Acid Foam.

J Drugs Dermatol 2020 Mar;19(3):295-304

Objective: To assess differences in patient-reported treatment side effects and concerns associated with azelaic acid 15% foam (AAF) vs metronidazole cream (MC) and metronidazole gel (MG).

Methods: This study used matching-adjusted indirect comparison (MAIC) to compare patient-reported outcomes from survey data evaluating rosacea treatments. Outcomes of interest included percentages of patients reporting concerns and side effects and measures of importance of the concerns and tolerability of the side effects. Read More

View Article

Download full-text PDF

Source

Evaluation of a simple image-based tool to quantify facial erythema in rosacea during treatment.

Skin Res Technol 2020 Jun 14. Epub 2020 Jun 14.

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Facial erythema is a common symptom in rosacea. To overcome subjectivity in scoring erythema severity, objective redness quantification is desirable. This study evaluated an image-based erythema quantification tool to monitor facial erythema in rosacea patients during treatment and compared these values to clinical scores. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/srt.12878DOI Listing

Bacterial and fungal microbiome characterization in patients with rosacea and healthy controls.

Br J Dermatol 2020 Jun 13. Epub 2020 Jun 13.

Department of Dermatology, Peking University First Hospital, Beijing, China.

Rosacea is a common inflammatory skin disease, but its pathophysiology is still unclear. Several microorganisms, including Cutibacterium acnes, Demodex spp. and Staphylococcus epidermidis, have been suggested to play roles in its pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.19315DOI Listing

Topical antibiotics in the dermatological clinical practice: indications, efficacy and adverse effects.

Dermatol Ther 2020 Jun 12:e13824. Epub 2020 Jun 12.

Department of Biomedical Sciences and Human Oncology, Section of Dermatology, University of Bari, Bari, Italy.

Topical antibiotic therapy is a central component of patient management for several skin conditions, including acne, hidradenitis suppurativa, rosacea, impetigo or other superinfected dermatitis, prevention of wound infections. Moreover, particular situations, such as skin diseases of bacterial origin in pregnancy and infants often warrant topical therapy. However, the occurrence of local delayed hypersensitivity reactions and the rising rate of antibiotic resistance are becoming great challenges faced by many dermatologists today. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13824DOI Listing

Red scrotum syndrome: An update on clinicopathological features, pathogenesis, diagnosis and management.

J Am Acad Dermatol 2020 Jun 1. Epub 2020 Jun 1.

Dermatology Department, American University of Beirut Medical Center, Lebanon. Electronic address:

The genital skin may be affected by a variety of dermatoses, be it inflammatory, infectious, malignant, idiopathic or others. The Red Scrotum Syndrome is characterized by persistent erythema of the scrotum associated with a burning sensation, hyperalgesia, and itching. Its cause is unknown but proposed mechanisms include rebound vasodilation following prolonged topical corticosteroid use and localized erythromelalgia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.05.113DOI Listing

Assessment of the abdominal fat index by ultrasonography in patients with rosacea.

Australas J Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology, Şişli Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.13337DOI Listing

Study of Clinical Profile of Patients Presenting with Topical Steroid-Induced Facial Dermatosis to a Tertiary Care Hospital.

Indian Dermatol Online J 2020 Mar-Apr;11(2):208-211. Epub 2020 Mar 9.

Department of Skin and Vd, SCB Medical College and Hospital, Cuttack, Odisha, India.

Background: Topical corticosteroids (TCs) are widely used for various indications in dermatology. However, these can cause a plethora of symptoms if overused or abused. Topical steroid damaged face is a relatively new entity which was described in 2008. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_259_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247645PMC

Rosacea and perioral dermatitis: a single-center retrospective analysis of the clinical presentation of 1032 patients.

J Dtsch Dermatol Ges 2020 Jun 29;18(6):561-570. Epub 2020 May 29.

Department of Dermatology and Allergy, Hospital of the Ludwig Maximilian University of Munich, Munich, Germany.

Background: Rosacea is a common chronic inflammatory cutaneous disorder affecting nearly 5.5 % of the adult population. Our aim was to evaluate the prevalence and epidemiology of rosacea and perioral dermatitis (POD) in an ambulatory care setting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ddg.14120DOI Listing

Surgical mask dermatitis caused by formaldehyde (releasers) during the COVID-19 pandemic.

Contact Dermatitis 2020 May 28. Epub 2020 May 28.

Department of Dermatology, University Hospital Antwerp (UZA), Antwerp, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cod.13626DOI Listing

Out of the Blue: A Case of Blue Subungual Discoloration Associated with Prolonged Tetracycline Use.

Cureus 2020 Apr 24;12(4):e7810. Epub 2020 Apr 24.

Family Medicine, University of South Florida, Tampa, USA.

Tetracycline derivatives are antibiotics such as minocycline and doxycycline that have been commonly utilized for inflammatory dermatological conditions such as acne and rosacea. Hyperpigmentation of the skin, nails, thyroid, oral mucosa, teeth, and bones is a known but rare side effect of prolonged tetracycline use. The hyperpigmentation typically takes months to years to develop. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249753PMC

Cutaneous Exophiala oligosperma infection presenting with multiple, rosacea-like papules on the cheek in a healthy individual.

J Dermatol 2020 May 28. Epub 2020 May 28.

Department of Dermatology, Tokyo Medical University School of Medicine, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15418DOI Listing

Topical ivermectin-metronidazole gel therapy in the treatment of blepharitis caused by Demodex spp.: A randomized clinical trial.

Cont Lens Anterior Eye 2020 May 24. Epub 2020 May 24.

Department of Ophthalmology, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia.

Purpose: To evaluate the efficacy of topical ivermectin-metronidazole combined therapy in the management of Demodex-associatedblepharitis.

Methods: Sixty patients with a diagnosis of Demodex-associatedblepharitis were recruited in a randomized clinical trial. Thirty receiving topical ivermectin (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clae.2020.04.011DOI Listing

Psychological Consequences of the Most Common Dermatoses: Data from the Objectifs Peau Study.

Acta Derm Venereol 2020 Jun 11;100(13):adv00175. Epub 2020 Jun 11.

Department of Dermatology and Venereology, University Hospital of Brest, FR-29200 Brest, France. E-mail:

The prevalence of psychological disorders in patients with common skin diseases was assessed in a large representative sample of the French adult population. General health, as measured by the EQ5D score, was significantly lower if patients reported having rosacea, atopic dermatitis, urticaria, fungal infections, psoriasis or acne. The proportions of participants reporting being extremely anxious or depressed were higher in those who reported having rosacea, atopic dermatitis or contact dermatitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3531DOI Listing

An altered fecal microbial profiling in rosacea patients compared to matched controls.

J Formos Med Assoc 2020 May 20. Epub 2020 May 20.

Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Translational Research, Center of Excellence for Cancer Research, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Biomedical Informatics and Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan; National Institute of Cancer Research, National Health Research Institutes, Maioli, Taiwan; Taiwan Microbiota Consortium, Taipei, Taiwan. Electronic address:

Background/purpose: Rosacea has been linked to inflammatory bowel disease and small bowel bacterial overgrowth. We aimed to investigate the fecal microbial profiling and the potential gene functions between rosacea and non-rosacea subjects.

Methods: A case-control study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfma.2020.04.034DOI Listing

Role of ferritin in pathogenesis of rosacea and its value in efficacy of 595 nm pulsed dye laser in treatment of different variants of rosacea: a clinical and immunohistochemical study.

J Cosmet Laser Ther 2020 May 22:1-7. Epub 2020 May 22.

Dermatology and Venereology Department, Tanta University Faculty of Medicine , Tanta, Egypt.

Background: Current rosacea treatment focused on symptom suppression to improve patient's quality of life, prevent progression, and sustain remission. The progress of laser therapy has brought about a paradigm shift in the world of treating erythema and telangiectasia. We appraised role of ferritin in pathogenesis of rosacea and consider its value in efficacy of 595 nm pulsed dye laser (PDL) in treatment of rosacea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14764172.2020.1761549DOI Listing

Efficacy and safety of hydroxychloroquine for treatment of patients with rosacea: a multi-center, randomized, double-blind, double-dummy, pilot study.

J Am Acad Dermatol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Central South University, Changsha, Hunan, China; Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.05.050DOI Listing

Radiofrequency irradiation attenuates angiogenesis and inflammation in UVB-induced rosacea in mouse skin.

Exp Dermatol 2020 May 20. Epub 2020 May 20.

Department of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon, 21936, Republic of Korea.

Rosacea is a skin inflammatory condition accompanied by cutaneous signs such as edema, flushing, erythema, telangiectasia, and pustules. Generally, rosacea is triggered by ultraviolet B (UVB) exposure. When exposed to UVB, skin epidermis thickens and produces elevated levels of pro-inflammatory cytokines, especially keratinocyte-related VEGF, a potent angiogenic factor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.14115DOI Listing

Expressions of glutathione S-transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea.

J Cosmet Dermatol 2020 May 20. Epub 2020 May 20.

Department of Dermatology, Medical Faculty, Istanbul Medeniyet University, Göztepe Research and Training Hospital, Istanbul, Turkey.

Background: Data point to the importance of oxidative stress in rosacea. Glutathione S-transferases (GSTs) have substantial roles in a wide variety of oxidative stress-related conditions.

Aim: To evaluate the immunohistochemical staining characteristics of GST alpha (GSTA), mu (GSTM), pi (GSTP), and theta (GSTT) in patients with rosacea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13501DOI Listing

Magnitude, characteristics and consequences of topical steroid misuse in rural North India: an observational study among dermatology outpatients.

BMJ Open 2020 May 18;10(5):e032829. Epub 2020 May 18.

Nossal Institute for Global Health, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Introduction: Current evidence indicates an alarming increase in topical steroid (TS) misuse in India. Data regarding the magnitude and characteristics of this problem in rural India, where 68% of the population resides, are insufficient. This study analyses the magnitude, causes, characteristics and consequences of TS misuse in rural India. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2019-032829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239529PMC

Effectiveness of benzyl benzoate treatment on clinical symptoms and Demodex density over time in patients with rosacea and demodicosis: a real life retrospective follow-up study comparing low- and high-dose regimens.

J Dermatolog Treat 2020 Jun 15:1-10. Epub 2020 Jun 15.

Institut de Recherche Interdisciplinaire en Biologie humaine et moléculaire (IRIBHM) & Service de Biostatistique et Informatique médicale (SBIM), Université Libre de Bruxelles (ULB), Brussels, Belgium.

Patients with rosacea and demodicosis have high facial skin Demodex densities (Dds), which decrease with benzyl benzoate (BB) treatment. To evaluate the impact of topical BB (+crotamiton) treatment on Dds and clinical symptoms during prolonged follow-up and to compare low (12% once daily) and high (12% twice daily or 20-24% once daily) BB dose regimens. This retrospective study included 344 patients (103 rosacea, 241 demodicosis) observed for 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2020.1770168DOI Listing

Rosacea is associated with conjoined interactions between physical barrier of the skin and microorganisms: A pilot study.

J Clin Lab Anal 2020 May 17:e23363. Epub 2020 May 17.

Research and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC INSERM 1431), University Hospital of Besançon, Besançon, France.

Background: Rosacea is a common condition characterized by transient or persistent central facial erythema, and often papules and pustules. Currently, the role of bacterium in the development and progression of rosacea remains controversial. This study aimed to investigate the difference in the physiological conditions and microorganisms between the lesional and non-lesional areas of papulopustular rosacea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcla.23363DOI Listing

Frontal Fibrosing Alopecia: A Retrospective Study of 75 Patients.

Actas Dermosifiliogr 2020 May 14. Epub 2020 May 14.

Servicio de Dermatología, Hospital Universitario Infanta Sofía, Madrid, España.

Background And Objective: Frontal fibrosing alopecia is an increasingly common form of scarring alopecia. The aim of this study was to describe the demographic and clinical characteristics of patients with FFA seen at the trichology unit of a medium-sized regional hospital and to report on treatments used.

Material And Method: We reviewed the medical records of all patients with FFA seen at the trichology unit of Hospital Universitario Infanta Sofía in Madrid, Spain between May 2016 and May 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ad.2020.03.003DOI Listing

Cigarette smoking and risk of rosacea: a nationwide population-based cohort study.

J Eur Acad Dermatol Venereol 2020 May 13. Epub 2020 May 13.

Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Most evidence regarding the relationship between cigarette smoking and risk of rosacea is obtained from cross-sectional or case-control studies.

Objective: To examine the association between smoking and risk of developing rosacea.

Methods: Participants were collected from four rounds (2001, 2005, 2009 and 2013) of the Taiwan National Health Interview Survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16595DOI Listing
May 2020
2.826 Impact Factor

Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses.

Front Immunol 2020 24;11:703. Epub 2020 Apr 24.

Department of Physiology, Michigan State University, East Lansing, MI, United States.

Mast cells are tissue-resident innate immune cells known for their prominent role in mediating allergic reactions. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a promiscuous G-protein coupled receptor (GPCR) expressed on mast cells that is activated by several ligands that share cationic and amphipathic properties. Interestingly, MRGPRX2 ligands include certain FDA-approved drugs, antimicrobial peptides, and neuropeptides. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194083PMC

Effect of treatment with silver(I) complex of metronidazole on ocular rosacea: Design and formulation of new silver drug with potent antimicrobial activity.

J Trace Elem Med Biol 2020 Apr 17;61:126531. Epub 2020 Apr 17.

Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, Poland. Electronic address:

Background: Metronidazole with well-soluble silver nitrate forms a complex with potent activity (synergism) against bacterial strains and fungi with simultaneous lower side effect than in the case of the two agents administered separately. This study aimed to establish effectiveness in the treatment of ocular rosacea with new formulation of drops and ointment with silver(I) complex of metronidazole.

Methods: Three patients suffering from serious ophthalmic complications of acne rosacea were treated with drops and ointments applied 3 times a day for 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtemb.2020.126531DOI Listing

Relationship between the incidence of rosacea and drinking or smoking in China.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):165-168

Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China

Objectives: To explore the relationship between the incidence of rosacea and drinking, smoking, gender or age, and to provide some basis for the diagnosis, treatment and mechanism of rosacea.

Methods: A total of 1 180 patients with rosacea and 1 008 non-rosacea patients diagnosed in the Department of Dermatology of Xiangya Hospital were included in the study. Logistic analysis was performed on the incidence factors, and the differences between the two groups in different age groups were compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180759DOI Listing
February 2020

Oxymetazoline and Energy-Based Therapy in Patients with Rosacea: Evaluation of the Safety and Tolerability in an Open-Label, Interventional Study.

Lasers Surg Med 2020 May 6. Epub 2020 May 6.

Aclaris Therapeutics, Inc., 640 Lee Road, Suite 200, Wayne, Pennsylvania, 19087.

Background And Objectives: The objectives of this study were to evaluate the safety, tolerability, and efficacy of oxymetazoline hydrochloride cream, 1% (oxymetazoline) when used as an adjunctive treatment with energy-based therapy for patients with moderate to severe facial erythema associated with rosacea.

Study Design/materials And Methods: In this Phase 4, multicenter, interventional, open-label study, eligible patients received one of four energy-based therapies (potassium titanyl phosphate laser, intense pulsed light therapy, pulsed-dye laser Vbeam Perfecta, or pulsed-dye laser Cynergy) on day 1 and day 29 and once-daily application of oxymetazoline on days 3 through 27 and days 31 through 56. Improvement from baseline in Clinician Erythema Assessment (CEA) score, patient satisfaction measures, incidence of treatment-emergent adverse events (TEAEs), and worsening from baseline on dermal tolerability assessments and the Clinician Telangiectasia Assessment (CTA) were assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lsm.23253DOI Listing

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands.

Ocul Surf 2020 May 4. Epub 2020 May 4.

Section of Academic Ophthalmology, School of Life Course Sciences, Faculty of Life Sciences and Medicine (FoLSM), King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, United Kingdom; Department of Ophthalmology, King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, London, United Kingdom.

Purpose: To investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories.

Methods: A cross-sectional association study including 79,866 voluntary participants aged 20-94 years of the population-based Lifelines Cohort Study in the Netherlands.

Results: Overall, 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtos.2020.04.005DOI Listing

A Preliminary Clinical Evaluation of a Topical Product for Reducing Slight Rosacea Imperfections.

Clin Cosmet Investig Dermatol 2020 21;13:299-308. Epub 2020 Apr 21.

Bio Basic Europe Srl, Milan, Italy.

Introduction: Rosacea is a chronic multifactorial skin disorder mainly affecting facial skin with an estimated prevalence of about 5% worldwide. Its main symptoms, occurring early during pathology development, are skin dehydration, redness, erythema, and telangiectasia. Given the lack of a resolutive cure, therapeutic approaches able to relieve the main symptoms are needed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CCID.S240784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183761PMC

An exploratory, open-label, investigator-initiated study of interleukin-17 blockade in patients with moderate-to-severe papulopustular rosacea.

Br J Dermatol 2020 May 4. Epub 2020 May 4.

Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.19172DOI Listing

Prevalence, clinical characteristics and health-related quality of life of rosacea in Chinese adolescents: a population-based study.

J Eur Acad Dermatol Venereol 2020 May 3. Epub 2020 May 3.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16576DOI Listing
May 2020
2.826 Impact Factor

Use of beta-blockers for rosacea-associated facial erythema and flushing: a systematic review and update on proposed mode of action.

J Am Acad Dermatol 2020 Apr 29. Epub 2020 Apr 29.

Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Flushing and erythema are frequent skin symptoms in rosacea. As their adequate treatment remains a clinical challenge, new treatment options are explored, such as oral β-blockers.

Objective: To evaluate the efficacy of oral β-blockers for rosacea-associated facial flushing and erythema. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.04.129DOI Listing