2,309 results match your criteria Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie[Journal]


Correlations on the protection of personal data and intellectual property rights in medical research.

Rom J Morphol Embryol 2018 ;59(3):1001-1005

Department of Intellectual Property Law, Law School, University of Craiova, Romania;

Purpose: International regulations regarding the protection of individuals concerning the processing of personal data and the free movement of such data highlight the need for their systematization and customization, depending on the purpose for which they are collected and used.

Background: Medical legislation is structured so that the constitutional right to healthcare is guaranteed and at the same time be protected by respecting the right to privacy with respect to identity, physiological state of the person and the way this, by health maneuvers, was restored. European Union (EU) legislation is more and more complex related to the patients' right and also to the General Data Protection Regulation (GDPR). Read More

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January 2019
5 Reads

Compound odontoma - morphology, clinical findings and treatment. Case report.

Rom J Morphol Embryol 2018 ;59(3):997-1000

Department of Ergonomics and Scientific Research Methodology, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Eforiei Dental Clinic, Bucharest, Romania;

Compound odontomas are benign tumors, composed of odontogenic tissue that has an orderly pattern. These are formed of unilocular conglomerate of multiple calcified structures, some resembling to mini-teeth. A case of a 9-year-old female patient with compound odontoma is reported, highlighting aspects of odontoma's morphology, clinical findings and treatment. Read More

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January 2019
4 Reads

Basal cell carcinoma and basosquamous carcinoma, two faces of the same condition?

Rom J Morphol Embryol 2018 ;59(3):989-996

Department of Microscopic Morphology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania; Department of Otorhinolaryngology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

Basal cell carcinoma (BCC) is the most common locally invasive malignant epidermal neoplasm. It is generally a tumor that runs a slow progressive course and can usually be cured by surgery. Basosquamous carcinoma is considered by some authors a rare subtype of BCC, while others describe it as independent tumor with different evolution from BCC. Read More

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January 2019
6 Reads

Double autosomal trisomy with mosaicism 47,XY(+8)∕47,XY(+21). Morphological and genetic changes of a rare case.

Rom J Morphol Embryol 2018 ;59(3):985-988

Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Romania;

The co-occurrence in the same individual of two numerical chromosomal abnormalities (double aneuploidy) is a very rare condition, especially for autosomes. Clinical presentations are variable depending on the predominating aneuploidy. The authors present a rare case of a male infant with multiple congenital anomalies: craniofacial dysmorphism, short neck, agenesis of the corpus callosum, ventricular septal defect, bilateral broad hallux, large first interdigital space of the toes, plantar furrows, prominent calcaneus and right kidney agenesis. Read More

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January 2019
19 Reads

Mixed (nodular and morpheic) upper eyelid basal cell carcinoma with orbital invasion - histological and clinical features.

Rom J Morphol Embryol 2018 ;59(3):977-983

Department of Plastic Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

Basal cell carcinoma (BCC) is the most common type of cancer located in the periocular area. We will present the clinical case of a 63-year-old male patient who was admitted to the 2nd Clinic of Neurosurgery, "Prof. Dr. Read More

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January 2019
7 Reads

An unusual cause of acute surgical abdomen: benign multicystic peritoneal mesothelioma associated with adenomatous tumor.

Rom J Morphol Embryol 2018 ;59(3):971-976

Department of Human Anatomy, University of Medicine and Pharmacy of Craiova, Romania;

Benign multicystic peritoneal mesothelioma (BMPM) is a rare disease that primarily affects fertile women with previous abdominal surgery. BMPM associated with adenomatous tumor is a single case report, according to our opinion. The patient had a history of abdominal surgery nine years ago for ovarian cysts. Read More

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January 2019
3 Reads

The importance of the histopathological examination in lethal acute intoxication with ethylene glycol. Case report.

Rom J Morphol Embryol 2018 ;59(3):965-969

Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Romania;

Ethylene glycol is a toxic alcohol that is mainly introduced into an organism through the digestive pathway. Its priority toxic metabolites are glycolic acid and oxalic acid. We present the case of a young person, of the male persuasion, without any personal pathological history, found unconscious and presenting signs of violence. Read More

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January 2019
5 Reads

Translational approaches in treatment-resistant depression based on animal model.

Rom J Morphol Embryol 2018 ;59(3):955-964

Department of Psychiatry, "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania;

An intensively researched and yet poorly understood phenomenon, both at clinical and neurobiological level, is the determinism of treatment-resistant depression. Even more controversial are the stages of approaching therapeutically this pathology because there are no evidence-based recommendations stating that a pharmacological agent is superior to another, on medium and long-term. Due to the lack of "golden standard" approaches, physician's experience, therapeutic alliance and a close monitoring stand as the most useful good practices in the treatment of resistant depression. Read More

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January 2019
8 Reads

Non-invasive imaging techniques for early diagnosis of radiation-induced squamous cell carcinoma of the lip.

Rom J Morphol Embryol 2018 ;59(3):949-953

"Victor Babeş" National Institute for Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania;

Ionizing radiation was used in the past for treatment of several benign cutaneous conditions, and particularly hemangiomas. Even though radiotherapy was generally effective, it significantly augmented the risk for malignancies, resulting in a consequent heavy decline of its use for benign conditions. However, radiation-induced neoplasia is still encountered in adult patients irradiated during childhood or adolescence. Read More

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January 2019
6 Reads

Clinical and genetic diversity of congenital hyperammonemia.

Rom J Morphol Embryol 2018 ;59(3):945-948

Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Romania;

Congenital hyperammonemia (HA) due to inborn errors of metabolism is a rare condition with a high rate of mortality. The main effects occur at the central nervous system (CNS) level, being neurotoxic by alteration of the neurotransmitter function. HA can be triggered by an inappropriate diet, infection or stress, but can also occur without a precise cause. Read More

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January 2019
3 Reads

The acute abdomen in pregnancy and postpartum of a teenager woman. Case report.

Rom J Morphol Embryol 2018 ;59(3):939-943

Department of Pediatric Surgery, University of Medicine and Pharmacy of Craiova, Romania; Department of General Surgery, University of Medicine and Pharmacy of Craiova, Romania;

The acute abdomen with its many clinical aspects is not a condition that eludes pregnancy; acute appendicitis being the most frequently incriminated, but when it comes to its complication - peritonitis and the pregnant is a teenager, the cases cited in the literature are quite rare. We present the case of a 15-year-old teenager pregnant within 24 weeks admitted from the emergency department with the diagnosis of acute abdomen and operated for generalized peritonitis due to a perforated appendicitis. The microscopic analysis of the specimen indicated the presence of ulceration and extensive and deep and necrosis of the appendicle wall, the residual structures being dissected by a predominantly polymorphonuclear leukocytes inflammatory infiltrate associated with eosinophilic fibrinous deposits. Read More

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January 2019
5 Reads

Endometrial stromal sarcoma in a 27-year-old woman. Case report and literature review.

Rom J Morphol Embryol 2018 ;59(3):933-938

Department of Obstetrics-Gynecology and Neonatology, "Carol Davila" University of Medicine and Pharmacy, Department of Obstetrics and Gynecology, "St. John" Emergency Clinical Hospital, Bucharest, Romania;

Endometrial stromal tumors are very rare, representing approximately 0.2% of uterine malignancies, having an incidence of one to two from a million of women. The diagnosis cannot be established by imaging, it is histopathological only, often necessitate supplementary immunohistochemistry tests. Read More

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January 2019
16 Reads
0.659 Impact Factor

Chondrosarcoma of the pelvis - case report.

Rom J Morphol Embryol 2018 ;59(3):927-931

Department of Obstetrics and Gynecology, University Emergency Hospital of Bucharest, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Chondrosarcoma (CHS) is the third most common primary bone tumor after myeloma and osteosarcoma. Histologically, it is made of pure hyaline cartilage differentiation. The tumor itself may have myxoid modification and calcification. Read More

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January 2019
4 Reads

A patient with pilomatricoma in the parotid region: case report and review of the literature.

Rom J Morphol Embryol 2018 ;59(3):917-926

Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;

Pilomatricoma is a benign skin tumor originating from the matrix cells of the hair follicles. Sometimes, its diagnosis can be difficult, especially in the preauricular region, where in the differential diagnosis, in addition to other dermal and subcutaneous masses, primary and secondary parotid gland tumor lesions must be also considered. A 34-year-old female was referred to our Institution with a right preauricular swelling over 12 months, which enlarged in the last two months. Read More

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January 2019
16 Reads

Multidisciplinary approach of assessing malformed fetuses exemplified in a rare case of pentalogy of Cantrell associated with craniorachischisis, pulmonary extrophy and right-sided aortic arch with aberrant brachiocephalic artery.

Rom J Morphol Embryol 2018 ;59(3):911-915

1st Department of Obstetrics and Gynecology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania;

We present the imagistic and pathological assessment of a unique case of complete pentalogy of Cantrell associated with craniorachischisis, pulmonary extrophy and right-sided aortic arch with aberrant brachiocephalic artery. For this particular case, the complete and correct diagnosis required a post-mortem imagistic high-resolution magnetic resonance imaging (MRI) at 7 T and detailed stereomicroscopic autopsy. Also, we discussed the pathogenesis and possible etiology of pentalogy of Cantrell and the associated malformations of the case presented. Read More

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January 2019
4 Reads

A rare cause of ischemic stroke: cardiac myxoma. Case report and review of literature.

Rom J Morphol Embryol 2018 ;59(3):903-909

Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania;

A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosis and produced severe pulmonary hypertension. Read More

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January 2019
8 Reads

Diabetic foot - epidemiological and histopathological aspects.

Rom J Morphol Embryol 2018 ;59(3):895-902

Department of Physiopathology, Faculty of Medicine, "Titu Maiorescu" University, Bucharest, Romania; Department of Family Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Our study included a total of 259 patients with diabetes, who were admitted to the Department of Plastic Surgery and Reconstructive Microsurgery of the Emergency County Hospital of Piteşti, Romania, in 2016, with the diagnosis of "diabetic foot". Of the 259 patients, 55 (21.23%) were diagnosed with type 1 diabetes, and the remaining 204 (78. Read More

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January 2019
3 Reads

Three-dimensional printing of liver tumors using CT data: proof of concept morphological study.

Rom J Morphol Embryol 2018 ;59(3):885-893

Doctoral School, University of Medicine and Pharmacy of Craiova, Romania;

Introduction: Hepatocellular carcinoma (HCC) currently represents a major health concern, mainly for its shifting pre-existing conditions that in turn lead to late diagnosis, thus increasing the mortality rate. An improved training of medical personnel involved in diagnosis, staging and the management of treatment is required.

Aim: We thus aimed to transition tumor view from two-dimensional, on-screen, methods to real, palpatory three-dimensional (3D) representations that can be printed using generally available tools, thus approachable in virtually any medical setting worldwide. Read More

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January 2019
5 Reads

Non-syndromic hypodontia of permanent dentition associated with other dental anomalies in children and adolescents.

Rom J Morphol Embryol 2018 ;59(3):879-883

Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, Romania;

Anomalies of permanent dentition, by the frequency of the cases, also correspond to some unanimously recognized problems of public health. The objective of this study is to determine the prevalence of non-syndromic hypodontia and oligodontia and to identify the types of associated dental anomalies in the permanent dentition of children and adolescents in the NW of Romania. The study was conducted between 2008 and 2015 on a group of 566 children aged between 12-18 years old. Read More

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January 2019
2 Reads

Morphological study of upper wisdom tooth.

Rom J Morphol Embryol 2018 ;59(3):873-877

Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, Romania;

The article presents aspects of crown and root morphology of the superior wisdom teeth, aiming to several parameters: size, shape crown and occlusal surface, number, topography and orientation of the roots in order to determine which the most common morphological types are. For this purpose, the upper wisdom teeth were collected. According to studies, the dominant form of the dental crown is parallelepipedic, the rectangular or parallelogram shape of the occlusal surface has large mesial and distal-oriented sides. Read More

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January 2019
18 Reads

New perspectives in the use of laser diode transscleral cyclophotocoagulation. A prospective single center observational cohort study.

Rom J Morphol Embryol 2018 ;59(3):869-872

Department of Neurology, "Victor Babeş" University of Medicine and Pharmacy, "Pius Brînzeu" Emergency County Clinical Hospital, Timişoara, Romania; Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Purpose: The paper intends to present the results of using new methods of a new generation diode laser transscleral cyclophotocoagulation (TSCPC) in patients with different types of glaucoma.

Patients, Materials And Methods: There have been treated 53 eyes from 59 patients with glaucoma refractory to medical, laser or surgical treatment. We have used the newest generation of 810 nm wavelength diode laser. Read More

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January 2019
2 Reads

Effect of the laser beam on implant site preparation: a preliminary pilot study.

Rom J Morphol Embryol 2018 ;59(3):861-867

Department of Oral Rehabilitation and Dental Emergencies, Faculty of Dentistry, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

The aim of this preliminary study is to histologically evaluate the effects of erbium-doped yttrium aluminum garnet (Er:YAG) laser on soft and hard tissues during implant bed preparation, in comparison with bur and cutter in order to observe the following aspects: (i) the shape of the cavity, (ii) the presence of debris, and (iii) structural modification of the cell architecture. Bone temperature changes during the preparation of the implant bed were also measured in order to evaluate thermal damage on soft and hard tissues. Er:YAG laser, Fotona X-Runner scanner and circular cutter of 5 mm diameter were compared using an in vitro model. Read More

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January 2019
3 Reads

The evaluation of the morphological evolution of the tissue integration of dental implants through conventional histology and immunohistochemistry techniques.

Rom J Morphol Embryol 2018 ;59(3):851-859

Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Soft peri-implant tissues are important to ensure the integration of a dental implant, and information on their morphophysiology may explain some clinical failures. Through this study, we aim to contribute to a better understanding of the behavior of peri-implant soft tissue, the morphological support being the one that can explain the different clinical situations. Thus, we sought to reconcile clinical, histopathological and immunohistochemical (IHC) aspects of soft peri-implant tissue, in patients who did not show clinical mobility or radiological signs of bone resorption four months after insertion of implants, some of them showing no clinical signs of inflammation. Read More

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January 2019
4 Reads

The prognostic value of CXCR4, α-SMA and WASL in upper lip basal cell carcinomas.

Rom J Morphol Embryol 2018 ;59(3):839-849

Department of Dental Materials, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania;

Lip cancers account for 10-12% of the total head and neck cancers and, although squamous cell carcinoma is by far the most common lower lip cancer, the basal cell carcinoma (BCC) seems to be more common for the upper lip. Most BCCs have a clinically indolent behavior, but there are also local aggressive and∕or metastatic cases, with the incidence of such cases being estimated at about 1-10% of all cases of BCC. Many of the molecular mechanisms underlying this aggression are still unknown, which is why our study aimed to investigate the potential prognosis of a few markers, such as C-X-C chemokine receptor type 4 (CXCR4), alpha-smooth muscle actin (α-SMA) and Wiskott-Aldrich syndrome like (WASL) in upper lip BCCs. Read More

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January 2019
9 Reads

Endoscopic retrograde cholangiopancreatography (ERCP) in patients with periampullary diverticula.

Rom J Morphol Embryol 2018 ;59(3):833-837

Institute of Gastroenterology and Hepatology, Iaşi, Romania;

Aim: The aim of our study was to compare baseline characteristics and clinical data as well as endoscopic retrograde cholangiopancreatography (ERCP) results in patients with and without periampullary diverticulum (PAD).

Patients, Materials And Methods: A single center retrospective analysis was conducted from June 2016 to June 2017 and the patients that had undergone ERCP were divided into two groups, according to the presence (Group A, 43 patients) or absence (Group B, 55 patients) of PAD.

Results: Mean age of patients with PAD was significantly higher than the ones in the control group (69. Read More

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January 2019
4 Reads

Bisphosphonates-induced osteonecrosis of the jaw - epidemiological, clinical and histopathological aspects.

Rom J Morphol Embryol 2018 ;59(3):825-831

Department of Microscopic Morphology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania; Department of ENT, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

Introduction: Osteonecrosis of the jaw (ONJ) is a multifactorial condition associated with bisphosphonates (BPs) treatment, head and neck irradiation, malignancy, chemotherapy, periodontal disease or trauma. The first cases of BPs-related ONJ (BRONJ) were reported over a decade ago.

Patients, Materials And Methods: The study was retrospective and analyzed archived material. Read More

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January 2019
4 Reads

Immunohistochemical analysis of bone metabolism in osteonecrosis of the femoral head.

Rom J Morphol Embryol 2018 ;59(3):819-824

Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania; Urodiamed Clinic, Craiova, Romania;

Osteonecrosis of the femoral head occurs because of the suppression of blood circulation. At the level of the area affected by the ischemic phenomenon, there are two types of events, in the first stage there is necrosis of the cellular elements, followed by a reparatory phase of the spongy bone tissue. The objective of the study was the histological and immunohistochemical (IHC) analysis of bone metabolism in the repair phase. Read More

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December 2018
3 Reads

Histological and immunohistochemical study on the apical granuloma.

Rom J Morphol Embryol 2018 ;59(3):811-817

Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Romania;

Introduction: Periapical granuloma is one of the most frequent periodontal pathology and belongs to the group named as apical periodontitis.

Materials And Methods: Out of 78 of diagnosed granulomas, we selected samples that we analyzed histologically and immunohistochemically.

Results: The histopathological aspect has been dominated by the presence of mononuclear cells of the lymphocyte and plasma cells type, showing the chronic aspect of the apical lesion. Read More

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December 2018
7 Reads

Midpalatal suture morphology and bone density evaluation after orthodontic expansion: a cone-bean computed tomography study in correlation with aesthetic parameters.

Rom J Morphol Embryol 2018 ;59(3):803-809

Department of Orthodontics, Faculty of Dental Medicine, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

Maxillary expansion is one of the earliest methods of obtaining space used in the field of orthodontics. Maturing craniofacial sutures along with the increase in bone density and rigidity are main causes of high resistance of the maxilla to transversal expansion forces applied to the midpalatal suture through orthodontic appliances. Fifty-three patients, with a mean age of 16. Read More

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December 2018
2 Reads

Morphological changes of gums in occlusal trauma.

Rom J Morphol Embryol 2018 ;59(3):787-802

Department of Occlusology and Fixed Prosthetics, University of Medicine and Pharmacy of Craiova, Romania;

Aim: Occlusal trauma causes major modifications of the coverage periodontium, which in turn reflect on the dental unit. The aim of the present study is to evaluate some of the morphological modifications occurred in the marginal periodontium surrounding teeth affected by occlusal trauma.

Materials And Methods: Fragments of marginal periodontium coming from 51 patients with occlusal trauma were processed using classical histological techniques (formalin fixation and paraffin embedment) and stained with Hematoxylin-Eosin (HE), Masson's trichrome and anti-CD34 antibody immunostaining, in order to highlight the epithelial and connective tissue changes of gingival mucosa. Read More

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December 2018
5 Reads

Osseointegration of zirconium dental implants three months after insertion in rabbit femur. Histopathological study.

Rom J Morphol Embryol 2018 ;59(3):781-786

Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Romania;

Implantology is a highly researched field with a constant concern in finding and studying new implant materials. Lately, zirconium has become a very attractive alternative to the detriment of titanium, but the research results were sometimes contradictory. Thus, we considered as opportune to study the osseointegration of zirconium dental implants in rabbit femur, three months after insertion. Read More

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December 2018
3 Reads

Bipolar en bloc tumor resection versus standard monopolar TURBT - which is the best way to go in non-invasive bladder cancer?

Rom J Morphol Embryol 2018 ;59(3):773-780

Department of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital, Clinical Department No. 3, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

The aim of the study was to observe similarities and differences regarding surgical safety and prognosis between en bloc bipolar resection and monopolar transurethral resection of bladder tumors (TURBTs) in medium size papillary non-muscle invasive bladder tumors (NMIBTs). A total of 90 patients with papillary bladder tumors presenting a diameter between 1 and 3 cm were equally divided and alternatively assigned for en bloc bipolar ablation (the study group) and conventional TURBT (the control group). During one year, every three months, the follow-up was performed and the protocol included urinary cytology and cystoscopy. Read More

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December 2018
4 Reads

Assessment of hormonal receptor immunoexpression and Her2 status in invasive breast cancer after conservative and radical surgery.

Rom J Morphol Embryol 2018 ;59(3):763-772

Department of Surgery, University of Medicine and Pharmacy of Craiova, Railroads Hospital of Craiova, Romania; Department of Extreme Conditions Medicine, University of Medicine and Pharmacy of Craiova, Romania;

This study was conducted on 300 patients with infiltrative breast carcinoma, of which 112 cases underwent radical mastectomy, and 188 were conservatively operated. Forty-four patients experienced local relapses during the clinical follow-up. The immunohistochemical (IHC) study used the Labeled Streptavidin Biotin (LSAB)∕Horseradish peroxidase (HRP) method, which evaluated the estrogen receptor (ER) and progesterone receptor (PR), as well as human epidermal growth factor receptor 2 (Her2∕neu) expressions in tumor cells. Read More

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December 2018
4 Reads

Cerebrolysin increases motor recovery and decreases inflammation in a mouse model of autoimmune encephalitis.

Rom J Morphol Embryol 2018 ;59(3):755-762

Department of Research Methodology, University of Medicine and Pharmacy of Craiova, Romania;

Multiple sclerosis (MS) is a complex chronic neurodegenerative disease that involves an abnormal autoimmune response directed against the brain, nerves and spinal cord; it is considered the most frequent cause of neurological disability, because MS-associated inflammatory lesions can affect a wide range of systems to a varying degree and may cause a plethora of neurological comorbidities and symptoms. The symptoms are quite variable from patient to patient and depend on the spatial distribution of the central nervous system (CNS) lesions, but usually involve sensory disturbances, cognitive deficits, unilateral vision loss, bladder dysfunction, ataxia, fatigue, double vision, weakness of the limbs and intestinal disorders. Experimental autoimmune encephalitis (EAE) mouse model reproduces the pathological features of the human disease, and is a widely used model used for studying the pathology and different treatment options in the preclinical stage. Read More

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December 2018
7 Reads

Morphological features predictive for BRAF(V600E) mutation in papillary thyroid microcarcinomas.

Rom J Morphol Embryol 2018 ;59(3):747-753

Department of Histology, University of Medicine and Pharmacy of Tîrgu Mureş, Romania;

Background: The B-Raf proto-oncogene serine∕threonine kinase (BRAF) V600E (BRAF(V600E)) mutation represents a very specific marker for papillary thyroid carcinoma (PTC), including microcarcinomas (PTMCs). However, assessment of the BRAF(V600E) mutational status is expensive and not available in all pathology laboratories.

Aim: We aimed to evaluate if we can identify those morphological features that could predict the presence of the BRAF(V600E) mutation in a series of PTMCs. Read More

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December 2018
1 Read

The utility of indirect imagistic signs in the diagnosis of anterior cruciate ligament ruptures.

Rom J Morphol Embryol 2018 ;59(3):741-745

Discipline of Psychiatry, Department of Neurosciences, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

We conducted a retrospective study, between 2013 and 2018. The study was conducted by analyzing the comparative imaging of two groups of patients. The two groups comprise 42 patients, 14 women and 28 men aged between 17 and 70 years old, to whom objective variables of statistical relevance were tracked. Read More

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December 2018
3 Reads

Quantitative assessment of morphological changes of dental pulp components of teeth affected by occlusal trauma.

Rom J Morphol Embryol 2018 ;59(3):729-740

Department of Occlusology and Fixed Prosthetics, University of Medicine and Pharmacy of Craiova, Romania;

Aim: In the general economy of the stomatognathic system functionality, the occlusal function has an important role, meaning both the dental-dental reports and the dynamic reports interarch-interarch. Because of the interrelationships and inter-dependency that govern the functioning of the biological systems, a pathological change affecting a component of the stomatognathic system produces impaired functioning of the others. The aim of the present study is to assess the morphological changes occurred in the dental pulp components of teeth affected by occlusal trauma. Read More

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December 2018
4 Reads

Prognostic significance of cell-adhesion molecules in histological variants of papillary thyroid carcinoma.

Rom J Morphol Embryol 2018 ;59(3):721-727

Department of Morphofunctional Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

The molecular structure of E-cadherin and its function are intimately related to β-catenin, their interactions ensuring the cell morphology and stability. Alterations of E-cadherin-β-catenin complex facilitate the tumor growth and spreading in the carcinogenic mechanism. We aimed to assess the E-cadherin and β-catenin immunoexpressions in different variants of papillary thyroid carcinoma (PTC), and the relationship of these markers with the clinicopathological prognostic factors. Read More

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December 2018
6 Reads

Placental findings in pregnancies complicated with IUGR - histopathological and immunohistochemical analysis.

Rom J Morphol Embryol 2018 ;59(3):715-720

Department of Anesthesiology and Intensive Care, University of Medicine and Pharmacy of Craiova, Romania; Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Romania;

Objective: Placental lesions and placental ischemia are typical elements of intrauterine growth restriction (IUGR). The aim of this study is to analyze histological and immunohistochemical (IHC) changes in the placentas of IUGR fetuses.

Materials And Methods: In this prospective study, 126 placentas from small for gestational age (SGA) pregnancies (newborns with birth weight <10th percentile) that formed the study group and 31 placentas from pregnancies without SGA representing control group, were included. Read More

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December 2018
7 Reads

Paving the way to tumor budding assessment using digital pathology: a pilot study in Timişoara City (Romania).

Rom J Morphol Embryol 2018 ;59(3):703-713

Department of Microscopic Morphology - Pathology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

Background And Aim: The outcome for some colorectal cancer patients correlates poorly with classical prognostic factors, like tumor stage. Tumor budding (TB) is a promising and intensely studied new prognostic factor. We aimed to evaluate the reliability of bud counting on Hematoxylin-Eosin (HE)-stained and immunohistochemically (IHC)-stained scanned slides. Read More

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December 2018
4 Reads

Histopathological changes in major amputations due to diabetic foot - a review.

Rom J Morphol Embryol 2018 ;59(3):699-702

Discipline of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Diabetes mellitus is the leading cause of non-traumatic amputations worldwide. Ulcer of the diabetic foot is one of the most prevalent lesions of diabetic patients and it occurs in the natural evolution of the disease as a tardive complication. Neuropathy is the main determinant of foot ulcer. Read More

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December 2018
4 Reads

Clinical, histological and therapeutic modern approach of Ledderhose disease.

Rom J Morphol Embryol 2018 ;59(3):691-697

Department of Anesthesiology and Intensive Care, Emergency Clinical Hospital of Bucharest, Romania;

Ledderhose disease or plantar fibromatosis is a rare hyperproliferative disorder of the plantar aponeurosis, clinically characterized by nodules situated especially on the medial border of the foot. It is histopathologically associated with Dupuytren's disease. This disease has some risk factors, like old age, alcohol or nicotine abuse, liver dysfunction, trauma or exposure to vibrations and autoimmune disorders, but the exact etiology is still unknown. Read More

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December 2018
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Diagnostic and therapeutic approaches in oral cavity granulomas based on new data concerning their origin and pathogenesis.

Rom J Morphol Embryol 2018 ;59(3):679-690

Discipline of Histology, Department of Morphological Sciences, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania;

Giant cell granulomas in the oral cavity are reactive hyperplastic lesions that arise either peripherally in the mucoperiosteum or centrally in the bone. The peripheral giant cell granuloma (PGCG) is a benign lesion induced by local chronic irritation. It may develop at any age, and tends to be more frequent in females. Read More

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December 2018
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Aspects regarding nomenclature, classification and pathology of neuroendocrine neoplasms of the digestive system - a review.

Rom J Morphol Embryol 2018 ;59(3):673-678

Department of Surgery, University of Medicine and Pharmacy of Craiova, Surgery Unit, Railway Clinical Hospital, Craiova, Romania;

Neuroendocrine neoplasms (NENs) of the digestive system are composed of cells with a neuroendocrine phenotype. These tumors produce and secrete peptide hormones and biogenic amines and they are called neuroendocrine neoplasms because of the marker proteins that they share with the neural cell system. The classification and nomenclature used to designate NENs have undergone changes over the past decades due to the accumulation of evidence related to the biological characteristics and their evolution. Read More

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December 2018
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Transdifferentiations and heterogeneity in the stromal niches of uterine leiomyomas.

Rom J Morphol Embryol 2018 ;59(3):663-672

Division of Anatomy, Department 1, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Uterine leiomyomas, also known as uterine fibroids (UFs), are benign smooth muscle cells tumors, the most frequent tumors in women. Even though UFs are monoclonal tumors, they contain a heterogeneous and versatile cells population. There are scarce proofs about the processes of transdifferentiation that might occur in UFs, modify the tumor microenvironment and support blood and lymph vessels formation. Read More

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December 2018
3 Reads

Mesenchymal stromal cells derived exosomes as tools for chronic wound healing therapy.

Rom J Morphol Embryol 2018 ;59(3):655-662

Laboratory of Mesenchymal Stromal Progenitor Cells Therapy, Department of Regenerative Medicine, "Nicolae Simionescu" Institute of Cellular Biology and Pathology, Bucharest, Romania;

In modern society, the healing of chronic wounds is still a major cause of discomfort for the patients and a financial burden for the care system. Current approaches use either organic tissue-engineered skin substitutes or stem cells based therapy. It has been shown that mesenchymal stem cells (MSCs) are able to improve the wound healing process by secreting factors with anti-inflammatory, anti-fibrotic and pro-angiogenic activities either as soluble molecules (growth factors, cytokines) or encapsulated within membrane vesicles (microparticles, exosomes). Read More

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December 2018
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Letter to the Editor: Adenomatous oncocytic hyperplasia of labial minor salivary gland duct: age-related or treatment-induced change?

Rom J Morphol Embryol 2018 ;59(2):641-642

Service d'Anatomie Pathologique, AP-HP GHU Avicenne, Université Paris Nord Sorbonne Cité, Bobigny, France;

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December 2018
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Remember: Ambroise Paré (1510-1590) - message for young surgeons.

Rom J Morphol Embryol 2018 ;59(2):637-640

Department of Neurosurgery, Emergency County Hospital Sibiu, Department of Neurosurgery, "Victor Papilian" Faculty of Medicine, "Lucian Blaga" University of Sibiu, Romania;

Ambroise Paré was a renowned French barber-surgeon, considered by many to be "the father of surgery". Originating from a family of barber-surgeons, he unraveled the secrets surgery at an early age, and he masters it by participating in the many military actions of the French Army of those times. As recognition of his merits, the kings of France proclaimed him their chief barber-surgeon and even president of the Royal College of French Surgeons. Read More

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December 2018
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Ethical approach to the genetic, biometric and health data protection and processing in the new EU General Data Protection Regulation (2018).

Rom J Morphol Embryol 2018 ;59(2):631-636

Faculty of Social Sciences, University of Craiova, Romania; Department of Basic, Preventive and Clinical Sciences, Faculty of Medicine, "Transilvania" University of Braşov, Romania;

Purpose: The main purpose of the present paper is to analyze the rules for processing of special categories of personal data (genetic data, including biological samples, biometric and health data) in the light of the new General Data Protection Regulation (GDPR), thus contributing to overview the health status and the biomedical state of the data subject.

Background: Over the last two decades, debating the European Union's (EU) major legislation with regard to personal data and patients' rights became relevant for the scientific research. The paper assesses the basic legal provisions with regard to the genetic, biometric and data concerning health considered as "sensitive data", while safeguarding the ethical standards of the scientific research. Read More

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December 2018
9 Reads