2,358,155 results match your criteria Risk analysis : an official publication of the Society for Risk Analysis[Journal]


[Correlation between polymorphism of CYP19A1, GSTM1, GSTT1 and GSTP1 gene and endometriosis].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):515-519

Reproductive Medicine Center, the Affiliated Hospital of Inner Mongolia Medical University, Huhehot 010050, China.

To study the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis. Between October 2015 and October 2017, 262 endometriosis patients and 275 control subjects were recruited from the Affiliated Hospital of Inner Mongolia Medical University. Genotyping was conducted using polymerase chain reaction-coupled with restriction fragment length polymorphism and multiplex allele specific polymerase chain reaction. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.008DOI Listing
February 2019

Intensity-modulated radiation therapy dose prescription and reporting: Sum and substance of the International Commission on Radiation Units and Measurements Report 83 for veterinary medicine.

Vet Radiol Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Institutions' adherence to protocol, quality assurance, and radiation parameter reporting are key to adequately interpret and compare treatment outcomes in radiation oncology. In 2017, the editorial board for Veterinary Radiology & Ultrasound adapted author guidelines on "technical information for radiation therapy (RT)". These guidelines provide a framework to report the RT treatment process in manuscripts resulting from veterinary clinical trials. Read More

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http://dx.doi.org/10.1111/vru.12722DOI Listing
February 2019

[Alternative Psychoses and Forced Normalization after Seizure Control by Anticonvulsants with Special Consideration of the New Anticonvulsants].

Fortschr Neurol Psychiatr 2019 Feb 20. Epub 2019 Feb 20.

Zentrum für Psychiatrie Südwürttemberg, Klinik für Psychiatrie und Psychotherapie I, Universität Ulm.

In the case of alternative psychosis and forced normalization, the patient alternates between periods of clinically manifest seizures and normal behavior, and other periods of seizure freedom (or significant seizure reduction) accompanied by psychosis or behavioral disturbances. Unlike the clinically defined alternative psychosis, forced normalization is based on EEG findings. In clinical practice and in the literature, both terms are mostly used synonymously, and they also describe the same clinical pictures. Read More

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http://dx.doi.org/10.1055/a-0820-3345DOI Listing
February 2019

Acoustic Radiation Force Impulse Elastography and Ultrasonographic Findings of Achilles Tendon in Patients With and Without Diabetic Peripheral Neuropathy: A Cross-Sectional Study.

Exp Clin Endocrinol Diabetes 2019 Feb 20. Epub 2019 Feb 20.

Department of Endocrinology and Metabolism, Başkent University, Ankara, Turkey.

Aims: We aimed to evaluate the elastographic features of Achilles tendon with Acoustic Radiation Force Impulse in patients with and without diabetic neuropathy.

Methods: According to the presence of peripheral neuropathy, 45 patients with type 2 diabetes were divided into 2 subgroups. Those with peripheral neuropathy were defined as group I (22 patients) and those without peripheral neuropathy were defined as group II (23 patients). Read More

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http://dx.doi.org/10.1055/a-0840-3292DOI Listing
February 2019

Occult Urinary Incontinence Treatment: Systematic Review and Meta-analysis-Brazilian Guidelines.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):116-123. Epub 2019 Feb 20.

Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.

Objective:  To evaluate if performing anti-incontinence procedures during surgical anterior and/or apical prolapse correction in women with asymptomatic urinary incontinence (UI) may prevent stress urinary incontinence (SUI) postoperatively.

Methods:  We have performed a systematic review of articles published in the PubMed, Cochrane Library, and Lilacs databases until March 31, 2016. Two reviewers performed the data collection and analysis, independently. Read More

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http://dx.doi.org/10.1055/s-0038-1676842DOI Listing
February 2019

Effectiveness of Insulin Analogs Compared with Human Insulins in Pregnant Women with Diabetes Mellitus: Systematic Review and Meta-analysis.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):104-115. Epub 2019 Feb 20.

Universidade Federal de Alagoas, Maceió, AL, Brazil.

Diabetes during pregnancy has been linked to unfavorable maternal-fetal outcomes. Human insulins are the first drug of choice because of the proven safety in their use. However, there are still questions about the use of insulin analogs during pregnancy. Read More

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http://dx.doi.org/10.1055/s-0038-1676510DOI Listing
February 2019

The Use of Mobile Educational Tools to Improve Antimicrobial Prescription for the Treatment of Acute Pyelonephritis in Pregnancy: A Retrospective Cross-sectional Study.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):97-101. Epub 2019 Feb 20.

Graduate Program in Medicine and Health Sciences, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.

Objective:  To analyze the prescription of antimicrobial agents for pregnant women admitted into the obstetrics service who presented with acute pyelonephritis.

Methods:  Three cross-sectional studies were performed comparing the prescription of antimicrobials for pyelonephritis in pregnant women in the time periods evaluated (2010-2011: 99 patients evaluated; 2013: 116 patients evaluated; 2015: 107 patients evaluated), at the Hospital Fêmina, Porto Alegre, in the state of Rio Grande do Sul, Brazil. The analysis was performed before and after the promotion of an institutional protocol for the treatment of pyelonephritis during pregnancy, and on a third occasion after the introduction of a smartphone-based mobile educational tool. Read More

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http://dx.doi.org/10.1055/s-0039-1678590DOI Listing
February 2019
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[Health Expertise of Seasonal Influenza Vaccination among Midwife Trainees in North Rhine-Westphalia: Results of a Cross-Sectional Study].

Gesundheitswesen 2019 Feb 20. Epub 2019 Feb 20.

Institut für Hausarztmedizin, Medizinische Fakultät der Universität Bonn, Bonn.

Objective: For the first time, the level of knowledge and attitude towards vaccinations in general as well as seasonal influenza vaccination of midwife trainees in Germany was assessed.

Methods: The cross-sectional study was conducted between May and July 2017. The written standardized questionnaire was completed by all midwife-trainees in North Rhine-Westphalia. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0839-4810
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http://dx.doi.org/10.1055/a-0839-4810DOI Listing
February 2019
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A Nationwide Analysis of Preoperative Planning on Operative Times and Postoperative Complications in Total Knee Arthroplasty.

J Knee Surg 2019 Feb 20. Epub 2019 Feb 20.

Department of Orthopedic Surgery, Lenox Hill Hospital, Northwell Health, New York, New York.

Compared with nonelective total knee arthroplasties (TKAs), elective procedures have more time for preoperative planning, which allows for potentially improved patient optimization, risk factor modification, and patient education. The purpose of this study was to (1) determine nationwide trends in operative times and (2) evaluate associations between surgery type, elective or nonelective, with respect to (a) operative times, (b) length of stay (LOS), (c) discharge dispositions, (d) 30-day postoperative complications, (e) reoperations, and (f) readmissions. The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried for all primary TKAs performed between 2011 and 2016. Read More

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http://dx.doi.org/10.1055/s-0039-1677790DOI Listing
February 2019

["Crystal" and Pregnancy - The Preliminary Results of a Retrospective Study on the Course of Pregnancy and Delivery of Women Consuming Methamphetamine].

Z Geburtshilfe Neonatol 2019 Feb 20. Epub 2019 Feb 20.

Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus Dresden, Dresden.

Introduction: It can be observed that there is an increase in the methamphetamine (MA) consumption in Saxony (Federal Republic of Germany). There is so far no data available in German speaking countries about the risk of MA consumption in pregnancy or delivery.

Methods: The data from all pregnant women who were examined or delivered at the Clinic for Obstetrics and Gynaecology between 2010-2015 were retrospectively searched for MA consumption. Read More

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http://dx.doi.org/10.1055/a-0831-3642DOI Listing
February 2019

Sexual orientation identity in relation to unhealthy body mass index: individual participant data meta-analysis of 93 429 individuals from 12 UK health surveys.

J Public Health (Oxf) 2019 Feb 21. Epub 2019 Feb 21.

Public Health England, London, UK.

Background: Lesbian, gay and bisexual adults are more likely than heterosexual adults to experience worse health outcomes. Despite increasing public health interest in the importance of maintaining a healthy body weight, no study has considered sexual orientation identity (SOI) and unhealthy BMI categories among adults in the UK population.

Methods: Individual participant data meta-analysis using pooled data from population health surveys reporting on 93 429 adults with data on SOI, BMI and study covariates. Read More

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http://dx.doi.org/10.1093/pubmed/fdy224DOI Listing
February 2019

Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.

Exp Gerontol 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, Japan.

Systemic organ dysfunction is one of the important issues for the patients with Alzheimer's disease (AD) and their caregivers. Recent evidences suggest that periodontitis is a possible risk factor for progression of AD and lipopolysaccharide derived from Porphyromonas gingivalis (Pg-LPS) which is a major periodontopathic bacteria induces cognitive impairment in mice. However, the precise relationships between the brain exposure of Pg-LPS and systemic organ dysfunction in AD patients are still undetermined. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.007DOI Listing
February 2019

Unexpected term NICU admissions: a marker of obstetrical care quality?

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard University, Boston, MA.

Background: Unexpected admissions of term neonates to the neonatal intensive care unit (NICU) and unexpected postnatal complications have been proposed as neonatal-focused quality metrics for intrapartum care. Previous studies have noted significant variation in overall hospital NICU admission rates; however, little is known about the influence of obstetric practices on these rates or whether variation among unanticipated admissions in low risk, term neonates can be attributed to systemic hospital practices.

Objective: To examine the relative effects of patient characteristics and intrapartum events on unexpected NICU admissions, and to quantify the between-hospital variation in NICU admission rates among this group of neonates. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.001DOI Listing
February 2019

Maternal Outcomes by Race during Postpartum Readmissions.

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY. Electronic address:

Background: Maternal race may be an important risk factor for postpartum readmissions and associated adverse outcomes.

Objective: To determine the association of race with serious complications during postpartum readmissions.

Study Design: This repeated cross sectional analysis utilized the National (Nationwide) Inpatient Sample from the Healthcare Cost and Utilization Project from 2012 to 2014. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.016DOI Listing
February 2019

Delayed Clamping Versus Milking of Umbilical Cord in Preterm Infants: A Randomized Controlled Trial.

Am J Obstet Gynecol 2019 Feb 5. Epub 2019 Feb 5.

Department of Obstetrics and Gynecology, TriHealth, Cincinnati, OH.

Background: It has been established that delayed umbilical cord clamping in preterm infants results in improvement in neonatal anemia, need for transfusion, incidence of necrotizing enterocolitis, and intraventricular hemorrhage by increasing neonatal circulating blood volume. However, the effects of umbilical cord milking as an alternative to delayed clamping in preterm infants are unclear.

Objective: The primary objective of this study was to compare the effect of delayed clamping versus milking of the umbilical cord on the initial hematocrit concentration in preterm births (23-34 weeks). Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.234DOI Listing
February 2019

Obesity and Laboratory Aspirin Resistance in High Risk Pregnant Women Treated with Low Dose Aspirin.

Am J Obstet Gynecol 2019 Jan 29. Epub 2019 Jan 29.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH.

Background: Low dose aspirin (LDA) is used for preeclampsia (PE) prevention in high risk women, but the precise mechanism and optimal dose is unknown. Evidence suggests that an imbalance in prostacyclin and thromboxane A (TXA) plays a key role in the pathogenesis of PE. Aspirin has a dose-dependent effect blocking production of TXA, a potent stimulator of platelet aggregation and promoter of vasoconstriction. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.222DOI Listing
January 2019

Associations between aerobic and muscle-strengthening exercise with depressive symptom severity among 17,839 U.S. adults.

Prev Med 2019 Feb 17. Epub 2019 Feb 17.

Physically Active Lifestyles Research Group (USQ PALs), Institute for Resilient Regions, University of Southern Queensland, Springfield, Queensland, Australia.

For the prevention and management of chronic diseases, global physical activity guidelines state that an adult should engage in regular moderate-to-vigorous aerobic physical activity (MVPA; e.g. walking, cycling, running) and muscle-strengthening exercise (MSE; e. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.022DOI Listing
February 2019

Using A Developmental Ecology Framework to Align Fear Neurobiology Across Species.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, Columbia University, New York, NY 10027, USA; email: , , ,

Children's development is largely dependent on caregiving; when caregiving is disrupted, children are at increased risk for numerous poor outcomes, in particular psychopathology. Therefore, determining how caregivers regulate children's affective neurobiology is essential for understanding psychopathology etiology and prevention. Much of the research on affective functioning uses fear learning to map maturation trajectories, with both rodent and human studies contributing knowledge. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095727DOI Listing
February 2019

Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; email:

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-clinpsy-05
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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095754DOI Listing
February 2019
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Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Geriatric Research, Education, and Clinical Center, Tennessee Valley Veterans Affairs Medical Center, Nashville, Tennessee 37212, USA.

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095557DOI Listing
February 2019
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High-resolution Regulatory Maps Connect Vascular Risk Variants to Disease Related Pathways.

Circ Genom Precis Med 2019 Feb 20. Epub 2019 Feb 20.

Science for Life Laboratory, KTH - Royal Institute of Technology, Solna, Sweden.

Background: Genetic variant landscape of coronary artery disease (CAD) is dominated by non-coding variants among which many occur within putative enhancers regulating the expression levels of relevant genes. It is crucial to assign the genetic variants to their correct genes both to gain insights into perturbed functions and better assess the risk of disease.

Methods: In this study, we generated high-resolution genomic interaction maps (~750 bases) in aortic endothelial, smooth muscle cells and THP-1 macrophages stimulated with lipopolysaccharide using Hi-C coupled with sequence capture targeting 25,429 features including variants associated with CAD. Read More

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http://dx.doi.org/10.1161/CIRCGEN.118.002353DOI Listing
February 2019

Risk Factors for Dental Restoration Survival: A Practice-Based Study.

J Dent Res 2019 Feb 20:22034519827566. Epub 2019 Feb 20.

1 Department of Dentistry, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.

To improve patient dental care, it is necessary to identify possible risk factors for the failing of restorations. This practice-based cohort study investigated the performance and influence of possible risk factors at the level of the practice, patient, tooth, and restoration on survival of direct class II restorations. Electronic patient files from 11 Dutch general practices were collected, and 31,472 restorations placed between January 2015 and October 2017 were analyzed. Read More

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http://dx.doi.org/10.1177/0022034519827566DOI Listing
February 2019

Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.

N Engl J Med 2019 02;380(8):720-728

From the Department of Hematology and Medical Oncology, Taussig Cancer Institute and Case Comprehensive Cancer Center, Cleveland Clinic, Cleveland (A.A.K.); the Department of Medicine, Memorial Sloan Kettering Cancer Center (G.A.S., E.M.O.), and Weill Cornell Medical College (G.A.S., E.M.O.), New York; the Thrombosis Research Institute and University College London, London (A.K.K.); University of Texas M.D. Anderson Cancer Center, Houston (S.V.-R.), and U.S. Oncology Research-Texas Oncology, Tyler (H.A.Y.) - both in Texas; the Department of Medicine, Charité Universitätsmedizin Berlin, Berlin (H.R.); the Division of Hematology-Oncology, University of California Davis School of Medicine, Sacramento (T.W.), and the Keck School of Medicine, University of Southern California, Los Angeles (H.A.L.); the Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore (M.B.S.); the University of Washington School of Medicine (D.A.G., N.M.K., G.H.L.), Advanced Cancer Research Group (N.M.K.), and Fred Hutchinson Cancer Research Center (G.H.L.), Seattle; Penn State Cancer Institute, Milton S. Hershey Medical Center, Hershey, PA (C.P.B.); the Department of Cancer Pharmacology, Levine Cancer Institute, Atrium Health, Charlotte, NC (J.N.P.); Janssen Scientific Affairs, Titusville (P.W., P.B., S.K.), and Janssen Research and Development, Raritan (U.V.) - both in New Jersey; the Department of Medicine, McMaster University, Hamilton, ON, Canada (J.E.); the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (R.M.); and the Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston (K.A.B.).

Background: Ambulatory patients receiving systemic cancer therapy are at varying risk for venous thromboembolism. However, the benefit of thromboprophylaxis in these patients is uncertain.

Methods: In this double-blind, randomized trial involving high-risk ambulatory patients with cancer (Khorana score of ≥2, on a scale from 0 to 6, with higher scores indicating a higher risk of venous thromboembolism), we randomly assigned patients without deep-vein thrombosis at screening to receive rivaroxaban (at a dose of 10 mg) or placebo daily for up to 180 days, with screening every 8 weeks. Read More

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http://dx.doi.org/10.1056/NEJMoa1814630DOI Listing
February 2019

When to refer: validating the Evidence-based Acute Otitis Externa Referral Score (EARS). Our experience of 287 cases of otitis externa in Primary Care.

Clin Otolaryngol 2019 Feb 20. Epub 2019 Feb 20.

Mersey ENT Research Collaborative (MERC).

Recognising individuals at risk of developing complications from acute otitis externa would assist General Practitioners in their decision to manage cases in Primary Care or seek referral to a specialist service. The Evidence-based Acute Otitis Externa Referral Score (EARS) is a novel risk-stratification score aimed at recognising patients at risk of developing complications of acute otitis externa. The EAR Score had a sensitivity of 100% and specificity of 90%. Read More

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http://dx.doi.org/10.1111/coa.13320DOI Listing
February 2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Objective: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

Design: Individual participant data meta-analysis of 39 cohorts.

Setting: Europe, North America and Oceania. Read More

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http://dx.doi.org/10.1111/1471-0528.15661DOI Listing
February 2019

Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population based study.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

Division of Epidemiology & Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, NG5 1PB, Nottingham, UK.

Objectives: To assess how nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG) are managed and treated across primary and secondary care.

Design: Population-based pregnancy cohort.

Setting: Medical records (CPRD-GOLD) from England. Read More

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http://dx.doi.org/10.1111/1471-0528.15662DOI Listing
February 2019

Evaluation of pulmonary toxicity of benzalkonium chloride and triethylene glycol mixtures using in vitro and in vivo systems.

Environ Toxicol 2019 Feb 20. Epub 2019 Feb 20.

Risk Assessment Division, Environmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea.

Benzalkonium chloride (BAC) is a widely used disinfectant/preservative, and respiratory exposure to this compound has been reported to be highly toxic. Spray-form household products have been known to contain BAC together with triethylene glycol (TEG) in their solutions. The purpose of this study was to estimate the toxicity of BAC and TEG mixtures to pulmonary organs using in vitro and in vivo experiments. Read More

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http://dx.doi.org/10.1002/tox.22722DOI Listing
February 2019

Birth weight and risk of type 2 diabetes mellitus: a dose-response meta-analysis of cohort studies.

Diabetes Metab Res Rev 2019 Feb 20:e3144. Epub 2019 Feb 20.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Background: The association between birth weight and type 2 diabetes mellitus has been debated for several decades, and the dose-response relationship has not been reported. The objective of this systematic review and meta-analysis was to quantitatively clarify the association between birth weight and risk of type 2 diabetes mellitus based on cohort studies.

Methods: We searched PubMed, Web of Science and Embase Databases for cohort study articles on the association between birth weight and risk of type 2 diabetes mellitus published up to March 1, 2018. Read More

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http://dx.doi.org/10.1002/dmrr.3144DOI Listing
February 2019

Caffeinated and decaffeinated coffee consumption and risk of all-cause mortality: a dose-response meta-analysis of cohort studies.

J Hum Nutr Diet 2019 Feb 20. Epub 2019 Feb 20.

Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.

Background: Previous meta-analysis showed an inverse association between coffee consumption and all-cause mortality. However, the relationship between caffeinated and decaffeinated coffee consumption and all-cause mortality is inconsistent. We aimed to identify and review the published evidence updating the association between coffee consumption and all-cause mortality and, furthermore, to investigate the association of caffeinated and decaffeinated coffee consumption and all-cause mortality. Read More

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http://dx.doi.org/10.1111/jhn.12633DOI Listing
February 2019

Blastemal Predominant Type Wilms Tumors in Japan: Japan Children's Cancer Group.

Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.

Background: Persistence of blastemal components after chemotherapy is a marker of poor outcome in Wilms tumor. Recent reports from local Japanese areas have described prechemotherapy blastemal predominant type Wilms tumor to be also a risk factor for relapse. However, significance of blastemal predominant WT remains to be evaluated in a larger study. Read More

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http://dx.doi.org/10.1111/ped.13811DOI Listing
February 2019

Hematopoietic stem cell transplantation in children with sickle cell anemia: The parents' experience.

Pediatr Transplant 2019 Feb 20:e13376. Epub 2019 Feb 20.

Department of Psychopathology, Avicenne Hospital, Paris XIII University & Assistance Publique-Hôpitaux de Paris, Bobigny, France.

Genoidentical HSCT is currently the only curative treatment for SCA, preventing further vascular complications in high-risk children. Studies on the psychological implications of HSCT for recipient, sibling donor, and the rest of the family have been limited in SCA. This study enrolled ten families and used semi-structured interviews to explore the parents' experience at three time points: first before transplantation, then 3 months later, and 1 year later. Read More

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http://dx.doi.org/10.1111/petr.13376DOI Listing
February 2019

Gastrostomy tubes appear to be safe following pediatric orthotopic heart transplant.

Pediatr Transplant 2019 Feb 20:e13374. Epub 2019 Feb 20.

Division of Pediatric Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.

Background: Gastrostomy tube (GT) placement is a common pediatric surgical procedure typically indicated for oral aversion. This may develop in patients with congenital heart disease (CHD) who require an orthotopic heart transplant (OHT). The safety profile of GT placement in OHT patients who are immunosuppressed is unknown. Read More

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http://doi.wiley.com/10.1111/petr.13374
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http://dx.doi.org/10.1111/petr.13374DOI Listing
February 2019
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Gender differences in lifestyle and risk factors of metabolic syndrome: Do women have better health habits than men?

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Nursing, Chang Gung University of Science and Technology, No.261, Wenhua 1st Rd., Guishan Dist. 33303, Taoyuan City, Taiwan.

Aims And Objectives: The purpose of this paper was to examine the gender-specific lifestyles of adults with metabolic syndrome in the Taiwanese community.

Background: Many studies show different prevalence of metabolic syndrome in males and females, however few studies have investigated gender-specific lifestyle risk factors, which are important for effectively reducing prevalence.

Design: A cross-sectional study design was used. Read More

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http://dx.doi.org/10.1111/jocn.14824DOI Listing
February 2019

The forgotten mothers of extremely preterm babies: a qualitative study.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

University of Hertfordshire.

Aims: To explore the experiences of mothers of extremely premature babies during their Neonatal Intensive Care Unit stay and transition home.

Background: Mothers of extremely preterm infants (28-weeks-or-less gestation) experience a continuum of regular and repeated stressful and traumatic events; during the perinatal period, while the Neonatal Intensive Care Unit, and during transition home.

Method: An interpretive description method guided this study. Read More

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http://dx.doi.org/10.1111/jocn.14820DOI Listing
February 2019

Adherence assessment practices in haemodialysis settings: a qualitative exploration of nurses and pharmacists' perspectives.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

School of Healthcare, University of Leeds, Leeds, United Kingdom.

Aims And Objectives: To explore clinician assessment of patient adherence, and identify strategies to improve adherence assessment practices in haemodialysis settings.

Background: Patients with chronic kidney disease undergoing haemodialysis are typically prescribed complex regimens; as such, they are at high risk of medication nonadherence. Current clinical practices focus on prescribing medications, however, little attention is paid to measuring and ensuring patient adherence to their prescribed treatments. Read More

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http://dx.doi.org/10.1111/jocn.14821DOI Listing
February 2019

Undiagnosed delirium is frequent and difficult to predict: Results from a prevalence survey of a tertiary hospital.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine and Aged Care, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.

Aims And Objectives: To study the prevalence and determinants of undiagnosed delirium in a tertiary hospital.

Background: Delirium is a common inpatient condition. It is frequently undiagnosed in a variety of settings, but determinants of undiagnosed delirium are largely unknown, and the frequency of undiagnosed delirium across all inpatient units is uncertain. Read More

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http://doi.wiley.com/10.1111/jocn.14833
Publisher Site
http://dx.doi.org/10.1111/jocn.14833DOI Listing
February 2019
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Central venous line-related thromboembolism is common in children with non-high risk acute lymphoblastic leukaemia.

Acta Paediatr 2019 Feb 20. Epub 2019 Feb 20.

Department of Paediatric Haematology and Oncology, Oslo University Hospital, Norway.

Children with acute lymphoblastic leukaemia face increased risks of thromboembolism, and major risk factors for this serious treatment-related toxicity are central venous lines, asparaginase and steroids. Central venous lines have become standard care in paediatric oncology, facilitating therapy and improving patients' quality of life. However, up to half of the children with acute lymphoblastic leukaemia will develop asymptomatic central venous line-related thromboembolism. Read More

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http://dx.doi.org/10.1111/apa.14757DOI Listing
February 2019

Serum Mac-2-binding protein glycosylation isomer and risk of hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients.

J Gastroenterol Hepatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine, Queen Mary Hospital, Hong Kong.

Background And Aim: Hepatocellular carcinoma (HCC) can still develop in chronic hepatitis B (CHB) patients receiving antiviral treatment. Serum Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel marker for liver fibrosis. We investigated its role on incidence of HCC in entecavir (ETV)-treated CHB patients. Read More

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http://dx.doi.org/10.1111/jgh.14637DOI Listing
February 2019

Smoking and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study.

Ann Neurol 2019 Feb 20. Epub 2019 Feb 20.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

In this study, we examined the potential causal effect of smoking on amyotrophic lateral sclerosis using the Project MinE data involving 12,577 patients with amyotrophic lateral sclerosis and 23,475 controls in a Mendelian randomization (MR) framework. The MR approach has the potential to investigate causal relationship between a risk factor and a disease, avoiding confounding and information bias that often present in conventional epidemiological studies. We found that smokers had a higher risk of amyotrophic lateral sclerosis compared to never smokers. Read More

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http://dx.doi.org/10.1002/ana.25443DOI Listing
February 2019

Effect of a mHealth program on coronary heart disease prevention among working population in Singapore: a single group pretest-posttest design.

J Adv Nurs 2019 Feb 20. Epub 2019 Feb 20.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Aim: To develop and examine the effectiveness of a 4-week mHealth program using the smartphone app Care4Heart on awareness, knowledge, perceived stress and a heart-related lifestyle among working population in Singapore.

Design: A quasi-experimental single group pre- and repeated post-test design.

Methods: A total of 160 nonhealth-related working adults were recruited from February 2016 - April 2016. Read More

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http://dx.doi.org/10.1111/jan.13980DOI Listing
February 2019

Concordance for Parkinson's Disease in Twins: a 20-Year Update.

Ann Neurol 2019 Feb 20. Epub 2019 Feb 20.

University of California-San Francisco, Department of Neurology; San Francisco Veterans Affairs Health Care System, San Francisco, CA.

During the 1990s we estimated the genetic contribution to Parkinson's disease risk in a large population-based twin registry. Because many unaffected twins were still alive, prior concordance estimates were based on incomplete information. 95% of twins are now deceased. Read More

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http://dx.doi.org/10.1002/ana.25441DOI Listing
February 2019

Localized synovial sarcoma: A single institutional study of 191 patients with a minimum follow-up of 5 years for survivors.

J Surg Oncol 2019 Feb 20. Epub 2019 Feb 20.

Oncology Service, Royal Orthopaedic Hospital, Birmingham, United Kingdom.

Purpose: Factors affecting long-term outcomes of synovial sarcoma (SS) remain unknown. Here, we aimed to investigate the long-term oncological outcomes and prognostic factors in a large group of patients with surgically-treated localized SS.

Patients And Methods: Between 1980 and 2011, 191 patients (94 males and 97 females) were treated at a single hospital with a minimum follow-up of 5 years for survivors. Read More

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http://dx.doi.org/10.1002/jso.25417DOI Listing
February 2019

A nomogram to predict osteoradionecrosis in oral cancer after marginal mandibulectomy and radiotherapy.

Laryngoscope 2019 Feb 20. Epub 2019 Feb 20.

Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Taiwan.

Objective: There is no useful tool to clinically predict the occurrence of osteoradionecrosis (ORN) of the mandible quantitatively. The aim was to investigate the risk factors, including different modalities of radiotherapy, for developing mandibular ORN in patients undergoing marginal mandibulectomy and postoperative radiotherapy.

Methods: Between January 2006 and December 2012, 167 subjects who underwent marginal mandibulectomy and postoperative radiotherapy with different modalities were enrolled. Read More

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http://dx.doi.org/10.1002/lary.27870DOI Listing
February 2019

Middle cerebral artery peak systolic velocity in perinatal cytomegalovirus infection.

J Clin Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, Tennessee.

A middle cerebral artery peak systolic velocity value (MCA-PSV) persistently greater than 1.5 times the median of the normal population is utilized to detect moderate and severe anemia in fetuses at risk. Cytomegalovirus (CMV) is the most common perinatal infection and can cause fetal anemia. Read More

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http://doi.wiley.com/10.1002/jcu.22715
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http://dx.doi.org/10.1002/jcu.22715DOI Listing
February 2019
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Examining the contribution of surrounding intact skin during cutaneous healing.

J Anat 2019 Feb 20. Epub 2019 Feb 20.

Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.

Severe cutaneous wounds expose the body to the external environment, which may lead to impairments in bodily functions and increased risk of infection. There is a need to develop skin substitutes which could effectively promote complete skin regeneration following an injury. Murine models are used to test such skin substitutes, but their healing involves contraction of the dermis not found in human wounds. Read More

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http://doi.wiley.com/10.1111/joa.12941
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http://dx.doi.org/10.1111/joa.12941DOI Listing
February 2019
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Association of vaspin rs2236242 gene variants with type 2 diabetes and obesity in a Chinese population: A prospective, single-center study.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.

Aim: Vaspin is an adipokine separated from visceral fat tissues of obese diabetic rats. This study was to investigate the association between vaspin rs2236242 gene polymorphism and type 2 diabetes mellitus (T2DM) or obesity in a Chinese population.

Materials And Methods: T2DM patients and nondiabetic controls were recruited from Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University (Shanghai, China) from May 1, 2015 to June 30, 2017. Read More

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http://dx.doi.org/10.1002/jcp.28267DOI Listing
February 2019

Association of cardiovascular autonomic dysfunction with peripheral arterial stiffness in patients with type 1 diabetes.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Context: Cardiovascular autonomic (CAN) neuropathy appears to contribute to peripheral arterial stiffness (AS) in type 1 diabetes. If CAN in patients with AS is associated to concomitant asymptomatic atherosclerotic disease (aPAD) remains unclear.

Objective: To assess the risk of CAN in patients with type 1 diabetes and AS and its potential association to atherosclerosis. Read More

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http://dx.doi.org/10.1210/jc.2018-02729DOI Listing
February 2019

Epigenetic age acceleration in adolescence associates with BMI, inflammation and risk score for middle age cardiovascular disease.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Curtin/UWA Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia.

Background: 'Accelerated ageing', assessed by adult DNA methylation predicts cardiovascular disease (CVD). Adolescent accelerated aging might predict CVD earlier. We investigated whether epigenetic age acceleration (assessed age 17-years) associated with adiposity/CVD-risk measured (ages 17, 20, 22-years), and projected CVD by middle-age. Read More

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http://dx.doi.org/10.1210/jc.2018-02076DOI Listing
February 2019

A Simplified Approach to Reducing Cardiovascular Risk.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

University of New Mexico Health Sciences Center, Department of Internal Medicine, Division of Endocrinology.

Clinical Issue: Cardiovascular disease remains the number one cause of morbidity and mortality in the United States despite major advances in our understanding of its pathogenesis and prevention. One reason for this continued epidemic is the poor adherence to treatment guidelines by caregivers and the lack of understanding by patients relative to its reversibility with treatment. Current guidelines are complex and often contradictory as there are at least 21 organizations publishing guidelines. Read More

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http://dx.doi.org/10.1210/jc.2018-02509DOI Listing
February 2019
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