2,388,440 results match your criteria Risk analysis : an official publication of the Society for Risk Analysis[Journal]


Detecting Early Pancreatic Cancer: Current Problems and Future Prospects.

Gut Liver 2019 Apr 23. Epub 2019 Apr 23.

Divisions of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. Read More

View Article

Download full-text PDF

Source
http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
Publisher Site
http://dx.doi.org/10.5009/gnl18491DOI Listing
April 2019
1 Read

Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study.

Hum Mol Genet 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Microbiology and Immunology, University of California, Davis, CA, USA.

DNA methylation acts at the interface of genetic and environmental factors relevant for autism spectrum disorder (ASD). Placenta, normally discarded at birth, is a potentially rich source of DNA methylation patterns predictive of ASD in the child. Here, we performed whole methylome analyses of placentas from a prospective study MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) of high-risk pregnancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddz084DOI Listing

Long-Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture Prevention: A Systematic Review.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of Minnesota and Minneapolis VA Health Care System, Minneapolis, Minnesota (H.A.F., R.M., K.E.E., K.U., B.C.T., T.J.W.).

Background: Optimal long-term osteoporosis drug treatment (ODT) is uncertain.

Purpose: To summarize the effects of long-term ODT and ODT discontinuation and holidays.

Data Sources: Electronic bibliographic databases (January 1995 to October 2018) and systematic review bibliographies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7326/M19-0533DOI Listing

Maternal Glycemic Control in Type 1 Diabetes and the Risk for Preterm Birth: A Population-Based Cohort Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Karolinska Institutet, Stockholm, Sweden, and Statens Serum Institut, Copenhagen, Denmark (B.P.).

Background: Maternal type 1 diabetes (T1D) has been linked to preterm birth and other adverse pregnancy outcomes. How these risks vary with glycated hemoglobin (or hemoglobin A1c [HbA1c]) levels is unclear.

Objective: To examine preterm birth risk according to periconceptional HbA1c levels in women with T1D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7326/M18-1974DOI Listing

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Aging (Albany NY) 2019 Apr;11(7):2045-2070

See ACKNOWLEDGMENTS AND FUNDING.

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.101900DOI Listing

Exploring the Roles of Central and Peripheral Nervous System Function in Gait Stability: Preliminary Insights from Cancer Survivors.

Gait Posture 2019 Apr 6;71:62-68. Epub 2019 Apr 6.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA; School of Health & Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.

Background: Impairments in central and/or peripheral nervous systems are known to be associated with altered gait; however, the interplay between cognitive function, peripheral sensation, and orbital gait stability remains largely unclear. Elucidating these relationships is expected to provide a clearer understanding of potential fall risk factors across various populations and targets for novel interventions. Many patients diagnosed with cancer are treated with chemotherapy agents known to be neurotoxic to the central and/or peripheral nervous systems that can contribute to movement deficiencies, making this population a novel model to investigate these relationships. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09666362183163
Publisher Site
http://dx.doi.org/10.1016/j.gaitpost.2019.04.002DOI Listing
April 2019
1 Read

Multitarget PPARγ agonists as innovative modulators of the metabolic syndrome.

Eur J Med Chem 2019 Apr 13;173:261-273. Epub 2019 Apr 13.

Department of Pharmacy, University of Chieti "G. d.Annunzio", Via Dei Vestini, 31, 66100, Chieti, Italy.

A multitarget pharmacologic approach could be advantageous for the therapy of metabolic multiple diseases, such as the metabolic syndrome, which is characterized by metabolic abnormalities associated with diabetes, obesity, hypertension, and increased cardiovascular risk. PPAR receptors play a critical role in metabolic disorders, affecting glucose and lipid metabolism. Drugs simultaneously targeting PPAR and other validated metabolic targets, represent a promising multitarget approach to combine antihyperglycemic, antihyperlipidemic, and antihypertensive effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.04.030DOI Listing

"Closed-Incision Negative-Pressure Therapy Efficacy in Abdominal Wall Reconstruction in High-Risk Patients: A Meta-Analysis".

J Surg Res 2019 Apr 19;241:63-71. Epub 2019 Apr 19.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Obesity is a known risk factor for surgical complications. Closed-incision negative-pressure therapy (ciNPT) has been used anecdotally in high-risk patients to prevent wound complications and infection. This meta-analysis aims to evaluate the efficacy of ciNPT in reducing the incidence of wound complications and infection in abdominal wall reconstruction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2019.03.033DOI Listing

Opportunities of electrokinetics for the remediation of mining sites in Biga peninsula, Turkey.

Chemosphere 2019 Apr 15;227:606-613. Epub 2019 Apr 15.

Department of Geological Engineering, Canakkale Onsekiz Mart University, Canakkale, Turkey.

This study investigated the geological conditions of Biga Peninsula. There are metamorphic rocks, ophiolitic melange, plutonic rocks, subvolcanics, volcanic rocks and volcanoclastics along with marine and terrestrial sediments in the region. This variety of rocks and the associated minerals resulted in many interesting metallic ores and coal for commercial exploitation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.04.059DOI Listing

Incidence and risk factors of post-cranioplasty seizures.

Seizure 2019 Apr 13;69:115. Epub 2019 Apr 13.

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2019.04.009DOI Listing

Arterial and venous complications after fertility treatment: A French nationwide cohort study.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 11;237:57-63. Epub 2019 Mar 11.

The French Public Health Agency, Non-Communicable Disease and Trauma Division, Saint-Maurice, France.

Objectives: To determine whether the risk of thromboembolic complications is higher in women following unsuccessful fertility treatment (FT) and in pregnant women following successful FT, and whether the risk differs according to FT type.

Study Design: This is an observational prospective cohort study. All French women aged 18-45 years who received FT between 2013 and 2015 were selected from the French health insurance claim database which registers healthcare consumption for the entire French population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2019.02.034DOI Listing
March 2019
2 Reads

The risk of malignancy in uterine polyps: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:48-56. Epub 2019 Apr 15.

Department of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli studi di Milano, Milan, Italy. Electronic address:

Background: Endometrial polyps are a common condition. The risk of malignancy has often led to an overtreatment with high health care costs and huge psychological distress.

Objective: We conducted a systematic review and a meta-analysis in order to estimate the prevalence of premalignant and malignant lesions in women undergoing hysteroscopic polypectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2019.04.009DOI Listing

An AMH-based FSH dosing algorithm for OHSS risk reduction in first cycle antagonist protocol for IVF/ICSI.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 12;237:42-47. Epub 2019 Apr 12.

The Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

The study assessed the impact of an AMH algorithm for FSH dosing in 589 patients to maintain pregnancy rates while minimizing OHSS rates in 1st antagonist cycles for IVF. Patients with low AMH < 12 pmol/L (n = 203) had maximal stimulation with corifollitropin, patients with AMH 12-32 pmol/L (n = 256) had standard stimulation with 150 IU/day of rFSH and patients with AMH > 32 pmol/L (n = 130) had minimal stimulation with 112 IU/day of HP-hMG. The proportion of patients with targeted (5-14) number of oocytes at retrieval was: Low AMH 42%, intermediate AMH 76% and high AMH 67% (p < 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2019.02.001DOI Listing

The association between metformin therapy and risk of gynecological cancer in patients: Two meta-analyses.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:33-41. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Recently, metformin, first-line drug for type 2 diabetes, has been reported to treat some gynecological tumors. However, these epidemiological studies have never been formally summarized. Considering a single study may lack the power to provide reliable conclusion, we performed two meta-analyses with different indicators to assess metformin's role in reducing the risk of gynecological cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2019.03.029DOI Listing

Protein corona variation in nanoparticles revisited: A dynamic grouping strategy.

Colloids Surf B Biointerfaces 2019 Apr 3;179:505-516. Epub 2019 Apr 3.

Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran; Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Bio-nano interface investigation models are mainly based on the type of proteins present on corona, bio-nano interaction responses and the evaluation of final outcomes. Due to the extensive diversity in correlative models for investigation of nanoparticles biological responses, a comprehensive model considering different aspects of bio-nano interface from nanoparticles properties to protein corona fingerprints appeared to be essential and cannot be ignored. In order to minimize divergence in studies in the era of bio-nano interface and protein corona with following therapeutic implications, a useful investigation model on the basis of RADAR concept is suggested. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2019.04.003DOI Listing

Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses.

Phytomedicine 2018 Nov 28;59:152774. Epub 2018 Nov 28.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address:

Background: Diabetes mellitus is a well-known risk factor for the development of heart failure. Inflammation and oxidative stress play a key role in the development of diabetic cardiomyopathy (DCM), and this nexus represents an attractive target to combat this disease. Naturally occurring flavonoid luteolin exhibits both anti-inflammatory and antioxidant activities in various systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2018.11.034DOI Listing
November 2018

Intelligence and memory outcomes within 10 years of childhood convulsive status epilepticus.

Epilepsy Behav 2019 Apr 18;95:18-25. Epub 2019 Apr 18.

Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh, UK.

Long-term intelligence and memory outcomes of children post convulsive status epilepticus (CSE) have not been systematically investigated despite evidence of short-term impairments in CSE. The present study aimed to describe intelligence and memory outcomes in children within 10 years of CSE and identify potential risk factors for adverse outcomes. In this cohort study, children originally identified by the population-based North London Convulsive Status Epilepticus in Childhood Surveillance Study (NLSTEPSS) were prospectively recruited between July 2009 and February 2013 and invited for neuropsychological assessments and magnetic resonance imaging (MRI) scans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.03.039DOI Listing

The value of manure - Manure as co-product in life cycle assessment.

J Environ Manage 2019 Apr 19;241:293-304. Epub 2019 Apr 19.

Innovation Center for U.S. Dairy, USA.

Livestock production is important for food security, nutrition, and landscape maintenance, but it is associated with several environmental impacts. To assess the risk and benefits arising from livestock production, transparent and robust indicators are required, such as those offered by life cycle assessment. A central question in such approaches is how environmental burden is allocated to livestock products and to manure that is re-used for agricultural production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.03.059DOI Listing

Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 515.33 TERT-CLPTM1L Region.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address:

Introduction: Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
Publisher Site
http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
April 2019
1 Read

Abdominal Pain in Children Develops With Age and Increases With Psychosocial Factors.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Div of Pediatrics, Dept of Clinical and Experimental Medicine, Linköping university SE 58185 Linköping, Sweden; Crown Princess Victoria Children´s Hospital, Region Östergötland, Linköping, Sweden.

Background & Aims: Functional gastrointestinal disorders are highly prevalent, cause significant suffering, and are costly to society. Pain is a central feature of 2 of the most common functional gastrointestinal disorders-irritable bowel syndrome and functional dyspepsia. Although these disorders have been well studied in adults, their etiology is poorly understood. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
Publisher Site
http://dx.doi.org/10.1016/j.cgh.2019.04.036DOI Listing
April 2019
1 Read

Risk Factors for Severe Liver Disease in Patients With Type 2 Diabetes.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Upper Gastrointestinal Diseases, Division of Hepatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Background & Aims: Type 2 diabetes is a risk factor for development of cirrhosis and hepatocellular carcinoma. However, risk factor that identify persons with the highest risk for these outcomes are missing from unselected, population-based cohorts.

Methods: The National Diabetes Register contains data on about 90% of persons in Sweden with type 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2019.04.038DOI Listing

Lower hemoglobin levels are associated with acute seizures in patients with ruptured cerebral aneurysms.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China. Electronic address:

Objective: We test the hypothesis that low hemoglobin levels are associated with acute seizures following aneurysmal subarachnoid hemorrhage (aSAH).

Methods: Patients with ruptured intracranial aneurysms were enrolled in the observational cohort study that prospectively collected age, sex, symptom onset, history of diabetes and hypertension, history of coronary artery disease, temperature, Hunt-Hess grade, Fisher grade, aneurysm location, hemoglobin, hematocrit, serum potassium, sodium, calcium, phosphorus, iron, and modified Rankin Scale (mRS). Acute seizures were determined as seizures within one week following aSAH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.04.115DOI Listing

Effect Of Fetal Posterior Circulation On Efficacy Of Flow Diversion For Treatment Of Posterior Communicating Artery Aneurysms: A Multi-Instutional Study.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Background: Flow diversion (FD) has emerged as an effective treatment modality for aneurysms of the posterior communicating artery (PCOM). Whether or not a fetal posterior circulation (FPC) affects PCOM aneurysm occlusion rates after FD remains undetermined.

Methods: We performed a retrospective cohort study in which treatment outcomes for FD of PCOM aneurysms from multiple institutions were reviewed. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18788750193110
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2019.04.112DOI Listing
April 2019
1 Read

Risk of deterioration of geriatric traumatic brain injury in patients treated with antithrombotic drugs.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

The Japan Neurotrauma Data Bank Committee, The Japan Society of Neurotraumatology, Tokyo, Japan.

Objective: Developed countries have rapidly aging populations, and use of antithrombotic drugs is increasing. We investigated the effects of antithrombotic drugs and reversal of these drugs in geriatric traumatic brain injury (TBI) patients.

Methods: Age, gender, mechanism of injury, Glasgow Coma Scale on admission, head CT findings, antithrombotic therapy, acute exacerbation, and outcomes at discharge were examined in 711 patients with geriatric TBI complicated with traumatic intracranial hemorrhage using data from the Japan Neurotrauma Data Bank Project 2015 (JNTDB P2015). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.04.108DOI Listing

Changes in Healthcare Delivery Following Spinal Fracture in Medicare Accountable Care Organizations.

Spine J 2019 Apr 19. Epub 2019 Apr 19.

Center for Surgery and Public Health, Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115. Electronic address:

Background Context: Accountable Care Organizations (ACOs) were designed to reduce healthcare costs while simultaneously improving quality. Given that the success of ACOs is predicated on controlling costs, concerns have been expressed that patients could be adversely affected through restricted access to surgery, including in the context of spine fracture care.

Purpose: Evaluate the impact of Medicare ACO formation on the utilization of surgery and outcomes following spinal fractures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.spinee.2019.04.014DOI Listing

Mechanisms behind the atherothrombotic effects of acrolein, a review.

Food Chem Toxicol 2019 Apr 19. Epub 2019 Apr 19.

Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The majority of cardiovascular complications are secondary to atherosclerosis. Extensive evidence has showed that environmental pollutants such as cigarette smoke and automobile exhaust increase the risk of developing atherosclerosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2019.04.034DOI Listing

Reappraisal of probiotics' safety in human.

Food Chem Toxicol 2019 Apr 19. Epub 2019 Apr 19.

Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Contrary to the safe usage of probiotics for years, their threat is still worthy of attention. Several risks have been explained or mentioned in the case reports, clinical trials and experimental studies. Due to a large number of probiotic products worldwide, the certainty of the safety of such products is a matter of concern. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fct.2019.04.032DOI Listing
April 2019
1 Read

Prevalence and impact of malnutrition in patients surgically treated for chronic mesenteric ischemia.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of vascular surgery, Besançon University Hospital, Besançon, France; EA3920, Besançon University Hospital, Besançon, France. Electronic address:

Objectives: The patients suffering from chronic mesenteric ischemia are at risk of malnutrition due to the fear of food and the weight loss. However the impact of malnutrition on the morbi-mortality at the time of surgery remains little studied, just as its prevalence. The main objective of this study was to evaluate the influence of malnutrition on the survival of the patients operated for chronic mesenteric ischemia. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08905096193023
Publisher Site
http://dx.doi.org/10.1016/j.avsg.2019.02.009DOI Listing
April 2019
1 Read

Thrombolysis for Management of Phlegmasia Cerulea Dolens in the First Trimester of Pregnancy.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Northwest Community Hospital, Arlington Heights IL.

Introduction: Pregnancy is a hypercoagulable state associated with a fivefold increase in risk of venous thromboembolism. Thrombolysis is the preferred level of care for patients with acute ilio-femoral deep vein thrombosis, however most studies exclude pregnant patients, highlighting the lack of data regarding the efficacy and safety of thrombolytic therapy for the mother and fetus.

Case Report: We describe successful use of thrombolytic therapy in conjunction with ultrasound to remove a large ileo-femoral deep vein thrombosis (DVT) in a first trimester patient with phlegmasia cerulea dolens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2019.01.018DOI Listing

Incidence, management and outcomes of aortic graft infection.R1 Aortic graft infection.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Vascular Surgery, Canberra Hospital, Yamba Drive, Garran, ACT, 2605.

Objectives: Infection complicates 1% of aortic grafts, and although uncommon, the associated morbidity and mortality are significant. We sought to determine risk factors for aortic graft infection (AGI), the long-term outcomes in patients managed both non-operatively and via explantation METHODS: This observational study reviewed sequential aortic grafts (thoracic or abdominal) inserted via open or endovascular (EVAR) means between 2000 and 2017. We used Cox proportional hazards regression analyses to compare risk factors between groups who did and did not acquire an AGI, and recorded method of management, morbidity, mortality, and duration to adverse event RESULTS: There were 883 aortic repairs, 49% were endovascular. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08905096193026
Publisher Site
http://dx.doi.org/10.1016/j.avsg.2019.01.027DOI Listing
April 2019
1 Read

The clinical impact of splanchnic ischemia in patients affected by thoracoabdominal aortic aneurysms treated with fenestrated and branched endograft.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Vascular Surgery, Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Policlinico Sant'Orsola-Malpighi Bologna - Italy.

Introduction: Fenestrated/branched endografts (FB-EVAR) are valid options to treat thoraco-abdominal aortic aneurysms (TAAA). Successful repair requires target-visceral-vessels (TVV) manipulation with possible splanchnic ischemia. Aim of the study was to evaluate the clinical impact of splanchnic ischemia occurring in FB-EVAR for TAAA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2019.01.026DOI Listing

Aspirin-Dependent Platelet Inflammatory Inhibition In Healthy Subjects Decreases Nlrp1 Inflammasome.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Angiology and Vascular Surgery Department. Hospital Universitario de Getafe. Madrid. Spain.

Objective: Inflammation and endothelial dysfunction are implicated in the onset of atherosclerosis. Inflammasome activation takes part in the pathogenesis of the atherosclerotic disease. This study investigated the influence of platelet inflammatory inhibition on the transcription of intracitosolic NLRP-1 inflammasome in endothelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2019.02.008DOI Listing

Hybrid Repair of an Intrathoracic Bi-Lobed Subclavian Artery Aneurysm.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Vascular Surgery, Englewood Hospital, Englewood New Jersey, USA.

Intrathoracic subclavian artery aneurysms are extremely rare, <1% of all aneurysms. The formation of these aneurysms is often multifactorial, with the most common contributing factor being atherosclerosis. This case report describes a right subclavian artery aneurysm that required a surgical hybrid approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2018.12.106DOI Listing

Large Urban Center Improves Out-of-Hospital Cardiac Arrest Survival.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency Medicine, University of Illinois at Chicago. Electronic address:

Background: Large cities pose unique challenges that limit the effectiveness of system improvement interventions. Successful implementation of integrated cardiac resuscitation systems of care can serve as a model for other urban centers.

Methods: This was a retrospective analysis of prospectively collected data of adult cases of non-traumatic cardiac arrest who received treatment by Chicago Fire Department EMS from September 1, 2013 through December 31, 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.resuscitation.2019.04.019DOI Listing

Analysis of genetic and clinical risk factors of post-transplant thrombocytopenia in kidney allograft recipients.

Transpl Immunol 2019 Apr 19. Epub 2019 Apr 19.

Western University of Health Sciences, Pomona, CA, United States; St. Vincent Medical Center, Los Angeles, CA, United States. Electronic address:

Background: Hematological abnormalities after transplantation are complications that may arise after renal transplantation, of which thrombocytopenia is associated with increased risk of bleeding and other complications. The development of thrombocytopenia is affected by various clinical conditions, and the stromal-derived factor 1 (SDF1) and platelet factor 4 (PF4) genes are known to be involved in the production or destruction of platelets. The purpose of this study was to investigate the prevalence of posttransplant thrombocytopenia and its association with other clinical conditions and genetic polymorphisms of SDF1 and PF4 genes a long time after transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trim.2019.04.001DOI Listing
April 2019
1 Read

Identification of arylsulfatase B gene mutations and clinical presentations of Iranian patients with Mucopolysaccharidosis VI.

Gene 2019 Apr 19. Epub 2019 Apr 19.

Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Background: Mucopolysaccharidosis (MPS) type VI, also known as Maroteaux-Lamy syndrome, is an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase B (ARSB) enzyme. Our objectives were to investigate clinical phenotypes and performed molecular studies in Iranian patients with MPS VI, for the first time, in the southwestern Iran.

Methods: We studied 14 cases from 10 unrelated kindreds with MPS VI that were enrolled during 8 years. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03781119193040
Publisher Site
http://dx.doi.org/10.1016/j.gene.2019.04.050DOI Listing
April 2019
1 Read

Novel association of SNP rs479200 in EGLN1 gene with predisposition to preeclampsia.

Gene 2019 Apr 19. Epub 2019 Apr 19.

Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, India. Electronic address:

Objectives: Placental hypoxia is a hallmark of preeclampsia. SNP rs479200 in the EGLN1 gene is associated with reduced responsiveness to hypoxia. Whether this translates into an association between SNP rs479200 and preeclampsia is not known. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03781119193040
Publisher Site
http://dx.doi.org/10.1016/j.gene.2019.04.049DOI Listing

Nonbullous pemphigoid: insights in clinical and diagnostic findings, treatment responses and prognosis.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

University of Groningen, University Medical Center Groningen, Department of Dermatology, Center for Blistering Diseases, Groningen, The Netherlands.

Background: Nonbullous pemphigoid is an under-recognized phenotype of the autoimmune bullous disease pemphigoid, characterized by the absence of blisters. Several disease aspects have not been studied previously.

Objective: To describe the characteristics of nonbullous pemphigoid. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.04.029DOI Listing

Chronological order of appearance of immune mediated inflammatory diseases relative to diagnosis of psoriasis.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Denmark. Electronic address:

Background: Psoriasis is a common inflammatory skin disease which is associated with several immune-mediated inflammatory diseases (IMIDs), however little is known of the chronology of the disease development.

Objective: To investigate the chronology of IMIDs relative to psoriasis.

Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n=10,923) and general population controls (n=109,230). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.04.033DOI Listing

The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult, longstanding disease.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street, Chicago, IL 60611, USA. Electronic address:

Background: Despite increasing evidence that adults with longstanding atopic dermatitis (AD) have systemic inflammation, little is known about systemic inflammation in recent-onset early pediatric AD.

Objective: To analyze blood inflammatory proteins of early pediatric AD.

Methods: Using high-throughput proteomics (proximity extension assay), we assessed 257 inflammatory and cardiovascular risk proteins in blood of 30 children with moderate-to-severe AD <5 years of age (within 6 months of onset), compared to age-matched pediatric controls and adult AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.04.036DOI Listing

Risk of bias assessments for selective reporting were inadequate in the majority of Cochrane reviews.

J Clin Epidemiol 2019 Apr 19. Epub 2019 Apr 19.

Center for Evidence-Based Medicine and Health Care, Catholic University of Croatia, Zagreb, Croatia. Electronic address:

Objective: To analyze adequacy of risk of bias (RoB) judgments for selective reporting in Cochrane systematic reviews..

Study Design And Setting: We extracted RoB assessments, including judgment (low, high or unclear risk) and supporting comment from Cochrane reviews of randomized controlled trials using computer parser. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08954356183113
Publisher Site
http://dx.doi.org/10.1016/j.jclinepi.2019.04.007DOI Listing
April 2019
1 Read

Increased susceptibility to pertussis in adults at childbearing age as determined by comparative seroprevalence study, China 2010-2016.

J Infect 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Microbiology, Capital Medical University, Beijing, China; Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland. Electronic address:

Objectives: This study was aimed to determine pertussis specific serum PT-IgG antibodies in healthy individuals during 2010 and 2015/2016 in Beijing, China.

Methods: A total of 3884 healthy individuals were included: 3058 aged 3 to 69 years randomly selected from an epidemiological survey conducted in 2010, and 826 aged 20-39 years selected from those who attended an annual medical examination in 2015/2016. Serum PT-IgG antibodies were determined using the Serion/Virion ELISA kits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinf.2019.04.011DOI Listing

Dietary risk evaluation of tetraconazole and bifenazate residues in fresh strawberry from protected field in North China.

Regul Toxicol Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Beijing Key Laboratory of New Technology in Agricultural Application, College of Plant Science and Technology, Beijing University of Agriculture, Beijing, 102206, China. Electronic address:

Residues and dietary risk assessment of tetraconazole and bifenazate were investigated in strawberry under greenhouse conditions using high performance liquid chromatography (HPLC-DAD) after QuEChERs extraction in Beijing of China. The effects of different processing factors on the two pesticides were studied. The recoveries of tetraconazole and bifenazate were 87. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yrtph.2019.04.008DOI Listing

Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT).

Toxicology 2019 Apr 19. Epub 2019 Apr 19.

Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address:

Many psychoactive substances affect the human dopamine (DA) reuptake transporter (hDAT). Polymorphisms in the encoding gene could affect the functionality of the transporter and consequently alter effects of psychotropic and recreational drugs. Recently, a T356 M single nucleotide polymorphism in the human SLC6A3 gene was described, which resulted in functional impairments of DA uptake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tox.2019.04.012DOI Listing

Investigation of Postoperative Complications of Intrabony Cystic Lesions in Oral and Maxillofacial Region.

J Oral Maxillofac Surg 2019 Mar 28. Epub 2019 Mar 28.

Professor, Department of Oral and Maxillofacial Surgery, Seoul National University School of Dentistry and Dental Research Institute, Seoul, Korea. Electronic address:

Purpose: The purpose of this study was to identify factors that can complicate the surgical removal of intrabony cysts and any relevant correlations between them.

Patients And Methods: The medical records of 249 patients who underwent surgical removal of intrabony cysts were retrospectively reviewed. Outcome variables were postoperative complications, infection, and recurrence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joms.2019.03.022DOI Listing

Detection rates of dysplasia in patients with inflammatory bowel disease using dye-based chromoendoscopy compared with standard- and high-definition white-light colonoscopy: a systematic review and meta-analysis.

Gastrointest Endosc 2019 Apr 19. Epub 2019 Apr 19.

Division of Gastroenterology, Beth Israel Deaconess Medical Center.

Background: Patients with ulcerative colitis have an increased risk of colorectal cancer. We sought to assess the comparative efficacy of standard white-light endoscopy (SDWLE) or high-definition white-light endoscopy (HDWLE) versus dye-based chromoendoscopy through a meta-analysis and rating the quality of evidence using the GRADE system.

Methods: A systematic review of the literature in PubMed, EMBASE, and Web of Sciences was performed through April 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gie.2019.04.219DOI Listing

Posttraumatic Stress Disorder and Expectations of Parenthood and Children's Development.

J Trauma Stress 2019 Apr;32(2):277-286

Department of Psychological Sciences, University of Missouri-St. Louis, St. Louis, Missouri, USA.

Posttraumatic stress disorder (PTSD) may increase the risk of adverse parenting-related outcomes. Research has not determined if PTSD symptoms correspond with more negative expectations of parenthood and unrealistic beliefs regarding children's developmental milestones. Negative and unrealistic preparenthood and developmental expectations are tied to problematic parenting-related outcomes; thus, these beliefs are important to examine within the context of PTSD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jts.22398DOI Listing

Treating ultra-orthodox adolescents with eating disorders in Israel: Culturally-sensitive interventions, difficulties, and dilemmas.

J Clin Psychol 2019 Apr 22. Epub 2019 Apr 22.

Medical School, Ben Gurion University of the Negev, Beer Sheva, Israel.

Young ultra-Orthodox women in Israel have been faced in recent years with a greater risk of developing disordered eating, as they are more exposed to Westernized norms of the thin-body ideal, self-realization, and personal choice. Most are treated by mainstream Israeli psychotherapists who likely have different value systems and different perspectives on the nature of the illness, aims of treatment, and recovery. Ultra-Orthodox psychotherapists may well experience a conflict between a need to be loyal to their patients and a concomitant need to honor the values of patients' families and the community from which they come. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jclp.22790DOI Listing

Rapid profiling of triglycerides in human breast milk using LESA-FTMS reveals new VLCFAs and differences within individuals.

Rapid Commun Mass Spectrom 2019 Apr 22. Epub 2019 Apr 22.

Nutrition and Bone Health group MRC HNR, Cambridge, CB1 9NL, United Kingdom.

Rationale: In this paper, we describe a novel method for preparing milk samples and profiling the triglyceride fraction from them. This method was used to explore how the triglyceride (TG) profile of milk modulates as lactation progresses and how the TG profile differs between breasts.

Methods: Fresh milk was spotted onto Whatman filter paper and air-dried. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcm.8465DOI Listing

Ambivalence in the Early Years of Marriage: Impact on Ambulatory Blood Pressure and Relationship Processes.

Ann Behav Med 2019 Apr 22. Epub 2019 Apr 22.

Mannheim Institute of Public Health, Universität Heidelberg, Heidelberg, Germany.

Background: Marriage is associated with lower cardiovascular morbidity and mortality, but quality matters. Marriages characterized by ambivalent behaviors (containing both highly positive and highly negative behaviors concurrently) may not confer the same cardiovascular benefits as characterized by purely positive behavior. Ambivalence is assumed to take time to develop but couples in the early years of marriage may already exhibit ambivalent behaviors and thus be at increased risk for future cardiovascular events. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/abm/advance-article/doi/10.1093/abm
Publisher Site
http://dx.doi.org/10.1093/abm/kaz017DOI Listing
April 2019
1 Read
  • Page 1 of 47769