2,326,818 results match your criteria Risk Management and Healthcare Policy [Journal]


An approach to identifying the relative importance of different radionuclides in ecological radiological risk assessment: Application to nuclear power plant releases.

J Environ Radioact 2018 Dec 12;197:116-126. Epub 2018 Dec 12.

IRSN, PSE-ENV, Fontenay aux Roses, France.

There is a need to prioritise the requirements for data to assess the radiological risk for fauna and flora, as inevitable large data gaps occur due to the large number of combinations of radionuclides and organisms for which doses need to be assessed. The potentially most important dose-forming radionuclide-pathways combinations need to be identified to optimize filling these gaps. Few attempts have been made to classify the importance of isotopes with regard to radiation protection of the environment. Read More

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December 2018

Differential exposure to organophosphate flame retardants in mother-child pairs.

Chemosphere 2018 Dec 4;219:567-573. Epub 2018 Dec 4.

Departmentof Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA. Electronic address:

Background: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.

Objectives: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. Read More

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December 2018

Concentrations, speciation, and ecological risk of heavy metals in the sediment of the Songhua River in an urban area with petrochemical industries.

Chemosphere 2018 Dec 10;219:538-545. Epub 2018 Dec 10.

Jilin Institute of Chemical Technology, Jilin, 132022, China. Electronic address:

In this study, the pollution status and the ecological risks of heavy metals (Cu, Zn, Pb, Ni and Cr) in the sediments of the Songhua River in an urban area with petrochemical industries were assessed. The highest mean concentration of total heavy metals occurred in the freezing period, and the highest total heavy metal concentrations were observed near the petrochemical industrial area. The geo-accumulation index indicated that Cu was the most contaminated heavy metal. Read More

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December 2018

Risk factors for mortality and cost implications of complicated intra-abdominal infections in critically ill patients.

J Crit Care 2018 Dec 12;50:169-176. Epub 2018 Dec 12.

Dipartimento di Scienza dell'Emergenza, Anestesiologiche e della Rianimazione - UOC di Anestesia, Rianimazione, Terapia Intensiva e Tossicologia Clinica - Istituto di Anestesia e Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma - Università Cattolica del Sacro Cuore, Italy. Electronic address:

Purpose: To assess risk factors for 28-day mortality and cost implications in intensive care unit (ICU) patients with complicated intra-abdominal infections (cIAIs).

Methods: Single-center retrospective cohort study of prospectively collected data analysing ICU patients with a microbiologically confirmed complicated intra-abdominal infections.

Results: 137 complicated intra-abdominal infections were included and stratified according to the adequacy of antimicrobial therapy (initial inadequate antimicrobial therapy [IIAT], n = 44; initial adequate antimicrobial therapy [IAAT], n = 93). Read More

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December 2018

The influence of bed-sharing on infant physiology, breastfeeding and behaviour: A systematic review.

Sleep Med Rev 2018 Nov 16;43:106-117. Epub 2018 Nov 16.

Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, New Zealand. Electronic address:

This review aimed to better understand the underlying physiology of the risks and benefits of bed-sharing. Eight databases were searched using terms relating to adult-infant/baby, bed-sharing/co-sleeping combined with outcome terms for physiology, sleep, cardiovascular, respiratory, temperature and behaviour. Of 836 papers identified, 59 papers representing 48 cohorts met inclusion criteria. Read More

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November 2018
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Detection and quantification of methicillin-resistant Staphylococcus aureus in fresh broiler meat at retail in Germany.

Int J Food Microbiol 2018 Nov 22;292:8-12. Epub 2018 Nov 22.

German Federal Institute for Risk Assessment (BfR), Department Biological Safety, Berlin, Germany. Electronic address:

The aim of this study was to detect, to quantify and to characterize MRSA in broiler meat samples with skin. Furthermore, we compared an isolation method using a second selective enrichment step (method A) with a simpler method omitting this step (method B). For quantification we used a direct plating method on selective agar plates and a "Most probable number" (MPN) technique for estimation of low numbers of MRSA. Read More

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November 2018
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Distribution of mycotoxins produced by Penicillium spp. inoculated in apple jam and crème fraiche during chilled storage.

Int J Food Microbiol 2018 Dec 7;292:13-20. Epub 2018 Dec 7.

University of Natural Resources and Life Sciences, Vienna (BOKU), Department of Agrobiotechnology (IFA-Tulln), Center for Analytical Chemistry, Konrad-Lorenz-Str. 20, 3430 Tulln, Austria.

Estimations of consumer exposure to mycotoxins through surveillance of mycotoxins in the food trade are well described, but the exposure due to mouldy food in private homes is not known, and may result from removing visible mould on food and eating the rest. In this study, we followed the growth of Penicillium expansum on the surface of apple jam and Penicillium verrucosum on crème fraiche, as well as production and distribution of fungal metabolites throughout the sample (approx. 6 cm high divided into three equal layers), using a multianalyte method, over time (up to 28 days) and at 4, 8 and 15 °C. Read More

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December 2018
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Polyphasic characterization of Epicoccum sorghinum: A tenuazonic acid producer isolated from sorghum grain.

Int J Food Microbiol 2018 Dec 7;292:1-7. Epub 2018 Dec 7.

Laboratory of Mycotoxins and Toxigenic Fungi, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

Epicoccum sorghinum isolates from sorghum grain grown in Brazil were characterized using a polyphasic approach based on morphological, genetic and physiologic features. A considerable intraspecific variability was observed. The phylogenetic analysis showed that the 53 isolates studied formed four distinct clades, and their morphological features revealed a high variability in culture. Read More

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December 2018

Delays in the reading and spelling of children with cerebral palsy: Associations with phonological and visual processes.

Res Dev Disabil 2018 Dec 12;85:131-142. Epub 2018 Dec 12.

Open University, Walton Hall, Milton Keynes MK7 6AA, United Kingdom.

Background: This investigation addresses the question of whether there exists a significant discrepancy in the cognitive abilities of children with cerebral palsy (CP) who, despite the presence of age appropriate communication and language, have reading and spelling delays.

Aims: We wanted to discover whether there was a relationship between the phonological and visual perceptual abilities of children with CP and their progress in reading and spelling.

Methods And Procedures: Fifteen children with CP (aged between 6:9 years and 11:6 years) were assessed on reading and spelling; communication and language; non-verbal reasoning; phonological processing; and visual perception. Read More

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December 2018

Molecular alterations in meningiomas: Literature review.

Clin Neurol Neurosurg 2018 Dec 7;176:89-96. Epub 2018 Dec 7.

Departament of Neurology, Laboratory of Molecular and Cellular Biology, LIM15, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil.

Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system neoplasms. According to the 2016 WHO classification of central nervous system tumors meningiomas are classified into three grades: I, II, and III. Past studies have shown that the risk of meningiomas recurrence is strongly correlated with the molecular profile of the tumor. Read More

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December 2018

Gut microbiota-dependent trimethylamine-N-oxide (TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism.

Thromb Res 2018 Dec 6;174:40-47. Epub 2018 Dec 6.

Center for Molecular Cardiology, Laboratory for Platelet Research, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland. Electronic address:

Introduction: Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with arterial thrombotic events including myocardial infarction and stroke, and mortality. However, the association of TMAO with recurrent venous thromboembolism (VTE) and mortality remains unknown.

Methods: TMAO plasma levels were assessed by high performance liquid chromatography in 859 patients aged ≥65 years with acute VTE and categorized into low (<2. Read More

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December 2018
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Post-thrombotic syndrome and recurrent thromboembolism in patients with upper extremity deep vein thrombosis: A systematic review and meta-analysis.

Thromb Res 2018 Dec 8;174:34-39. Epub 2018 Dec 8.

Department of Medicine, Division of Hematology, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. Electronic address:

Introduction: There is limited data on the occurrence of complications in patients with upper extremity deep vein thrombosis (UEDVT).

Aims: We aimed to determine the frequency of post-thrombotic syndrome (PTS), thrombosis recurrence and major bleeding (MB) in patients with UEDVT.

Material And Methods: We conducted a systematic review of the literature including studies from 1970 onwards. Read More

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December 2018
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Prescription patterns of direct oral anticoagulants in pulmonary embolism: A prospective multicenter French registry.

Thromb Res 2018 Dec 8;174:27-33. Epub 2018 Dec 8.

Department of Cardiology, EA3920, University Hospital Besançon, Boulevard Fleming, 25030 Besançon, France. Electronic address:

Background: Data regarding the use of direct oral anticoagulants (DOACs) for the treatment of acute pulmonary embolism (PE) are sparse. We conducted a prospective multicentre registry study to describe patterns of DOAC prescription for the treatment of acute PE, and the associated risk of 6-month adverse events in daily practice.

Methods: We included all PE patients discharged since the availability of DOACs for the dedicated indication of acute PE treatment. Read More

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December 2018

The association between the longitudinal course of common mental disorders and subsequent physical activity status in young adults: A 30-year birth cohort study.

J Psychiatr Res 2018 Dec 6;109:173-177. Epub 2018 Dec 6.

Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia; School of Public Health, The University of Queensland, Herston, Australia; Metro North Mental Health, Royal Brisbane and Women's Hospital, Herston, Australia.

Low physical activity is a major public health concern. There has been extensive research examining the role of physical activity as a potentially modifiable risk factor for the onset of mental illness. However, fewer studies have reported how mental disorders affect future physical activity. Read More

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December 2018
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Home monitoring with IT-supported specialist management versus home monitoring alone in patients with heart failure: Design and baseline results of the SUPPORT-HF 2 randomized trial.

Authors:

Am Heart J 2018 Sep 25;208:55-64. Epub 2018 Sep 25.

The George Institute for Global Health, University of Oxford, 1st Floor, Hayes House, 75 George St, Oxford, United Kingdom.

Objectives: SUPPORT-HF 2 tests the hypothesis that home monitoring with information technology-supported specialist management is more effective in optimizing medical therapy than is home monitoring alone for patients with heart failure.

Methods And Results: The study was designed as a 2-armed partially blinded parallel randomized controlled trial. Seven sites in the United Kingdom (UK) recruited a total of 202 adults with heart failure at high risk of adverse outcomes and with potential to benefit from remote management (mean age 73 years, 28% female, median left ventricular ejection fraction 37%). Read More

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September 2018
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Predictive factors associated with driving under the influence among Brazilian drug-using drivers.

Accid Anal Prev 2018 Dec 12;123:256-262. Epub 2018 Dec 12.

Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Rua Professor Álvaro Alvim, 400, 90420-020, Porto Alegre, RS, Brazil.

The incidence of driving under the influence of psychoactive substances (DUI) and its recidivism can be curtailed by the proper identification of specific and predictive characteristics among drug users. In this sense, interpersonal violence (IV), psychiatric comorbidity and impulsivity seem to play an important role in DUI engagement according to previous studies. There are, however, limited data originated from low and middle income countries. Read More

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December 2018

Predictors of self-harm emergency department visits in adolescents: A statewide longitudinal study.

Gen Hosp Psychiatry 2018 Dec 8;56:28-35. Epub 2018 Dec 8.

Violence Prevention Research Program, University of California, Davis, Sacramento, CA 95817, USA. Electronic address:

Objective: This study investigated patient- and area-level characteristics associated with adolescent emergency department (ED) patients' risk of subsequent ED visits for self-harm.

Method: Retrospective analysis of adolescent patients presenting to a California ED in 2010 (n = 480,706) was conducted using statewide, all-payer, individually linkable administrative data. We examined associations between multiple predictors of interest (patient sociodemographic factors, prior ED utilization, and residential mobility; and area-level characteristics) and odds of a self-harm ED visit in 2010. Read More

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December 2018

Effectiveness of Fosfomycin Tromethamine Prophylaxis in Preventing Infection Following Ultrasound-guided Prostate Needle Biopsies: Results from a Large Canadian Cohort.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology and Infectious Diseases, Université de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4,. Electronic address:

Background: Rates of infection following ultrasound-guided transrectal prostate needle biopsy (TRUSPB) are increasing. We aimed to evaluate the effectiveness of fosfomycin tromethamine (FMT) prophylaxis in preventing post-TRUSPB infectious complications.

Methods: This nested case-control study included patients who underwent TRUSPB in a Canadian tertiary care hospital, and developed post-TRUSPB bacteremia or urinary tract infections. Read More

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December 2018

Bundle payment model in spine surgery: Current challenges and opportunities, a systematic review.

World Neurosurg 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, University of Louisville, 200 Abraham Flexner Hwy, Louisville, KY, U.S.A- 40202. Electronic address:

Introduction: Bundled payments offer a lump sum for management of particular conditions over a specified time period that has the potential to reduce healthcare payments. Additionally, bundled payments represent a shift toward patient-centered reimbursement that has the upside of improved care coordination among providers and may lead to improved outcomes.

Aim: To review the challenges and sources of payment variation and opportunities for restructuring bundled payments plans in context of spine surgery. Read More

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December 2018
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Are parents at a higher risk for secondary traumatic stress?: How interviewing child victims impacts relationships with forensic interviewer's friends and family.

Child Abuse Negl 2018 Dec 12;88:275-287. Epub 2018 Dec 12.

School of Arts & Sciences, University of Houston-Victoria, 3007 N. Ben Wilson, Victoria, TX, 77904, United States. Electronic address:

Background: Forensic interviewers are at a heightened risk for secondary traumatic stress (STS) due to their frequent interactions with victims of child maltreatment (Bonach & Heckert, 2012). To date, however, few studies have examined the negative effects of this work on interviewers' social and emotional well-being.

Objective: The present study seeks to explore the effect of STS on the relationships of forensic interviewers, including those with friends, family, and their respective children. Read More

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December 2018

Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Pu-erh Tea Science, the Ministry of Education, Yunnan Agricultural University, Kunming 650201, China; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Kunming, China; Pu'erh Tea Research Institute, Pu'erh, China. Electronic address:

Caffeine intake is associated with a reduced risk developing non-alcoholic fatty liver disease (NAFLD), but the underlying molecular mechanisms remain to be fully elucidated. We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver. Interestingly, the expression of IL-6 mRNA was not increased in the liver, but increased substantially in the muscles of caffeine-treated mice. Read More

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December 2018
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Perineal prevention and protection in obstetrics: CNGOF Clinical Practice Guidelines.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Obs/Gyn, Epidemiologist. INSERM CIC1402, Université de Poitiers, CHU de Poitiers, France. Electronic address:

Introduction: The objective of these clinical practice guidelines was to analyse all of the interventions during pregnancy and childbirth that might prevent obstetric anal sphincter injuries (OASIS) and postnatal pelvic floor symptoms.

Material And Methods: These guidelines were developed in accordance with the methods prescribed by the French Health Authority (HAS).

Results: A prenatal clinical examination of the perineum is recommended for women with a history of Crohn's disease, OASIS, genital mutilation, or perianal lesions (professional consensus). Read More

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December 2018

Epidemiology and etiology of diarrhea in UK military personnel serving on the United Nations Mission in South Sudan in 2017: A prospective cohort study.

Travel Med Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Academic Department of Military Medicine, Medical Directorate, Defence Medical Services, Birmingham, UK.

Background: . Diarrhea is a well-established problem in travellers, with military personnel at especially high risk. This study aimed to characterise the spectrum of pathogens causing diarrhea in UK military personnel in South Sudan, and assess the utility of culture-independent testing for etiology and antimicrobial resistance in a logistically challenging and austere environment. Read More

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December 2018

Zika Virus Diagnosis: Challenges and Solutions.

Clin Microbiol Infect 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, University of Miami Miller School of Medicine. Miami, FL, 33133 USA.

Background: Since its sudden appearance and link to microcephaly in 2015, the number of PubMed references for Zika virus (ZIKV) has risen from 181 to 5,163, as of writing, with a vast proportion focused on the consequences of ZIKV infection during pregnancy. This level of attention underlies increased demand for sensitive and specific diagnostic tools able to assess risk to an unborn child, as well as to understand the dynamics and consequences of viral persistence.

Aim: Review the expanding knowledge on ZIKV persistence and diagnostic challenges and summarize current advancements in detection. Read More

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December 2018

Clinical relevance of enteropathogen co-infections in preschool children - a population-based repeated cross-sectional study.

Clin Microbiol Infect 2018 Dec 12. Epub 2018 Dec 12.

Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

Objectives: This study aimed to (i) determine risk factors for enteropathogen co-infections, (ii) determine whether enteropathogen co-infections influence gastroenteritis risk, and (iii) determine whether enteropathogen co-infection occurred randomly in preschool children.

Methods: A monthly-repeated cross-sectional survey in Dutch children aged 0-48 months was conducted during October 2012-October 2014. 981 stool samples were collected along with questionnaires collecting data on gastrointestinal symptoms and potential risk factors. Read More

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December 2018

Automated small-scale in vitro transfer model as screening tool for the prediction of in vivo-dissolution and precipitation of poorly solubles.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Institute of Pharmacy, Department of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Strasse 3, 17489 Greifswald, Germany. Electronic address:

Precipitation testing, especially for weakly basic APIs, represents a key parameter in drug substance characterization during early development stages, where the amount of API available is limited. Therefore, it was the aim of this study to develop an automated small-scale in vitro transfer model to characterize the supersaturation and precipitation behavior of two poorly water-soluble drugs. Following automation and scale-down of the standard transfer model, the developed small-scale model was used to assess the impact of gastrointestinal variability, i. Read More

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December 2018

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address:

Quizartinib, a second-generation FLT3 inhibitor, is in clinical development for the treatment of acute myeloid leukemia. We studied its pharmacokinetic interactions with the multidrug efflux transporters ABCB1 and ABCG2 and the multidrug metabolizing enzyme CYP3A, using in vitro transport assays and knockout and transgenic mouse models. Quizartinib was transported by human ABCB1 in vitro, and by mouse (m)Abcb1 and mAbcg2 in vivo. Read More

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December 2018

ω-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitisation in offspring: a systematic review and meta-analysis.

Ann Allergy Asthma Immunol 2018 Dec 12. Epub 2018 Dec 12.

University of Portsmouth School of Health Sciences and Social Work.

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December 2018

Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Given the multifactorial state of autoimmune complex diseases such as multiple sclerosis (MS), it is not clear if different risk factors act jointly or independently. Despite intensive studies investigating multi aspects of MS risk factors, findings with regards to potential biomarkers that may link these risk factors remained largely inconclusive. System biology or data integration utilizes different validated datasets to extract meaningful information and map the plausible biological pathways and networks. Read More

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December 2018

Intestinal parasites and lungworms in stray, shelter and privately owned cats of Switzerland.

Parasitol Int 2018 Dec 12. Epub 2018 Dec 12.

University of Zurich, Vetsuisse Faculty, Institute of Parasitology, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:

Endoparasitic infections represent relevant causes of respiratory and gastrointestinal diseases in cats. The aim of the study was to investigate the occurrence of endoparasites in Swiss cats in order to evaluate the risk of onset of parasitic diseases and potential correlated zoonoses. Therefore 664 faecal samples from privately owned (n = 299), shelter (n = 197) and stray (n = 168) cats were investigated by sedimentation-flotation and 468 samples additionally by the Baermann technique. Read More

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December 2018

Osteoarthritis Year in Review 2018: biomarkers (biochemical markers).

Osteoarthritis Cartilage 2018 Dec 12. Epub 2018 Dec 12.

Biomarker and research, Nordic Bioscience, Herlev, Denmark. Electronic address:

Objective: The aim of this narrative review is to summarize important findings from biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries and clinical and scientific need.

Design: We conducted a systematic search of electronic medical databases (Embase, Medline, Web of Science, Cochrane central) between 01-03-2017 and 31-03-2018. The search was restricted to human studies, English language and full text available publications while reviews were excluded. Read More

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December 2018

Long-term outcomes for patients with desmoid fibromatosis treated with radiation therapy: a 10-year update and re-evaluation of the role of radiation therapy for younger patients.

Int J Radiat Oncol Biol Phys 2018 Dec 12. Epub 2018 Dec 12.

Departments of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX.

Objective: To update our experience with long-term outcomes in patients with desmoid fibromatosis treated with radiation therapy (RT) and to characterize factors associated with increased risk of local recurrence.

Methods: We reviewed the records of 209 consecutive patients with desmoid fibromatosis treated with RT, either alone or as combined modality therapy (CMT) with surgery, at our institution from 1965 to 2015.

Results: Median follow-up time was 98 months (range, 1-509 months). Read More

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December 2018

Women's perspectives about cannabis use during pregnancy and the postpartum period: An integrative review.

Prev Med 2018 Dec 12. Epub 2018 Dec 12.

University of British Columbia, Vancouver, BC, Canada.

Cannabis is the most commonly used illicit drug among general and pregnant populations. Despite recommendations to abstain from cannabis use, its use is increasing during the perinatal period. In this integrative review, we aim to understand women's perspectives about the health aspects of perinatal cannabis use. Read More

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December 2018
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Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group than PI-RADS Score in Multi-Parametric Prostate MRI-Ultrasound Fusion Targeted Biopsies.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Yale School of Medicine, New Haven, CT. Electronic address:

Objective: To assess the association between Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) score, the Decipher score and histologic grade of carcinoma in biopsy tissue among low- to intermediate-risk prostate cancer patients.

Methods: MRI-ultrasound targeted biopsy of regions of interest and concurrent 12-core systematic biopsy was performed on men with Gleason grade group (GG) 1 and 2. We compared Decipher score with PI-RADS scores and biopsy Gleason GG. Read More

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December 2018

Non-Muscle Invasive Bladder Cancer Influences Physical Health Related Quality of Life and Urinary Incontinence.

Urology 2018 Dec 12. Epub 2018 Dec 12.

University of Washington, Department of Urology. Electronic address:

Objective: To evaluate the effects of non-muscle invasive bladder cancer (NMIBC) on health-related quality of life (HRQOL) and urinary function within patients diagnosed with NMIBC as compared to the general population.

Methods: Using the Surveillance, Epidemiology, and End Results-Medicare Health Outcome Survey (SEER-MHOS) database (1998-2013), 325 patients diagnosed with NMIBC with baseline and post-diagnosis MHOS surveys were propensity-matched 1:5 to non-cancer controls (NCC). Multivariate linear regression analysis compared NMIBC patients with matched NCC in terms of physical component summary (PCS), mental component summary (MCS), and health domain scales. Read More

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December 2018

Pathophysiological Mechanisms Implicated in Postpartum Depression.

Front Neuroendocrinol 2018 Dec 12. Epub 2018 Dec 12.

Department of Neuroscience, Tufts University School of Medicine, Boston, MA, 02111, USA. Electronic address:

This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinnings. The evidence supporting a role for neuroendocrine changes, neuroinflammation, neurotransmitter alterations, circuit dysfunction, and the involvement of genetics and epigenetics in the pathophysiology of postpartum depression are discussed. Read More

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December 2018

Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: the effect of NOD2/CARD15 mutations in a Tunisian population.

Hum Immunol 2018 Dec 12. Epub 2018 Dec 12.

Immunogenetic Applied to Cells Therapy Research Unit, Immuno-Haematology and HLA-Typing Department, National Blood Transfusion Centre of Tunis, Tunis, Tunisia.

Bronchiolitis obliterans (BO) is a serious lung complication that can develop after allogenic stem cell transplantation. It has been suggested that single nucleotide polymorphisms (SNPs) that affect the NOD2/CARD15 gene impair its function and result in an uncontrolled innate immune response in the recipient, thereby leading to BO. One hundred eighty-one donor-recipient pairs were analyzed for the association between NOD2 gene variants (SNP8 [Arg702Trp], SNP12 [Gly908Arg], and SNP13 [Leu1007fsinsC]) and the occurrence of BO. Read More

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December 2018

The influence of the OPRM1 (A118G) polymorphism on behavioral and neural correlates of aggression in healthy males.

Neuropharmacology 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen University, 52074, Aachen, Germany; JARA Institute Brain Structure Function Relationship Institute for Neuroscience and Medicine (INM 10), Forschungszentrum Jülich, 52425 Jülich, Germany.

Current models of aggression suggest that in addition to personality traits and environmental factors, biological vulnerability associated with genetics substantially impacts aggressive behavior. In a functional imaging study, we investigated the influence of the single nucleotide polymorphism of the mu 1 subtype opioid receptor gene (OPRM1), implicated in sociability, on correlates of trait and state aggression to delineate the function of these influences in aggression. A key aim was further to differentiate different aspects of aggressive reactions - namely, the reaction to provocation and the decision to punish an opponent. Read More

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December 2018

Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.

Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:

Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More

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December 2018
16.716 Impact Factor

The Impact of Prefilled Syringes on Endophthalmitis following Intravitreal Injection of Ranibizumab.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Mid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Purpose: To compare the rates of infectious endophthalmitis following intravitreal injection of ranibizumab using prefilled syringes vs. conventional preparation.

Design: Multicenter, retrospective, cohort study METHODS: All eyes receiving intravitreal injection of 0. Read More

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December 2018

Management of invasive squamous cell carcinomas of the conjunctiva Treatment of invasive conjunctival carcinoma.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Pasteur 2 Teaching Hospital, Nice, France.

Purpose: Ocular Surface Squamous Neoplasia includes a spectrum of diseases from dysplasia to invasive squamous cell carcinoma of the conjunctiva. Whether the degree of invasion influences outcomes is debated. We evaluated the outcomes and management of conjunctival carcinomas defined as ≤0. Read More

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December 2018

Open Thoracoabdominal Aortic Aneurysm Repair: Contemporary Outcomes for 393 Elective Cases.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Japan.

Background: The purpose of this study was to reveal the mid- and long-term mortality rates among patients with thoracoabdominal aortic aneurysm (TAAA) following open TAAA repair (TAAAR) and to clarify the impact of aneurysm type on mortality.

Methods: We retrospectively analyzed data for 393 patients (290 males; age, 63.2 ± 12. Read More

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December 2018

IgG reactivity with 40-35 kDa soluble and membrane antigen of Strongyloides venezuelensis in immunocompromised patients.

Acta Trop 2018 Dec 12. Epub 2018 Dec 12.

Laboratório de Investigação Médica (LIM/06 - Laboratório de Imunopatologia da esquistossomose), Hospital das Clínicas da Faculdade de Medicina, USP, São Paulo, Brazil; Instituto de Medicina Tropical de São Paulo, USP, São Paulo, Brazil.

Immunocompromised patients constitute a risk group for the development of severe clinical forms of human strongyloidiasis. The diagnosis of this infection is primarily performed by parasitological techniques, but with low sensitivity. Serological techniques appear as an alternative, especially with heterologous antigens use. Read More

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December 2018

Steady state errors and risk of a QC strategy.

Clin Biochem 2018 Dec 12. Epub 2018 Dec 12.

RCPA Quality Assurance Programs, St Leonards, Sydney, NSW, Australia 2065. Electronic address:

Background: To minimise the risk of patient harm from results, laboratories should establish QC strategies and monitor the performance of assays in line with the analytical and clinical risk.

Methods: Steady state errors were calculated from a distribution normalized for an Analytical Performance Specification expressed as Assay Capability (imprecision) minus Assay Stability (drift). Inverting this error rate gave QC run length containing one error. Read More

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December 2018
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First report of two consecutive respiratory syncytial virus outbreaks by the novel genotypes ON-1 and NA-2 in a neonatal intensive care unit.

J Pediatr (Rio J) 2018 Dec 12. Epub 2018 Dec 12.

Santa Casa de São Paulo, Unidade de Doenças Infecciosas Pediátricas, São Paulo, SP, Brazil.

Objective: Respiratory syncytial virus is a pathogen frequently involved in nosocomial outbreaks. Although several studies have reported nosocomial outbreaks in neonatal intensive care units, molecular epidemiology data are scarce. Here, the authors describe two consecutive respiratory syncytial virus outbreaks caused by genotypes ON-1 and NA-2 in a neonatal intensive care unit in São Paulo, Brazil. Read More

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December 2018

Transitional care for patients with surgical pediatric hepatobiliary disease: choledochal cysts and biliary atresia.

J Gastroenterol Hepatol 2018 Dec 15. Epub 2018 Dec 15.

University of Rochester School of Medicine, Rochester, NY, USA.

Choledochal cysts (CDCs) and biliary atresia (BA) are rare pediatric hepatobiliary anomalies that require surgical intervention due to increased risk of malignancy and liver failure, respectively. The underlying disease and operative procedures place patients at risk for long-term complications, which may continue to affect them into adulthood. Lack of a transitional care model in the health care system potentiates the challenges they will face following aging out of their pediatric providers' care. Read More

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December 2018

Effects of proton pump inhibitors on severe haematotoxicity induced after first course of pemetrexed/carboplatin combination chemotherapy.

J Clin Pharm Ther 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Applied Therapeutics, Center for Education & Research on Clinical Pharmacy, Showa Pharmaceutical University, Tokyo, Japan.

What Is Known And Objective: Pemetrexed/carboplatin combination chemotherapy has shown efficacy as a first-line treatment for advanced non-small-cell lung cancer. However, severe haematotoxicity is often observed during this combination chemotherapy. Some studies have suggested that concomitant drugs may be the risk factors for severe adverse events. Read More

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December 2018

Dual use in the 21st century: emerging risks and global governance.

Swiss Med Wkly 2018 Nov 2;148:w14688. Epub 2018 Dec 2.

Health Ethics and Policy Lab, Department of Health Sciences and Technology, ETH Zurich, Switzerland.

Dual use research of concern (DURC) is defined by the World Health Organization as "life sciences research that is intended for benefit, but which might easily be misapplied to do harm." Ethical and policy discussions on DURC span the past three decades. Today, however, new and emerging technologies and associated sociocultural transformations within the scientific community are reshaping the current risk scenario. Read More

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November 2018
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Three prognostic indexes as predictors of response to adjuvant chemoradiotherapy in patients with oral squamous cell carcinoma after radical surgery: A large-scale prospective study.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.

Background: To develop and validate practical prognostic indexes (PIs) for predicting the prognosis and response to postoperative adjuvant therapy in patients with oral squamous cell carcinoma (OSCC).

Methods: A large cohort of 1071 OSCC patients were randomized to either training set (N = 708) or validation set (N = 363). Three types of PIs were developed according to the nomogram scores, β coefficients and excess hazard ratios, respectively. Read More

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December 2018
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Comparative risk of venous thromboembolism with tofacitinib versus tumor necrosis factor inhibitors: A cohort study of rheumatoid arthritis patients.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

Objective: To evaluate the risk of venous thromboembolism (VTE) with tofacitinib versus tumor necrosis factor (TNF)-inhibitors in rheumatoid arthritis (RA) patients.

Methods: RA patients initiating tofacitinib or a TNF inhibitor without use of any biologic or tofacitinib any time prior were identified from Truven MarketScan (2012-2016) or Medicare claims (parts A, B, and D, 2012-2015) and followed until treatment discontinuation, treatment switch, insurance disenrollment, or administrative censoring. The outcome of VTE was identified using inpatient claims for pulmonary embolism or deep vein thrombosis. Read More

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December 2018
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