42,459 results match your criteria Risk Factors for Coronary Artery Disease


The Association of Coronary Artery Calcification With Subsequent Incidence of Cardiovascular Disease in Type 1 Diabetes: The DCCT/EDIC Trials.

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Biostatistics, George Washington University, Rockville, Maryland.

Objectives: This study sought to determine the relationship between coronary artery calcium (CAC) scores and subsequent cardiovascular disease (CVD) events in DCCT (Diabetes Control and Complications Trial)/EDIC (Epidemiology of Diabetes Interventions and Complications) participants.

Background: The CAC score has been validated for improved risk stratification in general populations; however, this association has not been well studied in type 1 diabetes (T1DM).

Methods: Computed tomography (CT) to measure CAC was performed in 1,205 DCCT/EDIC participants at a mean of 42. Read More

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http://dx.doi.org/10.1016/j.jcmg.2019.01.014DOI Listing

2018 Cholesterol Guidelines: Key Topics in Primary Prevention.

Curr Atheroscler Rep 2019 Mar 16;21(5):17. Epub 2019 Mar 16.

Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.

Purpose Of Review: The 2018 American College of Cardiology (ACC) and American Heart Association (AHA) cholesterol guidelines are a comprehensive update providing recommendations for management of patients with high blood cholesterol based on the best available evidence. This review highlights key topics clinicians need to know for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) based on the 2018 ACC/AHA cholesterol guidelines.

Recent Findings: The guidelines include a broad framework for risk estimation and management for primary prevention of ASCVD. Read More

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http://dx.doi.org/10.1007/s11883-019-0776-8DOI Listing

Gout is associated with a higher risk of chronic renal disease in older adults: a retrospective cohort study of U.S. Medicare population.

BMC Nephrol 2019 Mar 15;20(1):93. Epub 2019 Mar 15.

Department of Medicine at School of Medicine, University of Alabama at Birmingham, 1720 Second Ave. South, Birmingham, AL, 35294-0022, USA.

Background: Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout itself is not known. Studies in older adults, who tend to have a high incidence of CKD, are limited. Read More

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http://dx.doi.org/10.1186/s12882-019-1274-5DOI Listing

Coronary artery disease associated with factor V Leiden mutation: a case report.

Turk Kardiyol Dern Ars 2019 Mar;47(2):148-152

Federal University of Rio de Janeiro, Edson Saad Heart Institute, Rio de Janeiro, RJ, Brasil.

The prevalence of coronary artery disease in young adults (<45 years of age) has been increasing steadily in recent decades. Although traditional cardiovascular risk factors can be identified in most cases, newly recognized associations are becoming progressively more relevant. The relationship between the factor V Leiden mutation and atherosclerosis has been a matter of debate due to conflicting data presented in previous studies. Read More

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http://archivestsc.com/jvi.aspx?un=TKDA-39939
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http://dx.doi.org/10.5543/tkda.2018.39939DOI Listing
March 2019
1 Read

Subclinical thyroid dysfunction and cardiovascular consequences: An alarming wake-up call?

Trends Cardiovasc Med 2019 Mar 5. Epub 2019 Mar 5.

School of Medicine, Athens University, Athens, Greece. Electronic address:

Subclinical thyroid dysfunction (STD), presenting as subclinical hypothyroidism (SHypo) or subclinical hyperthyroidism (SHyper), defined as abnormal serum thyrotropin (TSH) and normal free thyroid hormones, is associated with increased cardiovascular (CV) risk and mortality. Depending on the degree of such dysfunction, atherosclerosis, coronary artery disease, heart failure and cardiac arrhythmias, predominantly atrial fibrillation, characterize both disorders and increase CV and total mortality compared to euthyroid persons. There are some differences in the mechanisms involved in the increased CV risk incurred by each type of STD, with more traditional CV risk factors clustered in SHypo than in SHyper, while the role of the TSH or its absence thereof, together with the respective, even subtle, changes incurred in thyroid hormone concentrations, seem to adversely influence the CV system in both types of STD. Read More

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http://dx.doi.org/10.1016/j.tcm.2019.02.011DOI Listing

Remnant cholesterol and coronary atherosclerotic plaque burden assessed by computed tomography coronary angiography.

Atherosclerosis 2019 Mar 4;284:24-30. Epub 2019 Mar 4.

Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Clayton, Victoria, Australia; Department of Medicine, Monash University, Clayton, Victoria, Australia; Mildura Cardiology, Mildura, Victoria, Australia; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. Electronic address:

Background And Aims: There remains a substantial residual risk of ischaemic heart disease (IHD) despite optimal low-density lipoprotein cholesterol (LDLC) reduction. Part of this risk may be attributable to remnant cholesterol, which is carried in triglyceride-rich lipoproteins. We evaluated the relationship between remnant cholesterol and coronary atherosclerotic plaque burden assessed non-invasively by computed tomography coronary angiography (CTCA) in patients with suspected coronary artery disease (CAD). Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.019DOI Listing
March 2019
3.994 Impact Factor

Risk factors for chemotherapy-related cardiac toxicity.

Curr Opin Cardiol 2019 Mar 11. Epub 2019 Mar 11.

Department of Medicine, University of Chicago Medicine, Chicago, Illinois, USA.

Purpose Of Review: The purpose of this review is to discuss the clinical and treatment-related factors that increase the risk of cardiotoxicity with anthracyclines and human epidermal growth factor 2 receptor inhibitors.

Recent Findings: Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy. Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000619DOI Listing

Relationship between Perioperative Hypotension and Perioperative Cardiovascular Events in Patients with Coronary Artery Disease Undergoing Major Noncardiac Surgery.

Anesthesiology 2019 Mar 8. Epub 2019 Mar 8.

From the Lilibeth Caberto London Kidney Clinical Research Unit, London Health Sciences Centre, London, Canada (P.S.R.) the Department of Medicine, McMaster University, Hamilton, Canada (P.S.R., T.S., E.D., V.T., P.J.D.) Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada(P.S.R., E.D., P.J.D.) the Population Health Research Institute, Hamilton, Canada (E.D., P.J.D.) the Division of General Internal Medicine, McGill University Health Center, Montreal, Canada (A.B.) the Department of Anesthesia and Intensive Care, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China (M.T.V.C.) the Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada (C.B.) the Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada (B.J.W.C.) the Department of Radiology, University of Ottawa, Ottawa, Canada (B.J.W.C.) the Department of Anesthesia, University of Toronto, Toronto, Canada (J.S.K).

What We Already Know About This Topic: Perioperative hypotension is associated with cardiovascular events in patients having noncardiac surgery, but it is unknown if the severity of preexisting coronary artery disease determines susceptibility to the cardiovascular risks of perioperative hypotension WHAT THIS ARTICLE TELLS US THAT IS NEW: In patients who had risk factors for, or known, coronary artery disease and were having noncardiac surgery, perioperative hypotension and degree of coronary artery disease on preoperative coronary computed tomographic angiography were independently associated with perioperative cardiovascular death and myocardial infarctionPerioperative hypotension was associated with cardiovascular events regardless of the degree of coronary artery disease on preoperative coronary computed tomographic angiography BACKGROUND:: Perioperative hypotension is associated with cardiovascular events in patients having noncardiac surgery. It is unknown if the severity of preexisting coronary artery disease determines susceptibility to the cardiovascular risks of perioperative hypotension.

Methods: In this retrospective exploratory analysis of a substudy of an international prospective blinded cohort study, 955 patients 45 yr of age or older with history or risk factors for coronary artery disease underwent coronary computed tomographic angiography before elective inpatient noncardiac surgery. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002654DOI Listing

Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.

Mol Psychiatry 2019 Mar 13. Epub 2019 Mar 13.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.

Higher scores on the personality trait of neuroticism, the tendency to experience negative emotions, are associated with worse mental and physical health. Studies examining links between neuroticism and health typically operationalize neuroticism by summing the items from a neuroticism scale. However, neuroticism is made up of multiple heterogeneous facets, each contributing to the effect of neuroticism as a whole. Read More

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http://dx.doi.org/10.1038/s41380-019-0387-3DOI Listing
March 2019
2 Reads

Coronary Artery Calcification and Mortality Risk in Patients With Severe Mental Illness.

Circ Cardiovasc Imaging 2019 Mar;12(3):e008236

Department of Clinical Medicine, Aalborg University, Denmark (M.B. Johansen, S.E.J.).

Background Cardiovascular mortality is the leading contributor to the shortened life expectancy in patients with severe mental illness (SMI), but efforts to predict cardiovascular outcomes in these patients have been lacking. In this study, we aimed to determine the severity of coronary artery calcification (CAC), and its effect on mortality rates in patients with SMI, compared with the general population. Methods All individuals with a registered cardiac computed tomography for calcium scoring in the Western Denmark Heart Registry, from January 1, 2008 to December 31, 2016, were included. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.118.0082
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http://dx.doi.org/10.1161/CIRCIMAGING.118.008236DOI Listing
March 2019
1 Read

Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer: A Review.

JAMA Cardiol 2019 Mar 13. Epub 2019 Mar 13.

Ted Rogers Program in Cardiotoxicity Prevention, Toronto General Hospital, Toronto, Ontario, Canada.

Importance: Clonal hematopoiesis (CH) has been recently described as a novel driver for cancer and cardiovascular disease (CVD). Clonal hematopoiesis is a common, age-associated disorder marked by expansion of hematopoietic clones carrying recurrent somatic mutations. Current literature suggests that patients with CH have a higher risk of subsequent hematological malignant conditions and mortality attributable to excess CVD. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.0302DOI Listing

Impact of long-term therapy with acetylsalicylic acid on immature platelet count: a single-centre cohort study.

J Cardiovasc Med (Hagerstown) 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiology, Ospedale 'Maggiore della Carità', Eastern Piedmont University, Novara.

: Acetylsalicylic acid (ASA) represents one of the most widely used pharmacological treatments for the prevention of atherothrombotic events. However, its use in low-risk patients is still debated, due to the complex balance between benefits and bleeding complications, therefore requiring new tools for the assessment of cardiovascular risk. Immature platelet count (IPC) has been suggested as a marker of platelet reactivity and turnover, thus potentially reflecting the progression of the chronic atherothrombotic vascular damage, which could be prevented by ASA. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000786DOI Listing

Effects of allopurinol and febuxostat on cardiovascular mortality in elderly heart failure patients.

Intern Emerg Med 2019 Mar 12. Epub 2019 Mar 12.

Internal Medicine Unit, S. Orsola-Malpighi University Hospital, Building 2 -IV Floor - Via Albertoni 15, 40138, Bologna, Italy.

Hyperuricemia is an emerging risk factor for the development of heart failure (HF) and is associated with a worsen prognosis of the disease. The effect of urate lowering drugs (ULT) and, in particular, the xanthine oxidase inhibitor in patients with HF is controversial. The aim of the study is to compare the effects of treatment with two different xanthine oxidase inhibitors (allopurinol or febuxostat) on cardiovascular mortality in elderly patients with chronic HF in a setting of clinical practice. Read More

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http://dx.doi.org/10.1007/s11739-019-02070-yDOI Listing
March 2019
4 Reads

Health-related quality of life one year after surgical treatment of the type I chronic aortic dissection.

Int Angiol 2019 Feb;38(1):46-53

E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian Federation, Novosibirsk, Russia.

Background: The purpose of our study was to assess the health-related quality of life (HRQoL) in patients with type I chronic aortic dissection before and one year after prosthetics of the aorta, and to test the hypothesis that long-term postoperative parameters of HRQoL are affected by clinical determinants related to the underlying disease, intraoperative characteristics, and complications of the early postoperative period.

Methods: This prospective cohort study included 82 patients with type I chronic aortic dissection. HRQoL parameters were examined using the Short-Form 36 Health Survey Questionnaire before and one year after surgery. Read More

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http://dx.doi.org/10.23736/S0392-9590.18.04009-9DOI Listing
February 2019

Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function.

Clin Res Cardiol 2019 Mar 11. Epub 2019 Mar 11.

2nd Department of Cardiology, Medical School, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Background: Anakinra, an interleukin-1 receptor antagonist and tocilizumab, an interleukin-6 receptor blocker, are used for the treatment of rheumatoid arthritis. We investigated the differential effects of anakinra and tocilizumab on myocardial and vascular function in an atherosclerosis model of patients with rheumatoid arthritis.

Methods: 120 patients with rheumatoid arthritis were randomized to anakinra (n = 40), tocilizumab (n = 40) or prednisolone (n = 40) for 3 months. Read More

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http://dx.doi.org/10.1007/s00392-019-01443-9DOI Listing

Epicardial fat volume measured on nongated chest CT is a predictor of coronary artery disease.

Eur Radiol 2019 Mar 11. Epub 2019 Mar 11.

Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Objective: To investigate whether epicardial fat volume (EFV) quantified on ECG-nongated noncontrast CT (nongated-NCCT) could be used as a reliable and reproducible predictor for coronary artery disease (CAD).

Methods: One hundred seventeen subjects (65 men, mean age 66.6 ± 11. Read More

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http://link.springer.com/10.1007/s00330-019-06079-x
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http://dx.doi.org/10.1007/s00330-019-06079-xDOI Listing
March 2019
4 Reads

The association between aspirin resistance and extent and severity of coronary atherosclerosis.

North Clin Istanb 2018 8;5(4):323-328. Epub 2018 Aug 8.

Department of Cardiology, Istanbul Bilim University Faculty of Medicine, Istanbul, Turkey.

Objective: Uncontrolled inflammatory responses could contribute to the pathogenesis of many leading causes of human morbidity and mortality. Aspirin is an anti-inflammatory and antithrombotic drug that is used in the primary and secondary protection in atherothrombotic diseases and complications. The aim of the present study was to analyze the effect of aspirin resistance on the extent and severity of atherosclerosis. Read More

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http://dx.doi.org/10.14744/nci.2017.26779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371993PMC

Bradyarrhythmia development and permanent pacemaker implantation after cardiac surgery.

North Clin Istanb 2018 8;5(4):288-294. Epub 2018 Aug 8.

Department of Cardiology, Health Science University Dr. Siyami Ersek Training and Research Hospital, Istanbul, Turkey.

Objective: Bradyarrhythmia is one of the complications that may develop after cardiac surgery. Only a few studies have previously dealt with this concern, and in our study, we investigated the factors affecting the development of atrioventricular block or sinus node dysfunction and the requirement of permanent pacemaker following cardiac surgery.

Methods: A total of 62 patients who developed the atrioventricular (AV) block or sinus node dysfunction and required a permanent pacemaker following cardiac surgery were included in the study. Read More

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http://dx.doi.org/10.14744/nci.2017.20438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371988PMC

Sex-related differences in frailty factors in older persons with type 2 diabetes: a cross-sectional study.

Ther Adv Endocrinol Metab 2019 5;10:2042018819833304. Epub 2019 Mar 5.

Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: This cross-sectional study aimed to describe sex-related differences in diabetes-specific factors underlying the development of frailty in older persons with type 2 diabetes.

Methods: Older persons aged 60-80 years were sequentially enrolled. Frailty and sarcopenia were evaluated using the validated Kihon checklist (KCL) and Asian Working Group for Sarcopenia algorithm, respectively. Read More

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http://dx.doi.org/10.1177/2042018819833304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402070PMC

Association of vitamin D deficiency and premature coronary artery disease.

Caspian J Intern Med 2019 ;10(1):80-85

Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Evidence suggests hypovitaminosis D is associated with increased risk of coronary artery disease (CAD) and its extent and related risk factors. However, some investigations have produced contrary results. Therefore, we aimed to evaluate the association between serum vitamin D levels and the severity of premature coronary artery involvement. Read More

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http://dx.doi.org/10.22088/cjim.10.1.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386332PMC
January 2019

Urinary Metabolites Altered during the Third Trimester in Pregnancies Complicated by Gestational Diabetes Mellitus: Relationship with Potential Upcoming Metabolic Disorders.

Int J Mol Sci 2019 Mar 8;20(5). Epub 2019 Mar 8.

Gynecology and Obstetrics Division, Hospital Central "Dr. Ignacio Morones Prieto",7800 San Luis Potosí, Mexico.

Gestational diabetes mellitus (GDM) is a disorder in pregnancy with highest impact in the future life of both mother and newborn. Increasing incidence, economic impact, and potential for severe GDM-related pregnancy complications are some factors that have motivated the deep study of physiopathology, risk factors for developing GDM, and potential biomarkers for its diagnosis. In the present pilot study, we analyzed the urinary metabolome profile of GDM patients in the 3rd trimester of pregnancy, when GDM is already established and the patients are under dietary and pharmacological control. Read More

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http://dx.doi.org/10.3390/ijms20051186DOI Listing
March 2019
2 Reads

[Local administration of vancomycin powder in posterior lumbar fusion surgery].

Khirurgiia (Mosk) 2019 (2):58-64

Irkutsk State Medical University, Irkutsk, Russia; Railway Clinical Hospital on the Irkutsk-Passazhirskiy station of Russian Railways Ltd., Irkutsk, Russia; Irkutsk Research Center of Surgery and Traumatology, Irkutsk, Russia.

Aim: To evaluate an efficacy of local administration of vancomycin powder in posterior lumbar fusion surgery for prevention of local infection.

Material And Methods: The study included 214 patients. All patients were divided into 2 groups: I group (control) and II (experimental). Read More

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http://www.mediasphera.ru/issues/khirurgiya-zhurnal-im-n-i-p
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http://dx.doi.org/10.17116/hirurgia201902158DOI Listing
January 2019
1 Read

The effects of vitamin D supplementation on glycemic control, lipid profiles and C-reactive protein among patients with cardiovascular disease: a systematic review and meta-analysis of randomized controlled trials.

Curr Pharm Des 2019 Mar 8. Epub 2019 Mar 8.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan. Iran.

Background: Insulin resistance, dyslipidemia and chronic inflammation are important risk factors for cardiovascular disease (CVD). Hence, vitamin D supplementation might be an appropriate approach to decrease the complications of CVD. This systematic review and meta-analysis aimed to determine the effects of vitamin D supplementation on glycemic control, lipid profiles, and C-reactive protein among patients with coronary artery disease. Read More

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http://dx.doi.org/10.2174/1381612825666190308152943DOI Listing
March 2019
1 Read

Genotypes of Common Polymorphisms in the PON1 Gene Associated With Paraoxonase Activity as Cardiovascular Risk Factor: A Cross-Sectional Study and Meta-Analysis of Studies Conducted in México.

Arch Med Res 2019 Mar 7. Epub 2019 Mar 7.

Laboratorio de Investigación en Epidemiología Clínica y Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, México. Electronic address:

Background: Paraoxonase-1(PON1) exhibits hydrolytic activity and prevents the oxidation of high and low-density lipoproteins. Polymorphisms in the PON1 gene have been associated with variations in paraoxonase activity and with the risk of coronary artery disease (CAD).

Aim Of The Study: This study analyzed the association between the frequencies of genotypes of the L55 M and Q192 R SNPs in the PON1 gene with the PON1 activity and with CAD risk factors. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.02.002DOI Listing

Social Factors, Sex, and Mortality Risk After Coronary Artery Bypass Grafting: A Population-Based Cohort Study.

J Am Heart Assoc 2019 Mar;8(6):e011490

1 Department of Molecular and Clinical Medicine Sahlgrenska Academy Gothenburg University Gothenburg Sweden.

Background Little is known of the impact of social factors on mortality after coronary artery bypass grafting ( CABG ). We explored sex- and age-specific associations between mortality risk after CABG and marital status, income, and education. Methods and Results This population-based register study included 110 742 CABG patients (21. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.011490
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http://dx.doi.org/10.1161/JAHA.118.011490DOI Listing
March 2019
1 Read

Knowledge gap of peripheral artery disease starts in medical school.

J Vasc Surg 2019 Mar 6. Epub 2019 Mar 6.

Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Division of Vascular Surgery, St. Michael's Hospital, Toronto, Ontario, Canada; The King Saud University-Li Ka Shing Collaborative Research Program, Riyadh, Saudi Arabia. Electronic address:

Objective: Previous data suggest that physicians have suboptimal knowledge about peripheral artery disease (PAD). Our aim was to evaluate Canadian medical students' knowledge of PAD to determine if this knowledge gap exists early in medical training.

Methods: We conducted a descriptive, cross-sectional, interview-based study of graduating medical students at the University of Toronto. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.12.042DOI Listing

Asymptomatic coronary artery disease in a Norwegian cohort with type 2 diabetes: a prospective angiographic study with intravascular ultrasound evaluation.

Cardiovasc Diabetol 2019 Mar 9;18(1):26. Epub 2019 Mar 9.

Department of Medical Research, Bærum Hospital Vestre Viken Hospital Trust, Gjettum, PB 800, 3004, Drammen, Norway.

Aims: The prevalence of asymptomatic coronary artery disease (CAD) in type 2 diabetes (T2D) is unclear. We investigated the extent and prevalence of asymptomatic CAD in T2D patients by utilizing invasive coronary angiography (ICA) and intravascular ultrasound (IVUS), and whether CAD progression, evaluated by ICA, could be modulated with a multi-intervention to reduce cardiovascular (CV) risk.

Methods: Fifty-six T2D patients with ≥ 1 additional CV risk factor participated in a 2 year randomized controlled study comparing hospital-based multi-intervention (multi, n = 30) versus standard care (stand, n = 26), with a pre-planned follow-up at year seven. Read More

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http://dx.doi.org/10.1186/s12933-019-0832-2DOI Listing
March 2019
1 Read

The Relationship between Coronary Artery Disease and Cardiovascular Events Early After Liver Transplantation.

Liver Int 2019 Mar 8. Epub 2019 Mar 8.

Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University VCU.

Cardiovascular complications are major contributors to mortality at liver transplantation(LT). However, the impact of coronary artery disease(CAD) on these complications is not well-understood as the literature is limited by non-invasive assessment of CAD, which is suboptimal in patients with cirrhosis. Thus, the current study evaluated cardiovascular events at LT stratified according to presence and severity of CAD quantified on coronary angiography. Read More

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http://dx.doi.org/10.1111/liv.14092DOI Listing
March 2019
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The immunometabolic role of indoleamine 2 3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall.

Cardiovasc Res 2019 Mar 7. Epub 2019 Mar 7.

Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.

Coronary heart disease (CHD) and stroke, the two most common cardiovascular diseases (CVDs) worldwide, are triggered by complications of atherosclerosis. Atherosclerotic plaques are triggered by a maladaptive immune response initiated by accumulation of lipids in the artery wall. Hence, disease is influenced by several non-modifiable and modifiable risk factors, including dyslipidaemia, hypertension, smoking, and diabetes. Read More

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http://dx.doi.org/10.1093/cvr/cvz067DOI Listing
March 2019
1 Read

Patient Radiation Dosage During Lower Extremity Endovascular Intervention.

JACC Cardiovasc Interv 2019 Mar;12(5):473-480

Division of Cardiovascular Medicine, Warren Alpert Medical School of Brown University and Lifespan Cardiovascular Institute, Providence, Rhode Island. Electronic address:

Objectives: The aims of this study were to determine the incidence of actionably high radiation dosages and to identify predictors of increased patient dosage.

Background: Peripheral endovascular intervention using fluoroscopic imaging has become a mainstay of treatment for lower extremity peripheral artery disease but exposes patients to ionizing radiation.

Methods: Patient radiation dosage, quantified as dose-area product (DAP), was obtained from the National Cardiovascular Data Registry Peripheral Vascular Intervention Registry. Read More

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http://dx.doi.org/10.1016/j.jcin.2018.11.005DOI Listing

Arterial stiffness is a predictor for acute kidney injury following coronary artery bypass graft surgery.

J Cardiothorac Surg 2019 Mar 7;14(1):51. Epub 2019 Mar 7.

Department of Renal Medicine, King's College Hospital, London, UK.

Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a serious postoperative complication of cardiac surgery, an episode of which impacts on patient morbidity and mortality. Pulse wave velocity (PWV; a non-invasive measurement tool to assess arterial stiffness) has been shown to predict kidney disease progression, and cardiovascular and all-cause mortality in patients with chronic kidney disease. We hypothesised that PWV would also predict acute kidney injury in subjects who have undergone non-valve repair elective coronary artery bypass graft (CABG) surgery . Read More

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http://dx.doi.org/10.1186/s13019-019-0873-3DOI Listing
March 2019
1 Read

Water Pipe (Hookah) Smoking and Cardiovascular Disease Risk: A Scientific Statement From the American Heart Association.

Circulation 2019 Mar 8:CIR0000000000000671. Epub 2019 Mar 8.

Tobacco smoking with a water pipe or hookah is increasing globally. There are millions of water pipe tobacco smokers worldwide, and in the United States, water pipe use is more common among youth and young adults than among adults. The spread of water pipe tobacco smoking has been abetted by the marketing of flavored tobacco, a social media environment that promotes water pipe smoking, and misperceptions about the addictive potential and potential adverse health effects of this form of tobacco use. Read More

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http://dx.doi.org/10.1161/CIR.0000000000000671DOI Listing

Calculated Serum Osmolality, Acute Kidney Injury, and Relationship to Mortality after Percutaneous Coronary Intervention.

Cardiorenal Med 2019 Mar 7;9(3):160-167. Epub 2019 Mar 7.

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York,

Background: Data on the associations between serum osmolality (sOsmo) and acute kidney injury (AKI) as well as short- and long-term mortality in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) are limited.

Objectives: To investigate the association between sOsmo and development of AKI and clinical outcomes in patients undergoing PCI.

Methods: We investigated 1,927 consecutive patients undergoing PCI from the registry of a single center. Read More

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http://dx.doi.org/10.1159/000494807DOI Listing
March 2019
2 Reads

Application of virtual histological intravascular ultrasound in plaque composition assessment of saphenous vein graft diseases.

Chin Med J (Engl) 2019 Feb 28. Epub 2019 Feb 28.

Department of Cardiology, Tianjin Chest Hospital, No. 261 Tai er zhuang Road, Jinnan District, Tianjin, 300222, P. R. China.

Objective: Saphenous vein grafts disease (SVGD) is a common complication after coronary artery bypass graft (CABG) and normally treated by percutaneous coronary intervention (PCI).The most common complication after SVG-PCI is slow or no-reflow. It is known that the no-reflow phenomenon occurs in up to 15% of the SVG-PCI and is associated with high risk of major adverse cardiac events (MACEs) and mortality, therefore it is important to investigate the factors that could predict the clinical outcome of PCI for risk stratification and guiding interventions. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000183DOI Listing
February 2019
1 Read

Sex Differences in Veterans' Cardiovascular Health.

J Womens Health (Larchmt) 2019 Mar 6. Epub 2019 Mar 6.

1 Department of Veterans Affairs, Central Office, Washington, District of Columbia.

Background: In the U.S. civilian population, sex differences have been identified in cardiovascular health; these differences have been used to inform care. Read More

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http://dx.doi.org/10.1089/jwh.2018.7228DOI Listing
March 2019
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Assessment of long-term survival and stroke after carotid endarterectomy and carotid stenting in patients older than 80 years.

J Vasc Surg 2019 Mar 2. Epub 2019 Mar 2.

First Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Italy; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.

Objective: The objective of this study was to analyze preoperative risk factors affecting long-term survival and the occurrence of stroke in patients older than 80 years undergoing either carotid endarterectomy (CEA) or carotid artery stenting (CAS) for carotid stenosis.

Methods: Data of all consecutive patients treated from January 1999 to December 2017 were retrospectively reviewed and outcomes analyzed. Kaplan-Meier analysis was used to estimate long-term survival and the risk of stroke for both groups. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.121DOI Listing
March 2019
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Relationship of exercise to coronary artery disease extent, severity and plaque type: A coronary computed tomography angiography study.

J Cardiovasc Comput Tomogr 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine III, Cardiology, Innsbruck Medical University, Austria. Electronic address:

Background: While exercise has been associated with favorable coronary artery disease (CAD) outcomes, the relationship between endurance exercise levels and CAD findings has not been well explored.

Purpose: To evaluate the relationship of endurance exercise to CAD findings by coronary computed tomographic angiography (CCTA).

Methods: We evaluated consecutive patients referred to CCTA who filled out a survey instrument between 2015 and 2017, and who graded their level of weekly endurance exercise as: none, low (1-2 times per week), moderate (3-5 times per week) or high (5-7 times per week); along with the number of hours per week engaged in exercise as: low (<30 min), moderate (1 h) or high (>1-3 h). Read More

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http://dx.doi.org/10.1016/j.jcct.2019.02.001DOI Listing
February 2019

Associations of Genetic Variations in and Lifestyle Factors with Coronary Artery Disease in a Southern Chinese Population with Dyslipidemia: A Nested Case-Control Study.

Int J Environ Res Public Health 2019 Mar 4;16(5). Epub 2019 Mar 4.

Medical School, Hangzhou Normal University, Hangzhou 310000, China.

Coronary artery disease has become a major health concern over the past several decades. We aimed to explore the association of single nucleotide polymorphisms (SNPs) in the ATP-binding cassette subfamily A member 1 () and lifestyle factors with coronary artery disease (CAD) in dyslipidemia. This nested case-control study included 173 patients with CAD and 500 matched control individuals (1:3, case: control) from a district in southern China. Read More

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http://dx.doi.org/10.3390/ijerph16050786DOI Listing
March 2019
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Myocardial bridges - occurrence and clinical presentations based on the Polish national ORPKI registry and CRCD classification.

Kardiol Pol 2019 Mar 5. Epub 2019 Mar 5.

Department of Interventional Cardiology, Jagiellonian University Medical College and John Paul II Hospital.

Background: A myocardial bridge (MB) is defined as a congenital anomaly, in which a segment of an epicardial coronary artery takes an intramuscular course.

Aim: To evaluate the prevalence of MB in coronary arteries among patients, who were diagnosed using coronarography.

Methods: The data were obtained from the National Polish Percutaneous Interventions Registry (ORPKI), among patients hospitalized between 01 January2014 and 31 December 2016 in invasive cardiology departments in Poland and divided into groups with and without MB. Read More

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http://dx.doi.org/10.5603/KP.a2019.0041DOI Listing
March 2019
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Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus.

Heart Vessels 2019 Mar 5. Epub 2019 Mar 5.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 7008558, Japan.

Coronary artery calcification (CAC) as measured by computed tomography is a strong predictor of coronary artery disease. The brachial intima-media thickness (IMT) was recently reported to be associated with cardiovascular risk factors. This study investigated the association of brachial IMT with CAC, which is a marker of coronary artery atherosclerosis, in patients with diabetes. Read More

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http://dx.doi.org/10.1007/s00380-019-01371-8DOI Listing
March 2019
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High levels of stromal cell-derived factor-1α predict short-term progression of renal dysfunction in patients with coronary artery disease.

Clin Exp Nephrol 2019 Mar 4. Epub 2019 Mar 4.

Department of Internal Medicine II, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, 409-3898, Japan.

Background: Stromal cell-derived factor-1α (SDF-1α) is an inflammatory chemokine that plays a critical role in cardiovascular disease. Although persistent inflammation causes renal dysfunction, it remains unclear whether SDF-1α is related to progression of chronic kidney disease. This study examined whether high levels of SDF-1α are associated with future declines in renal function in patients with coronary artery disease (CAD). Read More

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http://dx.doi.org/10.1007/s10157-019-01722-9DOI Listing
March 2019
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Characteristics of coronary artery disease in chronic kidney disease.

Clin Exp Nephrol 2019 Mar 4. Epub 2019 Mar 4.

Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Patients with chronic kidney disease (CKD) commonly experience cardiovascular disease (CVD), and a major cause of death in these patients is CVD. Therefore, the prevention of CVD progression is very crucial in patients with CKD. Recently, this relationship between CKD and CVD has increasingly been examined, and a concept termed "cardiorenal syndrome" has been advocated. Read More

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http://dx.doi.org/10.1007/s10157-019-01718-5DOI Listing
March 2019
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Arterial "inflammaging" drives vascular calcification in children on dialysis.

Kidney Int 2019 Feb 28. Epub 2019 Feb 28.

British Heart Foundation Centre of Excellence, Cardiovascular Division, King's College London, London, UK. Electronic address:

Children on dialysis have a cardiovascular mortality risk equivalent to older adults in the general population, and rapidly develop medial vascular calcification, an age-associated pathology. We hypothesized that premature vascular ageing contributes to calcification in children with advanced chronic kidney disease (CKD). Vessels from children with Stage 5 CKD with and without dialysis had evidence of increased oxidative DNA damage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193003
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http://dx.doi.org/10.1016/j.kint.2018.12.014DOI Listing
February 2019
5 Reads

Non-invasive measurements of arterial function: What? When? Why should we use them?

Heart 2019 Mar 2. Epub 2019 Mar 2.

Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1136/heartjnl-2018-312970DOI Listing

Presence of Calcium-Like Tissue Composition in Carotid Plaque is Indicative of Significant Coronary Artery Disease in High-Risk Patients.

J Am Soc Echocardiogr 2019 Feb 27. Epub 2019 Feb 27.

Department of Medicine, Cardiovascular Imaging Network at Queen's, Kingston Health Sciences Centre, Queen's University, Kingston, Ontario, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. Electronic address:

Background: Grayscale pixel ranges from ultrasound images, indicating differences in atherosclerotic plaque echogenicity, have been shown to represent different tissue types. Our objective was to determine whether carotid plaque composition was correlated with severity of coronary artery disease (CAD) and risk of cardiovascular (CV) events.

Methods: A focused carotid ultrasound was performed in 522 participants who had recently undergone coronary angiography. Read More

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http://dx.doi.org/10.1016/j.echo.2019.01.001DOI Listing
February 2019

Coronary Artery Disease Manifestations in HIV: What, How, and Why.

Can J Cardiol 2019 Mar 4;35(3):270-279. Epub 2018 Dec 4.

Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:

Understanding why persons with human immunodeficiency virus (HIV) have accelerated atherosclerosis and its sequelae, including coronary artery disease (CAD) and myocardial infarction, is necessary to provide appropriate care to a large and aging population with HIV. In this review, we delineate the diverse pathophysiologies underlying HIV-associated CAD and discuss how these are implicated in the clinical manifestations of CAD among persons with HIV. Several factors contribute to HIV-associated CAD, with chronic inflammation and immune activation likely representing the primary drivers. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.029DOI Listing

Left atrial appendage strain rate is associated with documented thromboembolism in nonvalvular atrial fibrillation.

Wien Klin Wochenschr 2019 Mar 1. Epub 2019 Mar 1.

East-Slovak Institute of Cardiovascular Diseases and Medical Faculty of Safarik University, Department of Cardiology, Safarik University, Ondavska 8, 040 11, Kosice, Slovakia.

Background: The left atrial appendage (LAA) strain and strain rate have not yet been studied in the prediction of cardiac thromboembolism. Therefore, this study aimed to evaluate the significance of LAA strain and strain rate as assessed by speckle-tracking imaging in relation to documented thromboembolic events.

Methods: A group of 80 patients with a mean age of 65 years who were referred for electrical cardioversion of nonvalvular atrial fibrillation was retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00508-019-1469-6DOI Listing
March 2019
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Interpretation of a coronary angiogram.

Heart 2019 Mar 1. Epub 2019 Mar 1.

Internal Medicine/Division of Cardiology, University of Southern California, Los Angeles, California, USA.

Clinical Introduction: A 42 year-old man with hypertension, hyperlipidaemia and tobacco abuse presented with typical chest pain. The pain was located in the substernal area, described as squeezing, non-radiating and awoke him from sleep. The pain was not associated with shortness of breath, abdominal pain, nausea and diaphoresis. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314213DOI Listing

Serum folate and vitamin B levels are not associated with the incidence risk of atherosclerotic events over 12 years: the Korean Genome and Epidemiology Study.

Nutr Res 2019 Mar 21;63:34-41. Epub 2018 Dec 21.

Department of Family Medicine, St Vincent's Hospital, college of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. Electronic address:

Atherosclerosis, a common cause of atherosclerotic vascular diseases, is associated with several risk factors including hyperhomocysteinemia, and vitamin B and folate are involved in homocysteine metabolism; thus, serum folate and vitamin B status may be associated with the risk of atherosclerotic vascular diseases mediated by homocysteine plasma concentrations. Therefore, we hypothesized that low vitamin B and folate levels are related to higher risks of atherosclerotic vascular disease and investigated the risk of atherosclerotic vascular events in Korean adults with low serum vitamin B and folate levels. This population-based cohort study followed 421 subjects aged 40-69 years for 12 years, 2003-2014. Read More

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http://dx.doi.org/10.1016/j.nutres.2018.12.009DOI Listing