48,879 results match your criteria Risk Factors for Coronary Artery Disease

Work-life conflict and cardiovascular health: 5-year follow-up of the Gutenberg Health Study.

PLoS One 2021 7;16(5):e0251260. Epub 2021 May 7.

Institute and Policlinic of Occupational and Social Medicine (IPAS), Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany.

Introduction: Work-life conflicts (WLC) may impact health, but few studies prospectively consider the impact of WLC on objective outcomes such as cardiovascular disease. Using data from the Gutenberg Health Study (GHS), we examined if WLC at baseline was associated with an increased five-year incidence of cardiovascular events (myocardial infarct, stroke, atrial fibrillation, peripheral artery disease, coronary artery disease, chronic heart failure, sudden cardiac death). We also considered if WLC was associated with incident hypertension and arterial stiffness and if the effects of WLC on cardiovascular health differ for men and women. Read More

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Calcification Prevalence in Different Vascular Zones and Its Association With Demographics, Risk Factors, and Morphometry.

Am J Physiol Heart Circ Physiol 2021 May 7. Epub 2021 May 7.

Department of Biomechanics, University of Nebraska Omaha, Omaha, NE, United Statesgrid.266815.e.

Vascular calcification is associated with a higher incidence of cardiovascular events, but its prevalence in different vascular zones and the influence of demographics, risk factors, and morphometry remain insufficiently understood. Computerized Tomography Angiography scans from 211 subjects 5-93 years old (mean age 47±24 years, 127M/84F) were used to build 3D vascular reconstructions and measure arterial diameters, tortuosity, and calcification volumes in six vascular zones spanning from the ascending thoracic aorta to the pelvic arteries. A machine learning random forest algorithm was used to determine the associations between calcification in each zone with demographics, risk factors, and vascular morphometry. Read More

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Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis.

Am J Physiol Heart Circ Physiol 2021 May 7. Epub 2021 May 7.

Department of Physiology and Pharmacology and Michael E. DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, United Statesgrid.264756.4.

Until recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease and clinical interventions have been dedicated primarily to identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the co-existence of macro- and microvascular disease, and how the structure and function of the distal microcirculation is impacted by the hemodynamic consequences of an epicardial, flow-limiting stenosis. Read More

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The catabolic triad: case report of fasting, major cardiac surgery and sodium-glucose co-transporter 2 inhibitors leading to perioperative euglycaemic ketoacidosis.

Interact Cardiovasc Thorac Surg 2021 May 7. Epub 2021 May 7.

Blackrock Clinic, Dublin, Ireland.

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are novel oral hypoglycaemic agents. For patients with diabetes mellitus, without a prior history of myocardial infarction or atherosclerotic disease, SGLT2i have been shown to reduce incident heart failure and worsening renal function. SGLT2i therapy is increasing among patients presenting for cardiac surgery. Read More

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National Heart Foundation of Australia: position statement on coronary artery calcium scoring for the primary prevention of cardiovascular disease in Australia.

Med J Aust 2021 May 7. Epub 2021 May 7.

National Heart Foundation of Australia, Melbourne, VIC.

Introduction: This position statement considers the evolving evidence on the use of coronary artery calcium scoring (CAC) for defining cardiovascular risk in the context of Australian practice and provides advice to health professionals regarding the use of CAC scoring in primary prevention of cardiovascular disease in Australia. Main recommendations: CAC scoring could be considered for selected people with moderate absolute cardiovascular risk, as assessed by the National Vascular Disease Prevention Alliance (NVDPA) absolute cardiovascular risk algorithm, and for whom the findings are likely to influence the intensity of risk management. (GRADE evidence certainty: Low. Read More

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Relationship Between Fasting Glucose, HbA Levels, and the SYNTAX Score 2 in Patients With Non-ST-Elevation Myocardial Infarction.

Angiology 2021 May 7:33197211014678. Epub 2021 May 7.

Department of Cardiology, 52979Koc University Hospital, Istanbul, Turkey.

We evaluated if admission glycosylated hemoglobin (HbA) and fasting glucose levels are correlated with the severity of coronary artery disease (CAD) in non-ST-elevation myocardial infarction (NSTEMI), nondiabetic, patients. Coronary artery disease severity, according to the anatomical synergy between percutaneous coronary intervention (PCI) with taxus and cardiac surgery (SYNTAX) score 2 (SSII), was retrospectively evaluated in 359 nondiabetic patients hospitalized with NSTEMI who underwent coronary angiography. Glucose intolerance was assessed by serum fasting glucose and HbA levels. Read More

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The Predictive Value of Myeloperoxidase for Contrast-Induced Nephropathy After Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction.

Int J Gen Med 2021 30;14:1621-1629. Epub 2021 Apr 30.

Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing, 210009, People's Republic of China.

Background: Higher serum myeloperoxidase (MPO) in patients with acute coronary syndrome is associated with adverse cardiovascular outcomes. Contrast-induced nephropathy (CIN) is associated with worse prognosis in patients with coronary artery disease following angiography. We have no idea whether patients with higher serum myeloperoxidase have a higher risk of CIN in acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Read More

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The Impact of a Population-based Prevention Program on Cardiovascular Events: Findings from the Heart of New Ulm Project.

Am Heart J 2021 May 3. Epub 2021 May 3.

Minneapolis Heart Institute Foundation, 920 East 28th Street, Suite 100, Minneapolis, MN; Minneapolis Heart Institute, 920 East 28th Street, Suite 300, Minneapolis, MN.

Background: Cardiovascular disease (CVD) and its associated risk factors are the principal drivers of mortality and healthcare costs in the United States with rural residents experiencing higher CVD death rates than their urban counterparts.

Methods: The purpose of this study was to examine incidence of major CVD events over 9 years of implementation of the Heart of New Ulm (HONU) Project, a rural population-based CVD prevention initiative. HONU interventions were delivered at individual, organizational, and community levels addressing clinical risk factors, lifestyle behaviors and environmental changes. Read More

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Identification of Risk of Cardiovascular Disease by Automatic Quantification of Coronary Artery Calcifications on Radiotherapy Planning CT Scans in Patients With Breast Cancer.

JAMA Oncol 2021 May 6. Epub 2021 May 6.

Division of Imaging and Oncology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.

Importance: Cardiovascular disease (CVD) is common in patients treated for breast cancer, especially in patients treated with systemic treatment and radiotherapy and in those with preexisting CVD risk factors. Coronary artery calcium (CAC), a strong independent CVD risk factor, can be automatically quantified on radiotherapy planning computed tomography (CT) scans and may help identify patients at increased CVD risk.

Objective: To evaluate the association of CAC with CVD and coronary artery disease (CAD) in patients with breast cancer. Read More

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Interpreting Coronary Artery Disease Risk Through Gene-Environment Interactions in Gene Regulation.

Genetics 2019 Oct;213(2):651-663

Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48201.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Epidemiological and genome-wide association studies have identified environmental and genetic risk factors for CVD. Using human vascular endothelial cells treated with dexamethasone, retinoic acid, caffeine, and selenium. Read More

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October 2019

Interpreting Coronary Artery Disease Risk Through Gene-Environment Interactions in Gene Regulation.

Genetics 2019 Oct;213(2):651-663

Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan 48201.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Epidemiological and genome-wide association studies have identified environmental and genetic risk factors for CVD. Using human vascular endothelial cells treated with dexamethasone, retinoic acid, caffeine, and selenium. Read More

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October 2019

Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation: A retrospective, single center study.

World J Transplant 2021 Apr;11(4):114-128

Department of Anesthesiology, University of Miami/Jackson Memorial Hospital, Miami, FL 33136, United States.

Background: There is an abundant need to increase the availability of deceased donor kidney transplantation (DDKT) to address the high incidence of kidney failure. Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients; thus the identification of modifiable risk factors associated with poor outcomes is paramount.

Aim: To identify risk factors associated with delayed graft function (DGF). Read More

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Epicardial Adipose Tissue Volume Is Associated with High Risk Plaque Profiles in Suspect CAD Patients.

Oxid Med Cell Longev 2021 12;2021:6663948. Epub 2021 Apr 12.

Department of Cardiovascular Medicine, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

Objective: To explore the association between EAT volume and plaque precise composition and high risk plaque detected by coronary computed tomography angiography (CCTA).

Methods: 101 patients with suspected coronary artery disease (CAD) underwent CCTA examination from March to July 2019 were enrolled, including 70 cases acute coronary syndrome (ACS) and 31 cases stable angina pectoris (SAP). Based on CCTA image, atherosclerotic plaque precise compositions were analyzed using dedicated quantitative software. Read More

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Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Vascular and Endovascular Surgery Unit, Department of Surgery, "Sapienza" University of Rome, Rome, Italy.

Introduction: Carotid artery stenting (CAS) has become a valid alternative to carotid endarterectomy in stroke prevention. However, female gender is still considered as an independent risk factor for CAS procedures, potentially limiting immediate and long-term benefits. Aim of present study was to evaluate gender differences in CAS submitted patients from an Italian high-volume center. Read More

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A prospective observational study of preoperative natriuretic peptide testing in adult non-cardiac surgical patients in hospitals in Western Cape Province, South Africa.

S Afr Med J 2021 03 31;111(4):338-342. Epub 2021 Mar 31.

Department of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, South Africa.

Background: International guidelines recommend risk stratification to identify high-risk non-cardiac surgical patients. It is also recommended that all patients aged ≥45 years with significant cardiovascular disease should have preoperative natriuretic peptide (NP) testing. Abnormal preoperative B-type NPs have a strong association with postoperative cardiac complications. Read More

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Role of dyslipidemia in ischemic stroke patients treated in the telestroke network.

Adv Med Sci 2021 Apr 30;66(2):254-261. Epub 2021 Apr 30.

University of South Carolina, School of Medicine-Greenville, 607 Grove Rd, Greenville, SC, USA. Electronic address:

Purpose: The relationship between the telestroke technology and clinical risk factors in a dysplipidemic ischemic stroke population and neurologic outcomes is not fully understood. This issue was investigated in this study.

Patients And Methods: We analyzed retrospective data collected from a regional stroke registry to identify demographic and clinical risk factors in patients with improving (NIHSS ​≤ ​7) or worsening (NIHSS ​> ​7) neurologic outcome in dyslipidemic ischemic stroke population. Read More

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Post hoc assessment of relationship between coronary stenosis, ECG and ventricular function in patients with heart disease.

Can J Physiol Pharmacol 2021 May 3. Epub 2021 May 3.

USF Health Morsani College of Medicine, 33697, Tampa, Florida, United States;

Cardiovascular diseases including cardiac arrhythmias lead to fatal events in patients with coronary artery disease, however clinical associations from echocardiography, electrocardiography (ECG) and biomarkers remain unknown. We sought to identify the factors that may be related to elevated QRS intervals in patients with risk for coronary artery disease. In this study, we performed analysis of clinical data from 503 patients and divided into two groups, i. Read More

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Smoking behavior after coronary artery bypass surgery: Quit, relapse, continuing.

Ann Card Anaesth 2021 Jan-Mar;24(1):56-61

Department of Cardiac Surgery, Papanikolaou General Hospital, Thessaloniki, Greece.

Objective: Tobacco smoking represents a major risk factor for coronary artery disease. Our study aimed to investigate whether Coronary Artery Bypass Graft (CABG) surgery could act as a motivating factor to enforce smoking cessation. Specifically, we observed the success rate in individuals who quitted smoking, along with the number and reasons of relapse(s) at least one year after the operation. Read More

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Postangioplasty aneurysm of right coronary artery.

J Card Surg 2021 May 3. Epub 2021 May 3.

Department of Cardiac Surgery, Ospedale Santa Maria della Misericordia, Azienda Ospedaliera di Perugia, Perugia, Italy.

Background: Coronary artery aneurysms are an uncommon disease whose incidence ranges from 0.3% to 5.3%. Read More

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Adverse Childhood Experiences and the Risk of Coronary Heart Disease in Adulthood: Examining Potential Psychological, Biological, and Behavioral Mediators in the Whitehall II Cohort Study.

J Am Heart Assoc 2021 May 3:e019013. Epub 2021 May 3.

Department of Psychiatry McGill University Montreal Canada.

Background This study investigated potential psycho-bio-behavioral mediators of the association between adverse childhood experiences (ACEs) and the risk of coronary heart disease (CHD) in adulthood. Methods and Results Participants were 5610 British civil servants (mean age, 55.5; 28% women) from the Whitehall II cohort study without CHD at baseline in 1997 to 1999 (wave 5) when retrospective data on the number of ACEs were collected via questionnaire (range, 0-8). Read More

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Clinical review of COVID-19 patients presenting to a quaternary care private hospital in South India: A retrospective study.

Clin Epidemiol Glob Health 2021 Jul-Sep;11:100751. Epub 2021 Apr 26.

MIOT International Hospital, Chennai, Tamil Nadu, 600089, India.

Background: Coronavirus disease 2019 (COVID-19) has been declared a global public-health crisis due to its impact on health, economy, and mental well-being. Here, we evaluated the clinical and epidemiological parameters associated with COVID-19 in South India.

Methods: A retrospective, quaternary care hospital-based study that included COVID-19 positive patients admitted to MIOT International Hospital, Chennai between 8 April-7 August 2020. Read More

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An Update on Cardiovascular Risk Factors After Kawasaki Disease.

Front Cardiovasc Med 2021 16;8:671198. Epub 2021 Apr 16.

Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.

First described in Japan 50 years ago, Kawasaki disease is a worldwide multisystem disease. It is an acute self-limited vasculitis of unknown etiology that can lead to coronary artery lesions, such as dilatation, aneurysms, and stenosis in children. It is one of the common causes of acquired heart disease among children in developed countries. Read More

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Sortilin as a Biomarker for Cardiovascular Disease Revisited.

Front Cardiovasc Med 2021 16;8:652584. Epub 2021 Apr 16.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Genetic variants in the genomic region containing (encoding the protein sortilin) are strongly associated with cholesterol levels and the risk of coronary artery disease (CAD). Circulating sortilin has therefore been proposed as a potential biomarker for cardiovascular disease. Multiple studies have reported association between plasma sortilin levels and cardiovascular outcomes. Read More

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Low-Density Lipoprotein Cholesterol 4: The Notable Risk Factor of Coronary Artery Disease Development.

Front Cardiovasc Med 2021 16;8:619386. Epub 2021 Apr 16.

Department of Cardiovascular Medicine, The First People's Hospital of Pingdingshan, Pingdingshan, China.

Coronary artery disease (CAD) is the leading cause of death worldwide, which has a long asymptomatic period of atherosclerosis. Thus, it is crucial to develop efficient strategies or biomarkers to assess the risk of CAD in asymptomatic individuals. A total of 356 consecutive CAD patients and 164 non-CAD controls diagnosed using coronary angiography were recruited. Read More

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Comprehensive Metabolomics Identified the Prominent Role of Glycerophospholipid Metabolism in Coronary Artery Disease Progression.

Front Mol Biosci 2021 14;8:632950. Epub 2021 Apr 14.

Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China.

Coronary stenosis severity determines ischemic symptoms and adverse outcomes. The metabolomic analysis of human fluids can provide an insight into the pathogenesis of complex disease. Thus, this study aims to investigate the metabolomic and lipidomic biomarkers of coronary artery disease (CAD) severity and to develop diagnostic models for distinguishing individuals at an increased risk of atherosclerotic burden and plaque instability. Read More

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Predictors and Outcomes of Coronary Artery Bypass Grafting: A Systematic and Untargeted Analysis of More Than 120,000 Individuals and 1,300 Disease Traits.

J Cardiothorac Vasc Anesth 2021 Mar 27. Epub 2021 Mar 27.

Department of Internal Medicine, Turku University Hospital and University of Turku, Turku, Finland; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.

Objective: To perform an untargeted data-driven analysis on the correlates and outcomes of coronary artery bypass grafting (CABG).

Design: FinnGen cohort study.

Setting: The authors collected information on up to 1,327 disease traits before and after CABG from nationwide healthcare registers. Read More

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Smoking and obesity predict high-risk plaque by coronary CTA in low coronary artery calcium score (CACS).

J Cardiovasc Comput Tomogr 2021 Apr 24. Epub 2021 Apr 24.

Department of Radiology, Innsbruck Medical University, Austria. Electronic address:

Background: The AHA recommends statins in patients with CACS>100 AU. However in patients with low CACS (1-99 AU), no clear statement is provided, leaving the clinician in a grey-zone. High-risk plaque (HRP) criteria by coronary CTA are novel imaging biomarkers indicating a higher a-priori cardiovascular (CV) risk, which could help for decision-making. Read More

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Endurance exercise and the risk of cardiovascular pathology in men: a comparison between lifelong and late-onset endurance training and a non-athletic lifestyle - rationale and design of the Master@Heart study, a prospective cohort trial.

BMJ Open Sport Exerc Med 2021 16;7(2):e001048. Epub 2021 Apr 16.

Cardiovascular Sciences, KU Leuven University Hospitals Leuven, Leuven, Flanders, Belgium.

Introduction: Low and moderate endurance exercise is associated with better control of cardiovascular risk factors, a decreased risk of coronary artery disease and atrial fibrillation (AF). There is, however, a growing proportion of individuals regularly performing strenuous and prolonged endurance exercise in which the health benefits have been challenged. Higher doses of endurance exercise have been associated with a greater coronary atherosclerotic plaque burden, risk of AF and myocardial fibrosis (MF). Read More

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Acute cardiovascular syndrome in the Italian multiethnic society.

J Cardiovasc Med (Hagerstown) 2021 Apr 28. Epub 2021 Apr 28.

Cardiac Intensive Care Unit and De Gasperis Cardio Center Cardiology IV and De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda School of Emergency Medicine School of Medicine and Surgery, Università degli Studi Milano-Bicocca, Milan, Italy.

Background: In multiethnic societies, it has frequently and repeatedly been shown that some minority groups have higher rates of traditional coronary artery disease (CAD) risk factors, different rates of treatment with revascularization procedures, and excess morbidity and mortality from CAD when compared with the white population. In the last two decades, Italy is becoming a diverse society with more than five millions of inhabitants from minority ethnic groups: for this reason, we decided to investigate whether ethnic differences in our metropolitan area are similar compared with the experience of Western countries.

Methods And Results: We performed a retrospective cohort study of 1285 patients with acute coronary syndromes (ACS) hospitalized at Intensive Cardiac Care Unit (ICCU), Heart Center of ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy between 2014 and the end of 2019. Read More

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Effect of lipoprotein on coronary stents expansion and its risk factors.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar;46(3):249-256

Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Objectives: To analyze the effect of hyperlipoproteinemia (α) on immediate expansion after coronary stent implantation guided by intravascular ultrasound (IVUS).

Methods: A total of 160 patients (175 lesions) with coronary heart disease diagnosed by coronary artery angiography, who were performed percutaneous intervention guided by IVUS in the Department of Cardiology, Third Xiangya Hospital, Central South University, were enrolled retrospectively.According to the concentration of lipoproteina, the patients were divided into 2 groups: a hyperlipoproteinemia (α) group and a control group. Read More

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