52,487 results match your criteria Risk Factors for Coronary Artery Disease


Serum uric acid in patients with ST-segment elevation myocardial infarction: An innocent bystander or leading actor?

Nutr Metab Cardiovasc Dis 2022 Apr 4. Epub 2022 Apr 4.

Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

Elevated serum uric acid (SUA) levels have been associated with several cardiovascular risk factors and the progression of coronary artery disease. In the setting of acute myocardial infarction, increasing evidence suggests that high SUA levels could be related to adverse outcomes. Interestingly elevated SUA levels have been linked to endothelial dysfunction, inflammation and oxidative stress. Read More

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Association between gastroesophageal reflux disease and coronary atherosclerosis.

PLoS One 2022 20;17(5):e0267053. Epub 2022 May 20.

Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.

Background And Aim: Gastroesophageal reflux disease (GERD) typically presents with symptoms of heartburn and acid regurgitation but occasionally manifests as atypical chest pain. Coronary artery disease (CAD) and GERD share some risk factors, such as smoking and obesity. The aims of this study were to evaluate the association between GERD and coronary atherosclerosis and to assess the risk factors for coronary atherosclerosis in GERD patients. Read More

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Major adverse cardiovascular events in bulgarian patients with chronic coronary syndrome.

Niger J Clin Pract 2022 May;25(5):710-717

Department of Cardiology, Medical University, University Hospital Alexandrovska, Clinic of Propedeutics of Internal Diseases, Sofia, Bulgaria.

Background: In primary prevention, most guidelines rely on atherosclerotic cardiovascular disease risk assessment to determine the appropriateness and intensity of risk factor modification.

Aims: This study aimed to analyze the prognostic role of risk factors, comorbidities, and coronary artery calcium score (CACS) for major adverse cardiovascular events (MACEs) in Bulgarian patients with chronic coronary syndrome. An observational study conducted in a cardiology department. Read More

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Prevalence of Cardiovascular Risk Factors and 10-Years Risk for Coronary Heart Disease in the United Arab Emirates.

Curr Diabetes Rev 2022 Apr 21. Epub 2022 Apr 21.

Department of Medicine, Weill Cornell Medical College, New York, USA.

Background: In the United Arab Emirates (UAE), cardiovascular diseases (CVDs) are the leading cause of mortality, and the incidence of premature coronary heart diseases (CHDs) is about 10-15 years earlier than the people in western countries.

Aim: The current cross-sectional study aims to describe the prevalence of CVDs risk factors and estimate the 10-years risk for CHDs in the population of Abu Dhabi Emirate in the UAE.

Objective: The main objective was to report the 10-years risk for CHDs in a sample of the UAE population. Read More

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Left main coronary artery vasospasm: A case report of misdiagnosed severe coronary artery disease.

Ann Med Surg (Lond) 2022 Jun 29;78:103691. Epub 2022 Apr 29.

Department of Medicine, Division of Cardiology, Creighton University School of Medicine, Omaha, NE, USA.

Introduction And Importance: Left main coronary artery (LMCA) vasospasm is rare and can cause demand-supply mismatch that can mimic coronary artery disease (CAD). This could lead to misdiagnosis and inappropriate referral for surgical intervention.

Case Presentation: A 55-year-old woman with no cardiac risk factors presented with anginal chest pain. Read More

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Diabetic Retinopathy as a Predictor of Angiographic Coronary Atherosclerosis Severity in Patients with Type 2 Diabetes Mellitus.

Diabetes Metab Syndr Obes 2022 11;15:1485-1494. Epub 2022 May 11.

Department of Internal Medicine, Sohag University Hospital, Sohag University, Sohag, Egypt.

Background: Diabetic retinopathy (DR) is one of the most prevalent consequences of diabetes mellitus (DM). Much emphasis has been focused on the link between DR and cardiovascular disorders in patients with type 2 diabetes (T2DM). However, there is little information about the relation between the degree of DR and coronary atherosclerosis severity in Egyptian patients. Read More

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Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk.

Nat Genet 2022 May 19. Epub 2022 May 19.

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across cell types. Genome-wide association studies have identified over 200 loci associated with CAD, where the majority of risk variants reside in noncoding DNA sequences impacting cis-regulatory elements. Here, we applied single-nucleus assay for transposase-accessible chromatin with sequencing to profile 28,316 nuclei across coronary artery segments from 41 patients with varying stages of CAD, which revealed 14 distinct cellular clusters. Read More

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Perioperative outcomes and readmissions following cardiac operations in kidney transplant recipients.

Heart 2022 May 19. Epub 2022 May 19.

Cardiovascular Outcomes Research Laboratories (CORELAB), Division of Cardiac Surgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA

Objective: Although kidney transplant (KTx) recipients are at significant risk for cardiovascular disease, outcomes following cardiac operations have been examined in limited series. The present study thus aimed to assess the impact of KTx on in-hospital perioperative outcomes and readmissions in a nationally representative cohort.

Methods: All adults undergoing elective coronary artery bypass grafting, valve repair/replacement or a combination thereof were identified from the 2010-2018 Nationwide Readmissions Database. Read More

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Racial Disparities in the Risk for Thromboembolic Events in COVID-19 Patients during the Height of the SARS-CoV-2 Pandemic and Impact on Outcomes.

Ann Vasc Surg 2022 May 16. Epub 2022 May 16.

Loyola University Medical Center, Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, 2160 S. First Avenue, EMS 110 Room 3215, Maywood, IL, USA, 60153. Electronic address:

Objective: The primary objective of this study is to assess the risk of thromboembolic events in hospitalized patients with COVID-19 and study the impact of thromboembolic events on hospital course and mortality risk during the initial height of the SARS-CoV-2 pandemic.

Methods: A retrospective review of all adult inpatients (≥18 years old) with COVID-19 infection at a single academic institution from March 15, 2020 - July 1, 2020 was performed. Collected data included patient demographics, comorbidities, hospital admission type, thromboembolic events, laboratory values, use of anticoagulants/antiplatelet agents, hospital length of stay, and in-hospital mortality. Read More

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Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities.

Front Cardiovasc Med 2022 2;9:895053. Epub 2022 May 2.

Cardiology Unit, DICATOV - Cardiothoracic and Vascular Department, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, Genoa, Italy.

Myocardial infarction with non-obstructive coronary arteries (MINOCA), despite a lower burden of coronary atherosclerosis, has a non-negligible prognostic impact. The label of MINOCA includes an array of different aetiologies and pathologic conditions, thus the identification of the underlying disease is crucial to patient management. Myocardial infarction with obstructive coronary artery disease and MINOCA share only some risk factors and comorbid conditions. Read More

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Sleep Apnea and Risk of Influenza-Associated Severe Acute Respiratory Infection: Real-World Evidence.

Nat Sci Sleep 2022 10;14:901-909. Epub 2022 May 10.

Faculty of Medicine, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.

Purpose: We executed the presented retrospective cohort study with the purpose of probing the risk of severe acute respiratory infection (SARI) following influenza in patients with sleep apnea.

Materials And Methods: We executed this real-world study by gathering Taiwan National Health Insurance Research Database (NHIRD) data. From a database containing 1 million individuals sampled at random from the NHIRD, we identified all patients aged 20 years or older with a sleep apnea diagnosis between 1997 and 2013 as the study group. Read More

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Radiation-induced coronary artery disease: a difficult clinical conundrum.

Clin Med (Lond) 2022 May;22(3):251-256

Royal Free Hospital, London, UK.

Accelerated coronary artery disease seen following radiation exposure is termed 'radiation-induced coronary artery disease' (RICAD) and results from both the direct and indirect effects of radiation exposure. Long-term data are available from survivors of nuclear explosions and accidents, nuclear workers as well as from radiotherapy patients. The last group is, by far, the biggest cause of RICAD presentation. Read More

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Incidental chest findings on coronary CT angiography: a pictorial essay and management proposal.

J Bras Pneumol 2022 13;48(4):e20220015. Epub 2022 May 13.

. Imaging Department, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, United Kingdom.

Many health systems have been using coronary CT angiography (CCTA) as a first-line examination for ischaemic heart disease patients in various countries. The rising number of CCTA examinations has led to a significant increase in the number of reported incidental extracardiac findings, mainly in the chest. Pulmonary nodules are the most common incidental findings on CCTA scans, as there is a substantial overlap of risk factors between the population seeking to exclude ischaemic heart disease and those at risk of developing lung cancer (i. Read More

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A novel predictor in patients with coronary chronic total occlusion: systemic immune-inflammation index: a single-center cross-sectional study.

Rev Assoc Med Bras (1992) 2022 May;68(5):579-585

Dicle University, School of Medicine, Department of Cardiology - Diyarbakır, Turkey.

Objective: Severe inflammation is reportedly associated with subsequent cardiovascular events, including in patients with coronary artery disease. This study aimed to examine the prognostic value of systemic immune-inflammation index and determine mortality and clinical outcomes in patients with chronic coronary total occlusion.

Methods: Our study evaluated 366 consecutive coronary total occlusion patients. Read More

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Genetic liability to rheumatoid arthritis in relation to coronary artery disease and stroke risk.

Arthritis Rheumatol 2022 May 18. Epub 2022 May 18.

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Objectives: To assess the causality of the associations of rheumatoid arthritis (RA) with coronary artery disease (CAD) and stroke using Mendelian randomization approach.

Methods: Independent single nucleotide polymorphisms strongly associated with RA (n=70) were selected as instrumental variables from a genome-wide association meta-analysis including 14,361 RA cases and 43,923 controls of European ancestry. Summary-level data for CAD, all stroke, any ischemic stroke and its subtypes, intracerebral hemorrhage, and subarachnoid hemorrhage were obtained from meta-analyses of genetic studies, international genetic consortia, the UK Biobank, and the FinnGen consortium. Read More

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Rare and Common Genetic Variation Underlying the Risk of Hypertrophic Cardiomyopathy in a National Biobank.

JAMA Cardiol 2022 May 18. Epub 2022 May 18.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Importance: Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death in young people. Although rare genetic variants are well-established contributors to HCM risk, common genetic variants have recently been implicated in disease pathogenesis.

Objective: To assess the contributions of rare and common genetic variation to risk of HCM in the general population. Read More

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Association Between High-Density Lipoprotein Cholesterol Levels and Adverse Cardiovascular Outcomes in High-risk Populations.

JAMA Cardiol 2022 May 18. Epub 2022 May 18.

Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

Importance: Previous studies have shown lower cardiovascular risk with higher high-density lipoprotein cholesterol (HDL-C) levels. However, recent data in the general population have shown increased risk of adverse outcomes at very high HDL-C concentrations.

Objective: To study the association between very high HDL-C levels (>80 mg/dL) and mortality in patients with coronary artery disease (CAD) and to investigate the association of known HDL-C genotypes with high HDL-C level outcomes. Read More

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Impact of Coronary Artery Anatomy in Arterial Switch Operation: In-hospital and Post-discharge Outcomes.

Curr Med Sci 2022 May 17. Epub 2022 May 17.

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objective: The influence of the coronary artery anatomy on the prognosis of patients receiving an arterial switch operation (ASO) is currently controversial, and the risk factors for this operation may change in more complicated patients. This study aimed to investigate the influence of coronary artery anomalies on the in-hospital and post-discharge outcomes of ASO in patients with transposition of the great arteries (TGA) and Taussig-Bing anomaly (TBA).

Methods: We retrospectively reviewed 206 patients who underwent ASO from January 2007 to December 2019. Read More

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A five-parameter score for predicting saphenous vein graft degenerative and/or occlusive disease in recurring ischemic symptoms after one year post coronary artery bypass grafting.

Perfusion 2022 May 18:2676591221090588. Epub 2022 May 18.

Tianjin Medical University, Tianjin, China.

Background: The recurrence rate of ischemic symptoms after coronary artery bypass grafting (CABG) is increasing in recent years. How to prevent and treat saphenous vein graft disease (SVGD [symptomatic ⩾50% stenosis in at least one Saphenous vein graft]) has been a clinical challenge to date. Different pathogenesis may exist in SVGD of different periods. Read More

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Foot Osteomyelitis Location and Rates of Primary or Secondary Major Amputations in Patients With Diabetes.

Foot Ankle Int 2022 May 18:10711007221088552. Epub 2022 May 18.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Background: Diabetic foot osteomyelitis (DFO) often leads to amputations in the lower extremity. Data on the influence of the initial anatomical DFO localization on ultimate major amputation are limited.

Methods: In this retrospective analysis, 583 amputation episodes in 344 patients (78 females, 266 males) were analyzed. Read More

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ST-elevation myocardial infarction in a young patient with Duchenne's muscular dystrophy: a case report.

Eur Heart J Case Rep 2022 May 16;6(5):ytac184. Epub 2022 May 16.

Cardiology Department, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.

Background: Duchenne's muscular dystrophy (DMD) is an X-linked muscular disease which is caused by the absence of dystrophin. This results in the death of muscle cells and cardiomyocytes and consequent substitution by fat and fibrous tissue. The clinical translation of this is muscle weakness and cardiomyopathy. Read More

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Prophylactic Mechanical Circulatory Support Use in Elective Percutaneous Coronary Intervention for Patients With Stable Coronary Artery Disease.

Circ Cardiovasc Interv 2022 May 17;15(5):e011534. Epub 2022 May 17.

Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (M.Z., G.M.G., P.Z., D.M.W., S.V.R., T.Y.W.).

Background: Mechanical circulatory support (MCS) devices can be used in high-risk percutaneous coronary intervention (PCI). Our objective was to describe trends and outcomes of prophylactic MCS use in elective PCI for patients with stable coronary artery disease in the American College of Cardiology National Cardiovascular Data Registry's CathPCI registry.

Methods: Among 2 108 715 consecutive patients with stable coronary artery disease undergoing elective PCI in the CathPCI registry between 2009 and 2018, we examined patterns of prophylactic use of MCS. Read More

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Suboptimal HIV suppression is associated with progression of coronary artery stenosis: The Multicenter AIDS Cohort Study (MACS) longitudinal coronary CT angiography study.

Atherosclerosis 2022 Apr 25. Epub 2022 Apr 25.

The Lundquist Institute at Harbor-UCLA Medical Center, 1124 W Carson Street, Torrance, CA, 90502, USA.

Background And Aims: People living with HIV (HIV+) are surviving longer due to effective antiretroviral therapy. Cardiovascular disease is a leading cause of non-AIDS related clinical events. We determined HIV-related factors associated with coronary artery stenosis progression. Read More

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A community-based study on electrocardiographic abnormalities of adult population from South India - Findings from a cross sectional survey.

Indian Heart J 2022 May 13. Epub 2022 May 13.

Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum Medical College, P.O., Thiruvananthapuram, Kerala, India. Electronic address:

Background: There are no data on electrocardiographic (ECG) findings from general population of Indian subcontinent. We analyzed ECG abnormalities of in adults as part of a community survey of prevalence of coronary artery disease and risk factors from South India.

Methods And Results: In this cross-sectional study of men and women between the ages 20 to 79 years, ECGs recorded digitally were analyzed using the Minnesota code. Read More

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Machine Learning for the Prevalence and Severity of Coronary Artery Calcification in Nondialysis Chronic Kidney Disease Patients: A Chinese Large Cohort Study.

J Thorac Imaging 2022 May 3. Epub 2022 May 3.

Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu.

Purpose: This study sought to determine whether machine learning (ML) can be used to better identify the risk factors and establish the prediction models for the prevalence and severity of coronary artery calcification (CAC) in nondialysis chronic kidney disease (CKD) patients and compare the performance of distinctive ML models with conventional logistic regression (LR) model.

Materials And Methods: In all, 3701 Chinese nondialysis CKD patients undergoing noncontrast cardiac computed tomography (CT) scanning were enrolled from November 2013 to December 2017. CAC score derived from the cardiac CT was calculated with the calcium scoring software and was used to assess and stratify the prevalence and severity of CAC. Read More

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A Systematic Review and Meta-Analysis of the Association Between Polycystic Ovary Syndrome and Coronary Artery Calcification.

J Womens Health (Larchmt) 2022 May 16. Epub 2022 May 16.

Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Polycystic ovary syndrome (PCOS) is a common endocrine pathology affecting women of reproductive age characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries. Coronary artery calcification (CAC) is a marker of subclinical atherosclerosis and prognostic of cardiovascular disease (CVD) risk. Some studies have shown that women with PCOS have a greater risk of CAC; however, a few others report contrary findings. Read More

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Prediction models as gatekeepers for diagnostic testing in angina patients with suspected chronic coronary syndrome.

Eur Heart J Qual Care Clin Outcomes 2022 May 16. Epub 2022 May 16.

Department of Cardiology, Bispebjerg Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

Aim: Assessment of pre-test probability (PTP) is an important gatekeeper when selecting patients for diagnostic testing for coronary artery disease (CAD). The 2019 European Society of Cardiology (ESC) guidelines recommend upgrading PTP based on clinical risk factors but provide no estimates of how these affect PTP. We aimed to validate two published PTP models in a contemporary low CAD prevalence cohort and compare with ESC 2019 PTP. Read More

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Factors predicting the occurrence of aortic valve calcification in patients with coronary artery calcification in China.

Acta Cardiol 2022 May 16:1-8. Epub 2022 May 16.

Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, P. R. China.

Objectives: In patients with coronary artery calcification (CAC), a predictor of adverse cardiovascular events, coronary computed tomography angiography (CCTA) also shows valvular calcification. In this study, we evaluated common clinical indicators in CAC patients with aortic (AoVC) and mitral valve (MVC) calcification.

Methods: CAC and valvular calcification were quantified using the Agatston score in 636 hospitalised patients with CAC who underwent CCTA. Read More

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A Biomarker-Enhanced Model for Prediction of Acute Kidney Injury and Cardiovascular Risk Following Angiographic Procedures: CASABLANCA AKI Prediction Substudy.

J Am Heart Assoc 2022 May 16;11(10):e025729. Epub 2022 May 16.

Massachusetts General Hospital Boston MA.

Background The 2020 Acute Disease Quality Initiative Consensus provided recommendations on novel acute kidney injury biomarkers. In this study, we sought to assess the added value of novel kidney biomarkers to a clinical score in the CASABLANCA (Catheter Sampled Blood Archive in Cardiovascular Diseases) study. Methods and Results We evaluated individuals undergoing coronary and/or peripheral angiography and added 4 candidate biomarkers for acute kidney injury (kidney injury molecule-1, interleukin-18, osteopontin, and cystatin C) to a previously described contrast-associated acute kidney injury (CA-AKI) risk score. Read More

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Stroke Risk Stratification in Patients With Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting.

J Am Heart Assoc 2022 May 16;11(10):e024703. Epub 2022 May 16.

Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Sweden.

Background The CHADS-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke or TIA [transient ischemic attack], vascular disease, age 65 to 74 years, sex category female; 2 indicates 2 points, otherwise 1 point) scoring system is recommended to guide decisions on oral anticoagulation therapy for stroke prevention in patients with nonsurgery atrial fibrillation. A score ≥1 in men and ≥2 in women, corresponding to an annual stroke risk exceeding 1%, warrants long-term oral anticoagulation provided the bleeding risk is acceptable. However, in patients with new-onset postoperative atrial fibrillation, the optimal risk stratification method is unknown. Read More

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