45,839 results match your criteria Risk Factors for Coronary Artery Disease


Postoperative complications associated with coronary artery bypass graft surgery and their therapeutic interventions.

Future Cardiol 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Coronary artery disease is one of the commonest surgery demanding cardiovascular diseases. Coronary artery bypass graft surgery is practiced all over the world for the treatment of coronary artery disease. Systemic trauma during the surgery is associated with a wide range of complications, some of which are fatal. Read More

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http://dx.doi.org/10.2217/fca-2019-0049DOI Listing

Identification of risk factors of acute coronary syndrome in young patients between 18-40 years of age at a teaching hospital.

Pak J Med Sci 2020 May-Jun;36(4):821-824

Zubair Akram. FACA, FCPS (Cardiology).Professor and Head, Department of Cardiology, Jinnah Hospital, Allama Iqbal Medical College, Lahore, Pakistan.

Objectives: To identify the risk factors in acute coronary syndrome.

Methods: It was a case series study, conducted in coronary care unit of Jinnah Hospital, Lahore from January to December 2018. Convenient sampling was used for patients' selection. Read More

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http://dx.doi.org/10.12669/pjms.36.4.2302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260892PMC

Pericardial adipose tissue is an independent risk factor of coronary artery disease and is associated with risk factors of coronary artery disease.

J Int Med Res 2020 Jun;48(6):300060520926737

Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, HeBei, China.

Objective: Pericardial adipose tissue volume (PATV) is related to the mechanism of coronary artery disease (CAD), but its association with CAD risk factors is not clear. This study aimed to investigate the relationships between PATV and its associated factors.

Methods: A total of 682 inpatients were consecutively enrolled in this study. Read More

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http://dx.doi.org/10.1177/0300060520926737DOI Listing

Pericardial fat volume and coronary atherosclerotic markers among body mass index groups.

Clin Cardiol 2020 Jun 3. Epub 2020 Jun 3.

Radiology Department, Medicine College, University Of Kufa, Najaf, Iraq.

Background: Increased pericardial fat volume (PFV) is associated with coronary atherosclerosis burden independent of body mass index (BMI) in many clinical studies. However, the association of PFV with markers of coronary atherosclerosis has not yet been assessed by dividing the patients according to BMI categories.

Hypothesis: To assess the association of PFV measured by multi-detector CT (MDCT) angiography with coronary atherosclerotic markers (coronary artery calcium score [CAC], plaque type, and luminal stenosis) among BMI categories. Read More

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http://dx.doi.org/10.1002/clc.23396DOI Listing

Serum apolipoprotein A-I concentration differs in coronary and peripheral artery disease.

Scand J Clin Lab Invest 2020 Jun 3:1-5. Epub 2020 Jun 3.

Center for Vascular Surgery and Interventional Radiology, Tampere University Hospital, Tampere, Finland.

Coronary artery and peripheral artery diseases represent different clinical outcomes of atherosclerosis and despite sharing common risk factors the ultimate reasons determining disease presentation are still unclear. The present study sought to define and compare the serum lipid and apolipoprotein profiles of patients undergoing coronary artery bypass grafting and those treated invasively for symptomatic lower extremity peripheral artery disease. Altogether 218 coronary and 280 peripheral artery disease patients treated between 2013 and 2014 in the Tampere University Hospital, Tampere, Finland, with available lipid measurements within two years prior to the intervention were retrospectively analysed. Read More

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http://dx.doi.org/10.1080/00365513.2020.1746974DOI Listing

Role of Interleukin-18 and the Thrombus Precursor Protein in Coronary Artery Disease.

Arq Bras Cardiol 2020 Apr 29;114(4):692-698. Epub 2020 May 29.

Fundação Pró Coração, Rio de Janeiro, RJ, Brasil.

Background Coronary failure is the leading cause of death worldwide and identifying patients at higher risk for coronary artery disease (CAD) is a challenge. Objectives To test the biomarkers interleukin 18 (IL-18) and thrombus precursor protein (TpP), involved in atherogenesis, to aid in the early assessment of CAD. Methods This was a cross-sectional cohort of 119 patients, stratified into three groups: Group I - acute coronary syndrome (39); Group II - chronic CAD (40) and Group III - control, without coronary lesion, but who might have risk factors for CAD (40). Read More

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http://dx.doi.org/10.36660/abc.20190176DOI Listing

Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups.

Int J Cardiol Heart Vasc 2020 Jun 29;28:100538. Epub 2020 May 29.

Departments of Medicine, University of Illinois at Chicago, USA.

Background: Although traditional risk factors for atrial fibrillation (AF) and its outcomes are established in whites, their role in the pathogenesis of AF across race-ethnicity and both sexes remain unclear. Cohort studies have consistently shown worse AF-related outcomes in these groups. The objective of this study was to determine the role played by race- and sex-specific risk factors in AF outcomes in non-Hispanic blacks (NHBs), Hispanics/Latinos (H/Ls), and non-Hispanic whites (NHWs). Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262442PMC

High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseases.

Iran J Basic Med Sci 2020 Apr;23(4):500-506

Department of Cardiology, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In this study the role of HTLV-1 infection was evaluated on cardiac involvement in an endemic region of northeastern Iran.

Materials And Methods: Serologic and molecular tests for HTLV-1 infection were carried out in subjects who had coronary angiography. Read More

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http://dx.doi.org/10.22038/ijbms.2020.36317.8649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239420PMC

MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability.

Open Heart 2020 Jun;7(1)

Department of Vascular Medicine, Amsterdam UMC, Location AMC, The University of Amsterdam, Amsterdam, The Netherlands

Background: In this study, we discovered and validated candidate microRNA (miRNA) biomarkers for coronary artery disease (CAD).

Method: Candidate tissue-derived miRNAs from atherosclerotic plaque material in patients with stable coronary artery disease (SCAD) (n=14) and unstable coronary artery disease (UCAD) (n=25) were discovered by qPCR-based arrays. We validated differentially expressed miRNAs, along with seven promising CAD-associated miRNAs from the literature, in the serum of two large cohorts (n=395 and n=1000) of patients with SCAD and UCAD and subclinical atherosclerosis (SubA) and controls, respectively. Read More

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http://dx.doi.org/10.1136/openhrt-2019-001223DOI Listing

Preoperative disturbances of glucose metabolism and mortality after coronary artery bypass grafting.

Open Heart 2020 Jun;7(1)

Medicine, Karolinska Institute, Stockholm, Stockholm County, Sweden

Background: Disturbances of glucose metabolism are important risk factors for coronary artery disease and are associated with an increased mortality risk. The aim was to investigate the association between preoperative disturbances of glucose metabolism and long-term all-cause mortality after coronary artery bypass grafting (CABG).

Methods: Patients undergoing a first isolated CABG in 2005-2013 were included. Read More

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http://dx.doi.org/10.1136/openhrt-2019-001217DOI Listing

The pregnancy-associated spontaneous coronary artery dissection in a young woman with a novel missense mutation in NOTCH1: a case report.

BMC Med Genet 2020 Jun 1;21(1):119. Epub 2020 Jun 1.

Department of Cardiology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University Health Science Center, No. 3002, Sungang West Road, Futian District, Shenzhen, 518035, China.

Background: Spontaneous coronary artery dissection (SCAD) is frequently reported as a disorder that primarily affects women without risk factors for cardiovascular disease. Although it has been recognized as one of the genetically mediated vascular disorders, the genetic pathogenesis of SCAD remains obscure to date.

Case Presentation: In this report, we presented a rare case of pregnancy-associated SCAD in a young woman that occurred in multiple coronary arteries within a short period. Read More

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http://dx.doi.org/10.1186/s12881-020-01058-2DOI Listing

Pregnancy and cardiac interventions: What are the optimal management options?

J Card Surg 2020 Jun 2. Epub 2020 Jun 2.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK.

Cardiac disease is the leading cause of maternal mortality in the United Kingdom. Major causes of cardiac death in pregnant women include cardiomyopathies, myocardial infarction, ischemic heart disease, and aortic dissection. Uncorrected congenital heart disease and women who have had corrective or palliative surgery may have complicated pregnancies as well. Read More

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http://dx.doi.org/10.1111/jocs.14637DOI Listing

Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors.

Eur J Prev Cardiol 2020 Jun 2:2047487320926780. Epub 2020 Jun 2.

Department of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Italy.

Aims: Ischaemic heart disease is classically associated with coronary artery disease. Recent evidences showed the correlation between coronary microvascular dysfunction and ischaemic heart disease, even independently of coronary artery disease. Ion channels represent the final effectors of blood flow regulation mechanisms and their genetic variants, in particular of Kir6. Read More

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http://dx.doi.org/10.1177/2047487320926780DOI Listing

Prevalence of Coronary Artery Calcification on Pre-Atrial Fibrillation Ablation CT Pulmonary Venograms and its Impact on Selection for Statin Therapy.

J Clin Med 2020 May 28;9(6). Epub 2020 May 28.

Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Atherosclerotic cardiovascular disease (ASCVD) shares many risk factors with atrial fibrillation (AF). Obtaining computed tomography images of the pulmonary veins (CTPV) before AF ablation procedures is common and can incidentally detect coronary artery calcification (CAC). The purpose of this study was to investigate the prevalence of CAC on pre-ablation CTPV, the frequency of CAC reporting on CTPV reports, and its impact on statin therapy among patients hospitalized for AF procedures. Read More

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http://dx.doi.org/10.3390/jcm9061631DOI Listing

Expression and clinical significance of serum cystatin C in patients with hypertension and coronary heart disease.

Medicine (Baltimore) 2020 May;99(22):e20029

NingBo First Hospital, Ningbo, Zhejiang, China.

The aim of this study is to explore the potential association between cystatin C (Cys-c) and coronary heart disease (CHD) in hypertensive patients.In this study, circulating levels of Cys-c in 62 essential hypertension (EH) patients, 147 hypertension with coronary heart disease (EH + CHD) patients, and 60 healthy volunteers were investigated using immunoturbidimetry. Then, we analyzed the correlations between Cys-C and other clinical parameters. Read More

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http://dx.doi.org/10.1097/MD.0000000000020029DOI Listing

High incidence of venous thromboembolism but not of coronary artery disease in granulomatosis with polyangiitis in first years after diagnosis.

Sarcoidosis Vasc Diffuse Lung Dis 2019 1;36(3):202-208. Epub 2019 May 1.

Medical University of Warsaw, Poland.

Objectives: Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is one of antineutrophil cytoplasmic autoantibody (ANCA) - associated vasculitis. In patients with GPA an increased incidence of venous thromboembolism (VTE), mainly during active disease, has been described. The aim of the present study was to assess the incidence of VTE and its relation with classic risk factors for atherosclerosis, presence of coronary artery disease (CAD), echocardiographic parameters and laboratory findings in GPA patients. Read More

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http://dx.doi.org/10.36141/svdld.v36i3.8088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247083PMC

Identification of pleiotropic genes between risk factors of stroke by multivariate metaCCA analysis.

Mol Genet Genomics 2020 May 30. Epub 2020 May 30.

Department of Global Biostatistics and Data Science, Tulane Center for Bioinformatics and Genomics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA.

Genome-wide association studies (GWASs) have identified more than 20 genetic loci as risk predictors associated with stroke. However, these studies were generally performed for single-trait and failed to consider the pleiotropic effects of these risk genes among the multiple risk factors for stroke. In this study, we applied a novel metaCCA method followed by gene-based VEGAS2 analysis to identify the risk genes for stroke that may overlap between seven correlated risk factors (including atrial fibrillation, hypertension, coronary artery disease, heart failure, diabetes, body mass index, and total cholesterol level) by integrating seven corresponding GWAS data. Read More

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http://dx.doi.org/10.1007/s00438-020-01692-8DOI Listing

Coronary artery bypass grafting in patients with concomitant solid tumours: early and long-term results.

Eur J Cardiothorac Surg 2020 May 31. Epub 2020 May 31.

Cardiac Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Objectives: Our goal was to analyse a consecutive series of patients with solid organ tumours undergoing coronary artery bypass grafting (CABG) by defining the risk factors for early and long-term outcomes.

Methods: Between 2005 and 2016, a consecutive series of 4079 patients underwent isolated CABG at our institution. Of 103 patients (2. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa114DOI Listing

The carotid plaque as paradigmatic case of site-specific acceleration of aging process: The microRNAs and the inflammaging contribution.

Ageing Res Rev 2020 May 28:101090. Epub 2020 May 28.

DIMES-Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; Interdepartmental Center - Alma Mater Research Institute on Global Challenges and Climate Change - University of Bologna, Bologna, Italy.

Atherosclerosis is considered a chronic inflammatory disease of arteries associated with the aging process. Many risk factors have been identified and they are mainly related to life-styles, gene-environment interactions and socioeconomic status. Carotid and coronary artery diseases are the two major atherosclerotic conditions, being the primary cause of stroke and heart attack, respectively. Read More

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http://dx.doi.org/10.1016/j.arr.2020.101090DOI Listing

Optimal Stenting Technique for Complex Coronary Lesions: Intracoronary Imaging-Guided Pre-Dilation, Stent Sizing, and Post-Dilation.

JACC Cardiovasc Interv 2020 May 23. Epub 2020 May 23.

Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Objectives: The study compared the 3-year outcomes of intracoronary imaging-guided pre-dilation, stent sizing, and post-dilation (iPSP) for patients with complex coronary artery lesions.

Background: The long-term effects of the optimal drug-eluting stent implantation technique in complex coronary artery disease have not been evaluated.

Methods: From the IRIS-DES (Interventional Cardiology Research In-cooperation Society-Drug-Eluting Stents) registry, the study evaluated 9,525 patients who underwent percutaneous coronary intervention for left main, bifurcation, long or diffuse (>30 mm), or angiographically severely calcified lesions. Read More

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http://dx.doi.org/10.1016/j.jcin.2020.03.023DOI Listing

Apolipoprotein CIII predicts cardiovascular events in patients with coronary artery disease: a prospective observational study.

Lipids Health Dis 2020 May 30;19(1):116. Epub 2020 May 30.

Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Background: Apolipoprotein CIII (apoCIII) is associated with triglyceride-rich lipoprotein metabolism and has emerged as independent marker for risk of cardiovascular disease. The objective was to test whether apoCIII is regulated postprandially and whether apoCIII concentrations in native and chylomicron-free serum predict future cardiovascular events in patients with stable coronary artery disease (CAD).

Methods: ApoCIII concentrations were measured in native and chylomicron-free serum in the fasting state and after a standardized oral fat load test in 195 patients with stable CAD. Read More

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http://dx.doi.org/10.1186/s12944-020-01293-9DOI Listing

Coronary artery disease in dialysis patients: evidence synthesis, controversies and proposed management strategies.

J Nephrol 2020 May 29. Epub 2020 May 29.

Nephrology Clinic, Dialysis and Renal Transplant Center-'C.I. Parhon' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality among patients with end-stage renal disease (ESRD). Clustering of traditional atherosclerotic and non-traditional risk factors drive the excess rates of coronary and non-coronary CVD in this population. The incidence, severity and mortality of coronary artery disease (CAD) as well as the number of complications of its therapy is higher in dialysis patients than in non-chronic kidney disease patients. Read More

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http://dx.doi.org/10.1007/s40620-020-00758-5DOI Listing

Disparities of demographics, clinical characteristics, and hospital outcomes of AMI pilgrims vs non-pilgrims-tertiary center experience.

Egypt Heart J 2020 May 29;72(1):31. Epub 2020 May 29.

King Abdullah Medical City, Muzdallfa Road, Makkah, Saudi Arabia.

Background: Acute myocardial infarction (AMI) is usually caused by rupture of an atherosclerotic plaque leading to thrombotic occlusion of a coronary artery. Cardiovascular disease has recently emerged as the leading cause of death during hajj. Our aim is to demonstrate the AMI pilgrim's related disparities and comparing them to non-pilgrim patients. Read More

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http://dx.doi.org/10.1186/s43044-020-00068-yDOI Listing

Predicting Contrast-Induced Renal Complications.

Interv Cardiol Clin 2020 Jul 11;9(3):321-333. Epub 2020 May 11.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, SPC 5869, Ann Arbor, MI 48109, USA. Electronic address:

Chronic kidney disease is a major risk factor for developing coronary artery disease, serving as an independent risk factor while overlapping with other risk factors. Percutaneous coronary intervention is a cornerstone of therapy for coronary artery disease and requires contrast media, which can contribute to renal injury. Identifying patients at risk for contrast-induced nephropathy is critical for preventing renal injury, which is associated with short- and long-term mortality. Read More

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http://dx.doi.org/10.1016/j.iccl.2020.02.003DOI Listing

Implications of Kidney Disease in the Cardiac Patient.

Interv Cardiol Clin 2020 Jul;9(3):265-278

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029-6574, USA. Electronic address:

Cardiovascular and renal diseases share common pathophysiological grounds, risk factors, and therapies. The 2 entities are closely interlinked and often coexist. The prevalence of kidney disease among cardiac patients is increasing. Read More

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http://dx.doi.org/10.1016/j.iccl.2020.03.002DOI Listing

Results of the CARDIA study suggest that higher dietary potassium may be kidney protective.

Kidney Int 2020 Apr 21. Epub 2020 Apr 21.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.

The association between dietary sodium and potassium intake with the development of kidney disease remains unclear, particularly among younger individuals. Here, we determined whether dietary sodium and potassium intake are associated with incident chronic kidney disease (CKD) using data from 1,030 adults (age 23-35 in 1990-1991) from the Coronary Artery Risk Development In Young Adults study, based on repeated measurements of estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (ACR) from 1995 through 2015. Urinary sodium and potassium excretion (mg/day), calculated from three 24-hour urine collections in 1990-1991, were averaged to measure sodium and potassium intake. Read More

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http://dx.doi.org/10.1016/j.kint.2020.02.037DOI Listing

Correlation between overweightness and the extent of coronary atherosclerosis among the South Caspian population.

BMC Cardiovasc Disord 2020 May 29;20(1):257. Epub 2020 May 29.

Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Reported effects of obesity on the extent of angiographic coronary artery disease(CAD) have been inconsistent. The present study aimed to investigate the relationships between the indices of obesity and other anthropometric markers with the extent of CAD.

Methods: This study was conducted on 1008 consecutive patients who underwent coronary angiography. Read More

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http://dx.doi.org/10.1186/s12872-020-01534-wDOI Listing

Minimal Patient Clinical Variables to Accurately Predict Stress Echocardiography Outcome: Validation Study Using Machine Learning Techniques.

JMIR Cardio 2020 May 29;4(1):e16975. Epub 2020 May 29.

Department of Cardiology, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, United Kingdom.

Background: Stress echocardiography is a well-established diagnostic tool for suspected coronary artery disease (CAD). Cardiovascular risk factors are used in the assessment of the probability of CAD. The link between the outcome of stress echocardiography and patients' variables including risk factors, current medication, and anthropometric variables has not been widely investigated. Read More

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http://dx.doi.org/10.2196/16975DOI Listing

Individualized coronary calcium scoring at any tube voltage using a kV-independent reconstruction algorithm.

Eur Radiol 2020 May 28. Epub 2020 May 28.

Department of Radiology and Radiological Sciences, Division of Cardiovascular Imaging, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC, USA.

Purpose: We prospectively investigate the feasibility of a patient specific automated tube voltage selection (ATVS)-based coronary artery calcium scoring (CACS) protocol, using a kV-independent reconstruction algorithm, to achieve significant dose reductions while maintaining the overall cardiac risk classification.

Methods: Forty-three patients (mean age, 61.8 ± 9. Read More

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http://dx.doi.org/10.1007/s00330-020-06951-1DOI Listing

Ascertainment Bias in the Association Between Elevated Lipoprotein(a) and Familial Hypercholesterolemia.

J Am Coll Cardiol 2020 Jun;75(21):2682-2693

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada; Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Background: Lipoprotein(a) is an atherogenic low-density lipoprotein-like particle and circulating levels are largely determined by genetics. Patients with familial hypercholesterolemia (FH) have elevated lipoprotein(a); however, it remains unclear why.

Objectives: This study compared the levels of lipoprotein(a) and associated genetic factors between individuals that were ascertained for FH clinically versus genetically. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.03.065DOI Listing

Post-Infectious Myocardial Infarction: Does Percutaneous Coronary Intervention Improve Outcomes? A Propensity Score-Matched Analysis.

J Clin Med 2020 May 26;9(6). Epub 2020 May 26.

Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2), EA 7460, University of Burgundy and Franche Comté, 21079 Dijon CEDEX, France.

Acute infection is a frequent trigger of myocardial infarction (MI). However, whether percutaneous coronary intervention (PCI) improves post-infectious MI prognosis is a major but unsolved issue. In this prospective multicenter study from coronary care units, we performed propensity score-matched analysis to compare outcomes in patients with and without PCI for post-infectious MI with angiography-proven significant coronary stenosis (>50%). Read More

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http://dx.doi.org/10.3390/jcm9061608DOI Listing

Increased prevalence of left ventricular diastolic dysfunction in adults with repaired coarctation of aorta.

Int J Cardiol Heart Vasc 2020 Jun 18;28:100530. Epub 2020 May 18.

The Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, United States.

Background: Left ventricular (LV) pressure overload and coronary artery disease are common in patients with coarctation of aorta (COA), and they are risk factors for LV diastolic dysfunction. Patients with COA may have aortic vasculopathy that can result in LV pressure overload even in the absence of hemodynamically significant COA. We therefore hypothesized that patients with mild COA (without hemodynamically significant COA) will have more LV diastolic dysfunction compared to controls. Read More

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http://dx.doi.org/10.1016/j.ijcha.2020.100530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240224PMC

Gender-specific associations of CD36 polymorphisms with the lipid profile and susceptibility to premature multi-vessel coronary artery heart disease in the Northern Han Chinese.

Gene 2020 May 24;753:144806. Epub 2020 May 24.

Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People's Republic of China. Electronic address:

Background: The aim of the present study was to detect potential gender-specific associations between some common CD36 single nucleotide polymorphisms (SNPs) and the lipid profile, as well as the susceptibility to premature multi-vessel coronary artery heart disease (CHD) in the Han population of Northern China.

Methods: A systematic three-step study process was employed to detect associations between CD36 gene variants and blood lipid profiles, as well as premature multi-vessel CHD in a gender-specific manner.

Results: The current study documented the following novel findings: (I) the full population-based association study in 329 Northern Han Chinese showed that four common CD36 polymorphisms were significantly related to extreme lipid profiles, with statistically significant effects based on gender interactions (rs1049673: P = 0. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144806DOI Listing

Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow.

BMC Cardiovasc Disord 2020 May 27;20(1):248. Epub 2020 May 27.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, PR China.

Objective: Coronary slow flow (CSF) is characterized by delayed opacification of distal epicardial coronary arteries without significant coronary stenosis. In addition, The changes of lipoprotein-associated phospholipase A2 (Lp-PLA) as a significant predictive factor for CSF remain controversial. The study aims to investigate the association between plasma Lp-PLA and CSF. Read More

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http://dx.doi.org/10.1186/s12872-020-01463-8DOI Listing

Evaluation of Psychological Stress Parameters in Coronary Patients by Three Different Questionnaires as Pre-Requisite for Comprehensive Rehabilitation.

Brain Sci 2020 May 22;10(5). Epub 2020 May 22.

Department of Cardiology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Background: Negative psychological conditions are common in patients with cardiovascular diseases. Although depression has been scrutinized over the years in these patients, only recently has anxiety emerged as another important risk factor. The purpose of this study was to compare the parameters of psychological stress in a population of coronary patients with and without myocardial revascularization procedures and to analyze lifestyle and socio-economic contributors to the state of health of these patients before inclusion in a comprehensive individualized rehabilitation program. Read More

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http://dx.doi.org/10.3390/brainsci10050316DOI Listing

Alzheimer's Disease and Cardiovascular Disease: A Particular Association.

Cardiol Res Pract 2020 5;2020:2617970. Epub 2020 May 5.

Department of Internal Medicine (DIMI) Clinic of Cardiovascular Diseases, University of Genoa, Genoa, Italy.

Methods: This review is based on the material obtained via MEDLINE (PubMed), EMBASE, and Clinical Trials databases, from January 1980 until May 2019. The search term used was "Alzheimer's disease," combined with "cardiovascular disease," "hypertension," "dyslipidaemia," "diabetes mellitus," "atrial fibrillation," "coronary artery disease," "heart valve disease," and "heart failure." Out of the 1,328 papers initially retrieved, 431 duplicates and 216 records in languages other than English were removed. Read More

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http://dx.doi.org/10.1155/2020/2617970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222603PMC

Association between serum phosphorus and subclinical coronary atherosclerosis in asymptomatic Korean individuals without kidney dysfunction.

Am J Clin Nutr 2020 May 26. Epub 2020 May 26.

Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: There are limited data regarding the relation between serum phosphorus concentration (SPC) and subclinical coronary atherosclerosis in the asymptomatic healthy population without kidney dysfunction.

Objectives: We aimed to investigate the relation between SPC and characteristics of atherosclerotic plaques and cardiac events according to SPCs using a large cohort of asymptomatic Korean individuals.

Methods: We evaluated 6329 asymptomatic Korean individuals [mean age: 53. Read More

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http://dx.doi.org/10.1093/ajcn/nqaa091DOI Listing

[Impact of type 2 diabetes mellitus on the progression and revascularization of coronary non-target lesions in patients with coronary heart disease].

Zhonghua Xin Xue Guan Bing Za Zhi 2020 May;48(5):393-400

Coronary Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing 100037, China.

To investigate the impact of type 2 diabetes mellitus on progression and revascularization of coronary non-target lesions in patients with coronary heart disease. From January 2010 to September 2014, we retrospectively analyzed the clinical data of patients with coronary heart disease who underwent two consecutive coronary angiographies at Fuwai Hospital. At least one coronary non-target lesion was recorded at the first procedure in these patients. Read More

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http://dx.doi.org/10.3760/cma.j.cn112148-20190425-00204DOI Listing

[Comparison of graft vessel versus native vessel strategies for late saphenous vein graft disease after coronary artery bypass grafting].

Zhonghua Xin Xue Guan Bing Za Zhi 2020 May;48(5):367-372

Tianjin Medical University, Tianjin 300070, China.

To compare clinical efficacy of interventional treatment with graft vessel and native coronary artery for patients with late saphenous vein grafts disease(SVGD) after coronary artery bypass grafting (CABG). A total of 1 608 patients underwent CABG in Tianjin Chest from March 2014 to December 2017 were screened. During the follow-up period, 165 hospitalized patients with recurrence of angina pectoris within one year after CABG, who had at least one narrow vein graft(≥50%) confirmed by the coronary angiography were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.cn112148-20190827-00523DOI Listing

Prevalence of asymptomatic coronary artery stenosis based on coronary computed tomography angiography in adults with erectile dysfunction: a cross-sectional study.

Med Princ Pract 2020 May 25. Epub 2020 May 25.

Objectives: To investigate the prevalence of asymptomatic coronary artery stenosis (CAS) using coronary computed tomography angiography (CCTA) in Korean men with erectile dysfunction (ED).

Subjects And Methods: A cross-sectional study was conducted. Subjects were 108 men who underwent CCTA at a health promotion center in Pusan National University Yangsan Hospital. Read More

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http://dx.doi.org/10.1159/000508876DOI Listing

Evidence linking the role of periodontal viruses in coronary artery disease with and without periodontitis.

J Periodontol 2020 May 25. Epub 2020 May 25.

Department of Periodontics, Priyadarshini Dental College and Hospital, Chennai, India.

Background: Viruses are considered to be a newer family associated with inflammatory diseases. Yet the role of periodontal viruses in coronary artery diseases (CAD) remains unclear. Thus the current study aims to evaluate the prevalence of periodontal viruses and compare the same in cardiac samples of CAD patients with and without periodontitis. Read More

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http://dx.doi.org/10.1002/JPER.19-0704DOI Listing

Comparison of myocardial blood flow and flow reserve with dobutamine and dipyridamole stress using rubidium-82 positron emission tomography.

J Nucl Cardiol 2020 May 24. Epub 2020 May 24.

University of Ottawa Heart Institute, University of Ottawa, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.

Background: The objective of this study was to compare the hyperemic myocardial blood flow (MBF) and myocardial flow reserve (MFR) obtained with dobutamine to those of dipyridamole in patients referred for myocardial perfusion imaging (MPI) using Rb positron emission tomography.

Methods: One hundred and fifty-six patients who underwent a Rb PET MPI study with dobutamine stress were included. A matching cohort of patients who underwent a Rb PET MPI study with dipyridamole stress was created, accounting for sex, age, history of coronary artery disease (CAD), prior revascularization, CAD risk factors, body mass index, and MPI interpretation. Read More

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http://dx.doi.org/10.1007/s12350-020-02186-1DOI Listing

Evaluation of plasminogen activator inhibitor-1 as a biomarker of unplanned revascularization and major adverse cardiac events in coronary angiography and percutaneous coronary intervention.

Thromb Res 2020 Jul 24;191:125-133. Epub 2020 Apr 24.

CAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Vascular Biology and Experimental Medicine Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address:

Background: The stented coronary artery remains at high-risk of complications, particularly in the form of stent thrombosis and in-stent restenosis. Improving our ability to identify patients at high-risk for these complications may provide opportunities for intervention. PAI-1 has been implicated in the pathophysiology of stent complications in preclinical studies, suggesting it may be a clinically valuable biomarker to predict adverse events following percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.04.025DOI Listing

Variations between women and men in risk factors, treatments, cardiovascular disease incidence, and death in 27 high-income, middle-income, and low-income countries (PURE): a prospective cohort study.

Lancet 2020 May 20. Epub 2020 May 20.

Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.

Background: Some studies, mainly from high-income countries (HICs), report that women receive less care (investigations and treatments) for cardiovascular disease than do men and might have a higher risk of death. However, very few studies systematically report risk factors, use of primary or secondary prevention medications, incidence of cardiovascular disease, or death in populations drawn from the community. Given that most cardiovascular disease occurs in low-income and middle-income countries (LMICs), there is a need for comprehensive information comparing treatments and outcomes between women and men in HICs, middle-income countries, and low-income countries from community-based population studies. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)30543-2DOI Listing

Permanent pacemaker implantation rates following cardiac surgery in the modern era.

Ir J Med Sci 2020 May 22. Epub 2020 May 22.

Royal Victoria Hospital, Belfast Health and Social Care Trust, 274 Grosvenor Road, Belfast, BT12 6BA, UK.

Aims: The aim of this study was to evaluate the incidence of permanent pacemaker (PPM) implantation after cardiac surgery in our institution and investigate risk factors for PPM dependency to provide patients with accurate incidence figures at the time of consent for surgery.

Methods: Data was collected retrospectively from a single tertiary institution from October 2018 to April 2019 inclusive of 403 patients. Incidence of PPM implantation after various cardiac operations was evaluated. Read More

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http://dx.doi.org/10.1007/s11845-020-02254-yDOI Listing

Coronary artery calcification scoring system based on the coronary artery calcium data and reporting system (CAC-DRS) predicts major adverse cardiovascular events or all-cause death in patients with potentially curable lung cancer without a history of cardiovascular disease.

Heart Vessels 2020 May 22. Epub 2020 May 22.

Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan.

The coronary artery calcium data and reporting system (CAC-DRS) is a novel reporting system based on CAC severity. Lung cancer patients have a high risk of cardiovascular disease (CVD), for which CAC severity may provide additional prognostic information. Using non-gated, non-contrast computed tomography (CT), we evaluated the CAC-DRS for predicting CVD and all-cause death in patients with potentially curable resected lung cancer. Read More

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http://dx.doi.org/10.1007/s00380-020-01624-xDOI Listing

Preoperative clopidogrel and outcomes in patients with acute coronary syndrome undergoing coronary artery bypass surgery.

J Thorac Cardiovasc Surg 2020 Apr 11. Epub 2020 Apr 11.

National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China; Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

Objective: The optimal preoperative antiplatelet strategy for patients with acute coronary syndrome (ACS) requiring surgical revascularization remains unclear because of competing risks of bleeding and ischemic events. We evaluated the effect of clopidogrel within 5 days before coronary artery bypass grafting (CABG) on outcomes in patients with ACS.

Methods: Consecutive patients with ACS who underwent isolated CABG at a single center were included in this retrospective study. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.03.118DOI Listing

Stroke in the patient with diabetes (part 1) - Epidemiology, etiology, therapy and prognosis.

Diabetes Res Clin Pract 2020 May 20:108193. Epub 2020 May 20.

Southside Endocrinology, Diabetes and Thyroid Associates, Birmingham, AL, United States. Electronic address:

There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the presence of atrial fibrillation. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108193DOI Listing

Evaluation of the associations of body height with blood pressure and early-stage atherosclerosis in Chinese adults.

J Clin Hypertens (Greenwich) 2020 May 22. Epub 2020 May 22.

Department of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, China.

Body height has been recently related to the risk of coronary heart disease and metabolic risk factors. However, data are scarce regarding the relationship between body height and early-stage atherosclerotic changes, especially in Chinese individuals. In this study, we aimed to comprehensively examine the associations of body height with early-stage atherosclerosis and blood pressure in Chinese adults. Read More

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http://dx.doi.org/10.1111/jch.13870DOI Listing