J Dermatol 2016 Aug 19;43(8):947-50. Epub 2016 Feb 19.

Department of Dermatology, Oita University, Kyoto, Japan.

Pigmented cosmetic dermatitis-like (Riehl's melanosis-like) pigmentation was reported in three of 27 patients with primary Sjögren's syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjögren's syndrome or anti-SSA antibody and possible associations with specific types of human leukocyte antigen (HLA) and infiltrating lymphocytes. Read More

J Cosmet Laser Ther 2015 Jun 20;17(3):135-8. Epub 2015 Feb 20.

Department of Dermatology, Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine , Seoul , Korea.

Riehl's melanosis, a form of dermatitis characterized by reticulate pigmentation, typically presents as a gray-brown to black hyperpigmentation on the face and neck. Among the various etiologic factors suggested, photoallergic reaction and pigmented contact dermatitis resulting from exposure to drugs, coal tar dyes, optical whitener, or other ingredients found in cosmetics are believed to be the major contributing factors in this disease. The histopathological features of Riehl's melanosis mainly consist of pigmentary incontinence along with infiltration of numerous dermal melanophages and lymphohistiocytes. Read More

J Cosmet Laser Ther 2014 Dec 13;16(6):290-2. Epub 2014 Aug 13.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Republic of Korea.

The treatment of Riehl's melanosis is difficult and challenging. Recently, a low-fluence 1064-nm quality (Q)-switched neodymium: yttrium-aluminum-garnet (Nd: YAG) laser method, referred to as 'laser toning', has been used in the treatment of melasma in Asian countries. We present here a series of cases of Riehl's melanosis that were treated effectively with a novel Q-switched Nd: YAG laser that was operated as a dual-pulse at half-fluence and 140-μs intervals. Read More

J Drugs Dermatol 2014 Mar;13(3):356-8

Riehl melanosis is a rare cause of skin hyperpigmentation that typically occurs on the face and neck and is characterized by the rapid onset of gray-brown reticular pigmentation. It is theorized to be a pigmented contact dermatitis or a lichenoid immune reaction that may be caused by intrinsic as well as extrinsic factors. Treatment is challenging; laser and intense pulsed light (IPL) therapy is a common treatment for other pigmented skin conditions. Read More

Br J Dermatol 2012 Mar;166(3):662-5

Department of Dermatology, Ajou University School of Medicine, San 5 Woncheon-dong, Yeongtong-gu, Suwon 443-721, Korea.

Background: Acquired bilateral patchy or mottled pigmentation of the neck has occasionally been observed.

Objective: To investigate the clinical and histopathological characteristics of this pigmentation.

Methods: Fourteen patients were included in the study. Read More

Przegl Lek 2009 ;66(3):145-9

Pracownia Inzynierii Komórkowej i Tkankowej Zakładu Biologii Komórki, Wydział Biochemii, Biofizyki i Biotechnologii, Uniwersytet Jagielloński, Kraków.

Skin disorders connected with pigmentation disturbances are most frequent dermatological problems. Different mechanisms are involved in these changes, mainly those which regulate melanocyte function. In this work we focused on molecular basis of pigmentation disorders in dermatological diseases that present clinically with hyperpigmentation (lentigo senilis, Riehl melanosis, seborrhoic keratosis, fibroma, café-au-lait patches melasma, atopic dermatitis) or hypopigmentation (vitiligo, albinism). Read More

Retin Cases Brief Rep 2007 ;1(3):145-6

From the Department of Ophthalmology, Peking University, People's Hospital, Beijing, China.

Purpose: To describe a case of idiopathic choroidal neovascularization (CNV) in a patient with Riehl melanosis.

Methods: Description of a 34-year-old woman with Riehl melanosis who developed CNV in the right eye.

Results: All other known causes of CNV were investigated and ruled out. Read More

J Dermatol 1994 May;21(5):363-6

Department of Dermatology, Hirosaki University School of Medicine, Japan.

An AIDS patient with the cardinal complaint of severe pigmentation on the face is reported. Hyperpigmentation is an unusual symptom of AIDS. This is a Japanese patient who presented melanosis Riehl-like discoloration. Read More

Int J Dermatol 1982 Mar;21(2):75-8

In Riehl's melanosis, first observed in 1917, facial hyperpigmentation, most pronounced on the forehead and in the zygomatic and/or temporal regions is the dominant symptom. Riehl could find no explanation for the condition, but suggested that certain foods used during the war could be responsible. Riehl's melanosis has later been observed in dark-complexioned people in whom hyperpigmentation with pigment incontinence may be the main sign of contact dermatitis caused by certain allergens. Read More

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