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Lasers Surg Med 2021 Jul 1;53(5):640-646. Epub 2020 Dec 1.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background And Objectives: The treatment of Riehl's melanosis, also known as pigmented contact dermatitis, is highly challenging. Intense pulsed light (IPL) and 1064 nm Q-switched Nd:Yag (QS-Nd:YAG) laser are reported to have some efficacy. However, no single effective treatment has yet been identified. Read More

Exp Dermatol 2021 Mar 10;30(3):396-401. Epub 2020 Dec 10.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The incidence of Riehl's melanosis (RM) is most common in the fifth or sixth decade of life with a female preponderance. As the skin is regarded a non-reproductive organ on which sex steroid hormones act, a possible relationship between the pathogenesis of RM and sex steroid hormone receptors can be inferred. This study intended to evaluate the expression profile of oestrogen receptor (ER)β and progesterone receptor (PR) in RM. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2020 Jun;29(2):81-83

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Riehl melanosis (RM) is a form of pigmented contact dermatitis that often poses a diagnostic challenge due to overlaps in its clinical, dermoscopic, and histopathological features with other pigmentary disorders. This report highlights significant findings and the proper approach for diagnosis. We present the case of a 47-year-old female with progressive facial hyperpigmentation (irregular, blotchy, grayish patches on the forehead, cheeks, and around the mouth) that acknowledged applying a lightening product before her complaint. Read More

Am J Dermatopathol 2020 Feb;42(2):117-121

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea; and.

Histological features of Riehl melanosis have rarely been compared between lesional and perilesional normal skin and have not been precisely described using quantitative or immunohistochemical analysis or electron microscopic findings. To investigate the histopathological and immunohistochemical features of lesional and perilesional normal skin of patients with Riehl melanosis, we retrospectively evaluated the electronic medical records and skin biopsy specimens of 48 patients with Riehl melanosis. In addition, electron microscopy was performed on 1 case. Read More

Lasers Surg Med 2020 10 17;52(8):753-760. Epub 2020 Jan 17.

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul, 06273, Korea.

Background And Objectives: Riehl's melanosis is a chronic acquired hyperpigmentation disorder that causes significant cosmetic problems for patients with this condition. Several treatment options, including low-fluence Q-switched Nd:YAG (QSNY) 1064-nm laser treatment, have been attempted with inconsistent results. We aimed to investigate the beneficial effect of mid-fluence QSNY 1064-nm laser in the treatment of Riehl's melanosis. Read More

J Cosmet Dermatol 2020 Jun 16;19(6):1377-1380. Epub 2019 Sep 16.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.

Background: Riehl's melanosis is a chronic, refractory disorder, which can adversely affect patient's quality of life. Intense pulse light, neodymium-doped yttrium aluminum garnet laser, hydroquinone, tranexamic acid have been reported to treat this disease, but there have been few reports on the effectiveness of other treatments.

Aim: To assess the efficacy and safety of triple combination therapy with salicylic acid chemical peels, oral glycyrrhizin compound, and vitamin C for Riehl's melanosis. Read More

Skin Res Technol 2019 Nov 24;25(6):871-876. Epub 2019 Jul 24.

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Objective: To describe the confocal laser scanning microscopy (CLSM) features of five different facial hyperpigmentation diseases and to highlight the features that can be used to differentiate between the diseases.

Materials And Methods: Confocal laser scanning microscopy features of skin lesions of 406 patients with different facial hyperpigmentation diseases (chloasma, naevus fusco-caeruleus zygomaticus, naevus of Ota, freckles and Riehl melanosis) were retrospectively analysed. All patients were diagnosed clinically. Read More

Ann Dermatol 2019 Apr 28;31(2):127-132. Epub 2019 Feb 28.

Department of Dermatology, Seoul National University Hospital, Seoul, Korea.

Background: Hyperpigmentation on the face and neck can be a devastating psychological burden in patients with Riehl's melanosis. However, successful treatment of the disease is challenging for clinicians.

Objective: To evaluate the effectiveness and safety of low-fluence neodymium-doped yttrium aluminum garnet (Nd:YAG) laser in the treatment of Riehl's melanosis and to identify prognostic factors determining the response to laser treatment. Read More

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Henna is a vegetable hair dye that can be used by individuals who are sensitized to oxidative dyes due to low allergenicity. The reported incidence of slate-grey facial dyspigmentation following the use of henna hair dye is extremely rare. This study aimed to identify the clinical, dermoscopic, and histopathological features of slate-grey facial dyspigmentation following the use of henna hair dye in Korean patients. Read More

J Dermatol 2016 Aug 19;43(8):947-50. Epub 2016 Feb 19.

Department of Dermatology, Oita University, Kyoto, Japan.

Pigmented cosmetic dermatitis-like (Riehl's melanosis-like) pigmentation was reported in three of 27 patients with primary Sjögren's syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjögren's syndrome or anti-SSA antibody and possible associations with specific types of human leukocyte antigen (HLA) and infiltrating lymphocytes. Read More

J Cosmet Laser Ther 2015 Jun 20;17(3):135-8. Epub 2015 Feb 20.

Department of Dermatology, Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine , Seoul , Korea.

Riehl's melanosis, a form of dermatitis characterized by reticulate pigmentation, typically presents as a gray-brown to black hyperpigmentation on the face and neck. Among the various etiologic factors suggested, photoallergic reaction and pigmented contact dermatitis resulting from exposure to drugs, coal tar dyes, optical whitener, or other ingredients found in cosmetics are believed to be the major contributing factors in this disease. The histopathological features of Riehl's melanosis mainly consist of pigmentary incontinence along with infiltration of numerous dermal melanophages and lymphohistiocytes. Read More

J Cosmet Laser Ther 2014 Dec 13;16(6):290-2. Epub 2014 Aug 13.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine , Seoul , Republic of Korea.

The treatment of Riehl's melanosis is difficult and challenging. Recently, a low-fluence 1064-nm quality (Q)-switched neodymium: yttrium-aluminum-garnet (Nd: YAG) laser method, referred to as 'laser toning', has been used in the treatment of melasma in Asian countries. We present here a series of cases of Riehl's melanosis that were treated effectively with a novel Q-switched Nd: YAG laser that was operated as a dual-pulse at half-fluence and 140-μs intervals. Read More

J Drugs Dermatol 2014 Mar;13(3):356-8

Riehl melanosis is a rare cause of skin hyperpigmentation that typically occurs on the face and neck and is characterized by the rapid onset of gray-brown reticular pigmentation. It is theorized to be a pigmented contact dermatitis or a lichenoid immune reaction that may be caused by intrinsic as well as extrinsic factors. Treatment is challenging; laser and intense pulsed light (IPL) therapy is a common treatment for other pigmented skin conditions. Read More

Br J Dermatol 2012 Mar;166(3):662-5

Department of Dermatology, Ajou University School of Medicine, San 5 Woncheon-dong, Yeongtong-gu, Suwon 443-721, Korea.

Background: Acquired bilateral patchy or mottled pigmentation of the neck has occasionally been observed.

Objective: To investigate the clinical and histopathological characteristics of this pigmentation.

Methods: Fourteen patients were included in the study. Read More

Przegl Lek 2009 ;66(3):145-9

Pracownia Inzynierii Komórkowej i Tkankowej Zakładu Biologii Komórki, Wydział Biochemii, Biofizyki i Biotechnologii, Uniwersytet Jagielloński, Kraków.

Skin disorders connected with pigmentation disturbances are most frequent dermatological problems. Different mechanisms are involved in these changes, mainly those which regulate melanocyte function. In this work we focused on molecular basis of pigmentation disorders in dermatological diseases that present clinically with hyperpigmentation (lentigo senilis, Riehl melanosis, seborrhoic keratosis, fibroma, café-au-lait patches melasma, atopic dermatitis) or hypopigmentation (vitiligo, albinism). Read More

Retin Cases Brief Rep 2007 ;1(3):145-6

From the Department of Ophthalmology, Peking University, People's Hospital, Beijing, China.

Purpose: To describe a case of idiopathic choroidal neovascularization (CNV) in a patient with Riehl melanosis.

Methods: Description of a 34-year-old woman with Riehl melanosis who developed CNV in the right eye.

Results: All other known causes of CNV were investigated and ruled out. Read More

J Dermatol 1994 May;21(5):363-6

Department of Dermatology, Hirosaki University School of Medicine, Japan.

An AIDS patient with the cardinal complaint of severe pigmentation on the face is reported. Hyperpigmentation is an unusual symptom of AIDS. This is a Japanese patient who presented melanosis Riehl-like discoloration. Read More

Int J Dermatol 1982 Mar;21(2):75-8

In Riehl's melanosis, first observed in 1917, facial hyperpigmentation, most pronounced on the forehead and in the zygomatic and/or temporal regions is the dominant symptom. Riehl could find no explanation for the condition, but suggested that certain foods used during the war could be responsible. Riehl's melanosis has later been observed in dark-complexioned people in whom hyperpigmentation with pigment incontinence may be the main sign of contact dermatitis caused by certain allergens. Read More

Bull Soc Fr Dermatol Syphiligr 1953 Mar-Apr;60(2):126-8

S Afr Med J 1952 May;26(18):373-5

Praxis 1949 Feb;38(6):136

Wien Klin Wochenschr 1949 Jan;61(3):41-3

Dermatologica 1949 ;98(4-6):336

Ned Tijdschr Geneeskd 1948 Oct;92(42):3361

Klin Med Osterr Z Wiss Prakt Med 1948 Oct;3(20):831

Wien Klin Wochenschr 1948 Oct;60(40):660

Klin Med Osterr Z Wiss Prakt Med 1948 Oct;3(19):787

Wien Klin Wochenschr 1948 Sep;60(35-36):594-6

Med Usine Rev Hyg Ind Mal Prof 1948 Jun;10(6):272-4