79 results match your criteria Riedel Thyroiditis

Immunoglobulin G4-Related Thyroid Disease: A Single-Center Experience and Literature Review.

Endocrinol Metab (Seoul) 2022 04 25;37(2):312-322. Epub 2022 Apr 25.

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Immunoglobulin G4 (IgG4)-related disease is an entity that can involve the thyroid gland. The spectrum of IgG4-related thyroid disease (IgG4-RTD) includes Hashimoto thyroiditis (HT) and its fibrotic variant, Riedel thyroiditis, as well as Graves' disease. The early diagnosis of IgG4-RTD is important because it is a medically treatable disease, and a delay in the diagnosis might result in unnecessary surgery. Read More

View Article and Full-Text PDF

Clinical Perspectives on IgG4-Related Disease and Its Classification.

Annu Rev Med 2022 01 20;73:545-562. Epub 2021 Oct 20.

Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; email:

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease. Since its discovery nearly two decades ago, our understanding of its pathophysiology and clinical manifestations has grown substantially. Early diagnosis and treatment of this elusive disease can prevent substantial organ damage from end-stage fibrosis, emphasizing the need for prompt recognition and accurate characterization of IgG4-RD. Read More

View Article and Full-Text PDF
January 2022

Long-Term Outcomes of Tamoxifen Citrate Therapy and Histo- and Immunopathological Properties in Riedel Thyroiditis.

Eur Thyroid J 2021 Jun 8;10(3):248-256. Epub 2020 Dec 8.

Department of Endocrinology and Metabolism, School of Medicine, Ankara University, Ankara, Turkey.

Background: Riedel thyroiditis (RT) is a rare form of thyroiditis; thus, data about the disease course and treatment options are limited. Therefore, we aimed to assess the clinical, serological, radiological, and histopathological features, as well as short- and long-term follow-up of RT patients under glucocorticoid (GC) and tamoxifen citrate (TMX). Parameters related to IgG4-related diseases (IgG4-RD) were also investigated. Read More

View Article and Full-Text PDF

IgG4-Related Retroperitoneal Fibrosis: A Rare Association With Riedel's Thyroiditis.

Cureus 2021 Mar 19;13(3):e13997. Epub 2021 Mar 19.

Endocrinology, Diabetes and Metabolism, Sanford Health, Fargo, USA.

Idiopathic retroperitoneal fibrosis is a rare fibro-inflammatory disease that can be associated with other IgG4-related diseases (IgG4-RDs). It is exceedingly uncommon to encounter this condition in a patient with Riedel's thyroiditis (RT), another disease in the IgG4-RD family. We present the case of a 53-year-old man with a history of RT who presented for severe localized lower abdominal and suprapubic pain due to obstructive uropathy from extensive retroperitoneal fibrosis. Read More

View Article and Full-Text PDF

IgG4 immunohistochemistry in Riedel's thyroiditis and the recommended criteria for diagnosis: A case series and literature review.

Clin Endocrinol (Oxf) 2021 05 21;94(5):851-857. Epub 2020 Dec 21.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Objective: Riedel's thyroiditis (RT) is a very rare chronic fibrosing thyroiditis that is often associated with multifocal fibrosclerosis. Although the relationship of RT and IgG4-related disease (IgG4-RD) has been suggested, the expression of IgG and IgG4 in thyroid tissues of patients with RT has seldom been studied.

Design: A case series and literature review. Read More

View Article and Full-Text PDF

The impact of the micronutrient iodine in health and diseases.

Crit Rev Food Sci Nutr 2022 23;62(6):1466-1479. Epub 2020 Nov 23.

Laboratorio de Endocrino-Inmunología, Facultad de Ciencias de la Vida, Departamento de Ciencias Biológicas, Universidad Andres Bello, Santiago, Chile.

Adequate iodine nutrition is crucial for all mammals by playing his starring role as a component of thyroid hormones, which are key regulators of cellular processes for life such as differentiation, growth, function, and metabolism. Deficiency or excess of iodine in the diet are worldwide highly frequent conditions that are responsible of health problems like hypothyroidism, hypothyroxinemia, goiter, thyroiditis, hyperthyroidism, and autoimmune thyroid diseases among others. The incorporation of iodine in salt or other nutrients resolved the consequences of severe iodine deficiency like goiter, cretinism. Read More

View Article and Full-Text PDF
February 2022

Riedel Thyroiditis.

J Clin Endocrinol Metab 2020 09;105(9)

Department of Endocrinology, Royal Darwin Hospital, Northern Territory, Australia.

Context: Riedel thyroiditis (RT) is a rare inflammatory autoimmune disease that is often a clinically diagnostic dilemma because of its insidious presentation and nonspecific symptoms.

Objective: The aim of the present systematic review and meta-analysis is to clarify the presentation, management, and outcomes of RT.

Study Selection: A systematic search of PubMed/MEDLINE and Web of Science was conducted to identify relevant reports published up to September 2019. Read More

View Article and Full-Text PDF
September 2020

Riedel's thyroiditis as a diagnostic dilemma - A case report and review of the literature.

Ann Med Surg (Lond) 2020 Apr 25;52:5-9. Epub 2020 Feb 25.

King Fahad Medical City, Makkah Road, Riyadh, 11525, Saudi Arabia.

Riedel's thyroiditis is a rare inflammatory process which not only involves thyroid gland but also the surrounding vital structures. It may also be associated with various forms of systemic fibrotic disorders. The exact etiology is not known, but currently, the most favored view is that of a localized form of the systemic fibrotic process. Read More

View Article and Full-Text PDF


AACE Clin Case Rep 2019 May-Jun;5(3):e218-e221. Epub 2019 Apr 25.

Objective: Riedel thyroiditis (RT) is a rare disorder with high morbidity and limited treatment options. We describe a case resistant to conventional treatment with corticosteroids and tamoxifen, which subsequently responded to rituximab.

Methods: Surgical pathology with hematoxylin and eosin staining was initially performed to confirm diagnosis, followed by IgG4 immunostaining and IgG4 serology in the setting of refractory RT, given its association with IgG4-related disease. Read More

View Article and Full-Text PDF


Georgian Med News 2019 May(290):116-120

2Akaki Tsereteli Kutaisi State University, Georgia.

Investigated 62 sample of thyroid gland obtained after surgical intervention, including: HT (n=27), RT (n=9), Graves' disease (n=17) and papillary thyroid carcinoma (n = 10). The slides were studied using classical histological and immunohistochemical methods: H&E, TTF1, TSH, S100-protein, CD56 and p63. Dispite of the histological and immunohistochemical heterogeneity of Thyroiditis HT and RT, the progressive involution of the glandular tissue with the replacement by the sever fibrosis, in some cases by the scar tissue is observed as damage sign. Read More

View Article and Full-Text PDF

Difficulties in diagnosis of Riedel's thyroiditis on aspiration cytology: A case report and brief review of the literature.

Diagn Cytopathol 2019 May 27;47(5):512-516. Epub 2018 Dec 27.

Surgery, Aga Khan University Hospital, Nairobi, Kenya.

Riedel's thyroiditis (RT) is a rare disorder characterized by extensive fibrosis extending to the extrathyroidal tissues. An elderly male presented with diffuse moderate thyromegaly and hoarseness of voice for two years. Radiology showed extrathyroidal extension around trachea with compression and deviation suggestive of malignancy. Read More

View Article and Full-Text PDF

Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity.

Arch Pathol Lab Med 2018 08;142(8):998-1005

From the Department of Pathology, Warren Alpert Medical School of Brown University, Lifespan Academic Medical Center, Providence, Rhode Island.

Plasma cell granuloma (PCG) is characterized by proliferation of polyclonal plasma cells with associated fibrosis and is often considered part of the heterogeneous group of inflammatory myofibroblastic tumors (IMTs). The thyroid is rarely affected by PCG. A patient having PCG associated with Hashimoto thyroiditis (HT) prompted our literature search that revealed 18 cases of PCG, 55% (n = 10) of which occurred together with HT. Read More

View Article and Full-Text PDF

Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?

Oncotarget 2018 Jan 20;9(2):2445-2467. Epub 2017 Dec 20.

Department of Surgical Oncology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Papillary thyroid cancer (PTC) is the most prevalent endocrine neoplasia. The increased incidence of PTC in patients with thyroiditis and the frequent immune infiltrate found in PTC suggest that inflammation might be a risk factor for PTC development. The CXCR3-ligand system is involved in thyroid inflammation and CXCR3 has been found upregulated in many tumors, suggesting its pro-tumorigenic role under the inflammatory microenvironment. Read More

View Article and Full-Text PDF
January 2018

Riedel's thyroiditis: clinical presentation, treatment and outcomes.

Endocrine 2018 04 29;60(1):185-192. Epub 2018 Jan 29.

Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.

Background: Riedel´s thyroiditis (RT) is a rare inflammatory disease of the thyroid gland, causing compression and fibrosis of adjacent tissues. Typically the goiter is hard and firm. Hoarseness, dyspnea, and dysphagia may be present. Read More

View Article and Full-Text PDF

Case report: IgG4-related mass-forming thyroiditis accompanied by regional lymphadenopathy.

Diagn Pathol 2018 Jan 3;13(1). Epub 2018 Jan 3.

Division of Diagnostic Pathology/Surgical Pathology, University of Fukui Hospital, Eiheiji, Japan.

Background: It has been recently accepted that IgG4-related thyroiditis is comparable to the Hashimoto and Riedel thyroiditis and Graves disease which are rich in IgG4-secreting plasma cells. Many physicians believe that in IgG4-related thyroiditis, the thyroid is entirely enlarged and diffusely affected, which is similar to conventional thyroiditis, but rarely ever accompanied by pseudoneoplastic mass formation as in IgG4-related disease in the other organs. This report introduces another pattern of IgG4-related thyroiditis as mass-forming thyroiditis and presents the occurrence of IgG4-related regional lymphadenopathy as an unusual accompanying symptom. Read More

View Article and Full-Text PDF
January 2018

Immunoglobulin G4-Related Thyroid Diseases.

Eur Thyroid J 2016 Dec 3;5(4):231-239. Epub 2016 Dec 3.

Department of Endocrinology and Diabetes, The Alfred Hospital, Monash University, Melbourne, VIC, Australia; Department of Medicine, Monash University, Melbourne, VIC, Australia.

Immunoglobulin G4-related disease (IgG4-RD) is a new disease category involving many organ systems, including the endocrine system in general and the thyroid in particular. Since an initial association was made between hypothyroidism and autoimmune (IgG4-related) pancreatitis, more forms of IgG4-related thyroid disease (IgG4-RTD) have been recognized. Four subcategories of IgG4-RTD have so far been identified: Riedel thyroiditis (RT), fibrosing variant of Hashimoto thyroiditis (FVHT), IgG4-related Hashimoto thyroiditis, and Graves disease with elevated IgG4 levels. Read More

View Article and Full-Text PDF
December 2016


Georgian Med News 2016 Nov(Issue):42-46

I. Javakhishvili Tbilisi State University, Alexandre Natishvili Institute of Morphology, Tbilisi, Georgia.

The present study was designed to evaluate the participation and utility of Hǘrtle cells morphological requirment and transformation under Hashimoto autoimmune thyroiditis versus Riedel´s struma. Several markers have been evaluated to detect induced activities of Hǘrtle cells. Study subject - specimens (tissue fragments) collected from TG surgery (thyroidectomy) for mollecular (receptor) diagnosis of Hǘrtle cells activities using routine histological and immunohistochemical samples. Read More

View Article and Full-Text PDF
November 2016

Severe trachea compression caused by Riedel's thyroiditis: A case report and review of the literature.

Ann Med Surg (Lond) 2016 Dec 24;12:18-20. Epub 2016 Oct 24.

Pathology Department, Cangzhou Clinical College of Integrated Traditional Chinese and Western Medicine of Hebei Medical University, Cangzhou 061000, China.

Background: Riedel's thyroiditis (RT) is a rare form of chronic thyroiditis, associated with fibroinflammatory process involving the thyroid and surrounding cervical tissues, leading to compressive symptoms.

Case Presentation: We present a case of RT in a 73-year-old female with dyspnoea caused by severe trachea compression. She had reported dyspnoea during physical stress, and had noticed a large mass on the front of the neck. Read More

View Article and Full-Text PDF
December 2016

Riedel's thyroiditis.

Radiol Case Rep 2016 Sep 17;11(3):175-7. Epub 2016 Jun 17.

Department of Fundamental Neurosciences, Universitiy of Geneva Medical School, Rue Michel-Servet 1, CH-1211 Geneva 4, Switzerland.

This article describes an unusual case of Riedel's thyroiditis and discusses its imagery, pathology, and treatment. Read More

View Article and Full-Text PDF
September 2016


Acta Endocrinol (Buchar) 2016 Jul-Sep;12(3):339-343

University Hospital Clinical Center Banja Luka - Department of Medical Supplies and Pharmacy KC, Banja Luka, Bosnia and Herzegovina.

Background: Riedel thyroiditis is a rare, chronic inflammatory disease of the thyroid, characterized by a dense fibrosis that replaces normal thyroid parenchyma. In literature descriptions of individual cases of Riedel thyroiditis can be found.

Case Report: We present an euthyroid patient with multinodular goiter who was diagnosed with Riedel thyroiditis using pathology. Read More

View Article and Full-Text PDF

Riedel's thyroiditis in a black African: A case report and review of literature.

Niger J Clin Pract 2016 Jul-Aug;19(4):549-555

Department of Surgery, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

Riedel's thyroiditis is a rare cause of the enlargement of the thyroid gland. The etiology is not fully known. There has been no report of Riedel thyroiditis in our country. Read More

View Article and Full-Text PDF

Immunoglobulin G4-Related Disease: Recent Advances in Pathogenesis and Imaging Findings.

Radiol Clin North Am 2016 May;54(3):535-51

Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Immunoglobulin G4-related disease (IgG4-RD) is a novel, immune-mediated, multisystem disease characterized by the development of tumefactive lesions in multiple organs. IgG4-RD encompasses many fibroinflammatory diseases that had been thought to be confined to single organs. Delayed diagnosis or misdiagnosis as malignancies leading to aggressive treatment may be averted by identification of the multisystem nature of IgG4-RD. Read More

View Article and Full-Text PDF

IgG4-related disease: The utility of (18)F-FDG PET/CT in diagnosis and treatment.

Hell J Nucl Med 2015 Sep-Dec;18 Suppl 1:155-9

Department of Rheumatology, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende, Ruddershove 10, B-8000 Brugge, Belgium.

Objective: IgG4-related disease (IgG4-RD) is a systemic mass-forming fibro-inflammatory condition which can affect nearly every organ system. Its pathophysiology remains incompletely understood, but affected tissues are characterized by a lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells which cause chronic inflammation, storiform fibrosis and phlebitis. These findings on histopathological specimens are considered the gold standard for the diagnosis. Read More

View Article and Full-Text PDF
September 2015

A small subgroup of Hashimoto's thyroiditis is associated with IgG4-related disease.

Virchows Arch 2016 Mar 15;468(3):321-7. Epub 2015 Dec 15.

Institute of Pathology, Staedtisches Klinikum Munich, Sanatoriumsplatz 2, 81545, Munich, Germany.

IgG4-related disease is a newly identified syndrome characterized by high serum IgG4 levels and increased IgG4-positive plasma cells in involved organs. The incidence of IgG4-related thyroiditis in the Caucasian population of Europe is unknown. We investigated formalin-fixed thyroid gland samples of 216 patients (191 Hashimoto's thyroiditis, 5 Riedel's thyroiditis, and 20 goiters, as controls), morphologically, and immunohistochemically. Read More

View Article and Full-Text PDF

The importance of IgG4 in the predictive model of thyroiditis.

Endocrinol Diabetes Metab Case Rep 2015 17;2015:150038. Epub 2015 Jun 17.

Department of Pathology, Militar Medical Academy , Crnotravska 1711000, Belgrade , Serbia.

Unlabelled: Immunoglobulin (Ig)G4-related sclerosing disease (IgG4-RSD) is a new disease entity first proposed with regard to autoimmune pancreatitis. A 67-year-old male patient was examined because of weight loss and an abdominal pain. Based on the clinical characteristics, laboratory parameters and ultrasound features, we identified the diagnosis of the IgG4-related systemic disease (IgG4-RSD), that was confirmed by the histopathological analysis after the biopsy of the head of pancreas. Read More

View Article and Full-Text PDF

IgG4-related disease.

Int J Rheum Dis 2016 Aug 10;19(8):747-62. Epub 2015 Aug 10.

Department of Allergy and Rheumatology, The University of Tokyo Hospital, Tokyo, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a regional or systemic fibro-inflammatory disease of unknown etiology. It presents a distinctive histopathological appearance of dense lymphoplasmacytic infiltrates with abundant IgG4-positive plasma cells, storiform fibrosis and obliterative phlebitis with the appearance of inflammatory swelling or tumefactive lesions. This new disease entity includes a wide variety of diseases such as Mikulicz disease, autoimmune pancreatitis, Riedel thyroiditis, interstitial nephritis and retroperitoneal fibrosis. Read More

View Article and Full-Text PDF

[Riedel thyroiditis].

Pan Afr Med J 2015 25;20:290. Epub 2015 Mar 25.

Service ORL, Hôpital Charles Nicolle, Tunis, Tunisie.

View Article and Full-Text PDF

Riedel thyroiditis: Fine needle aspiration findings of a rare entity.

Diagn Cytopathol 2015 Sep 7;43(9):747-50. Epub 2015 Jul 7.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York.

Riedel thyroiditis is a rare fibrosing disorder characterized by extension of the fibroinflammatory process beyond the thyroid capsule. Due to the nature of this lesion, fine-needle aspiration often yields scant material and may be interpreted as non-diagnostic. In this report, we describe cytologic features that allow the cytopathologist to favor a diagnosis of Riedel thyroiditis, thereby guiding appropriate further work-up and management. Read More

View Article and Full-Text PDF
September 2015