2,631 results match your criteria Rickettsialpox

Occurrence of Anti-Rickettsia spp. Antibodies in Hospitalized Patients with Undifferentiated Febrile Illness in the Southern Region of Kazakhstan.

Am J Trop Med Hyg 2021 Apr 26. Epub 2021 Apr 26.

11Bundeswehr Institute of Microbiology, Department Virology & Rickettsiology, German Center for Infection Research, Munich Partner site, Munich, Germany.

Undifferentiated febrile illness still represents a demanding medical problem all over the world, but primarily in low- and middle-income countries. Scientific and clinical investigations related to undifferentiated febrile illness and rickettsial diseases in Kazakhstan are lacking. This study reflects the investigation of antibodies against spotted fever group (SFG) and typhus group (TG) rickettsiae in patients with undifferentiated febrile illness in the southern region of Kazakhstan (Almaty and Kyzylorda oblasts). Read More

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Severe Case of Rickettsiosis Identified by Metagenomic Sequencing, China.

Emerg Infect Dis 2021 May;27(5):1530-1532

A case of Rickettsia sibirica subspecies sibirica BJ-90 infection in China was identified by metagenomic analysis of an eschar biopsy specimen and confirmed by nested PCR. Seroprevalence of spotted fever group Rickettsia was ≈17.4% among the local population. Read More

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Serological evidence of Rickettsia in horses from a semi-arid Brazilian region.

Rev Bras Parasitol Vet 2021 2;30(1):e026220. Epub 2021 Apr 2.

Laboratório de Doenças Parasitárias, Universidade Federal do Vale do São Francisco - UNIVASF, Petrolina, PE, Brasil.

Brazilian spotted fever (BSF) is a common tick-borne disease caused by Rickettsia rickettsii. Horses are the primary hosts of the main vector, Amblyomma sculptum, and are considered efficient sentinels for circulation of Rickettsia. Therefore, the aim of this study was to detect antibodies reactive to R. Read More

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Diversity of free-living ticks and serological evidence of spotted fever group Rickettsia and ticks associated to dogs, Porto Velho, Western Amazon, Brazil.

Exp Appl Acarol 2021 Apr 29;83(4):555-573. Epub 2021 Mar 29.

Bolsista Fundapam/Laboratório de Biologia do Carrapato, Embrapa Gado de Corte, Campo Grande, MS, Brazil.

Rondônia is the only state in the North Region of Brazil to have registered confirmed cases of Brazilian Spotted Fever (BSF). The present study investigated the epidemiological cycle of Rickettsia spp. by surveying free-living ixodofauna and tick parasitism of dogs in the municipality of Porto Velho, Rondônia State. Read More

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Isolation of Rickettsia rickettsii in Rocky Mountain Spotted Fever Outbreak, Panama.

Emerg Infect Dis 2021 Apr;27(4):1245-1247

We report new cases of Rocky Mountain spotted fever in patients from Kinkantu, Ngäbe-Bugle indigenous comarca, Panama. We isolated Rickettsia rickettsii in cell culture after intraperitoneal inoculation of guinea pigs with tissues from a deceased patient. Our results indicate that Rocky Mountain spotted fever is emerging in this region. Read More

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Significant Growth by Species within Human Macrophage-Like Cells Is a Phenotype Correlated with the Ability to Cause Disease in Mammals.

Pathogens 2021 Feb 19;10(2). Epub 2021 Feb 19.

Vector Borne Disease Laboratories, Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Baton Rouge, LA 70803, USA.

are significant sources of tick-borne diseases in humans worldwide. In North America, two species in the spotted fever group of have been conclusively associated with disease of humans: , the causative agent of Rocky Mountain spotted fever, and , the cause of rickettsiosis. Previous work in our lab demonstrated non-endothelial parasitism by another pathogenic SFG species, , within THP-1-derived macrophages, and we have hypothesized that this growth characteristic may be an underappreciated aspect of rickettsial pathogenesis in mammalian hosts. Read More

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February 2021

Amplicon-Based Next Generation Sequencing for Rapid Identification of and Ectoparasite Species from Entomological Surveillance in Thailand.

Pathogens 2021 Feb 16;10(2). Epub 2021 Feb 16.

Department of Entomology, US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok 10400, Thailand.

Background: Next generation sequencing (NGS) technology has been used for a wide range of epidemiological and surveillance studies. Here, we used amplicon-based NGS to species identify and their arthropod hosts from entomological surveillance.

Methods: During 2015-2016, we screened 1825 samples of rodents and ectoparasites collected from rodents and domestic mammals (dog, cat, and cattle) across Thailand for . Read More

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February 2021

Control of ixodid ticks and prevention of tick-borne diseases in the United States: The prospect of a new Lyme disease vaccine and the continuing problem with tick exposure on residential properties.

Lars Eisen

Ticks Tick Borne Dis 2021 05 20;12(3):101649. Epub 2021 Jan 20.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO, 80521, United States. Electronic address:

In the United States, exposure to human-biting ixodid ticks can occur while spending time on residential properties or in neighborhood green spaces as well as during recreational or occupational activities on public lands. Human-biting tick species collectively transmit >15 species of pathogenic microorganisms and the national burden of tick-borne diseases is increasing. The prospect of a new Lyme disease vaccine for use in humans provides hope for substantial reduction in the >450,000 estimated annual cases of Lyme disease but this breakthrough would not reduce cases of other tick-borne diseases, such as anaplasmosis, babesiosis, ehrlichiosis, spotted fever group rickettsiosis, and Powassan encephalitis. Read More

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Surveillance of Ticks and Tick-Borne Pathogens in Suburban Natural Habitats of Central Maryland.

J Med Entomol 2021 Jan 28. Epub 2021 Jan 28.

Invasive Insect Biocontrol and Behavior Laboratory, USDA, ARS, BARC-West, Beltsville, MD.

Lyme and other tick-borne diseases are increasing in the eastern United States and there is a lack of research on integrated strategies to control tick vectors. Here we present results of a study on tick-borne pathogens detected from tick vectors and rodent reservoirs from an ongoing 5-yr tick suppression study in the Lyme disease-endemic state of Maryland, where human-biting tick species, including Ixodes scapularis Say (Acari: Ixodidae) (the primary vector of Lyme disease spirochetes), are abundant. During the 2017 tick season, we collected 207 questing ticks and 602 ticks recovered from 327 mice (Peromyscus spp. Read More

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January 2021

Beyond the IFA: Revisiting the ELISA as a More Sensitive, Objective, and Quantitative Evaluation of Spotted Fever Group Exposure.

Pathogens 2021 Jan 20;10(2). Epub 2021 Jan 20.

Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA.

Based on limited serological studies, at least 10% of the US population has been exposed to spotted fever group (SFGR) species. The immunofluorescence antibody assay (IFA) has been the gold standard for the serodiagnosis of rickettsial infections such as spotted fever rickettsiosis (SFR). However, the IFA is semi-quantitative and subjective, requiring a high level of expertise to interpret it correctly. Read More

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January 2021

Urban ecology of hosts and vectors of Rickettsia in a rickettsiosis-endemic city of the Yucatan peninsula, Mexico.

Acta Trop 2021 Apr 16;216:105832. Epub 2021 Jan 16.

Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Universidad Autónoma de Yucatán, Av. Itzaes No. 490 × 59, Col. Centro, 97000 Mérida, Yucatán, México.

Rickettsioses are vector-borne zoonotic diseases that occur in urban environments. Currently, they are associated with the presence of domestic and synanthropic animals, the ectoparasites that they harbor, and their local habitat. The implementation of prevention actions relies on the understanding of the local ecology of interactions between hosts, vector species, and the etiologic agents. Read More

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Spotted fever group rickettsiae transmitted by ticks and determinants of their spread in Europe.

Ann Agric Environ Med 2020 Dec 7;27(4):505-511. Epub 2020 May 7.

Department of Health Promotion and Treatment of Obesity, Medical University of Silesia, Katowice, Poland.

Rickettsiae from the spotted fever group, i.e. the etiological agents of tick-borne lymphadenopathy/-borne necrotic erythema and lymphadenopathy (TIBOLA /DEBONEL) syndrome, are associated with ticks, including and The expansion of these ticks into new areas increases the risk of infection of their hosts with tick-borne pathogens. Read More

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December 2020

Rickettsial infection in equids, opossums and ticks in the municipality of Monte Mor, state of São Paulo, Brazil.

Rev Bras Parasitol Vet 2020 23;29(4):e015420. Epub 2020 Nov 23.

Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo - USP, São Paulo, SP, Brasil.

The aim of this study was to investigate rickettsial infection in equids, opossums and ticks in the municipality of Monte Mor, a place where a Brazilian spotted fever case occurred in 2005. In addition, characteristics possibly associated with seropositivity in horses were analyzed. Serum samples from horses, mules and opossums (Didelphis albiventris) were subjected to indirect immunofluorescence assay (IFA) against Rickettsia rickettsii. Read More

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January 2021

Knowledge, Attitudes, and Practices Related to Rocky Mountain Spotted Fever in Hermosillo, México.

Am J Trop Med Hyg 2021 01;104(1):184-189

4Department of Medicine and Health Sciences, University of Sonora, Hermosillo, Mexico.

Rocky Mountain spotted fever (RMSF) is a serious disease in northwest Mexico, particularly in low-income communities. This study aimed to evaluate RMSF-related knowledge, attitudes, and practices in an endemic urban area with a high burden of the disease. A cross-sectional study design using a non-probabilistic household survey was conducted with 400 residents in Hermosillo, Mexico. Read More

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January 2021

Is Rocky Mountain spotted fever the only disease of the spotted fever group rickettsioses found in Mexico?

Bol Med Hosp Infant Mex 2020 ;77(6):341-342

Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City. Mexico.

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December 2020

A Space-Time Permutation Scan Statistic for Evaluating County-Level Tickborne Disease Clusters in Indiana, 2009-2016.

Health Secur 2021 Jan-Feb;19(1):108-115. Epub 2020 Nov 6.

Oghenekaro Omodior, PhD, is an Assistant Professor, School of Public Health, Indiana University, Bloomington, IN.

The purpose of this study was to identify age group, gender, rural-urban differences, and spatiotemporal clusters of tickborne disease diagnoses in Indiana. We analyzed retrospective surveillance data for Lyme disease, ehrlichiosis, Rocky Mountain spotted fever, typhus/rickettsial diseases, and tularemia diagnosed in Indiana from 2009 to 2016. We used chi-square cross tabulation to test gender, age group, and county classification (rural, rural-mixed, urban) differences in tickborne disease. Read More

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Development of a Multiplex Loop-Mediated Isothermal Amplification (LAMP) Method for Simultaneous Detection of Spotted Fever Group Rickettsiae and Malaria Parasites by Dipstick DNA Chromatography.

Diagnostics (Basel) 2020 Nov 2;10(11). Epub 2020 Nov 2.

Division of collaboration and education, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Hokkaido, Japan.

Spotted fever group (SFG) rickettsiae causes febrile illness in humans worldwide. Since SFG rickettsiosis's clinical presentation is nonspecific, it is frequently misdiagnosed as other febrile diseases, especially malaria, and complicates proper treatment. Aiming at rapid, simple, and simultaneous detection of SFG spp. Read More

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November 2020

Epidemiology and Clinical Features of Rocky Mountain Spotted Fever from Enhanced Surveillance, Sonora, Mexico: 2015-2018.

Am J Trop Med Hyg 2021 01;104(1):190-197

2Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Rocky Mountain spotted fever (RMSF), caused by , is a severe and potentially fatal tick-borne disease. In 2015, Mexico issued a declaration of epidemiologic emergency in response to ongoing outbreaks of RMSF in northern Mexico. Sonora state is one of the most heavily impacted states in Mexico, with historic case fatality rates (CFRs) of 18%. Read More

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January 2021

Identification and Characterization of "Candidatus Rickettsia Thierseensis", a Novel Spotted Fever Group Rickettsia Species Detected in Austria.

Microorganisms 2020 Oct 28;8(11). Epub 2020 Oct 28.

Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, A-1090 Vienna, Austria.

spp. are the second most common pathogens detected in ticks in Austria after sensu lato. Species belonging to the spotted fever group (SFG) are the causative agents for tick-borne rickettsiosis across the world. Read More

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October 2020

Rickettsial pathogens circulating in urban districts of Rio de Janeiro, without report of human Brazilian Spotted Fever.

Rev Bras Parasitol Vet 2020 21;29(4):e014220. Epub 2020 Oct 21.

Pós-graduação em Medicina Veterinária, Clínica e Reprodução Animal, Faculdade de Veterinária, Universidade Federal Fluminense - UFF, Niterói, RJ, Brasil.

Spotted fever group rickettsioses are emerging diseases. In some of these diseases, domestic dogs act as sentinels. Canine serological studies have demonstrated that rickettsial dispersion is concentrated in rural areas, seroprevalence being higher where human rickettsioses are endemic. Read More

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January 2021

Neuroinflammation associated with scrub typhus and spotted fever group rickettsioses.

PLoS Negl Trop Dis 2020 10 22;14(10):e0008675. Epub 2020 Oct 22.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.

Scrub typhus and spotted fever rickettsioses (SFR) are understudied, vector-borne diseases of global significance. Over 1 billion individuals are at risk for scrub typhus alone in an endemic region, spanning across eastern and southern Asia to Northern Australia. While highly treatable, diagnostic challenges make timely antibiotic intervention difficult for these diseases. Read More

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October 2020

Prompt defervescence after initiation of treatment for rickettsial infections - time to dispense with the dogma?

Int J Infect Dis 2021 Jan 16;102:132-135. Epub 2020 Oct 16.

Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia; The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia. Electronic address:

Introduction: Clinicians are commonly taught that if patients with suspected rickettsial disease have continuing fever after 48 hours of anti-rickettsial therapy, an alternative diagnosis is likely.

Methods: This retrospective study of patients hospitalised with scrub typhus and Queensland tick typhus (QTT) in tropical Australia, examined the time to defervescence after initiation of the patients' anti-rickettsial therapy. It also identified factors associated with delayed defervescence (time to defervescence >48 hours after antibiotic commencement). Read More

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January 2021

Development and validation of an interactive educational technology on spotted fever.

Rev Lat Am Enfermagem 2020 30;28:e3375. Epub 2020 Sep 30.

Objective: to develop and validate an interactive educational technology on spotted fever, to offer an innovative teaching method.

Method: a methodological study that covered the following stages: analysis and diagnosis; instructional planning, didactic design, review, and validation and production of technology.

Results: the analysis and diagnosis were obtained from experiences in education and health activities for spotted fever. Read More

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October 2020

Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae.

Int J Mol Sci 2020 Sep 29;21(19). Epub 2020 Sep 29.

Department of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX 77555-0609, USA.

Attributed to the tropism for host microvascular endothelium lining the blood vessels, vascular inflammation and dysfunction represent salient features of rickettsial pathogenesis, yet the details of fundamentally important pathogen interactions with host endothelial cells (ECs) as the primary targets of infection remain poorly appreciated. Mechanistic target of rapamycin (mTOR), a serine/threonine protein kinase of the phosphatidylinositol kinase-related kinase family, assembles into two functionally distinct complexes, namely mTORC1 (Raptor) and mTORC2 (Rictor), implicated in the determination of innate immune responses to intracellular pathogens via transcriptional regulation. In the present study, we investigated activation status of mTOR and its potential contributions to host EC responses during and infection. Read More

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September 2020

Acute infectious purpura fulminans: a case series from India.

Trop Doct 2020 Oct 17;50(4):330-334. Epub 2020 Jun 17.

Professor, Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Acute infectious purpura fulminans is a serious, potentially fatal condition. We present a case series of 11 patients from March 2005 to March 2017, whose clinical symptoms were fever (100%), confusion (63.6%) and headache (55%), and whose common laboratory abnormalities were thrombocytopenia (100%), elevated alkaline phosphatase (70%) and anaemia (63. Read More

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October 2020

Mediterranean spotted fever in child and adult patients: investigation from an endemic region in Bulgaria.

Cent Eur J Public Health 2020 Sep;28(3):187-192

Medical University, Plovdiv, Bulgaria.

Objectives: Mediterranean spotted fever (MSF) is a tick-borne endemic disease caused by Rickettsia conorii conorii and transmitted to humans by the brown dog tick Rhipicephalus sanguineus. It is characterized by fever, maculopapular rash and a tick bite skin lesion "tache noire". The disease affects all age groups and usually has mild to moderate course. Read More

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September 2020

Records of ticks (Acari: Ixodidae) on humans and distribution of spotted-fever cases and its tick vectors in Paraná State, southern Brazil.

Ticks Tick Borne Dis 2020 11 10;11(6):101510. Epub 2020 Jul 10.

Vector-Borne Diseases Laboratory, Departamento de Medicina Veterinária, Universidade Federal do Paraná - UFPR, Curitiba, Paraná, Brazil; Global One Health initiative, The Ohio State University, Columbus, OH, USA. Electronic address:

Brazilian spotted fever (BSF) is the deadliest rickettsiosis in the world. Although the epidemiology of the disease has been established in Brazil, there are still limited data available on distribution of tick vectors and tick species parasitizing humans in the country, particularly in Paraná State. The State of Paraná is located in the southern region of the country and is covered by two biomes: Atlantic rainforest and Cerrado. Read More

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November 2020

The Characteristics and Clinical Course of Patients with Scrub Typhus and Queensland Tick Typhus Infection Requiring Intensive Care Unit Admission: A 23-year Case Series from Queensland, Tropical Australia.

Am J Trop Med Hyg 2020 12 17;103(6):2472-2477. Epub 2020 Sep 17.

The Kirby Institute, University of New South Wales, Sydney, Australia.

Scrub typhus and Queensland tick typhus (QTT)-rickettsial infections endemic to tropical Australia-can cause life-threatening disease. This retrospective study examined the clinical course of all patients with laboratory-confirmed scrub typhus or QTT admitted to the intensive care unit (ICU) of a tertiary referral hospital in tropical Australia between 1997 and 2019. Of the 22 patients, 13 had scrub typhus and nine had QTT. Read More

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December 2020

Detection of Tick-Borne Pathogens in Ticks from Dogs and Cats in the Yamagata Prefecture of Japan in 2018.

Jpn J Infect Dis 2021 Mar 31;74(2):122-128. Epub 2020 Aug 31.

Department of Microbiology, Yamagata Prefectural Institute of Public Health, Japan.

Companion animals can become infected with tick-borne diseases (TBDs) becoming a reservoir for human transfer, thereby damaging human health. To evaluate whether companion animals are infested with ticks harboring human TBD pathogens, we detected TBD pathogens in ticks collected from dogs and cats brought to animal hospitals in the Yamagata prefecture of Japan. An investigation of 164 adult ticks collected from 88 dogs and 41 cats between March and July 2018 revealed that this region was dominated by three tick species, Ixodes ovatus (n = 95, 57. Read More

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