Redox Status, Procoagulant Activity, and Metabolome of Fresh Frozen Plasma in Glucose 6-Phosphate Dehydrogenase Deficiency.
- Vassilis L Tzounakas,
- Federica Gevi,
- Hara T Georgatzakou,
- Lello Zolla,
- Issidora S Papassideri,
- Anastasios G Kriebardis,
- Sara Rinalducci,
- Marianna H Antonelou
Front Med (Lausanne) 2018 5;5:16. Epub 2018 Feb 5.
Department of Biology, School of Science, National and Kapodistrian University of Athens, Athens, Greece.
Objective: Transfusion of fresh frozen plasma (FFP) helps in maintaining the coagulation parameters in patients with acquired multiple coagulation factor deficiencies and severe bleeding. However, along with coagulation factors and procoagulant extracellular vesicles (EVs), numerous bioactive and probably donor-related factors (metabolites, oxidized components, etc.) are also carried to the recipient. Read More