1,247 results match your criteria Rhodococcus equi


-specific hyperimmune plasma administration decreases faecal shedding of pathogenic in foals.

Vet Rec 2019 Apr 17. Epub 2019 Apr 17.

Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.

is the most common cause of pneumonia in young foals. Pneumonic foals are an important source of environmental contamination as they shed higher amounts of in their faeces than unaffected foals. As -specific hyperimmune plasma (HIP) lessens clinical pneumonia, we hypothesise that its use would result in decreased faecal shedding of by foals. Read More

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http://veterinaryrecord.bmj.com/lookup/doi/10.1136/vr.105327
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http://dx.doi.org/10.1136/vr.105327DOI Listing
April 2019
1 Read

Foal-Level Risk Factors Associated With Development of Rhodococcus equi Pneumonia at a Quarter Horse Breeding Farm.

J Equine Vet Sci 2019 Jan 3;72:89-96. Epub 2018 Nov 3.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX.

The occurrence of Rhodococcus equi at farms varies, with disease occurring endemically at some farms, but only sporadically, or not at all at other farms. Only some foals residing on endemic farms develop clinical signs of disease. Limited evidence is available regarding foal-level risk factors for the development of R. Read More

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http://dx.doi.org/10.1016/j.jevs.2018.10.023DOI Listing
January 2019
1 Read

In vitro antimicrobial susceptibility of equine clinical isolates from France, 2006-2016.

J Glob Antimicrob Resist 2019 Mar 14. Epub 2019 Mar 14.

LABÉO Frank Duncombe, 14053 Caen, France; Normandie Univ, UNICAEN, U2RM, 14033 Caen, France. Electronic address:

Objectives: The aim of this study was to analyze the evolution of the antimicrobial susceptibility of equine pathogens isolated from clinical samples from 2006 to 2016.

Methods: A collection of 25,813 bacterial isolates were studied, clustered according to their origins (respiratory tract, cutaneous, genital and other) and analyzed for their antimicrobial susceptibility using the disk diffusion method.

Results: The most frequently isolated pathogens were group C Streptococci (27. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.03.006DOI Listing

Influence of bioaugmentation and biostimulation on PAH degradation in aged contaminated soils: Response and dynamics of the bacterial community.

J Environ Manage 2019 May 4;238:49-58. Epub 2019 Mar 4.

School of Science, RMIT University, Bundoora, Melbourne, VIC, 3083, Australia; Centre for Environmental Sustainability and Remediation, RMIT University, Bundoora, Melbourne, VIC, 3083, Australia. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) represent a group of hazardous compounds that are ubiquitous and persistent. The main aim of this study was to investigate the degradation of PAHs in chronically contaminated, aged and weathered soils obtained from a former gas plant of Australia. Biostimulation and bioaugmentation using individual isolates (Rhodococcus sp. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.115DOI Listing

Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii.

Microb Pathog 2019 Apr 6;129:112-117. Epub 2019 Feb 6.

UNESP-São Paulo State University, Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, Botucatu, State of São Paulo, Brazil. Electronic address:

Canine morbillivirus (previously, canine distemper virus, CDV) is a highly contagious infectious disease-causing agent that produces immunosuppressive infections and multiple clinical signs. Canine toxoplasmosis is an opportunistic disease characterized by enteric, pulmonary, and neuromuscular signs that might be confused with CDV-induced infections. Rhodococcus equi is a Gram-positive intracellular facultative bacterium that is also opportunistic in nature, and causes pyogranulomatous infections in humans and multiple host animals, although canine rhodococcosis is rare or unrecognized. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.01.048DOI Listing
April 2019
3 Reads

Ophthalmologic findings associated with Rhodococcus equi bronchopneumonia in foals.

Vet Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Departament de Medicina i Cirurgia Animal, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: To describe ocular findings associated with Rhodococcus equi bronchopneumonia in foals, and to determine whether severity of the ocular lesions is related with outcome.

Animals Studied: Foals diagnosed with R equi infection at the VTH-UAB from January 2002 to December 2017.

Procedure: Rhodococcus equi infection was diagnosed by means of clinical signs, radiographic/ultrasonographic findings, and/or positive culture. Read More

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http://dx.doi.org/10.1111/vop.12637DOI Listing
January 2019
1 Read

PNAG-specific equine IgG mediates significantly greater opsonization and killing of Prescottella equi (formerly Rhodococcus equi) than does IgG.

Vaccine 2019 Feb 26;37(9):1142-1150. Epub 2019 Jan 26.

College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, 660 Raymond Stotzer Pkwy, College Station, TX 77843-4475, United States. Electronic address:

Prescottella equi (formerly Rhodococcus equi) is a facultative intracellular bacterial pathogen that causes severe pneumonia in foals 1-6 months of age, whereas adult horses are highly resistant to infection. We have shown that vaccinating pregnant mares against the conserved surface polysaccharide capsule, β-1 → 6-linked poly-N-acetyl glucosamine (PNAG), elicits opsonic killing antibody that transfers via colostrum to foals and protects them against experimental infection with virulent. R. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.028DOI Listing
February 2019
2 Reads

Effect of Macrolide and Rifampin Resistance on the Fitness of Rhodococcus equi.

Appl Environ Microbiol 2019 Apr 22;85(7). Epub 2019 Mar 22.

Department of Large Animal Medicine, University of Georgia, Athens, Georgia, USA.

is a leading cause of severe pneumonia in foals. Standard treatment is dual antimicrobial therapy with a macrolide and rifampin, but the emergence of macrolide- and rifampin-resistant isolates is an increasing problem. The objective of this study was to determine the effect of macrolide and/or rifampin resistance on fitness of Three unique isogenic sets were created, each consisting of four strains, as follows: a susceptible parent isolate, strains resistant to macrolides or rifampin, and a dual macrolide- and rifampin-resistant strain. Read More

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http://dx.doi.org/10.1128/AEM.02665-18DOI Listing
April 2019
9 Reads

Rhodococcus equi Pneumonia in Kidney Transplant Recipient Affected by Acute Intermittent Porphyria: A Case Report.

Transplant Proc 2019 Jan - Feb;51(1):229-234. Epub 2018 Jun 30.

Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University of Modena and Reggio Emilia, Modena, Italy.

Rhodococcus equi is a gram-positive coccobacillus responsible for severe infections in patients with weakened immune systems. R equi generally causes pnumonia that may evolve into fatal systemic infection if left untreated. Here, we present a case of a 67-year-old woman affected by acute intermittent porphyria (AIP) who developed R equi pneumonia 7 months after kidney transplantation. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.213DOI Listing
March 2019
6 Reads

infection: A diverse spectrum of disease.

IDCases 2019 8;15:e00487. Epub 2019 Jan 8.

Infectious Diseases Service, Department of Medicine, Sunshine Coast University Hospital, QLD, Australia.

is a gram positive bacterium most commonly presenting clinically as pneumonia, however can disseminate to cause disease in virtually any human tissue. Although it is predominantly an opportunistic pathogen, a number of case series have described infection occurring among individuals with a normal immune system. We describe two cases of infection which highlight the diversity of disease presentations of this rare organism. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329319PMC
January 2019
1 Read

Enhancement of mixture pollutant biodegradation efficiency using a bacterial consortium under static magnetic field.

PLoS One 2019 4;14(1):e0208431. Epub 2019 Jan 4.

University of Carthage, Biochemistry and Molecular Biology Lab of Faculty of Sciences, Risks Related to Environmental Stress, Struggle and Prevention (UR17ES20), Bizerte, Zarzouna, Tunisia.

One of the main challenges of bioremediation is to define efficient protocols with low environmental impact and high removal rates, such as static magnetic field (SMF). The aim of this study was to evaluate the effect of SMF exposure on the biodegradation rate of a mixture of pollutants using three bacterial strains which were isolated and identified from the Bizerte lagoon: Pseudomonas stutzeri LBR (KC157911), Cupriavidus metallidurans LBJ (KU659610) and Rhodococcus equi LBB (KU743870). To recognize the improvement role of SMF, the culture was submitted to a pre-treatment with SMF with an induction equal to 200 mT for 5 hours, after that the degradation experiment was followed with individual strains and with a consortium. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208431PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319723PMC
January 2019
2 Reads

An inhibitory compound produced by a soil isolate of Rhodococcus has strong activity against the veterinary pathogen R. equi.

PLoS One 2018 28;13(12):e0209275. Epub 2018 Dec 28.

Department of Health Sciences, East Tennessee State University, Johnson City, TN, United States of America.

Complete genome sequencing of dozens of strains of the soil bacterium Rhodococcus has revealed the presence of many cryptic biosynthetic gene clusters, presumably dedicated to the production of small molecules. This has sparked a renewed interest in this underexplored member of the Actinobacteria as a potential source of new bioactive compounds. Reported here is the discovery of a potent inhibitory molecule produced by a newly isolated strain of Rhodococcus, strain MTM3W5. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209275PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310278PMC
December 2018
1 Read

Genome Analysis of Rhodococcus Sp. DSSKP-R-001: A Highly Effective -Estradiol-Degrading Bacterium.

Int J Genomics 2018 28;2018:3505428. Epub 2018 Oct 28.

School of Environment, Northeast Normal University, No. 2555 Jingyue Avenue, Changchun City, Jilin Province, China.

We screened bacteria that use E2 as its sole source of carbon and energy for growth and identified them as Rhodococcus, and we named them DSSKP-R-001. For a better understanding of the metabolic potential of the strain, whole genome sequencing of Rhodococcus DSSKP-R-001 and annotation of the functional genes were performed. The genomic sketches included a predicted protein-coding gene of approximately 5. Read More

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http://dx.doi.org/10.1155/2018/3505428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230383PMC
October 2018
2 Reads

Genomic Analysis of sp. Br-6, a Bromate Reducing Bacterium Isolated From Soil in Chiba, Japan.

J Genomics 2018 15;6:122-126. Epub 2018 Nov 15.

Graduate School of Horticulture, Chiba University, Matsudo City, Chiba, Japan.

Bromate is a byproduct of the ozone disinfection of drinking water. It is a genotoxic carcinogen and causes renal cell tumors in rats. Physicochemical removal of bromate is very difficult, making microbial reduction of bromate to bromide a promising approach to eliminate bromate from water. Read More

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http://dx.doi.org/10.7150/jgen.27741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275400PMC
November 2018
1 Read

Second line molecular diagnosis for bovine tuberculosis to improve diagnostic schemes.

PLoS One 2018 26;13(11):e0207614. Epub 2018 Nov 26.

University Paris-Est, French Agency for Food, Environmental and Occupational Health and Safety (Anses), Laboratory for Animal Health, Maisons-Alfort, France.

Surveillance of bovine tuberculosis (bTB) is partly based on the sanitary inspection of carcasses at the abattoir to detect bTB-like lesions which, in compliance with EU recommendations, are analysed by bacteriology and histopathology to disclose Mycobacterium bovis (or M. caprae) infection. Moreover, since 2012, a PCR method with similar sensitivity and specificity values of histopathology and bacteriology respectively is additionally employed in France, partially compensating for the weaknesses of classical diagnostic methods. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207614PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261039PMC
April 2019
2 Reads

Chronic cavitary pneumonia by Rhodococcus equi in a highly prevalent tuberculosis country: a diagnosis challenge.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e74. Epub 2018 Nov 14.

Universidade Federal do Rio Grande do Norte, Departamento de Infectologia, Natal, Rio Grande do Norte, Brazil.

Rhodococcus equi is a facultative aerobic, intracellular, non-motile, non-spore-forming, Gram-positive, weakly acid-fast coccobacillus belonging to the group of nocardioform actinomycetes. R. equi infections are rare opportunistic illnesses in patients with Acquired Immunodeficiency Syndrome (AIDS), associated with a high mortality rate. Read More

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http://dx.doi.org/10.1590/S1678-9946201860074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235427PMC
November 2018
17 Reads

Emergence of Resistance to Macrolides and Rifampin in Clinical Isolates of Rhodococcus equi from Foals in Central Kentucky, 1995 to 2017.

Antimicrob Agents Chemother 2019 Jan 21;63(1). Epub 2018 Dec 21.

Veterinary Diagnostic Laboratory, University of Kentucky, Lexington, Kentucky, USA.

The objective of this study was to determine the prevalence of strains resistant to macrolides and rifampin over time in clinical samples from foals submitted to diagnostic laboratories in central Kentucky. We performed a retrospective observational study of all clinical samples from foals that were submitted to veterinary diagnostic laboratories in Kentucky between January 1995 and December 2017. Samples were included if the bacterium was cultured and tested for susceptibility to erythromycin or rifampin. Read More

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http://dx.doi.org/10.1128/AAC.01714-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325176PMC
January 2019
22 Reads
4.480 Impact Factor

Identification of a VapA virulence factor functional homolog in Rhodococcus equi isolates housing the pVAPB plasmid.

PLoS One 2018 4;13(10):e0204475. Epub 2018 Oct 4.

Department of Infectious Disease, University of Georgia, Athens, Georgia, United States of America.

Rhodococcus equi is a facultative intracellular bacterium of macrophages and is an important pathogen of animals and immunocompromised people wherein disease results in abcessation of the lungs and other sites. Prior work has shown that the presence of the major virulence determinant, VapA, encoded on the pVAPA-type plasmid, disrupts normal phagosome development and is essential for bacterial replication within macrophages. pVAPA- type plasmids are typical of R. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204475PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171844PMC

Molecular analysis of the chromosomal 16S rRNA gene and vapA plasmid gene of Polish field strains of R. equi.

PLoS One 2018 25;13(9):e0204024. Epub 2018 Sep 25.

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Lublin, Poland.

Rhodococcus equi (R. hoagii) is an opportunistic pathogen commonly found in foals up to 6 months old and animal environment. The R. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204024PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155501PMC
March 2019
2 Reads

Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor.

Cell Microbiol 2019 Jan 9;21(1):e12958. Epub 2018 Nov 9.

Division of Biophysics, Cell Biology Institute, University of Bonn, Bonn, Germany.

Professional phagocytic cells such as macrophages are a central part of innate immune defence. They ingest microorganisms into membrane-bound compartments (phagosomes), which acidify and eventually fuse with lysosomes, exposing their contents to a microbicidal environment. Gram-positive Rhodococcus equi can cause pneumonia in young foals and in immunocompromised humans. Read More

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http://dx.doi.org/10.1111/cmi.12958DOI Listing
January 2019
9 Reads

Steroid Degradation in Comamonas testosteroni TA441: Identification of Metabolites and the Genes Involved in the Reactions Necessary before D-Ring Cleavage.

Appl Environ Microbiol 2018 Nov 30;84(22). Epub 2018 Oct 30.

Environmental Molecular Biology Laboratory, RIKEN, Saitama, Japan.

Bacterial steroid degradation has been studied mainly with () and as representative steroid degradation bacteria for more than 50 years. The primary purpose was to obtain materials for steroid drugs, but recent studies showed that many genera of bacteria (, , , etc.) degrade steroids and that steroid-degrading bacteria are globally distributed and found particularly in wastewater treatment plants, the soil, plant rhizospheres, and the marine environment. Read More

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http://aem.asm.org/lookup/doi/10.1128/AEM.01324-18
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http://dx.doi.org/10.1128/AEM.01324-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210104PMC
November 2018
9 Reads

Fecal shedding of Rhodococcus equi in mares and foals after experimental infection of foals and effect of composting on concentrations of R. equi in contaminated bedding.

Vet Microbiol 2018 Sep 21;223:42-46. Epub 2018 Jul 21.

Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Rhodococcus equi, a soil saprophyte, is a common cause of pneumonia in foals and a frequent opportunistic pathogen in immunosuppressed people. Because it is widespread in the environment, R. equi can be detected in the feces of most horses. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.07.017DOI Listing
September 2018
12 Reads

Current taxonomy of Rhodococcus species and their role in infections.

Eur J Clin Microbiol Infect Dis 2018 Nov 29;37(11):2045-2062. Epub 2018 Aug 29.

Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Rhodococcus is a genus of obligate aerobic, Gram-positive, partially acid-fast, catalase-positive, non-motile, and none-endospore bacteria. The genus Rhodococcus was first introduced by Zopf. This bacterium can be isolated from various sources of the environment and can grow well in non-selective medium. Read More

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http://dx.doi.org/10.1007/s10096-018-3364-xDOI Listing
November 2018
20 Reads

In vitro performances of novel co-spray-dried azithromycin/rifampicin microparticles for Rhodococcus equi disease treatment.

Sci Rep 2018 Aug 14;8(1):12149. Epub 2018 Aug 14.

Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia, 06123, Italy.

This work was aimed at providing clues on the in vitro performances of novel azithromycin/rifampicin combinations, in the form of co-spray-dried microparticles (AZM/RIF MP), against Rhodococcus equi, an animal and emerging human pathogen found responsible for worrying zoonosis. Various AZM/RIF combinations were spray-dried and characterized for their morphology and size. Susceptibility studies included determination of MIC, MBC, Fractional Inhibitory/Bactericidal Concentration Indexes and intracellular activity in R. Read More

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http://dx.doi.org/10.1038/s41598-018-30715-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092326PMC
August 2018
3 Reads
5.080 Impact Factor

Pulmonary malakoplakia secondary to Rhodococcus equi infection mimicking a lung neoplasm in a lung transplant recipient.

Am J Transplant 2019 Feb 4;19(2):597-600. Epub 2018 Sep 4.

Department of Surgery, The University of Virginia, Charlottesville, VA, USA.

Pulmonary masses occasionally occur after lung transplantation and vary in etiology, which includes malignant and benign conditions, such as infection. Here, we report a case of a patient presenting with a lung mass 3 years after lung transplant. To our knowledge, this is the first described case of pulmonary malakoplakia due to Rhodococcus equi infection in an allograft post-lung transplantation. Read More

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http://dx.doi.org/10.1111/ajt.15045DOI Listing
February 2019
5 Reads

Chronic Cavitary Infections Other than Tuberculosis: Clinical Aspects.

J Thorac Imaging 2018 Sep;33(5):322-333

Pulmonary Section, Denver Veterans Affairs Medical Center.

Lung cavitation may be due to infectious or noninfectious pathologic processes. The latter category includes nonmalignant conditions, such as granulomatosis with polyangiitis, and malignant conditions, such as squamous cell carcinoma of the lung. Infectious etiologies that produce lung cavitation usually cause chronic illness, although some, particularly pyogenic bacteria, may produce acute cavitary disease. Read More

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http://Insights.ovid.com/crossref?an=00005382-900000000-9958
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http://dx.doi.org/10.1097/RTI.0000000000000345DOI Listing
September 2018
7 Reads

Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi.

PLoS Pathog 2018 07 19;14(7):e1007160. Epub 2018 Jul 19.

Harvard Medical School, Brigham & Women's Hospital, Boston, MA, United States of America.

Immune correlates of protection against intracellular bacterial pathogens are largely thought to be cell-mediated, although a reasonable amount of data supports a role for antibody-mediated protection. To define a role for antibody-mediated immunity against an intracellular pathogen, Rhodococcus equi, that causes granulomatous pneumonia in horse foals, we devised and tested an experimental system relying solely on antibody-mediated protection against this host-specific etiologic agent. Immunity was induced by vaccinating pregnant mares 6 and 3 weeks prior to predicted parturition with a conjugate vaccine targeting the highly conserved microbial surface polysaccharide, poly-N-acetyl glucosamine (PNAG). Read More

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http://dx.doi.org/10.1371/journal.ppat.1007160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053243PMC
July 2018
3 Reads

Rhodococcus bacteria as a promising source of oils from olive mill wastes.

World J Microbiol Biotechnol 2018 Jul 10;34(8):114. Epub 2018 Jul 10.

Instituto de Biociencias de la Patagonia (INBIOP), Universidad Nacional de la Patagonia San Juan Bosco y CONICET, Km 4-Ciudad Universitaria 9000, Comodoro Rivadavia, Chubut, Argentina.

The accumulation of triacylglycerols (TAG) is a common feature among actinobacteria belonging to Rhodococcus genus. Some rhodococcal species are able to produce significant amounts of those lipids from different single substrates, such as glucose, gluconate or hexadecane. In this study we analyzed the ability of different species to produce lipids from olive oil mill wastes (OMW), and the possibility to enhance lipid production by genetic engineering. Read More

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http://dx.doi.org/10.1007/s11274-018-2499-3DOI Listing
July 2018
4 Reads

Purulent meningitis caused by Rhodococcus equi: A case report.

Medicine (Baltimore) 2018 Jun;97(24):e11156

Department of Neurology.

Rationale: Purulent meningitis refers infection of the subarachnoid space by various purulent bacteria and the corresponding inflammation of the leptomeninges. However, purulent meningitis due to Rhodococcus equi is extremely rare.

Patient Concerns: A 40-year-old man presented with fever and intermittent headache for 6 days. Read More

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http://dx.doi.org/10.1097/MD.0000000000011156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023960PMC
June 2018
3 Reads

Disseminated Rhodococcus equi in an Anglo-Nubian goat.

Vet Radiol Ultrasound 2018 Jun 5. Epub 2018 Jun 5.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907.

Disseminated Rhodococcus equi infection was diagnosed in an Anglo-Nubian goat presenting for non-weight bearing lameness of the right pelvic limb. Radiographs showed a moth-eaten osteolytic lesion in the proximal tibia suggestive of an aggressive bone lesion. Two pulmonary nodules were also present on thoracic radiographs. Read More

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http://dx.doi.org/10.1111/vru.12638DOI Listing
June 2018
4 Reads

Emergence of Leptin in Infection and Immunity: Scope and Challenges in Vaccines Formulation.

Front Cell Infect Microbiol 2018 9;8:147. Epub 2018 May 9.

School of Life Sciences, University of Hyderabad, Hyderabad, India.

Deficiency of leptin () and/or desensitization of leptin signaling () and elevated expression of suppressor of cytokine signaling-3 (SOCS3) reported in obesity are also reported in a variety of pathologies including hypertriglyceridemia, insulin resistance, and malnutrition as the risk factors in host defense system. Viral infections cause the elevated SOCS3 expression, which inhibits leptin signaling. It results in immunosuppression by T-regulatory cells (Tregs). Read More

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http://dx.doi.org/10.3389/fcimb.2018.00147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954041PMC
May 2018
2 Reads

Diagnosis and management of pulmonary infection due to Rhodococcus equi.

Clin Microbiol Infect 2019 Mar 16;25(3):310-315. Epub 2018 May 16.

Baylor College of Medicine, Houston, TX, USA; Infectious Disease Section, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA. Electronic address:

Background: Rhodococcus equi is a recognized cause of disease in humans, especially in individuals who are immunocompromised. Because diphtheroids are regarded as part of normal respiratory flora, the importance of R. equi as a pulmonary pathogen may not be fully appreciated and its prevalence may be underestimated. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.04.033DOI Listing
March 2019
5 Reads

Novel Kombucha Beverage from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum, with Antibacterial and Antioxidant Effects.

Int J Med Mushrooms 2018 ;20(3):243-258

lnstitute for Food Technology and Biochemistry, Faculty of Agriculture, University of Belgrade, Belgrade, Serbia.

Kombucha is a nonalcoholic beverage traditionally made by fermenting black tea using a combination of yeast and acetic acid bacteria (AAB) cultures. Ganoderma lucidum hot water extract (HWE) was used-to our knowledge for the first time-to prepare a novel, health-promoting kombucha product. During the 11-day fermentation, pH, total acidity, and the numbers of yeasts and AAB were monitored. Read More

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http://www.dl.begellhouse.com/journals/708ae68d64b17c52,0882
Publisher Site
http://dx.doi.org/10.1615/IntJMedMushrooms.2018025833DOI Listing
September 2018
17 Reads

B-Cell Epitope Mapping Using a Library of Overlapping Synthetic Peptides in an Enzyme-Linked Immunosorbent Assay.

Methods Mol Biol 2018 ;1785:121-128

SA Pathology, Adelaide, SA, Australia.

This chapter describes a strategy for mapping linear B-cell epitopes of proteins using synthetic biotinylated peptides in an ELISA.A set of overlapping peptides were designed based upon a known amino acid sequence of the target protein, VapA (Virulence-associated Protein A) of the bacterium Rhodococcus equi, an important pulmonary pathogen in foals. The peptides synthesized as biotinylated peptides were coated directly onto micro titer plates which had been pre-coated with NeutrAvidin™ and used to screen sera from foals confirmed to have R. Read More

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http://link.springer.com/10.1007/978-1-4939-7841-0_8
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http://dx.doi.org/10.1007/978-1-4939-7841-0_8DOI Listing
January 2019
3 Reads

Isolated Mediastinal Lymphadenopathy Caused by Rhodococcus equi Infection.

Ann Thorac Surg 2018 Aug 31;106(2):e77-e79. Epub 2018 Mar 31.

Department of Thoracic Surgery, Tartu University Hospital, Tartu, Estonia.

Mediastinal lymphadenopathy is common finding in thoracic surgery, and it often requires morphologic confirmation to establish the definitive diagnosis. The most frequent diagnoses are metastatic lung cancer, sarcoidosis, lymphoma, tuberculosis, and other causes of granulomatous infections. Rhodococcus equi is a rare pathogen in humans that mostly affects immunocompromised patients. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.02.072DOI Listing
August 2018
6 Reads

A case report on disseminated Rhodococcus equi infection in a Japanese black heifer.

J Vet Med Sci 2018 May 29;80(5):819-822. Epub 2018 Mar 29.

Laboratory of Animal Hygiene, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034-8628, Japan.

Rhodococcus equi was isolated from the granulomatous lesions of the lung, kidney, liver, and hepatic, mesenteric, and abomasum lymph nodes of a Japanese black heifer. R. equi isolates were analyzed by polymerase chain reaction for virulence-associated protein genes. Read More

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http://dx.doi.org/10.1292/jvms.18-0064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989029PMC
May 2018
1 Read

Identification of Mycobacterium species and Rhodococcus equi in peccary lymph nodes.

Trop Anim Health Prod 2018 Aug 15;50(6):1319-1326. Epub 2018 Mar 15.

Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, UNESP-São Paulo State University, Botucatu, SP, Brazil.

Mycobacterium species and the virulence-associated proteins (vapA, vapB, and vapN genes) of Rhodococcus equi isolated from 330 lymph nodes of collared peccaries (Tayassu tajacu) and white-lipped peccaries (Tayassu pecari) intended for human consumption were investigated. Thirty-six (10.9%) R. Read More

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http://dx.doi.org/10.1007/s11250-018-1562-2DOI Listing
August 2018
8 Reads

Guinea pig infection with the intracellular pathogen Rhodococcus equi.

Vet Microbiol 2018 Feb 21;215:18-22. Epub 2017 Nov 21.

Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA. Electronic address:

Rhodococcus equi is an opportunistic, intracellular pathogen that causes pyogranulomatous pneumonia in foals and immunocompromised people. Currently, there is no experimental model of R. equi pneumonia other than intra-bronchial experimental infection of foals with R. Read More

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http://dx.doi.org/10.1016/j.vetmic.2017.11.019DOI Listing
February 2018
10 Reads

Development of septic polysynovitis and uveitis in foals experimentally infected with Rhodococcus equi.

PLoS One 2018 7;13(2):e0192655. Epub 2018 Feb 7.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America.

Rhodococcus equi is one of the most important causes of disease in foals. Infection is typically characterized by pyogranulomatous pneumonia although extrapulmonary infections occur occasionally. Uveitis and polysynovitis have been reported in foals naturally infected with R. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192655PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802921PMC
April 2018
11 Reads

Prevalence of Rhodococcus equi from the nasal cavity of 1010 apparently healthy horses.

Equine Vet J 2018 Sep 5;50(5):667-671. Epub 2018 Feb 5.

Laboratory of Bacteriology, Federal University of Santa Maria (UFSM), Cidade Universitária, Bairro Camobi, Santa Maria - Rio Grande do Sul, Brazil.

Background: Rhodococcus equi is an important cause of foal pneumonia. While its isolation from different sources has been widely evaluated, there is a need to better understand the R. equi epidemiology from samples of the nasal cavity of healthy horses. Read More

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http://dx.doi.org/10.1111/evj.12804DOI Listing
September 2018
5 Reads

Detection of vapN in Rhodococcus equi isolates cultured from humans.

PLoS One 2018 4;13(1):e0190829. Epub 2018 Jan 4.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America.

Rhodococcus equi can cause severe infections in people, particularly in immunocompromised individuals. The R. equi virulence plasmids (vap) encoding vapA and vapB are linked to development of infections in domestic animals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190829PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754133PMC
February 2018
4 Reads

Rhodococcus equi Infections in Goats: Characterization of Virulence Plasmids.

Vet Pathol 2018 03 18;55(2):273-276. Epub 2017 Dec 18.

1 Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA.

Rhodococcus equi is an uncommon cause of systemic pyogranulomatous infections in goats with macroscopic similarities to caseous lymphadenitis caused by Corynebacterium pseudotuberculosis. Caprine cases have previously been reported to be caused by avirulent R. equi strains. Read More

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http://journals.sagepub.com/doi/10.1177/0300985817747327
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http://dx.doi.org/10.1177/0300985817747327DOI Listing
March 2018
7 Reads

Effects of priming with cytokines on intracellular survival and replication of Rhodococcus equi in equine macrophages.

Cytokine 2018 02 12;102:7-11. Epub 2017 Dec 12.

Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.

Rhodococcus equi is a common cause of pneumonia in foals and an opportunistic pathogen in immunosuppressed people. The ability of R. equi to survive and replicate in macrophages is the basis of its pathogenicity. Read More

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http://dx.doi.org/10.1016/j.cyto.2017.12.011DOI Listing
February 2018
11 Reads

Intestinal and hepatic contributions to the pharmacokinetic interaction between gamithromycin and rifampicin after single-dose and multiple-dose administration in healthy foals.

Equine Vet J 2018 Jul 8;50(4):525-531. Epub 2018 Jan 8.

Department of Clinical Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine of Greifswald, Greifswald, Germany.

Background: Standard treatment of foals with severe abscessing lung infection caused by Rhodococcus equi using rifampicin and a macrolide antibiotic can be compromised by extensive inhibition and/or induction of drug metabolising enzymes (e.g. CYP3A4) and transport proteins (e. Read More

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http://dx.doi.org/10.1111/evj.12796DOI Listing
July 2018
12 Reads

Induction of Reactive Intermediates and Autophagy-Related Proteins upon Infection of Macrophages with .

Scientifica (Cairo) 2017 1;2017:8135737. Epub 2017 Nov 1.

Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.

is an intracellular macrophage-tropic pathogen with potential for causing fatal pyogranulomatous pneumonia in foals between 1 and 6 months of age. In this study, we sought to determine whether infection of macrophages with could lead to the induction of autophagy. Murine bone marrow derived macrophages (BMDM) were infected with for various time intervals and analyzed for upregulation of autophagy proteins and accumulation of autophagosomes relative to uninfected controls. Read More

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http://dx.doi.org/10.1155/2017/8135737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688232PMC
November 2017
4 Reads

Novel bovine-associated pVAPN plasmid type in Rhodococcus equi identified from lymph nodes of slaughtered cattle and lungs of people living with HIV/AIDS.

Transbound Emerg Dis 2018 Apr 10;65(2):321-326. Epub 2017 Dec 10.

Kitasato University, Towada, Aomori, Japan.

Rhodococcus equi is a well-recognized Gram-positive intracellular facultative bacterium that is opportunistic in nature, which causes pyogranulomatous infections in humans and multiple host animals. The pathogenicity of the microorganism has been attributed to the presence of plasmid-encoded virulence-associated proteins (Vap). To date, three host-associated virulence plasmid types of R. Read More

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http://dx.doi.org/10.1111/tbed.12785DOI Listing
April 2018
3 Reads

VapA of Rhodococcus equi binds phosphatidic acid.

Mol Microbiol 2018 02 22;107(3):428-444. Epub 2017 Dec 22.

Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.

Rhodococcus equi is a multihost, facultative intracellular bacterial pathogen that primarily causes pneumonia in foals less than six months in age and immunocompromised people. Previous studies determined that the major virulence determinant of R. equi is the surface bound virulence associated protein A (VapA). Read More

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http://dx.doi.org/10.1111/mmi.13892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777868PMC
February 2018
15 Reads

Development of a multilocus sequence typing scheme for Rhodococcus equi.

Vet Microbiol 2017 Oct 19;210:64-70. Epub 2017 Aug 19.

ANSES, Dozulé Laboratory for Equine Diseases, Bacteriology and Parasitology Unit, 14430 Dozulé, France.

Rhodococcus equi causes pulmonary and extrapulmonary infections in animals and humans, with endemic situations and significant young foal mortality in stud farms worldwide. Despite its economic impact in the horse-breeding industry, the broad geographic and host distribution, global diversity and population structure of R. equi remain poorly characterised. Read More

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http://dx.doi.org/10.1016/j.vetmic.2017.08.010DOI Listing
October 2017
8 Reads

Antimicrobial Resistance in .

Microbiol Spectr 2017 10;5(5)

Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30605.

Pneumonia caused by remains an important cause of disease and death in foals. The combination of a macrolide (erythromycin, azithromycin, or clarithromycin) with rifampin has been the recommended treatment for foals with clinical signs of infection caused by since the early 1980s with, until recently, only rare reports of resistance. Resistance to macrolides and rifampin in isolates of cultured from horses is increasing, with isolates resistant to all macrolides and rifampin now being cultured from up to 40% of infected foals at some farms. Read More

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http://dx.doi.org/10.1128/microbiolspec.ARBA-0004-2016DOI Listing
October 2017
14 Reads