J Nat Prod 2022 Jun 31;85(6):1641-1657. Epub 2022 May 31.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Chemical investigation of Australian pasture plant-derived sp. CMB-PB041, supported by miniaturized cultivation profiling and molecular network analysis, led to the isolation and characterization of 13 new macrocyclic spirotetronates, glenthmycins A-M (-), with structures assigned by detailed spectroscopic analysis, chemical degradation and derivatization, and mechanistic and biosynthetic considerations. Hydrolysis of glenthmycin B () yielded the aglycone , whose structure and absolute configuration were secured by X-ray analysis, along with the unexpected amino sugar residues glenthose lactams A () and B (), with Mosher analysis of facilitating assignment of absolute configurations of the amino sugar. Read More