1,291 results match your criteria Rhodococcus equi


Infective Endocarditis Caused by Rhodococcus equi in an Immunocompetent Patient.

Cureus 2020 Apr 25;12(4):e7829. Epub 2020 Apr 25.

Internal Medicine, Citrus Memorial Hospital, Inverness, USA.

Rhodococcus equi (R. equi) is a rare zoonotic organism that is found in the feces of grazing animals and in farm soil. It typically causes pulmonary disease, but it can also cause extrapulmonary disease. Read More

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http://dx.doi.org/10.7759/cureus.7829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249752PMC

Clinicopathological and radiographic features in 40 cats diagnosed with pulmonary and cutaneous infection (2012-2018).

J Feline Med Surg 2019 Nov 14:1098612X19886395. Epub 2019 Nov 14.

Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Malaysia.

Objectives: This retrospective study aimed to describe clinical manifestations, diagnostic options, radiological features, therapeutic plans and outcomes for cats infected with .

Methods: Forty cats aged between 2 months and 11 years old (median 6 months) that were definitively diagnosed with rhodococcosis between 2012 and 2018 were recruited in this study. Medical records were reviewed for information on signalment, history, clinical presentation, diagnostic testing, treatment plans and clinical outcomes. Read More

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http://dx.doi.org/10.1177/1098612X19886395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206563PMC
November 2019

Conservation of (Magnusson 1923) Goodfellow and Alderson 1977 and rejection of (Morse 1912) Kämpfer et al. 2014.

Int J Syst Evol Microbiol 2020 May;70(5):3572-3576

UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland.

A recent taxonomic study confirmed the synonymy of (Magnusson 1923) Goodfellow and Alderson 1977 and (Morse 1912) Eberson 1918. As a result, both and were reclassified as comb. nov. Read More

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http://dx.doi.org/10.1099/ijsem.0.004090DOI Listing

Pulmonary Malakoplakia by in an HIV-Infected Patient in Mexico: A Case Report.

Case Rep Infect Dis 2020 6;2020:3131024. Epub 2020 Apr 6.

Department of Research of Infectious Diseases, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.

Background: -related pulmonary malakoplakia is a rare condition with few reported cases; hereby, we present a case associated with advanced human immunodeficiency virus (HIV) infection, and thus far to our knowledge, the first report in Mexico. It is estimated that approximately 10% of the infections occur in immunocompetent patients, whereas the rest are immune deficient, targeting virtually any organ. Histologically, malakoplakia is characterized by the buildup of infiltrated inflammatory tissue as a consequence of the gathering of histiocytes embedded with concentric inclusions. Read More

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http://dx.doi.org/10.1155/2020/3131024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166268PMC

The novel and transferable erm(51) gene confers macrolides, lincosamides and streptogramins B (MLS ) resistance to clonal Rhodococcus equi in the environment.

Environ Microbiol 2020 Apr 14. Epub 2020 Apr 14.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

The use of mass antimicrobial treatment has been linked to the emergence of antimicrobial resistance in human and animal pathogens. Using whole-genome single-molecule real-time (SMRT) sequencing, we characterized genomic variability of multidrug-resistant Rhodococcus equi isolated from soil samples from 100 farms endemic for R. equi infections in Kentucky. Read More

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http://dx.doi.org/10.1111/1462-2920.15020DOI Listing

The Oxidative Stress Markers of Horses-the Comparison with Other Animals and the Influence of Exercise and Disease.

Animals (Basel) 2020 Apr 3;10(4). Epub 2020 Apr 3.

Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.

Diacron-reactive oxygen metabolite (d-ROM) and biological antioxidant potential (BAP) levels in the serum of horses were measured (ponies, = 15; thoroughbred, = 31; other full-sized horses, = 7). The mean d-ROM levels in horses were significantly higher ( < 0.001) than those in dairy cattle ( = 25) and dogs ( = 31). Read More

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http://dx.doi.org/10.3390/ani10040617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222798PMC

Indications for the use of highest priority critically important antimicrobials in the veterinary sector.

J Antimicrob Chemother 2020 Jul;75(7):1671-1680

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870 Frederiksberg C, Denmark.

Background: Among the measures taken to preserve the clinical efficacy of highest priority critically important antimicrobials (HP-CIAs), the WHO has recommended avoiding their use in food-producing animals. Little is known regarding the indications for which different antimicrobial classes are used in animals, even in countries where data on antimicrobial use are available.

Objectives: To outline, in a narrative review, the diseases for which HP-CIAs are used in veterinary medicine, highlighting incongruences with international guidelines and disease conditions where effective alternatives to HP-CIAs are missing. Read More

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http://dx.doi.org/10.1093/jac/dkaa104DOI Listing

Horizontal Spread of Rhodococcus equi Macrolide Resistance Plasmid pRErm46 across Environmental .

Appl Environ Microbiol 2020 Apr 17;86(9). Epub 2020 Apr 17.

Microbial Pathogenesis Group, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom.

Conjugation is one of the main mechanisms involved in the spread and maintenance of antibiotic resistance in bacterial populations. We recently showed that the emerging macrolide resistance in the soilborne equine and zoonotic pathogen is conferred by the (46) gene carried on the 87-kb conjugative plasmid pRErm46. Here, we investigated the conjugal transferability of pRErm46 to 14 representative bacteria likely encountered by in the environmental habitat. Read More

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http://dx.doi.org/10.1128/AEM.00108-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170479PMC

The extracellular thioredoxin Etrx3 is required for macrophage infection in Rhodococcus equi.

Vet Res 2020 Mar 10;51(1):38. Epub 2020 Mar 10.

Department of Molecular Biology, Area of Microbiology, University of León, León, Spain.

Rhodococcus equi is an intracellular veterinary pathogen that is becoming resistant to current antibiotherapy. Genes involved in preserving redox homeostasis could be promising targets for the development of novel anti-infectives. Here, we studied the role of an extracellular thioredoxin (Etrx3/REQ_13520) in the resistance to phagocytosis. Read More

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http://dx.doi.org/10.1186/s13567-020-00763-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063783PMC

Isolation, characterisation, and genome sequencing of Rhodococcus equi: a novel strain producing chitin deacetylase.

Sci Rep 2020 Mar 9;10(1):4329. Epub 2020 Mar 9.

Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science & Technology), Ministry of Education, Tianjin Key Lab of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, P.R. China.

Chitin deacetylase (CDA) can hydrolyse the acetamido group of chitin polymers to produce chitosans, which are used in various fields including the biomedical and pharmaceutical industries, food production, agriculture, and water treatment. CDA represents a more environmentally-friendly and easier to control alternative to the chemical methods currently utilised to produce chitosans from chitin; however, the majority of identified CDAs display activity toward low-molecular-weight oligomers and are essentially inactive toward polymeric chitin or chitosans. Therefore, it is important to identify novel CDAs with activity toward polymeric chitin and chitosans. Read More

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http://dx.doi.org/10.1038/s41598-020-61349-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062688PMC

Comparing PFGE, MLST, and WGS in monitoring the spread of macrolide and rifampin resistant Rhodococcus equi in horse production.

Vet Microbiol 2020 Mar 28;242:108571. Epub 2019 Dec 28.

Department of Large Animal Medicine, University of Georgia, Athens 30605, USA.

Background: Rhodococcus equi (R. equi) infections are endemic in many horse facilities in the United States resulting significant economic loses annually. Currently, there is no commercial vaccine available and the emergence of isolates that are resistant to the current treatment and prophylaxis using antibiotics prompts closer surveillance of this pathogen. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.108571DOI Listing

Antimicrobial susceptibility patterns of Rhodococcus equi from necropsied foals with rhodococcosis.

Vet Microbiol 2020 Mar 7;242:108568. Epub 2020 Jan 7.

University of Kentucky, Veterinary Diagnostic Laboratory, 1490 Bull Lea Rd., Lexington, KY, 40513, USA.

Mainstay therapy for rhodococcosis in foals is the combination of rifampicin and a macrolide. While emergence of resistance to rifampicin and macrolides has been reported, studies demonstrating the development of resistance to such drugs is limited in necropsied foals with rhodococcosis. In this study, the foal necropsy records between 01/01/2011 and 08/30/2019 were reviewed for culture-positive R. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.108568DOI Listing

A Novel Screening Strategy Reveals ROS-Generating Antimicrobials That Act Synergistically against the Intracellular Veterinary Pathogen .

Antioxidants (Basel) 2020 Jan 28;9(2). Epub 2020 Jan 28.

Department of Molecular Biology, Area of Microbiology, University of León, 24071 León, Spain.

is a facultative intracellular pathogen that causes infections in foals and many other animals such as pigs, cattle, sheep, and goats. Antibiotic resistance is rapidly rising in horse farms, which makes ineffective current antibiotic treatments based on a combination of macrolides and rifampicin. Therefore, new therapeutic strategies are urgently needed to treat infections caused by antimicrobial resistant strains. Read More

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http://dx.doi.org/10.3390/antiox9020114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070597PMC
January 2020

Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals.

Front Vet Sci 2019 14;6:503. Epub 2020 Jan 14.

Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, United States.

The most common pathologic manifestation of , a gram-positive, facultative intracellular bacterium, is pyogranulomatous pneumonia in foals and weanlings. Hematogenous spread of bacteria may subsequently occur, resulting in joint sepsis, osteomyelitis, or subcutaneous abscessation. Medical records from horses presenting to the Cornell University Equine Hospital from 1998 to 2018 were reviewed for cases diagnosed with joint and/or bone infection, and information about case progression and outcome were analyzed. Read More

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http://dx.doi.org/10.3389/fvets.2019.00503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971166PMC
January 2020

A Common Practice of Widespread Antimicrobial Use in Horse Production Promotes Multi-Drug Resistance.

Sci Rep 2020 Jan 22;10(1):911. Epub 2020 Jan 22.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX, USA.

The practice of prophylactic administration of a macrolide antimicrobial with rifampin (MaR) to apparently healthy foals with pulmonary lesions identified by thoracic ultrasonography (i.e., subclinically pneumonic foals) is common in the United States. Read More

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http://dx.doi.org/10.1038/s41598-020-57479-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976650PMC
January 2020

Structural Determination of a New Peptidolipid Family from and the Pathogen by Multiple Stage Mass Spectrometry.

J Am Soc Mass Spectrom 2020 Mar 4;31(3):611-623. Epub 2020 Feb 4.

Institute for Cell Biology, University of Bonn, Ulrich-Haberland-Strasse 61a, 53121 Bonn, Germany.

The cell walls of the genus including the pathogenic bacterium () and biotechnologically important bacterium () contain an abundant eptidolipid (or termed lipopeptide) family whose structures have not been reported previously. Here, we describe a linear ion-trap multiple-stage mass spectrometric (LIT MS) approach with high resolution mass spectrometry (HRMS), in conjunction with NMR spectroscopy, chemical reactions, and GC/MS analysis to define the structures of these compounds. We employed LIT MS ( = 2-8) on the [M + Na] ion species to establish the peptide sequence, the identity of the fatty acyl substituent, and its location within the molecule, while NMR spectroscopy and GC/MS were used to recognize the Leu and Ile moieties. Read More

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http://dx.doi.org/10.1021/jasms.9b00059DOI Listing
March 2020
2.945 Impact Factor

Comparative Genomic Analysis of : An Insight into Genomic Diversity and Genome Evolution.

Int J Genomics 2019 18;2019:8987436. Epub 2019 Dec 18.

The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China.

, a member of the genus, is a gram-positive pathogenic bacterium. possesses an open pan-genome that constitutes the basis of its high genomic diversity and allows for adaptation to specific niche conditions and the changing host environments. Our analysis further showed that the core genome of contributes to the pathogenicity and niche adaptation of . Read More

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http://dx.doi.org/10.1155/2019/8987436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948317PMC
December 2019

Comment on "Rhodococcus equi Pneumonia in Kidney Transplant Recipient Affected by Acute Intermittent Porphyria: A Case Report".

Transplant Proc 2020 Jan - Feb;52(1):423-424. Epub 2020 Jan 3.

Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.transproceed.2019.10.005DOI Listing
January 2020

Dissolution and deacetylation of chitin in ionic liquid tetrabutylammonium hydroxide and its cascade reaction in enzyme treatment for chitin recycling.

Carbohydr Polym 2020 Feb 11;230:115605. Epub 2019 Nov 11.

Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science &Technology), Ministry of Education, Tianjin Key Lab of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, PR China. Electronic address:

Chitin is the second most abundant renewable polymer on earth, and its deacetylated derivative, chitosan, is a highly useful biopolymer. This work studied for the first time the application of ionic liquid (IL) tetrabutylammonium hydroxide ([TBA][OH]) and chitin deacetylase from Rhodococcus equi CGMCC14861 (ReCDA) for the efficient conversion of chitin into chitosan at room temperature. Results confirmed that chitin had good solubility in 18 wt% aqueous [TBA][OH] solution at 80 ℃. Read More

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http://dx.doi.org/10.1016/j.carbpol.2019.115605DOI Listing
February 2020

Phenotypic Characterization of Biofilm Grown and Inhibiting and Dissolving Activity of Azithromycin/Rifampicin Treatment.

Pathogens 2019 Dec 4;8(4). Epub 2019 Dec 4.

Department of Pharmaceutical Sciences, Biochemical Sciences and Health Section, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.

Microbial biofilm has been implicated in a wide range of chronic infections. In spite of the fact that is a recognized cause of chronic disease in animals and humans, few studies have focused on the sessile phenotype of . The aim of this research was to phenotypically characterize the biofilm development of and its answerability for hypo-responsiveness to macrolides and rifampicin. Read More

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http://dx.doi.org/10.3390/pathogens8040284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963269PMC
December 2019

Corrigendum to "Identification of macrolide- and rifampicin-resistant Rhodococcus equi in environmental samples from equine breeding farms in central Kentucky during 2018" [Vet. Microbiol. 232 (2019) 74-78].

Vet Microbiol 2020 Jan 4;240:108530. Epub 2019 Dec 4.

Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

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http://dx.doi.org/10.1016/j.vetmic.2019.108530DOI Listing
January 2020

Changing policy to treat foals with Rhodococcus equi pneumonia in the later course of disease decreases antimicrobial usage without increasing mortality rate.

Equine Vet J 2020 Jul 17;52(4):531-537. Epub 2020 Feb 17.

Large Animal Medicine, University of Georgia, Athens, Georgia, USA.

Background: There is a lack of data on the efficacy of treatment of Rhodococcus equi pneumonia in association with an optimised selection of foals.

Objectives: To evaluate whether targeted treatment protocols resulting in decreased antimicrobial use impact foal mortality rates.

Study Design: Retrospective study. Read More

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http://dx.doi.org/10.1111/evj.13219DOI Listing

GAPDH, rhbC, and vapA gene expression in Rhodococcus equi cultured under different iron concentrations.

Microb Pathog 2020 Feb 29;139:103885. Epub 2019 Nov 29.

Laboratório de Bacteriologia, Departamento de Medicina Veterinária Preventiva, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Camobi, Santa Maria, Rio Grande do Sul, 97105-900, Brazil.

The ability of Rhodococcus equi to survive in macrophages and cause pneumonia in foals depends on vapA and rhbC genes, which produce the virulence-associated protein A (VapA) and the rhequichelin siderophore, respectively. Virulent R. equi acquires Fe from transferrin by unknown mechanisms. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.103885DOI Listing
February 2020

Efficacy of the combination of doxycycline and azithromycin for the treatment of foals with mild to moderate bronchopneumonia.

Equine Vet J 2020 Jul 17;52(4):613-619. Epub 2020 Feb 17.

Veterinary Medical Center, University of Georgia, Athens, GA, USA.

Background: Given the importance of rifampin in treatment protocols for tuberculosis in people, its use in veterinary medicine is under increasing scrutiny in some countries and alternatives might be needed in the near future.

Objectives: This study was set up to evaluate whether azithromycin combined with doxycycline is effective for the treatment of bronchopneumonia in foals and noninferior to the combination of azithromycin and rifampin.

Study Design: This is a controlled, randomised and double-blinded clinical trial. Read More

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http://dx.doi.org/10.1111/evj.13211DOI Listing

Mycoredoxins Are Required for Redox Homeostasis and Intracellular Survival in the Actinobacterial Pathogen .

Antioxidants (Basel) 2019 Nov 15;8(11). Epub 2019 Nov 15.

Health Sciences Research Centre, University of Roehampton, London SW15 4JD, UK.

is a facultative intracellular pathogen that can survive within macrophages of a wide variety of hosts, including immunosuppressed humans. Current antibiotherapy is often ineffective, and novel therapeutic strategies are urgently needed to tackle infections caused by this pathogen. In this study, we identified three mycoredoxin-encoding genes () in the genome of , and we investigated their role in virulence. Read More

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http://dx.doi.org/10.3390/antiox8110558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912445PMC
November 2019

Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi.

mBio 2019 10 15;10(5). Epub 2019 Oct 15.

Microbial Pathogenesis Group, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, United Kingdom

Antibiotic use has been linked to changes in the population structure of human pathogens and the clonal expansion of multidrug-resistant (MDR) strains among healthcare- and community-acquired infections. Here we present a compelling example in a veterinary pathogen, , the causative agent of a severe pulmonary infection affecting foals worldwide. We show that the (46) gene responsible for emerging macrolide resistance among equine isolates in the United States is part of a 6. Read More

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http://dx.doi.org/10.1128/mBio.02260-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794481PMC
October 2019
1 Read

Strain-to-strain variation of Rhodococcus equi growth and biofilm formation in vitro.

BMC Res Notes 2019 Aug 19;12(1):519. Epub 2019 Aug 19.

Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA, USA.

Objective: Rhodococcus equi is an opportunistic pathogen that causes disease worldwide in young foals and immunocompromised humans. The interactions of R. equi with the host immune system have been described; however, most studies have been conducted using a few well-characterized strains. Read More

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http://dx.doi.org/10.1186/s13104-019-4560-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701102PMC

Cytological Findings in Bronchoalveolar Lavage Fluid of Foals With Pneumonia Caused by Rhodococcus equi and Other Bacteria.

J Equine Vet Sci 2019 08 18;79:9-12. Epub 2019 May 18.

Department of Veterinary Medicine, San Piero a Grado, PI, Italy. Electronic address:

The distinction between lower respiratory tract infections caused by Rhodococcus equi and those caused by other pathogens is difficult. The aim of this retrospective study was to describe cytological findings in bronchoalveolar lavage fluid (BALF) of foals with pneumonia caused by R. equi or other bacteria. Read More

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http://dx.doi.org/10.1016/j.jevs.2019.05.009DOI Listing
August 2019
3 Reads
0.871 Impact Factor

Transfusion With 2 L of Hyperimmune Plasma is Superior to Transfusion of 1 L or Less for Protecting Foals Against Subclinical Pneumonia Attributed to Rhodococcus equi.

J Equine Vet Sci 2019 08 22;79:54-58. Epub 2019 May 22.

Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX. Electronic address:

Transfusing foals with Rhodococcus equi hyperimmune plasma (REHIP) is a standard practice at many horse-breeding farms to help prevent R. equi pneumonia. At many large breeding farms, pneumonia is most commonly recognized as subclinical based on thoracic ultrasonography findings. Read More

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http://dx.doi.org/10.1016/j.jevs.2019.05.015DOI Listing

Prevalence and risk factors associated with emergence of Rhodococcus equi resistance to macrolides and rifampicin in horse-breeding farms in Kentucky, USA.

Vet Microbiol 2019 Aug 10;235:243-247. Epub 2019 Jul 10.

Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

The combination of a macrolide and rifampicin has been the mainstay of therapy in foals with Rhodococcus equi pneumonia for decades. Recent studies suggest that mass antimicrobial treatment of subclinically affected foals over time has selected for antimicrobial resistance. Our objective was to estimate the prevalence of R. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.07.010DOI Listing

First Microbiological and Molecular Identification of in Feces of Nondiarrheic Cats.

Biomed Res Int 2019 9;2019:4278598. Epub 2019 Jul 9.

Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, UNESP-São Paulo State University, Botucatu, SP, Brazil.

is responsible for infections in multiple-host animals. In humans, the prevalence of rhodococcus has increased worldwide and represents an emergent risk. is a soil-borne opportunistic bacterium isolated from feces of a wide variety of domestic species, except cats; thus, there is no known potential risk of its transmission from humans. Read More

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http://dx.doi.org/10.1155/2019/4278598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652081PMC
January 2020
2 Reads

Histoplasmosis and multicentric lymphoma in a Nubian goat.

J Vet Diagn Invest 2019 Sep 5;31(5):770-773. Epub 2019 Aug 5.

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX (Schlemmer, Fratzke, Porter, Mansell, Ploeg, Hoffmann, Older, Clark).

Following treatment for pneumonia, a 1-y-old female Nubian goat was presented because of a persistent fever for 3 mo and peripheral lymphadenopathy for 1 mo. Cytology and histology of the superficial cervical and prefemoral lymph nodes demonstrated a moderate-to-marked "left-shifted" lymphoid population, suggestive of lymphoma, and extremely rare extracellular, 2-4 µm, oval, basophilic yeast, consistent with . On immunohistochemistry, >95% of the lymphocytes demonstrated positive cytoplasmic and membranous immunoreactivity for CD3. Read More

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http://journals.sagepub.com/doi/10.1177/1040638719868810
Publisher Site
http://dx.doi.org/10.1177/1040638719868810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727113PMC
September 2019
3 Reads

sp. nov., a new actinobacterium isolated from a cave.

Int J Syst Evol Microbiol 2019 Oct;69(10):3128-3134

Department of Biological Sciences and Biotechnology, Hannam University, Daejon 34054, Republic of Korea.

A novel Gram-stain-positive actinobacterial strain, designated C9-28, was isolated from soil sampled in a natural cave on Jeju Island, Republic of Korea. Strain C9-28 morphologically exhibited a rod-coccus life cycle and grew at 10-37 °C (optimum, 30 °C), pH 6-9 (optimum, pH 7) and 0-3 % (optimum, absence of NaCl). In the maximum-likelihood tree based on 16S rRNA gene sequences, strain C9-28 formed a sublineage between a clade and the type strain of . Read More

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http://dx.doi.org/10.1099/ijsem.0.003601DOI Listing
October 2019
2 Reads

Ulcerative, granulomatous glossitis and enteritis caused by in a heifer.

J Vet Diagn Invest 2019 Sep 26;31(5):783-787. Epub 2019 Jul 26.

Veterinary Diagnostic Laboratory, Department of Veterinary Sciences, College of Agriculture Food & Environment, University of Kentucky, Lexington KY (Saied, Bolin).

infection in horses is common and is characterized by pyogranulomatous pneumonia and ulcerative enterocolitis. clinical disease in cattle, however, is rare and typically manifests as granulomatous lymphadenitis discovered in the abattoir. A 19-mo-old female Santa Gertrudis had a history of intermittent inappetence and weight loss for a 3-mo period before euthanasia. Read More

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http://dx.doi.org/10.1177/1040638719867120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727123PMC
September 2019
4 Reads

Effect of Macrolide and Rifampin Resistance on Fitness of during Intramacrophage Replication and .

Infect Immun 2019 10 19;87(10). Epub 2019 Sep 19.

Department of Large Animal Medicine, University of Georgia, Athens, Georgia, USA.

The soil-dwelling, saprophytic actinomycete is a facultative intracellular pathogen of macrophages and causes severe bronchopneumonia when inhaled by susceptible foals. Standard treatment for disease is dual-antimicrobial therapy with a macrolide and rifampin. Thoracic ultrasonography and early treatment with antimicrobials prior to the development of clinical signs are used as means of controlling endemic infection on many farms. Read More

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http://dx.doi.org/10.1128/IAI.00281-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759311PMC
October 2019
1 Read

Genomic analysis of a novel Rhodococcus (Prescottella) equi isolate from a bovine host.

Arch Microbiol 2019 Nov 13;201(9):1317-1321. Epub 2019 Jul 13.

Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.

Rhodococcus (Prescottella) equi causes pneumonia-like infections in foals with high mortality rates and can also infect a number of other animals. R. equi is also emerging as an opportunistic human pathogen. Read More

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http://dx.doi.org/10.1007/s00203-019-01695-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790187PMC
November 2019

Treatment and prevention of in foals.

Authors:
Lucjan Witkowski

Vet Rec 2019 07;185(1):16-18

Laboratory of Veterinary Epidemiology and Economics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Warsaw, Poland.

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http://dx.doi.org/10.1136/vr.l4505DOI Listing
July 2019
1 Read

Pyogranulomatous enteritis and mesenteric lymphadenitis in an adult llama caused by carrying virulence-associated protein A gene.

J Vet Diagn Invest 2019 Sep 5;31(5):747-751. Epub 2019 Jul 5.

Oregon Veterinary Diagnostic Laboratory, Departments of Biomedical Sciences (Löhr, O'Neill).

We report herein infection in an 11-y-old, male llama with a history of diarrhea and endoparasitism. Postmortem examination revealed granulomatous and ulcerative enteritis, pyogranulomatous mesenteric lymphadenitis, fibrinosuppurative peritonitis, and granulomatous hepatitis. Intralesional macrophages were laden with gram-positive cocci. Read More

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http://journals.sagepub.com/doi/10.1177/1040638719862834
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http://dx.doi.org/10.1177/1040638719862834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727108PMC
September 2019
3 Reads

[Pseudo-tumor lesions induced by infectious agents. Case no. 7].

Ann Pathol 2019 Aug 26;39(4):274-276. Epub 2019 Jun 26.

Service de chirurgie thoracique, hôpital Pasteur, FHU OncoAge, université Côte d'Azur, CHU de Nice, 30, voie Romaine, 06000 Nice, France.

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http://dx.doi.org/10.1016/j.annpat.2019.04.006DOI Listing
August 2019
1 Read

The pathogenic actinobacterium Rhodococcus equi: what's in a name?

Mol Microbiol 2019 07 17;112(1):1-15. Epub 2019 Jun 17.

UCD School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland.

Rhodococcus equi is the only recognized animal pathogenic species within an extended genus of metabolically versatile Actinobacteria of considerable biotechnological interest. Best known as a horse pathogen, R. equi is commonly isolated from other animal species, particularly pigs and ruminants, and causes severe opportunistic infections in people. Read More

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http://dx.doi.org/10.1111/mmi.14267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852188PMC
July 2019
6 Reads

In vitro evaluation of complement deposition and opsonophagocytic killing of Rhodococcus equi mediated by poly-N-acetyl glucosamine hyperimmune plasma compared to commercial plasma products.

J Vet Intern Med 2019 May 29;33(3):1493-1499. Epub 2019 Apr 29.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas.

Background: The bacterium Rhodococcus equi can cause severe pneumonia in foals. The absence of a licensed vaccine and limited effectiveness of commercial R. equi hyperimmune plasma (RE-HIP) create a great need for improved prevention of this disease. Read More

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http://dx.doi.org/10.1111/jvim.15511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524092PMC
May 2019
6 Reads

Identification of macrolide- and rifampicin-resistant Rhodococcus equi in environmental samples from equine breeding farms in central Kentucky during 2018.

Vet Microbiol 2019 May 6;232:74-78. Epub 2019 Apr 6.

Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Rhodococcus equi causes severe pneumonia in foals and is most often recognized in people as an opportunistic pathogen. Longitudinal studies examining antimicrobial-resistant R. equi from environmental samples are lacking. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.04.008DOI Listing
May 2019
3 Reads

-specific hyperimmune plasma administration decreases faecal shedding of pathogenic in foals.

Vet Rec 2019 07 17;185(1):19. Epub 2019 Apr 17.

Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.

is the most common cause of pneumonia in young foals. Pneumonic foals are an important source of environmental contamination as they shed higher amounts of in their faeces than unaffected foals. As -specific hyperimmune plasma (HIP) lessens clinical pneumonia, we hypothesise that its use would result in decreased faecal shedding of by foals. Read More

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http://veterinaryrecord.bmj.com/lookup/doi/10.1136/vr.105327
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http://dx.doi.org/10.1136/vr.105327DOI Listing
July 2019
25 Reads

Foal-Level Risk Factors Associated With Development of Rhodococcus equi Pneumonia at a Quarter Horse Breeding Farm.

J Equine Vet Sci 2019 01 3;72:89-96. Epub 2018 Nov 3.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX.

The occurrence of Rhodococcus equi at farms varies, with disease occurring endemically at some farms, but only sporadically, or not at all at other farms. Only some foals residing on endemic farms develop clinical signs of disease. Limited evidence is available regarding foal-level risk factors for the development of R. Read More

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http://dx.doi.org/10.1016/j.jevs.2018.10.023DOI Listing
January 2019
19 Reads

In vitro antimicrobial susceptibility of equine clinical isolates from France, 2006-2016.

J Glob Antimicrob Resist 2019 12 15;19:144-153. Epub 2019 Mar 15.

LABÉO Frank Duncombe, 14053 Caen, France; Normandie Univ, UNICAEN, U2RM, 14033 Caen, France. Electronic address:

Objectives: This study aimed to analyse antimicrobial susceptibility evolution of equine pathogens isolated from clinical samples from 2006-2016.

Methods: A collection of 25 813 bacterial isolates was studied, clustered according to their origins (respiratory tract, cutaneous, genital and other), and analysed for their antimicrobial susceptibility using the disk diffusion method.

Results: The most frequently isolated pathogens were group C Streptococci (27. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.03.006DOI Listing
December 2019
6 Reads

Influence of bioaugmentation and biostimulation on PAH degradation in aged contaminated soils: Response and dynamics of the bacterial community.

J Environ Manage 2019 May 4;238:49-58. Epub 2019 Mar 4.

School of Science, RMIT University, Bundoora, Melbourne, VIC, 3083, Australia; Centre for Environmental Sustainability and Remediation, RMIT University, Bundoora, Melbourne, VIC, 3083, Australia. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) represent a group of hazardous compounds that are ubiquitous and persistent. The main aim of this study was to investigate the degradation of PAHs in chronically contaminated, aged and weathered soils obtained from a former gas plant of Australia. Biostimulation and bioaugmentation using individual isolates (Rhodococcus sp. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.115DOI Listing
May 2019
6 Reads

Rhodococcus equi pVAPN type causing pneumonia in a dog coinfected with canine morbillivirus (distemper virus) and Toxoplasma gondii.

Microb Pathog 2019 Apr 6;129:112-117. Epub 2019 Feb 6.

UNESP-São Paulo State University, Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Sciences, Botucatu, State of São Paulo, Brazil. Electronic address:

Canine morbillivirus (previously, canine distemper virus, CDV) is a highly contagious infectious disease-causing agent that produces immunosuppressive infections and multiple clinical signs. Canine toxoplasmosis is an opportunistic disease characterized by enteric, pulmonary, and neuromuscular signs that might be confused with CDV-induced infections. Rhodococcus equi is a Gram-positive intracellular facultative bacterium that is also opportunistic in nature, and causes pyogranulomatous infections in humans and multiple host animals, although canine rhodococcosis is rare or unrecognized. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.01.048DOI Listing
April 2019
8 Reads

Ophthalmologic findings associated with Rhodococcus equi bronchopneumonia in foals.

Vet Ophthalmol 2019 Sep 31;22(5):660-665. Epub 2019 Jan 31.

Departament de Medicina i Cirurgia Animal, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: To describe ocular findings associated with Rhodococcus equi bronchopneumonia in foals, and to determine whether severity of the ocular lesions is related with outcome.

Animals Studied: Foals diagnosed with R equi infection at the VTH-UAB from January 2002 to December 2017.

Procedure: Rhodococcus equi infection was diagnosed by means of clinical signs, radiographic/ultrasonographic findings, and/or positive culture. Read More

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http://dx.doi.org/10.1111/vop.12637DOI Listing
September 2019
5 Reads

PNAG-specific equine IgG mediates significantly greater opsonization and killing of Prescottella equi (formerly Rhodococcus equi) than does IgG.

Vaccine 2019 02 26;37(9):1142-1150. Epub 2019 Jan 26.

College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, 660 Raymond Stotzer Pkwy, College Station, TX 77843-4475, United States. Electronic address:

Prescottella equi (formerly Rhodococcus equi) is a facultative intracellular bacterial pathogen that causes severe pneumonia in foals 1-6 months of age, whereas adult horses are highly resistant to infection. We have shown that vaccinating pregnant mares against the conserved surface polysaccharide capsule, β-1 → 6-linked poly-N-acetyl glucosamine (PNAG), elicits opsonic killing antibody that transfers via colostrum to foals and protects them against experimental infection with virulent. R. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.028DOI Listing
February 2019
8 Reads