2,264 results match your criteria Rhinology[Journal]


Novel roles for nasal epithelium in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Rhinology 2018 Dec 1. Epub 2018 Dec 1.

Otorhinolaryngology, Academic Medical Center, Amsterdam, the Netherlands.

Background: Airway epithelial cells have a well-accepted role in the regulation of local inflammatory processes in allergic and innate defence responses. However, their role the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) is unclear. The objective was to investigate whether potential differences in the mRNA expression profile of nasal epithelia from healthy individuals and from CRSwNP patients would shed new light on disease mechanisms. Read More

View Article
December 2018

Topographical distribution of trigeminal receptor expression in the nasal cavity.

Rhinology 2018 Nov 29. Epub 2018 Nov 29.

Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.

Background: Topographical differences in trigeminal receptor distribution of the nasal cavity has been investigated so far indirectly using various agonists to stimulate receptors in different locations. However, polymodal activation of trigeminal receptors poses difficulties in such investigation. The aim of our study was to examine the distribution of trigeminal receptor mRNA expression using quantitative PCR. Read More

View Article
November 2018

Similar survival outcome after endoscopic and open approaches for sinonasal mucosal melanoma.

Rhinology 2018 Nov 24. Epub 2018 Nov 24.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: To describe a cohort of sinonasal mucosal melanoma (SNMM) patients, and to assess if choice of surgical approach (open versus endoscopic) has impact on survival.

Methodology: Adequate data on clinical presentation, treatment, and recurrence pattern were available for 58 consecutive patients treated for SNMM at the Helsinki University Hospital (HUH) between 1983 and 2016.

Results: The 5-year disease-specific survival (DSS) was 27% and overall survival 25% for the whole cohort. Read More

View Article
November 2018
5 Reads

Clinical efficacy of intranasal drug delivery by nebulization in chronic rhinosinusitis: a systematic review.

Rhinology 2018 Nov 24. Epub 2018 Nov 24.

Service d'Oto-rhino-laryngologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.

Background: Treatment of chronic rhinosinusitis (CRS) aims to treat the underlying inflammation or infection. Although the optimal modality of administration remains controversial, inhalation route is usually preferred. The aim of this systematic review was to summarize the efficacy of intranasal corticoisteroids or antibiotics delivery by nebulization on symptoms, histology, endoscopy scores, nasal obstruction, clinical outcomes and quality of life in CRS. Read More

View Article
November 2018
1 Read

Lack of correlation between serum 25(OH)D level and endoscopy-based chronic rhinosinusitis in Korean adults.

Rhinology 2018 Nov 24. Epub 2018 Nov 24.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.

Background: Several previous studies have shown that serum 25(OH)D deficiency is associated with increased risk of chronic rhinosinusitis (CRS) in adults and also correlated with disease severity. We aimed to investigate the correlation between serum 25(OH)D level and endoscopy-based CRS in adults using the Korean National Health and Nutrition Examination Survey.

Methods: The data were based on the Korean National Health and Nutrition Examination Survey from 2008 to 2011. Read More

View Article
November 2018
1 Read

From prevention to optimal treatment in chronic rhinosinusitis.

Authors:
P W Hellings

Rhinology 2018 Oct 27. Epub 2018 Oct 27.

Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, Euforea, Brussels, Belgium.

Prevention of chronic rhinosinusitis remains a true societal challenge, as prevention of this highly prevalent non-communicable disease will significantly reduce socio-economic costs and improve the overall well-being of the large group of affected individuals. In alignment with the health priorities of national governments, prevention and cost-effective health care should be embraced by the Rhinologic community. Read More

View Article
October 2018
3 Reads

Propofol sedation in Drug Induced Sedation Endoscopy without an anaesthesiologist - a study of safety and feasibility.

Rhinology 2018 Oct 26. Epub 2018 Oct 26.

Department of ORL, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Propofol sedation in Drug Induced Sedation Endoscopy (DISE) of the upper airway of patients with obstructive sleep apnea (OSA) without the presence of anesthesiologist has not been done before. Propofol sedation is normally administered by an anesthesiologist. This is the first study of this new method. Read More

View Article
October 2018
5 Reads

Radiologic changes in the aging nasal cavity.

Rhinology 2018 Dec 1. Epub 2018 Dec 1.

Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC United States.

Background: With an aging population, it is important to understand age-related anatomic changes in the nasal cavity and cribriform plate (CP) that may have clinical implications.

Methodology: Computed tomography (CT) scans obtained for non-rhinologic conditions were divided into a young cohort (N=35, 18-34 years old) and an older adult cohort (N=32, 80-99 years old). Intranasal airspace volumes and bony anatomy of the CP were manually segmented using OsiriX software. Read More

View Article
December 2018
2 Reads

Fibrin tissue adhesive versus nasal packing in endoscopic nasal surgery: a systematic review and meta-analysis.

Rhinology 2018 Sep 17. Epub 2018 Sep 17.

Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom.

Background: It has been proposed that fibrin tissue adhesive (FTA) can act as an effective alternative to nasal packing in managing the postoperative symptoms of endoscopic nasal surgery.

Methodology: MEDLINE, Embase, Cochrane Library, The Cumulative Index to Nursing and Allied Health Literature and ClinicalTrials.gov were searched for randomised controlled trials comparing FTA with nasal packing in endoscopic nasal surgery. Read More

View Article
September 2018

Local specific Immunoglobulin E among patients with nonallergic rhinitis: a systematic review.

Rhinology 2018 Oct 23. Epub 2018 Oct 23.

Rhinology and Skull Base Research Group, St Vincents Centre for Applied Medical Research, University of New South Wales, Sydney, Australia; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Background: Allergen specific immunoglobulin can be present in the nasal mucosa of patients with non-allergic rhinitis (NAR). This condition is defined as local allergic rhinitis. However, the reported presence of nasal specific immunoglobulin E (nspIgE) among NAR is variable. Read More

View Article
October 2018

Delivering better results for patients through core outcomes, measuring evidence and patient participation.

Authors:
W J Fokkens

Rhinology 2018 Sep;56(3):193-194

Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands.

Nasal obstruction is one of the most frequent and bothersome symptoms in rhinosinal disease. Although we are able to measure nasal airflow, the correlation between the feeling of nasal obstruction and objective measurements has been shown to be average at most. A significant proportion of the European population has a more or less deviated nasal septum and deviated septa have received a lot of attention from otorhinolaryngologists. Read More

View Article
September 2018
1 Read

Responsiveness and minimal clinically important difference for the EQ-5D in chronic rhinosinusitis.

Rhinology 2018 Sep 3. Epub 2018 Sep 3.

Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.

Background: The 5-dimensional EuroQol questionnaire (EQ-5D) is validated to measure general health-related quality of life (QOL). Our objective was to determine the responsiveness and minimal clinically important difference (MCID) of the EQ-5D health utility value (EQ-5D HUV) and visual analog scale (EQ-5D VAS) in chronic rhinosinusitis (CRS).

Methods: 203 adults undergoing medical management for CRS were prospectively recruited. Read More

View Article
September 2018

Entering a new era of Predictive Medicine in Rhinology.

Authors:
P W Hellings

Rhinology 2018 Jun;56(2):97-98

Clinical Division of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.

The June 2018 issue of Rhinology paves the way for real-life implementation of Precision Medicine in Rhinology, with Predictive Medicine in the center of attention. Physicians treating patients with rhinologic disorders might find it extremely interesting to find reports on predictors of success of medical or surgical interventions. Prediction of success of treatment is crucial to allow the patient become an active partner in the decision-making process of medical or surgical treatment. Read More

View Article
June 2018
6 Reads

Comparison of efficacy of fluticasone propionate versus clarithromycin for postoperative treatment of different phenotypic chronic rhinosinusitis: a randomized controlled trial.

Rhinology 2018 Aug 23. Epub 2018 Aug 23.

Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Chronic rhinosinusitis (CRS) can be divided to CRS without nasal polyps (CRSsNP) and eosinophilic and non-eosinophilic CRS with nasal polyps (CRSwNP). There is little evidence on the efficacy of glucocorticoids and macrolides in different phenotypic patients. The aim of this study was to compare the benefit of glucocorticoids and macrolides following endoscopic sinus surgery (ESS) in different phenotypic CRS. Read More

View Article

Primary surgical treatment of nasal vestibule cancer - therapeutic outcome and reconstructive strategies.

Rhinology 2018 Aug 15. Epub 2018 Aug 15.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Ruprecht-Karls-University Heidelberg, Germany.

Objective: The treatment strategy of squamous cell carcinoma of the nasal vestibule (SCCNV) is controversial. The objective of this study is to investigate the role of surgery, which is the preferred treatment option at our institution.

Design: This was a monocentric prospective study of patients that were diagnosed with SCCNV between 2005 and 2013. Read More

View Article
August 2018
1 Read

Medication use in patients with chronic rhinosinusitis in Germany - a large retrospective patient-based study.

Rhinology 2018 Aug 7. Epub 2018 Aug 7.

Epidemiology, IQVIA, Frankfurt, Germany.

Background: The aim of the present study was to provide an insight into medical treatment practices among patients with chronic rhinosinusitis (CRS) in Germany. An investigation of ICD codes and ATC classes of CRS patients in general and otolaryngology offices in Germany should reveal the prevalent treatment behaviors of German physicians.

Methods: The present study used data from the Disease Analyzer database (IQVIA). Read More

View Article
August 2018
11 Reads

Olfactory training changes electrophysiological responses at the level of the olfactory epithelium.

Rhinology 2018 Aug 4. Epub 2018 Aug 4.

Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.

Background: Olfactory training (OT) has been shown to increase olfactory performance in healthy subjects and patients with post-traumatic or post-infectious olfactory loss. Morphological correlates such as olfactory bulb volume increase and gray matter changes suggest central changes in olfactory brain areas following olfactory exposure. Some evidence from animal studies indicates peripheral changes upon OT whereas no such data exist in humans. Read More

View Article

Rhinology future trends: 2017 EUFOREA debate on allergic rhinitis.

Rhinology 2018 Jul 27. Epub 2018 Jul 27.

Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK.

The 2nd Rhinology Future Debate, organized by EUFOREA (European Forum for Research and Education in Allergy and Airways diseases) was held in Brussels in December 2017. One of these debates addressed the position of MP-AzeFlu in allergic rhinitis (AR) treatment. The current article summarizes this debate; reviewing recent data, and exploring how this has been interpreted by experts and incorporated into AR management guidelines and a clinical decision support system (CDSS). Read More

View Article
July 2018
3 Reads

The clinical implications of computerised fluid dynamic modelling in rhinology.

Rhinology 2018 Jul 27. Epub 2018 Jul 27.

Department of Surgery, The University of Auckland, Auckland, New Zealand.

Background: The nose is a dynamic organ and is the first point of contact between inhaled air and mucosal surfaces. Within the nasal cavity, there are changes of air flow and pressure occurring during the respiratory cycle, as well as exchanges of heat and humidity, and important immune responses to inhaled antigens and allergens.

Methodology: This review is a summary for rhinologists covering what is known about airflow within the nose and sinuses and the impact of pathology and treatments on the physical environment of the nasal cavity. Read More

View Article
July 2018
7 Reads

Prevention of chronic rhinosinusitis.

Rhinology 2018 Jul 27. Epub 2018 Jul 27.

Department of Otorhinolaryngology, Head and Neck Surgery University Hospitals Leuven, Belgium.

Prevention of chronicity of disease and minimising its impact with individualized treatment is a fundamental tenet of precision medicine. A review of the literature has been undertaken to explore how this may apply to chronic rhinosinusitis (CRS). Prevention may be thought of across 3 main domains. Read More

View Article
July 2018
11 Reads

Quality of life after nasal cancer resection - surgical versus prosthetic rehabilitation.

Rhinology 2018 Jul 27. Epub 2018 Jul 27.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Ruprecht-Karls-University Heidelberg, Germany.

Background: Nose reconstruction following resection of nasal carcinomas is controversial. The objective of this study is to investigate the effect of surgical reconstruction versus prosthetic rehabilitation on patient quality of life (QOL).

Design: This was a monocentric prospective study of patients diagnosed with nasal carcinoma from 2003 to 2013. Read More

View Article

Chitosan films promote formation of olfactory neurospheres and differentiation of olfactory receptor neurons.

Rhinology 2018 Jul 27. Epub 2018 Jul 27.

Department of Electrical Engineering, College of Electrical and Communication Engineering, Yuan Ze University, Taoyuan, Taiwan.

Background: Olfactory dysfunction significantly impairs the life quality of patients. Therefore, a model needs to be developed for anosmia. Chitosan is a biodegradable natural polysaccharide that has been widely studied for regenerative purposes in the nervous system. Read More

View Article

Chronic rhinosinusitis exacerbations are differentially associated with lost productivity based on asthma status.

Rhinology 2018 Jul 25. Epub 2018 Jul 25.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

Background: The frequency of chronic rhinosinusitis (CRS) exacerbations is an independent predictor of quality of life. The objective of this study was to evaluate if increased CRS exacerbations predict decreased productivity.

Methods: Cross-sectional study of adult CRS patients. Read More

View Article

Modified nasal floor and inferior meatus flap for septal perforation repair. Extension and limits.

Rhinology 2018 Jul 21. Epub 2018 Jul 21.

Rhinology and Skull Base Unit, Department of Otorhinolaryngology, Hospital Clinic, Universitat de Barcelona, Spain.

Background: The nasal floor and inferior meatus (NFIM) flap represents an available option for the reconstruction of a septal perforation (SP). This study explores the feasibility of repairing SPs using a modified simple and extended (including inferior turbinate) NFIM flap.

Methods: An anatomic study was achieved in fresh frozen cadaveric specimens to measure the area and lengths of NFIM flap. Read More

View Article

Histopathological features of antrochoanal polyps in Chinese patients.

Rhinology 2018 Jul 21. Epub 2018 Jul 21.

Department of Otolaryngology, National University of Singapore, National University Health System, Singapore, Singapore.

Background: The pathogenesis and etiology of antrochoanal polyps (ACP) are unclear. The aim of this study is to characterize the features of inflammatory cellular infiltration, the epithelial remodeling patterns and their associations to clinical parameters in ACP.

Methods: A detailed histological study employing classic immunohistochemistry was performed. Read More

View Article

Epidemiology of chronic rhinosinusitis in Bushehr, southwestern region of Iran: a GA2LEN study.

Rhinology 2018 Jul 21. Epub 2018 Jul 21.

Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.

Background: Population-based studies using the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) criteria for the assessment of the chronic rhinosinusitis (CRS) prevalence play important roles in the development and promotion of public health policies.

Methods: A multistage, stratified cluster, random sampling method was used to select the study participants from individuals living in Bushehr, which is in the southwestern part of Iran. The standardized Global Allergy and Asthma European Network (GA2LEN) questionnaire was completed by 5,201 participants, and the CRS prevalence were compared among different groups of related factors using chi-squared tests. Read More

View Article

Sinonasal inverted papilloma recurrence rates and evaluation of current staging systems.

Rhinology 2018 Jul 21. Epub 2018 Jul 21.

Division of Otolaryngology, University of British Columbia, St. Pauls Sinus Centre, Vancouver, British Columbia, Canada.

Background: Sinonasal inverted papillomas (SNIPs) are benign epithelial growths with high recurrence rates after surgical management. This study aims to evaluate SNIP recurrence rates after endoscopic surgery and to provide a comparison of published staging systems.

Methods: This chart review evaluated primary and revision SNIP cases from January 2008 to December 2016 at a tertiary sinus centre. Read More

View Article
July 2018
4 Reads

Influence of number of drugs on olfaction in the elderly.

Rhinology 2018 Jun 25. Epub 2018 Jun 25.

Department of Neurosciences, Otolaryngology Section, University of Padova, Padova, Italy.

Background: The etiology of age-related olfactory loss is still unclear, but it has been claimed that polypharmacotherapy may contribute to olfactory dysfunction, particularly in the elderly, who are more likely to need multiple drugs. The present pilot study investigated the relationship between smell and the number and type of drugs taken in a group of elderly.

Methodology: 50 elderly volunteers (over 64 years old) who were healthy from the sinonasal standpoint (SNOT-22 under 1) and had no cognitive impairments [Mini Mental State Examination (MMSE over 18) were administered the Screening 12 test and tested on their n-butanol olfactory threshold. Read More

View Article
June 2018
5 Reads

The Global Allergy and Asthma European Network (GALEN rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps.

Rhinology 2018 Jun 17. Epub 2018 Jun 17.

Ghent University, Ghent, Belgium.

Background: Chronic rhinosinusitis (CRS) is a common yet under-recognised chronic inflammatory disease of the nose and paranasal sinuses that is classified according to the presence (CRSwNP) or absence (CRSsNP) of nasal polyps.

Methods: This paper reports the methodology and descriptive results of the Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort. We established a large CRS cohort within the GALEN consortium (European FP6 research initiative) to identify inflammatory endotypes, the natural disease course, and its impact on health-related quality of life (HRQoL). Read More

View Article
June 2018
13 Reads

TSLP regulates eotaxin-1 production by nasal epithelial cells from patients with eosinophilic CRSwNP.

Rhinology 2018 Jun 17. Epub 2018 Jun 17.

Schools of Medicine and Nursing Sciences, Huzhou University Location: No.759, Huzhou City, Zhejiang Prov, China.

Background: Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by Th2-skewed inflammation with eosinophilic infiltration. Thymic stromal lymphopoietin (TSLP) promotes the development of allergic inflammation. Although increased TSLP is found in eCRSwNP, little is known about whether TSLP regulates eotaxin-1 production, a potent eosinophil chemoattractant that recruits and activates eosinophils. Read More

View Article

The effect of the titanium butterfly implant on nasal patency and quality of life.

Rhinology 2018 Jun 11. Epub 2018 Jun 11.

Departement of Otorhinolaryngology, Radboudumc Nijmegen, the Netherlands.

Objective: The titanium butterfly implant seems to be a powerful technique to repair nasal valve insufficiency. However, the effect of these implants on nasal patency and quality of life has been controversial due to a lack of evidence. The purpose of this study is to evaluate the objective and subjective effect of the titanium butterfly implant on nasal patency and corresponding quality of life. Read More

View Article
June 2018
1 Read

Topical nasal decongestant oxymetazoline (0.05%) provides relief of nasal symptoms for 12 hours.

Rhinology 2018 May 22. Epub 2018 May 22.

Procter and Gamble, Cincinnati, OH 45221, USA.

Background: Nasal congestion, often referred to as stuffy nose or blocked nose is one of the most prevalent and bothersome symptoms of an upper respiratory tract infection. Oxymetazoline, a widely used intranasal decongestant, offers fast symptom relief, but little is known about the duration of effect.

Methodology: The results of 2 randomized, double-blind, vehicle-controlled, single-dose, parallel, clinical studies (Study 1, n=67; Study 2, n=61) in which the efficacy of an oxymetazoline (0. Read More

View Article
May 2018
3 Reads

Multivariate analysis of inflammatory endotypes in recurrent nasal polyposis in a Chinese population.

Rhinology 2018 Sep;56(3):216-226

ENT Department, West China Hospital, Sichuan University, Chengdu, China.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical problem due to its propensity for recurrence. However, data on the frequency of CRSwNP recurrence after surgery in China are rare.

Methods: 78 CRSwNP patients undergoing functional endoscopic sinus surgery were followed-up for 8 years and classified into recurrent and non-recurrent groups. Read More

View Article
September 2018

Horizontal lateral lamella as a risk factor for iatrogenic cerebrospinal fluid leak. Clinical retrospective evaluation of 24 cases.

Rhinology 2018 May 22. Epub 2018 May 22.

Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.

Background: Several authors highlighted the limitations of the Keros classification system in predicting intracranial entry risk. Recently, our group proposed a new classification system based on the angle formed between the lateral lamella of the cribriform plate (LLCP) and the continuation of an horizontal plane passing through the cribriform plate (Gera classification). The aim of this study was to analyze whether the risk of iatrogenic cerebrospinal fluid leak (CSF-L) was better predicted by Keros or Gera classification. Read More

View Article

Correlation between Excessive Daytime Sleepiness (EDS) and self-reported and objective nasal characteristics.

Rhinology 2018 Apr 25. Epub 2018 Apr 25.

Department of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, 5021 Bergen Norway.

Background: The aim of the present study was to explore the relationship between excessive daytime sleepiness (EDS), Peak Nasal Inspiratory Flow (PNIF), and patient reported symptoms from the nose.

Methology: Six hundred and fifty one consecutive patients referred to a hospital on suspicion of sleep related breathing disorder (SRBD) were included in the study. Daytime sleepiness was assessed by Epworth Sleepiness Scale (EpSS). Read More

View Article

Septoplasty for nasal obstruction due to a deviated nasal septum in adults: a systematic review.

Rhinology 2018 Sep;56(3):195-208

Department of Otorhinolaryngology, Radboud Institute for Health Sciences, Radboud university medical center Nijmegen, the Netherlands.

Background: The status of current evidence for the effectiveness of septoplasty is unclear. This systematic review evaluates the effectiveness of a) septoplasty (with or without concurrent turbinate surgery) versus non-surgical management, and b) septoplasty with concurrent turbinate surgery versus septoplasty alone, for nasal obstruction due to a deviated nasal septum in adults.

Methodology: Eligible for inclusion were randomised controlled trials and non-randomised designs comparing treatment strategies. Read More

View Article
September 2018
2 Reads

Self-reported anxiety and depression unchanged after endoscopic sinus surgery for chronic rhinosinusitis.

Rhinology 2018 Sep;56(3):234-240

Department of Otolaryngology, Head and Neck Surgery, University of North Carolina at Chapel Hill, NC, USA.

Background: Prior research has established that anxiety and depression, as measured by the Hospital Anxiety Depression Score (HADS), are strongly correlated with disease-specific quality of life (Rhinosinusitis Disability Index - RSDI) in chronic rhinosinusitis (CRS). We hypothesized that anxiety and depression would decrease after functional endoscopic sinus surgery (FESS), and furthermore that HADS would predict improvement in RSDI following surgery.

Methodology: The study cohort from 2014 consisted of 99 CRS patients who underwent nasal endoscopy, RSDI, and HADS evaluation. Read More

View Article
September 2018

The presence of Interleukin-13 in nasal lavage may be a predictor of nasal polyposis in pediatric patients with cystic fibrosis.

Rhinology 2018 Sep;56(3):261-267

Division of Pediatric Otolaryngology-Head and Neck Surgery, B.C. Childrens Hospital, Vancouver, British Columbia, Canada.

Background: Sinonasal disease is a common feature of cystic fibrosis (CF) and can cause significant morbidity in these patients. Our objective was to determine if CF individuals with concomitant nasal polyposis (NP) express a unique profile of inflammation and if so, whether these inflammatory cytokine mediators have predictive value in identifying these individuals for prompt management by an Otolaryngologist.

Methodology: Nasal lavage samples and clinical outcomes of disease severity were obtained from thirty-eight pediatric CF individuals. Read More

View Article
September 2018
1 Read

Nasal symptoms, epithelial injury and neurogenic inflammation in elite swimmers.

Rhinology 2018 Sep;56(3):279-287

Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.

Background: A high burden of lower airway symptoms is found in elite swimmers. To what extent elite swimmers suffer from upper airway symptoms and how these associate with nasal inflammation is less clear. We here aimed to evaluate upper airway symptoms and nasal inflammation in elite athletes. Read More

View Article
September 2018
1 Read

The symptom burden of autonomic dysfunction is positively associated with chronic rhinosinusitis status.

Rhinology 2018 Sep;56(3):227-233

Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Dysregulation of the autonomic system can affect sinonasal physiological function and may exacerbate the symptom burden associated with rhinosinusitis. However, the association between autonomic dysfunction and chronic rhinosinusitis (CRS) has seldom been studied. Here, we investigated the relationship between autonomic dysfunction and CRS. Read More

View Article
September 2018
2 Reads

Reconstruction of frontal defects with calvarial grafts.

Rhinology 2018 Sep;56(3):297-302

Department of Otolaryngology-Head and Neck Surgery, AHEPA Hospital, Aristotle University of Thessaloniki, Greece.

Background: There are many options for the reconstruction of frontal sinus wall defect resulting from injury, neoplastic lesions and aesthetic deformities. These mainly include autogenous grafts, allogenous grafts, and alloplastic materials. The aim of the present study is to report the advantages of using autogenous calvarial bone grafts over other reconstruction techniques, in the reconstruction of frontal defects. Read More

View Article
September 2018
1 Read

Occurrence of occult CSF leaks during standard FESS procedures.

Rhinology 2018 Jun;56(2):166-171

Department of Immunology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Objective: To determine the incidence of occult cerebrospinal fluid leaks (CSF) after functional endoscopic sinus surgery (FESS) and to evaluate the diagnostic performance of beta2-transferrin in blood-contaminated conditions.

Study Design: Prospective cohort study.

Methods: An analysis of 57 intraoperative samples using hydrogel 6 beta2-transferrin assay after FESS was undertaken. Read More

View Article
June 2018
6 Reads

Parkinson disease in eldery patients: lessons from odour detection thresholds on olfacto-trigeminal interaction.

Rhinology 2018 Jun;56(2):127-132

Department of Otorhinolaryngology, Cliniques universitaires Saint-Luc, Brussels, Belgium.

Background: Human nasal chemosensation is mediated by two separate, though interacting sensory pathways: the trigeminal and olfactory systems. Trigeminal sensitivity and olfacto-trigeminal interactions have not yet been well studied in idiopathic Parkinsons disease (IPD).

Objectives: The aim of this study was to assess odour detection thresholds in elderly IPD patients, and compare them to the odour detection thresholds of healthy controls. Read More

View Article
June 2018
2 Reads

Position paper on olfactory dysfunction.

Rhinol Suppl 2017 03;54(26):1-30

Background: Olfactory dysfunction is an increasingly recognised condition, associated with reduced quality of life and major health outcomes such as neurodegeneration and death. However, translational research in this field is limited by heterogeneity in methodological approach, including definitions of impairment, improvement and appropriate assessment techniques. Accordingly, effective treatments for smell loss are limited. Read More

View Article
March 2017
2 Reads

Eustachian tube symptoms are frequent in chronic rhinosinusitis and respond well to endoscopic sinus surgery.

Rhinology 2018 Jun;56(2):118-121

Department of Otolaryngology-Head and Neck Surgery, The University of Ottawa, Ottawa, ON, Canada.

Background: Symptoms of Eustachian tube (ET) dysfunction are seldom assessed in patients with chronic rhinosinusitis (CRS). The Sino-Nasal Outcome Test (SNOT-22) quality-of-life tool includes two questions that specifically screen for symptoms of ET dysfunction (Ear Fullness; Ear Pain).

Objective: The purpose of this study was to determine the extent to which these ET symptoms were present in patients with CRS, and whether these symptoms respond to endoscopic sinus surgery (ESS). Read More

View Article
June 2018
5 Reads

The accessibility of topical treatment in the paranasal sinuses on operated cystic fibrosis patients assessed by scintigraphy.

Rhinology 2018 Sep;56(3):268-273

Department of Clinical Medicine, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen, Denmark.

Background: Nasal irrigations with antibiotics are used to eradicate Pseudomonas aeruginosa from the upper airways in patients with cystic fibrosis (CF) and thereby avoid lung colonisations; nevertheless, the efficacy is uncertain.

Methodology: The aim of this study was to investigate the accessibility and durability of solutions in the sinuses before and after sinus surgery. The participants irrigated their noses with radioactively marked saline and were evaluated using a dynamic SPECT/CT scan. Read More

View Article
September 2018
2 Reads

Fluorescein transit test time as a tool to assess lacrimal pump function after diode laser transcanalicular dacryocystorhinostomy and external dacryocysto-rhinostomy.

Rhinology 2018 Sep;56(3):274-278

Department of Oculoplastic Surgery of the University of Sao Paulo, Sao Paulo, Brazil.

Background: Dacryocystorhinostomy (DCR) is the gold standard surgical treatment for nasolacrimal duct obstruction. External DCR is the traditional approach (EXT-DCR); however, the advent of minimally invasive surgeries and the development of optic fiber and laser technologies have made it possible to perform laser transcanalicular DCR (T-DCR), a minimally invasive procedure. This study measured the fluorescein transit time (FTT) after EXT-DCR or T-DCR to evaluate the lacrimal drainage and lacrimal pump function after these two types of DCR. Read More

View Article
September 2018
5 Reads

Lower airway flow influences peak nasal inspiratory flow in school-aged children.

Rhinology 2018 Sep;56(3):288-296

Allergy Center, CUF Descobertas Hospital and CUF Infante Santo Hospital, Lisbon, Portugal.

Background: Rhinitis and asthma frequently coexist. Peak nasal inspiratory flow (PNIF) objectively evaluates nasal obstruction. Lower airway flow's impact on PNIF has seldom been analysed in children. Read More

View Article
September 2018
2 Reads

A new year, a new Journal.

Authors:
W J Fokkens

Rhinology 2018 Mar;56(1):1-2

Academic Medical Centre, Amsterdam, The Netherlands.

Let us start this first editorial of 2018 with wishing you all a marvelous year where most of your dreams come true. In the last years, the editors of Rhinology felt often very unhappy when again we had to refuse papers send to us for Rhinology. Unfortunately, every year we can only accept around 15% of the papers we receive. Read More

View Article
March 2018
3 Reads

Upregulation of extraneuronal TRPV1 expression in chronic rhinosinusitis with nasal polyps.

Rhinology 2018 Sep;56(3):245-254

Department of Pharmacology and Pharmacotherapy, University of Pécs Medical School, Pécs, Hungary.

Background: Chronic rhinosinusitis (CRS) is a multifactorial upper airway disease with unclear etiology. Neuronal Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) channels have been implicated in the pathogenesis of CRS. We aimed to detect the expression of extraneuronal TRPV1 and TRPA1 receptors in nasal polyp (NP) tissue samples. Read More

View Article
September 2018
5 Reads