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Indian J Med Microbiol 2021 May 26. Epub 2021 May 26.

Department of Medicine, SP Medical College, Bikaner, Rajasthan, India.

Coronavirus disease 2019 (COVID-19), may present with a myriad of clinical manifestations and complications. Patients with COVID-19 are at increased risk of pulmonary thromboembolism, acute cardiac injury, arrhythmias, acute stroke, and secondary infections. Mucormycosis is a catastrophic fungal infection characterized by vascular invasion, thrombosis, and necrosis of tissues. Read More

J Med Cases 2021 Mar 19;12(3):85-89. Epub 2021 Jan 19.

Christiana Care Health System, 4755 Ogletown Stanton Road, Newark, DE 19718, USA.

As the coronavirus disease 2019 (COVID-19) pandemic is evolving, more complications associated with COVID-19 are emerging. In this case report, we present a case of rhinocerebral mucormycosis concurrent with COVID-19 pneumonia in a 41-year-old man with a history of type 1 diabetes mellitus (T1DM). COVID-19 pneumonia was diagnosed with reverse transcription-polymerase chain reaction (RT-PCR). Read More

Autops Case Rep 2021 Jan 28;11:e2020233. Epub 2021 Jan 28.

Swami Rama Himalayan University, Himalayan Institute of Medical Sciences, Department of Neurosurgery, Dehradun, Uttarakhand, India.

Mucormycosis is an opportunistic fungal disease that commonly presents as cutaneous or rhinocerebral infections associated with immunocompromised states. It may exceptionally present as isolated involvement of the brain with a varied clinical presentation, which may be difficult to diagnose early, leading to increased mortality. Herein, we report the case of a 42-year-old immunocompetent female with left-sided limb weakness and a history of recurrent vomiting and headache for the last two years. Read More

IDCases 2021 12;24:e01120. Epub 2021 Apr 12.

Division of Infectious Diseases, UnityPoint Health, Des Moines, IA, USA.

Background: Mucorales is a zygomycete fungi known to cause opportunistic infections in immunosuppressed hosts. Spores may be inhaled, causing rhinocerebral or pulmonary infections, or gastrointestinal infections if swallowed. Less often, cutaneous mucormycosis develops after inoculation via broken skin. Read More

Diagn Pathol 2021 Apr 21;16(1):34. Epub 2021 Apr 21.

Department of Pathology, The Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China.

Introduction: Rhinocerebral mucormycosis is a rare and severe form of opportunistic fungal infection that can develop rapidly and cause significant mortality, particularly among diabetic patients suffering from ketoacidosis. Diagnosing rhinocerebral mucormycosis during the early stages of infection is challenging.

Case Presentation: We describe a case of rhinocerebral mucormycosis secondary to severe acute pancreatitis in a patient suffering from diabetic ketoacidosis. Read More

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Pathology, KS Hegde Medical Academy, Mangalore, India

Mucormycosis is a rare infection caused by Mucorales fungi belonging to Zygomycetes class. It can present with spectrum of symptoms and signs based of organ involvement. Common forms of mucormycosis includes rhinocerebral, cutaneous, gastrointestinal, pulmonary, disseminated and miscellaneous forms involving bones, breast, kidney and central nervous system. Read More

Intern Med 2021 Mar 8. Epub 2021 Mar 8.

Department of Neurology, Tokyo Women's Medical University, Japan.

We herein report a 73-year-old man who experienced cerebral infarction caused by infection with a Mucromycocetes species. A delay in anti-fungal treatment might result in a lethal clinical outcome. We were unable to establish an accurate diagnosis based on histological findings and cerebrospinal fluid culture. Read More

Arch Plast Surg 2021 Mar 4;48(2):231-236. Epub 2021 Mar 4.

Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, D.C., USA.

Mucormycosis is an invasive, rapidly progressive, life-threatening fungal infection, with a propensity for diabetic, immunosuppressed, and trauma patients. The classic rhinocerebral variation is most common in diabetic patients. While the cutaneous form is usually caused by direct inoculation in immunocompetent patients. Read More

Acta Radiol 2021 Feb 20:284185120988828. Epub 2021 Feb 20.

Neuroradiology UOC, Neuroscience Department, Padova University Hospital, Padova, Italy.

Rhinocerebral mucormycosis (RCM) may result in severe intracranial ischemic and hemorrhagic lesions. Both computed tomography (CT) and magnetic resonance imaging (MRI) play an essential role in the diagnosis of RCM, but whereas CT is better for assessing bone erosion, MRI is superior in evaluating soft tissue, intraorbital extension, and in assessing intracranial and vascular invasion. Specific CT and MRI techniques, such as CT angiography or enhanced MR angiography, and more advanced MRI sequences such as gadolinium-3D Black Blood imaging, contribute to the assessment of the extension of vascular invasion. Read More

Case Rep Infect Dis 2021 27;2021:4381254. Epub 2021 Jan 27.

Kings County Internal Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.

Mucormycosis is a highly invasive and rapidly progressing form of fungal infection that can be fatal. The infection usually begins after oral or nasal inhalation of fungal spores and can enter the host through a disrupted mucosa or an extraction wound. The organism becomes pathogenic when the host is in an immunocompromised state. Read More

An Bras Dermatol 2021 Mar-Apr;96(2):196-199. Epub 2021 Jan 23.

General Hospital Dr. Manuel Gea González Calzada de Tlalpan, Tlalpan, Ciudad de México, México. Electronic address:

The authors present seven cases of rhinocerebral mucormycosis associated to diabetes mellitus, which is a disease with epidemic proportions affecting individuals worldwide, particularly in developing countries, and which poses significant morbidity and mortality. Mucormycosis is an opportunistic fungal infection with high mortality and requires an invasive therapeutic approach to save the patient's life with significant morbidity and sequelae, thus prevention is crucial. Read More

Cureus 2020 Nov 29;12(11):e11776. Epub 2020 Nov 29.

Otolaryngology, University of Basra Hospital, College of Medicine, Basra, IRQ.

Introduction Rhinocerebral mucormycosis (RCM) is a rare, frequently lethal, opportunistic infection of the paranasal sinuses and brain caused by fungi of the Mucoracea family. The overall global incidence is low, with the condition most commonly found in India and the Middle East. Early diagnosis and aggressive treatment are essential. Read More

Indian J Crit Care Med 2020 Nov;24(11):1137-1138

Division of Neuroanesthesia, Department of Anesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Background: Mucormycosis is a rare fungal infection affecting immunocompromised patients, with the rhinocerebral variant as the most common presentation. Garcin syndrome is the progressive involvement of the cranial nerves resulting in total unilateral paralysis of cranial nerves, absence of sensory or motor deficits, and not associated with features of raised intracranial pressure. We report a case of invasive rhinocerebral mucormycosis presenting as Garcin syndrome and acute ischemic stroke. Read More

Acad Forensic Pathol 2020 Jun 25;10(2):72-80. Epub 2020 Nov 25.

Mucormycosis is a rare and severe invasive fungal infection caused by ubiquitous fungi of the order Mucorales. Infection often occurs in immunocompromised hosts and includes cutaneous, pulmonary, gastrointestinal, rhinocerebral, and disseminated forms of disease. Although the clinical characteristics of mucormycosis are well established, infection can be difficult to diagnose antemortem, resulting in frequent postmortem diagnoses. Read More

Br J Neurosurg 2020 Dec 4:1-4. Epub 2020 Dec 4.

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Here we present a case of a poorly controlled diabetic who developed extensive rhinocerebral mucormycosis. Systemic and intrathecal amphotericin were not able to improve his life threatening infection. Therefore, salvage therapy with intracavitary amphotericin B deoxycholate was used to instill antifungal therapy directly into the patient's brain abscess. Read More

Int Med Case Rep J 2020 19;13:531-535. Epub 2020 Oct 19.

Department of Thoracic and Cardiovascular Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Republic of Korea.

Mucormycosis is a rare, life-threatening, and opportunistic fungal infection that usually occurs in immunocompromised patients. Rhinocerebral and pulmonary manifestations are the common form. The rare form of gastrointestinal mucormycosis occur in all parts of the alimentary tract, with emphasis on the stomach being the most common site. Read More

Indian J Dent Res 2020 Jul-Aug;31(4):652-655

Department of Orthodontia, AME'S, Dental College and Hospital, Raichur, Karnataka, India.

Mucormycosis, caused by saprophytic fungi of the order Mucorales of the class zygomycetes, is a rare opportunistic fungal infection, which has a rapidly progressive and fulminant course with fatal outcome. Mucormycosis can result in an acute, rapidly advancing and occasionally fatal disease caused by different fungi typically found in the soil in association with decaying organic matter such as leaves, compost piles, or bread molds. Mucormycosis is not contagious and does not spread from person to person. Read More

Med Mycol Case Rep 2020 Dec 25;30:22-25. Epub 2020 Sep 25.

Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

A 70-year-old Japanese man undergoing remission induction therapy for acute monocytic leukemia (AML-M5b) developed fever and headache, and was started on antibiotics and liposomal amphotericin B (L-AMB). There was no improvement, and computed tomography and contrast-enhanced magnetic resonance imaging revealed acute rhinosinusitis and brain abscess. Successful endoscopic endonasal surgery was performed at this point, providing drainage for the rhinosinusitis and abscess. Read More

Access Microbiol 2020 17;2(8):acmi000139. Epub 2020 Jun 17.

Department of Microbiology, PGIMER and Dr Ram Manohar Lohia Hospital, New Delhi, India.

Zygomycosis and aspergillosis are two serious fungal infections that are commonly seen in immunocompromised patients. Since both of these infections involve fungi that invade vessels of the arterial system, an early and rapid diagnosis by direct examination of KOH mounts of the relevant clinical sample can clinch the diagnosis. Here, we present a case of a 60-year-old diabetic patient who presented with swelling and pain over the nose and left eye for 7 days with loss of vision in the left eye. Read More

Cureus 2020 Aug 7;12(8):e9610. Epub 2020 Aug 7.

Radiology, University of Arizona College of Medicine - Tucson, Tucson, USA.

Mucormycosis is an aggressive fungal disease that can occur in individuals with certain predisposing factors, such as diabetes mellitus and pharmacologic immunosuppression. An astounding aspect of this disease is the speed at which it can spread to surrounding structures once it begins to germinate inside the human body. This case involves a 24-year-old male patient who presented to the emergency room complaining of a headache after a dental procedure who developed fulminant rhinocerebral mucormycosis within days. Read More

Infection 2021 Feb 27;49(1):165-170. Epub 2020 Jul 27.

Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, Japan.

A 42-year-old man diagnosed with acute myeloid leukemia complained of progressive swelling of the right side of his face with pain 11 days after the third cycle of consolidation therapy with high-dose arabinosylcytosine-cytarabine. Head and neck magnetic resonance imaging showed a mass lesion in his right maxillary sinus with parapharyngeal involvement, which included the right masseter muscle, intraorbital involvement, and an abscess in his brain. Chest computed tomography revealed peribronchial small nodules in his right upper lobe and a necrotic tumor in his right lower lobe. Read More

Otolaryngol Pol 2020 Feb;74(4):37-40

Mahatma Gandhi Medical College and Research Institutesri Balaji Vidyapeeth.

<b>Background:</b> Mucormycosis is a rare fungal infection affecting people with impaired immunity. The aim of this study is to shed light on the epidemiology, incidence, and outcome of patients with mucormycosis hospitalized at a tertiary care center in Pondicherry. <br><b>Methods:</b> We conducted a retrospective chart review between January 2008 and January 2018. Read More

Curr Med Mycol 2020 ;6(1):30-35

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background And Purpose: Organ transplant recipients are vulnerable to fungal infections. The aim of this study was to determine the prevalence of fungal colonization and infections among patients who underwent various transplantations and molecularly characterize the etiological agents.

Materials And Methods: This study was conducted on candidates for transplantation in Imam Khomeini Hospital, Tehran, Iran, from April 2017 to April 2018. Read More

Mycopathologia 2020 Jun 9;185(3):555-567. Epub 2020 May 9.

Department of Dermatology, The Affiliated Hospital, Guizhou Medical University, Beijing Road 4, Yunyan District, Guiyang, China.

Background: Lichtheimia species are emerging opportunistic fungal pathogens in the Mucorales, causing serious skin and respiratory infections in immunocompromised patients. Established agents are Lichtheimia corymbifera and L. ramosa, while L. Read More

J Hand Surg Am 2020 Dec 23;45(12):1189.e1-1189.e5. Epub 2020 Mar 23.

Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY.

Mucormycosis is a relatively rare but extremely aggressive fungal infection that commonly affects patients who are compromised hosts. These infections typically come in various patterns: pulmonary, sinus, rhinocerebral, cerebral, cutaneous, or disseminated forms. Treatment usually consists of a combination of antifungal agents and surgical debridement, although morbidity and mortality are high. Read More

J Radiol Case Rep 2019 Oct 31;13(10):1-10. Epub 2019 Oct 31.

Department of Radiodiagnosis, B J Govt. Medical College & Sassoon General Hospitals, Pune, India.

Mucormycosis is a rare opportunistic fungal infection, often life-threatening. We report an unusual case of rhinocerebral mucormycosis in an immunocompetent patient. A 23-year-old male presented with headache, speech disturbance and hearing difficulty for 4 weeks. Read More

Br J Haematol 2020 04 29;189(2):339-350. Epub 2019 Dec 29.

The Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petah Tikva, Israel.

Mucormycosis has emerged as an increasingly important cause of morbidity and mortality in immunocompromised patients, but contemporary data in children are lacking. We conducted a nationwide multicentre study to investigate the characteristics of mucormycosis in children with haematological malignancies. The cohort included 39 children with mucormycosis: 25 of 1136 children (incidence 2·2%) with acute leukaemias prospectively enrolled in a centralized clinical registry in 2004-2017, and an additional 14 children with haematological malignancies identified by retrospective search of the databases of seven paediatric haematology centres. Read More

Clin Transplant 2020 02 9;34(2):e13774. Epub 2020 Jan 9.

Pulmonary Institute, Rabin Medical Center, Petach Tiqwa, Israel.

Background: Mucormycosis is a rare infection in lung transplant recipients (LTR). Our objective was to better define the clinical presentation and optimal management of this frequently lethal infection.

Methods: A systematic review of the literature was performed to identify all published cases of mucormycosis in LTR using PubMed/MEDLINE. Read More