33,921 results match your criteria Rhinitis Allergic


Risk Factors for Post-infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis.

Front Pediatr 2022 9;10:881908. Epub 2022 Jun 9.

Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China.

Background: Post-infectious bronchiolitis obliterans (PIBO) is a long-term sequela after an initial insult to the lower respiratory tract. A comprehensive understanding of the factors that contribute to a high risk of developing PIBO is important to help define therapeutic strategies and improve prognosis.

Methods: We performed a systematic review of published literature available in the online databases including PubMed, Embase, Web of Science, CNKI, Wan Fang, and VIP, with the last search updated on 27 January 2022. Read More

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The Role of Small Extracellular Vesicles and MicroRNAs in the Diagnosis and Treatment of Allergic Rhinitis and Nasal Polyps.

Mediators Inflamm 2022 16;2022:4428617. Epub 2022 Jun 16.

Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Allergic rhinitis and nasal polyps are common otorhinolaryngological diseases. Small extracellular vesicles and microRNAs have recently become major research topics of interest due to their key regulatory roles in cancer, inflammation, and various diseases. Although very detailed and in-depth studies on the pathogenesis and pathophysiology of allergic rhinitis and nasal polyps have been conducted, few studies have assessed the regulatory effects of exosomes and microRNAs on allergic rhinitis and nasal polyps. Read More

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lncRNA FR215775 Regulates Th2 Differentiation in Murine Allergic Rhinitis.

J Immunol Res 2022 14;2022:7783481. Epub 2022 Jun 14.

Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai 200031, China.

To identify the effect of long noncoding RNA (lncRNA) FR215775 in regulating CD4+ T cells on murine models of allergic rhinitis (AR), the expression of lncRNA FR215775 in primary Th2 cells was detected through qRT-PCR. After knocking down the expression of lncRNA FR215775 via Sh-FR215775-Ads, Cell Counting Kit-8, cytometric bead array, and fluorescence-activated cell sorting were performed to determine its functions in vitro. Moreover, lncRNA FR215775-silencing or nonsilencing cells were injected intravenously into AR mice. Read More

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Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder.

Pediatr Allergy Immunol 2022 Jun;33(6)

Clinical Immunology Allergy and AIDS Center, Kaplan Medical Center, Rehovot, Israel.

Background: Previous studies reported controversial results regarding the association between allergic disorders and attention deficit hyperactivity disorder (ADHD)/autism spectrum disorder (ASD). The aim of this article was to investigate whether allergic disorders are associated with ADHD/ASD in a large cohort of pediatric patients.

Methods: A retrospective study using the pediatric (0-18 year) database (ICD-9-CM codes) of Clalit Health Services during the years (2000-2018). Read More

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Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci.

Eur Heart J 2022 Jun 25. Epub 2022 Jun 25.

Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Building 9312, Henrik Harpestrengs Vej 4C, 2100 Copenhagen, Denmark.

Aims: To search for sequence variants associated with ACEi discontinuation and to test their association with ACEi-associated adverse drug reactions (ADRs).

Methods And Results: A genome-wide association study (GWAS) on ACEi discontinuation was conducted, including 33 959 ACEi-discontinuers and 44 041 controls. Cases were defined as persons who switched from an ACEi treatment to an angiotensin receptor blocker. Read More

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Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation.

Chin J Nat Med 2022 Jun;20(6):443-457

Institute of Otolaryngology, Institute of Hearing and Speech of Sun Yat-sen University, Sun Yat-sen Me-morial Hospital, Sun Yat-sen University, Guangzhou 510520, China. Electronic address:

Antibiotic exposure-induced dysbiosis of the intestinal flora increases the risk of developing allergic rhinitis. Hence, regulating the balance of intestinal flora may be useful for preventing and treating allergic rhinitis. However, the underlying mechanism is unclear. Read More

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The Environmental Microbiome, Allergic Disease and Asthma.

J Allergy Clin Immunol Pract 2022 Jun 21. Epub 2022 Jun 21.

Department of Internal Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address:

The environmental microbiome represents the entirety of the microbes and their metabolites that we encounter in our environments. A growing body of evidence supports the role of the environmental microbiome in risk for and severity of allergic diseases and asthma. The environmental microbiome represents a ubiquitous, lifelong exposure to non-self antigens. Read More

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Smart Peptide Defense Web In Situ Connects for Continuous Interception of IgE against Allergic Rhinitis.

ACS Appl Mater Interfaces 2022 Jun 24. Epub 2022 Jun 24.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Haidian District, Beijing 100190, P. R. China.

Allergic rhinitis (AR) is a chronic inflammatory reaction by immunoglobulin E (IgE) mediators after individual contact with allergens. It affects 10-40% of the world's population and reduces the quality of life. Long-term symptoms of rhinitis can cause inflammation to spread and trigger asthma, which can harm human health. Read More

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Efficacy and Safety of Rupatadine Fumarate Combined with Acupoint Application in Allergic Rhinitis Complicated with Diabetes.

Comput Intell Neurosci 2022 14;2022:6935758. Epub 2022 Jun 14.

Department of Otolaryngology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

The prevalence of allergic rhinitis has exhibited an upward trend, and diabetes is a common endocrine metabolic disorder. Treatment of allergic rhinitis complicated with diabetes has been marginally explored. This study aimed to observe the effect of rupatadine fumarate combined with acupoint application in the treatment of allergic rhinitis complicated with diabetes and its effect on serum IgE levels. Read More

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Ameliorative Effect of a Neoteric Regimen of Catechin plus Cetirizine on Ovalbumin-Induced Allergic Rhinitis in Rats.

Life (Basel) 2022 May 31;12(6). Epub 2022 May 31.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Minia University, El-Minia 61511, Egypt.

Allergic rhinitis (AR) affects 20-50% of the global population. Available treatments are limited by their adverse effects. We investigated the anti-allergic effects of catechin alone and combined with cetirizine against ovalbumin-induced AR. Read More

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The Role of Allergen-Specific Immunotherapy in ENT Diseases: A Systematic Review.

J Pers Med 2022 Jun 9;12(6). Epub 2022 Jun 9.

Unit of Otorhinolaryngology Head and Neck Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Previous studies have demonstrated that both subcutaneous (SCIT) and sublingual specific immunotherapy (SLIT) are effective in treating allergic rhinitis (AR). Further studies have evaluated the efficacy of allergen-specific immunotherapy (AIT) on different ear, nose, and throat (ENT) manifestations, in which allergy might have an etiopathogenetic role, such as local allergic rhinitis (LAR), rhinosinusitis (RS), otitis media (OM), and adenotonsillar (AT) disease. Nevertheless, the management of allergy in ENT diseases is still debated. Read More

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From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine.

J Pers Med 2022 May 28;12(6). Epub 2022 May 28.

La Roche-Posay International, 92300 Levallois-Perret, France.

Atopic dermatitis (AD) affects up to 20% of children and is considered the starting point of the atopic march with the development of food allergy, asthma, and allergic rhinitis. The heterogeneous phenotype reflects distinct and/or overlapping pathogenetic mechanisms with varying degrees of epidermal barrier disruption, activation of different T cell subsets and dysbiosis of the skin microbiome. Here, we review current evidence suggesting a systemic impact of the cutaneous inflammation in AD together with a higher risk of asthma and other comorbidities, especially in severe and persistent AD. Read More

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A Review of the Respiratory Health Burden Attributable to Short-Term Exposure to Pollen.

Int J Environ Res Public Health 2022 Jun 20;19(12). Epub 2022 Jun 20.

Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3053, Australia.

Respiratory diseases such as asthma, allergic rhinitis (AR) and chronic obstructive pulmonary disease (COPD) affect millions worldwide and pose a significant global public health burden. Over the years, changes in land use and climate have increased pollen quantity, allergenicity and duration of the pollen season, thus increasing its impact on respiratory disease. Many studies have investigated the associations between short-term ambient pollen (i. Read More

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Screening Accuracy of FeNO Measurement for Childhood Asthma in a Community Setting.

Children (Basel) 2022 Jun 8;9(6). Epub 2022 Jun 8.

Department of Epidemiology, Poland Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.

(1) Background: The exhaled fractional nitric oxide is a well-recognized biomarker used in clinical settings for controlling and managing asthma. Less is known about the value of Fractional Exhaled Nitric Oxide (FeNO) measurement in epidemiological studies on childhood asthma, although available evidence suggests that an increased FeNO is associated with an increased risk of asthma. (2) Aim: The aim of the study was to assess FeNO accuracy in the identification of children with asthma, participants in a population-based respiratory survey. Read More

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Circulating MMP-12 as Potential Biomarker in Evaluating Disease Severity and Efficacy of Sublingual Immunotherapy in Allergic Rhinitis.

Mediators Inflamm 2022 12;2022:3378035. Epub 2022 Jun 12.

Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School of University of South China, Changsha, Hunan 410000, China.

Background: Allergic rhinitis (AR) is a highly heterogeneous disease, and allergen-specific immunotherapy (AIT) is an effective treatment. This study aims to evaluate the circulating mas-related G protein-coupled receptor-X2 (MRGPRX2) and matrix metalloproteinase-12 (MMP-12) levels in evaluating disease severity and predicting efficacy of SLIT in AR patients.

Methods: We enrolled 110 moderate-severe persist AR patients (AR group) and 40 healthy controls (HC group). Read More

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Chemokines and chemokine receptors in allergic rhinitis: from mediators to potential therapeutic targets.

Eur Arch Otorhinolaryngol 2022 Jun 23. Epub 2022 Jun 23.

Department of Laboratory Medicine, China Medical University, Shenyang, China.

Allergic rhinitis (AR) is an immune-mediated inflammatory condition characterized by immune cell infiltration of the nasal mucosa, with symptoms of rhinorrhea, sneezing, nasal obstruction, and itchiness. Currently, common medication for AR is anti-inflammatory treatment including intranasal steroids, oral, or intranasal anti-histamines, and immunotherapy. These strategies are effective to the majority of patients with AR, but some patients under medication cannot achieve symptom relieve and suffer from bothersome side effects, indicating a demand for novel anti-inflammatory treatment as alternatives. Read More

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[Allergenic risk analysis of street trees of urban alleys in Qingyang District, Chengdu, China].

Ying Yong Sheng Tai Xue Bao 2022 Jun;33(6):1615-1621

Department of Landscape, Southwest Jiaotong University, Chengdu 610031, China.

We examined the pollen allergy risk of street trees in urban alleys, with 410 urban alleys in Qingyang District, Chengdu as an example. On the basis of recording the characteristics of street trees, we calculated the index of allergenicity of urban green zones () values and overlay the regional population density map, and finally obtained the pollen allergy risk map of urban alleys in Qingyang District. The results showed that there were 32461 street trees in 410 urban alleys, belonging to 27 families, 41 genera, and 52 species. Read More

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Fifteen-minute consultation: Child with persistent runny nose.

Arch Dis Child Educ Pract Ed 2022 Jun 21. Epub 2022 Jun 21.

Department of Paediatric Allergy, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

A child with persistent runny nose may cause significant parental anxiety and healthcare utilisation. While the most common diagnoses are recurrent acute viral upper respiratory tract infections and allergic rhinitis, a careful history and examination is necessary to exclude other causes and to identify comorbidities. Treatment can then be tailored to the underlying cause. Read More

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Comparing available treatments for pollen-induced allergic rhinitis in children.

Expert Rev Clin Immunol 2022 Jun 23:1-9. Epub 2022 Jun 23.

Department of Outpatients, Casa Di Cura Villa Serena, Genoa, Italy.

Introduction: Pollen-induced allergic rhinitis (PIAR) is a widespread disease in children, and its prevalence is rapidly evolving. In addition, it may be associated with other atopic diseases, in particular asthma. In most cases, PIAR can be treated effectively by avoiding exposure to responsible allergens and using symptomatic treatments, including intranasal/oral antihistamines or/and nasal corticosteroids, according to ARIA guidelines. Read More

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Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model.

Int J Immunopathol Pharmacol 2022 Jan-Dec;36:3946320221109529

Department of Otorhinolaryngology, 74566The First Affiliated Hospital of Soochow University, Suzhou, China.

Eosinophilic chronic rhinosinusitis (ECRS) is a chronic inflammatory disease characterized by prominent eosinophilic infiltration along with a T-helper-2 (Th2) response. It has been well documented that signal transducer and activator of transcription 6 (STAT6) is a nuclear transcription factor that mediates Th2-type immunity and is implicatory of STAT1 and STAT3 in the pathogenesis of allergic airway diseases. However, little is known about the association between STATs and ECRS. Read More

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Ocular allergy in children and adolescents.

Allergol Immunopathol (Madr) 2022 20;50(S Pt 1):30-36. Epub 2022 May 20.

Federal University of Parana, Curitiba, Brazil.

The association between symptoms of asthma, rhinoconjunctivitis (RC) and allergic conjunctivitis (AC) is frequent, and AC is considered a comorbidity of asthma and allergic rhinitis (AR). Ocular symptoms are often underestimated and undertreated.Differences according to gender were reported, because girls present symptoms more frequently. Read More

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Intranasal budesonide for rhinitis during a high airborne pollution period: a randomized controlled trial.

Allergy Asthma Clin Immunol 2022 Jun 20;18(1):56. Epub 2022 Jun 20.

Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Background: Air pollution may induce or reinforce nasal inflammation regardless of allergy status. There is limited direct clinical evidence informing the treatment of airborne pollution-related rhinitis.

Objective: To assess the effectiveness of intranasal budesonide in adults with self-reported rhinitis symptoms triggered/worsened by airborne pollution. Read More

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[Research progress of extracellular vesicles in chronic rhinosinusitis and allergic rhinitis].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):778-782

Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Institute of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong 226001, China.

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[Analysis of relationship between distribution of pathogenic microorganisms in olfactory cleft and olfactory disorders among patients with upper respiratory inflammation during the prevention and control of COVID-19].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Jun;57(6):683-691

Department of Otorhinolaryngology Head and Neck Surgery, Capital Institute of Pediatrics, Beijing 100020, China.

To explore the relationship between pathogens in the olfactory cleft area and olfactory disorders in patients with upper respiratory inflammation (URI) during the prevention and control of 2019 novel coronavirus disease (COVID-19). A total of 234 URI patients including acute upper respiratory infection, chronic rhinosinusitis (CRS), allergic rhinitis (AR) were continuously selected from September 2020 to March 2021 in Beijing Anzhen Hospital and 98 healthy adults were enrolled as controls. The secretions from the olfactory cleft of all subjects were collected with nasal swabs under nasal endoscopy. Read More

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Optimal Device and Regimen of Nasal Saline Treatment for Sinonasal Diseases: Systematic Review.

OTO Open 2022 Apr-Jun;6(2):2473974X221105277. Epub 2022 Jun 13.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Objective: This review aimed to systematically determine the optimal nasal saline regimen for different types of sinonasal diseases.

Data Sources: PubMed, Embase, SCOPUS, Cochrane Library, Web of Science, ClinicalTrials.gov. Read More

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Current Strategies to Modulate Regulatory T Cell Activity in Allergic Inflammation.

Front Immunol 2022 26;13:912529. Epub 2022 May 26.

Department of Dermatology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.

Over the past decades, atopic diseases, including allergic rhinitis, asthma, atopic dermatitis, and food allergy, increased strongly worldwide, reaching up to 50% in industrialized countries. These diseases are characterized by a dominating type 2 immune response and reduced numbers of allergen-specific regulatory T (Treg) cells. Conventional allergen-specific immunotherapy is able to tip the balance towards immunoregulation. Read More

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Efficacy of a house dust mite sublingual immunotherapy tablet as add-on dupilumab in asthma with rhinitis.

Allergol Int 2022 Jun 16. Epub 2022 Jun 16.

Department of Radiology, Atami Hospital, International University of Health and Welfare, Atami, Japan.

Background: HDM SLIT is one of the disease-modifying treatment for allergic asthma, and has demonstrated efficacy in clinical trials. Dupilumab, blocks IL-4 and IL-13 signaling, key drivers of type 2 inflammation, and is approved for patients with uncontrolled, moderate-to-severe asthma. The aim of this study was to evaluate outcomes after HDM SLIT initiation in asthma with rhinitis not optimally controlled with dupilumab in a real-world setting. Read More

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[Multiplex PCR method for simultaneous identification of Xanthii Fructus and its adulterants].

Zhongguo Zhong Yao Za Zhi 2022 May;47(10):2605-2613

Anhui University of Chinese Medicine Hefei 230012, China Institute of Traditional Chinese Medicine Resources Protection and Development, Anhui Academy of Chinese Medicine Hefei 230012, China Anhui Province Key Laboratory of Research & Development of Chinese Medicine Hefei 230012, China.

The purpose of this study is to establish a molecular method to identify Xanthii Fructus and two adulterants, the fruits of Xanthium mongolicum and X. italicum. Xanthii Fructus is the fruit of X. Read More

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Automated classification of nasal polyps in endoscopy video-frames using handcrafted and CNN features.

Comput Biol Med 2022 Jun 13;147:105725. Epub 2022 Jun 13.

Department of Computer Engineering, Firat University Faculty of Engineering, Elazig, Turkey. Electronic address:

Nasal polyps are edematous polypoid masses covered by smooth, gray, shiny, soft and gelatinous mucosa. They often pose a threat for the patients to result in allergic rhinitis, sinus infections and asthma. The aim of this paper is to design a reliable rhinology assistance system for recognizing the nasal polyps in endoscopic videos. Read More

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Intranasal antihistamine and corticosteroid to treat in allergic rhinitis: A systematic review and meta-analysis.

Allergy 2022 Jun 18. Epub 2022 Jun 18.

Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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