29,420 results match your criteria Rhinitis Allergic


Changes among TGF-β1 Breg cells and helper T cell subsets in a murine model of allergic rhinitis with prolonged OVA challenge.

Int Immunopharmacol 2019 Feb 15;69:347-357. Epub 2019 Feb 15.

Department of Otolaryngology of Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning, China. Electronic address:

Background: Allergic rhinitis is a common allergic disease resulting from inappropriate Th2 cell-mediated immune responses to environmental antigens. As such, regulatory B cells and T helper cells play a critical role in the occurrence and development of allergic rhinitis.

Methods: Wild-type mice received ovalbumin (OVA) intranasal challenge for varied lengths of time, then the inflammatory state of their nasal mucosa was analyzed by histology. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.009DOI Listing
February 2019

Nasal IgE Production in Allergic Rhinitis: Impact of Rhinovirus Infection.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

Departments of Medicine, University of Virginia Health System, Charlottesville, VA, 22908.

Background: Rhinovirus (RV) infections exacerbate asthma in part by enhancing an allergic state and these exacerbations can be mitigated via administration of anti-IgE.

Objective: We investigated the presence of local IgE production in the nose of allergic and non-allergic subjects and assessed whether this was enhanced by RV.

Methods: Local production of specific IgE was determined by comparing ratios of specific to total IgE concentrations between nasal and serum samples. Read More

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http://dx.doi.org/10.1111/cea.13372DOI Listing
February 2019

Identification of microbial contaminants in sinus rinse squeeze bottles used by allergic rhinitis patients.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 5;5(1):26-29. Epub 2019 Jan 5.

Medical University of South Carolina, Department of Otolaryngology, Head & Neck Surgery, Charleston, SC, USA.

Objective: To identify whether irrigation devices become contaminated when used by patients with allergic rhinitis (AR).

Methods: Ten AR patients with no clinical or endoscopic evidence of active sinonasal infection were given a sinus rinse system and instructed on its proper use, cleaning, and storage. Two squeeze bottles (bottle A and bottle B) were given to each patient for twice-a-day rinsing. Read More

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http://dx.doi.org/10.1016/j.wjorl.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364664PMC

Real-world characteristics and disease burden of patients with asthma prior to treatment initiation with mepolizumab or omalizumab: a retrospective cohort database study.

J Asthma Allergy 2019 25;12:43-58. Epub 2019 Jan 25.

Respiratory, US Medical Affairs, GSK, La Jolla, CA, USA.

Purpose: Patients with severe asthma are eligible for asthma-specific biologics as add-on therapies, such as mepolizumab and omalizumab, when optimized controller therapies are unable to control their symptoms. However, few real-world data are available to describe the characteristics and associated economic burden of patients considered to be candidates for mepolizumab or omalizumab therapy.

Methods: This retrospective cohort study investigated patients with asthma (≥12 years of age) identified at the time of first mepolizumab or omalizumab administration (index date) in the MarketScan Commercial Database. Read More

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http://dx.doi.org/10.2147/JAA.S189676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354698PMC
January 2019

The impact of allergic rhinitis on gastrointestinal disorders among young adults.

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated. Read More

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http://dx.doi.org/10.1111/jep.13108DOI Listing
February 2019

[Clinicopathological characteristics and diagnosis of IgG4related sialadenitis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):1-3

Department of Oral Radiology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated disease and one of immunoglobulin G4-related diseases (IgG4-RD). Our multidisciplinary research group investigated the clinicopathological characteristics and diagnosis of IgG4-RS during the past 10 years. Clinically, it showed multiple bilateral enlargement of major salivary glands (including sublingual and accessory parotid glands) and lacrimal glands. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.001DOI Listing
February 2019

Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population.

Int J Pediatr Otorhinolaryngol 2019 Feb 5;120:58-63. Epub 2019 Feb 5.

Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address:

Objectives: Asthma and allergic rhinitis (AR) frequently occur as comorbid diseases of the upper airways. Single-nucleotide polymorphisms (SNPs) in the FCRL3 and FCRL5 genes have recently been shown to be associated with various immune-related disorders. This study evaluated the association of FCRL3 and FCRL5 polymorphisms with asthma and allergic rhinitis (AR) in a Han Chinese population. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.015DOI Listing
February 2019

Cough in exercise and athletes.

Pulm Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Canada.

In the general population, particularly in individuals with asthma, cough is a common symptom, often reported after exertion, although regular exercise may be associated with a reduction in the prevalence of cough. In athletes, exercise-induced cough is also a particularly frequent symptom. The main etiologies of cough in athletes are somewhat similar to non-athletes, including asthma/airway hyperresponsiveness, upper airways disorders such as allergic or non-allergic rhinitis, and exercise-induced laryngeal obstruction, although these conditions are more frequently observed in athletes. Read More

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http://dx.doi.org/10.1016/j.pupt.2019.02.003DOI Listing
February 2019

Cromolyn-crosslinked chitosan nanoparticles for the treatment of allergic rhinitis.

Eur J Pharm Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacy and Biotechnology, Via San Donato 19/2, University of Bologna, 40127 Bologna, Italy. Electronic address:

The aim of this work was to prepare new mucoadhesive nasal decongestant nanoparticles obtained by direct crosslinking between the cationic polymer chitosan and the anionic drug cromolyn. Different chitosan/cromolyn molar ratios were used in order to obtain nanoparticles of suitable size, encapsulation efficiency/drug loading and mucoadhesion. Moreover, the ability of the nanoparticles to deliver cromolyn into and through the nasal mucosa was evaluated. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.02.015DOI Listing
February 2019

Birch pollen allergen immunotherapy reprograms nasal epithelial transcriptome and recovers microbial diversity.

J Allergy Clin Immunol 2019 Feb 12. Epub 2019 Feb 12.

Haartman Institute, University of Helsinki, Helsinki, Finland; Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

Nasal epithelial transcriptome is altered by the season. Birch pollen allergen immunotherapy recovers microbial community diversity and alters expression of allergy related genes. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.002DOI Listing
February 2019

The Role of Probiotics in Preventing Allergic Disease.

Children (Basel) 2019 Feb 5;6(2). Epub 2019 Feb 5.

Department of Pediatrics, Section of Immunology, Allergy, Rheumatology, and Retrovirology, Texas Children's Hospital, Houston, TX 77030, USA.

The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. Read More

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http://dx.doi.org/10.3390/children6020024DOI Listing
February 2019

Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions.

Med Sci (Basel) 2019 Feb 5;7(2). Epub 2019 Feb 5.

Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory upper airway disease, accompanied mainly by eosinophilia and/or asthma. In addition, the disease correlates with a high rate of hyposmia, following a marked infiltration of eosinophils into the inflamed site, the paranasal sinus. Although eosinophils are known to contribute to the development of hyposmia and CRSwNP pathology, the underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.3390/medsci7020022DOI Listing
February 2019

Broad Immunglobulin G Repertoire in Chronic Rhinosinusitis with Nasal Polyps regulates pro-inflammatory IgE responses.

J Allergy Clin Immunol 2019 Feb 11. Epub 2019 Feb 11.

Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE-idiotypes. Whilst tissue IgE concentrations can be in the range of several thousand kU/L, the regulatory mechanisms by which IgE-mediated inflammation is controlled in the nasal polyps is not well understood.

Objective: We sought to determine whether locally induced IgG antibodies in the nasal polyps can inhibit IgE-mediated pro-allergic response. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.001DOI Listing
February 2019

DNA methylation and allergic sensitizations, a genome-scale longitudinal study during adolescence.

Allergy 2019 Feb 14. Epub 2019 Feb 14.

Sachs' Children's Hospital, Stockholm, Sweden.

Background: The presence of allergic sensitization has a major influence on the development and course of common childhood conditions such as asthma and rhinitis. The etiology of allergic sensitization is poorly understood and its underlying biological mechanisms are not well established. Several studies showed that DNA methylation (DNAm) at some CpGs is associated with allergic sensitization. Read More

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http://dx.doi.org/10.1111/all.13746DOI Listing
February 2019

Asthma and atopy prevalence are not reduced among former tuberculosis patients compared with controls in Lima, Peru.

BMC Pulm Med 2019 Feb 13;19(1):40. Epub 2019 Feb 13.

The University of Sydney, St. Vincent's Hospital Sydney, Heart Lung Clinic, Xavier Building. 390, Victoria Street, 2010, Australia.

Background: Although there are theoretical reasons for believing that asthma and atopy may be negatively correlated with tuberculosis, epidemiological studies have had conflicting findings.

Objective: To determine if people with confirmed tuberculosis were less likely to be atopic and less likely to have atopic disease including asthma compared to those with no previous tuberculosis.

Methods: Patients in Lima, Peru with a prior history of tuberculosis were identified from clinic records in this cohort study. Read More

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http://dx.doi.org/10.1186/s12890-019-0804-zDOI Listing
February 2019

Development of a gold nanoparticle-labeled sandwich format lateral flow immunoassay kit for the detection of tropical house dust mite Suidasia pontifica.

Protein Pept Lett 2019 Feb 12. Epub 2019 Feb 12.

The Graduate School, bCollege of Science, University of Santo Tomas, España Boulevard, Sampaloc 1015, Manila. Philippines.

The house dust mite Suidasia pontifica (Sp) is an important source of allergens in tropical regions that trigger IgE-mediated allergic reactions such as allergic asthma, atopic dermatitis and allergic rhinitis. Detection of Sp-specific proteins are important in the management and prevention of allergic diseases. The study aimed to provide a proof of concept for a gold nanoparticle-labeled sandwich format lateral flow immunoassay (LFIA) kit for the detection of Sp-specific proteins. Read More

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http://dx.doi.org/10.2174/0929866526666190212164751DOI Listing
February 2019
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1.068 Impact Factor

Effect of intra-urban temperature variation on tree flowering phenology, airborne pollen, and measurement error in epidemiological studies of allergenic pollen.

Sci Total Environ 2019 Feb 5;653:1213-1222. Epub 2018 Nov 5.

School of Public Health, University of Michigan- Ann Arbor, Ann Arbor, MI, USA.

Temperature gradients in cities can cause inter-neighborhood differences in the timing of pollen release. However, most epidemiological studies examining allergenic pollen utilize daily measurements from a single pollen monitoring station with the implicit assumption that the measured time series of airborne pollen concentrations applies across the study areas, and that the temporal mismatch between concentrations at the counting station and elsewhere in the study area is negligible. This assumption is tested by quantifying temperature using satellite imagery, observing flowering times of oak (Quercus) and mulberry (Morus) trees at multiple sites, and collecting airborne pollen. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.020DOI Listing
February 2019

Occupational asthma and rhinitis: Do we think about it as soon as possible?

Cas Lek Cesk 2019 ;157(8):406-410

Occupational asthma and allergic diseases of the upper airway play an important role in occupational diseases. The most frequent allergens, which causes occupational respiratory diseases in the Czech Republic, are isocyanates and wheat and rye flour. Isocyanates are the substances used in car industry during production of polyurethanes, they are in colours and glues. Read More

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January 2019

Diagnostics and acknowledgement of occupational diseases - topics and challenges in the Czech Republic.

Cas Lek Cesk 2019 ;157(8):396-399

The causes of occupational diseases are changing, thats why a regular update of Czech List of Occupational Diseases is needed. New compensable occupational diseases, such as cancer of the larynx and ovarian cancer due to asbestos, and chronic obstructive pulmonary diseases due to black coal dust were included in the last two updates of the Czech List. The need of an early examination at the Centers of Occupational Diseases is stressed in this article, especially before a surgery or other treatment of epicondylitis and carpal tunnel syndrome. Read More

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January 2019

Regulation of Interaction between the Upper and Lower Airways in United Airway Disease.

Med Sci (Basel) 2019 Feb 11;7(2). Epub 2019 Feb 11.

Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata, 573-1010, Japan.

The concept of united airway disease comprises allergic rhinitis (AR) with asthma, and eosinophilic chronic rhinosinusitis (ECRS) with asthma. It embodies a comprehensive approach to the treatment of upper and lower airway inflammation. The treatment of upper airway inflammation reduces asthma symptoms and decreases the dose of inhaled corticosteroids (ICS) necessary to treat asthma. Read More

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http://dx.doi.org/10.3390/medsci7020027DOI Listing
February 2019

Acute rhinosinusitis among pediatric patients with allergic rhinitis: A nationwide, population-based cohort study.

PLoS One 2019 12;14(2):e0211547. Epub 2019 Feb 12.

Graduate Institute of Long-Term Care, Tzu Chi University of Science and Technology, Hualien City, Hualien, Taiwan.

Background: While chronic rhinosinusitis is a common complication of allergic rhinitis, the link between acute rhinosinusitis and allergic rhinitis is unclear. The aim of this study was to evaluate the risk of incident acute rhinosinusitis among pediatric patients with allergic rhinitis, using a nationwide, population-based health claims research database.

Methods: Newly diagnosed allergic rhinitis patients aged 5-18 years were identified from the health claim records of the Longitudinal Health Insurance Database 2000 of Taiwan's National Health Insurance Research Database. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211547PLOS
February 2019

Prevalence of asthma, allergic rhinitis and eczema in 6-7-year-old schoolchildren from Luanda, Angola.

Allergol Immunopathol (Madr) 2019 Feb 8. Epub 2019 Feb 8.

Department of Allergy & Clinical Immunology, Cova da Beira University Hospital, Quinta do Alvito, 6200-251 Covilhã, Portugal; CICS - Health Sciences Research Centre, University of Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal. Electronic address:

Background: Epidemiological data have shown that the prevalence of asthma, rhinoconjunctivitis and eczema in children is still increasing, namely in Africa. However, there are no epidemiological studies on asthma or allergic diseases in Angolan children.

Objective: To study the prevalence of asthma and other allergic diseases in Angolan children. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.002DOI Listing
February 2019
1 Read

The short-term effects of cold spells on pediatric outpatient admission for allergic rhinitis in Hefei, China.

Sci Total Environ 2019 Jan 22;664:374-380. Epub 2019 Jan 22.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui 230032, China. Electronic address:

Background: Some studies have reported that cold weather is associated with the development of allergic rhinitis (AR), but the study of extreme cold temperatures and AR is scarced. This study was conducted to find out the optimal definition of the cold spells in Hefei and to explore the relationship between cold spells and childhood AR, further to identify potential susceptible populations.

Methods: Data of daily AR, meteorological variables and air pollutants from January 1, 2014 to December 31, 2016 were collected in Hefei. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.237DOI Listing
January 2019
1 Read

Diagnosing and managing allergic conjunctivitis in childhood: the allergist's perspective.

Pediatr Allergy Immunol 2019 Feb 11. Epub 2019 Feb 11.

CHU Clermont-Ferrand. Consultation d'Ophtalmologie et Allergologie de l'enfant, Unité d'Allergologie de l'enfant, CHU Estaing, 63003, Clermont-Ferrand Cedex1, France.

Allergic conjunctivitis (AC) in childhood often poses problems of diagnosis and management for the allergist. We present the salient points concerning the diagnosis and treatment of ocular allergy (OA) emerging from a large cohort survey conducted jointly in the departments of ophthalmology and paediatric allergy in a French teaching hospital. Seasonal acute conjunctivitis (SAC) is a common disorder and not overly difficult to diagnose and treat when associated with rhinitis leading to allergic rhinoconjunctivitis. Read More

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http://dx.doi.org/10.1111/pai.13035DOI Listing
February 2019
1 Read

Untreated allergic rhinitis is a major risk factor contributing to motorcar accidents.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1111/all.13741DOI Listing
February 2019
1 Read

Effect of the Fexofenadine on the expression of HRH-1 and HRH-4 receptor in Peripheral Blood Mononuclear Cell isolated from children with diagnosed allergy - in vitro study Short communication.

J Pharm Pharm Sci 2019 ;22(1):93-97

Department of Biology and Biotechnology, University of Warmia and Mazury, Oczapowskiego 1A Street, 10-719 Olsztyn, Poland.

Purpose: Fexofenadine (FXF) is the active metabolite of terfenadine with selective peripheral H1 receptor antagonist activity. FXF is a third-generation antihistamine, non-sedating, rapid and very long acting used in symptoms associated with allergic diseases such as allergic rhinitis, asthma and dermatitis. The pleiotropic effects of histamine are mediated by four types of receptors that belong to the G-protein-coupled receptor family: histamine H1 receptor (HRH-1), histamine H2 receptor, histamine H3 receptor, and histamine H4 receptor. Read More

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http://dx.doi.org/10.18433/jpps29971DOI Listing
January 2019
2 Reads

Omalizumab and unmet needs in severe asthma and allergic comorbidities in Japanese children.

Asia Pac Allergy 2019 Jan 22;9(1):e7. Epub 2019 Jan 22.

University of Manchester, Manchester, UK.

Childhood asthma is one condition within a family of allergic diseases, which includes allergic rhinitis, atopic dermatitis, and food allergy, among others. Omalizumab is an anti-IgE antibody therapy that was approved in Japan for children with asthma and added to the Japanese pediatric asthma guidelines in 2017. This review highlights the Japanese clinical perspectives in pediatric allergic asthma, and consideration for allergic comorbidities, and reflects on omalizumab clinical trials in progress to present comprehensive future opportunities. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365659PMC
January 2019
1 Read

Minimal clinically important difference for the rhinoconjunctivitis quality of life questionnaire in allergic rhinitis in Thai population.

Asia Pac Allergy 2019 Jan 22;9(1):e6. Epub 2019 Jan 22.

Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Clinical measurement of the severity of allergic rhinitis (AR) can be assessed by symptoms score and patient quality of life (QoL). The magnitude of change in both symptoms and patient QoL should be considered in the management of AR.

Objective: The aim of this study was to determine the minimal clinically important difference (MCID) in AR in Thai population. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365662PMC
January 2019
1 Read

A case of anhidrotic ectodermal dysplasia presenting with pyrexia, atopic eczema, and food allergy.

Asia Pac Allergy 2019 Jan 14;9(1):e3. Epub 2019 Jan 14.

Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan.

Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and atopic eczema. The patient was a 11-month-old boy admitted to our hospital with pyrexia for 2 weeks. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365661PMC
January 2019
1 Read

Stepwise approach towards adoption of allergen immunotherapy for allergic rhinitis and asthma patients in daily practice in Belgium: a BelSACI-Abeforcal-EUFOREA statement.

Clin Transl Allergy 2019 4;9. Epub 2019 Feb 4.

1ENT Clinical Department, University Hospital Leuven, Kapucijnenvoer 33, 3000 Louvain, Belgium.

Allergic rhinitis (AR) affects 23-30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontrolled. Allergen immunotherapy (AIT) has been shown to improve the level of control up to 84% of patients being controlled by AIT. Read More

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http://dx.doi.org/10.1186/s13601-019-0243-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360767PMC
February 2019
1 Read

An osteoclastogenesis system, the RANKL/RANK signaling pathway contributes to aggravated allergic inflammation.

Br J Pharmacol 2019 Feb 9. Epub 2019 Feb 9.

Division of Food and Pharmaceutical Engineering, Biochip Research Center and Inflammatory Diseases Research Center, Hoseo University, Asan, Chungnam, 31499, Republic of Korea.

Background And Purpose: As an osteoclast differentiation factor, receptor activator of nuclear factor-κB ligand (RANKL) is produced by various immune cells and is suspected in the pathogenesis of osteoporosis and inflammation. Although RANKL isbroadly expressed in most immune cells and tissues, it is not clear how this might affect allergic inflammation.

Experimental Approach: The roles of RANKL in allergic rhinitis (AR) were analyzed in an ovalbumin (OVA)-induced AR animal model, human subjects, and ahuman mast cell. Read More

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http://dx.doi.org/10.1111/bph.14615DOI Listing
February 2019
2 Reads

The Portuguese version of Rhinitis and Asthma Patient's Perspective (RAPP): Validation and assessment.

Pulmonology 2019 Feb 5. Epub 2019 Feb 5.

Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Background: Allergic rhinitis (AR) and asthma are two common chronic diseases that often coexist. There is a need for a validated tool to evaluate HRQoL of Portuguese speakers with asthma and/or rhinitis patients in clinical practice.

Objectives: To adapt and validate RhinAsthma Patient Perspective (RAPP) in Portuguese. Read More

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http://dx.doi.org/10.1016/j.pulmoe.2018.10.009DOI Listing
February 2019
1 Read

MicroRNA-181a and microRNA-155 are involved in the regulation of the differentiation and function of regulatory T cells in allergic rhinitis children.

Pediatr Allergy Immunol 2019 Feb 8. Epub 2019 Feb 8.

Department of Respiratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China.

Background: Regulatory T cells (Tregs) play central roles in limiting airway allergic inflammation and preventing inappropriate Th2 responses to environmental allergens. This study aims to evaluate the role of miR-181a and miR-155 in the regulation of the differentiation and function of Tregs through both in vivo and in vitro studies.

Methods: The CD4 T cell and Tregs were purified from peripheral blood mononuclear cells (PBMCs) in allergic rhinitis (AR) children, respectively. Read More

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http://dx.doi.org/10.1111/pai.13038DOI Listing
February 2019
1 Read

Association between antibiotic treatment during pregnancy & infancy and the development of allergic diseases.

Pediatr Allergy Immunol 2019 Feb 8. Epub 2019 Feb 8.

University Children's Hospital Zurich, Switzerland.

Background: Allergies are a serious public health issue and prevalences are rising worldwide. The role of antibiotics in the development of allergies has repeatedly been discussed, as results remain inconsistent. The aim of this study was to investigate the association between pre- & postnatal antibiotic exposure and subsequent development of allergies (atopic dermatitis, food allergy, asthma, atopic sensitization and allergic rhinitis). Read More

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http://doi.wiley.com/10.1111/pai.13039
Publisher Site
http://dx.doi.org/10.1111/pai.13039DOI Listing
February 2019
3 Reads

Clinical and immunological differences between asymptomatic HDM-sensitized and HDM-allergic rhinitis patients.

Clin Exp Allergy 2019 Feb 7. Epub 2019 Feb 7.

University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia.

Background: Confirmation of the clinical relevance of sensitisation is important for the diagnosis of allergic rhinitis.

Objective: To investigate the usefulness of an in vitro basophil activation test and component-resolved diagnosis in distinguishing between symptomatic allergic rhinitis patients and asymptomatic sensitization to house dust mites (HDMs).

Methods: Thirty-six subjects with a positive skin prick test (SPT) for HDM were divided into a symptomatic (n=17) and an asymptomatic (n=19) group on the basis of their clinical history and a nasal provocation test. Read More

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http://dx.doi.org/10.1111/cea.13361DOI Listing
February 2019
1 Read

Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort.

Pediatr Allergy Immunol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatric Pneumology and Immunology, Charite Medical University, Berlin, Germany.

Background: Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. Read More

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http://dx.doi.org/10.1111/pai.13036DOI Listing
February 2019
3 Reads

The association between allergic rhinitis and otitis media: A national representative sample of in South Korean children.

Authors:
Haewon Byeon

Sci Rep 2019 Feb 7;9(1):1610. Epub 2019 Feb 7.

Department of Speech Language Pathology, College of Health Science, Honam University, Gwangju, Republic of Korea.

Although many studies have reported that allergic rhinitis is an independent risk factor highly related to otitis media in children, there is still lack of epidemiological studies on demographics. The objective of this study was to identify if allergic rhinitis was an independent risk factor for otitis media in children aged between 7 and 12 years by using the nationwide survey data representing the local population of South Korea. This is a secondary study based on the ENT examination data (eg. Read More

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http://dx.doi.org/10.1038/s41598-018-38369-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367416PMC
February 2019
1 Read
5.078 Impact Factor

Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort.

J Pediatr 2019 Feb 4. Epub 2019 Feb 4.

Child Health and Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada; University Health Network, Toronto, Ontario, Canada. Electronic address:

Objective: To determine the lifetime prevalence of allergies in childhood nephrotic syndrome, the seasonality of presentation and relapses, and the impact of allergies on subsequent relapses.

Study Design: In a longitudinal cohort of children with nephrotic syndrome (ages 1-18 years), assessment for allergic diseases was conducted using the validated and modified version of the International Study of Asthma and Allergies in Childhood questionnaire at enrollment. Outcomes included frequently relapsing nephrotic syndrome, relapse rates, and the relapse-free duration after initial steroid therapy. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.048DOI Listing
February 2019
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Health-related quality of life varies in different respiratory disorders: a multi-case control population based study.

BMC Pulm Med 2019 Feb 7;19(1):32. Epub 2019 Feb 7.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, c/o Istituti Biologici II, Strada Le Grazie 8, 37134, Verona, Italy.

Background And Objective: Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB).

Methods: Controls (n = 328) and cases of NAR (n = 95), AR (n = 163), CB (n = 48), CA (n = 224), PA (n = 126) and COPD (n = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. Read More

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http://dx.doi.org/10.1186/s12890-019-0796-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367788PMC
February 2019
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Mind the gaps: clinical trial concepts to address unanswered questions in aeroallergen immunotherapy. An NIAID/AHRQ Workshop.

J Allergy Clin Immunol 2019 Feb 4. Epub 2019 Feb 4.

Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

The Agency for Healthcare Research and Quality and the National Institute of Allergy and Infectious Diseases organized a workshop to develop trial concepts that could improve the usage and effectiveness of aeroallergen immunotherapy (AAIT). Expert groups were formed to accomplish the following tasks: 1) Propose a study design to compare effectiveness and safety of subcutaneous versus sublingual AAIT; 2) Propose a study design to compare effectiveness and safety of AAIT using one or a few allergens vs all or most allergens to which a patient is sensitized; 3) Propose a study design to determine whether AAIT can alter the progression of childhood allergic airways disease; 4) Propose a study design to determine the optimal dose and duration of AAIT to achieve maximal effectiveness with acceptable safety. Study designs were presented by the workgroups, extensively discussed at the workshop and revised for this report. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.032DOI Listing
February 2019
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Time and age trends in smoking cessation in Europe.

PLoS One 2019 7;14(2):e0211976. Epub 2019 Feb 7.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.

Background: Smoking is the main risk factor for most of the leading causes of death. Cessation is the single most important step that smokers can take to improve their health. With the aim of informing policy makers about decisions on future tobacco control strategies, we estimated time and age trends in smoking cessation in Europe between 1980 and 2010. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211976PLOS
February 2019
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Fast up-dosing with a birch allergoid is safe and well tolerated in allergic rhinitis patients with or without asthma.

Immunotherapy 2019 Feb;11(3):177-187

Department for Children & Adolescents, Division for Allergology, Pneumology & Cystic Fibrosis, University Hospital Goethe University, Frankfurt am Main, 60590, Germany.

Aim: Subcutaneous immunotherapy is effective in treating allergic rhinoconjunctivitis and asthma, but is still inconvenient when heavy schedules are used. A faster dose escalation is desirable.

Materials & Methods: In this open-label, Phase II trial, 130 adults were randomized 1:1 to receive a birch pollen allergoid subcutaneous immunotherapy. Read More

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http://dx.doi.org/10.2217/imt-2018-0143DOI Listing
February 2019
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[Prevalence and risk factors for sleep-disordered breathing in chilean schoolchildren].

Rev Chil Pediatr 2018 Dec;89(6):718-725

Departamento de Cardiología Pediátrica y Enfermedades Respiratorias del Niño, División de Pediatría, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Objectives: To describe the prevalence of sleep-disordered breathing (SDB) in Chilean schoolchil dren and study associated risk factors.

Patients And Method: We carried out a transversal and des criptive study. Questionnaires were sent to the parents of children attending first year of elementary school in the Metropolitan Region (Santiago), the Biobío Region (Concepción, Chillán, Yumbel) and the Magallanes Region (Porvenir and Puerto Natales). Read More

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http://dx.doi.org/10.4067/S0370-41062018005000902DOI Listing
December 2018
2 Reads

[Aeroallergens causing rhinoconjunctivitis].

Rev Med Chil 2018 Sep;146(9):994-1000

Fundación de Aerobiología, Medioambiente y Salud, Santiago, Chile.

Background: Allergic rhinoconjunctivitis (ARC) has a prevalence of 30% in industrialized countries. For an accurate diagnosis and treatment, it is crucial to identify the causative aeroallergen.

Aim: To evaluate aeroallergen sensitization in adults with ARC in the city of Temuco, Chile. Read More

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http://dx.doi.org/10.4067/s0034-98872018000900994DOI Listing
September 2018

Mechanisms of Action of Probiotics.

Adv Nutr 2019 Jan;10(suppl_1):S49-S66

Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Armilla, Granada, Spain.

Probiotics are living microorganisms that confer health benefits to the host when administered in adequate amounts; however, dead bacteria and their components can also exhibit probiotic properties. Bifidobacterium and strains of lactic acid bacteria are the most widely used bacteria that exhibit probiotic properties and are included in many functional foods and dietary supplements. Probiotics have been shown to prevent and ameliorate the course of digestive disorders such as acute, nosocomial, and antibiotic-associated diarrhea; allergic disorders such as atopic dermatitis (eczema) and allergic rhinitis in infants; and Clostridium difficile-associated diarrhea and some inflammatory bowel disorders in adults. Read More

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https://academic.oup.com/advances/article/10/suppl_1/S49/530
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http://dx.doi.org/10.1093/advances/nmy063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363529PMC
January 2019
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Mining Social Media Data to Assess the Risk of Skin and Soft Tissue Infections from Allergen Immunotherapy.

J Allergy Clin Immunol 2019 Feb 2. Epub 2019 Feb 2.

Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

Background: Allergen immunotherapy (AIT) treatment for allergic rhinitis and asthma is used by 2.6 million Americans annually. Clinical and sterility testing studies identify no risk of contamination or infection from extracts prepared using recommended aseptic techniques, but regulatory concerns persist. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.029DOI Listing
February 2019
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[Nasal irrigation: opportunities and disadvantages].

Vestn Otorinolaringol 2018 ;83(6):76-80

Federal State Budgetary Institution 'Otorhinolaryngology Clinical Research Center' of the Federal Medico-Biological Agency, Moscow, Russia, 123182.

Relevance: Despite the widespread use of nasal irrigation in routine medical practice and a significant list of salt solution for nasal irrigation on the pharmaceutical market, contradictions remain in understanding of process essence, when salt solution acts on the mucous membrane of nasal cavity and evaluation of their effectiveness.

Aim: analysis of current data of frequency, methods and efficiency of systematic nasal irrigation and effect of salt solution at the mucous membrane of nasal cavity.

Results: In review the authors generalized and analyzed recent information about meaning of nasal irrigation for upper respiratory tract disease, about role of nasal mucus at maintaining homeostasis in nasal cavity and initial respiratory tract in general. Read More

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http://dx.doi.org/10.17116/otorino20188306176DOI Listing
January 2018
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Prevalence of symptoms of asthma and allergic rhinitis in children in Southern Brazil: a ten-year monitoring study.

J Asthma 2019 Feb 5:1-8. Epub 2019 Feb 5.

b Universidade Federal de Ciências da Saúde de Porto Alegre, Programa de Pós-Graduação em Patologia , Porto Alegre , RS , Brazil.

Objective: This study analyzes and describes trends in prevalence of asthma and rhinitis in children 6-7 years old living in Santo Ângelo, Brazil, by comparing data from 2007, 2012, and 2017.

Methods: The ISAAC (International Study of Asthma and Allergies in Childhood) standardized written questionnaire was used in a three cross-sectional survey. The questionnaire was applied between March and May of 2007, 2012 and 2017. Read More

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http://dx.doi.org/10.1080/02770903.2019.1573253DOI Listing
February 2019
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Differential Diagnosis of Churg-Strauss Syndrome with Tingling Sensation and Weakness of the Lower Extremities.

Anesth Pain Med 2018 Dec 28;8(6):e84179. Epub 2018 Nov 28.

Department of Internal Medicine, Division of Rheumatology, Jeju National University Hospital, Jeju, Korea.

Introduction: Churg-Strauss syndrome (CSS; or eosinophilic granulomatosis with polyangiitis) is an extremely rare autoimmune condition characterized by hypereosinophilia and vasculitis of small or medium-sized blood vessels, occurring in patients with asthma and allergic rhinitis.

Case Presentation: A 47-year-old man (height, 175.8 cm and weight, 74. Read More

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http://dx.doi.org/10.5812/aapm.84179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347737PMC
December 2018
1 Read