32,383 results match your criteria Rhinitis Allergic

Allergic Rhinitis Due To the Ornamental Plant Sansevieria Trifasciata.

J Investig Allergol Clin Immunol 2021 May 11. Epub 2021 May 11.

Roxall España, R&D Department, Bilbao, Vizcaya, Spain.

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The Role of CD40 in Allergic Rhinitis and Airway Remodelling.

Mediators Inflamm 2021 23;2021:6694109. Epub 2021 Apr 23.

Department of Otolaryngology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: Allergic rhinitis (AR) affects millions of people and is lack of effective treatment. CD40 is an important costimulatory molecule in immunity. However, few studies have focused on the role of CD40 in AR. Read More

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Protective effect of miR-138-5p inhibition modified human mesenchymal stem cell on ovalbumin-induced allergic rhinitis and asthma syndrome.

J Cell Mol Med 2021 May 11. Epub 2021 May 11.

Department of International Clinic, Qingdao Municipal Hospital, Qingdao, China.

The objective of the study is to evaluate the protective effects of human mesenchymal stem cells (hMSCs) modified with miR-138-5p inhibitor against the allergic rhinitis and asthma syndrome (ARAS). MiR-138-5p or negative control was transfected into hMSCs, and fluorescence-activated cell sorting was used to evaluate hMSC surface markers. Quantitative real-time PCR (qRT-PCR) was used to evaluate miR-138-5p, SIRT1, caspase-3, IL-6, IL-1β and TNF-α levels after TNF-α and IL-6 stimulations. Read More

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Sensitisation patterns and allergy outcomes in pregnant women living in the urban area.

Allergy Asthma Clin Immunol 2021 May 10;17(1):46. Epub 2021 May 10.

1st Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical University, ul. Chalubinskiego 2a, 50-368, Wroclaw, Poland.

Background: Worldwide, allergy affects more than one billion people, with particularly rising prevalence in industrialised areas. Specifically, young adults appear to be predominantly targeted for an allergy diagnosis. Allergic diseases in pregnancy are mainly pre-existing but could also occur de novo. Read More

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One march, many paths: Insights into allergic march trajectories.

Ann Allergy Asthma Immunol 2021 May 7. Epub 2021 May 7.

Division of Allergy and Immunology and Center for Pediatric Eosinophilic Disorders, Children's Hospital of Philadelphia; Institute for Immunology and Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address:

Objective: The classical allergic march model posits that atopy begins in infancy with atopic dermatitis and progresses to asthma and allergic rhinitis in a subset of individuals. The growing prevalence and severity of allergic diseases has prompted renewed interest in refining this model. This review outlines epidemiologic evidence for the existence of allergic march trajectories (distinct paths of atopy development in individuals), reviews the roles that genetics, environment, and disease endotypes play in determining trajectory outcomes, and discusses the clinical utility of the trajectory model. Read More

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Future of Allergic Rhinitis Management.

Ann Allergy Asthma Immunol 2021 May 7. Epub 2021 May 7.

Allergy Research Unit, Kingston Health Sciences Center - KGH Site, Kingston, ON, Canada; Department of Medicine, Queen's University, Kingston, ON, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. Electronic address:

Objective: To present a comprehensive, clinically focused scoping review of therapeutic agents and practices comprising the future of allergic rhinitis (AR) management.

Data Sources: A review of the published literature was performed using the PubMed database, published abstracts and virtual presentations from scientific meetings, and posted results on ClinicalTrials.gov. Read More

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Role of Bilateral Inferior Turbinoplasty as an Adjunct to Septoplasty in Improving Nasal Obstruction and Subjective Performance in Patients With Deviated Nasal Septum Associated With Allergic Rhinitis: An Interventional, Prospective Study.

Ear Nose Throat J 2021 May 10:1455613211015440. Epub 2021 May 10.

Department of Community Medicine, Bankura Sammilani Medical College and Hospital, Bankura, West Bengal, India.

Background: Patients with nasal obstruction due to deviated nasal septum (DNS) often have allergic rhinitis (AR) as contributing factor. When optimal medical therapy for AR fails, septoplasty alone may not adequately treat nasal obstruction. Therefore, with bilateral inferior turbinate hypertrophy representing long-standing AR, adding bilateral inferior turbinoplasty (BIT) to septoplasty might be beneficial. Read More

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An Exhausted Phenotype of T 2-Cells Is Primed by Allergen Exposure,But Not Reinforced by Allergen-specific Immunotherapy.

Allergy 2021 May 9. Epub 2021 May 9.

Center of Allergy & Environment (ZAUM), Technical University of Munichand Helmholtz Center Munich, German Research Center for Environmental Health, Germany, Members of the German Center of Lung Research (DZL), CPC-M, Munich, Germany,and Member of the Helmholtz I&I Initiative, Germany.

Background: Studies show that proallergic T 2-cells decrease after successful allergen-specific immunotherapy (AIT). It is likely that iatrogenic administration of allergens drives these cells to exhaustion due to chronic T cell receptor stimulation. This study aimed to investigate the exhaustion of T cells in connection with allergenexposure during AIT in mice and two independent patient cohorts. Read More

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Retinoic Acid Correlates with Reduced Serum IL-10 And TGF-β in Allergic Rhinitis.

Rep Biochem Mol Biol 2021 Jan;9(4):399-407

Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Retinoic acid (RA) plays a key role in naïve T cell differentiation into FOXP3+ Treg cell in the respiratory airways. The present study aims to investigate RA and Treg-related cytokine serum levels, salivary IgA levels, FOXP3 and IL-4 gene expression, and the relationships between RA serum levels and Treg-related cytokines in allergic rhinitis (AR) patients and healthy controls.

Methods: Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37 AR patients and 30 age- and sex-matched healthy controls. Read More

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January 2021

One Hundred Ten Years of Allergen Immunotherapy: A Broad Look Into the Future.

J Allergy Clin Immunol Pract 2021 May;9(5):1791-1803

Vice Presidents Research Group, Paul-Ehrlich-Institut, Langen, Germany.

Allergen immunotherapy (AIT) is the only disease-modifying treatment option for patients with type 1-mediated allergic diseases such as allergic rhinitis/rhinoconjunctivitis with/without allergic asthma. Although many innovations have been developed since the first clinical report of Noon et al in 1911, the improvement of clinical efficacy and tolerability of this treatment is still an important unmet need. Hence, much progress has been made in the characterization of the cell types, cytokines, and intracellular signaling events involved in the development, maintenance, and regulation of allergic reactions, and also in the understanding of the mechanisms of tolerance induction in AIT. Read More

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Expression and clinical significance of VCAM-1, IL-6, and IL-17A in patients with allergic rhinitis.

Ann Palliat Med 2021 Apr;10(4):4516-4522

Department of Otorhinolaryngology and Sleep Medicine Center, West China School of Public Health and West China Forth Hospital, Sichuan University, Chengdu, China.

Background: Allergic rhinitis is a chronic inflammatory disease with a high incidence, affecting the quality of life of patients. The aim of the present study was to explore the expression and clinical significance of vascular endothelial cell adhesion molecule-1 (VCAM-1), interleukin (IL)-6, and IL-17A in patients with allergic rhinitis.

Methods: A total of 180 patients with allergic rhinitis, who were admitted to our hospital from March 2017 to March 2020, were enrolled as the observation group. Read More

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Increased Risk of Atrial Fibrillation in Patients with Atopic Triad: A Nationwide Population-Based Study.

J Allergy Clin Immunol Pract 2021 May 6. Epub 2021 May 6.

Department of Internal Medicine, Seoul National University Hospital, Republic of Korea.

Background: Despite a sharp increase in the global prevalence of allergy over the past decade, the relationship between multiple atopic conditions and atrial fibrillation (AF) has not been fully elucidated.

Objective: To determine whether there is an association between atopic diseases and AF and to examine the effect of multiple atopic diseases on the incidence of AF.

Methods: This retrospective population-based study used the database from the 2009 National Health Insurance Services-Health Screening Cohort in Korea. Read More

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Clemastine attenuates AD-like pathology in an AD model mouse via enhancing mTOR-mediated autophagy.

Exp Neurol 2021 May 6:113742. Epub 2021 May 6.

Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, Jiangsu Province 215021, China. Electronic address:

Alzheimer's disease (AD) is a neurodegenerative disorder with limited available drugs for treatment. Enhancing autophagy attenuates AD pathology in various AD model mice. Thus, development of potential drugs which enhance autophagy may bring beneficial effects in AD therapy. Read More

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Therapeutic effects of melatonin on an ovalbumin-induced allergic rhinitis model in rats.

Auris Nasus Larynx 2021 May 5. Epub 2021 May 5.

Department of Pharmacology, Dokuz Eylul University, School of Medicine, Izmir 35340, Turkey.

Objective: We aimed to investigate the therapeutic effects of melatonin in an experimental AR model.

Methods: Thirty-two Wistar rats were randomised into four groups (n = 8 each). The experimental AR model was established in the saline (SF), ethanol, and melatonin groups via intraperitoneal (i. Read More

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Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s.

J Allergy Clin Immunol 2021 May;147(5):1531-1547

Department of Immunology, Mayo Clinic, Rochester, Minn; Division of Allergy, Asthma, and Immunology and Department of Medicine, Mayo Clinic, Scottsdale, Ariz. Electronic address:

In the 12 years since the discovery of innate lymphoid cells (ILCs), our knowledge of their immunobiology has expanded rapidly. Group 2 ILCs (ILC2s) respond rapidly to allergen exposure and environmental insults in mucosal organs, producing type 2 cytokines. Early studies showed that epithelium-derived cytokines activate ILC2s, resulting in eosinophilia, mucus hypersecretion, and remodeling of mucosal tissues. Read More

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Georgian Med News 2021 Mar(312):78-82

1V. Karazin Kharkiv National University, School of Medicine; 2SI "Institute of Health of Children and Adolescents of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.

In this study was to investigate the сoexistence of diabetes mellitus type 1 with other chronic pathology in children and adolescents and their impact on the course of diabetes mellitus type 1 (DM1). The 88 children from 3 to 17 years who had DM1 were observed. The study was conducted by survey with the aim of finding risk factors and associated comorbidties with a questionnaire-based, objective-subjective study. Read More

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Association of Gasdermin B Gene GSDMB Polymorphisms with Risk of Allergic Diseases.

Biochem Genet 2021 May 8. Epub 2021 May 8.

Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.

The GSDMB gene encodes gasdermin B from the family of gasdermin domain-containing proteins involved in various cellular processes related to tumor development and progression, such as differentiation, cell cycle control and apoptosis. Previously, we conducted GWAS on asthma in the Volga-Ural region of Russia and found SNPs associated with asthma with genome-wide significance (rs9303277, rs8067378, rs2290400, rs7216389, rs4795405) and located in the chromosomal region 17q12-q21, which contains IKZF3 (IKAROS family zinc finger 3), ZPBP2 (zona pellucida binding protein-like), GSDMB (gasdermin B), ORMDL3 (orosomucoid 1-like 3) and LRRC3C (leucine-rich repeat-containing 3C) genes. In the present study, we investigated the association of SNPs of the GSDMB gene with the development of various allergic diseases and their combined manifestations in individuals of Russian, Tatar and Bashkir ethnic origin. Read More

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DEP-induced ZEB2 promotes nasal polyp formation via epithelial-to-mesenchymal transition.

J Allergy Clin Immunol 2021 May 3. Epub 2021 May 3.

Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea; Ischemic/hypoxic disease institute, Seoul National University College of Medicine, Seoul, Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea;; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea. Electronic address:

Background: Diesel exhaust particles (DEP) are associated with the prevalence and exacerbation of allergic respiratory diseases, including allergic rhinitis and allergic asthma. However, DEP-induced mechanistic pathways promoting upper airway disease and their clinical implications remain unclear OBJECTIVE: We sought to investigate the mechanisms by which DEP exposure contributes to nasal polyposis using human-derived epithelial cells and a murine nasal polyp (NP) model.

Methods: Gene set enrichment and weighted gene co-expression network analyses were performed. Read More

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Botulinum toxin for chronic rhinitis: A systematic review and meta-analysis.

Int Forum Allergy Rhinol 2021 May 6. Epub 2021 May 6.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Botulinum toxin type A (BTX-A) is a potential treatment for chronic rhinitis. This study aimed to assess the effectiveness and safety of BTX-A in treating patients with chronic rhinitis.

Methods: Systematic searches of MEDLINE, Scopus, and EMBASE databases were performed. Read More

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High endothelial venules (HEVs) in immunity, inflammation and cancer.

Angiogenesis 2021 May 6. Epub 2021 May 6.

Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France.

High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high levels of lymphocyte extravasation from the blood, HEVs play an essential role in lymphocyte recirculation and immune surveillance for foreign invaders (bacterial and viral infections) and alterations in the body's own cells (neoantigens in cancer). The HEV network expands during inflammation in immune-stimulated LNs and is profoundly remodeled in metastatic and tumor-draining LNs. Read More

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SARS-CoV-2 infection in patients with atopic dermatitis: a cross-sectional study.

Br J Dermatol 2021 May 6. Epub 2021 May 6.

University of California Irvine School of Medicine, Department of Dermatology, Irvine, CA, U.S.A.

Dear Editor, SARS-CoV-2 disproportionately impacts certain populations with inflammatory conditions which have an elevated risk of respiratory comorbidities. Additionally, atopic dermatitis (AD) is associated with other atopic diseases, such as allergic rhinitis and asthma, which increases the risk of respiratory infections and predisposes patients to neuropsychiatric disorders. There are limited studies evaluating the role of systemic medications on risk of infection. Read More

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The economic burden of allergic comorbidities in pediatric severe asthma.

Pediatr Allergy Immunol 2021 May 5. Epub 2021 May 5.

AP-HP, Hôpital Necker-Enfants Malades, Department of Pediatric Pulmonology and Allergy, Paris, France.

Severe asthma (SA) affects less than 5% of the pediatric asthma population but is considered to account for approximately half of total pediatric asthma healthcare costs. Allergic comorbidities, including food allergies (FA) and allergic rhinitis (AR), are frequent in children with SA (1). The presence of FA and AR increases asthma severity (1-6) and medication use (4-6). Read More

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1,25-Dihydroxyvitamin D3 Supplementation during Pregnancy Is Associated with Allergic Rhinitis in the Offspring by Modulating Immunity.

J Immunol Res 2021 14;2021:6638119. Epub 2021 Apr 14.

Department of Otolaryngology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.

Background: Maternal supplementation with 1,25-dihydroxyvitamin D3 (VD3) has immunologic effects on the developing fetus through multiple pathways. This study was aimed at investigating the effects of VD3 supplementation on immune dysregulation in the offspring during allergic rhinitis.

Methods: Different doses of VD3 as well as control were given to pregnant female mice. Read More

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Efficacy of Selective Vidian Neurectomy for Allergic Rhinitis Combined with Chronic Rhinosinusitis.

ORL J Otorhinolaryngol Relat Spec 2021 May 5:1-8. Epub 2021 May 5.

Department of Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital, Capital Medical University, Beijing, China.

Objective: The aim of this study was to investigate the efficacy of endoscopic selective vidian neurectomy in the treatment of severe persistent allergic rhinitis (AR) combined with chronic rhinosinusitis (CRS) with nasal polyps (ARwCRSwNP).

Methods: One hundred thirty patients with moderate to severe persistent ARwCRSwNP were enrolled at Xuanwu Hospital, Capital Medical University, from September 2015 to September 2017. Patients were divided into 2 groups. Read More

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Nasal nitric oxide testing for allergic rhinitis patients: Systematic review and meta-analysis.

Immun Inflamm Dis 2021 May 5. Epub 2021 May 5.

Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: Nasal nitric oxide (nNO) levels in allergic rhinitis (AR), healthy people or nonallergic rhinitis (NAR) have shown contradicting results in previous studies. By meta-analysis, we reviewed studies that measured nNO in AR patients to assess nNO's ability to discriminate AR from healthy people or NAR.

Methods: We systematically searched PubMed, Cochrane, Embase, Ovid, Web of Science, Wanfang Data, CNKI until December 15, 2020. Read More

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Immunoallergic disorders in the elderly.

Eur Ann Allergy Clin Immunol 2021 May 5. Epub 2021 May 5.

Department of Immunoallergology, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

Summary: Although allergic diseases have become increasingly prevalent in the elderly, there are few data on this population. Through a retrospective analysis of the electronic medical records of patients aged 65 years and above followed in our Immunoallergology Unit, we aimed to characterize the immunoallergic diseases of the elderly. The most common disorders were respiratory diseases (n = 185; 50%), mucocutaneous diseases (n = 113; 31%), drug allergy (n = 31; 8%), food allergy (n = 9; 2%), and anaphylaxis (n = 9; 2%). Read More

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Association Between Microbiota and Nasal Mucosal Diseases in terms of Immunity.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea.

The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. Read More

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Research Progress on the SERPINE1 Protein and Chronic Inflammatory Diseases of the Upper Respiratory Tract: A Literature Review.

Int Arch Allergy Immunol 2021 May 4:1-6. Epub 2021 May 4.

Department of Otolaryngology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

SERPINE1 protein is one important member of the serine proteinase inhibitor E superfamily that plays a crucial role in the fibrinolytic system. It has been identified which is related to chronic inflammatory lung diseases like allergic asthma and lung fibrosis. Recently, researchers have focused on the impact of SERPINE1 and its genetic polymorphisms on inflammatory diseases of the upper respiratory tract. Read More

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Higenamine alleviates allergic rhinitis by activating AKT1 and suppressing the EGFR/JAK2/c-JUN signaling.

Phytomedicine 2021 Jun 20;86:153565. Epub 2021 Apr 20.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Guangzhou Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou 510515, China; Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology, Guangzhou 510515, China. Electronic address:

Background: Allergic rhinitis (AR) is an inflammatory, immunoglobulin E (IgE)-mediated disease characterized by the typical symptoms of sneezing, rhinorrhea, nasal itching, and congestion. Higenamine (HG) is a plant-based alkaloid, possesses a wide range of activities, including vascular and tracheal relaxation, antioxidative, antiapoptotic, anti-inflammatory, and immunomodulatory activities. So far, the effect and the underlying mechanism of HG on AR have not been studied. Read More

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Impact of Air Pollution on Allergic Rhinitis and Asthma: Consensus Statement by Indian Academy of Pediatrics.

Indian Pediatr 2021 May 3. Epub 2021 May 3.

President 2020, Indian Academy of Pediatrics.

Justification: Rising air pollution is an ever-growing threat to many human diseases. Poor air quality has been directly correlated with respiratory allergies with a disproportionate affection among the pediatric age group. A clear understanding of common air pollutants and their potential contribution in allergic rhinitis and asthma is lacking. Read More

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