29,631 results match your criteria Rhinitis Allergic


Is Quantitative sIgE Serology Suitable for Distinguishing Between Silent Sensitization and Allergic Rhinitis to Dermatophagoides pteronyssinus?

J Investig Allergol Clin Immunol 2019 Apr;29(2):124-131

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Hospital, Munich, Germany.

Background And Objective: An increasing number of studies have recently discussed whether provocation tests might be replaced by specific IgE serology in patients sensitized to airborne allergens. Objective: Our study aimed to analyze the concordance between a nasal provocation test with Dermatophagoides pteronyssinus and specific IgE measurements based on real-life data.

Methods: We retrospectively analyzed concordance between the result of the provocation test and the IgE titer for house dust mite components and extracts in 223 patients with proven sensitization to D pteronyssinus. Read More

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http://dx.doi.org/10.18176/jiaci.0299DOI Listing

Asthma phenotypes and associated comorbidities in a large cohort of adolescents in Israel.

J Asthma 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Medical Corps, IDF , Israel.

Objectives: Asthma is a multifactorial, heterogeneous, complex and common chronic respiratory disease driven by diverse mechanisms. Although asthma presents various clinical forms with different levels of severity, it is unclear whether asthma severities are a consequence of disease management or varied etiologies. We sought to investigate this question. Read More

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http://dx.doi.org/10.1080/02770903.2019.1604743DOI Listing

Clinical Efficacy of Allergen-Specific Immunotherapy from Patient and Physician Perspectives.

Yonsei Med J 2019 May;60(5):446-453

Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Purpose: Allergen-specific immunotherapy (AIT) is the only curative treatment for allergic diseases, but a few allergic patients receive AIT. In this multicenter cross-sectional study, we aimed to explore patient and physician perspectives on AIT through a questionnaire survey.

Materials And Methods: Allergic patients who received subcutaneous immunotherapy for at least 1 year were asked to answer a questionnaire developed by an expert panel of allergen and immunotherapy workgroup in Korea. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.5.446DOI Listing

The complex pathophysiology of allergic rhinitis: scientific rationale for the development of an alternative treatment option.

Allergy Asthma Clin Immunol 2019 16;15:24. Epub 2019 Apr 16.

5Department of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.

Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes. Read More

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http://dx.doi.org/10.1186/s13223-018-0314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469109PMC

Association between Dipeptidyl Peptidase-4 Inhibitors and Allergic Rhinitis in Asian Patients with Diabetes.

Int J Environ Res Public Health 2019 Apr 12;16(8). Epub 2019 Apr 12.

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404, Taiwan.

In this retrospective study, we attempted to evaluate the association between dipeptidyl peptidase-4 (DPP-4) inhibitors and allergic rhinitis in patients with diabetes. We analyzed the Longitudinal Health Insurance Database 2000 subdatabase. Our study population included patients with type 2 diabetes (ICD-9-CM 250) between 2009 and 2012, and the study groups were DPP-4 inhibitor users and nonusers. Read More

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http://dx.doi.org/10.3390/ijerph16081323DOI Listing

[MASK (Mobile Airways Sentinel Network). ARIA's comprehensive solution for mobile app for the multimorbidity of allergic rhinitis and asthma].

Rev Alerg Mex 2019 Jan-Mar;66(1):140-146

Médica Sur, Centro de Excelencia en Asma y alergia, Ciudad de México, México.

The vast majority of patients with allergic rhinitis (AR) do not receive the proper management which is recommended by the guidelines, but they frequently self-medicate. MASK (Mobile Airways Sentinel Network) is an integral part of a project that is supported by the European Union against chronic diseases and focused on active and healthy aging. MASK represents the third phase of ARIA (Allergic Rhinitis and its Impact on Asthma), in which, by using a mobile application in a smart device, the objective is to guide the patient in the control of his/her multi-morbidity, AR and/or allergic conjunctivitis (AC) and/or asthma. Read More

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http://dx.doi.org/10.29262/ram.v66i1.578DOI Listing

[Cross-sectional survey about the prevalence of allergic rhinitis in Argentina: Study PARA].

Rev Alerg Mex 2019 Jan-Mar;66(1):55-64

Asociación Argentina de Alergia e Inmunología Clínica, Buenos Aires, Argentina.

Background: There are very few studies about the prevalence of allergic rhinitis in Argentina.

Objective: To determine the prevalence of allergic rhinitis in a population of inhabitants between the ages of 5 and 44 in Argentina.

Methods: A cross-sectional national study in which a self-reported questionnaire was used. Read More

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http://dx.doi.org/10.29262/ram.v66i1.543DOI Listing

[Diagnosis of allergic sensitization in patients with allergic rhinitis and asthma in a tropical environment].

Rev Alerg Mex 2019 Jan-Mar;66(1):44-54

Clínica El Ávila, Servicio de Alergia e Inmunología Clínica, Caracas, Venezuela.

Background: Few studies in tropical developing countries have utilized molecular diagnosis to characterize allergen-specific responses to aeroallergens.

Objective: To investigate the in vivo and in vitro responses of IgE antibodies to inhalant allergens in allergic patients with rhinitis and/or asthma.

Methods: A prospective study in which patients with allergic rhinitis and/or asthma were included. Read More

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http://dx.doi.org/10.29262/ram.v66i1.570DOI Listing

[Sensitivity and specificity of the modified epicutaneous patch test in the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus].

Rev Alerg Mex 2019 Jan-Mar;66(1):38-43

Universidad Autónoma de Puebla, Hospital Universitario de Puebla, Servicio de Alergia e Inmunología Clínica, Puebla, Puebla, México.

Background: The skin prick test is recognized as the gold standard for the specific diagnosis of allergy.

Objective: To determine the sensitivity and specificity of the epicutaneous patch test that has been modified for the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus.

Methods: An observational, interpretative, prolective, and transversal study. Read More

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http://dx.doi.org/10.29262/ram.v66i1.533DOI Listing

[Allergy to food in adults with allergic respiratory diseases: prevalence and clinical manifestations].

Rev Alerg Mex 2019 Jan-Mar;66(1):1-8

Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Alergia e Inmunología Clínica, Guadalajara, México.

Background: Food allergy is considered a typical problem in the pediatric population, however, cases occur in adults more frequently.

Objective: To determine the prevalence of food allergy in patients with allergic rhinitis and asthma; as well as the foods and symptoms most related to said problem.

Methods: Through a cross-sectional study, the information of 257 adults with asthma or allergic rhinitis was analyzed. Read More

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http://revistaalergia.mx/ojs/index.php/ram/article/view/400
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http://dx.doi.org/10.29262/ram.v66i1.400DOI Listing
April 2019
3 Reads

Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Asthma and allergic rhinitis (AR) are chronic inflammatory diseases of airway and affect the disease severity each other.

Objective: We performed this study to examine whether nasal saline irrigation (NSI) improves bronchial hyperresponsiveness and clinical parameters in children with asthma and allergic rhinitis (AR).

Methods: We enrolled 20 children with AR and asthma aged between 6-18 years. Read More

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http://dx.doi.org/10.12932/AP-070918-0403DOI Listing

Patients with atopy exhibit reduced cortisol awakening response but not cortisol concentrations during the rest of the day.

Immunol Res 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.

It has been documented that cortisol release in response to acute stressors is reduced in patients with atopic dermatitis, allergic rhinitis, and other atopic diseases compared to that in healthy subjects. We aimed to test the hypothesis that atopic patients exert reduced salivary cortisol awakening response (CAR) in comparison with healthy subjects. The hypothesis was tested on a stressful and a relax day selected subjectively. Read More

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http://dx.doi.org/10.1007/s12026-019-09076-wDOI Listing

SCIT Versus SLIT: Which One Do You Recommend, Doc?

Am J Med Sci 2019 May 10;357(5):442-447. Epub 2019 Feb 10.

Department of Otolaryngology, Emory University, Atlanta, Georgia.

Allergic rhinitis is a prevalent condition that has a significant impact on the quality of life of many patients. When initial therapy fails to control the symptoms, allergen immunotherapy (AIT) has been suggested as an option by the Joint Task Force on Practice Parameters. The 2 main forms of AIT are via subcutaneous and sublingual routes, called subcutaneous immunotherapy and sublingual immunotherapy, respectively. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.004DOI Listing

Real-life safety of 5-grass pollen tablet in 5-to-9-year-old children with allergic rhinoconjunctivitis.

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Pediatric Pneumology and Allergology unit, Necker-Enfants Malades Hospital, Paris, France; Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1016/j.anai.2019.04.011DOI Listing

Leukotriene Receptor Antagonist Addition to H1-Antihistamine Is Effective for Treating Allergic Rhinitis: A Systematic Review and Meta-analysis.

Am J Rhinol Allergy 2019 Apr 22:1945892419844459. Epub 2019 Apr 22.

1 Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Histamine and leukotriene are released after being triggered by allergen exposure. The combination of leukotriene receptor antagonist (LTRA) and H1-antihistamine (AH) is utilized to control the allergic rhinitis (AR) symptoms after the failure of either AH or LTRA.

Objective: This study aimed to investigate the effects of the combination of H1-antihistamine and leukotriene receptor antagonist (AH-LTRA) in patients with AR. Read More

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http://dx.doi.org/10.1177/1945892419844459DOI Listing

The allergen-specificity of allergen immunotherapy - doubt no more.

Authors:
Stephen R Durham

Allergy 2019 Apr 20. Epub 2019 Apr 20.

National Heart and Lung Institute, Imperial College London, Dovehouse Street, London.

The ARIA-GA2LEN collaboration published a guide for the design and evaluation of randomised controlled trials of allergen immunotherapy for allergic rhinitis. Several problems in were identified. For example, the severity/persistence of seasonal symptoms in subjects during allergen immunotherapy was noted to be much lower than in trials of pharmacotherapy. Read More

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http://dx.doi.org/10.1111/all.13826DOI Listing

Predictors of reversible airway obstruction with omalizumab in severe asthma: a real-life study.

Ther Adv Respir Dis 2019 Jan-Dec;13:1753466619841274

Department of Medical Sciences, University of Turin, Corso Dogliotti 14 10126 Turin, Italy.

Background: Omalizumab may modulate airway remodeling in severe asthma. Using forced expiratory volume in 1 second (FEV) as a surrogate of airway remodeling, we aimed to investigate if an omalizumab add-on in severe allergic asthma may lead to a persistent reversal of airway obstruction and to evaluate the potential biomarkers of airway obstruction reversibility.

Methods: Data were collected before (T0) and after omalizumab add-on for 1 year (T1, 32 patients), 2 years (T2, 26 patients) and 4 years (T4, 13 patients). Read More

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http://dx.doi.org/10.1177/1753466619841274DOI Listing

Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents.

Front Pharmacol 2019 29;10:294. Epub 2019 Mar 29.

Menzies Health Institute Queensland, School of Medical Science, Griffith University, Southport, QLD, Australia.

Allergic rhinitis (AR) is a chronic upper respiratory disease estimated to affect between 10 and 40% of the worldwide population. The mechanisms underlying AR are highly complex and involve multiple immune cells, mediators, and cytokines. As such, the development of a single drug to treat allergic inflammation and/or symptoms is confounded by the complexity of the disease pathophysiology. Read More

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http://dx.doi.org/10.3389/fphar.2019.00294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455085PMC

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey.

Int Arch Allergy Immunol 2019 Apr 18:1-8. Epub 2019 Apr 18.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Background: Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known.

Objective: To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well as drug and healthcare costs.

Methods: Nationwide Allergy Barometer Survey was carried out in the Finnish pharmacies during 1 week in September 2016. Read More

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http://dx.doi.org/10.1159/000498861DOI Listing
April 2019
1 Read

Prevalence of atopy and allergic rhinitis in patients with adult non-cystic fibrosis bronchiectasis

Turk J Med Sci 2019 Apr 18;49(2):551-557. Epub 2019 Apr 18.

Background/aim: Non-cystic fibrosis bronchiectasis (non-CF BR) is common in developing countries.Limited data are available regarding the impact of atopy, and no data are available regarding allergic rhinitis in patients with adult bronchiectasis.The aim of this study was to evaluate the prevalence of atopy and allergic rhinitis in the clinical conditions of patients with BR. Read More

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http://dx.doi.org/10.3906/sag-1807-229DOI Listing
April 2019
1 Read

Chronic pesticide mixture exposure including paraquat and respiratory outcomes among Colombian farmers.

Ind Health 2019 Apr 18. Epub 2019 Apr 18.

Public Health Department, Medicine and Health Sciences School, Universidad del Rosario, Colombia.

This study explored the potential association between chronic exposure to pesticide mixtures including paraquat and respiratory outcomes among Colombian farmers. Sociodemographic and occupational data, respiratory symptoms and spirometric data were collected. Paraquat in spot urine samples were quantified with solid-phase extraction high-performance liquid chromatography. Read More

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http://dx.doi.org/10.2486/indhealth.2018-0111DOI Listing
April 2019
1 Read

Effectiveness of Acupuncturing at the Sphenopalatine Ganglion Acupoint Alone for Treatment of Allergic Rhinitis: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2019 12;2019:6478102. Epub 2019 Mar 12.

School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.

Aims: To evaluate the efficiency of acupuncturing at the sphenopalatine ganglion acupoint alone for treatment of allergic rhinitis.

Design: A total of ten online databases were searched to find studies published up to Jan. 2018. Read More

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http://dx.doi.org/10.1155/2019/6478102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434301PMC
March 2019
1 Read

Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study).

Clin Exp Otorhinolaryngol 2019 Apr 18. Epub 2019 Apr 18.

Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.

Objectives: There is a great deal of interest in the possibility that environmental factors may influence the risk of developing allergic rhinitis (AR) in early life. We investigated the simultaneous effects of mode of delivery and duration of breastfeeding on the development of AR in children.

Methods: Data from 1,374 children participating in the Allergic Rhinitis Cohort Study for kids (ARCO-kids study) was analyzed. Read More

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http://dx.doi.org/10.21053/ceo.2018.01781DOI Listing
April 2019
2 Reads

[The effect of NK-1R-siRNA on expression of inflammatory factors in allergic rhinitis].

Authors:
H Wang J Wu R X Zhang

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;54(4):280-285

Department of Otolaryngology, Huadong Hospital, Fudan University, Shanghai 200040, China.

To explore the effect of neurokinin-1 receptor small interfering RNA (NK-1R-siRNA) on the expression of inflammation factors in allergic rhinitis (AR). Twenty-four male SD rats were divided into three groups randomly (by random number table methord): NK-1R-siRNA group, negative control siRNA (NC-siRNA) group and saline group, with 8 rats in each group. SD rats were sensitized and challenged with ovalbumin (OVA) to induce AR. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.04.008DOI Listing
April 2019
2 Reads

Identifying indoor air Penicillium species: a challenge for allergic patients.

J Med Microbiol 2019 Apr 16. Epub 2019 Apr 16.

2 Department of Parasitology Mycology, University Hospital of Besançon, Besançon, France.

Purpose: Penicillium is the most common mould isolated in housing. Penicillium chrysogenum is the only species tested by prick test or serology for allergic patients. The American Institute of Medicine has accepted Penicillium as an aetiological agent of rhinitis in children and adults and as an asthma agent in children. Read More

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http://dx.doi.org/10.1099/jmm.0.000960DOI Listing
April 2019
7 Reads

The role of invariant T cells in inflammation of the skin and airways.

Semin Immunopathol 2019 Apr 15. Epub 2019 Apr 15.

Centre for Cancer Biology, The University of South Australia and SA Pathology, North Terrace, Adelaide, SA, 5000, Australia.

Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells express T cell receptors of very limited diversity. iNKT and MAIT cells recognise antigens presented by the MHC class 1-like monomorphic molecules CD1d and MR1, respectively. Read More

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http://link.springer.com/10.1007/s00281-019-00740-9
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http://dx.doi.org/10.1007/s00281-019-00740-9DOI Listing
April 2019
2 Reads

Severity and prevalence of allergic rhinitis among school children, Jazan Region Saudi Arabia.

J Family Med Prim Care 2019 Feb;8(2):663-668

Department of Internal Medicine, Jazan University, Jeddah, Saudi Arabia.

Background: Allergic diseases such as allergic rhinitis (AR) represent a global health problem, affecting 10-25% of the world population. There is clear evidence to support the concept that allergic diseases are influenced by genetic predisposition and environmental exposure.

Objectives: To assess the severity and prevalence of AR among school children in Jazan Region, Saudi Arabia. Read More

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http://www.jfmpc.com/text.asp?2019/8/2/663/252993
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http://dx.doi.org/10.4103/jfmpc.jfmpc_294_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436248PMC
February 2019
3 Reads

IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms.

Clin Mol Allergy 2019 2;17. Epub 2019 Apr 2.

Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund University, Lund, Sweden.

Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Read More

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http://dx.doi.org/10.1186/s12948-019-0110-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444864PMC
April 2019
1 Read

Frequency of allergic sensitization to Can f 5 in North East Italy. An analysis of 1403 ISACs 112 (Component Resolved Diagnosis) collected retrospectively.

Eur Ann Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Postgraduate School of Respiratory Medicine. Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Summary: Recent studies have shown the increasing relevance of allergic sensitization to Can f 5, a prostatic kallicrein expressed in the prostate and detectable only in male dogs. The aim of the present study was to establish the frequency, level of sensitization and association with other dog allergens of Can f 5, as assessed by Component Resolved Diagnosis (CRD- ISAC 112, ThermoFisher Scientific, Uppsala, Sweden), in North East Italy. A total of 1403 CRD ISAC 112 were examined retrospectively. Read More

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.89DOI Listing
April 2019
1 Read

[Chronic rhinosinusitis of adults: new definition, new diagnosis].

Rev Prat 2019 Mar;69(3):274-278

Service ORL, Hôpitaux de Brabois, CHRU de Nancy ; EA 3450 DevAH, développement, adaptation et handicap, laboratoire de physiologie ; université de Lorraine, Vandoeuvre-lès-Nancy, France.

Chronic rhinosinusitis of adults: new definition, new diagnosis. The three-nose theory, which is based on evolution and development of the nose, seems useful for a better understanding of chronic rhinosinusitis (CRS). The nose seems in fact to be composed of three noses (one olfactory, one respiratory and one sinusal nose), each of them being able to be affected by specific diseases. Read More

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March 2019
1 Read

Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):772S-799S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: During the Pregnancy and Birth to 24 Months Project, the USDA and Department of Health and Human Services initiated a review of evidence on diet and health in these populations.

Objectives: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding prior to infant formula introduction, 4) feeding a lower versus higher intensity of human milk to mixed-fed infants, and 5) feeding a higher intensity of human milk by bottle versus breast with food allergies, allergic rhinitis, atopic dermatitis, and asthma.

Methods: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. Read More

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http://dx.doi.org/10.1093/ajcn/nqy283DOI Listing
March 2019
1 Read
6.770 Impact Factor

Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):890S-934S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: Nutrition during infancy and toddlerhood may influence health and disease prevention across the life span. Complementary feeding (CF) starts when human milk or infant formula is complemented by other foods and beverages, beginning during infancy and continuing to age 24 mo.

Objectives: The aim of this study was to describe systematic reviews conducted for the USDA and the Department of Health and Human Services Pregnancy and Birth to 24 Months Project to answer the following question: What is the relationship between the timing of the introduction of complementary foods and beverages (CFBs), or types and amounts of CFBs consumed, and the development of food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis?

Methods: The literature was searched using 4 databases (CINAHL, Cochrane, Embase, PubMed) to identify articles published from January 1980 to February 2017 that met predetermined inclusion criteria. Read More

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http://dx.doi.org/10.1093/ajcn/nqy220DOI Listing
March 2019
3 Reads
6.770 Impact Factor

Powder Cellulose in Allergic Rhinitis Management: Relevance of in vitro Findings to Real-Life Safety - Author's Reply.

Int Arch Allergy Immunol 2019 Apr 12;179(1):19-21. Epub 2019 Apr 12.

Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China,

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http://dx.doi.org/10.1159/000497116DOI Listing
April 2019
5 Reads

Specific Immunoglobulin G4 and Immunoglobulin E Titers to Common Food Antigens in Sera of Children With Allergic Rhinitis.

Altern Ther Health Med 2018 Nov;24(6):38-45

Context: Allergic rhinitis is a chronic disease that usually affects children. Its etiology has been investigated for years.

Objective: The aim of the study was to evaluate the diagnostic value of immunoglobulin G4 (IgG4) against common food allergens, to determine the correlation between it and immunoglobulin E (IgE), and to evaluate the role of IgG4 (ie, whether its presence should be considered to be a significant factor that induces hypersensitivity or whether an effector role in allergic rhinitis could be attributed to it). Read More

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November 2018
1 Read

Construction of an irreversible allergic rhinitis-induced olfactory loss mouse model.

Biochem Biophys Res Commun 2019 Apr 10. Epub 2019 Apr 10.

Department of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

Clinical data show that part of patients with sinonasal diseases suffered from olfactory dysfunction, especially with allergic rhinitis (AR) and chronic rhinosinusitis (CRS). However, the mechanisms responsible for AR-induced olfactory loss are still largely unknown. Because of the difficulty to obtain human olfactory mucosa, an AR-induced olfactory loss animal model needs to be constructed to clarify the mechanism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193049
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http://dx.doi.org/10.1016/j.bbrc.2019.03.110DOI Listing
April 2019
5 Reads

Allergic rhinitis increases the risk of incident panic disorder among young individuals: A nationwide population-based cohort study in Taiwan.

J Affect Disord 2019 Apr 9;252:60-67. Epub 2019 Apr 9.

Tsaotun Psychiatric Center, Ministry of Health and Welfare, 542 No.161, Yu-Pin Rd, Caotun Township, Nantou, Taiwan, R.O.C.. Electronic address:

Background: Studies have reported an association between allergy and panic disorder. However, few studies have explored the relationship between allergic rhinitis and panic disorder. Previous studies were limited by cross-sectional study designs, self-reported symptoms, absence of matched controls, and lack of consideration of the influence of steroid and comorbidities. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.037DOI Listing
April 2019
1 Read

Tumor necrosis factor alpha and interleukin-5 inhibit olfactory regeneration via apoptosis of olfactory sphere cells in mice models of allergic rhinitis.

Clin Exp Allergy 2019 Apr 13. Epub 2019 Apr 13.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea.

Background: Olfactory dysfunction is frequently experienced by patients with allergic rhinitis. It is thought to result from structural and functional changes occurring in the olfactory mucosa caused by inflammation. However, the current understanding of the pathophysiology of olfactory dysfunction in allergic rhinitis remains unclear. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13401
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http://dx.doi.org/10.1111/cea.13401DOI Listing
April 2019
5 Reads

Ebastine in the treatment of allergic rhinitis and urticaria: 30 years of clinical studies and real-world experience.

Authors:
J Sastre

J Investig Allergol Clin Immunol 2019 Apr 12. Epub 2019 Apr 12.

Department of Allergy, Fundación Jimenez Diaz, Madrid. CIBERES, Instituto Carlos III. Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Histamine, acting predominantly via the H1-receptor, is an important mediator of the symptoms of allergy, and H1-antihistamines, which stabilise the receptor in its inactive form, are the treatment of choice for some chronic allergic conditions. Ebastine is a well-established oral second-generation H1-antihistamine. It is administered once daily at a dose of 10-20 mg and is available as a standard tablet and also as a fast-dissolving tablet that disintegrates in the mouth. Read More

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http://dx.doi.org/10.18176/jiaci.0401DOI Listing
April 2019
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Prevalence of food allergy among schoolchildren in Kuwait and its association with the coexistence and severity of asthma, rhinitis, and eczema: A cross-sectional study.

Authors:
Ali H Ziyab

World Allergy Organ J 2019 30;12(4):100024. Epub 2019 Mar 30.

Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Background: Food allergy (FA) is a common public health problem that affects both children and adults. Empirical knowledge of the burden of FA in Kuwait is limited. This study sought to estimate the prevalence of FA among schoolchildren in Kuwait and assess associations between FA and the coexistence and severity of asthma, rhinitis, and eczema. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441753PMC
March 2019
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Restoration of immune suppressor function of regulatory B cells collected from patients with allergic rhinitis with Chinese medical formula Yupingfeng San.

Am J Transl Res 2019 15;11(3):1635-1643. Epub 2019 Mar 15.

Research Center of Allergy and Immunology, School of Medicine, Shenzhen University Shenzhen, China.

Immune dysregulation, such as defects in immune suppressor function, plays an important role in the pathogenesis of many immune disorders including allergic rhinitis (AR). Some Chinese traditional medical formulae have an immune regulatory function. This study aims to restore the immune suppressor function in regulatory B cells (Bregs) collected from AR patients with a Chinese medical formula, Yupingfeng San (YPFS). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456564PMC
March 2019
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[The correlation between adenoid hypertrophy and allergic rhinitis].

Authors:
C Cao Y Xu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):381-384

Adenoid tissue are the major constituent of Waldeyer's ring which are physiologically natural defense mechanism of the body against inhaled allergens and microorganisms.In all children, the volume of the adenoid increases with age with a maximal volume in the age group of 5-6 years, followed by a gradual decrease in volume by the age of 8-9 years.Allergic rhinitis is a non-infectious chronic inflammatory disease of nasal mucosa mediated by immunoglobulin E and involved by a variety of immunocompetent cells (T, B lymphocytes, mast cells, etc. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.023DOI Listing
April 2019
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[Analysis of sensitization spectrum and clinical features of children with adenoid hypertrophy and perennial rhinitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):351-353

Department of Allergy, Peking Union Medical College Hospital, Bejing, 100730, China.

To investigate the sensitization spectrum and clinical features of children with adenoid hypertrophy and perennial rhinitis.A total of 121 children with adenoidal hypertrophy and perennial rhinitis were enrolled in the ENT Department of the Children's Hospital of the Capital Institute of Pediatrics and the Allergy Department of Peking Union Medical College Hospital from July to October in 2017. Nasopharyngoscopy was performed, and specific IgE were measured by blood sampling, and the sensitization spectrum and clinical characteristics of the children were analyzed. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2019.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.015DOI Listing
April 2019
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[The efficacy of sublingual immunotherapy for allergic rhinitis and the predictive role of cytokines in its therapeutic effect].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):332-336

Shanxi Medical University, Taiyuan, 030001, China.

The study aimed to investigate the efficacy of sublingual immunotherapy(SLIT) in treatment of adult allergic rhinitis, and to explore the predictive role of baseline serum cytokine levels in its therapeutic effect.Sixty patients with moderatesevere perennial AR sensitized with house dust mites were treated for 2 years. The SLIT group(n=30) were treated with standardized dust mite vaccine SLIT and conventional drugs, and the control group(n=30) were treated with placebo and conventional drugs. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.011DOI Listing
April 2019
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[Expression of LC3 and ECP in allergic rhinitis and their significance].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):322-325

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.

To investigate the expression of microtubuleassociated protein 1 light chain 3 beta(LC3) and eosinophil cationic protein in allergic rhinitis(AR) for further understanding of the pathogenesis of AR. Twenty cases of normal nasal mucosa and 20 cases of AR nasal mucosa were collected. Histological changes of nasal mucosa were examined by hematoxylin and eosin(HE) staining. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2019.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.009DOI Listing
April 2019
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Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China.

Int Arch Allergy Immunol 2019 Apr 10:1-6. Epub 2019 Apr 10.

Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, China.

Background: Nasal polyps are a common health problem that can significantly impact the quality of life.

Objective: To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China.

Methods: A retrospective cohort of 323 patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis without nasal polyps (CRSsNP) and CRSwNP in Xijing Hospital was studied between January 5, 2011, and January 4, 2015. Read More

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https://www.karger.com/Article/FullText/497384
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http://dx.doi.org/10.1159/000497384DOI Listing
April 2019
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Sensitization to Cat: When Is Nasal Challenge Needed?

Int Arch Allergy Immunol 2019 Apr 10:1-6. Epub 2019 Apr 10.

Al Rashed Allergy Centre, Kuwait, Kuwait.

Introduction: Although the skin prick test (SPT) is a reliable diagnostic tool in perennial allergic rhinitis (PER) for patients allergic to cats, the minimum necessary SPT wheal size required to distinguish cat sensitization from true allergy remains controversial. The cat nasal challenge test (cNCT) could be considered the gold standard for detecting true cat allergy.

Aims: To assess the difference in the frequency of cNCT positivity between cat owners and non-owners and to determine an appropriate cut-off level for SPT wheal size in detecting positive cNCT in PER patients who are candidates for allergen immunotherapy (AIT) with cat allergen extracts. Read More

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https://www.karger.com/Article/FullText/496835
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http://dx.doi.org/10.1159/000496835DOI Listing
April 2019
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Allergen-specific immunotherapy enhances CD8 CD25 CD137 regulatory T cells and decreases nasal nitric oxide.

Pediatr Allergy Immunol 2019 Apr 9. Epub 2019 Apr 9.

Clinical Immunological Center, China Medical University Hospital, College of Medicine, China Medical University, Taichung, Taiwan.

Background: 4-1BB (CD137), a member of the inducible tumor necrosis factor receptor (TNFR) family, is expressed on regulatory T (Treg) cells and regulates Treg cells to control allergic inflammation. Pam3CSK4, a synthetic TLR2 ligand that can expand CD8+ Treg function, is a promising adjuvant for allergen immunotherapy (IT). We examined whether Dermatophagoides pteronyssinus (Der p) IT and Pam3CSK4 could enhance CD8+CD25+CD137+ Treg suppressive function to decrease nasal nitric oxide (nNO) levels. Read More

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http://dx.doi.org/10.1111/pai.13061DOI Listing
April 2019
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The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy.

Int J Mol Sci 2019 Apr 8;20(7). Epub 2019 Apr 8.

Division of Bioregulatory Pharmacology, Department of Pharmacology, Iwate Medical University, Morioka 028-3694, Japan.

Mast cells play a critical role in the pathogenesis of allergic asthma. Histamine is a central mediator released from mast cells through allergic reactions. Histamine plays a role in airway obstruction via smooth muscle contraction, bronchial secretion, and airway mucosal edema. Read More

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https://www.mdpi.com/1422-0067/20/7/1733
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http://dx.doi.org/10.3390/ijms20071733DOI Listing
April 2019
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Clinical Insights About Topical Treatment of Mild-to-Moderate Pediatric and Adult Atopic Dermatitis.

J Cutan Med Surg 2019 Apr 9:1203475419843108. Epub 2019 Apr 9.

9 Division of Dermatology, BC Children's Hospital; University of British Columbia, Vancouver, Canada.

Atopic dermatitis (AD) is a chronic inflammatory skin condition, also referred to as atopic eczema, that is identified by itching and recurrent eczematous lesions. It often starts in infancy where it affects up to 20% of children but is also highly prevalent in adults. AD inflicts a significant psychosocial burden on patients and their families and increases the risk of other immune-mediated inflammatory conditions, such as asthma and allergic rhinitis, food allergy, and mental health disorders. Read More

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http://dx.doi.org/10.1177/1203475419843108DOI Listing
April 2019
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Intranasal Azelastine and Fluticasone as Combination Therapy for Allergic Rhinitis: Systematic Review and Meta-Analysis.

Otolaryngol Head Neck Surg 2019 Apr 9:194599819841883. Epub 2019 Apr 9.

1 Department of Otolaryngology-Head and Neck Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Objective: Combination therapy with intranasal azelastine and fluticasone propionate is an option for treatment of allergic rhinitis. This systematic review and meta-analysis examines existing literature to determine efficacy in treating allergic rhinitis compared to monotherapy.

Data Sources: The PubMed, EMBASE, Cochrane, and MEDLINE databases were systematically searched for randomized controlled trials using AzeFlu nasal spray. Read More

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http://dx.doi.org/10.1177/0194599819841883DOI Listing
April 2019
2 Reads