7,982 results match your criteria Rheumatology Oxford [Journal]


The effects of fruit consumption in patients with hyperuricaemia or gout.

Rheumatology (Oxford) 2019 Apr 19. Epub 2019 Apr 19.

Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA.

The consumption of fructose has gained increased attention as a potential cause of hyperuricaemia since fructose metabolism produces urate as a byproduct. In addition to sucrose and high fructose corn syrup, fresh fruits also contain fructose, suggesting that patients with hyperuricaemia or gout might also avoid fresh fruit. However, the effect of fruits is complex. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez128DOI Listing
April 2019
2 Reads

Polypharmacy is associated with treatment response and serious adverse events: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Rheumatology (Oxford) 2019 Apr 14. Epub 2019 Apr 14.

Department of Inflammation Biology, School of Immunology & Microbial Sciences.

Objective: To evaluate whether polypharmacy is associated with treatment response and serious adverse events (SAEs) in patients with RA using data from the British Society for Rheumatology Biologics Register (BSRBR-RA).

Methods: The BSRBR-RA is a prospective observational cohort study of biologic therapy starters and a DMARD comparator arm. A logistic regression model was used to calculate the odds of a EULAR 'good response' after 12 months of biologic therapy by medication count. Read More

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http://dx.doi.org/10.1093/rheumatology/kez037DOI Listing
April 2019
1 Read

A systematic review and meta-analysis of infection risk with small molecule JAK inhibitors in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Apr 14. Epub 2019 Apr 14.

Centre for Rheumatic Disease, Kings College London.

Objectives: To evaluate the risk of serious infection (SI) and herpes zoster (HZ) in rheumatoid arthritis patients receiving JAK inhibitors.

Methods: We conducted a systematic literature review and meta-analysis of phase II and III randomized controlled trials of tofacitinib (5 mg bid), baricitinib (4 mg od) and upadacitinib (15 mg od). Patient-exposure years were calculated. Read More

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http://dx.doi.org/10.1093/rheumatology/kez087DOI Listing
April 2019
1 Read

Using biologics safely.

Authors:
Ernest H Choy

Rheumatology (Oxford) 2019 Apr 14. Epub 2019 Apr 14.

CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1093/rheumatology/kez129DOI Listing

013 The role of B cell monotherapy in the treatment of auto-immune encephalitis.

Authors:
Clive Kelly

Rheumatology (Oxford) 2019 Apr 13. Epub 2019 Apr 13.

Medicine, Queen Elizabeth Hospital, Gateshead, UNITED KINGDOM.

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez145DOI Listing
April 2019
4 Reads

The role of stroma and epithelial cells in primary Sjögren's syndrome.

Rheumatology (Oxford) 2019 Mar 3. Epub 2019 Mar 3.

Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.

Primary SS (pSS) is a chronic autoimmune condition characterized by infiltration of the exocrine glands and systemic B cell hyperactivation. This glandular infiltration is associated with loss of glandular function, with pSS patients primarily presenting with severe dryness of the eyes and mouth. Within the affected glands, the infiltrating lymphocytes are organized in tertiary lymphoid structures. Read More

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http://dx.doi.org/10.1093/rheumatology/kez050DOI Listing
March 2019
2 Reads

Is a positive family history of spondyloarthritis relevant for diagnosing axial spondyloarthritis once HLA-B27 status is known?

Rheumatology (Oxford) 2019 Apr 1. Epub 2019 Apr 1.

Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.

Objectives: A positive family history (PFH) of spondyloarthritis, in particular a PFH of AS or acute anterior uveitis, is associated with HLA-B27 carriership in chronic back pain patients. As it is unknown, the study aimed to investigate if a PFH contributes to diagnosing axial spondyloarthritis (axSpA) once HLA-B27 status is known.

Methods: In axSpA-suspected patients from the Assessment of SpondyloArthritis international Society (ASAS), DEvenir des Spondyloarthropathies Indifférenciéés Récentes (DESIR) and SPondyloArthritis Caught Early (SPACE) cohorts, logistic regression analyses were performed with HLA-B27 status and PFH according to the ASAS definition (ASAS-PFH) as determinants and clinical axSpA diagnosis as outcome at baseline. Read More

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http://dx.doi.org/10.1093/rheumatology/kez095DOI Listing
April 2019
1 Read

An atypically located solitary gouty tophus.

Rheumatology (Oxford) 2019 Apr 1. Epub 2019 Apr 1.

Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore.

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http://dx.doi.org/10.1093/rheumatology/kez124DOI Listing

PR3-ANCA-associated vasculitis is associated with a specific motif in the peptide-binding cleft of HLA-DP molecules.

Rheumatology (Oxford) 2019 Apr 1. Epub 2019 Apr 1.

Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.

Objectives: This study aimed to characterize the association between HLA alleles and ANCA-associated vasculitis (AAV) in a genetically homogeneous population, and to analyse the contribution of specific HLA molecule amino acid sequences to the risk of AAV.

Methods: We included 187 Danish patients with AAV and 1070 healthy controls. All were HLA typed at two-field resolution. Read More

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http://dx.doi.org/10.1093/rheumatology/kez111DOI Listing

Autoantibodies to Mi-2 alpha and Mi-2 beta in patients with idiopathic inflammatory myopathy.

Rheumatology (Oxford) 2019 Apr 1. Epub 2019 Apr 1.

Research and Development, Inova Diagnostics, San Diego, CA, USA.

Objectives: The objective of this study was to compare the results obtained from different assays for the detection of anti-Mi-2 antibodies, which are important markers in the diagnosis of DM.

Methods: The study included 82 patients (68 females/14 males), most of whom had DM (n = 57), followed by PM (n = 16) and juvenile DM (n = 9). All samples were tested using a novel particle-based multi-analyte technology (PMAT) (Inova Diagnostics, research use only) in parallel with a line immunoassay (LIA: Euroimmun). Read More

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http://dx.doi.org/10.1093/rheumatology/kez092DOI Listing
April 2019
1 Read

A patient with a mediastinal mass and diffuse asymptomatic osteolytic lesions.

Rheumatology (Oxford) 2019 Apr 1. Epub 2019 Apr 1.

Rheumatology Service at Hospital Nossa Senhora da Conceição, Rio Grande do Sul, Brazil.

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http://dx.doi.org/10.1093/rheumatology/kez121DOI Listing
April 2019
1 Read

Comment on: Intravenous cyclophosphamide vs rituximab for the treatment of early diffuse scleroderma lung disease: open label, randomized, controlled trial: reply.

Rheumatology (Oxford) 2019 Apr 1. Epub 2019 Apr 1.

Department of Rheumatology, Institute of Postgraduate Medical Education and Research, Kolkata.

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http://dx.doi.org/10.1093/rheumatology/kez122DOI Listing
April 2019
2 Reads
4.475 Impact Factor

MicroRNA-21-5p as a novel therapeutic target for osteoarthritis.

Rheumatology (Oxford) 2019 Apr 1. Epub 2019 Apr 1.

Department of Orthopaedics, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Objective: Growing evidence indicates that microRNAs (miRNA) play a critical role in the pathogenesis of OA, and overexpressing or silencing miRNA expression in OA models can contribute to the development of miRNA-based therapeutics. The objective of this study was to determine whether intra-articular injection of miRNA can inhibit OA progression.

Methods: The miRNA expression profile was determined in OA cartilage tissues and controls. Read More

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http://dx.doi.org/10.1093/rheumatology/kez102DOI Listing
April 2019
3 Reads

Comment on: How to use bisphosphonates safely and optimally.

Rheumatology (Oxford) 2019 Mar 30. Epub 2019 Mar 30.

Department of Rheumatology, Altnagelvin Hospital, Londonderry, UK.

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http://dx.doi.org/10.1093/rheumatology/kez097DOI Listing
March 2019
2 Reads

Candida albicans tenosynovitis of the hand.

Rheumatology (Oxford) 2019 Mar 29. Epub 2019 Mar 29.

Rheumatology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/rheumatology/kez115DOI Listing
March 2019
2 Reads

Calprotectin discriminates septic arthritis from pseudogout and rheumatoid arthritis.

Rheumatology (Oxford) 2019 Mar 28. Epub 2019 Mar 28.

Infectious Diseases Unit, Centre Hospitalier Universitaire Grenoble Alpes.

Objective: We aimed to determine whether calprotectin and α-defensins could discriminate septic from other inflammatory arthritides.

Methods: Synovial fluids with a predominance of neutrophils from patients with septic arthritis, pseudogout and RA were prospectively collected. Neutrophil-related proteins calprotectin and human neutrophil α-defensins levels were assessed in synovial fluids. Read More

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http://dx.doi.org/10.1093/rheumatology/kez098DOI Listing
March 2019
3 Reads

Risk of relapse after discontinuation of tocilizumab therapy in giant cell arteritis.

Rheumatology (Oxford) 2019 Mar 26. Epub 2019 Mar 26.

Department of Rheumatology, Immunology and Allergology, University Hospital (Inselspital)University of Bern.

Objective: It is currently unknown how long GCA should be treated with tocilizumab. In the first randomized controlled trial, the biologic agent was stopped after 52 weeks. We therefore studied what proportion of patients relapsed, when relapses occurred and whether factors might predict relapse after tocilizumab treatment discontinuation. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez091DOI Listing
March 2019
10 Reads

Global analysis of protein expression in muscle tissues of dermatomyositis/polymyosisits patients demonstrated an association between dysferlin and human leucocyte antigen A.

Rheumatology (Oxford) 2019 Mar 25. Epub 2019 Mar 25.

Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, China.

Objectives: DM and PM are characterized by myofibre damage with inflammatory cell infiltration due to the strong expressions of MHC class I HLA-A and monocyte chemoattractant protein-1 (MCP-1). Dysferlin (DYSF) is a transmembrane glycoprotein that anchors in the sarcolemma of myofibres. DYSF mutation is closely associated with inherited myopathies. Read More

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http://dx.doi.org/10.1093/rheumatology/kez085DOI Listing
March 2019
1 Read

Increased risk of coronary heart disease among patients with idiopathic inflammatory myositis: a nationwide population study in Taiwan.

Rheumatology (Oxford) 2019 Mar 21. Epub 2019 Mar 21.

School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objective: To evaluate the risk of incident coronary heart disease (CHD) among patients with DM and PM in a general population context.

Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database containing records covering the years from 2000 to 2010. DM and PM were confined for the purposes of this study to those aged ⩾18 years who were eligible for the Taiwan catastrophic illness certificate. Read More

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http://dx.doi.org/10.1093/rheumatology/kez076DOI Listing
March 2019
6 Reads

The relationship of lymphoma and lupus-at least bidirectional.

Authors:
Marc Schmalzing

Rheumatology (Oxford) 2019 Mar 21. Epub 2019 Mar 21.

Department of Internal Medicine, Rheumatology and Clinical Immunology, University Clinic of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1093/rheumatology/kez088DOI Listing

Comment on: Familial Mediterranean fever: breaking all the (genetic) rules.

Authors:
Isabelle Touitou

Rheumatology (Oxford) 2019 Mar 21. Epub 2019 Mar 21.

Stem cells, Cellular Plasticity, Regenerative Medicine and Immunotherapies, INSERM, University of Montpellier.

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http://dx.doi.org/10.1093/rheumatology/kez086DOI Listing
March 2019
3 Reads

Determinants of diagnostic delay in axial spondyloarthritis: an analysis based on linked claims and patient-reported survey data.

Rheumatology (Oxford) 2019 Mar 21. Epub 2019 Mar 21.

Department of Gastroenterology, Infectiology and Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objectives: The objective of this study was to assess the current diagnostic delay in axial SpA (axSpA) and to analyse factors associated with it.

Methods: A stratified sample of subjects with a diagnosis of axSpA (International Classification of Diseases, 10th Revision code M45) was drawn from health insurance data in Germany and was questioned on disease-related, lifestyle and socio-economic characteristics. The diagnostic delay was calculated as the time from back pain onset until a diagnosis of axSpA. Read More

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http://dx.doi.org/10.1093/rheumatology/kez090DOI Listing
March 2019
1 Read

Comment on: Thymectomy in patients with myasthenia gravis increases the risk of autoimmune rheumatic diseases: a nationwide cohort study.

Rheumatology (Oxford) 2019 Mar 20. Epub 2019 Mar 20.

The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer, Israel.

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http://dx.doi.org/10.1093/rheumatology/kez093DOI Listing
March 2019
1 Read

The presence of anti-neutrophil extracellular trap antibody in patients with microscopic polyangiitis.

Rheumatology (Oxford) 2019 Mar 20. Epub 2019 Mar 20.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Objective: Although ANCA is the major autoantibody in patients with ANCA-associated vasculitis, previous studies have suggested the presence of anti-neutrophil extracellular trap (NET) antibody in patients with microscopic polyangiitis (MPA), one type of ANCA-associated vasculitis. In this study, we aimed to determine the prevalence and pathogenic role of anti-NET antibody (ANETA) in MPA.

Methods: We examined the presence or absence of ANETA in sera obtained from 19 MPA patients by indirect immunofluorescence. Read More

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http://dx.doi.org/10.1093/rheumatology/kez089DOI Listing
March 2019
1 Read

The autoantibody response to cyclic citrullinated collagen type II peptides in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Mar 19. Epub 2019 Mar 19.

Department of Medical Biochemistry and Biophysics, Section for Medical Inflammation Research, Karolinska Institutet, Stockholm, Sweden.

Objectives: The detection of anti-citrullinated peptide antibodies (ACPAs) is a serological hallmark of RA. Autoantibodies reactive with collagen type II (CII) are present in RA sera and synovial fluid and are potentially pathogenic. Here, we investigate the prevalence and specificity of the autoantibody responses to defined citrullinated cyclic peptides derived from CII in a China RA cohort. Read More

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http://dx.doi.org/10.1093/rheumatology/kez073DOI Listing
March 2019
3 Reads
4.475 Impact Factor

Drug-associated vasculitis occurring after treatment with pembrolizumab.

Rheumatology (Oxford) 2019 Mar 19. Epub 2019 Mar 19.

Division of Rheumatology, Mayo Clinic, Jacksonville, FL, USA.

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http://dx.doi.org/10.1093/rheumatology/kez051DOI Listing
March 2019
4 Reads
4.475 Impact Factor

Salivary gland ultrasonography in primary Sjögren's syndrome: opportunities and challenges.

Rheumatology (Oxford) 2019 Mar 19. Epub 2019 Mar 19.

Rheumatology Clinic, Department of Medical and Biological Sciences, Santa Maria della Misericordia University Hospital, Udine, Italy.

Salivary gland ultrasonography (SGUS) has an established role in detecting typical structural gland abnormalities in primary Sjögren's Syndrome (pSS). SGUS might be included in pSS classification and could be used as a prognostic and follow-up biomarker, but for this purpose additional efforts, new techniques and larger cohort studies are needed. HarmonicSS, an ongoing Horizon, EU-supported project in pSS, will apply artificial intelligence to SGUS in pSS. Read More

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http://dx.doi.org/10.1093/rheumatology/kez079DOI Listing
March 2019
1 Read

Association between socioeconomic status and comorbidities among patients with rheumatoid arthritis: results of a nationwide cross-sectional survey.

Rheumatology (Oxford) 2019 Mar 19. Epub 2019 Mar 19.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam.

Objectives: We examined the association between socioeconomic status (SES) and comorbidity distribution among patients with RA.

Methods: Information on comprehensive health status of 1088 RA patients (weighted n = 612 303) was obtained from the 2007-2015 Korea National Health and Nutrition Examination Survey database. SES components were household equivalence income, education and area of residence. Read More

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http://dx.doi.org/10.1093/rheumatology/kez081DOI Listing
March 2019
2 Reads

Primus inter pares: the choice of biologic drugs in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Mar 19. Epub 2019 Mar 19.

Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez101DOI Listing
March 2019
5 Reads

Orbital mass in ANCA-associated vasculitides: data on clinical, biological, radiological and histological presentation, therapeutic management, and outcome from 59 patients.

Rheumatology (Oxford) 2019 Mar 18. Epub 2019 Mar 18.

Department of Internal Medicine, National Referral Center for Systemic and Autoimmune Diseases, Hôpital de la Pitié-Salpêtrière, Paris.

Objective: Orbital mass is a rare and sight-threatening manifestation of ANCA-associated vasculitides, which remains a therapeutic challenge. We aimed to describe the presentation, therapeutic management and outcome of ANCA-associated vasculitides-related orbital mass.

Methods: We conducted a French nationwide retrospective study of patients with orbital mass in the setting of ANCA-associated vasculitides according to ACR criteria and/or Chapel Hill Consensus Conference definitions. Read More

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http://dx.doi.org/10.1093/rheumatology/kez071DOI Listing
March 2019
1 Read
4.475 Impact Factor

Comment on: A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Renal and Vascular Inflammation Section, Imperial College London, London, UK.

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http://dx.doi.org/10.1093/rheumatology/kez038DOI Listing

European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Objectives: IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic vasculitis in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning the appropriate diagnosis and treatment of IgAV in children. Accordingly, treatment regimens differ widely. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez041DOI Listing
March 2019
4 Reads

Measuring spinal mobility in early axial spondyloarthritis: does it matter?

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To investigate the frequency and order of impairment of spinal mobility measures (SMMs) and their cross-sectional and longitudinal usefulness in early axial spondyloarthritis.

Methods: SMMs measurements of patients from the DESIR (5-year data) and SPACE (2.6 (1. Read More

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http://dx.doi.org/10.1093/rheumatology/kez026DOI Listing
March 2019
3 Reads

Expanded circulating peripheral helper T cells in systemic lupus erythematosus: association with disease activity and B cell differentiation.

Rheumatology (Oxford) 2019 Mar 15. Epub 2019 Mar 15.

Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.

Objective: Peripheral helper T (TPH) cells are a recently identified Th cell subset that promotes B cell differentiation and antibody production in inflamed tissues. This study investigated circulating TPH cells to determine their involvement in systemic lupus erythematosus (SLE).

Methods: Peripheral blood mononuclear cells collected from SLE patients and healthy individuals were analysed. Read More

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http://dx.doi.org/10.1093/rheumatology/kez077DOI Listing
March 2019
3 Reads

Twenty-year scintigraphic follow-up of calcitonin versus zoledronic acid in Paget's disease of bones.

Rheumatology (Oxford) 2019 Mar 15. Epub 2019 Mar 15.

Rheumatology Department, 417 Army Share Fund Hospital (NIMTS), National and Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.1093/rheumatology/kez070DOI Listing
March 2019
1 Read

Comment on: A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.

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http://dx.doi.org/10.1093/rheumatology/kez036DOI Listing
March 2019
4.475 Impact Factor

A 74-year-old female with recurrent infections receiving methotrexate for rheumatoid arthritis.

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Pathology, Sidra Medicine, Doha, Qatar.

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/kez080DOI Listing
March 2019
2 Reads

Aspirin Triggered Resolvin D1 reduces inflammation and restores saliva secretion in a Sjögren's syndrome mouse model.

Rheumatology (Oxford) 2019 Mar 15. Epub 2019 Mar 15.

School of Dentistry, University of Utah, Salt Lake City, UT, USA.

Objectives: SS is characterized by chronic inflammation of the salivary glands leading to loss of secretory function, thereby suggesting specialized pro-resolving mediators targeting inflammation to be a viable option for treating SS. Previous studies demonstrated that aspirin-triggered resolvin D1 (AT-RvD1) prevents chronic inflammation and enhances saliva secretion in a SS-like mouse model when applied before disease onset. However, this therapy cannot be used in SS patients given that diagnosis occurs post-disease onset and no reliable screening methods exist. Read More

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http://dx.doi.org/10.1093/rheumatology/kez072DOI Listing
March 2019
4 Reads
4.475 Impact Factor

Safety and immunogenicity of tetanus/diphtheria vaccination in patients with rheumatic diseases-a prospective multi-centre cohort study.

Rheumatology (Oxford) 2019 Mar 15. Epub 2019 Mar 15.

Department of Public Health/Division of Infectious Diseases, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

Objectives: We aimed to assess the safety and immunogenicity of a diphtheria/tetanus vaccine booster dose in three different patient groups with rheumatic diseases on a variety of immunosuppressive/immunomodulatory medications compared with healthy controls (HCs).

Methods: We conducted a multi-centre prospective cohort study in Switzerland. We enrolled patients with RA, axial SpA/PsA, vasculitis (Behçet's disease, ANCA-associated vasculitis) and HCs. Read More

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http://dx.doi.org/10.1093/rheumatology/kez045DOI Listing
March 2019
1 Read

Epigenome-wide association study identifies Behçet's disease-associated methylation loci in Han Chinese.

Rheumatology (Oxford) 2019 Mar 12. Epub 2019 Mar 12.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing.

Objective: The aetiology of Behçet's disease (BD), known as a systemic vasculitis, is not completely understood. Increasing evidence suggests that aberrant DNA methylation may contribute to the pathogenesis of BD. The aim of this epigenome-wide association study was to identify BD-associated methylation loci in Han Chinese. Read More

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http://dx.doi.org/10.1093/rheumatology/kez043DOI Listing
March 2019
6 Reads

Comment on: Is early-onset primary Sjögren's syndrome a worse prognosis form of the disease? Reply.

Rheumatology (Oxford) 2019 Mar 11. Epub 2019 Mar 11.

Department of Internal Medicine, Claude Huriez Hospital, Univ. Lille, Lille cedex, France.

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http://dx.doi.org/10.1093/rheumatology/kez074DOI Listing
March 2019
2 Reads
4.475 Impact Factor

Comment on: Is early-onset primary Sjögren's syndrome a worse prognosis form of the disease?

Rheumatology (Oxford) 2019 Mar 11. Epub 2019 Mar 11.

Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1093/rheumatology/kez082DOI Listing
March 2019
4 Reads

Development and validation of a patient-reported gout attack intensity score for use in gout clinical studies.

Rheumatology (Oxford) 2019 Mar 11. Epub 2019 Mar 11.

Arthritis Center Twente, Department of Psychology, Health and Technology, University of Twente.

Objective: Inflammation-related symptoms such as pain, swelling and tenderness of the affected joint are frequently assessed using 5-point diary rating scales in gout clinical trials. Combining these into a single gout attack symptom intensity score may be a useful summary measure for these data, which is potentially more responsive to change compared with the individual components. The objective of this study was to develop a patient-reported gout flare intensity score, the Gout Attack Intensity Score (GAIS), for use in clinical studies, that includes components for gout-related pain, swelling and tenderness. Read More

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http://dx.doi.org/10.1093/rheumatology/kez064DOI Listing
March 2019
1 Read