7,892 results match your criteria Rheumatology Oxford [Journal]


Genetics and epigenetics in primary Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Primary Sjögren's syndrome (pSS) is considered to be a multifactorial disease, where underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to disease development. In the last 5 years, the first genome-wide association studies in pSS have been completed. The strongest signal of association lies within the HLA genes, whereas the non-HLA genes IRF5 and STAT4 show consistent associations in multiple ethnicities but with a smaller effect size. Read More

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http://dx.doi.org/10.1093/rheumatology/key330DOI Listing
February 2019

T cells in primary Sjögren's syndrome: targets for early intervention.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

A histologic hallmark of primary SS (pSS) is lymphocytic infiltration of the salivary and lacrimal glands, in particular by CD4+ T and B cells. In the early stages of the disease, infiltrates are dominated by CD4+ T cells, while B cell accumulation occurs at later stages. Activated T cells contribute to pathogenesis by producing pro-inflammatory cytokines and by inducing B cell activation, which results in the establishment of a positive feedback loop. Read More

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http://dx.doi.org/10.1093/rheumatology/kez004DOI Listing
February 2019

Synovial fluid leukocyte count in asymptomatic hyperuricaemia with crystal deposition: a proof-of-concept study.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Sección de Reumatología, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario de Alicante, Spain.

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http://dx.doi.org/10.1093/rheumatology/kez023DOI Listing
February 2019

Health-related quality of life and costs in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.

Health-related quality of life (HRQoL) has an increasing role in medical decision-making. This review of the literature aims to provide an overview on HRQoL, costs, and work disability in SS, a disease characterized by focal lymphocytic infiltration of exocrine glands with no therapeutics of proven immunomodulatory potential. HRQoL is markedly reduced in SS in multiple studies across many countries when compared with HRQoL in healthy controls. Read More

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http://dx.doi.org/10.1093/rheumatology/key370DOI Listing
February 2019

How to treat Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

SS is a chronic, autoimmune disease of unknown aetiology for which there is no known curative treatment. Although dryness of the eyes and mouth are the classically described features, patients often experience drying of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia. There is an association with other autoimmune diseases, especially thyroid disease, coeliac disease and primary biliary cholangitis. Read More

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http://dx.doi.org/10.1093/rheumatology/key363DOI Listing
February 2019

B cells in Sjögren's syndrome: from pathophysiology to therapeutic target.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, Inserm, France.

Biological abnormalities associated with B lymphocytes are a hallmark of patients with primary Sjögren's syndrome. Those patients present abnormal distribution of B lymphocytes in peripheral blood and B cells in exocrine glands. B cells produce auto-antibodies, cytokines and present antigens but can also suppressive functions. Read More

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http://dx.doi.org/10.1093/rheumatology/key332DOI Listing
February 2019

Lysyl oxidase-a possible role in systemic sclerosis-associated pulmonary hypertension: a multicentre study.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Unit, Bnai-Zion Medical Center, Haifa, Israel.

Objective: Lysyl oxidase (LOX) is an extracellular enzyme that cross-links collagen fibrils. LOX was found to be increased in serum of SSc patients and was suggested to be related to skin fibrosis, yet a vascular source of LOX has been demonstrated in idiopathic pulmonary arterial hypertension (iPAH). We aimed to validate elevated LOX serum levels in SSc and to study its correlation with clinical characteristics and investigate its main source at the tissue level. Read More

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http://dx.doi.org/10.1093/rheumatology/kez035DOI Listing
February 2019
1 Read

Comorbidities (excluding lymphoma) in Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Gran Canaria, Spain.

The information about comorbidities (excluding lymphoma) in primary Sjögren's syndrome (pSS) is relatively scarce. Cardiovascular disease, infections, musculoskeletal conditions or malignancy are likely the most relevant comorbid conditions in pSS. Different infections (particularly oral candidal infections) and fibromyalgia are extremely frequent in the daily clinical practice. Read More

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http://dx.doi.org/10.1093/rheumatology/key329DOI Listing
February 2019

Innate immunity and interferons in the pathogenesis of Sjögren's syndrome.

Rheumatology (Oxford) 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Primary SS (pSS) is a rheumatic disease characterized by an immune-mediated exocrinopathy, resulting in severe dryness of eyes and mouth. Systemic symptoms include fatigue and joint pain and a subset of patients develop more severe disease with multi-organ involvement. Accumulating evidence points to involvement of innate immunity and aberrant activity of the type I IFN system in both the initiation and propagation of this disease. Read More

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http://dx.doi.org/10.1093/rheumatology/key360DOI Listing
February 2019

Reversible eruption of neurofibromatosis associated with tofacitinib therapy for rheumatoid arthritis.

Rheumatology (Oxford) 2019 Feb 7. Epub 2019 Feb 7.

Department of Rheumatology, Western Health, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1093/rheumatology/kez012DOI Listing
February 2019
1 Read

Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients.

Rheumatology (Oxford) 2019 Feb 8. Epub 2019 Feb 8.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

Objective: The diagnostic value added by musculoskeletal ultrasound (MSUS) over standard clinical and laboratory parameters has proved difficult to quantify. The additive contribution to diagnostic classification of a pragmatic, 15 min MSUS protocol was appraised in a large, unselected cohort of early arthritis clinic attendees.

Methods: Detailed baseline characteristics were recorded. Read More

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http://dx.doi.org/10.1093/rheumatology/kez008DOI Listing
February 2019

EULAR President-Elect awarded CBE by Her Majesty the Queen Elizabeth II.

Authors:

Rheumatology (Oxford) 2019 Feb 11. Epub 2019 Feb 11.

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http://dx.doi.org/10.1093/rheumatology/kez024DOI Listing
February 2019

Use of combined hormonal contraceptives among women with systemic lupus erythematosus with and without medical contraindications to oestrogen.

Rheumatology (Oxford) 2019 Feb 8. Epub 2019 Feb 8.

Division of Rheumatology, McGill University Health Centre, Montreal, Quebec, Canada.

Objectives: To assess the prevalence of combined hormonal contraceptives (CHCs) in reproductive-age women with SLE with and without possible contraindications and to determine factors associated with their use in the presence of possible contraindications.

Methods: This observational cohort study included premenopausal women ages 18-45 years enrolled in the SLICC Registry ⩽15 months after SLE onset, with annual assessments spanning 2000-2017. World Health Organization Category 3 or 4 contraindications to CHCs (e. Read More

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http://dx.doi.org/10.1093/rheumatology/kez014DOI Listing
February 2019
2 Reads

Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis.

Rheumatology (Oxford) 2019 Feb 8. Epub 2019 Feb 8.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

Objectives: Dysregulated signal transduction and activator of transcription-3 (STAT3) signalling in CD4+ T cells has been proposed as an early pathophysiological event in RA. We sought further evidence for this observation, and to determine its clinical relevance.

Methods: Microarray technology was used to measure gene expression in purified peripheral blood CD4+ T cells from treatment-naïve RA patients and disease controls newly recruited from an early arthritis clinic. Read More

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http://dx.doi.org/10.1093/rheumatology/kez003DOI Listing
February 2019
1 Read

Screening for two or three autoantibodies in persons at risk for RA: implications of current data for clinical practice.

Rheumatology (Oxford) 2019 Feb 6. Epub 2019 Feb 6.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/key441DOI Listing
February 2019

Second autologous haematopoietic stem cell transplantation in systemic sclerosis-a case report.

Rheumatology (Oxford) 2019 Feb 8. Epub 2019 Feb 8.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kez010DOI Listing
February 2019
1 Read

Has TNF inhibitor use decreased the need for total hip and total knee replacement for patients with RA?

Rheumatology (Oxford) 2019 Feb 6. Epub 2019 Feb 6.

Weill Cornell Medical School, Hospital for Special Surgery, New York City, NY, USA.

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http://dx.doi.org/10.1093/rheumatology/kez022DOI Listing
February 2019

Combining immunofluorescence with immunoblot assay improves the specificity of autoantibody testing for myositis.

Rheumatology (Oxford) 2019 Feb 4. Epub 2019 Feb 4.

Laboratorio di Patologia Clinica, Ospedale San Antonio, Tolmezzo, Italy.

Objective: Immunoblot (IB) methods are widely used to detect myositis-specific autoantibodies (MSAs); however, false-positive results are common. In this study, we aimed to determine whether associating the anti-nuclear antibody (ANA) IIF pattern may help to improve the specificity of MSA detection by IB in patients with idiopathic inflammatory myositis (IIM).

Methods: Serum samples from 104 patients presenting with muscle weakness/myalgia and positive to at least one MSA by IB (MYOS12 Diver and MIOS7 Diver, D-tek) were tested for ANAs on HEp-2000 cells (Immuno Concepts). Read More

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http://dx.doi.org/10.1093/rheumatology/key451DOI Listing
February 2019

AbbVie and J&J dominate clinical trial development in psoriatic arthritis, says GlobalData.

Authors:

Rheumatology (Oxford) 2019 Feb 5. Epub 2019 Feb 5.

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http://dx.doi.org/10.1093/rheumatology/kez019DOI Listing
February 2019
1 Read

Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II).

Rheumatology (Oxford) 2019 Feb 4. Epub 2019 Feb 4.

Academic Rheumatology, University of Nottingham, Nottingham, UK.

Objectives: To examine the predictive validity of the Gout Activity Score (GAS), its correlation with the Gout Impact Scale (GIS) and their sensitivity to change.

Methods: Data from a clinical trial in which participants with one or more gout flares in the previous year were recruited from primary care and randomized to nurse-led or continuing usual care were used in this study. GAS and GIS were calculated as described, with higher scores indicating worse disease activity and quality of life, respectively. Read More

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http://dx.doi.org/10.1093/rheumatology/key446DOI Listing
February 2019
1 Read

Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin's lymphoma: a nationwide population-based study.

Rheumatology (Oxford) 2019 Feb 4. Epub 2019 Feb 4.

Institute of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

Objectives: We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin's lymphoma (NHL).

Methods: Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998-2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population. Read More

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http://dx.doi.org/10.1093/rheumatology/kez011DOI Listing
February 2019
4 Reads

Giant thoracic calcinosis: a dermatomyositis manifestation.

Rheumatology (Oxford) 2019 Jan 30. Epub 2019 Jan 30.

Unit of Autoimmune Disease, San Cecilio University Hospital, Granada, Spain.

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http://dx.doi.org/10.1093/rheumatology/kez013DOI Listing
January 2019
3 Reads

Monogenic mimics of Behçet's disease in the young.

Rheumatology (Oxford) 2019 Jan 30. Epub 2019 Jan 30.

Infection, Inflammation and Rheumatology Section, UCL Great Ormond Street Institute of Child Health, London, UK.

Objectives: Monogenic autoinflammatory disorders (AID) and primary immunodeficiencies can present early in life with features that may be mistaken for Behçet's disease (BD). We aimed to retrospectively describe the clinical and laboratory features of 11 paediatric cases referred for suspected BD who turned out to have an alternative, monogenic disease mimicking BD.

Methods: Retrospective, paediatric BD specialist multicentre case series. Read More

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http://dx.doi.org/10.1093/rheumatology/key445DOI Listing
January 2019
1 Read

Structural efficacy of NSAIDs, COX-2 inhibitor and glucocorticoid compared with TNFα blocker: a study in adjuvant-induced arthritis rats.

Rheumatology (Oxford) 2019 Feb 1. Epub 2019 Feb 1.

EA 4267 «PEPITE», UFR Santé, Franche-Comté University, 19 rue Ambroise Paré, bâtiment S, BESANCON cedex, France.

Objective: To evaluate radiographic outcomes after an early treatment for 21 days with etanercept, naproxen, celecoxib, prednisone or methotrexate in adjuvant-induced arthritis in rats.

Methods: At the onset of arthritis, rats were daily treated with naproxen (10 mg/kg/day i.p. Read More

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http://dx.doi.org/10.1093/rheumatology/key444DOI Listing
February 2019
1 Read

Glossopharyngeal/vagus nerve disorder due to IgG4-related hypertrophic pachymeningitis.

Rheumatology (Oxford) 2019 Jan 30. Epub 2019 Jan 30.

Department of Internal Medicine, Tomakomai City Hospital, Tomakomai, Japan.

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http://dx.doi.org/10.1093/rheumatology/kez009DOI Listing
January 2019

Clinical significance of Janus Kinase inhibitor selectivity.

Authors:
Ernest H Choy

Rheumatology (Oxford) 2019 Jan 28. Epub 2019 Jan 28.

CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.

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http://dx.doi.org/10.1093/rheumatology/kez002DOI Listing
January 2019

Atrophic palmar papules in lupus erythematosus: are inverse Gottron papules specific for dermatomyositis?

Rheumatology (Oxford) 2019 Feb;58(2):370

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/key247DOI Listing
February 2019
1 Read

Efficacy and safety of rituximab in anti-synthetase antibody positive and negative subjects with idiopathic inflammatory myopathy: a registry-based study.

Rheumatology (Oxford) 2019 Jan 25. Epub 2019 Jan 25.

Division of Rheumatology, Department of Medicine, Solna, and Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

Objective: Post-hoc analyses of the Rituximab in Myositis trial indicate that specific autoantibodies profiles may influence treatment response. We compared the efficacy and safety of rituximab in anti-synthetase antibody (ARS-ab) positive and negative patients.

Methods: Adult idiopathic inflammatory myopathy (IIM) subjects in the Swedish Rheumatology Quality Register who received ⩾ 1 cycle of rituximab were enrolled. Read More

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http://dx.doi.org/10.1093/rheumatology/key450DOI Listing
January 2019

Tissue inflammation signatures point towards resolution in adhesive capsulitis.

Rheumatology (Oxford) 2019 Jan 27. Epub 2019 Jan 27.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/rheumatology/kez007DOI Listing
January 2019
1 Read

Kikuchi-Fujimoto disease with relapsing polychondritis.

Rheumatology (Oxford) 2019 Jan 28. Epub 2019 Jan 28.

Department of Internal Medicine (Rheumatology Unit), Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/key449DOI Listing
January 2019
1 Read
4.475 Impact Factor

Prognostic properties of anti-topoisomerase antibodies in patients identified by the ACR/EULAR 2013 systemic sclerosis criteria.

Rheumatology (Oxford) 2019 Jan 27. Epub 2019 Jan 27.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kez005DOI Listing
January 2019

Vedolizumab for inflammatory bowel disease: a two-edge sword in the gut-joint/enthesis axis.

Rheumatology (Oxford) 2019 Jan 28. Epub 2019 Jan 28.

Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1093/rheumatology/key440DOI Listing
January 2019

Development and validation of a composite disease activity score for measurement of muscle and skin involvement in juvenile dermatomyositis.

Rheumatology (Oxford) 2019 Jan 23. Epub 2019 Jan 23.

Dipartimento di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno-Infantili, Università degli Studi di Genova, Genoa, Italy.

Objective: To develop a composite DAS for JDM and provide preliminary evidence of its validity.

Methods: The Juvenile DermatoMyositis Activity Index (JDMAI) is composed of four items: physician's global assessment of overall disease activity; parent's/child's global assessment of child's wellbeing; measurement of muscle strength; and assessment of skin disease activity. The score of the JDMAI is the arithmetic sum of the scores of each individual component. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key421DOI Listing
January 2019
3 Reads

Incidental significant arrhythmia in scleroderma associates with cardiac magnetic resonance measure of fibrosis and hs-TnI and NT-proBNP.

Rheumatology (Oxford) 2019 Jan 28. Epub 2019 Jan 28.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK.

Objectives: To screen for significant arrhythmias with an implantable loop recorder (ILR) in patients with SSc and no known cardiovascular disease, and identify associated disease phenotype, blood and cardiovascular magnetic resonance (CMR) biomarkers.

Methods: Twenty patients with SSc with no history of primary SSc heart disease, traditional cardiovascular disease, diabetes or maximum one traditional cardiovascular risk factor underwent clinical assessment, contrast-enhanced CMR and ILR insertion.

Results: ILR data were available for 19 patients: 63% female, mean (s. Read More

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http://dx.doi.org/10.1093/rheumatology/key430DOI Listing
January 2019
2 Reads

Prevalence and distribution of cartilage damage at the metacarpal head level in rheumatoid arthritis and osteoarthritis: an ultrasound study.

Rheumatology (Oxford) 2019 Jan 25. Epub 2019 Jan 25.

Rheumatology Department, Università Politecnica delle Marche, C. Urbani Hospital, Jesi, Ancona, Italy.

Objectives: To determine the prevalence and distribution of US-detected qualitative cartilage damage at metacarpal heads of patients with RA and hand OA.

Methods: Fifty-two RA patients and 34 patients with hand OA were enrolled. US examination of the metacarpal head cartilage from the II to V finger of both hands was performed. Read More

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http://dx.doi.org/10.1093/rheumatology/key443DOI Listing
January 2019
4.475 Impact Factor

Most needle-shaped calcium pyrophosphate crystals lack birefringence.

Rheumatology (Oxford) 2019 Jan 25. Epub 2019 Jan 25.

Departamento Medicina Clínica, Universidad Miguel Hernández de Elche, Alicante, Spain.

Objectives: CPP crystals can be polymorphic (rhomboidal, parallelepiped: R/P), but some look like needles and could be taken as MSU under the bright field microscope. Birefringence of CPP crystals is weaker or absent compared with MSU crystals, but we aim to evaluate whether the grade of birefringence varies regarding the shape of the CPP crystal.

Methods: SF samples from patients with demonstrated acute CPP crystal arthritis were analysed by two observers, using a simple polarized light microscope equipped with two viewing stations. Read More

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http://dx.doi.org/10.1093/rheumatology/key442DOI Listing
January 2019

The European network for care of children with paediatric rheumatic diseases: care across borders.

Rheumatology (Oxford) 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatric Immunology and Rheumatology, Wilhelmina Kinderziekenhuis, University Medical Center Utrecht, Utrecht, Netherlands.

Objectives: To provide an overview of the paediatric rheumatology (PR) services in Europe, describe current delivery of care and training, set standards for care, identify unmet needs and inform future specialist service provision.

Methods: An online survey was developed and presented to national coordinating centres of the Paediatric Rheumatology International Trials Organisation (PRINTO) (country survey) and to individual PR centres (centre and disease surveys) as a part of the European Union (EU) Single Hub and Access point for paediatric Rheumatology in Europe project. The survey contained components covering the organization of PR care, composition of teams, education, health care and research facilities and assessment of needs. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key439DOI Listing
January 2019
4 Reads

Comparative effectiveness of abatacept, rituximab, tocilizumab and TNFi biologics in RA: results from the nationwide Swedish register.

Rheumatology (Oxford) 2019 Jan 21. Epub 2019 Jan 21.

Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm.

Objectives: Current guidelines rank abatacept, rituximab, tocilizumab and TNF-inhibitors (TNFi) as having equal effectiveness for the treatment of RA, at least as second line therapies. These recommendations are mainly based on meta-analysis of randomized controlled trials, with few direct drug-drug comparisons. Our objective was to compare the real-world absolute and relative effectiveness among RA patients starting any of the available biologic DMARDs (bDMARDs). Read More

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http://dx.doi.org/10.1093/rheumatology/key433DOI Listing
January 2019
4 Reads

A patient with a mediatinal mass and diffuse asymptomatic osteolytic lesions.

Rheumatology (Oxford) 2019 Jan 10. Epub 2019 Jan 10.

Rheumatology Service at Hospital Nossa Senhora da Conceição.

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http://dx.doi.org/10.1093/rheumatology/key381DOI Listing
January 2019
1 Read

Performance of referral strategies for spondyloarthritis: a population-based nationwide study.

Rheumatology (Oxford) 2019 Jan 14. Epub 2019 Jan 14.

NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal.

Objectives: To evaluate the performance of the referral strategy (RS) for SpA of a nationwide epidemiological study (EpiReumaPt), as compared with previously proposed RSs.

Methods: EpiReumaPt was a three-stage national epidemiologic study. In phase one, 10 661 adult participants were randomly selected and screened for rheumatic and musculoskeletal diseases. Read More

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http://dx.doi.org/10.1093/rheumatology/key436DOI Listing
January 2019
2 Reads
4.475 Impact Factor

Synovial fluid fetuin-A levels in patients affected by osteoarthritis with or without evidence of calcium crystals.

Rheumatology (Oxford) 2019 Jan 10. Epub 2019 Jan 10.

Rheumatology Unit, Department of Medicine - DIMED, University Hospital of Padova.

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http://dx.doi.org/10.1093/rheumatology/key435DOI Listing
January 2019
2 Reads

Effects of concomitant glucocorticoids in TOZURA, a common-framework study programme of subcutaneous tocilizumab in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Jan 10. Epub 2019 Jan 10.

F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Objectives: This post hoc analysis of the TOZURA study programme evaluated the efficacy and safety of subcutaneous tocilizumab (TCZ-SC) as monotherapy or with concomitant conventional synthetic DMARDs (csDMARDs) in patients with RA categorized by baseline glucocorticoid (GC) use.

Methods: TOZURA was a multinational, open-label, single-arm, common-framework study programme (11 protocols, 22 countries) in patients with moderate to severe RA in whom csDMARDs or biologic therapies had failed or who were MTX naïve. Patients received once-weekly TCZ-SC 162 mg for ⩾24 weeks as monotherapy or in combination with csDMARDs and/or oral GC use (⩽10 mg/day prednisone or equivalent), which was to be continued unchanged for 24 weeks. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key393DOI Listing
January 2019
5 Reads

Impact of TNF inhibitor therapy on joint replacement rates in rheumatoid arthritis: a matched cohort analysis of BSRBR-RA UK registry data.

Rheumatology (Oxford) 2019 Jan 10. Epub 2019 Jan 10.

Pharmaco- and Device-Epidemiology Group, Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford.

Objectives: Previous ecological data suggest a decline in the need for joint replacements in RA patients following the introduction of TNF inhibitor (TNFi) therapy, although patient-level data are lacking. Our primary aim was to estimate the association between TNFi use and subsequent incidence of total hip replacement (THR) and total knee replacement.

Methods: A propensity score matched cohort was analysed using the British Society for Rheumatology Biologics Registry (2001-2016) for RA data. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key424DOI Listing
January 2019
5 Reads

Elevated faecal calprotectin is linked to worse disease status in axial spondyloarthritis: results from the SPARTAKUS cohort.

Rheumatology (Oxford) 2019 Jan 15. Epub 2019 Jan 15.

Department of Clinical Sciences Lund, Rheumatology, Lund University.

Objectives: To examine faecal calprotectin (F-calprotectin) levels and presence of anti-Saccharomyces cerevisiae antibodies (ASCA) and their associations with disease subtype and current status in axial SpA (axSpA).

Methods: F-calprotectin and ASCA in serum were compared between consecutive patients with a clinical axSpA diagnosis, classified as non-radiographic axSpA (nr-axSpA; n = 40) or AS (n = 90), and with healthy controls (n = 35). Furthermore, standard axSpA outcome measures were compared between axSpA patients (nr-axSpA and AS combined) with elevated vs normal F-calprotectin, ASCA IgA and IgG, respectively. Read More

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http://dx.doi.org/10.1093/rheumatology/key427DOI Listing
January 2019
1 Read
4.475 Impact Factor

Polymyalgia rheumatica with normal values of both erythrocyte sedimentation rate and C-reactive protein concentration at the time of diagnosis.

Rheumatology (Oxford) 2019 Jan 10. Epub 2019 Jan 10.

Department of Rheumatology, Internal Medicine & Geriatrics, Pomeranian Medical University, Szczecin, Poland.

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http://dx.doi.org/10.1093/rheumatology/key431DOI Listing
January 2019
4 Reads

Comment on: A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.

Rheumatology (Oxford) 2019 Jan 15. Epub 2019 Jan 15.

Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/key403DOI Listing
January 2019
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Circulating CD24hiCD38hi regulatory B cells correlate inversely with the ThEM17 cell frequency in granulomatosis with polyangiitis patients.

Rheumatology (Oxford) 2019 Jan 10. Epub 2019 Jan 10.

Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Objectives: To investigate whether there is a direct relation between expanded proportions of Th17 effector memory (ThEM17) cells and regulatory B cells (Bregs) in peripheral blood of granulomatosis with polyangiitis (GPA) patients.

Methods: Frequencies of Bregs and ThEM17 cells, as well as ThEM1 cells, were determined by flow cytometry in blood samples from 42 GPA patients in remission and 18 matched healthy controls (HCs). The Breg frequency was defined as CD24hiCD38hiCD19+ cells. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key412DOI Listing
January 2019
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