104,388 results match your criteria Rheumatology Oxford [Journal]


[Interlocking femoral nail and total knee Arthroplasty in one stage for a patient with a femoral diaphyseal stress fracture].

Acta Ortop Mex 2018 May-Jun;32(3):163-166

Servicio de Cirugía Ortopédica y Traumatología, Hospital de Sabadell. Institut Universitari Parc Taulí Universitat Autònoma de Barcelona, España.

We present the case of an 81-year-old woman who was followed up by the Rheumatology Service for osteoporosis and treated with bisphosphonates for more than five years. She reported a fracture of the distal third of the contralateral femur by a low energy mechanism, treated with retrograde intramedullary nailing the previous year. She presented a clinic of cruralgia and left gonalgia, without previous trauma. Read More

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December 2018

The Added Value of a Vasculitis Clinic in a Tertiary Referral Hospital.

Acta Med Port 2018 Nov 30;31(11):614-617. Epub 2018 Nov 30.

Rheumatology Department. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisbon Academic Medical Centre. Lisbon. Portugal.

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November 2018
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Diffuse Tibiofemoral Cartilage Change Prior to the Development of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA.

Introduction: We compared the spatial distribution of tibiofemoral cartilage change between individuals who will develop accelerated knee osteoarthritis (KOA) versus typical onset of KOA prior to the development of radiographic KOA.

Materials And Methods: We conducted a longitudinal case-control analysis of 129 individuals from the Osteoarthritis Initiative. We assessed the percent change in tibiofemoral cartilage on magnetic resonance images at 36 informative locations from two to one year prior to the development of accelerated (n=44) versus typical KOA (n=40). Read More

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December 2018

Coexistence of systemic lupus erythematosus with Kikuchi-Fujimoto disease involving the salivary gland, initially disguised as lymphoma.

Rheumatology (Oxford) 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Department of Internal Medicine, Jeonju, Republic of Korea.

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December 2018

Antiphospholipid score is a novel risk factor for idiopathic osteonecrosis of the femoral head in patients with systemic lupus erythematosus.

Rheumatology (Oxford) 2018 Dec 6. Epub 2018 Dec 6.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objectives: Idiopathic osteonecrosis of the femoral head (ION) is a common complication of SLE associated with CS therapy. Although the pathogenesis of ION involves local bone ischaemia favoured by thrombophilia, the involvement of aPL in lupus ION remains to be elucidated. We have previously reported the aPL score (aPL-S) as a quantitative marker of aPL and the development of thrombotic events in autoimmune diseases. Read More

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December 2018

Successful Methotrexate Treatment of Chronic Chikungunya Arthritis.

J Clin Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Section of Rheumatology, Yale University School of Medicine, New Haven, CT.

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December 2018

Rheumatoid Arthritis and Mortality in End Stage Renal Disease.

J Clin Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine, Division of Rheumatology and Adult Allergy, Medical College of Georgia at Augusta University, Augusta, GA.

Objective: To determine whether rheumatoid arthritis (RA) is a risk factor for cardiovascular disease (CVD) events, all-cause mortality and cardiovascular mortality in End Stage Renal Disease (ESRD).

Methods: Cohort study of adult patients with ESRD in the United States Renal Data System (USRDS) with RA and a 5% random sample of those without RA. CVD events, all-cause mortality and cardiovascular mortality were determined in those with RA compared to those without RA using Cox Proportional Hazards modeling. Read More

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December 2018

Giant Cell Arteritis Presenting as an Ischaemic Upper Limb

Ir Med J 2018 08 13;111(7):791. Epub 2018 Aug 13.

Department of Rheumatology, Mercy University Hospital, Cork, Ireland

Aim To present an interesting case of giant cell arteritis presenting as ischaemic upper limb. Methods Data was collected from the patient’s chart and from radiology and laboratory systems in our institution. Results The patient had a temporal artery biopsy confirming the diagnosis of temporal arteritis. Read More

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Knowledge and practice in the management of asymptomatic hyperuricemia among primary health care physicians in Jeddah, Western Region of Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1218-1225

Joint Program of Family Medicine, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess knowledge and practice levels in asymptomatic hyperuricemia (AH) and investigate predictors of urate-lowering therapy (ULT) misprescribing among primary health care (PHC) physicians.

Methods: A cross-sectional study was conducted among 201 PHC physicians from December 2017 to May 2018. A based clinical guidelines for hyperuricemia management from American Professional Organizations, a semi-structured questionnaire was administered to collect demographic and professional data; knowledge and practice levels in management of AH; and barriers to the management of hyperuricemia and gout, with focus of the misprescribing of ULT in AH. Read More

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December 2018

Targeted Feature Extraction in MALDI Mass Spectrometry Imaging to Discriminate Proteomic Profiles of Breast and Ovarian Cancer.

Proteomics Clin Appl 2018 Dec 6:e1700168. Epub 2018 Dec 6.

University of Bremen, Bremen, Germany.

Purpose: To develop a mass spectrometry imaging (MSI) based workflow for extracting m/z values related to putative protein biomarkers and using these for reliable tumor classification.

Experimental Design: Given a list of putative breast and ovarian cancer biomarker proteins, we extracted a set of related m/z values from heterogeneous MSI datasets derived from formalin-fixed paraffin-embedded tissue material. Based on these features, a linear discriminant analysis classification model was trained to discriminate the two tumor types. Read More

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December 2018

Central PRES (posterior reversible encephalopathy syndrome) in HELLP syndrome.

Intern Emerg Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Neuroradiology, Erasme Hospital, University of Brussels (ULB), Route de Lennik 808, 1070, Brussels, Belgium.

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December 2018

Dendritic cells in the pathogenesis of ankylosing spondylitis and axial spondyloarthritis.

Clin Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

The interaction of dendritic cells (DCs) with the human microbiome, with distorted handling of the microbiota or its products via the direct effect of HLA B27, probably represents the initial element in the chain of events leading to the development of clinical axial spondyloarthritis. The mechanism of disease extension onto the skeleton and other tissues involved, such as uvea, may also involve migratory DCs. Finally, the role of DCs in the initiation of the inflammatory tissue response with activation of the IL-17 axis has been demonstrated. Read More

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December 2018
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Vertebral fractures cascade: potential causes and risk factors.

Osteoporos Int 2018 Dec 5. Epub 2018 Dec 5.

Rheumatology Department, INSERM 1153, CHU Paris Cochin, Paris Descartes University, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France.

We performed a study to identify potential causes and risk factors of vertebral fracture cascade. Vertebral fracture cascade is a severe clinical event in patients with bone fragility. Only half of patients have an identified cause of secondary osteoporosis. Read More

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December 2018

Safety of statin drugs in patients with dyslipidemia and stable systemic autoimmune myopathies.

Rheumatol Int 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Recent studies have shown a high prevalence of dyslipidemia in patients with systemic autoimmune myopathies (SAM). However, little is known about the safety of the use of statins in these patients, and this gap in research motivated the accomplishment of the present study. In a retrospective cohort study conducted from 2004 to 2018, 250 patients with SAM were evaluated, and 24 patients had stable forms of SAM (16 dermatomyositis, 1 polymyositis and 7 antisynthetase syndrome) but had dyslipidemia and had received statins. Read More

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December 2018

Should We Always Use Antibiotics after Urodynamic Studies in High-Risk Patients?

Biomed Res Int 2018 5;2018:1607425. Epub 2018 Nov 5.

2nd Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

Aim: The aim of this observational study was to evaluate the effectiveness of a phytotherapic drug (Canephron N) in preventing urinary tract infection (UTI) in high-risk women undergoing urodynamic studies (UDS).

Methods: The study protocol was approved by the local institutional ethical committee. Adult women with at least one risk factor for acquiring UTI (defined as: age over 70, elevated postvoid residual urine>100 ml, recurrent UTI, pelvic organ prolapse (POP) ≥II in POP-Q scale, and neurogenic bladder) had received after UDS either a single oral dose of fosfomycin trometamol (FT) (3 grams) or a phytodrug containing centaury herb, lovage root, and rosemary leaves (5 ml taken orally three times daily for one week). Read More

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November 2018
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Assessment of survival in patients with idiopathic pulmonary fibrosis using quantitative HRCT indexes.

Multidiscip Respir Med 2018 1;13:43. Epub 2018 Dec 1.

1Regional Referral Centre for Rare Lung Diseases, A.O.U. Policlinico-Vittorio Emanuele, Department of Clinical and Experimental Medicine, University of Catania, via Santa Sofia 78, Catania, Italy.

Background: The assessment of Idiopathic Pulmonary Fibrosis (IPF) using HRCT requires great experience and is limited by a significant inter-observer variability, even between trained radiologists. The evaluation of HRCT through automated quantitative analysis may hopefully solve this problem. The accuracy of CT-histogram derived indexes in the assessment of survival in IPF patients has been poorly studied. Read More

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December 2018

Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study.

Pharmgenomics Pers Med 2018 12;11:205-210. Epub 2018 Nov 12.

Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, SA, Australia.

Purpose: Methotrexate (MTX) treatment is associated with lower blood pressure (BP) and arterial stiffness in rheumatoid arthritis (RA). We investigated associations between single-nucleotide polymorphism (SNP) of the ATP-binding cassette efflux transporter gene (rs2231142), BP, and arterial stiffness in RA patients treated with MTX.

Patients And Methods: Clinical and 24-hour peripheral and central BP, arterial wave reflection (Augmentation Index, AIx), arterial stiffness (Pulse Wave Velocity, PWV), and intracellular MTX polyglutamate (MTXPGs) concentrations were assessed in 56 RA patients on stable treatment with MTX using a repeated cross-sectional study design with measurements at baseline and after 8 months. Read More

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November 2018
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Analysis of drug utilization and health care resource consumption in patients with psoriasis and psoriatic arthritis before and after treatment with biological therapies.

Biologics 2018 12;12:151-158. Epub 2018 Nov 12.

Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.

Objectives: To describe the therapeutic pathways of patients with psoriasis (PSO) and psoriatic arthritis (PsA) before and after treatment with biological therapies in a real-world setting and to determine the relative consumption of health care resources.

Design: Retrospective observational study.

Setting: Real-life clinical setting in 5 Italian local health units. Read More

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November 2018

Publisher Correction: A Pilot Study on Tocilizumab for Treating Refractory Adult-Onset Still's Disease.

Sci Rep 2018 Dec 5;8(1):17751. Epub 2018 Dec 5.

Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200001, China.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. Read More

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December 2018

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis.

Cell Death Dis 2018 Dec 5;9(12):1166. Epub 2018 Dec 5.

CellCOM research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), Xubias de Arriba, 84, 15006 A, Coruña, Spain.

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. Similar to other wound-healing disorders, chondrocytes from OA patients show a chronic increase in the gap junction channel protein connexin43 (Cx43), which regulates signal transduction through the exchange of elements or recruitment/release of signalling factors. Read More

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December 2018

Cell-based immunotherapy approaches for multiple myeloma.

Br J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Hematology, Oncology and Rheumatology, Heidelberg University, Heidelberg, Germany.

Despite the arrival of novel therapies, multiple myeloma (MM) remains incurable and new treatment options are needed. Chimeric antigen receptor (CAR) T cells are genetically modified T cells that express a CAR directed against specific tumour antigens. CAR T cells are able to kill target tumour cells and may result in long-lasting immune responses in vivo. Read More

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December 2018

Ultrasound thresholds for synovial abnormalities.

Authors:
Joanna Collison

Nat Rev Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Rheumatology, .

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December 2018

Low-dose IL-2 therapy for autoimmune diseases.

Authors:
Joanna Collison

Nat Rev Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Rheumatology, .

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December 2018

Tender joints might not indicate inflammation.

Authors:
Joanna Collison

Nat Rev Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Nature Reviews Rheumatology, .

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December 2018

CD19+IgM+ cells demonstrate enhanced therapeutic efficacy in type 1 diabetes mellitus.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism Department of Medicine, and.

We describe a protective effect on autoimmune diabetes and reduced destructive insulitis in NOD.scid recipients following splenocyte injections from diabetic NOD donors and sorted CD19+ cells compared with NOD.scid recipients receiving splenocytes alone. Read More

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December 2018

Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Molecular Rheumatology, School of Medicine, Trinity College Dublin, Ireland.

CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanistic studies in autoimmune disease are limited. This is the first study to our knowledge examining CD141+ DC in autoimmune disease, specifically inflammatory arthritis (IA). Read More

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December 2018

Hemagglutinin stalk-reactive antibodies interfere with influenza virus neuraminidase activity by steric hindrance.

J Virol 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA.

Hemagglutinin (HA) stalk-reactive antibodies are the basis of several current "one-shot" universal influenza vaccine efforts because they protect against a wide spectrum of influenza virus strains. The appreciated mechanism of protection by HA-stalk antibodies is to inhibit HA stalk reconfiguration, blocking viral fusion and entry. This study shows that HA stalk-reactive antibodies also inhibit neuraminidase (NA) enzymatic activity, prohibiting viral egress. Read More

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December 2018

Cumulative network-meta-analyses, practice guidelines and actual prescriptions of drug treatments for postmenopausal osteoporosis: a study protocol for cumulative network meta-analyses and meta-epidemiological study.

BMJ Open 2018 Dec 4;8(12):e023218. Epub 2018 Dec 4.

Department of Health Promotion and Human Behavior, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: Cumulative network meta-analysis (NMA) is a method to provide a global comparison of multiple treatments with real-time update to evidence users. Several studies investigated the ranking of cumulative NMA and the recommendations of practice guidelines. However, to the best of our knowledge, no study has evaluated the cumulative NMA ranking and prescription patterns. Read More

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December 2018
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Siglec-1 Macrophages and the Contribution of IFN to the Development of Autoimmune Congenital Heart Block.

J Immunol 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016.

Given that diseases associated with anti-SSA/Ro autoantibodies, such as systemic lupus erythematosus and Sjögren syndrome, are linked with an upregulation of IFN and type I IFN-stimulated genes, including sialic acid-binding Ig-like lectin 1 (Siglec-1), a receptor on monocytes/macrophages, recent attention has focused on a potential role for IFN and IFN-stimulated genes in the pathogenesis of congenital heart block (CHB). Accordingly, three approaches were leveraged to address the association of IFN, IFN-stimulated genes, and the phenotype of macrophages in affected fetal cardiac tissue: 1) cultured healthy human macrophages transfected with hY3, an anti-SSA/Ro-associated ssRNA, 2) RNA isolated from freshly sorted human leukocytes/macrophages after Langendorff perfusion of three fetal hearts dying with CHB and three healthy gestational age-matched hearts, and 3) autopsy tissue from three additional human CHB hearts and one healthy heart. TLR ligation of macrophages with hY3 led to the upregulation of a panel of IFN transcripts, including SIGLEC1, a result corroborated using quantitative PCR. Read More

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December 2018

Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.

Arthritis Res Ther 2018 Dec 5;20(1):268. Epub 2018 Dec 5.

Rheumatology and Immunology Center, China Medical University Hospital, No. 2, Yude Road, Taichung, 40447, Taiwan.

Background: Increasing evidence indicates a pathogenic role of deregulated autophagy in rheumatoid arthritis (RA). We examined the relationship between autophagy and inflammatory parameters in patients with RA receiving biologic therapy.

Methods: In 72 patients with RA and 20 healthy control subjects (HC), autophagosome levels were determined by the mean fluorescence intensity (MFI) of autophagosomotropic dye incorporated into circulating immune cells, and p62 expression levels in immune cells were measured by flow cytometry. Read More

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December 2018
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The Perceived Stress Scale-10 (PSS-10) is reliable and has construct validity in Chinese patients with systemic lupus erythematosus.

Lupus 2018 Dec 5:961203318815595. Epub 2018 Dec 5.

1 School of Nursing, Tianjin Medical University, Tianjin City, People's Republic of China.

Systemic lupus erythematosus is a chronic, progressive, autoimmune disease that causes significant stress on patients. There is no specific instrument for assessing stress in Chinese systemic lupus erythematosus patients. The objective of this study was to test the reliability and validity of the 10-item Perceived Stress Scale in Chinese systemic lupus erythematosus patients. Read More

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December 2018
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Cross-sectional associations of vitamin D status with asthma prevalence, exacerbations, and control in New Zealand adults.

J Steroid Biochem Mol Biol 2018 Nov 30. Epub 2018 Nov 30.

School of Population Health, The University of Auckland, Auckland, New Zealand. Electronic address:

Background: Previous studies, mostly with children, have reported inconsistent findings on the associations of vitamin D status with asthma prevalence, exacerbations, and control. Because of limited research with adults, we examined these associations in a large community-based sample of New Zealand adults.

Methods: 5110 participants, aged 50-84 years, were recruited from the community into a clinical trial of vitamin D supplementation. Read More

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November 2018

Assessment of osteoarthritic features in the thumb base with the newly developed OMERACT magnetic resonance imaging scoring system is a valid addition to standard radiography.

Osteoarthritis Cartilage 2018 Nov 30. Epub 2018 Nov 30.

Departments of Rheumatology, Leiden University Medical Center (LUMC), Leiden, the Netherlands; Clinical Epidemiology, Leiden University Medical Center (LUMC), Leiden, the Netherlands. Electronic address:

Objective: To investigate the construct validity of the new thumb base OA MRI scoring system (TOMS) by comparing TOMS scores with radiographic scores in patients with primary hand OA.

Design: In 200 patients (83.5% women, mean (SD) age 61. Read More

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November 2018

Mesenchymal stem cells to treat type 1 diabetes.

Authors:
John S Pixley

Biochim Biophys Acta Mol Basis Dis 2018 Nov 30. Epub 2018 Nov 30.

Division of Rheumatology/Immunology, Department of Medicine, Texas Tech University Health Science Center, 3601 4th Street, MS 9410, Lubbock, TX 79430, USA. Electronic address:

What is clear is we are in the era of the stem cell and its potential in ameliorating human disease. Our perspective is generated from an in vivo model in a large animal that offers significant advantages (complete transplantation tolerance, large size and long life span). This review is an effort to meld our preclinical observations with others for the reader and to outline potential avenues to improve the present outlook for patients with diabetes. Read More

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November 2018

Switched CD21 B cells with an antigen-presenting phenotype in the infant thymus.

J Allergy Clin Immunol 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology and Inflammation Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Half of all B cells in the human thymus are mature CD21 AIRE-expressing cells with a professional antigen presenting cell phenotype, implying a role in T-cell selection and therefore critical in preventing autoimmunity. Read More

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November 2018

How Would You Manage This Patient With Gout?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Ann Intern Med 2018 Dec;169(11):788-795

Beth Israel Deaconess Medical Center, Boston, Massachusetts (R.B.B., C.C.S., R.H.S., A.T.).

Gout is the most common form of inflammatory arthritis. In 2012, the American College of Rheumatology (ACR) issued a guideline, which was followed in 2017 by one from the American College of Physicians (ACP). The guidelines agree on treating acute gout with a corticosteroid, nonsteroidal anti-inflammatory drug, or colchicine and on not initiating long-term urate-lowering therapy (ULT) for most patients after a first gout attack and in those whose attacks are infrequent (<2 per year). Read More

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December 2018

Evidence of an Anti-inflammatory Toll-like Receptor 9 (TLR 9) Pathway in Adipocytes.

J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

T Karrasch, Department of Internal Medicine III, Giessen University Hospital, Giessen, 35392, Germany.

Adipocytes express various pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and actively participate in anti-bacterial and anti-viral host defence. Obesity is associated with adipose tissue PRR expression. The potential role of Toll-like receptor 9 (TLR9) in adipocytes has not yet been investigated. Read More

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December 2018

Self-glycerophospholipids activate murine phospholipid-reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading.

Eur J Immunol 2018 Dec 3. Epub 2018 Dec 3.

Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine.

Glycosphingolipids and glycerophospholipids bind CD1d. Glycosphingolipid-reactive invariant NKT-cells (iNKT) exhibit myriad immune effects, however, little is known about the functions of phospholipid-reactive T-cells (PLT). We report that the normal mouse immune repertoire contains αβ T-cells, which recognize self-glycerophospholipids such as phosphatidic acid (PA) in a CD1d-restricted manner and don't cross-react with iNKT-cell ligands. Read More

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December 2018
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Efficacy of dual antiplatelet therapy for preventing recurrence of arterial thrombosis in patients with antiphospholipid syndrome.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objective: Warfarin is regarded as the standard treatment for preventing thrombotic events in APS, but the recurrence rate is still high. Dual antiplatelet therapy (DAPT) has been shown to be effective for the prevention of acute coronary syndrome or stroke. The objective of this study was to evaluate the efficacy of DAPT for the prevention of thrombosis recurrence in APS patients with history of arterial thrombosis. Read More

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November 2018

Increased expression of the TNF superfamily member LIGHT/TNFSF14 and its receptors (HVEM and LTßR) in patients with systemic sclerosis.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.

Objectives: This study aimed to assess the potential role of the TNF superfamily member lymphocyte T-related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells (LIGHT) in SSc through evaluation of: skin expression of LIGHT and its receptors, herpesvirus entry mediator and lymphotoxin ß-related receptor, and serum concentration of LIGHT in SSc patients.

Methods: Expression of LIGHT and its receptors was investigated by immunohistochemistry and evaluated semi-quantitatively in skin biopsies from 19 SSc patients and 9 healthy controls. Serum levels of LIGHT were measured using ELISA in 329 patients with SSc and 50 control subjects. Read More

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November 2018

Cardiorespiratory fitness in long-term juvenile dermatomyositis: a controlled, cross-sectional study of active/inactive disease.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology, Oslo University Hospital, Rikshospitalet.

Objectives: To compare cardiorespiratory fitness (CRF) expressed as maximal oxygen uptake (VO2max) between patients with long-term JDM and controls and between patients with active and inactive disease, as well as to explore exercise limiting factors and associations between CRF and disease variables.

Methods: JDM patients (n = 45) and age- and gender-matched controls (n = 45) performed a cardiopulmonary exercise test (CPET) on a treadmill until exhaustion. Physical activity was measured by accelerometers. Read More

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November 2018

Association of HLA-DRB1 shared epitope alleles and immune checkpoint inhibitor-induced inflammatory arthritis.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objective: To evaluate the frequency of HLA class I and II alleles associated with traditional forms of inflammatory arthritis in patients with immune checkpoint inhibitor (ICI)-induced inflammatory arthritis as compared with population controls.

Methods: High-resolution HLA typing was performed on 27 patients with ICI-induced inflammatory arthritis and 726 healthy controls. Genotyping at the shared epitope (SE) locus (HLA DRB1) was performed on 220 RA cases. Read More

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November 2018

Assessments of the unmet need in the management of patients with rheumatoid arthritis: analyses from the NOR-DMARD registry.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.

Objective: To describe the outcomes of MTX and biologic DMARD (bDMARD) treatment in patients with RA and assess unmet needs in patients who fail treatment, using real-world data from the Norwegian DMARD (NOR-DMARD) registry.

Methods: Data included RA treatment courses from January 2007 until July 2016. Patients received MTX monotherapy (in MTX-naïve patients), bDMARD monotherapy, bDMARDs + MTX, or bDMARDs + other conventional synthetic DMARDs (csDMARDs). Read More

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November 2018
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CD4+CXCR4+ T cells as a novel prognostic biomarker in patients with idiopathic inflammatory myopathy-associated interstitial lung disease.

Rheumatology (Oxford) 2018 Dec 1. Epub 2018 Dec 1.

Department of Rheumatology, Ren Ji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.

Backgroud: There is an unmet need for the development of new biomarkers for idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD).

Methods: Peripheral CD4+CXCR4+ T cells, stromal cell-derived factor-1 and Krebs von den Lungen-6 were measured in patients with IIM-ILD (n = 85) and controls. The relation to pulmonary functions, high-resolution CT scores, specific clinical phenotypes and survival was analysed. Read More

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December 2018

The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-β1.

Rheumatology (Oxford) 2018 Dec 1. Epub 2018 Dec 1.

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Objective: To investigate the role of AXL, a member of the anti-inflammatory TYRO3, AXL MER (TAM) receptor family, in arthritis.

Methods: KRN serum transfer arthritis was induced in Axl-/- and wild-type mice. Knee and ankle joints were scored macro- and microscopically. Read More

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December 2018

Clinical significance of Janus Kinase inhibitor selectivity.

Authors:
Ernest H Choy

Rheumatology (Oxford) 2018 Dec 1. Epub 2018 Dec 1.

CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.

Cytokines are key drivers of inflammation in RA, and anti-cytokine therapy has improved the outcome of RA. Janus Kinases (JAK) are intracellular tyrosine kinases linked to intracellular domains of many cytokine receptors. There are four JAK isoforms: JAK1, JAK2, JAK3 and TYK2. Read More

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December 2018

Serum IP-10 levels and increased DPPIV activity are linked to circulating CXCR3+ T cells in cholestatic HCV patients.

PLoS One 2018 3;13(12):e0208225. Epub 2018 Dec 3.

Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany.

Background & Aims: Serum interferon-gamma-inducible protein-10 (IP-10) is elevated in cholestatic liver diseases and predicts response to antiviral therapy in patients with chronic hepatitis C virus (HCV) infection. Dipeptidylpeptidase 4 (DPPIV) cleaves active IP-10 into an inactive form, which inhibits recruitment of CXCR3+ T cells to the liver. In this study the link between IP-10 levels, DPPIV activity in serum and CXCR3+ T cells is analysed in cholestatic and non-cholestatic liver patients. Read More

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December 2018
1 Read

Is Sjögren's syndrome dry eye similar to dry eye caused by other etiologies? Discriminating different diseases by dry eye tests.

PLoS One 2018 3;13(12):e0208420. Epub 2018 Dec 3.

Department of Ophthalmology, Otorhinolaryngology and Head & Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Purpose: Dry Eye Disease (DED) is part of several conditions, including Sjögren's syndrome (SS) and no single test to diagnosis DED. The present study intends to evaluate whether a set of signs and symptoms of DED can distinguish: a) SS from other non-overlapping systemic diseases related to DED; b) primary and secondary SS.

Methods: 182 consecutive patients with DED were evaluated under five groups: SS, graft-versus-host disease (GVHD), Graves' orbitopathy (GO), diabetes mellitus (DM), glaucoma under treatment with benzalkonium chloride medications (BAK). Read More

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December 2018