106,712 results match your criteria Rheumatology News[Journal]


Digital PCR in bone marrow trephine biopsies is highly sensitive for MYD88 detection in lymphomas with plasmacytic/plasmacytoid differentiation.

Br J Haematol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Pathology, Neuropathology and Molecular Pathology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1111/bjh.15792DOI Listing
February 2019
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A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models.

J Clin Epidemiol 2019 Feb 11. Epub 2019 Feb 11.

KU Leuven, Department of Development & Regeneration, Herestraat 49 box 805, 3000 Leuven, Belgium; Department of Biomedical Data Sciences, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:

Objective: To compare performance of logistic regression (LR) with machine learning (ML) for clinical prediction modeling.

Study Design And Setting: We conducted a Medline literature search (1/2016 to 8/2017), and extracted comparisons between LR and ML models for binary outcomes.

Results: We included 71 out of 927 studies. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2019.02.004DOI Listing
February 2019

Temporomandibular Disorder: An Important Cause of Temporal Headache in Patients Unlikely to Have Giant Cell Arteritis.

Semin Ophthalmol 2019 Feb 14:1-5. Epub 2019 Feb 14.

a Tennent Institute of Ophthalmology , Gartnavel General Hospital , Glasgow , UK.

Introduction: Temporal headache often results in an Ophthalmology referral to rule out giant cell arteritis (GCA). When clinical suspicion of GCA is low, alternative diagnoses should be considered. Temporomandibular disorder (TMD) commonly causes a temporal headache. Read More

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http://dx.doi.org/10.1080/08820538.2019.1578383DOI Listing
February 2019

Skin inflammation associated with arthritis, synovitis and enthesitis. Part 2: rheumatoid arthritis, reactive arthritis, Reiter's syndrome, Lyme borreliosis, dermatomyositis and lupus erythematosus.

J Dtsch Dermatol Ges 2019 Feb;17(2):167-181

Department of Rheumatology and clinical Immunology, Freiburg University Medical Center, Medical Faculty, Albert Ludwigs University, Freiburg, Germany.

Syndromes associated with concurrent skin and joint inflammation frequently pose a therapeutic challenge for both dermatologists and rheumatologists. In part 1 of this review, we discussed psoriatic arthritis as well as the autoinflammatory disorders SAPHO syndrome, Still's disease and Behçet's disease. Part 2 will address rheumatoid arthritis, reactive arthritis, Reiter's syndrome and Lyme borreliosis. Read More

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http://dx.doi.org/10.1111/ddg.13761DOI Listing
February 2019

Prevalence, Treatment and Outcomes of Coexistent Pulmonary Hypertension and Interstitial Lung Disease in Systemic Sclerosis.

Arthritis Rheumatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Rheumatology, Department of Internal Medicine, University of Michigan.

Objective: Systemic sclerosis (SSc) is associated with interstitial lung disease (ILD) and pulmonary hypertension (PH). We sought to determine prevalence, characteristics, treatment, and outcomes for subjects with PH in a SSc-associated ILD (SSc-ILD) cohort.

Methods: Subjects with SSc-ILD on high resolution computed tomography (HRCT) were included in a prospective observational cohort. Read More

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http://dx.doi.org/10.1002/art.40862DOI Listing
February 2019

IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: An observational study.

Medicine (Baltimore) 2019 Feb;98(7):e14587

Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila.

Recently, it has been shown that some well-known pathogenic mediators in rheumatoid arthritis (RA), such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), could play a pathogenic role in insulin resistance and (IR) and type 2 diabetes (T2D).In this 6-month longitudinal study, we aimed at investigating if the inhibition of IL-1 or TNF is associated with an improvement of IR in RA patients with comorbid T2D and the possible effects on selected serum adipokines. RA patients with comorbid T2D were recruited among those undergoing treatment with anakinra (ANA) or with TNF inhibitor (TNFi). Read More

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http://dx.doi.org/10.1097/MD.0000000000014587DOI Listing
February 2019

Characteristics of late-onset spondyloarthritis in Japan: A retrospective cohort study.

Medicine (Baltimore) 2019 Feb;98(7):e14431

Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences.

Spondyloarthritis may be increasingly present in older patients as life expectancy increases. We investigated clinical differences between early-onset and late-onset spondyloarthritis in Japan.We retrospectively reviewed 114 patients consecutively diagnosed with spondyloarthritis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014431DOI Listing
February 2019

Cognitive outcomes of childhood primary CNS vasculitis.

Neuropsychology 2019 Feb 14. Epub 2019 Feb 14.

Alberta Children's Hospital Research Institute, Department of Pediatrics, Cumming School of Medicine, University of Calgary.

Objective: To characterize the clinical cognitive phenotypes and severity of cognitive burden according to disease subtype in children with primary central nervous system vasculitis (cPACNS).

Method: This retrospective multicenter inflammatory brain disease database study examined the neuropsychological outcomes of 80 children (44 male; mean age = 7.89 years, SD = 4. Read More

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http://dx.doi.org/10.1037/neu0000513DOI Listing
February 2019

The impact of smoking on response to TNF inhibitors in axial spondyloarthritis: methodological considerations for longitudinal observational studies.

Arthritis Care Res (Hoboken) 2019 Feb 14. Epub 2019 Feb 14.

Musculoskeletal biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

Objective: Observational data facilitate examination of treatment-effect heterogeneity, but the risk of bias is substantial. We highlight methodological considerations through an analysis of whether smoking affects response to TNF inhibitors (TNFi) in axial spondyloarthritis (axSpA).

Methods: We used longitudinal data from the British Society for Rheumatology Biologics Register for Ankylosing Spondylitis. Read More

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http://dx.doi.org/10.1002/acr.23851DOI Listing
February 2019

Long-term outcomes in juvenile idiopathic arthritis: 18 years of follow-up in the population-based Nordic Juvenile Idiopathic Arthritis (JIA) cohort.

Arthritis Care Res (Hoboken) 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.

Objectives: This study assessed the long-term course, remission rate and disease burden in juvenile idiopathic arthritis (JIA) 18 years after disease onset in a population-based setting from the early biologic era.

Methods: A total of 510 consecutive cases of JIA with disease onset between 1997 and 2000 from defined geographic regions in Denmark, Norway, Sweden and Finland were prospectively included in this 18-year cohort study. At the follow-up visit, patient-reported, demographic and clinical data were collected. Read More

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http://dx.doi.org/10.1002/acr.23853DOI Listing
February 2019

Long-term efficacy and safety of biosimilar infliximab (CT-P13) after switching from originator infliximab: Open-label extension of the NOR-SWITCH trial.

J Intern Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Rheumatology, Diakonhjemmet Hospital, Oslo.

Background And Objectives: The 52-week, randomized, double blind, non-inferiority, government funded NOR-SWITCH trial demonstrated that switching from infliximab originator to less expensive biosimilar CT-P13 was not inferior to continued treatment with infliximab originator. The NOR-SWITCH extension trial aimed to assess efficacy, safety and immunogenicity in patients on CT-P13 throughout the 78-week study period (maintenance group) vs patients switched to CT-P13 at week 52 (switch group).

Primary Outcome: disease worsening during follow-up based on disease specific composite measures. Read More

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http://dx.doi.org/10.1111/joim.12880DOI Listing
February 2019

Efficacy and safety of tyrosine kinase inhibitors for newly diagnosed chronic-phase chronic myeloid leukemia over a 5-year period: results from the Japanese registry obtained by the New TARGET system.

Int J Hematol 2019 Feb 14. Epub 2019 Feb 14.

National Hospital Organization Nagoya Medical Center, Nagoya, Japan.

We report the results of a multicenter observational study using the New TARGET system, in which the effectiveness and safety of tyrosine kinase inhibitors (TKIs) were evaluated in newly diagnosed chronic-phase chronic myeloid leukemia (CML) patients. A total of 506 patients were enrolled between April 2010 and March 2013. Median age was 56 (range 18-92) years; 35% of patients were females. Read More

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http://dx.doi.org/10.1007/s12185-019-02613-1DOI Listing
February 2019

Real-world effectiveness and safety of rituximab in the treatment of rheumatoid arthritis: A single-center experience in Taiwan.

Int J Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Aim: To assess the real-world effectiveness and safety of rituximab (RTX) at 24 months in patients with established rheumatoid arthritis (RA) and to identify predictors of low disease activity/remission and a good European League Against Rheumatism (EULAR) response.

Methods: Seventy RTX-treated RA patients were enrolled. Predictors for low disease activity/remission and a good EULAR response at 24 months were identified by multivariate analyses. Read More

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http://dx.doi.org/10.1111/1756-185X.13511DOI Listing
February 2019

Overexpression of apoptosis-related protein, survivin, in fibroblasts from patients with systemic sclerosis.

Ir J Med Sci 2019 Feb 13. Epub 2019 Feb 13.

Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background/objectives: Recent studies suggest that, in addition to activation and hypersecretion of matrix components, fibroblasts from patients with systemic sclerosis (SSc) are resistant to apoptosis. Previous studies have shown that survivin, a member of inhibition of apoptosis (IAP) family, plays an important role in apoptosis resistance. Accordingly, we decided to study the expression of the most important members of IAP family in SSc fibroblasts, which can block apoptosis either by binding and inhibiting caspases or through caspase-independent mechanisms. Read More

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http://dx.doi.org/10.1007/s11845-019-01978-wDOI Listing
February 2019

The immunogenicity of seasonal and pandemic influenza vaccination in autoimmune inflammatory rheumatic patients-a 6-month follow-up prospective study.

Clin Rheumatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, 1000, Slovenia.

Introduction: Influenza may cause severe complications in patients with autoimmune inflammatory rheumatic disease (AIRD), to whom vaccinations are especially recommended. However, AIRD patients require cautious scrutiny of immunogenicity as they might exhibit poor antibody response to vaccination, especially when taking immunomodulatory medications.

Aim: The aim was to determine immunogenicity of seasonal and pandemic influenza vaccine in AIRD patients, its timeline/persistence, and influence of medications on immune response. Read More

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http://dx.doi.org/10.1007/s10067-019-04439-yDOI Listing
February 2019

Osteoporosis strategic plan for the Middle East and North Africa region.

Arch Osteoporos 2019 Feb 14;14(1):20. Epub 2019 Feb 14.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Shariati Hospital, Tehran University of Medical Sciences, Kargar st., Tehran, Iran.

The first step to achieve a world without fragility fractures is to devise a strategic plan to improve research and planning, and assisting member states to acquire the required financial, technical, and other resources. This article aims to outline the first strategic plan devised for the Middle East and North Africa region proposed by the International Osteoporosis Foundation's (IOF) Middle East and North Africa (MENA) Regional Advisory Council (RAC).

Purpose: Osteoporosis is no exception in this rising tide of non-communicable diseases, not only sharing common risk factors but also contributing substantially to a heavy social and economic burden on society. Read More

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http://dx.doi.org/10.1007/s11657-019-0567-4DOI Listing
February 2019

Thirty Years of Kawasaki Disease: A Single-Center Study at the University Hospital of Lausanne.

Front Pediatr 2019 30;7:11. Epub 2019 Jan 30.

Pediatric Cardiology Unit, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Kawasaki disease is an acute vasculitis with a particular involvement of the coronary arteries. Coronary artery aneurysms develop in 20% of untreated children. It has been shown that early treatment with intravenous immunoglobulins and aspirin decreases this risk to 5%, but the medium to long term prognosis of children with Kawasaki disease is still unclear. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00011/
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http://dx.doi.org/10.3389/fped.2019.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363689PMC
January 2019
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Acquired and Innate Immunity Impairment and Severe Disseminated Infection in a Patient With a NF-κB1 Deficiency.

Front Immunol 2018 29;9:3148. Epub 2019 Jan 29.

Research Institute Hospital 12 Octubre (I+12), Madrid, Spain.

NF-κB1 is a master regulator of both acquired and innate responses. loss-of-function mutations elicit a wide clinical phenotype with asymptomatic individuals at one end of the spectrum and patients with common variable immunodeficiency, combined immunodeficiency or autoinflammation at the other. Impairment of acquired and innate immunity and disseminated infection expands the clinical and immunological phenotype of NF-κB1 deficiency. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362422PMC
January 2019

Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis.

Front Immunol 2019 29;10:83. Epub 2019 Jan 29.

Department Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Giant cell arteritis (GCA) can be classified into Cranial(C)-GCA and Large Vessel(LV)-GCA. Based on analysis of temporal arteries, GCA is postulated to be T-cell-mediated. Recently, a disturbed B-cell homeostasis was documented in newly diagnosed GCA patients. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00083
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http://dx.doi.org/10.3389/fimmu.2019.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361817PMC
January 2019
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Multidrug-Resistant Accelerate Intestinal, Extra-Intestinal, and Systemic Inflammatory Responses in Human Microbiota-Associated Mice With Subacute Ileitis.

Front Immunol 2019 29;10:49. Epub 2019 Jan 29.

Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Berlin Institute of Health, Charité - University Medicine Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

The globally rising incidences of multidrug-resistant (MDR) (Psae) in humans and live-stock animals has prompted the World Health Organization to rate MDR Psae as serious threat for human health. Only little is known, however, regarding factors facilitating gastrointestinal Psae-acquisition by the vertebrate host and subsequently induced inflammatory sequelae. In the present study, we addressed whether subacute ileitis predisposed mice harboring a human gut microbiota for intestinal MDR Psae carriage and whether inflammatory responses might be induced following peroral challenge with the opportunistic pathogen. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361842PMC
January 2019

Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism.

Front Immunol 2019 28;10:30. Epub 2019 Jan 28.

Laboratory of Dendritic Cell Biology, Department of Microbiology-Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

Attenuating the innate immunity activation could ameliorate inflammation and disease in settings such as transplant rejection or autoimmunity. Recently, a pivotal role for metabolic re-programming in TLR-induced dendritic cell (DC) activation has emerged. Ethyl pyruvate (EP), a pyruvate derivative, possesses anti-inflammatory properties and in animal models of disease. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362406PMC
January 2019

Correction: Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Pharmacogenomics J 2019 Feb 14. Epub 2019 Feb 14.

Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain.

The original version of this Article contained an error in the spelling of the author Ana Rodríguez-Ramos, which was incorrectly given as Ana Rodríguez Ramos. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41397-019-0084-2DOI Listing
February 2019

Impact of diverse chemotherapeutic agents and external factors on activation of brown adipose tissue in a large patient collective.

Sci Rep 2019 Feb 13;9(1):1901. Epub 2019 Feb 13.

Diagnostic and Interventional Radiology, Department of Radiology, Eberhard Karls University, Hoppe-Seyler-Straße 3, 72076, Tuebingen, Germany.

Increased activity of brown adipose tissue (BAT) activity in adults is thought to prevent obesity. Therefore, regulators of BAT activity might serve as anti-obesity therapy in future, but are not investigated thoroughly up to now. In our study, we assessed retrospectively the association of BAT activity with several external factors and diverse chemotherapeutic and immunosuppressive agents in a collective of 702 patients. Read More

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http://dx.doi.org/10.1038/s41598-018-37924-6DOI Listing
February 2019

Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells.

Cell Death Dis 2019 Feb 13;10(2):140. Epub 2019 Feb 13.

Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China.

Baicalin is a natural compound isolated from Chinese herb, which has been reported as an anti-inflammatory drug. Here, we demonstrated that Baicalin treatment could reduce urine protein, inhibit anti-ds-DNA antibody titers, and ameliorate lupus nephritis in MRL/lpr lupus-prone mice. Baicalin inhibited Tfh cell differentiation and IL-21 production, but promoted Foxp3 regulatory T cell differentiation including part of follicular regulatory T (Tfr) cells. Read More

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http://dx.doi.org/10.1038/s41419-019-1315-9DOI Listing
February 2019

Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome.

J Immunol 2019 Feb 13. Epub 2019 Feb 13.

Department of Laboratory Medicine, Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, China;

Although the expansion of myeloid-derived suppressor cells (MDSCs) has been reported in autoimmune disorders, it is largely unclear how MDSCs contribute to the development of primary Sjögren syndrome (pSS). In this study, we found significantly increased MDSCs with gradually diminished suppressive capacity during disease development in mice with experimental Sjögren syndrome (ESS). The ligand for glucocorticoid-induced TNFR family-related protein (GITRL) was increased along ESS progression, whereas the increased GITRL was found to attenuate the immunosuppressive function of MDSCs. Read More

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http://dx.doi.org/10.4049/jimmunol.1801051DOI Listing
February 2019

Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility.

Life Sci Alliance 2019 Feb 13;2(1). Epub 2019 Feb 13.

Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK

Epithelial cells form sheets and tubules in various epithelial organs and establish apicobasal polarity and asymmetric vesicle transport to provide functionality in these structures. However, the molecular mechanisms that allow epithelial cells to establish polarity are not clearly understood. Here, we present evidence that the kinase activity of the receptor tyrosine kinase for collagen, discoidin domain receptor 1 (DDR1), is required for efficient establishment of epithelial polarity, proper asymmetric protein secretion, and execution of morphogenic programs. Read More

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http://dx.doi.org/10.26508/lsa.201800276DOI Listing
February 2019

Response to 'Everything we see is a perspective, not the truth' by Chattopadhyay .

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Rheumatology, Cochin Hospital, Assistance Publique- Hôpitaux de Paris, Paris, France

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http://dx.doi.org/10.1136/annrheumdis-2019-215131DOI Listing
February 2019

in individuals at risk for rheumatoid arthritis.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany

Objectives: Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of spp. in a group of individuals at increased risk for RA, but prior to the development of the disease. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214514DOI Listing
February 2019

[18F]Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

The National Institute for Health Research Manchester Musculoskeletal Biomedical Research Centre, Manchester University Hospitals NHS FoundationTrust, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

Objectives: With the tools available currently, confirming the diagnosis of inclusion body myositis (IBM) can be difficult. Many patients are initially misdiagnosed with polymyositis (PM). In this observational study at a UK adult neuromuscular centre, we investigated whether amyloid positron emission tomography could differentiate between IBM and PM. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214644DOI Listing
February 2019

'Everything we see is a perspective, not the truth'.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Clinical immunology and Rheumatology services, Post Graduate Institute of Medical Education & Research, Chandigarh, Punjab, India.

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http://dx.doi.org/10.1136/annrheumdis-2019-215109DOI Listing
February 2019

NOD2 signaling pathway is involved in fibronectin fragment-induced pro-catabolic factor expressions in human articular chondrocytes.

BMB Rep 2019 Feb 14. Epub 2019 Feb 14.

Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, 14068, Korea; Institute for Skeletal Aging, Hallym University, Chunchon, 24251, Korea.

The nucleotide-binding and oligomerization domain (NOD) is an innate pattern recognition receptor that recognizes pathogen- and damage-associated molecular patterns. The 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) is a matrix degradation product found in the synovial fluids of patients with osteoarthritis (OA). We investigated whether NOD2 was involved in 29-kDa FN-f-induced pro-catabolic gene expression in human chondrocytes. Read More

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February 2019

Epigenetic findings in periodontitis in UK twins: a cross-sectional study.

Clin Epigenetics 2019 Feb 13;11(1):27. Epub 2019 Feb 13.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.

Background: Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms are malleable regulators of gene function that can change in response to genetic and environmental stimuli, thereby providing a potential mechanism for mediating risk effects in periodontitis. The aim of this study is to identify epigenetic changes across tissues that are associated with periodontal disease. Read More

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http://dx.doi.org/10.1186/s13148-019-0614-4DOI Listing
February 2019

Efficacy of canakinumab as first-line biologic agent in adult-onset Still's disease.

Arthritis Res Ther 2019 Feb 13;21(1):54. Epub 2019 Feb 13.

Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy.

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http://dx.doi.org/10.1186/s13075-019-1843-9DOI Listing
February 2019

Developing strategic priorities in osteoarthritis research: Proceedings and recommendations arising from the 2017 Australian Osteoarthritis Summit.

BMC Musculoskelet Disord 2019 Feb 13;20(1):74. Epub 2019 Feb 13.

Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Australia.

Background: There is a pressing need to enhance osteoarthritis (OA) research to find ways of alleviating its enormous individual and societal impact due to the high prevalence, associated disability, and extensive costs.

Methods: Potential research priorities and initial rankings were pre-identified via surveys and the 1000Minds process by OA consumers and the research community. The OA Summit was held to decide key research priorities that match the strengths and expertise of the Australian OA research community and align with the needs of consumers. Read More

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http://dx.doi.org/10.1186/s12891-019-2455-xDOI Listing
February 2019

Inflammasome Signaling and Impaired Vascular Health in Psoriasis.

Arterioscler Thromb Vasc Biol 2019 Feb 14:ATVBAHA118312246. Epub 2019 Feb 14.

From the Center for the Prevention of Cardiovascular Disease, Department of Medicine, New York University School of Medicine (M.S.G., E.A.F., J.S.B.).

Objective- Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial health and systemically altered pathways in psoriasis and matched controls. Approach and Results- Twenty patients (mean age, 40 years; 50% male) with active psoriasis and 10 age-, sex-matched controls were recruited. Read More

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http://dx.doi.org/10.1161/ATVBAHA.118.312246DOI Listing
February 2019

A paradigm shift in studies based on rheumatoid arthritis clinical registries.

Korean J Intern Med 2019 Feb 18. Epub 2019 Feb 18.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Clinical research is the study of aspects of patient health or illness that are closely related to clinical practice. In the late 20th and early 21th century, outcomes for patients with rheumatoid arthritis (RA) improved dramatically due to breakthroughs in new drugs. Patient-reported outcome measures now play a significant role in the drug development process as study endpoints in clinical trials of new therapies, and this has led to increased interest in the patient's perspective, drug safety and treatment outcomes in clinical practice. Read More

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http://kjim.org/journal/view.php?doi=10.3904/kjim.2018.440
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http://dx.doi.org/10.3904/kjim.2018.440DOI Listing
February 2019
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Neurosyphilis Presenting with Papillitis.

Eur J Case Rep Intern Med 2017 5;4(9):000718. Epub 2017 Sep 5.

Undergraduate Medical School, University of Glasgow, Glasgow, UK.

Syphilis is one of the oldest described infectious diseases in the world and is caused by the spirochete bacterium . Although now a rare disease, incidence is increasing with the number of diagnoses of the disease rising in England from 1688 to 2713 between 2003 and 2012 (a 61% increase). Major outbreaks of syphilis have been documented in London, Manchester, Dublin, and Brighton particularly among men who have sex with men (MSM). Read More

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http://dx.doi.org/10.12890/2017_000718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346848PMC
September 2017

Raynaud's of the Tongue.

Eur J Case Rep Intern Med 2017 1;4(8):000689. Epub 2017 Aug 1.

Undergraduate Medical School, University of Dundee, Dundee, UK.

We describe a 40-year-old lady who presents with a painful white tongue on exposure to the cold. The differential diagnosis and investigations are outlined with a discussion about this unusual presentation of a common problem.

Learning Points: Raynaud's can affect areas of the body besides the digits. Read More

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http://dx.doi.org/10.12890/2017_000689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346859PMC

Dermatomyositis Associated with Sarcoidosis: Two Cases.

Eur J Case Rep Intern Med 2017 27;4(1):000500. Epub 2017 Jan 27.

Department of Rheumatology and Physical Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Dermatomyositis (DM) and sarcoidosis are two idiopathic systemic disorders. Reports of patients with both conditions are extremely rare. Here we describe two patients who presented with DM and DM-associated antibodies, and later developed biopsy-proven sarcoidosis. Read More

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http://dx.doi.org/10.12890/2016_000500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346918PMC
January 2017

More Than Just a Case of Polymyalgia Rheumatica.

Eur J Case Rep Intern Med 2016 23;3(3):000374. Epub 2016 Feb 23.

Department A of Internal Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Malignant neoplasms are associated with a wide range of paraneoplastic rheumatological syndromes. These can be defined as remote effects of cancer, which are not caused by the tumor and its metastasis. The authors describe the case of an 82-year-old man, who presented with a one-month history of pain, stiffness, and functional limitation of the scapular and pelvic girdles. Read More

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http://dx.doi.org/10.12890/2016_000374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346904PMC
February 2016

Treatment and management of osteoporosis-pseudoglioma syndrome.

Authors:
Régis Levasseur

Expert Rev Endocrinol Metab 2008 May;3(3):337-348

a Rheumatology Department, Angers Teaching Hospital, Service de Rhumatologie et Pôle ostéo-articulaire, CHU d'Angers, Inserm U922, Faculté de Médecine d'Angers, 4 rue Larrey, 49460 Angers, France.

Osteoporosis-pseudoglioma syndrome (OPPG; MIM 259770) is a very rare genetic disorder with an autosomal recessive mode of inheritance, characterized by congenital or infancy-onset visual loss and skeletal fragility, diagnosed during childhood. This syndrome can lead to severe disability and chronic bone pain. Low-density lipoprotein receptor-related protein 5 (LRP5) is the gene mutated and inactivated in OPPG, and plays a pivotal role in bone accrual and skeletal remodeling by controlling bone formation through activators, such as Wnt proteins, or inhibitors, such as DKK1. Read More

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http://dx.doi.org/10.1586/17446651.3.3.337DOI Listing

Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4 Foxp3 Regulatory T Cells.

Cell Rep 2019 Feb;26(7):1869-1879.e3

Division of Rheumatology, Department of Medicine, Penn State College of Medicine, Hershey, PA, USA. Electronic address:

High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.066DOI Listing
February 2019
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Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus.

J Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory Medicine Unit, Department of Medicine, University of Padova, Padua, Italy.

Background And Aims: Diabetes mellitus is recognized as one of the major causes of end stage kidney disease. Bone Gla protein (BGP) is a vitamin K-dependent protein involved in bone mineralization and vascular calcifications (VC). Our goal was to characterize BGP and undercarboxylated BGP (ucBGP) in DM patients on HD, compared to HD patients without DM, and their association with vascular and bone disease. Read More

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http://dx.doi.org/10.1007/s40620-019-00595-1DOI Listing
February 2019

Venous vessel wall thickness in lower extremity is increased in male patients with Behcet's disease.

Clin Rheumatol 2019 Feb 13. Epub 2019 Feb 13.

Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey.

Vascular involvement, especially in young males, is seen in up to 40% of the patients with Behcet's disease (BD) and is a major cause of mortality and morbidity. In this study, we investigated vessel wall thickness (VWT) and dilatation in lower extremity veins with Doppler ultrasound (US) in male BD patients. Sixty-one male patients with BD, 37 healthy male controls (HC) and 27 male patients, with ankylosing spondylitis (AS), were included in the study. Read More

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http://dx.doi.org/10.1007/s10067-019-04470-zDOI Listing
February 2019

Reproductive rheumatology: the male perspective.

Clin Rheumatol 2019 Feb 13. Epub 2019 Feb 13.

Rheumatology Department, Northwick Park Hopsital, Harrow, London, UK.

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http://dx.doi.org/10.1007/s10067-019-04461-0DOI Listing
February 2019

Systemic Sclerosis and Serum Content of Transforming Growth Factor.

Adv Exp Med Biol 2019 Feb 14. Epub 2019 Feb 14.

Department of Rheumatology and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Systemic sclerosis is a connective tissue disease characterized by tissue fibrosis leading to interstitial lung disease. Transforming growth factor-β (TGF-β) has been of interest as a potential diagnostic marker and also as a drug target in systemic sclerosis. The aim of this study was to assess the serum content of TGF-β1 in patients with systemic sclerosis and to assess its potential role in tissue fibrosis. Read More

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http://link.springer.com/10.1007/5584_2019_341
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http://dx.doi.org/10.1007/5584_2019_341DOI Listing
February 2019
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Comparison of agreement between internet-based registration of patient-reported outcomes and clinic-based paper forms within the Swedish Rheumatology Quality Register.

Scand J Rheumatol 2019 Feb 13:1-5. Epub 2019 Feb 13.

a Department of Public Health and Clinical Medicine/Rheumatology , Umeå University , Umeå , Sweden.

Objective: The Swedish Rheumatology Quality Register has implemented an internet-based method (PER) for registering patient-recorded outcome measures. The aim of this study was to compare the agreement between visual analogue scales (VASs) reported via PER and clinic-based reporting using paper forms.

Methods: In a cross-sectional study (70 patients), the results of 79 registrations of VASs for global health, pain, and fatigue from PER were compared with corresponding clinic-based paper registrations. Read More

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http://dx.doi.org/10.1080/03009742.2018.1551964DOI Listing
February 2019

Knee Joint Distraction Compared with High Tibial Osteotomy and Total Knee Arthroplasty: Two-Year Clinical, Radiographic, and Biochemical Marker Outcomes of Two Randomized Controlled Trials.

Cartilage 2019 Feb 13:1947603519828432. Epub 2019 Feb 13.

1 Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

Objective: Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-preserving surgeries that postpone total knee arthroplasty (TKA) in younger osteoarthritis (OA) patients. Here we evaluate the 2-year follow-up of KJD versus TKA and KJD versus HTO in 2 noninferiority studies.

Design: Knee OA patients indicated for TKA were randomized to KJD ( n = 20; KJD) or TKA ( n = 40). Read More

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http://dx.doi.org/10.1177/1947603519828432DOI Listing
February 2019

Subclinical synovitis and enthesitis in psoriasis patients and controls by ultrasonography in Saudi Arabia; incidence of psoriatic arthritis during two years.

Clin Rheumatol 2019 Feb 12. Epub 2019 Feb 12.

Department Psychology, Health and Technology, Faculty of Behavioral, Management and Social sciences, University of Twente, PO box 217, 7500 AE, Enschede, The Netherlands.

Objective: To evaluate ultrasonographic subclinical inflammatory synovitis and enthesitis in psoriasis patients, without clinical arthritis or enthesitis compared with healthy controls, with a 2-year follow-up to study the associated incidence of psoriatic arthritis (PsA).

Methods: A total of 109 consecutive psoriasis vulgaris patients without clinical signs of PsA and 90 healthy controls were included from two tertiary medical centers. Subjects underwent dermatological examination, PASI score evaluation for severity of psoriasis, musculoskeletal examination using 68/66 joints count for tenderness and swollen joints. Read More

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http://dx.doi.org/10.1007/s10067-019-04445-0DOI Listing
February 2019