108,826 results match your criteria Rheumatology News[Journal]


Age dependent ultrasound B-mode findings of the elbow joint in healthy children and adolescents.

Rheumatol Int 2019 Apr 20. Epub 2019 Apr 20.

Department of Pediatrics, Asklepios Hospital Weißenfels, Naumburger Strasse 76, 06667, Weissenfels, Germany.

Due to maturation of joints, various changes take place, not only in the field of paediatric rheumatology but also in paediatric orthopaedics musculoskeletal ultrasound plays an important role in both the diagnosis and the follow-up of diseases in this field. To differentiate between physiological and pathological findings, the knowledge of reference values of joint structures is indispensable. The objective was to define B-mode ultrasound age- and sex-related reference values for the elbow joint in healthy children and adolescents during maturation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-018-4233-8DOI Listing
April 2019
1 Read

Establishment of an international autoantibody reference standard for human anti-DFS70 antibodies: proof-of-concept study for a novel Megapool strategy by pooling individual specific sera.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 740 3° andar, 04023-062 São Paulo, Brazil.

Background International autoantibody standards, traditionally based on material obtained from plasmapheresis of single subjects, represent individual immune response and may not comprehend the heterogeneity of the general population. The anti-DFS70 autoantibody yields a characteristic dense fine speckled (DFS) nuclear pattern on indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA) and speaks against autoimmunity. We propose a novel strategy for developing autoantibody reference standards, based on stepwise pooling of serum samples from hundreds of individuals with anti-DFS70 antibodies. Read More

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
Publisher Site
http://dx.doi.org/10.1515/cclm-2019-0087DOI Listing
April 2019
1 Read

The FOOTPATH study: protocol for a multicentre, participant- and assessor-blind, parallel group randomised clinical trial of foot orthoses for patellofemoral osteoarthritis.

BMJ Open 2019 Apr 20;9(4):e025315. Epub 2019 Apr 20.

La Trobe Sport and Exercise Medicine Research Centre, College of Science, Health and Engineering, La Trobe University, Melbourne, Victoria, Australia.

Introduction: Patellofemoral (PF) osteoarthritis (OA) is a common and burdensome subgroup of knee OA, with very little evidence for effective treatments. Prefabricated foot orthoses are an affordable and accessible intervention that have been shown to reduce PF pain in younger adults. Similarities between PF pain and PFOA, as well as our pilot work, suggest that foot orthoses may also be an effective intervention for PFOA. Read More

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02531
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-025315DOI Listing
April 2019
1 Read

Successful treatment of arthritis and rash with tofacitinib in systemic lupus erythematosus: the experience from a single centre.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, National Clinical Research Center on Rheumatology, Ministry of Science & Technology, Beijing, China

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2019-215455DOI Listing

Smoking does not protect patients with axial spondyloarthritis from attacks of uveitis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Musculoskeletal biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2019-215348DOI Listing

Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Paediatric Rheumatology and Immunology, University of Münster, Münster, Germany

Objectives: The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a 'window of opportunity' to abrogate the development of chronic arthritis. Read More

View Article

Download full-text PDF

Source
http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21505
Publisher Site
http://dx.doi.org/10.1136/annrheumdis-2019-215051DOI Listing
April 2019
1 Read

Pathogenic effector functions of ACPA: Where do we stand?

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Medicine, Duke University Medical Center and Medical Research Service, VA Medical Center, Durham, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2019-215337DOI Listing

Crohn's disease initiated with extraintestinal features.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts, USA.

Crohn's disease (CD) is a multifactorial, chronic immune-mediated disorder. The oral cavity is involved in 0.5% to 20% of the patients with CD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2019-229916DOI Listing
April 2019
1 Read

New therapeutic strategies based on IL-2 to modulate Treg cells for autoimmune diseases.

Int Immunopharmacol 2019 Apr 18;72:322-329. Epub 2019 Apr 18.

Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 30072, PR China. Electronic address:

Interleukin-2 (IL-2) is a multifunctional cytokine in immune regulation. It is essential for the differentiation, expansion and stability of CD25Foxp3 regulatory T (Treg) cells, which is an important factor in immune suppression and self-tolerance. Meanwhile, IL-2 also stimulate effector T (Teff) cells to promote immune responses. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15675769183113
Publisher Site
http://dx.doi.org/10.1016/j.intimp.2019.03.064DOI Listing
April 2019
1 Read

Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome.

Cytokine 2019 Apr 18;120:66-70. Epub 2019 Apr 18.

Applied Physiology & Nutrition Research Group, Laboratory of Assessment and Conditioning in Rheumatology, School of Physical Education and Sport, School of Medicine, University of São Paulo, Brazil; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil. Electronic address:

Polycystic ovary syndrome (PCOS) is characterized by exacerbated inflammation, which is implicated in cardiometabolic dysfunction. This study aimed to examine the potential effects of acute exercise on inflammatory responses in obese/overweight PCOS women and their controls. Participants underwent a single bout of moderate-intensity aerobic exercise (30 min at ∼65% of VO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cyto.2019.04.006DOI Listing

Association Between Homocysteine Serum Level and Bone Mineral Density in Patients With Rheumatoid Arthritis.

J Clin Densitom 2019 Mar 28. Epub 2019 Mar 28.

Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitario San Cecilio, Granada, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocd.2019.03.008DOI Listing

The present and future of deep learning in radiology.

Eur J Radiol 2019 May 2;114:14-24. Epub 2019 Mar 2.

Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA. Electronic address:

The advent of Deep Learning (DL) is poised to dramatically change the delivery of healthcare in the near future. Not only has DL profoundly affected the healthcare industry it has also influenced global businesses. Within a span of very few years, advances such as self-driving cars, robots performing jobs that are hazardous to human, and chat bots talking with human operators have proved that DL has already made large impact on our lives. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0720048X193009
Publisher Site
http://dx.doi.org/10.1016/j.ejrad.2019.02.038DOI Listing
May 2019
1 Read

Ranking of stroke and cardiovascular risk factors for an optimal risk calculator design: Logistic regression approach.

Comput Biol Med 2019 Mar 25;108:182-195. Epub 2019 Mar 25.

Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA. Electronic address:

Purpose: Conventional cardiovascular risk factors (CCVRFs) and carotid ultrasound image-based phenotypes (CUSIP) are independently associated with long-term risk of cardiovascular (CV) disease. In this study, 26 cardiovascular risk (CVR) factors which consisted of a combination of CCVRFs and CUSIP together were ranked. Further, an optimal risk calculator using AtheroEdge composite risk score (AECRS1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiomed.2019.03.020DOI Listing
March 2019
1.240 Impact Factor

Cytokine production in allergic and Trichuris trichiura-infected children from an urban region of the Brazilian northeast.

Parasitol Int 2019 Apr 17. Epub 2019 Apr 17.

Immunology Section, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, Brazil. Electronic address:

The relationship between the cellular immune response during Trichuris trichiura infection and asthma has not yet been established. In this study, the cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17A were evaluated in asthmatic children harboring T. trichiura. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parint.2019.04.015DOI Listing

Evaluating laboratory criteria for combined immunodeficiency in adult patients diagnosed with common variable immunodeficiency.

Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Department for Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Some patients diagnosed with common variable immunodeficiency (CVID) actually suffer from combined immunodeficiency (CID) and therefore may require a different, CID-adapted treatment. Several CD4 T-cell-based criteria have been proposed in the past to identify patients with CID within the cohort of adult CVID patients. In this monocentric study, we used retrospective immunological and clinical data of 238 CVID patients to compare four different proposals of how to define CID among CVID patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2019.04.001DOI Listing

Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, China. Electronic address:

Rheumatoid arthritis fibroblast-like synoviocytes play an essential role in the occurrence and progression of rheumatoid arthritis. As the main pharmacologically active components of Aralia taibaiensis, total saponins, particularly triterpenoid saponins, have been shown to possess multiple pharmacological activities including relieving rheumatism. However, the effect of araloside A, a triterpenoid saponin extracted from the root bark of Aralia taibaiensis, on rheumatoid arthritis remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbi.2019.04.025DOI Listing

Lung clearance index for early detection of pulmonary complications after allo-HSCT in children.

Pediatr Pulmonol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Pulmonary chronic graft-vs-host disease (cGvHD) after hematopoietic stem cell transplantation (HSCT) is characterized by impairment of the small airways. Assessment of lung clearance index (LCI) gained from multiple breath washout (MBW) is more sensitive than spirometry in detection of small airways disease. The aim of this study was to describe the development of LCI during the first year after pediatric HSCT and how LCI relates to other pulmonary function parameters and cGvHD. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24340
Publisher Site
http://dx.doi.org/10.1002/ppul.24340DOI Listing
April 2019
2 Reads

Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Nebraska Medical Center, Omaha, NE, USA.

Introduction: Assess the cost-effectiveness (US healthcare payer perspective) of sarilumab subcutaneous (SC) 200 mg + methotrexate versus conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) or targeted DMARD + methotrexate for moderate-to-severe rheumatoid arthritis (RA) in adults with inadequate response to methotrexate.

Methods: Microsimulation based on patient profiles from MOBILITY (NCT01061736) was conducted via a 6-month decision tree and lifetime Markov model with 6-monthly cycles. Treatment response at 6 months was informed by a network meta-analysis and based on American College of Rheumatology (ACR) response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12325-019-00946-1DOI Listing

Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study.

Clin Rheumatol 2019 Apr 19. Epub 2019 Apr 19.

Division of Diagnostic Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objectives: To determine the prevalence of clinical manifestations and incidence rate of cardiopulmonary complications in a comparison between men and women with early SSc.

Methods: An inception cohort of early-SSc patients at the Rheumatology Clinic, Maharaj Nakorn Chiang Mai Hospital, between January 2010 and June 2016, was used. All patients were assessed for clinical manifestations and underwent ECG, echocardiography, and HRCT at the study entry and then annually. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10067-019-04551-zDOI Listing

Possible Molecular Mediators Involved and Mechanistic Insight into Fibromyalgia and Associated Co-morbidities.

Neurochem Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Fibromyalgia is a chronic complex syndrome of non-articulate origin characterized by musculoskeletal pain, painful tender points, sleep problems and co-morbidities including depression, migraine. The etiopathogenesis of fibromyalgia is complex, variable and remains inconclusive. The etiological factors that have been defined include stress, genetic predisposition and environmental components. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11064-019-02805-5
Publisher Site
http://dx.doi.org/10.1007/s11064-019-02805-5DOI Listing
April 2019
1 Read

Pro- and anti-inflammatory eicosanoids in psoriatic arthritis.

Metabolomics 2019 Apr 19;15(4):65. Epub 2019 Apr 19.

Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.

Introduction: Eicosanoids are biological lipids that serve as both activators and suppressors of inflammation. Eicosanoid pathways are implicated in synovitis and joint destruction in inflammatory arthritis, yet they might also have a protective function, underscoring the need for a comprehensive understanding of how eicosanoid pathways might be imbalanced. Until recently, sensitive and scalable methods for detecting and quantifying a high number of eicosanoids have not been available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11306-019-1527-0DOI Listing

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.

Eur Heart J 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, Charité Center 11, Charité-University Medicine Berlin, Hindenburgdamm 30, Berlin, Germany.

Aims: Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging share a complex pathophysiology, including extracellular matrix remodelling (EMR). Protease-activated receptor 2 (PAR2) deficiency is associated with EMR. The roles of PAR1 and PAR2 have not been studied in HFpEF, age-dependent cardiac fibrosis, or diastolic dysfunction (DD). Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/eurheartj/advance-article/doi/10.10
Publisher Site
http://dx.doi.org/10.1093/eurheartj/ehz117DOI Listing
April 2019
1 Read

The effects of fruit consumption in patients with hyperuricaemia or gout.

Rheumatology (Oxford) 2019 Apr 19. Epub 2019 Apr 19.

Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA.

The consumption of fructose has gained increased attention as a potential cause of hyperuricaemia since fructose metabolism produces urate as a byproduct. In addition to sucrose and high fructose corn syrup, fresh fruits also contain fructose, suggesting that patients with hyperuricaemia or gout might also avoid fresh fruit. However, the effect of fruits is complex. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/rheumatology/advance-article/doi/10
Publisher Site
http://dx.doi.org/10.1093/rheumatology/kez128DOI Listing
April 2019
1 Read

Allogeneic hematopoietic cell transplantation improves outcome of adults with t(6;9) acute myeloid leukemia - results from an international collaborative study.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA.

Acute myeloid leukemia with t(6;9)(p22;q34) is a distinct entity accounting for 1-2% of acute myeloid leukemia cases. A substantial proportion of these patients have a concomitant FLT3-ITD. While outcomes are dismal with intensive chemotherapy, limited evidence suggests allogeneic hematopoietic cell transplantation may improve survival if applied early during first complete remission. Read More

View Article

Download full-text PDF

Source
http://www.haematologica.org/lookup/doi/10.3324/haematol.201
Publisher Site
http://dx.doi.org/10.3324/haematol.2018.208678DOI Listing
April 2019
1 Read

The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis.

J Immunol 2019 Apr 19. Epub 2019 Apr 19.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia;

The adult heart contains macrophages derived from both embryonic and adult bone marrow (BM)-derived precursors. This population diversity prompted us to explore how distinct macrophage subsets localize within the heart, and their relative contributions in cardiac disease. In this study, using the reciprocal expression of Lyve-1 and Ccr2 to distinguish macrophages with distinct origins, we show that, in the steady state, both embryonic (Lyve) and BM-derived (Ccr2) macrophages populate the major vessels of the heart in mice and humans. Read More

View Article

Download full-text PDF

Source
http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1900071
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1900071DOI Listing
April 2019
1 Read

Post-translational targeting of a recombinant protein promotes its efficient secretion into the periplasm.

Appl Environ Microbiol 2019 Apr 19. Epub 2019 Apr 19.

Division of Glycoscience, Department of Chemistry, KTH Royal Institute of Technology, AlbaNova University Centre, Stockholm, Sweden

Many recombinant proteins that are produced in have to be targeted to the periplasm to be functional. N-terminal signal peptides can be used to direct recombinant proteins to the membrane embedded Sec-translocon, a multiprotein complex that translocates proteins across the membrane into the periplasm. We have recently shown that the co-translational targeting of the single-chain variable antibody fragment BL1 saturates the capacity of the Sec-translocon leading to impaired translocation of secretory proteins and protein misfolding/aggregation in the cytoplasm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AEM.00671-19DOI Listing

Mindfulness-based cognitive therapy in Korean patients with systemic lupus erythematosus: A pilot study.

Complement Ther Clin Pract 2019 May 16;35:18-21. Epub 2019 Jan 16.

Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea. Electronic address:

Background: and purpose: The stress and systemic lupus erythematosus (SLE) are intertwined and affecting each other. This pilot study evaluated the mindfulness-based cognitive therapy (MBCT) in Korean patients with SLE.

Materials And Methods: The Korean version of the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Satisfaction with Life Scale (SWLS), and Perceived Stress Scale (PSS) were evaluated for the effect of the MBCT in 25 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctcp.2019.01.009DOI Listing

Functional Characterization of Clinically-Relevant Rare Variants in Identified in a Gout and Hyperuricemia Cohort.

Cells 2019 Apr 18;8(4). Epub 2019 Apr 18.

Institute of Rheumatology, 128 50 Prague 2, Czech Republic.

ATP-binding cassette subfamily G member 2 (ABCG2) is a physiologically important urate transporter. Accumulating evidence demonstrates that congenital dysfunction of ABCG2 is an important genetic risk factor in gout and hyperuricemia; recent studies suggest the clinical significance of both common and rare variants of ABCG2. However, the effects of rare variants of on the risk of such diseases are not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8040363DOI Listing

Classroom Furniture Mismatch and Back Pain Among Adolescent School-Children in Abha City, Southwestern Saudi Arabia.

Int J Environ Res Public Health 2019 Apr 18;16(8). Epub 2019 Apr 18.

Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia.

: To explore the potential classroom furniture mismatch with students' anthropometric measurements and back pain related to sitting for extended periods. This cross-sectional study was carried out on all twelve male and female intermediate and secondary schools located in Abha city. Anthropometric and classroom furniture measurements were assessed, and the mismatch was determined using standardized methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16081395DOI Listing

Discoidin domain receptor 2: An emerging pharmacological drug target for prospective therapy against osteoarthritis.

Pharmacol Rep 2019 Jan 15;71(3):399-408. Epub 2019 Jan 15.

Department of Pharmaceutical Sciences, Drug Discovery Research Laboratorty, Assam University, Silchar, Assam, India. Electronic address:

Discoidin domain receptor2 (DDR2), a cell membrane tyrosine kinase on chondrocytes surface plays main role in cell-ECM interaction during the progressive degeneration of articular cartilage in osteoarthritis. The degraded component of ECM, type II collagen upon DDR2 binding provokes synthesis of matrix metalloproteinases (MMPs), responsible for severe destruction of joint tissues. DDR2 knockout has been investigated to decline the expression of MMP-1 and 13. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharep.2019.01.007DOI Listing
January 2019
1 Read

The safety and efficacy of Guluronic acid (G2013) in ankylosing spondylitis: A randomized controlled parallel clinical trial.

Pharmacol Rep 2019 Feb 10;71(3):393-398. Epub 2019 Feb 10.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: To assess the therapeutic efficacy, safety and tolerability of Guluronic acid (G2013) in patients with ankylosing spondylitis (AS) patients.

Methods: This investigation was a 12-week randomized, placebo-controlled, phase I/II clinical trial involving 75 AS patients that were randomly divided into 3 groups: 25 as placebo, 25 Guluronic acid and 25 naproxen groups. Patients who had AS with active disease at baseline according to the modified New York criteria were considered for this trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharep.2019.02.002DOI Listing
February 2019
1 Read

Clinical performance of non-criteria antibodies to phospholipids in Chinese patients with antiphospholipid syndrome.

Clin Chim Acta 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China. Electronic address:

Background: Increasing evidence suggests the role of non-criteria aPLs as important supplements to the current criteria aPLs in APS. In this study, we evaluated the clinical performance of a panel of non-criteria antibodies to phospholipid antigens, including, phosphatidylserine (aPS), phosphatidylinositol (aPI), sphingomyelin (aSM), phosphatidylcholine (aPC) and phosphatidylethanolamine (aPE) in a well-defined Chinese APS cohort.

Methods: A total of 229 subjects were tested, including 86 patients with APS, 104 disease controls (DCs) and 39 healthy controls (HCs). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00098981193181
Publisher Site
http://dx.doi.org/10.1016/j.cca.2019.04.065DOI Listing
April 2019
1 Read

Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis.

PLoS One 2019 19;14(4):e0215333. Epub 2019 Apr 19.

Department of Clinical Microbiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Background: Staphylococcus aureus is the most frequent and fatal cause of left-sided infective endocarditis (IE). New treatment strategies are needed to improve the outcome. S. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215333PLOS

Prevalence and predictors for sustained remission in rheumatoid arthritis.

PLoS One 2019 19;14(4):e0214981. Epub 2019 Apr 19.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.

Objective: Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little is known about the predictors of sustained remission for patients reaching remission. Using two independent cohorts, we aimed to evaluate the prevalence and predictors for sustained remission. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214981PLOS
April 2019
1 Read
3.234 Impact Factor

Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation.

JAMA Netw Open 2019 Apr 5;2(4):e192416. Epub 2019 Apr 5.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Importance: Head-to-head randomized clinical trials showed greater efficacy of denosumab vs alendronate in improving bone mineral density. Although there is an association of changes in bone mineral density with reductions in fracture risk, the magnitude of the association is not well established.

Objective: To compare the risk of hip and any fracture in patients treated with denosumab and alendronate in routine practice settings. Read More

View Article

Download full-text PDF

Source
http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
Publisher Site
http://dx.doi.org/10.1001/jamanetworkopen.2019.2416DOI Listing
April 2019
1 Read

Abatacept alleviates rheumatoid arthritis development by inhibiting migration of fibroblast-like synoviocytes via MAPK pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3105-3111

Department of Rheumatology, Yantaishan Hospital, Yantai, China.

Objective: To investigate whether Abatacept could regulate the occurrence and progression of rheumatoid arthritis (RA) by mediating cell migration of fibroblast-like synoviocytes (FLS) via mitogen-activated protein kinase (MAPK) pathway.

Patients And Methods: Levels of MMP1, MMP3 and MMP13 in RA-FLS treated with Abatacept or MAPK pathway inhibitor were detected by quantitative Real-time-polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The regulatory effect of Abatacept on MAPK pathway was detected by Western blot. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26355/eurrev_201904_17594DOI Listing

Correlation analysis of TLR9 and IL-23 expression in patients with lupus nephritis.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2944-2949

Department of Rheumatology and Immunology, Affiliated Hospital of Jining Medical College, Jining, China.

Objective: The aim of this study was to investigate the expression levels of toll-like receptor 9 (TLR9) and interleukin-23 (IL-23) in renal tissue and serum of patients with lupus nephritis (LN), and to explore their clinical correlation.

Patients And Methods: LN patients and healthy controls were enrolled in the experimental group and the control group, respectively. Blood samples, serum, and peripheral blood mononuclear cells (PBMCs) were collected. Read More

View Article

Download full-text PDF

Source
http://www.europeanreview.org/article/17574
Publisher Site
http://dx.doi.org/10.26355/eurrev_201904_17574DOI Listing
April 2019
1 Read

Erratum zu: A case of Hughes-Stovin syndrome (incomplete Behçet’s disease) with extensive arterial involvement.

Z Rheumatol 2019 Apr 18. Epub 2019 Apr 18.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Enschede, Niederlande.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00393-019-0640-9DOI Listing

Longitudinal Analysis Between Maternal Feeding Practices and Body Mass Index (BMI): A Study in Asian Singaporean Preschoolers.

Front Nutr 2019 2;6:32. Epub 2019 Apr 2.

Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore, Singapore.

Bidirectional studies between maternal feeding practices with subsequent child weight are limited, with no studies in Asian populations. In longitudinal analyses, we assessed the directionality of the associations between maternal feeding practices and body mass index (BMI) in preschoolers. Participants were 428 mother child dyads from the GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fnut.2019.00032/
Publisher Site
http://dx.doi.org/10.3389/fnut.2019.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454195PMC
April 2019
1 Read

Concordance between the Different Cardiovascular Risk Scores in People with Rheumatoid Arthritis and Psoriasis Arthritis.

Cardiol Res Pract 2019 14;2019:7689208. Epub 2019 Mar 14.

Clinical Epidemiology and Biostatistics Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña, Hotel de Pacientes 7 Planta, C/As Xubias de Arriba, 84, 15006 A Coruña, Spain.

Aim: To determine the cardiovascular risk and the concordance between the different scores in people with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).

Methods: Observational descriptive study of prevalence. Performed in the Rheumatology Service and the Clinical Epidemiology and Biostatistics Unit of the University Hospital Complex of A Coruña (Spain). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/7689208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437736PMC

Osteoimmunology of Bone Loss in Inflammatory Rheumatic Diseases.

Front Immunol 2019 3;10:679. Epub 2019 Apr 3.

INSERM, UMR1033 LYOS, Lyon, France.

Over the past two decades, the field of osteoimmunology has emerged in response to a range of evidence demonstrating the reciprocal relationship between the immune system and bone. In particular, localized bone loss, in the form of joint erosions and periarticular osteopenia, as well as systemic osteoporosis, caused by inflammatory rheumatic diseases including rheumatoid arthritis, the prototype of inflammatory arthritis has highlighted the importance of this interplay. Osteoclast-mediated resorption at the interface between synovium and bone is responsible for the joint erosion seen in patients suffering from inflammatory arthritis. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00679
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456657PMC
April 2019
1 Read

Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.

Front Immunol 2019 29;10:659. Epub 2019 Mar 29.

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Feto-maternal microchimerism (FMM) involves bidirectional cross-placental trafficking during pregnancy, leading to a micro-chimeric state that can persist for decades. In this manner a pregnant woman will harbor cells from her mother, as well as, cells from her child. Historically, eclampsia, a severe disorder of pregnancy provided the basis for FMM following the detection of trophoblast cells in the lungs of deceased women. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00659
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455070PMC
March 2019
1 Read

A Path to Prediction of Outcomes in Juvenile Idiopathic Inflammatory Myopathy.

Front Immunol 2019 2;10:638. Epub 2019 Apr 2.

Division of Pediatric Rheumatology, Department of Pediatrics, Duke University, Durham, NC, United States.

Humans have an innate desire to observe and subsequently dissect an event into component pieces in an effort to better characterize the event. We then examine these pieces individually and in combinations using this information to determine the outcome of future similar events and the likelihood of their recurrence. Practically, this attempt to foretell an occurrence and predict its outcomes is evident in multiple disciplines ranging from meteorology to sociologic studies. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00638
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454149PMC
April 2019
1 Read

Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing .

Front Immunol 2019 2;10:578. Epub 2019 Apr 2.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

and both contain risk alleles for systemic lupus erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our group predicts specific endolysosomal-dependent immune responses are driven by the protein products of these genes, which form a complex at the endolysosomal surface. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00578
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454867PMC
April 2019
1 Read

Long-Term Retention Rate of Anakinra in Adult Onset Still's Disease and Predictive Factors for Treatment Response.

Front Pharmacol 2019 2;10:296. Epub 2019 Apr 2.

Research Centre of Systemic Autoinflammatory Diseases, Behçet's Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Centre, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Anakinra (ANA) is an effective treatment choice in patients with adult onset Still's disease (AOSD). Variables affecting treatment survival include loss of efficacy or adverse events, but also the decision to discontinue treatment after long-term clinical remission. Aims of this study were: (i) to assess the drug retention rate (DRR) of ANA during a long-term follow-up looking for any difference related to the line of biologic treatment, the concomitant use of conventional disease modifying anti-rheumatic drugs (cDMARDs) and the different type of AOSD (systemic versus chronic articular); (ii) to identify predictive factors of lack of efficacy, loss of efficacy, and ANA withdrawal owing to long-term remission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454864PMC

Has lupus anticoagulant testing had its day?

Nat Rev Rheumatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41584-019-0218-6DOI Listing

Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke.

Sci Rep 2019 Apr 18;9(1):6283. Epub 2019 Apr 18.

University of Copenhagen, Faculty of Health and Medical Sciences, Department of Odontology, Copenhagen, Denmark.

The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42594-zDOI Listing

Endothelial FAM3A positively regulates post-ischaemic angiogenesis.

EBioMedicine 2019 Apr 15. Epub 2019 Apr 15.

Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background: Angiogenesis improves reperfusion to the ischaemic tissue after vascular obstruction. The underlying molecular mechanisms of post-ischaemic angiogenesis are not clear. FAM3A belongs to the family with sequence similarity 3 (FAM3) genes, but its biological function in endothelial cells in regards to vascular diseases is not well understood. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23523964193017
Publisher Site
http://dx.doi.org/10.1016/j.ebiom.2019.03.038DOI Listing
April 2019
1 Read