18,229 results match your criteria Rheumatoid Spondylitis


Vitamin D-Binding Protein Deficiency and Homozygous Deletion of the Gene.

N Engl J Med 2019 Mar;380(12):1150-1157

From the Departments of Laboratory Medicine (C.M.H., S.L.F., T.J.L., K.J.J., A.N.H.) and Medicine (A.N.H.) and the Kidney Research Institute (A.N.H.), University of Washington, Seattle; and the Department of Endocrinology and Metabolism (H.B.) and the Alberta Children's Hospital Research Institute (B.A.), University of Calgary, and the Division of Medical Genetics, Alberta Children's Hospital (R.L., P.F., J.L.M.), Calgary, and the Department of Pathology, Children's & Women's Health Centre of British Columbia, Vancouver (L.B.) - all in Canada.

A 58-year-old woman with debilitating ankylosing spondylitis who was born to consanguineous parents was found to have an apparent severe vitamin D deficiency that did not respond to supplementation. Liquid chromatography-tandem mass spectrometry showed the absence of circulating vitamin D-binding protein, and chromosomal microarray confirmed a homozygous deletion of the group-specific component () gene that encodes the protein. Congenital absence of vitamin D-binding protein resulted in normocalcemia and a relatively mild disruption of bone metabolism, in this case complicated by severe autoimmune disease. Read More

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http://dx.doi.org/10.1056/NEJMoa1807841DOI Listing

The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes.

Int J Immunogenet 2019 Mar 20. Epub 2019 Mar 20.

Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.

LILR and KIR receptors recognize HLA-B27 and may influence immune response in ankylosing spondylitis (AS) development. Purpose of the study was to analyse LILRB1/LILRA3 polymorphisms in AS. We observed a possible protective effect of the T allele of LILRB1 rs1061680:T>C and no association with insertion/deletion polymorphisms of LILRA3 with AS. Read More

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http://dx.doi.org/10.1111/iji.12422DOI Listing

Challenging Management of Hepatitis B infection in Ankylosing Spondylitis Patients in an Endemic Area during Immunosuppressive Therapy.

Rev Soc Bras Med Trop 2019 Mar 18;52:e20180386. Epub 2019 Mar 18.

Departamento de Clínica Médica, Residência de Reumatologia, Faculdade de Medicina, Universidade Federal do Amazonas, Amazonas, Brasil.

Hepatitis B infection is a global health issue. When considering patients with rheumatic diseases, this is no different. By using immunosuppressant drugs, such as DMARDs and biologics, viral reactivation is possible, leading to serious consequences on the patient. Read More

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http://dx.doi.org/10.1590/0037-8682-0386-2018DOI Listing

Challenges in the Diagnosis and Management of Spinal Tuberculosis: Case Series.

Cureus 2019 Jan 8;11(1):e3855. Epub 2019 Jan 8.

Orthopaedics, Syracuse Veterans Affairs Hospital, Syracuse, USA.

Though uncommon in developed countries, spinal tuberculosis must still be considered in patients with a suspicious clinical history, to avoid delays in treatment. This case series highlights the special considerations that need to be taken into account while tackling the diagnostic and therapeutic challenges associated with this disease. We present two interesting cases of spinal tuberculosis. Read More

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http://dx.doi.org/10.7759/cureus.3855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411342PMC
January 2019

Prefoldin 5 and Anti-prefoldin 5 Antibodies as Biomarkers for Uveitis in Ankylosing Spondylitis.

Front Immunol 2019 5;10:384. Epub 2019 Mar 5.

Division of Rheumatology, Department of Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea.

Uveitis is the most common extra-articular manifestation of ankylosing spondylitis (AS), for which no diagnostic biomarkers have been identified. This study was conducted to identify biomarker for uveitis in AS. To identify autoantibodies associated with uveitis in AS, we performed human protein microarray analysis using sera derived from various autoimmune diseases and ELISA analysis of sera derived from AS and rheumatoid arthritis patients. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411661PMC

Is Routine MRI of the Spine Necessary in Trauma Patients with Ankylosing Spinal Disorders or is a CT Scan Sufficient?

Spine J 2019 Mar 16. Epub 2019 Mar 16.

Department of Orthopaedics and Sport Medicine, Harborview Medical Center, 325 Ninth Avenue Seattle, WA 98104, USA. Electronic address:

Background: Ankylosing spinal disorder (ASD) patients are at a greater risk for spinal fractures due to osteoporosis and rigidity of the spinal column. These fractures are associated with a high risk of neurologic compromise resulting from delayed or missed diagnoses. Although CT is usually the initial imaging modality, MRI has been proposed as mandatory to help identify spinal injuries in ASD patients with unexplained neck or back pain or known injuries to help identify non-contiguous fractures. Read More

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http://dx.doi.org/10.1016/j.spinee.2019.03.004DOI Listing

Perioperative medical management for patients with RA, SPA, and SLE undergoing total hip and total knee replacement: a narrative review.

BMC Rheumatol 2018 30;2. Epub 2018 Jan 30.

Department of Medicine, Weill Cornell Medical School, Division of Rheumatology Hospital for Special Surgery, 535 E 70th St, New York City, NY 10021 USA.

Total hip (THA) and total knee arthroplasty (TKA) are widely used, successful procedures for symptomatic end stage arthritis of the hips or knees, but patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and spondyloarthritis (SPA) including ankylosing spondylitis (AS) and psoriatic arthritis (PSA) are at higher risk for adverse events after surgery. Utilization rates of THA and TKA remain high for patients with RA, and rates of arthroplasty have increased for patients with SLE and SPA. However, complications such as infection are increased for patients with SLE, RA, and SPA, most of whom are receiving potent immunosuppressant medications and glucocorticoids at the time of surgery. Read More

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http://dx.doi.org/10.1186/s41927-018-0008-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390575PMC
January 2018

Structural damage and motion rhythm of the spine and hip during trunk lateral bending in ankylosing spondylitis patients with mild to moderate radiographic signs.

Clin Biomech (Bristol, Avon) 2019 Feb 23;63:112-118. Epub 2019 Feb 23.

Department of Microbiology & Immunology of National Cheng Kung University, Tainan, Taiwan, ROC.

Background: Ankylosing spondylitis causes structural damage and motion restriction in spine. The study was designed to assess structural damage and incoordination pattern between the spine and hip during trunk lateral bending in ankylosing spondylitis.

Methods: Twenty-three healthy adults and 39 adults with ankylosing spondylitis were recruited from a tertiary care medical centre. Read More

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http://dx.doi.org/10.1016/j.clinbiomech.2019.02.013DOI Listing
February 2019

DNA methylation and transcriptome signature of the IL12B gene in ankylosing spondylitis.

Int Immunopharmacol 2019 Mar 16;71:109-114. Epub 2019 Mar 16.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address:

Objective: Ankylosing spondylitis (AS) is an autoimmune disease without a reliable biomarker. This study investigated the IL12B gene methylation as a robust marker by integrating DNA methylation and mRNA data.

Methods: A two-stage design was used for methylome and transcriptome investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193006
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http://dx.doi.org/10.1016/j.intimp.2019.03.026DOI Listing
March 2019
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Prevalence of chronic widespread pain in a population-based cohort of patients with spondyloarthritis - a cross-sectional study.

BMC Rheumatol 2018 5;2:11. Epub 2018 Apr 5.

2Department of Clinical Sciences Lund,Rheumatology, Lund University, Faculty of Medicine, Lund, Sweden.

Background: Chronic pain, regional or widespread, is a frequent and multidimensional symptom in arthritis. There is still limited information on chronic pain in spondyloarthritis, which is important to recognize for adequate diagnosis and treatment. Our objective was to study differences in prevalence of chronic widespread pain in two spondyloarthritis subgroups: ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (USpA). Read More

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http://dx.doi.org/10.1186/s41927-018-0018-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390534PMC

Rifaximin Alters Intestinal Microbiota and Prevents Progression of Ankylosing Spondylitis in Mice.

Front Cell Infect Microbiol 2019 4;9:44. Epub 2019 Mar 4.

Department of Orthopedic Surgery, Orthopaedic Hospital of Guangdong Province, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.

Recently, accumulating evidence has suggested that gut microbiota may be involved in the occurrence and development of ankylosing spondylitis (AS). It has been suggested that rifaximin have the ability to modulate the gut bacterial communities, prevent inflammatory response, and modulate gut barrier function. The goal of this work is to evaluate the protective effects of rifaximin in fighting AS and to elucidate the potential underlying mechanism. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409347PMC

Can the Second to Fourth Digit Ratio (2D : 4D) Be a Marker to Determine Ankylosing Spondylitis Disease Activity?

Dis Markers 2019 11;2019:4612370. Epub 2019 Feb 11.

Department of Rheumatology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Objective: The length ratio of the index finger (2D) to the ring finger (4D) (2D : 4D ratio) is considered a biomarker of prenatal sex hormone exposure. The 2D : 4D ratio is influenced by prenatal androgen and estrogen levels. Because ankylosing spondylitis (AS) influences men more frequently and severely than women, androgens are proposed to be related to AS pathogenesis. Read More

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http://dx.doi.org/10.1155/2019/4612370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388325PMC
February 2019

[Short term effect of total hip arthroplasty through direct anterior approach for the treatment of ankylosing spondylitis with hip flexion deformity].

Zhongguo Gu Shang 2019 Feb;32(2):141-145

Department of Orthopaedics, the Second Affiliated Hospital of Bengbu Medical College, Bengbu 233040, Anhui, China;

Objective: To investigate the short term clinical efficacy of direct anterior approach(DAA) total hip arthroplasty for the treatment of ankylosing spondylitis with hip flexion deformity.

Methods: From September 2014 to June 2017, 15 cases of ankylosing spondylitis with flexion deformity of the hip were treated with total hip arthroplasty through DAA approach including 12 males(17 hips) and 3 females(4 hips) with an average age of 34.4 years old ranging from 21 to 57 years old. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.02.009DOI Listing
February 2019

A quick decrease of bone marrow edema in sacroiliac joint could be served as a novel marker for dose tapering of etanercept in ankylosing spondylitis patients.

Medicine (Baltimore) 2019 Mar;98(11):e14620

Department of Orthopaedic Surgery, The Second People's Hospital of Liaocheng, Linqing, Shandong, China.

The purpose of this study was to investigate the correlation of bone marrow edema (BME) in sacroiliac joint (SIJ) with clinical characteristics and clinical response, and whether the quick decrease of BME could be served as a novel marker for dose tapering of etanercept in ankylosing spondylitis (AS) patients.Ninety active AS patients underwent etanercept treatment for 6 months were enrolled consecutively and classified into standard dose group (n = 37) and dose tapering group (n = 53). BME in SIJ and clinical response were assessed by SPARCC criteria and ASAS 40 response criteria, respectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000014620DOI Listing

Measuring spinal mobility in early axial spondyloarthritis: does it matter?

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To investigate the frequency and order of impairment of spinal mobility measures (SMMs) and their cross-sectional and longitudinal usefulness in early axial spondyloarthritis.

Methods: SMMs measurements of patients from the DESIR (5-year data) and SPACE (2.6 (1. Read More

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http://dx.doi.org/10.1093/rheumatology/kez026DOI Listing

Unmet needs in the treatment of ankylosing spondylitis: a long-term observational study from a single university center.

Rheumatol Int 2019 Mar 15. Epub 2019 Mar 15.

Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.

Despite the progress in the treatment of ankylosing spondylitis (AS), a significant number of patients do not achieve low disease activity (LDA). The aim of the study is to estimate the size of unmet needs in the treatment of AS in a long-term observational study. Between January 2003 and December 2017, 220 patients with radiographic SpA were evaluated fulfilling the ASAS criteria. Read More

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http://dx.doi.org/10.1007/s00296-019-04277-wDOI Listing
March 2019
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Rheumatologists use different cut offs for disease activity in real life - the experience with Golimumab in ankylosing spondylitis - Subanalysis from the Non-Interventional German GO-NICE study.

J Rheumatol 2019 Mar 15. Epub 2019 Mar 15.

From the Rheumazentrum Ruhrgebiet, Herne and Ruhr University Bochum, Germany; Rheumatologisches Praxiszentrum, München; Department of Rheumatology and Clinical Immunology, Charité- Universitätsmedizin, Berlin; Rheumazentrum Ratingen, Ratingen; Medical Affairs, MSD Sharp & Dohme GmbH, Haar, Germany. Address correspondence to Prof. Dr. med. Jürgen Braun Rheumazentrum Ruhrgebiet Ruhr-University Bochum Claudiusstr. 45 D-44649 Herne. E-Mail:

Objective: International recommendations for the management of axial spondyloarthritis including ankylosing spondylitis (AS) recommend a BASDAI level of disease activity of ≥4 to initiate treatment with biologics. We aimed to evaluate the level of disease activity used to initiate tumor necrosis factor inhibitor (TNFi) treatment and the level of responses to treatment based on different BASDAI cut-offs.

Methods: This is a posthoc analysis of the non-interventional, prospective, GO-NICE study in the subgroup of biologic-naïve AS treated with golimumab 50mg subcutaneously once monthly. Read More

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http://dx.doi.org/10.3899/jrheum.181040DOI Listing
March 2019
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Useful message in choosing optimal biological agents for patients with autoimmune arthritis.

Biochem Pharmacol 2019 Mar 12. Epub 2019 Mar 12.

Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, ROC. Electronic address:

The introduction of biological disease-modifying antirheumatic drug (bDMARD) treatments for various types of autoimmune arthritis, such as rheumatoid arthritis, psoriatic arthropathy and ankylosing spondylitis, represents a new era of treatment for patients with a refractory response to conventional synthetic DMARDs (csDMARDs). Many new bDMARDs with different modalities or that target different pro-inflammatory molecules, likely cytokines, are rapidly emerging. Hence, physicians in the field may be confused about choosing appropriate bDMARDs for their patients. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.03.007DOI Listing
March 2019
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Does relocation of the apex after osteotomy affect surgical and clinical outcomes in patients with ankylosing spondylitis and thoracolumbar kyphosis?

J Neurosurg Spine 2019 Mar 15:1-8. Epub 2019 Mar 15.

OBJECTIVERelocation of the apex is often found in patients with ankylosing spondylitis (AS)-associated thoracolumbar/lumbar kyphosis after corrective surgery. This study evaluates the influence of different postoperative apex locations on surgical and clinical outcomes of osteotomy for patients with AS and thoracolumbar kyphosis.METHODSSixty-two patients with a mean age of 34. Read More

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http://dx.doi.org/10.3171/2018.12.SPINE18752DOI Listing
March 2019
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[Medical care situation of patients with ankylosing spondylitis and psoriatic arthritis in Germany : Medical care situation of patients with spondyloarthritis (SpA): ankylosing spondylitis (AS) and psoriatic arthritis (PsA) from the perspective of rheumatologists in private practice and hospitals in Germany-Results of the research project "SpA Loop-Life of Outpatients"].

Z Rheumatol 2019 Mar 15. Epub 2019 Mar 15.

CIRI/Rheumatologie & Fraunhofer IME-Translationale Medizin und Pharmakologie, Goethe-Universität, Frankfurt am Main, Deutschland.

Background: The prevalence of spondyloarthritis (SpA) in Germany is approximately 1-1.4% and includes predominantly axial SpA (axSpA) and predominantly peripheral SpA. Ankylosing spondylitis (AS) belongs to the group of axial SpA but also exhibits peripheral manifestations. Read More

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http://dx.doi.org/10.1007/s00393-019-0619-6DOI Listing
March 2019
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Turkish Version of Evaluation of Ankylosing Spondylitis Quality of Life Questionnaire in Patients With Ankylosing Spondylitis: A Validation and Reliability Study.

Arch Rheumatol 2018 Dec 11;33(4):443-454. Epub 2018 Apr 11.

Objectives: This study aims to translate the Evaluation of Ankylosing Spondylitis Quality of Life (EASi-QoL) into the Turkish language and test its validity and reliability.

Patients And Methods: A total of 100 AS patients (74 males; 26 females; mean age 38.2±9. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2018.6614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409161PMC
December 2018
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The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study.

Nutrients 2019 Mar 12;11(3). Epub 2019 Mar 12.

NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, LS7 4SA Leeds, UK.

Intermittent circadian fasting, namely Ramadan, is a common worldwide practice. Such fasting has a positive impact on psoriasis, but no data exist on its role in psoriatic arthritis (PsA)-a disease that is clearly linked to body mass index. We enrolled 37 patients (23 females and 14 males) with a mean age 43. Read More

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http://dx.doi.org/10.3390/nu11030601DOI Listing
March 2019
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Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach.

J Clin Med 2019 Mar 12;8(3). Epub 2019 Mar 12.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea.

The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. This work examined their validity to discover false positive results under Bayesian methods. Read More

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https://www.mdpi.com/2077-0383/8/3/347
Publisher Site
http://dx.doi.org/10.3390/jcm8030347DOI Listing
March 2019
3 Reads

Magnetic resonance imaging of the sacroiliac joints in SpA: with or without intravenous contrast media? A preliminary report.

Radiol Med 2019 Mar 13. Epub 2019 Mar 13.

Department of Medical, Surgical and Neuro Sciences, Diagnostic Imaging, University of Siena, Azienda Ospedaliera Universitaria Senese, Viale Bracci 10, 53100, Siena, Italy.

Object: Active sacroiliitis based on magnetic resonance imaging (MRI) without intravenous (I.V.) contrast material injection is considered sufficient for the diagnosis of spondyloarthritis (SpA), according to the Assessment of SpondyloArthritis International Society (ASAS) criteria. Read More

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http://dx.doi.org/10.1007/s11547-019-01016-wDOI Listing
March 2019
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The European Map of Axial Spondyloarthritis: Capturing the Patient Perspective-an Analysis of 2846 Patients Across 13 Countries.

Curr Rheumatol Rep 2019 Mar 12;21(5):19. Epub 2019 Mar 12.

IdiPaz, Hospital Universitario La Paz, Madrid, Spain.

Purpose Of Review: Scientific research in axial spondyloarthritis (axSpA) has grown significantly. Nevertheless, the patient perspective remains insufficiently explored. Using a cross-sectional survey, the European Map of Axial Spondyloarthritis (EMAS) describes how patients living with self-reported axSpA experience their disease physically, psychologically, and socially. Read More

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http://dx.doi.org/10.1007/s11926-019-0819-8DOI Listing
March 2019
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The Effect of TNF Inhibition on Bone Density and Fracture Risk and of IL17 Inhibition on Radiographic Progression and Bone Density in Patients with Axial Spondyloarthritis: a Systematic Literature Review.

Curr Rheumatol Rep 2019 Mar 12;21(5):20. Epub 2019 Mar 12.

Department of Rheumatology, Hospital for Special Surgery Hospital for Special Surgery, Weill- Cornell Medical School, 535 East 70th Street, New York, NY, 10021, USA.

Purpose Of Review: Osteoporosis in axial spondyloarthritis may be modified by therapy. The purpose of this systematic review is to describe (i) the effect of TNFi on BMD, (ii) the effect of secukinumab on BMD, and (iii) the effect of secukinumab on radiographic disease progression in axSpA.

Recent Findings: We searched PubMed, Embase, and Cochrane using the following retrieval languages: spondyloarthritis, ankylosing spondylitis, TNF, IL-17, x-rays, and osteoporosis. Read More

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http://dx.doi.org/10.1007/s11926-019-0818-9DOI Listing
March 2019
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Correction to: Secukinumab: A Review in Ankylosing Spondylitis.

Authors:
Hannah A Blair

Drugs 2019 Mar;79(4):445

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

The article Secukinumab: A Review in Ankylosing Spondylitis, written by Hannah A. Blair, was originally published Online First without open access. After online publication Novartis Pharma AG requested that the article be Open Choice to make the article an open access publication. Read More

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http://dx.doi.org/10.1007/s40265-019-01089-xDOI Listing
March 2019
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Cost-effectiveness of secukinumab compared to other biologics in the treatment of ankylosing spondylitis in Finland.

Clinicoecon Outcomes Res 2019 15;11:159-168. Epub 2019 Feb 15.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

Aim: This study assesses the cost-effectiveness of secukinumab vs currently licensed biologics for the treatment of ankylosing spondylitis (AS) from the Finnish health care system perspective.

Methods: A semi-Markov model compared secukinumab with adalimumab, adalimumab biosimilar, certolizumab pegol, etanercept, etanercept biosimilar, golimumab, and infliximab in a biologic-naïve population over a lifetime horizon. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was used to assess the treatment response. Read More

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http://dx.doi.org/10.2147/CEOR.S192235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386207PMC
February 2019
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Serum chitotriosidase and neopterin levels in patients with ankylosing spondylitis.

Ther Adv Musculoskelet Dis 2019 1;11:1759720X19832321. Epub 2019 Mar 1.

University of Health Sciences, Gülhane School of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkey.

Background: The aim of this study was to assess the serum chitotriosidase (ChT) and neopterin levels in patients with ankylosing spondylitis (AS) and to evaluate whether serum ChT and neopterin levels are related to disease activity.

Methods: A total of 86 patients with AS were included in the study. Patients were divided into two groups based on Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores: The active AS patients group included 40 patients who had a BASDAI score ⩾4. Read More

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http://dx.doi.org/10.1177/1759720X19832321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399755PMC
March 2019
1 Read

Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain.

Biochem Biophys Res Commun 2019 Mar 5. Epub 2019 Mar 5.

Department of Immunochemistry, Research Institute for Microbial Disease, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Laboratory of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address:

HLA class I molecules play a central role in the immune system by presenting peptide antigens to cytotoxic T cells. Although most HLA class I molecules are associated with β2-microglobulin, HLA class I heavy chain that is not associated with β2-microglobulin is also expressed on certain cells. We recently found that cellular misfolded proteins are transported to the cell surface by HLA class II molecules via association with their peptide-binding grooves. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.120DOI Listing
March 2019
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A 52-Week Randomized Placebo-Controlled Trial of Certolizumab Pegol in Non-Radiographic Axial Spondyloarthritis.

Arthritis Rheumatol 2019 Mar 8. Epub 2019 Mar 8.

Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.

Background: The natural history of non-radiographic axial spondyloarthritis (nr-axSpA) is incompletely characterized, and there are concerns that non-steroidal anti-inflammatory drugs (NSAIDs) provide inadequate disease control in patients with active disease. C-axSpAnd (NCT02552212), the longest placebo-controlled trial in nr-axSpA to date, investigated effects of certolizumab pegol (CZP), an anti-TNF therapy, in nr-axSpA patients with objective signs of inflammation.

Methods: In this ongoing, parallel-group, double-blind study, adults with active disease were recruited from 80 centers in Australia, Europe, North America, and Taiwan, and were randomized 1:1 to placebo or CZP (400mg at Weeks [Wks] 0, 2, and 4 followed by 200mg every 2 wks) in addition to non-biologic background medication [NBBM]). Read More

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http://dx.doi.org/10.1002/art.40866DOI Listing
March 2019
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GC-MS-based fecal metabolomics reveals gender-attributed fecal signatures in ankylosing spondylitis.

Sci Rep 2019 Mar 7;9(1):3872. Epub 2019 Mar 7.

Institute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Ankylosing spondylitis (AS) has different clinical features in males and females. Fecal metabolites play significant roles in AS disorders. This study aimed to reveal gender-attributed fecal signatures of AS. Read More

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http://dx.doi.org/10.1038/s41598-019-40351-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405849PMC
March 2019
2 Reads

Effects of multidisplinary team based nurse-led transitional care on clinical outcomes and quality of life in patients with ankylosing spondylitis.

Asian Nurs Res (Korean Soc Nurs Sci) 2019 Mar 4. Epub 2019 Mar 4.

Department of Nursing, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

Purpose: To investigate the impact of transitional care by a nurse-led multidisciplinary team on clinical outcomes and quality of life of patients with ankylosing spondylitis.

Methods: A randomized control study design was used. Subjects were allocated randomly to an experimental group and a control group. Read More

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http://dx.doi.org/10.1016/j.anr.2019.02.004DOI Listing
March 2019
3 Reads

Elevated expression of interleukin-37 in patients with rheumatoid arthritis.

Int J Rheum Dis 2019 Mar 6. Epub 2019 Mar 6.

Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, Luzhou, Sichuan, China.

Aim: This study aims to discuss plasma and messenger RNA (mRNA) levels of interleukin (IL)-37 in rheumatoid arthritis (RA) patients and evaluate the potential of plasma IL-37 as a biomarker for RA.

Method: Plasma IL-37 levels and IL-37 mRNA relative concentrations were measured by enzyme-linked immunosorbent assay (ELISA) and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). We discussed the association of IL-37 levels and clinical, laboratory parameters in RA patients in a training cohort. Read More

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http://dx.doi.org/10.1111/1756-185X.13539DOI Listing
March 2019
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Association of Congestive Heart Failure and Death with Ankylosing Spondylitis : A Nationwide Longitudinal Cohort Study in Korea.

J Korean Neurosurg Soc 2019 Mar 27;62(2):217-224. Epub 2019 Feb 27.

Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Objective: We attempted to discover that Ankylosing spondylitis (AS) has a comprehensive relationship with congestive heart failure and death.

Methods: We used a nationwide database managed by the Korean National Health Insurance Service from 2010 to 2014. Twelve thousand nine hundred eighty-eight patients with a diagnosis of AS and 64940 age- and sex- stratified matching subjects without AS were enrolled in the AS and control groups. Read More

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http://dx.doi.org/10.3340/jkns.2018.0110DOI Listing
March 2019
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Efficacy and safety of adalimumab in Japanese patients with psoriatic arthritis and inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs): A prospective, observational study.

Mod Rheumatol 2019 Mar 5:1-23. Epub 2019 Mar 5.

f Department of Dermatology and Plastic Surgery, Faculty of Life Sciences , Kumamoto University , Kumamoto , Japan.

Objective: To evaluate the efficacy and safety of adalimumab in psoriatic arthritis (PsA) patients in Japan.

Methods: In this open-label, single-arm study conducted at six sites from October 2014 to June 2016 (UMIN000016543), PsA patients (≥20 years old) with inadequate response to nonsteroidal anti-inflammatory drugs received adalimumab subcutaneously (80 mg initially, then 40 mg every other week; 24 weeks total). Primary endpoint was American College of Rheumatology 20% improvement (ACR20) response rate at week 12. Read More

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http://dx.doi.org/10.1080/14397595.2019.1589739DOI Listing
March 2019
2 Reads

Patients with rheumatic diseases share similar patterns of healthcare resource utilization.

Scand J Rheumatol 2019 Mar 5:1-8. Epub 2019 Mar 5.

g Department of Medicine , Jyväskylä Central Hospital , Jyväskylä , Finland.

Objectives: Healthcare service needs have changed with the use of effective treatment strategies. Using data from the modern era, we aimed to explore and compare health service-related direct costs in juvenile idiopathic arthritis (JIA), psoriatic arthritis (PsA), rheumatoid arthritis (RA), and axial spondyloarthritis (AxSpA).

Methods: We linked a longitudinal, population-based clinical data set from Finland's largest non-university hospital's rheumatology clinic with an administrative database on health service-related direct costs in 2014. Read More

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http://dx.doi.org/10.1080/03009742.2018.1559878DOI Listing
March 2019
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Persistence, Discontinuation, and Switching Patterns of Newly Initiated TNF Inhibitor Therapy in Ankylosing Spondylitis Patients in the United States.

Rheumatol Ther 2019 Mar 5. Epub 2019 Mar 5.

Oregon Health and Science University, Portland, OR, USA.

Introduction: The primary goals of treating ankylosing spondylitis (AS) patients are to maximize long-term health-related quality of life through control of symptoms and inflammation, prevention of progressive structural damage, and preservation of function. The objective of this study was to describe treatment patterns (persistence, discontinuations, and switch) in the 2 years following the initiation of tumor necrosis factor inhibitors (TNFi) therapy in AS patients.

Methods: Adult patients with ≥ 2 AS diagnostic codes (ICD-9: 720. Read More

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http://dx.doi.org/10.1007/s40744-019-0148-4DOI Listing
March 2019
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Olfactory dysfunction in spondyloarthritis.

Eur Arch Otorhinolaryngol 2019 Mar 5. Epub 2019 Mar 5.

Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.

Objective: Spondyloarthritis (SpA) is a group of disorders characterized by inflammatory arthritis including ankylosing spondylitis, psoriatic arthritis, reactive arthritis and arthritis-related inflammatory bowel diseases. Recently it has been shown that arthritic disorders are accompanied by olfactory dysfunction. We aimed to specifically investigate the association between spondyloarthritis and olfactory impairment. Read More

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http://dx.doi.org/10.1007/s00405-019-05364-1DOI Listing
March 2019
2 Reads
1.608 Impact Factor

Added value of biomarkers compared with clinical parameters for the prediction of radiographic spinal progression in axial spondyloarthritis.

Rheumatology (Oxford) 2019 Mar 4. Epub 2019 Mar 4.

Department of Gastroenterology, Infectiology and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany.

Objectives: The objective of this study was to examine whether adding biomarkers to routine clinical parameters improves prediction of radiographic spinal progression in axial spondyloarthritis.

Methods: One hundred and seventeen patients with ankylosing spondylitis who completed the Effects of NSAIDs on RAdiographic Damage in Ankylosing Spondylitis (ENRADAS) trial were included. Radiographic spinal progression was defined as worsening of the modified Stoke Ankylosing Spondylitis Spine Score by ⩾2 points after 2 years. Read More

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http://dx.doi.org/10.1093/rheumatology/kez025DOI Listing
March 2019
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Etiological and Clinical Characteristics of HLA-B27-associated Uveitis in a Tertiary Referral Center

Turk J Ophthalmol 2019 Feb;49(1):10-14

Ulucanlar Eye Training and Research Hospital, Ophthalmology Clinic, Ankara, Turkey

Objectives: To investigate the demographic, etiologic, and clinical features of HLA-B27-associated uveitis.

Materials And Methods: The clinical records of 91 patients diagnosed with HLA-B27-associated uveitis at the Ulucanlar Eye Training and Research Hospital between the years of 2005 and 2016 were reviewed. Each patient’s presenting complaints, best-corrected visual acuities in first and last visits, biomicroscopic and fundoscopic examination findings, frequency and seasonal distribution of attacks, and demographic data such as age and sex were noted. Read More

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http://dx.doi.org/10.4274/tjo.galenos.2018.53896DOI Listing
February 2019
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Micro-RNAs in inflammatory arthritis: From physiopathology to diagnosis, prognosis and therapeutic opportunities.

Biochem Pharmacol 2019 Feb 27. Epub 2019 Feb 27.

Rheumatology Department, Nantes University Hospital, Nantes, France; INSERM UMR 1238, Nantes Faculty of Medicine, France.

Micro-RNAs are an area of research exponentially expanding over the past years. These small sequences of 20-22 nucleotides have a strong role as post-transcriptional regulators of gene expression. Inflammatory arthritis pathophysiology involves various key players from innate to adaptive immunity, as well as various signalling pathways of inflammation. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.031DOI Listing
February 2019
3 Reads

Etiology of Pseudarthrosis in Ankylosing Spondylitis: What Is the Main Cause?

J Rheumatol 2019 Mar;46(3):226-228

Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.

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http://dx.doi.org/10.3899/jrheum.180987DOI Listing
March 2019
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Safety and efficacy of intravenous golimumab in adults with ankylosing spondylitis: Results through 1 year of the GO-ALIVE study.

J Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

From the University of Texas McGovern Medical School, Houston, TX, USA; Oregon Health & Science University, Portland, OR, USA; Arizona Arthritis and Rheumatology Associates, Phoenix, AZ, USA; AMED Medical Center, Warsaw, Poland; Janssen Research & Development, LLC, Spring House, PA, USA; University of Pennsylvania, Philadelphia, PA, USA. Funding: This study was funded by Janssen Research & Development, LLC. Drs. Caldron, and Dudek served as trial investigators for Janssen; Dr. Reveille has received consultancies from Eli Lilly, Janssen, Novartis, Pfizer, and UCB and has served as a trial investigator for Janssen and Eli Lilly; Dr. Deodhar has received consultancies, speaking fees, and/or honoraria from AbbVie, BMS, Eli Lilly, Janssen, Novartis, Pfizer, and UCB; Drs. Harrison, Hsia, Kim, Lo, and Leu are or were employees of Janssen Research & Development, LLC at the time this work was performed, and own stock in Johnson & Johnson, of which Janssen Research & Development, LLC, is a wholly owned subsidiary. Address correspondence to: Elizabeth C Hsia, MD, MSCE Janssen Research & Development, LLC. 1400 McKean Rd PO Box 776 Spring House, PA 19477, E-mail:

Objective: Evaluate safety and efficacy of intravenous golimumab in patients with active ankylosing spondylitis (AS) through 1 year.

Methods: A total of 208 patients were randomized to intravenous infusions of golimumab 2mg/kg (n=105) at weeks 0, 4, and every 8 weeks thereafter or placebo (n=103) at weeks 0, 4, and 12 and golimumab at weeks 16, 20, and every 8 weeks thereafter through week 52. Efficacy was assessed using the Assessment of Spondyloarthritis International Society (ASAS) criteria, Ankylosing Spondylitis Disease Activity Score (ASDAS), and Bath AS Disease Activity Index (BASDAI), and Bath AS Functional Index (BASFI). Read More

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http://dx.doi.org/10.3899/jrheum.180718DOI Listing
March 2019
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Epidemiology of Macular Edema in Uveitis.

Ocul Immunol Inflamm 2019 Mar 1:1-12. Epub 2019 Mar 1.

d IRCCS - Fondazione Bietti , Rome , Italy.

Purpose: To describe the epidemiology of macular edema (ME) in patients with uveitis.

Methods: Review of articles listed on PubMed pertaining to uveitic ME.

Results: Reported rates of uveitic ME ranging from 20% to 70%, depending on the ancillary tests used (fundus examination, fluorescein angiography, optical coherence tomography). Read More

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http://dx.doi.org/10.1080/09273948.2019.1576910DOI Listing
March 2019
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Assessment of Ocular Surface in Patients With Ankylosing Spondylitis.

Eye Contact Lens 2019 Feb 26. Epub 2019 Feb 26.

Ophthalmology Department (R.O., H.B.T., G.S., and M.K.G.), Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey; and Pathology Department (P.O. and N.T.), Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Purpose: To evaluate the clinical findings and ocular surface changes in patients with ankylosing spondylitis (AS).

Methods: This prospective study involved 45 patients with AS (group 1) and 28 healthy subjects (group 2). Patients in group 1 were in the inactive period. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000592DOI Listing
February 2019
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2018 APLAR axial spondyloarthritis treatment recommendations.

Int J Rheum Dis 2019 Mar 28;22(3):340-356. Epub 2019 Feb 28.

Division of Rheumatology and Clinical Immunology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.

Introduction: Despite the availability of axial spondyloarthritis (SpA) recommendations proposed by various rheumatology societies, we considered that a region-specific guideline was of substantial added value to clinicians of the Asia-Pacific region, given the wide variations in predisposition to infections and other patient factors, local practice patterns, and access to treatment across countries.

Materials And Methods: Systematic reviews were undertaken of English-language articles published between 2000 and 2016, identified from MEDLINE using PubMed, EMBASE and Cochrane databases. The strength of available evidence was graded using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Read More

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http://dx.doi.org/10.1111/1756-185X.13510DOI Listing
March 2019
2 Reads

Inhibition of CXCR4 inhibits the proliferation and osteogenic potential of fibroblasts from ankylosing spondylitis via the Wnt/β‑catenin pathway.

Mol Med Rep 2019 Feb 22. Epub 2019 Feb 22.

Department of Orthopedics, Changhai Hospital Affiliated to The Second Military Medical University, Shanghai 200433, P.R. China.

Ankylosing spondylitis (AS) is an autoimmune condition characterized by chronic inflammation and abnormal ossification as the primary features of the disease. The aim of the present study was to investigate the role of C‑X‑C chemokine receptor type 4 (CXCR4) in ossification from patients with AS. CXCR4 expression was assessed by western blot analysis and immunohistochemistry analysis of tissues obtained from patients with AS and controls. Read More

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http://dx.doi.org/10.3892/mmr.2019.9980DOI Listing
February 2019
3 Reads

Reliability and Validity of Turkish Version of Short Form of the Social Role Participation Questionnaire in Patients With Ankylosing Spondylitis.

Arch Rheumatol 2018 Dec 11;33(4):408-417. Epub 2018 Apr 11.

Department of Physical Therapy and Rehabilitation, Medicine Faculty of Ondokuz Mayıs University, Samsun, Turkey.

Objectives: This study aims to evaluate the reliability and validity of the Turkish version of the Short Form of the Social Role Participation Questionnaire (s-SRPQ) in Turkish patients with ankylosing spondylitis.

Patients And Methods: The Turkish version of s-SRPQ questionnaire was obtained after a translation and back translation process. The study sample included 100 ankylosing spondylitis patients (59 males, 41 females; mean age 42. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2018.6756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386251PMC
December 2018
1 Read

Adult outcome of juvenile idiopathic arthritis: A nationwide population-based retrospective cohort study in Taiwan.

Int J Rheum Dis 2019 Feb 27. Epub 2019 Feb 27.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Objective: To clarify the development of juvenile idiopathic arthritis (JIA) to adult-onset autoimmune diseases in a population-based study in Taiwan.

Methods: We analyzed data of 107 433 children born between 1990 and 1997 from the National Taiwan Health Insurance Database. There were 262 JIA patients and 107 171 individuals without JIA who were selected and followed up until December 2013 to investigate their outcomes of adult-onset autoimmune diseases after reaching 16 years of age. Read More

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http://dx.doi.org/10.1111/1756-185X.13527DOI Listing
February 2019
1 Read
1.771 Impact Factor