19,473 results match your criteria Rheumatoid Spondylitis


Short report: sleep quality and associations with health locus of control and coping styles in young people with ankylosing spondylitis.

Psychol Health Med 2020 Aug 11:1-8. Epub 2020 Aug 11.

Department of Children, Adolescents and Women Health, College of Public Health, Zhengzhou University , Zhengzhou, PR China.

The poor sleep of young people with ankylosing spondylitis (AS) has not attracted enough attention of clinicians and experts. This study aimed to evaluate the sleep quality and associations with health locus of control (HLC) and coping styles in young people with AS. A total of 133 patients completed the measures of demographics, disease characteristics, HLC, coping styles, and Pittsburgh sleep quality index (PSQI). Read More

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http://dx.doi.org/10.1080/13548506.2020.1807576DOI Listing

Post-approval Safety Surveillance Study of Golimumab in the Treatment of Rheumatic Disease Using a United States Healthcare Claims Database.

Clin Drug Investig 2020 Aug 10. Epub 2020 Aug 10.

Optum Epidemiology, 1325 Boylston Street, 11th Floor, Boston, MA, 02215, USA.

Background And Objective: Golimumab is a fully human anti-tumor necrosis factor monoclonal antibody approved for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). This study estimated rates of prespecified outcomes in patients with RA, PsA or AS initiating golimumab versus matched patients initiating non-biologic systemic (NBS) medications.

Methods: Patients enrolled in a US health plan with rheumatic disease who initiated a study medication were accrued between April 2009 and November 2014. Read More

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http://dx.doi.org/10.1007/s40261-020-00959-7DOI Listing

[Adherence to biological therapies in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. (Study ADhER-1)].

Semergen 2020 Aug 7. Epub 2020 Aug 7.

Servicio de Farmacia, Hospital San Pedro, Logroño, España.

Background: To quantify adherence to biological disease-modifying anti-rheumatic drugs (DMARD) and to determine the factors that can predict adherence in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis in daily clinical practice.

Methods: An observational, descriptive, cross-sectional and single-center study was carried out. Patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis who were in treatment with subcutaneous biological DMARD were included. Read More

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http://dx.doi.org/10.1016/j.semerg.2020.06.024DOI Listing

Open-label non-mandatory transitioning from originators to biosimilars in routine clinical care.

Clin Rheumatol 2020 Aug 10. Epub 2020 Aug 10.

Rheumatology Unit, "Villa Sofia - Cervello" Hospital, via del Fante, 90144, Palermo, Italy.

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http://dx.doi.org/10.1007/s10067-020-05327-6DOI Listing

Prevalence and variables associated with fatigue in psoriatic arthritis: a cross-sectional study.

Rheumatol Int 2020 Aug 9. Epub 2020 Aug 9.

Department of Rheumatology and Immunology, Singapore General Hospital, The Academia, Level 4, 20 College Road, Singapore, 169856, Singapore.

Objective: To describe the prevalence of and evaluate the factors associated with fatigue patients with psoriatic arthritis (PsA) in an Asian population.

Methods: We used baseline data from a registry of patients with PsA attending an outpatient clinic of a tertiary hospital in Singapore. Demographic data and disease characteristics were evaluated. Read More

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http://dx.doi.org/10.1007/s00296-020-04678-2DOI Listing

Abnormal subgenual anterior cingulate circuitry is unique to women but not men with chronic pain.

Pain 2020 Aug 5. Epub 2020 Aug 5.

Division of Brain, Imaging, and Behaviour, Krembil Brain Institute, Krembil Research Institute, University Health Network, Toronto, Canada.

The subgenual anterior cingulate cortex (sgACC) plays an important role in pain modulation. We previously demonstrated sex differences in sgACC functional connectivity (FC) in healthy individuals. Given that many chronic pain conditions show sex differences in prevalence, here we tested the hypothesis that people with chronic pain exhibit a sex-specific pattern of abnormal sgACC FC. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000002016DOI Listing

Extraluminal bronchial blocker placement using both nostrils for lung isolation in a patient with limited mouth opening: A CARE-compliant case report.

Medicine (Baltimore) 2020 Aug;99(32):e21521

Department of Anesthesia, Shaoxing University Affiliated First Hospital.

Rationale: The establishment of lung isolation is often particularly challenging for the anesthesiologist in patients with difficult airway. Usually, orotracheal intubation with double lumen tube is the commonly used technique for achieving 1 lung anesthesia. Whereas, in patients with limited mouth opening and restricted cervical mobility, this technique becomes extremely difficult and hazardous. Read More

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http://dx.doi.org/10.1097/MD.0000000000021521DOI Listing

Is fibromyalgia frequency increasing in axial spondyloarthritis? Association with fibromyalgia and biological therapies.

Rheumatol Int 2020 Aug 7. Epub 2020 Aug 7.

Department of Physical Medicine and Rehabilitation, Ankara City Hospital, Ankara, Turkey.

Fibromyalgia (FM) is known a common painful syndrome and its frequency is increased in inflammatory rheumatic diseases. We aimed to assess FM frequency in axial spondyloarthritis (AxSpA) patients and age- and sex-matched healthy controls with the 2011 ACR FM criteria. We evaluated the association between receiving biologic disease-modifying antirheumatoid drugs (bDMARD) and presence of FM. Read More

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http://dx.doi.org/10.1007/s00296-020-04670-wDOI Listing

GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis.

Front Immunol 2020 16;11:1520. Epub 2020 Jul 16.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

GM-CSF is a pro-inflammatory cytokine with multiple actions predominantly on myeloid cells. Enhanced GM-CSF expression by lymphocytes from patients with Ankylosing Spondylitis (AS) has recently been described, however, its potential pathogenic role(s) in AS are unknown. The effects of GM-CSF on TNF, IL-23, and CCL17 production by blood, PBMCs and isolated CD14+ monocytes from AS patients and healthy controls (HCs) were studied using ELISA. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378736PMC

Associations between fucosyltransferase 3 gene polymorphisms and ankylosing spondylitis: A case-control study of an east Chinese population.

PLoS One 2020 7;15(8):e0237219. Epub 2020 Aug 7.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Many susceptibility genes of inflammatory bowel disease (IBD) are associated with ankylosing spondylitis (AS). Fucosyltransferase 2 (FUT2) and FUT3 genes are related to IBD. This study aimed to investigate whether these genes correlated with the susceptibility to AS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237219PLOS

Are there any clinical differences between ankylosing spondylitis patients and familial mediterranean fever patients with ankylosing spondylitis?

Int J Clin Pract 2020 Aug 5:e13645. Epub 2020 Aug 5.

Kocaeli University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Kocaeli, Turkey.

Objective: Familial Mediterranean Fever (FMF) is an autoinflammatory disease that commonly present with recurrent episodes of fever, peritonitis, pleuritis, or arthritis. Enthesitis and sacroilitis can also be seen in FMF. Spondylitis is a less common manifestation of joint involvement in FMF, and there are controversial publications about whether this involvement is FMF-related or coincidentally. Read More

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http://dx.doi.org/10.1111/ijcp.13645DOI Listing

A prospective study of novel disease activity indices for ankylosing spondylitis.

Rheumatol Int 2020 Aug 5. Epub 2020 Aug 5.

Departments of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India.

There is an ongoing quest for robust disease activity measures in Ankylosing spondylitis (AS). Thus, we prospectively validated two new disease activity indices, Simplified AS Disease Activity Score (SASDAS) and modified Juvenile Spondyloarthritis Disease Activity Score (JSpADA). Patients with AS were assessed for BASDAI, ASDAS and other outcome measures at baseline and 3 months. Read More

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http://dx.doi.org/10.1007/s00296-020-04662-wDOI Listing

Femoral vein wall thickness measurement: A new diagnostic tool for Behçet's disease.

Rheumatology (Oxford) 2020 Aug 5. Epub 2020 Aug 5.

Department of Internal Medicine, Division of Rheumatology, Marmara University School of Medicine, Istanbul.

Objectives: Diagnosing Behçet's disease (BD) is a challenge, especially in countries with a low prevalence. Recently, venous wall thickness (VWT) in lower extremities has been shown to be increased in BD patients. In this study, we aimed to investigate the diagnostic performance of common femoral vein (CFV) thickness measurement in BD and whether it can be used as a diagnostic tool. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa264DOI Listing

IL-22 increases the production of sFRP3 by FLS in inflammatory joint diseases.

Braz J Med Biol Res 2020 3;53(9):e9880. Epub 2020 Aug 3.

Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) are inflammatory diseases with different bone remodeling patterns. Fibroblast-like synoviocytes (FLS) are cells involved in the transition from an acute and reparable phase to a chronic and persistent stage in these diseases. The distinction of joint phenotypes involves inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-17, and IL-22 directly or through key signaling pathways such as Wnt. Read More

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http://dx.doi.org/10.1590/1414-431X20209880DOI Listing

The effectiveness of Du moxibustion for ankylosing spondylitis: A protocol for systematic review and meta-analysis of randomized clinical trials.

Medicine (Baltimore) 2020 Jul;99(31):e21450

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, P.R. China.

Background: Ankylosing spondylitis (AS) is a common progressive autoimmune inflammatory disease. Du moxibustion can effectively treat AS with few adverse reactions. The aim of this protocol is to systematically investigate the effectiveness and safety for management of AS with Du moxibustion. Read More

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http://dx.doi.org/10.1097/MD.0000000000021450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402767PMC

Mesenchymal Stem Cells Anti-Inflammatory Activity in Rats: Proinflammatory Cytokines.

J Inflamm Res 2020 7;13:293-301. Epub 2020 Jul 7.

Department of Pathology, Kharkiv National Medical University, Kharkiv, Ukraine.

Introduction: Many widespread intractable diseases are caused or supported by chronic inflammation. Such conditions include the 2nd type of diabetes mellitus, atherosclerosis, neurodegenerative diseases, chronic inflammatory diseases of the connective tissue - ankylosing spondylitis, rheumatoid arthritis, autoimmune myositis, etc. Therefore, the search for targeted treatment of these illnesses is extremely in high demand. Read More

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http://dx.doi.org/10.2147/JIR.S256932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354011PMC

The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review.

Hum Reprod Update 2020 Aug 3. Epub 2020 Aug 3.

Netherlands Pharmacovigilance Centre Lareb, 5237 MH 's-Hertogenbosch, The Netherlands.

Background: Information regarding the possible influence of immunosuppressive drugs on male sexual function and reproductive outcomes is scarce. Men diagnosed with immune-mediated diseases and a wish to become a father represent an important neglected population since they lack vital information to make balanced decisions about their treatment.

Objective And Rationale: The aim of this research was to systematically review the literature for the influence of paternal immunosuppressive drug use on many aspects of male sexual health, such as sexual function, fertility, pregnancy outcomes and offspring health outcomes. Read More

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http://dx.doi.org/10.1093/humupd/dmaa022DOI Listing

MicroRNAs in ankylosing spondylitis: Function, potential and challenges.

J Transl Autoimmun 2020 21;3:100050. Epub 2020 Mar 21.

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, IRCCS, Rozzano, Milan, Italy.

Epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNA, are considered the essential connection between a disorder's onset and the environment, on a permissive genetic background. Among autoimmune and inflammatory-mediated disorders, Ankylosing Spondylitis (AS), a chronic arthritis of the spine, is a very good example for the weight of epigenetics' contribution. MicroRNAs (miRNAs) are single-stranded nucleotides which regulate gene expression and are involved in pathological and physiological processes. Read More

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http://dx.doi.org/10.1016/j.jtauto.2020.100050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388379PMC

Perioperative Management of Patients With Ankylosing Spondylitis Undergoing Spine Surgery.

Front Pharmacol 2020 9;11:1017. Epub 2020 Jul 9.

Department of Rheumatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.

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http://dx.doi.org/10.3389/fphar.2020.01017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364138PMC

Infliximab induced chronic inflammatory demyelinating polyneuropathy: a case report.

Hippokratia 2019 Oct-Dec;23(4):179-180

3Department of Neurology, Aristotle University of Thessaloniki, G.Papanikolaou General Hospital, Thessaloniki, Greece.

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated disease of the peripheral nervous system characterized by motor weakness, sensory symptoms, areflexia, and specific electrophysiological findings. Rarely, Anti-Tumor Necrosis Factor-alpha (anti-TNFa) agents, which are used as a treatment for immune-mediated diseases, can cause neurological adverse effects on the central nervous system, as well as peripheral nervous system demyelination.

Case Report: We describe the case of a 63-year-old woman with ankylosing spondylitis who developed chronic inflammatory demyelinating polyneuropathy after infliximab initiation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377590PMC

Role of the NLRP3 inflammasome in autoimmune diseases.

Biomed Pharmacother 2020 Jul 29;130:110542. Epub 2020 Jul 29.

Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China. Electronic address:

NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that senses foreign pathogens and endogenous danger signals. It assembles with apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1 to form a multimeric protein called the NLRP3 inflammasome. Among its various functions, the NLRP3 inflammasome can induce the release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 while also promoting gasdermin D (GSDMD)-mediated pyroptosis. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110542DOI Listing

Recognizing Axial Spondyloarthritis: A Guide for Primary Care.

Mayo Clin Proc 2020 Jul 29. Epub 2020 Jul 29.

University of Utah and Salt Lake City Veterans Affairs Medical Center, Salt Lake City, UT.

Axial spondyloarthritis (axSpA) is an important cause of chronic low back pain and affects approximately 1% of the US population. The back pain associated with axSpA has a characteristic pattern referred to as inflammatory back pain (IBP). Features of IBP include insidious onset before age 45 years, association with morning stiffness, improvement with exercise but not rest, alternating buttock pain, and good response to treatment with nonsteroidal anti-inflammatory drugs. Read More

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http://dx.doi.org/10.1016/j.mayocp.2020.02.007DOI Listing

The Valued Life Activities Scale (VLAs): linguistic validation, cultural adaptation and psychometric testing in people with rheumatic and musculoskeletal diseases in the UK.

BMC Musculoskelet Disord 2020 Jul 30;21(1):505. Epub 2020 Jul 30.

Centre for Health Sciences Research, University of Salford, Frederick Road Campus, Brian Blatchford Building PO.50, Salford, M6 6PU, UK.

Background: The Valued Life Activities Scale (VLAs) measures difficulty in daily activities and social participation. With various versions involving a different number of items, we have linguistically and culturally adopted the full VLAs (33-items) and psychometrically tested it in adults with rheumatic and musculoskeletal diseases in the United Kingdom.

Methods: Participants with Rheumatoid Arthritis, Ankylosing Spondylitis, Chronic Pain/ Fibromyalgia, Chronic Hand/ Upper Limb Conditions, Osteoarthritis, Systemic Lupus, Systemic Sclerosis and Primary Sjogren's Syndrome were recruited from out-patient clinics in National Health Service Hospitals, General Practice and patient organisations in the UK. Read More

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http://dx.doi.org/10.1186/s12891-020-03409-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393896PMC

Anemia in patients with ankylosing spondylitis, association with the activity of the inflammatory process and the severity of the disease.

Wiad Lek 2020 ;73(4):715-721

National Pirogov Memorial Medical University, Vinnytsia, Ukraine, Scientific and Research Institute of Invalid Rehabilitation (Educational Scientific Treatment Complex) of National Pirogov Memorial Medical University, Vinnytsia, Ukraine.

Objective: The aim: To estimate the prevalence of anemia in patients with ankylosing spondylitis, major pathogenetic variants and their relationship with the activity of the inflammatoryprocess and the severity of the disease.

Patients And Methods: Materials and methods: 118 patients with ankylosing spondylitis participated in the study, which performed hematologic, biochemical, immunological studies with general haemopoiesis and ferrokinetics parameters, plasma levels of CRP and IL-6.

Results: Results: It was found that in Ukrainian population of patients with ankylosing spondylitis, 28. Read More

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Association of IFN-γ polymorphisms with ankylosing spondylitis risk.

J Cell Mol Med 2020 Jul 30. Epub 2020 Jul 30.

Department of Orthopedics, Harrison International Peace Hospital, The People's Hospital of Hengshui City, Hengshui, China.

The case-control study was designed to investigate the genetic effects of interferon-gamma (IFN-γ) rs2069727 and rs1861494 polymorphisms on ankylosing spondylitis (AS) susceptibility in a Chinese Han population. Blood samples were collected from 108 AS patients and 110 healthy controls. IFN-γ polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Read More

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http://dx.doi.org/10.1111/jcmm.15680DOI Listing

Ixekinumab for the treatment of ankylosing spondylitis.

Expert Rev Clin Immunol 2020 Jul 30. Epub 2020 Jul 30.

Department of Rheumatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University , Nanjing, China.

Introduction: Ixekinumab (IXE) is a high affinity IgG4 approved for the treatment of ankylosing spondylitis (AS). Recently, two phase III randomized clinical trials (COAST-V, COAST-W) showed significant and sustained improvements in signs and symptoms of AS as evaluated by ASAS40 response. : The authors performed a comprehensive literature search on this topic, by a review of published articles to date. Read More

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http://dx.doi.org/10.1080/1744666X.2020.1803063DOI Listing

Frequency of peripheral diseases in Korean patients with ankylosing spondylitis and the effectiveness of adalimumab.

Int J Rheum Dis 2020 Jul 29. Epub 2020 Jul 29.

Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Aim: Peripheral features contribute to disease burden in ankylosing spondylitis (AS). This study investigated the frequency of peripheral disease and effectiveness of adalimumab among Korean patients with AS.

Methods: Peripheral disease was evaluated in consecutively enrolled patients with active AS (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] score ≥ 4). Read More

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http://dx.doi.org/10.1111/1756-185X.13917DOI Listing

Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells.

RMD Open 2020 Jul;6(2)

UCB Pharma, Slough, UK

Objectives: Interleukin (IL)-17 signalling has been shown to be a key regulator of disease in ankylosing spondylitis (AS) with several IL-17 blockers currently clinically approved. Despite this, the role of IL-17 in bone pathology is poorly understood. This study aimed to investigate IL-17 signalling in the context of pathological bone formation. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001306DOI Listing

Preliminary analysis of interaction of the fat fraction in the sacroiliac joint among sex, age, and body mass index in a normal Chinese population.

J Int Med Res 2020 Jul;48(7):300060520931281

Department of Radiology, The First Medical Centre, Chinese PLA General Hospital, Beijing, China.

Objective: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation-iron quantification (IDEAL-IQ) is a noninvasive and objective method used to quantitatively measure fat content. Although this technique has been used in the entire abdomen, IDEAL-IQ findings in the sacroiliac joint (SIJ) have rarely been reported. This preclinical study was performed to quantify the amount of fat in the SIJ in healthy volunteers by IDEAL-IQ. Read More

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http://dx.doi.org/10.1177/0300060520931281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391443PMC

Golimumab improves patient-reported outcomes in daily practice of inflammatory rheumatic diseases in Germany.

J Comp Eff Res 2020 Jul 29. Epub 2020 Jul 29.

Medical Affairs, MSD Sharp & Dohme GmbH, Lindenplatz 1, Haar, 85540, Germany.

To analyze the quality of life (QoL), work productivity and activity impairment (WPAI) and healthcare resource utilization (HCRU) in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients receiving golimumab under routine clinical settings in Germany. Prospective observational study, GO-ART, analyzed changes in WPAI, QoL and HCRU during 24 months of golimumab therapy. Seven hundred and forty-eight patients (RA = 250, PsA = 249 and AS = 249) were enrolled. Read More

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http://dx.doi.org/10.2217/cer-2020-0092DOI Listing

Work Disability in Axial Spondyloarthritis.

Curr Rheumatol Rep 2020 Jul 27;22(9):55. Epub 2020 Jul 27.

Leiden University Medical Center, Leiden, The Netherlands.

Purpose Of Review: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that typically affects people of working age. Work-related outcomes are therefore important to study, both from an individual but also a societal perspective. Through this review of the literature, we explore the impact of axSpA on key work outcomes including work and productivity loss and predictors for these. Read More

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http://dx.doi.org/10.1007/s11926-020-00932-5DOI Listing

Paradoxical gastrointestinal effects of interleukin-17 blockers.

Ann Rheum Dis 2020 Jul 21. Epub 2020 Jul 21.

Department of Gastroenterology and Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France

Secukinumab, ixekizumab and brodalumab are monoclonal antibody therapies that inhibit interleukin (IL)-17 activity and are widely used for the treatment of psoriasis, psoriatic arthritis and ankylosing spondylitis. The promising efficacy results in dermatology and rheumatology prompted the evaluation of these drugs in Crohn's disease and ulcerative colitis, but the onset of paradoxical events (disease exacerbation after treatment with a theoretically curative drug) prevented their approval in patients with inflammatory bowel diseases (IBDs). To date, the pathophysiological mechanisms underlying these paradoxical effects are not well defined, and there are no clear guidelines for the management of patients with disease flare or new IBD onset after anti-IL-17 drug therapy. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217927DOI Listing

Ankylosing spondylitis is associated with an increased risk of dementia: A systematic review and meta-analysis.

Int J Rheum Dis 2020 Jul 27. Epub 2020 Jul 27.

Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH, USA.

Objectives: To investigate the relationship between ankylosing spondylitis (AS) and risk of dementia.

Methods: Potentially eligible studies that compared the risk of developing dementia between patients with AS and individuals without AS were identified from MEDLINE and EMBASE databases from inception to May 2019 using a search strategy that comprised terms for "dementia" and "ankylosing spondylitis". Eligible studies could be either cohort studies or case-control studies. Read More

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http://dx.doi.org/10.1111/1756-185X.13920DOI Listing

Is Axial Spondyloarthritis More Common Than Rheumatoid Arthritis?

Curr Rheumatol Rep 2020 Jul 25;22(9):54. Epub 2020 Jul 25.

MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.

Purpose Of Review: To discuss the disease incidence and prevalence rates of axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS) relative to those of rheumatoid arthritis (RA).

Recent Findings: According to the most recently published systematic reviews, pooled prevalence estimates for RA are 0.38% in North America, and 0. Read More

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http://dx.doi.org/10.1007/s11926-020-00934-3DOI Listing

Assessing the effect of interventions for axial spondyloarthritis according to the endorsed ASAS/OMERACT core outcome set: a meta-research study of trials included in Cochrane reviews.

Arthritis Res Ther 2020 Jul 25;22(1):177. Epub 2020 Jul 25.

Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital, University Hospital, Copenhagen F, Denmark.

The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record keeping, and (iii) disease-controlling anti-rheumatic therapy (DC-ART). These include the following domains for all three core sets: "physical function," "pain," "spinal mobility," "spinal stiffness," and "patient's global assessment" (PGA). The core set for clinical record keeping further includes the domains "peripheral joints/entheses" and "acute phase reactants," and the core set for DC-ART further includes the domains "fatigue" and "spine radiographs/hip radiographs. Read More

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http://dx.doi.org/10.1186/s13075-020-02262-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382035PMC

Diagnostic value of anti-CD74 antibodies in early and late axial spondyloarthritis and its relationship to disease activity.

Rheumatology (Oxford) 2020 Jul 24. Epub 2020 Jul 24.

Medical Microbiology and Immunology Department, Assiut University, Assiut, Egypt.

Objectives: This study was designed to evaluate the role of anti-CD74 antibodies in diagnosis of axial spondyloarthritis (axSpA) and their relationship to disease duration and disease activity.

Methods: Fifty patients with axSpA, 15 patients with RA and 15 healthy subjects were included in the study. Clinical examination and laboratory tests were done. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa292DOI Listing

Assessment of radiographic sacroiliitis in anteroposterior lumbar vs conventional pelvic radiographs in axial spondyloarthritis.

Rheumatology (Oxford) 2020 Jul 24. Epub 2020 Jul 24.

Gastroenterology, Infectious Diseases and Rheumatology Department, Charité Universitätsmedizin Berlin.

Objective: The aim was to investigate the reliability and validity of radiographic sacroiliitis assessment in anteroposterior (AP) lumbar radiographs compared with conventional pelvic radiographs in patients with axial spondyloarthritis (axSpA).

Methods: Patients from the German Spondyloarthritis Inception Cohort were selected based on the availability of pelvic and AP lumbar radiographs with visible SI joints at baseline and year 2. Two readers scored the images independently in a random order according to the modified New York criteria. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa260DOI Listing

Paediatric infections in the first 3 years of life after maternal anti-TNF treatment during pregnancy.

Aliment Pharmacol Ther 2020 Jul 24. Epub 2020 Jul 24.

Stockholm, Sweden.

Background: Most anti-tumour necrosis factor (anti-TNF) agents are transferred across the placenta and may increase paediatric susceptibility to infections.

Aims: To assess the risk of paediatric infections after maternal anti-TNF treatment.

Methods: Population-based cohort study in Denmark, Finland and Sweden 2006-2013 in which 1027 children born to women with rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis or inflammatory bowel disease, treated with anti-TNF, and 9346 children to women with nonbiologic systemic treatment, were compared to 1 617 886 children of the general population. Read More

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http://dx.doi.org/10.1111/apt.15971DOI Listing

MicroRNA‑204‑5p inhibits the osteogenic differentiation of ankylosing spondylitis fibroblasts by regulating the Notch2 signaling pathway.

Mol Med Rep 2020 Sep 6;22(3):2537-2544. Epub 2020 Jul 6.

Department of Trauma Orthopedics, The No. 4 Hospital of Jinan, Jinan, Shandong 250031, P.R. China.

Ankylosing spondylitis (AS) is a chronic inflammatory systemic disease and is difficult to detect in the early stages. The present study aimed to investigate the role of microRNA (miR)‑204‑5p in osteogenic differentiation of AS fibroblasts. Bone morphogenetic protein 2 (BMP‑2) was used to induce osteogenic differentiation. Read More

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http://dx.doi.org/10.3892/mmr.2020.11303DOI Listing
September 2020

Recent advances in managing axial spondyloarthritis.

F1000Res 2020 13;9. Epub 2020 Jul 13.

Department of Rheumatology, Northwick Park Hospital, London North West University NHS Trust, London, UK.

Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease that predominantly affects the axial skeleton. The advent of biologic drugs has transformed the management of patients with axSpA. However, non-steroidal anti-inflammatory drugs remain the first-line drug treatment for axSpA. Read More

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http://dx.doi.org/10.12688/f1000research.22577.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359748PMC

Etanercept in the treatment of ankylosing spondylitis and nephrotic syndrome in the context of AA amyloidosis: A 48-month follow-up.

Nefrologia 2020 Jul 20. Epub 2020 Jul 20.

Division of Nephrology - Centro Hospitalar e Universitário do Algarve - Faro, Portugal; University of Algarve - Department of Biomedical Sciences and Medicine - Faro, Portugal.

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http://dx.doi.org/10.1016/j.nefro.2020.04.019DOI Listing

The American College of Rheumatology Fibromyalgia Criteria Are Useful in the Evaluation of Fibromyalgia Symptoms in Patients With Ankylosing Spondylitis: A Cross-Sectional Study.

J Clin Rheumatol 2020 Jul 22. Epub 2020 Jul 22.

From the Case Western Reserve University School of Medicine at MetroHealth Medical Center.

Background: Fibromyalgia (FM) is common among patients with ankylosing spondylitis (AS), and its coexistence is believed to interfere with the measurement of patient-reported outcomes of disease activity and function in AS because of overlapping symptoms between the 2 diseases. This can confound clinical assessment and treatment decisions.

Aims: The aim of this study was to assess the relationship between the Fibromyalgia Symptom Scale (FSS) and its components, the Widespread Pain Index (WPI), and System Severity Scale with measures of disease activity, function, and patient-reported outcomes in AS. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001490DOI Listing

Pharmaco-utilization of biologic drugs in patients affected by psoriasis, psoriatic arthritis and ankylosing spondylitis in an Italian real-world setting.

Expert Rev Pharmacoecon Outcomes Res 2020 Jul 23. Epub 2020 Jul 23.

Health, Economics & Outcomes Research, CliCon S.r.l ., Ravenna, Italy.

Background: The study primary aim was to evaluate the monthly average dose for biologic drugs used for psoriasis (PSO), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) in real-world settings.

Methods: This retrospective analysis was based on administrative databases of Italian Entities. Adult patients with PSO, PsA or AS diagnosis and ≥1 prescription of biologic drugs indicated for these diseases were included during 01/01/2011-30/06/2017. Read More

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http://dx.doi.org/10.1080/14737167.2020.1800456DOI Listing

Effects of mannuronic acid (M2000) on gene expression profile of signal transducer and activator of transcription proteins (STATs) in rheumatoid arthritis patients.

Reumatismo 2020 Jul 23;72(2):93-102. Epub 2020 Jul 23.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran; Research Centre for Immunodeficiencies, Children's Medical Centre, Tehran University of Medical Sciences, Tehran.

Rheumatoid arthritis (RA), a form of inflammatory arthritis, is a chronic joint disease characterized by pain and inflammation that affects 0.5% to 1% of the population worldwide. The safety, efficacy, tolerability, and potency of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property has been reported by several in vitro studies, experimental models and clinical trials phase I/II and III in ankylosing spondylitis and rheumatoid arthritis (RA) patients This research is designed to study the therapeutic efficacy of oral administration of mannuronic acid in RA patients who had inadequate response to conventional drugs and to assess the effect of this drug on gene expression of the signal transducer and activator of transcription (STATs) protein (STAT1, STAT3, STAT4, and STAT6). Read More

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http://dx.doi.org/10.4081/reumatismo.2020.1235DOI Listing

[Whole exome sequencing in a pedigree with ankylosing spondylitis].

Zhongguo Gu Shang 2020 Jul;33(7):672-6

Xiaoshan District Hospital of Traditional Chinese Medicine in Hangzhou City, Hangzhou 311201, Zhejiang, China.

Objective: To choose the disease-causing gene in a Chinese pedigree with ankylosing spondylitis (AS) by whole-exome sequencing (WES), and provide theory basis for mechanism of disease.

Methods: Clinical data of AS pedigree were collected, including 2 males, the age were 48 and 18 years old, the course of disease were 23 and 4 years. Whole blood genomic DNA of AS was extracted to perform whole exome sequencing, the results were compared with human databases, common variations which had been reported were wiped out, then non synonymous single nucleotide variants(SNVs) from the family members were combined, and candidate genes was selected initially. Read More

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http://dx.doi.org/10.12200/j.issn.1003-0034.2020.07.017DOI Listing

[Experimental study of individualized 3D printing-guided template combined with thoracolumbar pedicle screw placement for the treatment of ankylosing spondylitis].

Zhongguo Gu Shang 2020 Jul;33(7):649-54

Department of Orthopaedics, the Second Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui, China.

Objective: To evaluate accuracy and safety of individualized 3D printing guided template for thoracolumbar pedicle screw placement in patients with ankylosing spondylitis.

Methods: From January 2016 to September 2019, thoracolumbar spine three-dimensional CT data of 8 patients with ankylosing spondylitis were included, Mimics 17.0 and ideaMaker computer software were applied to design thoracolumbar pedicle screw guided template of patients with AS, physical model of all patients (T-L)were printed by 3D printer, 2 parts in each patient, and divided into guide-plate-assisted screw group (experimental group) and free-hand nail group (control group). Read More

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http://dx.doi.org/10.12200/j.issn.1003-0034.2020.07.011DOI Listing

Using qualitative methods for a conceptual analysis of measures of health status and presenteeism prior to a mapping study.

Qual Life Res 2020 Jul 22. Epub 2020 Jul 22.

Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal & Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Objectives: The inclusion of productivity in economic evaluations is a contentious issue. Methods are currently being developed to assess how it may feasibly be included for specific interventions, such as workplace interventions (WPIs), where productivity is a key outcome. Mapping (also called cross-walking or prediction modelling) may offer a solution. Read More

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http://dx.doi.org/10.1007/s11136-020-02570-xDOI Listing
July 2020
2.486 Impact Factor

Classification criteria: time for a rethink?

Ann Rheum Dis 2020 Jul 22. Epub 2020 Jul 22.

Institute of Infection Immunity and Inflammation, University of Glasgow College of Medical Veterinary and Life Sciences, Glasgow, UK.

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http://dx.doi.org/10.1136/annrheumdis-2020-217769DOI Listing

[Phosphoproteomic analysis of peripheral blood mononuclear cells of ankylosing spondylitis patients].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2020 May;36(5):444-450

Department of Clinical Laboratory, Tianjin Hospital, Tianjin 300142, China.

Objective To investigate the changes of protein phosphorylation in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and its potential regulatory role in AS. Methods PBMCs were obtained from 20 cases of AS without treatment, 15 cases of AS with drug treatment, and 20 matched healthy controls. Protein extraction, trypsin digestion, phosphorylated peptide enrichment and mass spectrometric analyses were performed. Read More

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New Developments in our Understanding of Ankylosing Spondylitis Pathogenesis.

Immunology 2020 Jul 22. Epub 2020 Jul 22.

Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science (NDORMS), Botnar Research Centre, University of Oxford, Headington, Oxford, OX3 9DL, United Kingdom.

Ankylosing Spondylitis (AS) is a common immune-mediated inflammatory arthritis with a strong genetic predisposition. We review recent data from genetic and animal studies highlighting the importance of Type 17 immune responses. Furthermore, the efficacy (or lack thereof) of different anti-cytokine monoclonal antibodies has highlighted the diversity of Type 17 immune cells and cytokines critical to AS and related spondyloarthritis pathogenesis. Read More

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http://dx.doi.org/10.1111/imm.13242DOI Listing