1,682 results match your criteria Rheumatoid Arthritis and Pregnancy


Moderate-to-severe psoriasis and pregnancy: impact on fertility, pregnancy outcome and treatment perspectives.

G Ital Dermatol Venereol 2019 Jun;154(3):305-314

Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Psoriasis affects 2-4% of the world's population, with no difference between men and women and 70% of patients experiencing disease onset before the age of 40, which coincides with the reproductive years. Few data are available from literature on impact of psoriasis on fertility, course and outcome of pregnancy and risk associated with treatments. Recent studies on other immune-mediated inflammatory diseases, among which psoriasis is also included, indicate that rheumatoid arthritis and inflammatory bowel diseases can impact female fertility and pregnancy outcomes especially during active disease episodes. Read More

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https://www.minervamedica.it/index2.php?show=R23Y2019N03A030
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http://dx.doi.org/10.23736/S0392-0488.18.06255-7DOI Listing
June 2019
1 Read

Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.

Front Immunol 2019 29;10:659. Epub 2019 Mar 29.

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Feto-maternal microchimerism (FMM) involves bidirectional cross-placental trafficking during pregnancy, leading to a micro-chimeric state that can persist for decades. In this manner a pregnant woman will harbor cells from her mother, as well as, cells from her child. Historically, eclampsia, a severe disorder of pregnancy provided the basis for FMM following the detection of trophoblast cells in the lungs of deceased women. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00659
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http://dx.doi.org/10.3389/fimmu.2019.00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455070PMC
March 2019
1 Read

Obstetric outcomes in women with rheumatoid arthritis: Results from Nationwide Inpatient Sample Database 2003-2011.

Semin Arthritis Rheum 2019 Mar 23. Epub 2019 Mar 23.

University of Mississippi, 2500 North State Street, Jackson, MS 39232, United States.

Objective: Fertility is reduced in patients with Rheumatoid Arthritis due to unknown cause. Few studies have addressed pregnancy outcomes in RA. This study was undertaken to determine the frequency of complications occurring during pregnancy for women with RA and compare with the general obstetric population by using the largest inpatient care database. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.011DOI Listing
March 2019
1 Read

Clinical application of the dried milk spot method for measuring tocilizumab concentrations in the breast milk of patients with rheumatoid arthritis.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Tokyo, Japan.

Aims: Tocilizumab (TCZ), a humanized anti-interleukin-6 receptor monoclonal antibody, is used to treat rheumatic diseases. There is limited information about the administration of TCZ during lactation. The dried spot method, a simple technique for processing biological samples which involves placement of a drop of specimen onto filter paper, has been used in clinical pharmacology to determine various drug concentrations. Read More

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http://dx.doi.org/10.1111/1756-185X.13557DOI Listing
April 2019
2 Reads

Modulatory Effects of Pregnancy on Inflammatory Bowel Disease.

Clin Transl Gastroenterol 2019 Mar;10(3):e00009

Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands.

The disease course of autoimmune diseases such as rheumatoid arthritis is altered during pregnancy, and a similar modulatory role of pregnancy on inflammatory bowel disease (IBD) has been proposed. Hormonal, immunological, and microbial changes occurring during normal pregnancy may interact with the pathophysiology of IBD. IBD consists of Crohn's disease and ulcerative colitis, and because of genetic, immunological, and microbial differences between these disease entities, they may react differently during pregnancy and should be described separately. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445610PMC
March 2019
1 Read

A review of the influence of periodontal treatment in systemic diseases.

Periodontol 2000 2019 02;79(1):117-128

Department of Periodontology, Dental School, University of Sevilla, Sevilla, Spain.

The effects and consequences of periodontal diseases might not be confined to the oral cavity. A great body of evidence has arisen supporting the claim demonstrating an association with several systemic conditions and diseases. With different levels of evidence, an association between periodontal disease and cardiovascular disease, diabetes, psoriasis, rheumatoid arthritis, pregnancy outcomes and respiratory diseases has been established. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/prd.12249
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http://dx.doi.org/10.1111/prd.12249DOI Listing
February 2019
11 Reads

[Assisted fertilization with at term pregnancies in two patients with severe rheumatoid arthritis while in treatment with etanercept.]

Rev Fac Cien Med Univ Nac Cordoba 2019 03 6;76(1):59-62. Epub 2019 Mar 6.

Cátedra de Semiología. Unidad hospitalaria Nro 2 Hospital "San Roque". Facultad de Ciencias Médicas. Universidad Nacional de Córdoba.

Introduction: There are numerous reports of patients with rheumatoid arthritis (RA) who became pregnant while on treatment with etanercept. In spite of being formally contraindicated during pregnancy and lactation its discontinuation in cases of women with severe RA is no longer recommended since an increase in congenital malformations nor perinatal complications has not been reported. There are few data on the success or failure of pregnancies achieved by assisted fertilization in patients with RA treated with etanercept. Read More

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https://revistas.unc.edu.ar/index.php/med/article/view/21959
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http://dx.doi.org/10.31053/1853.0605.v76.n1.21959DOI Listing
March 2019
7 Reads

Useful message in choosing optimal biological agents for patients with autoimmune arthritis.

Biochem Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, ROC. Electronic address:

The introduction of biological disease-modifying antirheumatic drug (bDMARD) treatments for various types of autoimmune arthritis, such as rheumatoid arthritis, psoriatic arthropathy and ankylosing spondylitis, represents a new era of treatment for patients with a refractory response to conventional synthetic DMARDs (csDMARDs). Many new bDMARDs with different modalities or that target different pro-inflammatory molecules, likely cytokines, are rapidly emerging. Hence, physicians in the field may be confused about choosing appropriate bDMARDs for their patients. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.03.007DOI Listing
March 2019
1 Read

Family Planning and Rheumatoid Arthritis.

Curr Rheumatol Rep 2019 Mar 6;21(5):16. Epub 2019 Mar 6.

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, 3500 Terrace Street, Pittsburgh, PA, 15261, USA.

Purpose Of Review: Patients with rheumatoid arthritis (RA) have special family planning considerations that require close coordination with health care providers. While this article focuses on issues inherent to female patients given their potential for pregnancy, we will review pertinent issues related to medication counseling for male patients.

Recent Findings: Some women with RA may experience subfertility. Read More

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http://link.springer.com/10.1007/s11926-019-0816-y
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http://dx.doi.org/10.1007/s11926-019-0816-yDOI Listing
March 2019
5 Reads

In rheumatoid arthritis fewer women breastfeed their offspring compared with women from the general population; results from a nationwide prospective cohort study.

J Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

From the Department of Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands. This study was funded by the Dutch Arthritis Association (Reumafonds), a noncommercial fund raising organisation. Dr. R.J.E.M. Dolhain received an unrestricted grant from UCB Pharma B.V. Address correspondence Hilal Ince-Askan, MD, Erasmus MC, department of Rheumatology, Room Na-523, PO box 2040, 3000 CA Rotterdam, The Netherlands. E-mail:

Objective: The World Health Organization recommends to exclusively breastfeed infants until the age of six months. The first objective was to compare breastfeeding frequencies and time of cessation between women with rheumatoid arthritis(RA) and the general population. Second, to identify why patients with RA discontinue breastfeeding. Read More

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http://dx.doi.org/10.3899/jrheum.180805DOI Listing
March 2019
3 Reads

Associations between antenatal prednisone exposure and long-term cortisol and cortisone concentrations in children born to women with rheumatoid arthritis: results from a nationwide prospective cohort study.

RMD Open 2019 30;5(1):e000852. Epub 2019 Jan 30.

Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Objectives: To identify whether children with antenatal prednisone exposure have chronically elevated cortisol and cortisone concentrations, an altered body composition or higher blood pressure. In addition, to identify whether maternal rheumatoid arthritis disease (RA) activity is associated with these alterations.

Methods: In this prospective study, 56 children (mean age=10. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361363PMC
January 2019
3 Reads

2018 update of the APLAR recommendations for treatment of rheumatoid arthritis.

Int J Rheum Dis 2019 Mar 27;22(3):357-375. Epub 2019 Feb 27.

Department of Medicine, Subang Jaya Medical Centre, Subang Jaya, Malaysia.

Aim: To update recommendations based on current best evidence concerning the treatment of rheumatoid arthritis (RA), focusing particularly on the role of targeted therapies, to inform clinicians on new developments that will impact their current practice.

Materials And Methods: A search of relevant literature from 2014 to 2016 concerning targeted therapies in RA was conducted. The RA Update Working Group evaluated the evidence and proposed updated recommendations using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach, to describe the quality of evidence and strength of recommendations. Read More

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http://dx.doi.org/10.1111/1756-185X.13513DOI Listing
March 2019
20 Reads
1.771 Impact Factor

Trial of labor after cesarean section in risk pregnancies: A population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Introduction: In most pregnancies after a cesarean section, a trial of labor is an option. The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate.

Material And Methods: In a cohort study (n = 57 109), using data from the Medical Birth Registry of Norway 1989-2014, women with a second delivery after a first pregnancy cesarean section were included. Read More

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http://dx.doi.org/10.1111/aogs.13565DOI Listing
February 2019
4 Reads

Effect of biologic disease-modifying anti-rheumatic drugs for patients with rheumatoid arthritis who hope to become mothers.

Clin Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Objectives: We examined the effect of biologic disease-modifying anti-rheumatic drugs on the time to pregnancy in patients with rheumatoid arthritis who hope to become mothers. Additionally, we evaluated adverse pregnancy outcomes and risk factors of these drugs.

Method: We retrospectively investigated 25 pregnancies of 19 patients who were taking disease-modifying anti-rheumatic drugs. Read More

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http://dx.doi.org/10.1007/s10067-019-04450-3DOI Listing
February 2019
10 Reads

Discontinuing TNF-inhibitors before gestational week 20 in well-controlled rheumatoid arthritis and juvenile arthritis is not associated with a disease worsening in late pregnancy.

Arthritis Rheumatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics and Family Medicine and Public Health, University of California San Diego, San Diego, California, USA.

Objective: To investigate whether the discontinuation of tumor necrosis factor inhibitors (TNFi) during pregnancy is associated with any changes of the disease course in women with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).

Methods: Pregnant women from the U.S. Read More

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http://doi.wiley.com/10.1002/art.40821
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http://dx.doi.org/10.1002/art.40821DOI Listing
January 2019
15 Reads

Decreased chance of a live born child in women with rheumatoid arthritis after assisted reproduction treatment: a nationwide cohort study.

Ann Rheum Dis 2019 Mar 12;78(3):328-334. Epub 2019 Jan 12.

Department D, Centre of Andrology and Fertility Clinic, Odense University Hospital, Odense, Denmark.

Objectives: No studies have examined the efficacy of assisted reproductive technology (ART) treatment in women with rheumatoid arthritis. Therefore, we examined the chance of live birth after ART treatment in women with rheumatoid arthritis compared with women without rheumatoid arthritis.

Methods: Our cohort study is based on nationwide Danish health registries, comprising all women with an embryo transfer during 1 January 1994 through 30 June 2017. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21461
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http://dx.doi.org/10.1136/annrheumdis-2018-214619DOI Listing
March 2019
12 Reads

Prolactin, autoimmunity, and motherhood: when should women avoid breastfeeding?

Clin Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, 5265601, Tel Hashomer, Israel.

The sexual dimorphic prevalence of autoimmunity represents one of the most alluring observations among the mosaic of autoimmunity. Sex hormones are believed to be a mainstay of this asymmetry. The greater prevalence of autoimmunity among fertile women, disease onset/relapses during pregnancy, and postpartum are some of the points that support this theory. Read More

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http://link.springer.com/10.1007/s10067-018-04415-y
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http://dx.doi.org/10.1007/s10067-018-04415-yDOI Listing
January 2019
16 Reads

Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers.

Genes Immun 2019 Jan 12. Epub 2019 Jan 12.

Genetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA, 94720-3220, USA.

The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during pregnancy. We conducted a case control study using data from the UC San Francisco Mother Child Immunogenetic Study and studies at the Inova Translational Medicine Institute. We imputed human leukocyte antigen (HLA) alleles and minor histocompatibility antigens (mHags). Read More

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http://www.nature.com/articles/s41435-018-0055-7
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http://dx.doi.org/10.1038/s41435-018-0055-7DOI Listing
January 2019
19 Reads
2.913 Impact Factor

Reversible Cerebral Vasoconstriction Syndrome after Administering Etanercept during Puerperium.

J Stroke Cerebrovasc Dis 2019 Apr 8;28(4):e10-e11. Epub 2019 Jan 8.

Department of Internal Medicine, Division of Neurology, St. Marianna University of School of Medicine, Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan.

Our objective is to clarify relationship between reversible cerebral vasoconstriction syndrome and administrating etanercept during puerperium. Several lines of evidence have suggested tumor necrosis factor (TNF) as a mediator of vascular dysfunction associated with estrogen deficiency. A 32-year-old woman resumed etanercept (25 mg/week), a TNF inhibitor, which had been discontinued during pregnancy, because of the deterioration of rheumatoid arthritis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183071
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.012DOI Listing
April 2019
9 Reads

Posterior Reversible Encephalopathy Syndrome with Stroke in Puerperal Woman with High Titer of Anti-Phospholipid IgM Antibody.

Case Rep Obstet Gynecol 2018 3;2018:7438676. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.

Posterior reversible encephalopathy syndrome with stroke is very rare in puerperal women. A 36-year-old nulliparous woman with both rheumatoid arthritis and recurrent pregnancy loss, probably due to a high titer of anti-phospholipid IgM antibody, was referred at 10 weeks of gestation. Low-dose aspirin at 100 mg/day and heparin calcium subcutaneous injection at 10,000 units/day were started before pregnancy and stopped at 35 and 40 weeks, respectively. Read More

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https://www.hindawi.com/journals/criog/2018/7438676/
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http://dx.doi.org/10.1155/2018/7438676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304583PMC
December 2018
13 Reads

17-β-estradiol enhances neutrophil extracellular trap formation by interaction with estrogen membrane receptor.

Arch Biochem Biophys 2019 Mar 24;663:64-70. Epub 2018 Dec 24.

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3, Minamitamagaki, Suzuka-city, Mie, 513-8670, Japan. Electronic address:

Cell death-associated neutrophil extracellular trap formation (NETosis) occurs during various autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, as well as during gestation. Although increasing estrogen concentrations associated with pregnancy might induce NETosis via nuclear estrogen receptor (ERα/ERβ), little is known about the mechanisms associated with estrogen-induced NETosis. Here, we investigated the effects of estrogen (17-β-estradiol; E2) on NETosis, focusing on mechanisms associated with estrogen membrane receptor (GPR30) in neutrophil-like HL-60 cells. Read More

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http://dx.doi.org/10.1016/j.abb.2018.12.028DOI Listing
March 2019
3 Reads

Disease activity assessment of rheumatic diseases during pregnancy: a comprehensive review of indices used in clinical studies.

Autoimmun Rev 2019 Feb 18;18(2):164-176. Epub 2018 Dec 18.

Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy.

Pregnancy requires a special management in women with inflammatory rheumatic diseases (RDs), with the aim of controlling maternal disease activity and avoiding fetal complications. Despite the heterogeneous course of RDs during pregnancy, their impact on pregnancy largely relates to the extent of active inflammation at the time of conception. Therefore, accurate evaluation of disease activity is crucial for the best management of pregnant patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15689972183028
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http://dx.doi.org/10.1016/j.autrev.2018.08.008DOI Listing
February 2019
15 Reads

Prevalence and Incidence of Upper Respiratory Tract Infection Events Are Elevated Prior to the Development of Rheumatoid Arthritis in First-Degree Relatives.

Front Immunol 2018 29;9:2771. Epub 2018 Nov 29.

Central Research Laboratory, State Medical Academy, Kazan, Russia.

The aim of this study was to characterize infection events in a longitudinal cohort of first-degree relatives (FDR) of probands with rheumatoid arthritis (RA) and explore their associations with RA development. To this end, newly diagnosed RA patients ( = 283), unaffected related FDR and age-matched healthy women were ascertained from the Caucasian triple women prospective Tatarstan cohort. In this cohort initiated in 1997, 26/283 (9. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02771
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http://dx.doi.org/10.3389/fimmu.2018.02771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281887PMC
November 2018
13 Reads

Activin A in Mammalian Physiology.

Physiol Rev 2019 01;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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http://dx.doi.org/10.1152/physrev.00002.2018DOI Listing
January 2019
12 Reads
27.324 Impact Factor

Genes and transcription factors related to the adverse effects of maternal type I diabetes mellitus on fetal development.

Mol Cell Probes 2019 02 14;43:64-71. Epub 2018 Nov 14.

Department of Gynecology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan, 250013, China.

Purpose: Maternal type I diabetes mellitus (T1DM) increases the risk of adverse pregnancy outcomes, but the corresponding mechanism is unclear. This study aims to investigate the mechanism underlying the adverse pregnancy outcomes of maternal T1DM.

Methods: Gene expression microarray (GSE51546) was down-loaded from the Gene Expression Omnibus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908508183017
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http://dx.doi.org/10.1016/j.mcp.2018.11.003DOI Listing
February 2019
18 Reads

Fertility and Ovarian Reserve among Women with Rheumatoid Arthritis.

J Rheumatol 2018 Nov 15. Epub 2018 Nov 15.

From the Division of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA. Pfizer Inc. provided the funding for this project through its ASPIRE award program for investigator-initiated studies. It had no say on the design or conduct of the research, and did not alter the manuscript. M.E. Clowse is a consultant for UCB regarding issues surrounding the use of certolizumab for RA in pregnancy. This work does not involve issues of infertility or AMH. A.M. Eudy, PhD, Postdoctoral Associate, Division of Rheumatology and Immunology, Duke University Medical Center; G. McDaniel, PA-C, Clinical Research Coordinator, Division of Rheumatology and Immunology, Duke University Medical Center; W.W. Hurd, MD, MSc, MPH, Professor and Director, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center; M.E. Clowse, MD, MPH, Associate Professor of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center. Address correspondence to A.M. Eudy, Duke University Medical Center, Division of Rheumatology and Immunology, DUMC 3490, Durham, North Carolina 27710, USA. E-mail: Accepted for publication August 10, 2018.

Objective: We sought to identify causes for infertility in women with and without rheumatoid arthritis (RA).

Methods: Women with RA were matched to healthy controls. Differences in anti-Müllerian hormone (AMH) and anovulation were analyzed. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180176
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http://dx.doi.org/10.3899/jrheum.180176DOI Listing
November 2018
24 Reads

Use of tumor necrosis factor-alpha inhibitors during pregnancy among women who delivered live born infants.

Pharmacoepidemiol Drug Saf 2019 Mar 14;28(3):296-304. Epub 2018 Nov 14.

Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Purpose: To describe the use of tumor necrosis factor-alpha inhibitors (TNFis) among pregnancies ending in a live birth and with a diagnosis of ankylosing spondylitis (AS), Crohn's disease (CD), juvenile idiopathic arthritis (JIA), psoriasis (PsO), psoriatic arthritis (PsA), rheumatoid arthritis (RA), or ulcerative colitis (UC).

Methods: We identified pregnancies among women aged 15 to 54 years between 01/01/2004 and 09/30/2015 from 16 health plans participating in Sentinel. We inferred indication using ICD-9-CM codes in the 183-day period before conception. Read More

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http://dx.doi.org/10.1002/pds.4695DOI Listing
March 2019
3 Reads

Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.

J Pharm Sci 2019 Jan 3;108(1):661-673. Epub 2018 Nov 3.

Aston Health Research Group, Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK; Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK. Electronic address:

The insidious nature of Zika virus (ZIKV) infections can have a devastating consequence for fetal development. Recent reports have highlighted that chloroquine (CQ) is capable of inhibiting ZIKV endocytosis in brain cells. We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells. Read More

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http://dx.doi.org/10.1016/j.xphs.2018.10.056DOI Listing
January 2019
3 Reads

Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis.

J Rheumatol 2019 Mar 1;46(3):245-250. Epub 2018 Nov 1.

From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK.

Objective: We performed a systematic review and metaanalysis to assess rheumatoid arthritis (RA) disease activity during pregnancy using objective disease activity scoring systems.

Methods: A systematic review of PubMed, EMBASE/Medline, Cochrane, and LactMed databases was performed. Our inclusion criteria for analysis were prospective studies, more than 5 patients per study, and data on RA using an objective scoring system conducted by a clinician/health professional. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180226
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http://dx.doi.org/10.3899/jrheum.180226DOI Listing
March 2019
3 Reads

Pregnancy Outcomes of Patients Exposed to Adalimumab in Japan.

Dig Dis 2019 10;37(2):123-130. Epub 2018 Oct 10.

Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan.

Background: This is the first retrospective report of pregnancy outcomes after exposure to adalimumab treatment in Japan.

Methods: Using the AbbVie safety database, we analyzed pregnancy outcome data from patients who received adalimumab treatment from April 16, 2008, to May 15, 2017.

Results: Data were extracted retrospectively for 74 pregnancies in 73 patients. Read More

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https://www.karger.com/Article/FullText/493462
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http://dx.doi.org/10.1159/000493462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381873PMC
February 2019
9 Reads

[Chinese expert-based consensus for methotrexate in rheumatic diseases].

Authors:

Zhonghua Nei Ke Za Zhi 2018 Oct;57(10):719-722

To establish the experts consensus on the use of methotrexate in the treatment of rheumatic diseases. A consensus development panel was established. The panel of consensus was composed of 45 experts in rheumatology from the group of Chinese Association of Rheumatology and Immunology Physicians. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2018.10.005DOI Listing
October 2018
6 Reads

Thrombotic Microangiopathies with Rheumatologic Involvement.

Rheum Dis Clin North Am 2018 11 7;44(4):635-649. Epub 2018 Sep 7.

Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, 2150 Pennsylvania Avenue, Washington, DC 20037, USA. Electronic address:

Thrombotic microangiopathies are heterogeneous disorders characterized by microangiopathic hemolytic anemia with thrombocytopenia and renal injury. There are a variety of causes, including metabolic disorders, infections, medications, complement disorders, pregnancy, malignancy, and autoimmune disorders. This review focuses on renal thrombotic microangiopathy in the setting of rheumatologic diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0889857X183006
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http://dx.doi.org/10.1016/j.rdc.2018.06.010DOI Listing
November 2018
40 Reads

Sonography of active rheumatoid arthritis during pregnancy: a case report and literature review.

Radiol Case Rep 2018 Dec 20;13(6):1233-1237. Epub 2018 Sep 20.

Division of Musculoskeletal Radiology, Department of Radiology, 200 1st Street SW, Rochester, MN 55905.

Disease activity in rheumatoid arthritis usually subsides in pregnancy, however a subset of patients have worsened symptoms with joint pain and swelling. Monitoring and mitigating disease activity in pregnancy is important for preventing deforming structural changes which can affect the ability of the patient to care for themselves and the newborn. Ultrasound is a safe and low-cost imaging modality for detecting active changes from an inflammatory arthritis, which can help guide management. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148827PMC
December 2018
4 Reads

High-throughput Serum -Glycomics: Method Comparison and Application to Study Rheumatoid Arthritis and Pregnancy-associated Changes.

Mol Cell Proteomics 2019 Jan 21;18(1):3-15. Epub 2018 Sep 21.

From the ‡Center for Proteomics and Metabolomics.

-Glycosylation is a fundamentally important protein modification with a major impact on glycoprotein characteristics such as serum half-life and receptor interaction. More than half of the proteins in human serum are glycosylated, and the relative abundances of protein glycoforms often reflect alterations in health and disease. Several analytical methods are currently capable of analyzing the total serum -glycosylation in a high-throughput manner. Read More

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http://dx.doi.org/10.1074/mcp.RA117.000454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317482PMC
January 2019
27 Reads

Role of periodontal therapy in management of common complex systemic diseases and conditions: An update.

Periodontol 2000 2018 10;78(1):212-226

Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.

The goal of this review is to summarize the results of randomized trials reported since 2010 that assessed the effect of periodontal interventions on at least one systemic outcome in human subjects of any age, gender or ethnicity. Oral outcome measures included gingivitis, pocket depth, clinical attachment loss and/or radiographic bone loss and oral hygiene indices. Studies were excluded if the trial was not completed or if treatment was not randomized. Read More

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http://dx.doi.org/10.1111/prd.12226DOI Listing
October 2018
3 Reads

Pregnancy outcomes in women with rheumatoid arthritis: a retrospective population-based cohort study.

J Matern Fetal Neonatal Med 2018 Sep 6:1-7. Epub 2018 Sep 6.

a Department of Obstetrics and Gynecology , Jewish General Hospital, McGill University Montreal , Montreal , Canada.

Purpose: To assess if pregnancies in women with rheumatoid arthritis (RA) are at a higher risk for adverse maternal and neonatal outcomes.

Materials And Methods: A retrospective cohort study was carried out using the Healthcare Cost and Utilization Project - National Inpatient Sample (HCUP-NIS) from the USA. All births that took place from 2004 to 2013 were identified and women were classified as having RA or not on the basis of ICD-9 coding. Read More

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http://dx.doi.org/10.1080/14767058.2018.1498835DOI Listing
September 2018
6 Reads

Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study.

Osteoporos Int 2019 Jan 31;30(1):221-229. Epub 2018 Aug 31.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Sud, Department of Rheumatology, Hôpital Bicêtre Université Paris-Sud, INSERM U1184, 78 rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.

We analyzed women and newborn outcome after maternal exposure to BPs. BPs have no teratogenic effect on the 36 analyzed pregnancies compared to unexposed controls matched on women underlying diseases (either systemic disease, either "bone" disease) but some outcome differed: neonatal complications rate in systemic diseases and live birth rate in bone diseases).

Introduction: The effect of bisphosphonates (BPs) during pregnancy remains unclear. Read More

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http://dx.doi.org/10.1007/s00198-018-4672-9DOI Listing
January 2019
3 Reads

Factors associated with preterm delivery among women with rheumatoid arthritis and juvenile idiopathic arthritis.

Arthritis Care Res (Hoboken) 2018 Aug 21. Epub 2018 Aug 21.

Departments of Pediatrics and Family Medicine and Public Health, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093.

Objective: Pregnant women with inflammatory arthritis may be at increased risk for preterm delivery (PTD), yet it is unclear what drives this risk. This prospective cohort study of pregnant women with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), or healthier comparison women analyzed the independent effects of maternal disease activity, medication use, and comorbid pregnancy conditions on PTD risk.

Methods: Women were enrolled before 19 weeks' completed gestation as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project. Read More

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http://dx.doi.org/10.1002/acr.23730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384155PMC
August 2018
10 Reads

Postpartum Depression and Subsequent Autoimmune Diseases in Taiwan.

Int J Environ Res Public Health 2018 08 20;15(8). Epub 2018 Aug 20.

Department of Obstetrics & Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Postpartum depression (PPD) is one of the most common examples of postnatal morbidity, but the subsequent risks of autoimmune diseases in patients with PPD have yet to be fully investigated. This nationwide population-based study utilized data of the National Health Insurance Research Database of Taiwan for the period from 1996 to 2013. In total, 45,451 women with primiparity were identified. Read More

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http://dx.doi.org/10.3390/ijerph15081783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121646PMC
August 2018
14 Reads

Autoimmunity in 2017.

Authors:
Carlo Selmi

Clin Rev Allergy Immunol 2018 Dec;55(3):239-253

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, via A. Manzoni 56, 20089 Rozzano, Milan, Italy.

The number of peer-reviewed articles published during the 2017 solar year and retrieved using the "autoimmunity" key word increased significantly compared to 2016 while maintaining a stable share within the immunology field, following years with alternated fortunes. A detailed arbitrary analysis of the published articles in leading immunology and autoimmunity journals provides a privileged viewpoint on the current trends of research from both basic and clinical studies. Indeed, we are observing that major steps forward are found for rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, among others. Read More

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http://dx.doi.org/10.1007/s12016-018-8699-7DOI Listing
December 2018
25 Reads

Drugs for rheumatoid arthritis.

Authors:

Med Lett Drugs Ther 2018 07;60(1552):123-128

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July 2018
26 Reads

Baricitinib (olumiant) for rheumatoid arthritis.

Authors:

Med Lett Drugs Ther 2018 07;60(1551):120-121

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July 2018
21 Reads

Treatment of chronic inflammatory rheumatism by biotherapy in Gabon : eligibility and follow-up of the first 8 patients in sub-Saharan Africa.

Med Sante Trop 2018 May;28(2):197-200

Université des sciences de la santé, Département de médecine interne, CHU de Libreville, 34000 Libreville, Gabon.

Objective: to clarify the eligibility criteria for biotherapies in patients with chronic inflammatory rheumatism (CIR) in sub-Saharan Africa and to describe the characteristics of the first 8 patients treated with biotherapy in Gabon.

Materials And Methods: Patients who responded inadequately to treatments by cDMARDs (EULAR criteria) had a face-to-face interview to inform them about and obtain their consent to biotherapy for at least 3 months, with details of the cost and side effects of each available biotherapy and a certificate of "necessity of biotherapy". The inclusion and follow-up of patients took place in the outpatient rheumatology consultations at the University Hospital of Libreville (Gabon) between January 2010 and December 2016. Read More

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http://dx.doi.org/10.1684/mst.2018.0781DOI Listing
May 2018
18 Reads

Outcomes of Pregnancies With Maternal/Paternal Exposure in the Tofacitinib Safety Databases for Ulcerative Colitis.

Inflamm Bowel Dis 2018 Nov;24(12):2494-2500

Department of Gastroenterology and Hepatology, Charité Medical Center Virchow Hospital, and Medical School of the Humboldt University of Berlin, Berlin, Germany.

Background: Active inflammatory bowel disease increases the risk of adverse pregnancy outcomes. Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). As a small molecule, tofacitinib is likely to cross the placental barrier; however, information on the effects of tofacitinib on pregnancy outcomes is limited. Read More

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http://dx.doi.org/10.1093/ibd/izy160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262193PMC
November 2018
68 Reads

Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults.

BMC Infect Dis 2018 07 4;18(1):302. Epub 2018 Jul 4.

Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d'Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Descartes, Paris, France.

Background: To describe extra-haematological manifestations associated with human parvovirus B19 (HPV-B19) infection.

Methods: We conducted a nationwide multicentre study to retrospectively describe the characteristics and outcome of extra-haematological manifestations in French adults.

Results: Data from 25 patients followed from 2001 to 2016 were analysed. Read More

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http://dx.doi.org/10.1186/s12879-018-3227-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033229PMC
July 2018
34 Reads

[In-label treatment of inflammatory joint diseases].

Authors:
C Kneitz C Fiehn

Z Rheumatol 2018 Sep;77(7):559-568

Praxis für Rheumatologie, Tätigkeitsschwerpunkt Klinische Immunologie und Belegarzteinheit der ViDia-Kliniken Karlsruhe, Medical Center Baden-Baden, Baden-Baden, Deutschland.

The correct use of therapeutic agents in accordance with their approved label is a requirement for a safe therapy and is often linked to the possibility of reimbursement; however, the use of drugs outside the label approval (off-label treatment) is a commonly used practice in rheumatology. This occurs because sufficient clinical trials are often lacking, particularly for rare diseases. This overview gives an insight into the correct use of disease-modifying antirheumatic drugs (DMARDs). Read More

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http://dx.doi.org/10.1007/s00393-018-0498-2DOI Listing
September 2018
3 Reads

Maternal and Fetal Outcomes in a Cohort of Patients Exposed to Tumor Necrosis Factor Inhibitors throughout Pregnancy.

J Rheumatol 2018 Aug 1;45(8):1109-1115. Epub 2018 Jul 1.

From the Department of Allergy and Immunology, McGill University, Montreal, Quebec; TRIO Fertility; Department of Obstetrics and Gynaecology, University of Toronto; Division of Rheumatology, Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Objective: Tumor necrosis factor inhibitors (TNFi) are increasingly used in pregnancy but are frequently withheld in the second or third trimesters. We evaluated the maternal and fetal outcomes of women who continued their TNFi throughout pregnancy compared to women who interrupted TNFi during pregnancy.

Methods: We retrospectively analyzed the outcomes of women seen in clinic with rheumatoid arthritis (RA), psoriatic arthritis, juvenile idiopathic arthritis (JIA), or ankylosing spondylitis, who were exposed to TNFi during pregnancy. Read More

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http://dx.doi.org/10.3899/jrheum.171152DOI Listing
August 2018
10 Reads

The Influence of LPS-Induced Maternal Inflammation on Postnatal Collagen-Induced Arthritis.

Inflammation 2018 Oct;41(5):1842-1851

Division of Clinical Nutrition, Department of Food and Nutrition, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo, 112-8681, Japan.

Maternal health and nutritional status influence offspring health and the diseases that may develop in them. The effects of maternal inflammation on offspring from the perspective of the inflammatory response and immune changes are not fully understood. We hypothesized that maternal inflammation modulates immune and metabolic functions, affecting the pathophysiology of inflammatory diseases in offspring. Read More

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http://dx.doi.org/10.1007/s10753-018-0827-2DOI Listing
October 2018
5 Reads

[The value of ultrasonic elastography in diagnosis of salivary gland lesions in patients with Sjogren's syndrome].

Shanghai Kou Qiang Yi Xue 2018 Feb;27(1):73-78

Department of Ultrasound, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China.

Purpose: The present study was aimed to clinically evaluate transitional treatment of pulpitis during pregnancy.

Methods: Sixty pregnant women with pulpitis were divided into the first, second and third trimester. They were anesthetized locally using STA system combined with psychological intervention during treatment. Read More

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February 2018
1 Read