1,938 results match your criteria Rheumatoid Arthritis and Pregnancy


Active counselling and well-controlled disease result in a higher percentage of women with rheumatoid arthritis that breast feed: results from the PreCARA study.

RMD Open 2022 Jun;8(2)

Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands.

Objectives: Previous research has demonstrated that patients with rheumatoid arthritis (RA) are less likely to breast feed their offspring. Treatment options for RA during lactation have expanded and the importance of counselling is recognised. The aim of the current research was to study breast feeding among women with RA who benefit from these developments. Read More

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Risk factors for adverse pregnancy outcomes in women with rheumatoid arthritis and follow-up of their offspring.

Clin Rheumatol 2022 Jun 13. Epub 2022 Jun 13.

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.

Objective: To explore the risk factors for adverse pregnancy outcomes (APOs) in women with rheumatoid arthritis (RA) and the influence on their offspring health.

Methods: Pregnant women with RA (n = 67) who were hospitalized in the Department of Obstetrics, Peking University People's Hospital between January 2007 and September 2021 were included in this study. Participants were evaluated at least once in each trimester and postpartum. Read More

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Association Between History of Gestational Diabetes Mellitus and the Risk of Arthritis in Women.

Front Public Health 2022 27;10:878845. Epub 2022 May 27.

Department of Obstetrics and Gynecology, The First People's Hospital of Kunshan Affiliated With Jiangsu University, Suzhou, China.

Objective: The association between gestational diabetes mellitus (GDM) and the risk of arthritis has not been reported. GDM increases the risk of long-term complications including diabetes and metabolic syndrome that are positively associated with the risk of arthritis. This study aimed to explore the association between GDM and the risk of arthritis. Read More

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Study of Cardiovascular Involvement in Rheumatoid Arthritis and it's Correlation with Severity of Disease.

Authors:
Sachin M La Gauri

J Assoc Physicians India 2022 Apr;70(4):11-12

SP Medical College, Bikaner.

Rheumatoid arthritis is a chronic systemic disease of unknown ethology characterised by persistent inflammatory synovitis usually affecting peripheral joints with symmetric distribution. Most common cause of death in RA is cardiovascular disease and pericarditis is the most common form of cardiac involvement. Valvular disorders, coronary vasculitis and ventricular diastolic dysfunction can be seen. Read More

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Association of Maternal Autoimmune Diseases With Risk of Mental Disorders in Offspring in Denmark.

JAMA Netw Open 2022 04 1;5(4):e227503. Epub 2022 Apr 1.

Department of Clinical Medicine, Department of Clinical Epidemiology, Aarhus University, Denmark.

Importance: Maternal immune activation during pregnancy is associated with increased risks of several mental disorders in offspring during childhood, but little is known about how maternal autoimmune diseases during pregnancy are associated with mental health in offspring during and after childhood.

Objective: To investigate the association between maternal autoimmune diseases before childbirth and risk of mental disorders among offspring up to early adulthood.

Design, Setting, And Participants: This population-based nationwide cohort study used data from Danish national registers on singletons born in Denmark from 1978 to 2015 with up to 38 years of follow-up. Read More

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COVID-19 Mortality in Patients with Rheumatic Diseases: A Real Concern.

Curr Rheumatol Rev 2022 Apr 12. Epub 2022 Apr 12.

Infectious Diseases Unit, Royal Hospital, Muscat, Oman.

Background: Coronavirus disease 2019 (COVID 19) is a worldwide pandemic that has devastated the world in a way that has not been witnessed since the Spanish Flu in 1918. In this study, we aim to investigate the outcomes of patients with rheumatic diseases infected with COVID19 in Oman.

Methods: A multi-center retrospective cohort study included patients with underlying rheumatological conditions and COVID-19 infection. Read More

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Pregnancy and Management in Women with Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Obstetric Antiphospholipid Syndrome.

Rheum Dis Clin North Am 2022 05;48(2):523-535

UT Southwestern Medical Center, 2001 Inwood Road, Dallas, TX 75390, USA. Electronic address:

Management of women with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and obstetric antiphospholipid syndrome (APS) during pregnancy presents unique clinical challenges. Women with both RA and SLE can have disease flares during pregnancy, leading to pregnancy complications, such as preeclampsia, small-for-gestational-age infants, and preterm delivery. Disease should be under control prior to conception. Read More

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TMT-Based Quantitative Proteomics Analysis of Synovial Fluid-Derived Exosomes in Inflammatory Arthritis.

Front Immunol 2022 11;13:800902. Epub 2022 Mar 11.

Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China.

Objectives: To compare the proteomics of synovial fluid (SF)-derived exosomes in rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), gout, and osteoarthritis (OA) patients.

Methods: Exosomes were separated from SF by the Exoquick kit combined ultracentrifugation method. Tandem mass tags (TMT)-labeled liquid chromatography mass spectrometry (LC-MS/MS) technology was used to analyze the proteomics of SF-derived exosomes. Read More

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Rheumatic Diseases in Reproductive Age-the Possibilities and the Risks.

Reprod Sci 2022 Mar 31. Epub 2022 Mar 31.

Department of Rheumatology, Rehabilitation and Internal Diseases, Poznan University of Medical Sciences, 28 Czerwca Street 135/147, 60-545, Poznań, Poland.

The most common systemic connective tissue diseases (CTD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis (SSc), and Sjögren's syndrome (SjS), affect many women of reproductive age. These diseases may strongly impact the course of pregnancy and increase the risk factors of incompatibility. A literature search was done on MEDLINE, PubMed, and Google Scholar in 2011-2021. Read More

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Biological and Methotrexate Survival after Pregnancy in Patients With a Rheumatic Disease.

Front Pharmacol 2022 9;13:826034. Epub 2022 Mar 9.

Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands.

Patients with a rheumatic disease who discontinue their disease-modifying anti-rheumatic drug (DMARD) due to pregnancy often wonder if treatment will be as effective after pregnancy. This study investigates the effect of a temporary discontinuation of DMARDs due to pregnancy on the effectiveness of the same DMARD postpartum in patients with a rheumatic disease. Pregnant, rheumatic patients were derived from the Preconceptional Counseling in Active Rheumatoid Arthritis (PreCARA) cohort. Read More

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Evaluation of Ovarian Reserve in Women With Rheumatoid Arthritis.

J Family Reprod Health 2021 Dec;15(4):236-241

Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Dr. José Eleuterio Gonzalez University Hospital, Autonomous University of Nuevo Leon, Monterrey, Mexico.

Subfertility is commonly observed in patients with rheumatoid arthritis (RA). Although the causes are not well established, the alteration of the ovarian reserve is thought to contribute to the lower chances of pregnancy. This cross-sectional study aimed to evaluate the ovarian reserve in patients with RA. Read More

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December 2021

LC-MS/MS-Based Serum Protein Profiling for Identification of Candidate Biomarkers in Pakistani Rheumatoid Arthritis Patients.

Life (Basel) 2022 Mar 21;12(3). Epub 2022 Mar 21.

Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK.

Rheumatoid arthritis is an autoimmune disorder of complex disease etiology. Currently available serological diagnostic markers lack in terms of sensitivity and specificity and thus additional biomarkers are warranted for early disease diagnosis and management. We aimed to screen and compare serum proteome profiles of rheumatoid arthritis serotypes with healthy controls in the Pakistani population for identification of potential disease biomarkers. Read More

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Drug Treatment Algorithm and Recommendations from the 2020 update of the Japan College of Rheumatology Clinical Practice Guidelines for the Management of Rheumatoid Arthritis-Secondary Publication.

Mod Rheumatol 2022 Mar 16. Epub 2022 Mar 16.

Department of Internal Medicine, Division of Rheumatology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Objective: The aim of this study was to update the Japan College of Rheumatology (JCR) clinical practice guidelines (CPG) for the management of rheumatoid arthritis (RA) (JCR CPG for RA) according to recent changes in the medical environment in Japan. This article is a digest version of the guidance.

Methods: We used the Grading of Recommendations, Assessment, Development, and Evaluation method to update the 2014 JCR CPG for RA. Read More

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Non-Drug and Surgical Treatment Algorithm and Recommendations for the 2020 Update of the Japan College of Rheumatology Clinical Practice Guidelines for the Management of Rheumatoid Arthritis - Secondary Publication.

Mod Rheumatol 2022 Mar 16. Epub 2022 Mar 16.

Department of Internal Medicine, Division of Rheumatology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Objectives: The aim of this study was to update the Japan College of Rheumatology (JCR) clinical practice guidelines (CPGs) for the management of rheumatoid arthritis (RA) and prepare an algorithm for non-drug and surgical treatments. This article is a digest version of the guidelines.

Methods: The Japanese Ministry of Health, Labour and Welfare's research group, in collaboration with the JCR, used the Grading of Recommendations, Assessment, Development, and Evaluation method to update the 2014 JCR CPG for RA. Read More

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Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study.

Nutrients 2022 Jan 20;14(3). Epub 2022 Jan 20.

The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark.

Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood.

Methods: This case-cohort study obtained data from Danish registers and biobanks. Read More

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January 2022

A systematic review of live vaccine outcomes in infants exposed to biologic disease modifying anti-rheumatic medications (DMARDs) in-utero.

Rheumatology (Oxford) 2022 Mar 8. Epub 2022 Mar 8.

Rheumatology Department, University College London Hospital, London, UK.

Objectives: Transplacental passage of certain biologic- and targeted synthetic DMARDs leads to detectable levels in the neonate, which may impact on the safety of live vaccines. Guidelines advise delaying live vaccine administration in biologic exposed infants until they are 7 months old.

Methods: A systematic review of Embase, Medline and Cochrane identified live vaccine outcomes in infants exposed to biologic or targeted synthetic DMARDs in-utero. Read More

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Pregnant women with immune mediated inflammatory diseases who discontinue biologics have higher rates of disease flare.

Arch Gynecol Obstet 2022 Mar 6. Epub 2022 Mar 6.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Background And Aims: Biologic agents have revolutionized treatment of immune mediated inflammatory diseases (IMIDs). However, despite the benefits of treatment, there is limited data on its use during pregnancy leading to significant variation in practices. We evaluated maternal, neonatal, and disease-related outcomes in pregnant women with IMIDs, comparing those with biologic exposure during pregnancy to those without exposure. Read More

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Beyond Systemic Lupus Erythematosus and Anti-Phospholipid Syndrome: The Relevance of Complement From Pathogenesis to Pregnancy Outcome in Other Systemic Rheumatologic Diseases.

Front Pharmacol 2022 15;13:841785. Epub 2022 Feb 15.

Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan, Milan, Italy.

Evidence about the relevance of the complement system, a highly conserved constituent of the innate immunity response that orchestrates the elimination of pathogens and the inflammatory processes, has been recently accumulated in many different rheumatologic conditions. In rheumatoid arthritis, complement, mainly the classical pathway, contributes to tissue damage especially in seropositive subjects, with complement activation occurring in the joint. Data about complement pathways in psoriatic arthritis are dated and poorly consistent; among patients with Sjögren syndrome, hypocomplementemia exerts a prognostic role, identifying patients at risk of extra-glandular manifestations. Read More

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February 2022

Progesterone Inhibits the Establishment of Activation-Associated Chromatin During T1 Differentiation.

Front Immunol 2022 2;13:835625. Epub 2022 Feb 2.

Bioinformatics, Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden.

T1-mediated diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) improve during pregnancy, coinciding with increasing levels of the pregnancy hormone progesterone (P4), highlighting P4 as a potential mediator of this immunomodulation. Here, we performed detailed characterization of how P4 affects the chromatin and transcriptomic landscape during early human T1 differentiation, utilizing both ATAC-seq and RNA-seq. Time series analysis of the earlier events (0. Read More

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Modulatory role of prenatal alcohol exposure and adolescent stress on the response to arthritis challenge in adult female rats.

EBioMedicine 2022 Mar 17;77:103876. Epub 2022 Feb 17.

Department of Cellular and Physiological Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.

Background: There are known environmental risk factors associated with rheumatoid arthritis; however, less is known regarding how the prenatal environment impacts later-life risk for rheumatoid arthritis. Based on preliminary clinical data suggesting that individuals with fetal alcohol spectrum disorder (FASD) are at higher risk for autoimmune disorders, this study investigated the modulatory impact of prenatal alcohol exposure (PAE) on the inflammatory disease profile in an adjuvant-induced arthritis rat model.

Methods: Pregnant rats received liquid ethanol or control diet throughout gestation. Read More

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Economic impact of obstetric events on women of reproductive age living with psoriatic arthritis, rheumatoid arthritis, axial spondyloarthritis and psoriasis in Spain.

Reumatol Clin (Engl Ed) 2022 Feb 7;18(2):105-113. Epub 2021 May 7.

Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address:

Objective: To estimate the annual cost associated with obstetric events in women of reproductive age with immune-mediated inflammatory diseases, from the perspective of the National Healthcare System.

Methods: A cost-analysis was developed to estimate the impact associated with obstetric events in women of reproductive age with psoriasis (PSO), psoriatic arthritis (PsA), rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA). The analysis considered complications during fertility and conception, in pregnancy and in the postpartum. Read More

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February 2022

Women with Rheumatoid Arthritis have similar rates of postpartum maternal outcomes compared to women without autoimmune disease.

Semin Arthritis Rheum 2022 04 2;53:151975. Epub 2022 Feb 2.

Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, T-3113 Medical Center North, Nashville, TN 37232-2681 USA. Electronic address:

Objective: Limited data exist on the effect of rheumatoid arthritis (RA) on maternal postpartum outcomes. Using a real-world, electronic health record (EHR) cohort, we assessed maternal postpartum outcomes in RA.

Methods: In a large, de-identified EHR, we identified possible RA deliveries using ≥1 delivery ICD-9 or ICD-10-CM codes and a validated RA algorithm. Read More

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The multifaced role of HtrA1 in the development of joint and skeletal disorders.

Bone 2022 04 5;157:116350. Epub 2022 Feb 5.

Department of Clinical and Molecular Sciences (DISCLIMO), Università Politecnica delle Marche, Via Tronto 10/a, Ancona 60126, Italy.

HtrA1 (High temperature requirement A1) family proteins include four members, widely conserved from prokaryotes to eukaryotes, named HtrA1, HtrA2, HtrA3 and HtrA4. HtrA1 is a serine protease involved in a variety of biological functions regulating many signaling pathways degrading specific components and playing key roles in many human diseases such as neurodegenerative disorders, pregnancy complications and cancer. Due to its role in the breakdown of many ExtraCellular Matrix (ECM) components of articular cartilage such as fibronectin, decorin and aggrecan, HtrA1 encouraged many researches on studying its role in several skeletal diseases (SDs). Read More

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Carbamylation of β2-GPI generates new autoantigens for Antiphospholipid Syndrome: a new tool for diagnosis of "seronegative" patients.

Rheumatology (Oxford) 2022 Feb 2. Epub 2022 Feb 2.

Department of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.

Objectives: Antiphospholipid syndrome (APS) is a prothrombotic condition defined by recurrent thrombosis, pregnancy complications and circulating antiphospholipid antibodies (aPL), including anti-β2-Glycoprotein I (β2-GPI). In clinical practice it is possible to find patients with APS persistently negative for the aPL tests according to Sydney criteria ("seronegative APS", SN-APS). Recently, several autoimmune responses have been described as a consequence of post-translational modifications of their target autoantigens. Read More

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February 2022

The effectiveness of decision aids for pregnancy related decision-making in women with pre-pregnancy morbidity; systematic review and meta-analysis.

BMC Pregnancy Childbirth 2022 Jan 29;22(1):81. Epub 2022 Jan 29.

Department of Women and Children's Health, King's College London, Westminster Bridge Road, London, UK.

Introduction: Women with pre-existing morbidity arising from medical conditions or previous caesarean section are at higher risk of adverse pregnancy outcomes compared to women without such morbidity. Women often face complex pregnancy-related decision-making that may be characterized by conflicting maternal and perinatal priorities. The aim of this systematic review and meta-analysis was to assess randomised controlled trials of decision aids to evaluate whether they are effective at reducing decisional conflict scores and to evaluate what type of decision aids are most effective for women with pre-existing morbidity in pregnancy. Read More

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January 2022

Differences in the Association Between Oral Glucocorticoids and Risk of Preterm Birth by Data Source: Reconciling the Results.

Arthritis Care Res (Hoboken) 2022 Jan 28. Epub 2022 Jan 28.

University of California San Diego, La Jolla.

Objective: To investigate causes of discrepancies in the association between early pregnancy oral glucocorticoid (OGC) use and preterm birth risk among women with rheumatoid arthritis (RA) in health care utilization data from California Medicaid (Medi-Cal) and the prospective cohort MotherToBaby Pregnancy Studies.

Methods: Separately, we estimated risk ratios (RRs) between OGC exposure before gestational day 140 and preterm birth risk in data from Medi-Cal (2007-2013; n = 844) and MotherToBaby (2003-2014; n = 528). We explored differences in socioeconomic status, OGC dose distribution, exposure misclassification, and confounding by RA severity across the data sources. Read More

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January 2022

Expanded Table: Some biologic drugs and JAK inhibitors for rheumatoid arthritis.

Authors:

Med Lett Drugs Ther 2021 Nov 15;63(1637):e187-e189. Epub 2021 Nov 15.

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November 2021

Expanded Table: Some conventional DMARDs for rheumatoid arthritis.

Authors:

Med Lett Drugs Ther 2021 Nov 15;63(1637):e185-e186. Epub 2021 Nov 15.

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November 2021

Drugs for rheumatoid arthritis.

Authors:

Med Lett Drugs Ther 2021 11;63(1637):177-184

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November 2021

"The medications are the decision-makers…" Making reproductive and medication use decisions among female patients with rheumatoid arthritis: a constructivist grounded theory.

Arthritis Res Ther 2022 01 22;24(1):31. Epub 2022 Jan 22.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

Objective: To examine how female patients with RA form decisions about having children, pregnancy, and medication use.

Methods: We employed a constructivist grounded theory design and recruited female participants who are 18 years or older, have a rheumatologist-confirmed RA diagnosis, live in Canada, and are able to communicate in English or French. We collected data through semi-structured individual and focus group interviews using telephone or video conferencing technology. Read More

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January 2022