1,777 results match your criteria Rheumatoid Arthritis and Pregnancy


Determination of the Role of Fusobacterium Nucleatum in the Pathogenesis in and Out the Mouth.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2020 Jun;41(1):87-99

"Dr. Spasovski"Skopje, R.N. Macedonia.

Introduction: One of the most important types of microorganisms in the oral cavity in both healthy and non-healthy individuals is Fusobacterium nucleatum. Although present as a normal resident in the oral cavity, this Gram-negative pathogen is dominant in periodontal disease and it is involved in many invasive infections in the population, acute and chronic inflammatory conditions, as well as many adverse events with a fatal outcome.

Aim: To determine the role of F. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/prilozi-2020-0026DOI Listing

Fertility and sexuality of women with inflammatory arthritis.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 2;251:199-205. Epub 2020 Jun 2.

Department of Reproductive Medicine, Toulouse University Hospital, France; Groupe de Recherche en Fertilité Humaine (Human Fertility Research Group) EA 3694, Université Paul Sabatier, Toulouse, France. Electronic address:

Objective: This study aimed to evaluate the impact of the four main types of inflammatory arthritis (rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PA), juvenile chronic arthritis (JCA)) on female fertility.

Design: We performed a monocentric observational study, which took place in the Reproductive Medicine Department and the Rheumatology Department of the Toulouse University Hospital. An anonymous questionnaire was sent to patients aged 18-50 with RA, AS, PA or JCA who were diagnosed before the age of 40 and who consented to participate in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2020.05.068DOI Listing

Revisiting hydroxychloroquine and chloroquine for patients with chronic immunity-mediated inflammatory rheumatic diseases.

Adv Rheumatol 2020 06 9;60(1):32. Epub 2020 Jun 9.

Pontifícia Universidade Católica de Campinas, Campinas, Brazil.

Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. Rheumatologists have been using antimalarials to manage patients with chronic immune-mediated inflammatory rheumatic diseases for decades. It is an appropriate time to review their immunomodulatory and anti-inflammatory mechanisms impact on disease activity and survival of systemic lupus erythematosus patient, including antiplatelet effect, metabolic and lipid benefits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s42358-020-00134-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282202PMC

Drug discontinuation in pregnant women with psoriasis: The PSO-MOTHER cohort study.

Pharmacoepidemiol Drug Saf 2020 Jun 5. Epub 2020 Jun 5.

Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.

Purpose: To analyse the drug use pattern in women with psoriasis before, during and after pregnancy.

Methods: All children born (2009-2016) in a central Italian region (Lazio) to mothers with a diagnosis of psoriasis were identified. Drug use patterns (biologicals, systemic, and topical), and discontinuation and switching of drug therapies before, during, and after pregnancy were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pds.5030DOI Listing

Rheumatology-led pregnancy clinic: enhancing the care of women with rheumatic diseases during pregnancy.

Clin Rheumatol 2020 Jun 3. Epub 2020 Jun 3.

Rheumatology Department, North Middlesex University Hospital, London, UK.

The autoimmune rheumatic diseases have a clear predilection for women. Consequently, issues regarding family planning and pregnancy are a vital component of the management of these patients. Not only does pregnancy by itself causes physiologic/immunologic changes that impact disease activity but also women living with inflammatory arthritic conditions face the additional challenges of reduced fecundity and worsened pregnancy outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10067-020-05173-6DOI Listing

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jun 3;21(1):466. Epub 2020 Jun 3.

Clinical Pharmacology Department, Clinical Trial Unit, La Paz University Hospital - IdiPAZ, Paseo de la Castellana, 261, 28046, Madrid, Spain.

Objectives: Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-020-04436-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267766PMC

Fertility and infertility implications in rheumatoid arthritis; state of the art.

Inflamm Res 2020 Aug 26;69(8):721-729. Epub 2020 May 26.

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: A bulk of investigations imply that women with rheumatoid arthritis (RA) deliver fewer children in comparison to healthy women.

Purpose: This review article attempts to clarify the involvement of infertility-related issues in both RA men and women. Moreover, the effect of RA disease on the fertility quality and quantity will be discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00011-020-01362-wDOI Listing
August 2020
2.143 Impact Factor

Oral microbiome-systemic link studies: perspectives on current limitations and future artificial intelligence-based approaches.

Crit Rev Microbiol 2020 May 21:1-12. Epub 2020 May 21.

Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

In the past decade, there has been a tremendous increase in studies on the link between oral microbiome and systemic diseases. However, variations in study design and confounding variables across studies often lead to inconsistent observations. In this narrative review, we have discussed the potential influence of study design and confounding variables on the current sequencing-based oral microbiome-systemic disease link studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1040841X.2020.1766414DOI Listing

Clinical and public health implications of periodontal and systemic diseases: An overview.

Periodontol 2000 2020 Jun;83(1):7-13

ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.

Severe periodontitis is defined by extensive loss of the tooth attachment apparatus. It is the sixth most common human disease and is estimated to affect 11.2% of the global adult population, hence representing a significant healthcare, social, and economic burden. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/prd.12344DOI Listing

Minimally Invasive Open Surgical Approach and Outcomes for Carpal Tunnel Syndrome.

Sisli Etfal Hastan Tip Bul 2019 26;53(3):247-251. Epub 2019 Aug 26.

Acibadem Healthcare Group, Fulya Hospital, Neurosurgery, Istanbul, Turkey.

Objectives: The most common peripheral neuropathy is carpal tunnel syndrome. The present study aims to describe our minimally invasive open surgical approach for carpal tunnel syndrome and evaluate surgical outcomes.

Methods: We included 217 patients who were operated in our clinic for carpal tunnel syndrome by minimally invasive open surgical approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14744/SEMB.2019.94759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192267PMC

Anxiety and depression in reproductive age women with rheumatic diseases.

Rheumatol Int 2020 May 5. Epub 2020 May 5.

Rheumatology Service, Hospital Universitario "Dr. José Eleuterio Gonzalez", Universidad Autónoma de Nuevo León, Av. Gonzalitos 235 Norte, Colonia Mitras Centro, C.P 64460, Monterrey, Nuevo León, Mexico.

Women in reproductive age with rheumatic diseases (RD) are especially vulnerable for depression and anxiety which negatively impacts the pregnancy, birth, and RD. The purpose of this study is to describe the frequency of anxiety and depression symptoms employing the Hospital Anxiety and Depression Scale (HADS) in women in reproductive age. We conducted an observational, single-center, cross-sectional, and descriptive study in reproductive-age, non-pregnant women without a prior psychiatric diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-020-04591-8DOI Listing
May 2020
1.627 Impact Factor

Factors associated with time to pregnancy in women with axial spondyloarthritis: A registry-based multicenter study.

Arthritis Care Res (Hoboken) 2020 Apr 30. Epub 2020 Apr 30.

Norwegian National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olavs Hospital - Trondheim University Hospital, Trondheim, Norway.

Objective: To study time to pregnancy (TTP) and factors associated with TTP in women with axial spondyloarthritis (axSpA), compared to women with rheumatoid arthritis (RA).

Methods: We included 274 women with axSpA and 317 women with RA from the Norwegian nationwide registry RevNatus. For all the women, we had retrospectively collected data on TTP, and a subgroup also had prospectively collected data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acr.24233DOI Listing

Rheumatoid arthritis in pregnancy and school performance in offspring.

Arthritis Care Res (Hoboken) 2020 Apr 27. Epub 2020 Apr 27.

Department of Public Health, Aarhus University, Aarhus, Denmark.

Objectives: To examine the overall cognitive development of children exposed to maternal rheumatoid arthritis (RA) in utero by comparing their school test scores, to those of their peers.

Methods: Children born in Denmark 1995-2008, and listed in the National School Test Register were included (n=738,862). Children exposed to maternal RA were identified through linkage of national registers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acr.24223DOI Listing

Mechanisms determining the amelioration of rheumatoid arthritis in pregnancy: A systematic review.

Semin Arthritis Rheum 2020 Mar 19. Epub 2020 Mar 19.

Rayne Institute, University College London Centre for Rheumatology Research, University Street, London WC1E 6JF, United Kingdom. Electronic address:

Background: The phenomenon of pregnancy-induced remission of rheumatoid arthritis (RA) was first reported by Philip Hench in 1938. Despite extensive efforts, the underlying scientific basis has remained elusive. A number of different potential mechanisms have been investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semarthrit.2020.03.006DOI Listing

JAK Inhibitors: Prospects in Connective Tissue Diseases.

Clin Rev Allergy Immunol 2020 Mar 28. Epub 2020 Mar 28.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No.1 Shuaifuyuan, Beijing, 100730, China.

The dysregulation of the JAK-STAT pathway is associated with various immune disorders. Four JAK inhibitors have been approved for rheumatoid arthritis (RA), and numerous JAK inhibitors are currently being tested in phase II and III trials for the treatment of various autoimmune inflammatory diseases. In this narrative review, we elucidate the involvement of the JAK-STAT signaling pathway in the pathogenesis of connective tissue diseases (CTDs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12016-020-08786-6DOI Listing
March 2020
5.463 Impact Factor

Pregnancy and autoimmune diseases.

Authors:
Emily C Somers

Best Pract Res Clin Obstet Gynaecol 2020 Apr 14;64:3-10. Epub 2019 Nov 14.

University of Michigan Schools of Medicine & Public Health, Departments of Internal Medicine, Environmental Health Sciences and Obstetrics and Gynecology, 2800 Plymouth Rd, NCRC B14-G236, Ann Arbor, MI 48109-2800, USA. Electronic address:

Autoimmune diseases (AID) are more prevalent in women than in men, and pregnancy-related factors such as hormonal modulation and fetal microchimerism may influence the future risk of maternal AID. For women with AID, optimizing reproductive health requires a continuum of multidisciplinary care that initiates well before the desire for pregnancy is articulated. Family planning is essential so that pregnancy can be timed when disease is stable and to allow for appropriate medication adjustments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpobgyn.2019.11.004DOI Listing

Sexual function and reproduction can be impaired in men with rheumatic diseases: A systematic review.

Semin Arthritis Rheum 2020 06 14;50(3):557-573. Epub 2020 Feb 14.

Department of Rheumatology, Erasmus MC, University Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, the Netherlands.

Background: Information about the possible effect of rheumatic diseases on male sexual function and reproduction (sexual health) is scarce and difficult to summarize. Factors known to impair sexual health, such as inflammation, medication use and hypogonadism can be present in a significant proportion of male patients with rheumatic diseases.

Objectives: The objective of our study was to systematically review the literature for the influence of paternal rheumatic disease on sexual health, such as sexual function, reproductive hormones, male fertility, pregnancy and offspring outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semarthrit.2020.02.002DOI Listing

Peripartum issues in the inflammatory arthritis patient: A survey of the RAPPORT registry.

Sci Rep 2020 Feb 28;10(1):3733. Epub 2020 Feb 28.

Division of Rheumatology, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Alberta, Canada.

Childbearing women with rheumatoid (RA) and psoriatic arthritis (PsA) have significant peripartum issues. A retrospective anonymous RedCAP survey of peripartum period in females with RA/PsA in the RAPPORT registry was performed. Completed analyses included descriptive statistics, Chi-square and Fisher's exact test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-60451-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048931PMC
February 2020

Baricitinib exposure during pregnancy in rheumatoid arthritis.

Ther Adv Musculoskelet Dis 2020 3;12:1759720X19899296. Epub 2020 Feb 3.

Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.

We here describe the case of a 43-year-old White woman who was diagnosed with rheumatoid arthritis treated with anti-tumour necrosis factor drugs that caused an adverse drug reaction. The objective of this study was to describe the outcome of a pregnancy under baricitinib, a JAK-inhibitor drug, in a woman affected by rheumatoid arthritis. Scant data are available about the safety of JAK inhibitors during pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1759720X19899296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997965PMC
February 2020

Publisher Correction: Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity.

Nat Rev Rheumatol 2020 Mar;16(3):184

Department of Rheumatology, Immunology, and Allergology, University Hospital and University of Bern, Bern, Switzerland.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41584-020-0394-4DOI Listing

Epidemiology of Antiphospholipid Syndrome in Korea: a Nationwide Population-based Study.

J Korean Med Sci 2020 Feb 10;35(5):e35. Epub 2020 Feb 10.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and venous thrombosis or pregnancy morbidity in patients with persistent antiphospholipid antibodies. However, nationwide population-based epidemiology studies regarding APS are still unavailable.

Methods: We analyzed claims data extracted from the Korean Health Insurance and Review Agency (HIRA) covering more than 52 million Koreans, between January 1, 2008, and December 31, 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3346/jkms.2020.35.e35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008065PMC
February 2020

Acquired hemophilia.

Gac Med Mex 2020 ;156(1):67-77

Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis. Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Ciudad de México, México.

Acquired hemophilia (AH) is an autoimmune hemostatic disorder mediated by autoantibodies directed against factor VIII: C. In 52% of cases, the cause is unknown or is not associated with other pathological entities; in the rest, there are concomitant factors: lupus, rheumatoid arthritis, cancer, pregnancy, and medications. In Mexico, there is not a registry of AH, and awareness of the disease among health personnel is low. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24875/GMM.19005469DOI Listing
January 2020

Anti-TNF treatment during pregnancy and birth outcomes: A population-based study from Denmark, Finland, and Sweden.

Pharmacoepidemiol Drug Saf 2020 03 4;29(3):316-327. Epub 2020 Feb 4.

Clinical Epidemiology Division, Department of Medicine Solna, Karolinska institutet, Stockholm, Sweden.

Purpose: To study the risk of preterm birth, caesarean section, and small for gestational age after anti-tumor necrosis factor agent treatment (anti-TNF) in pregnancy.

Methods: Population-based study including women with inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and psoriasis, and their infants born 2006 to 2013 from the national health registers in Denmark, Finland, and Sweden. Women treated with anti-TNF were compared with women with nonbiologic systemic treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pds.4930DOI Listing

Biologic therapy use and pregnancy outcomes in women with immune-mediated inflammatory rheumatic diseases.

Acta Reumatol Port 2019 Oct-Dec;44(4):266-272

Hospital Garcia da Orta.

Introduction: Concerns about the side effects and interactions of biologic drugs with reproduction and pregnancy have been always an issue between experts. The safety of these therapies during conception and/or pregnancy is not fully understood. The aim of this study was to assess the exposure to biologic drugs before and/or during conception/pregnancy and the risk of adverse pregnancy outcomes in women with rheumatic diseases. Read More

View Article

Download full-text PDF

Source
February 2020

Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity.

Nat Rev Rheumatol 2020 02 13;16(2):113-122. Epub 2020 Jan 13.

Department of Rheumatology, Immunology, and Allergology, University Hospital and University of Bern, Bern, Switzerland.

During pregnancy, the fetus that grows within the maternal uterus is not rejected by the maternal immune system. To enable both tolerance towards the fetus and defence against pathogens, modifications of the maternal immune system occur during gestation. These modifications are able to bring about a natural improvement in disease activity of some autoimmune diseases, such as rheumatoid arthritis (RA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41584-019-0351-2DOI Listing
February 2020

Improved pregnancy outcome in patients with Rheumatoid Arthritis who followed an ideal clinical pathway.

Arthritis Care Res (Hoboken) 2020 Jan 7. Epub 2020 Jan 7.

Department of Medical Sciences, Rheumatology Unit, University of Ferrara, Cona (Ferrara), Italy.

Objective: Among women with rheumatoid arthritis (RA) we aimed to assess the effect of optimal management of pregnancy, on a composite outcome of miscarriage and complicated birth.

Methods: Data were extracted from healthcare databases of the Lombardy Region, Italy (2004-2013), as a part of the RECord-linkage On Rheumatic Diseases Study. Analyses included women with RA identified through copayment exemption code (ICD9-CM code 714. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acr.24116DOI Listing
January 2020

Tumefactive Demyelinating Lesions and Pregnancy.

Neurol India 2019 Nov-Dec;67(6):1519-1521

Department of Clinical Experimental Oncology, IRCCS Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.

Until now, only one gestational tumefactive demyelinating lesion (TDL) has been described. Here we report two TDL cases occurring during and after the pregnancy. A 26-year-old 6-week pregnant woman developed a 3-cm left frontotemporoparietal subcortical TDL with inhomogeneous partial enhancement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0028-3886.273654DOI Listing

Immunologic and rheumatologic aspects of recurrent pregnancy loss: have the sirens enchanted us onto the rocks?

Authors:
Zev Rosenwaks

Fertil Steril 2019 12;112(6):1000-1001

Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fertnstert.2019.10.001DOI Listing
December 2019

Infertility in women with systemic autoimmune diseases.

Best Pract Res Clin Endocrinol Metab 2019 12 2;33(6):101369. Epub 2019 Dec 2.

Department of Obstetrics and Gynecology of I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

Infertility consists by definition in" failure to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse" while the term subfertility means a delay to achieve pregnancy. Several factors can contribute to infertility or subfertility in patients with systemic autoimmune diseases. The association of systemic autoimmune conditions with endometriosis, celiac disease and thyroid autoimmunity that are well known causes of infertility and/or subfertility need to be taken in consideration when difficulties in the onset of pregnancy is reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.beem.2019.101369DOI Listing
December 2019

[Pregnancy and rheumatic diseases].

Z Rheumatol 2020 Feb;79(1):55-73

Rheumapraxis München Pasing, München, Deutschland.

Inflammatory rheumatic diseases preferentially affect women of childbearing age. Immunological alterations can have positive or negative effects on the maternal disease. Most of these women can have a successful pregnancy with careful medical and obstetric care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00393-019-00736-8DOI Listing
February 2020

Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond.

Front Immunol 2019 22;10:2739. Epub 2019 Nov 22.

Department of Basic Medical Sciences, College of Medicine, Member of QU Health, Qatar University, Doha, Qatar.

In addition to its role in calcium homeostasis and bone formation, a modulatory role of the active form of vitamin D on cells of the immune system, particularly T lymphocytes, has been described. The effects of vitamin D on the production and action of several cytokines has been intensively investigated in recent years. In this connection, deficiency of vitamin D has been associated with several autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), Hashimoto Thyroiditis (HT), and multiple sclerosis (MS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.02739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883724PMC
November 2019
4 Reads

Assisted reproductive technologies for women with rheumatic AID.

Best Pract Res Clin Obstet Gynaecol 2020 Apr 23;64:85-96. Epub 2019 Oct 23.

Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Assisted reproductive technology (ART) procedures are safe for women with rheumatic autoimmune diseases (rAID) when illness is inactive. Medications incompatible with pregnancy should be replaced with alternative pregnancy-compatible medications months before planned ART procedures to allow time to verify the substitute medication's efficacy and tolerability. Medications compatible with pregnancy should be continued, as should anticoagulation (warfarin changed to low-molecular-weight heparin) before pregnancy begins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpobgyn.2019.10.002DOI Listing

Contraceptive Use in Women of Childbearing Ability With Rheumatoid Arthritis.

J Clin Rheumatol 2019 Nov 19. Epub 2019 Nov 19.

From the Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences.

Background/objective: Rheumatoid arthritis (RA) is a complex disease that may require treatment with one or several disease-modifying antirheumatic drugs (DMARDs). Many DMARDs have potential teratogenic effects or are newer agents with limited safety data in pregnancy. This study evaluated 20 common RA medications and the rate of contraceptive prescribing and counseling patterns in women with RA of childbearing ability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000001184DOI Listing
November 2019

Current perspectives on fertility, pregnancy and childbirth in patients with Rheumatoid Arthritis.

Semin Arthritis Rheum 2019 12;49(3S):S32-S35

Department of Rheumatology, Erasmus University Medical Centre, Postbus 2040, Erasmus MC, room Na523, 3000 CA Rotterdam, the Netherlands.

Rheumatoid Arthritis (RA) is common in the reproductive age. Women with RA have an impaired fertility related to the use of certain medication and active disease. RA usually improves during pregnancy, however almost half of the patients still have active disease in third trimester. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semarthrit.2019.09.010DOI Listing
December 2019

"r/Thritis", Pregnancy, and Parenting: A Qualitative Descriptive Study of Reddit Forums to Explore Information Needs and Concerns of Women With Rheumatoid Arthritis.

ACR Open Rheumatol 2019 Oct 15;1(8):485-492. Epub 2019 Aug 15.

Collaboration for Outcomes Research and Evaluation, Vancouver, British Columbia, Canada, and Arthritis Research Canada Richmond British Columbia Canada.

Objective: Rheumatoid arthritis (RA) disproportionately affects more women than men, often striking during childbearing years. Because the Internet, particularly social media, is increasingly used by patients with chronic conditions seeking and sharing information, our objective was to conduct a qualitative descriptive study of threads on the social news website, Reddit, to understand the information needs and concerns of women with RA regarding pregnancy and parenting.

Methods: We searched threads (original posts and responses) on three subreddit sites, "r/Thritis," "r/Rheumatoid," and "r/BabyBumps," over a 10-year period between October 27, 2008, and October 27, 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acr2.11069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857968PMC
October 2019

Reduced Ovarian Function in Female Rheumatoid Arthritis Patients Trying to Conceive.

ACR Open Rheumatol 2019 Jul 4;1(5):327-335. Epub 2019 Jul 4.

Erasmus University Medical Center Rotterdam Rotterdam The Netherlands.

Objective: Subfertility, a time to pregnancy (TTP) longer than 12 months, is present in 40% of female patients with rheumatoid arthritis (RA) who are actively trying to conceive. Because patients with RA appear to reach menopause at a younger age, diminished ovarian function may explain the reduced fertility. Serum anti-Müllerian hormone (AMH) levels are the best proxy to measure ovarian function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acr2.11043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857972PMC

Pregnancy, Periods, and "The Pill": Exploring the Reproductive Experiences of Women with Inflammatory Arthritis.

ACR Open Rheumatol 2019 Apr 15;1(2):125-132. Epub 2019 Apr 15.

Duke University Medical Center Durham North Carolina.

Objective: Women with inflammatory arthritis appear to have fewer children as compared with healthy women, but few studies have assessed how patients' attitudes and decision making influence their family sizes. Little is also known about how patients experience other aspects of their reproductive lives, such as menstruation and contraception.

Methods: We partnered with ArthritisPower, a patient-powered research network, and its associated online patient community, CreakyJoints, to create and disseminate a survey among female members aged 18-50 years with inflammatory arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acr2.1016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857994PMC

The Self-Administered Rheumatoid Arthritis Disease Activity Index (RADAI) is Less Accurate than DAS28-CRP as a Disease Activity Measure in Pregnancy.

ACR Open Rheumatol 2019 Apr 30;1(2):97-103. Epub 2019 Mar 30.

Erasmus University Medical Centre Rotterdam The Netherlands.

Objective: Disease Activity Score 28 (DAS28)-using the C-reactive protein (CRP) level has been validated to determine disease activity in rheumatoid arthritis (RA) patients during pregnancy. A self-administered questionnaire like Rheumatoid Arthritis Disease Activity Index (RADAI) has practical advantages over DAS28-CRP, and in this study, we aimed to validate the RADAI for use during pregnancy.

Methods: Patients were derived from a prospective cohort on RA and pregnancy (Pregnancy-induced Amelioration of Rheumatoid Arthritis study). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acr2.1012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858020PMC

Rheumatoid arthritis and risk of spontaneous abortion: a Danish nationwide cohort study.

Rheumatology (Oxford) 2019 Nov 27. Epub 2019 Nov 27.

Department of Obstetrics.

Objectives: To investigate the influence of RA or preclinical RA on the risk of spontaneous abortion (SA) while taking age and duration of RA into consideration.

Methods: By linkage of data from Danish national registries, we established a nationwide cohort of pregnancies in Denmark from 1 January 1977 to 31 December 2014. We used multiple logistic regression to estimate; odds ratios (OR) for SA in women with RA or preclinical RA, compared with women without, and OR for SA by maternal age in women with RA or preclinical RA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kez565DOI Listing
November 2019

Non-obstetric abdominal surgery during pregnancy and birth outcomes: A Danish registry-based cohort study.

Acta Obstet Gynecol Scand 2020 Apr 26;99(4):469-476. Epub 2019 Dec 26.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Introduction: Surgery during pregnancy may increase the risk of adverse birth outcomes. In this nationwide registry-based cohort study including women aged 15-54 years with singleton birth or miscarriage, we examined the association between non-obstetric abdominal surgery during pregnancy and the birth outcomes small-for-gestational-age (SGA), preterm birth, and miscarriage.

Material And Methods: The study used data on births or miscarriages from the large national Danish registries in 1997-2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aogs.13775DOI Listing

Upadacitinib (Rinvoq) - a new JAK inhibitor for rheumatoid arthritis.

Authors:

Med Lett Drugs Ther 2019 Nov;61(1585):183-185

View Article

Download full-text PDF

Source
November 2019

Maternal rheumatoid arthritis and systemic lupus erythematosus and risk of cryptorchidism and hypospadias in boys: a Danish nationwide study.

Rheumatology (Oxford) 2019 Nov 18. Epub 2019 Nov 18.

Department of Gynaecology and Obstetrics, Horsens Regional Hospital, Horsens, Denmark.

Objectives: RA and SLE are the most prevalent autoimmune rheumatic diseases affecting young women. Both diseases are characterized by systemic inflammation that may affect placental function and fetal development during pregnancy, and both diseases are associated with adverse pregnancy and child outcomes. We investigated the associations between maternal RA or SLE and the two genital malformations, cryptorchidism and hypospadias. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kez538DOI Listing
November 2019

European Network of Pregnancy Registers in Rheumatology (EuNeP)-an overview of procedures and data collection.

Arthritis Res Ther 2019 11 14;21(1):241. Epub 2019 Nov 14.

Department of Rheumatology and Hiller Research Unit, University Clinic Duesseldorf, Duesseldorf, Germany.

Background: The collaborative initiative of the European Network of Pregnancy Registers in Rheumatology (EuNeP) aims to combine data available in nationwide pregnancy registers to increase knowledge on pregnancy outcomes in women with inflammatory rheumatic diseases (IRD) and on drug safety during pregnancy and lactation. The objective of this study was to describe the similarities and differences of the member registers.

Methods: From all registers, information about their structure and design was collected, as well as which parameters regarding demographics, maternal outcomes, treatment, course and outcome of pregnancy, and development of the child were available in the respective datasets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13075-019-2019-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854642PMC
November 2019

Contraception and preconception counseling in women with autoimmune disease.

Best Pract Res Clin Obstet Gynaecol 2020 Apr 8;64:11-23. Epub 2019 Oct 8.

Hospital for Special Surgery - Weill Cornell Medicine, 535 East 70th Street, New York, NY, 10021, USA. Electronic address:

Appropriate contraception and preconception counseling are critical for women of reproductive age with systemic autoimmune diseases (AIDs) because clinical diagnosis, rheumatology medications, and disease activity may impact the safety or efficacy of certain contraceptives as well as the risk of adverse pregnancy outcomes. The presence of antiphospholipid (aPL) antibodies (anticardiolipin, anti-β2 glycoprotein I, and lupus anticoagulant) is the most important determinant of contraception choice, as women with these antibodies should not receive estrogen-containing contraceptives because of the increased risk of thrombosis. Prepregnancy counseling generally includes the assessment of preexisting disease-related organ damage, current disease activity, aPL antibodies, anti-Ro/SS-A and anti-La/SS-B antibodies, and medication safety in pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpobgyn.2019.09.003DOI Listing
April 2020
1 Read

Pregnancy and rheumatoid arthritis.

Best Pract Res Clin Obstet Gynaecol 2020 Apr 9;64:52-58. Epub 2019 Oct 9.

Cleveland Clinic, Department of Rheumatology and Immunology, 9500 Euclid Ave # A50, Cleveland, OH, 44195, USA. Electronic address:

Rheumatoid arthritis commonly affects women of childbearing age. Fertility, family planning, control of disease activity and birth outcomes are all important issues to be discussed at preconception counseling. New data has offered insight on trends of fertility, disease control during pregnancy, and birth outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpobgyn.2019.09.005DOI Listing
April 2020
1 Read

Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases.

Biochim Biophys Acta Rev Cancer 2020 01 19;1873(1):188316. Epub 2019 Oct 19.

Department of Biochemistry & Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:

The regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL, Lethe, MIR31HG, and PACER. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbcan.2019.188316DOI Listing
January 2020

Perinatal use and discontinuation of disease-modifying anti-rheumatic drugs and biologics in women with rheumatoid arthritis: a cohort study.

Rheumatology (Oxford) 2020 Jul;59(7):1514-1521

University of British Columbia, Faculty of Pharmaceutical Sciences, Vancouver, BC, Canada.

Objectives: To characterize the utilization and discontinuation of medications before, during and after pregnancy among women with RA.

Methods: We used population-based administrative data to identify women with RA who had a singleton pregnancy ending in delivery between 1 January 2002 and 31 December 2012. We assessed the utilization of RA medications, namely, conventional synthetic DMARDs, biologics, glucocorticosteroids and NSAIDs, across six windows spanning 24 and 12 months before the start of pregnancy, each trimester of pregnancy and 12 months post-pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kez478DOI Listing
July 2020
1 Read

Glycosylation as an Important Regulator of Antibody Function.

Klin Onkol 2019 ;32(Supplementum 3):46-55

Background: The glycosylation of constant regions of antibodies significantly affects their interaction capabilities with immune cells. It is a modification that, in addition to the bio-logical activity of antibodies, has an impact on their conformation, stability, solubility, secretion, pharmaco-kinetics, and immunogenicity. The location of glycosylations on the molecule is essential for the proper function of the antibody, as is the structure of the individual glycans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14735/amko20193SDOI Listing
March 2020
2 Reads

Birth outcomes in women who have taken adalimumab in pregnancy: A prospective cohort study.

PLoS One 2019 18;14(10):e0223603. Epub 2019 Oct 18.

Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America.

Background: Information is needed on the safety of adalimumab when used in pregnancy for the treatment of certain autoimmune diseases.

Methods And Findings: Between 2004 and 2016, the Organization of Teratology Information Specialists Research Center at the University of California San Diego conducted a prospective controlled observational cohort study in 602 pregnant women who had or had not taken adalimumab. Women in the adalimumab-exposed cohort had received at least one dose of the drug in the first trimester for the treatment of rheumatoid arthritis or Crohn's Disease (N = 257). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223603PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799916PMC
March 2020
7 Reads

Dentists' awareness about the link between oral and systemic health.

J Family Community Med 2019 Sep-Dec;26(3):206-212

Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: Oral health is integral to systemic health. There is a growing body of evidence of an association between periodontal and systemic diseases. The aim of the study was to evaluate the awareness of dentists regarding link between oral and systemic health. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jfcm.JFCM_55_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755758PMC
October 2019
4 Reads