1,666 results match your criteria Rheumatoid Arthritis and Pregnancy


Trial of labor after cesarean section in risk pregnancies: a population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Science, University of Bergen, Norway.

Introduction: In most pregnancies after a cesarean section, a trial of labor is an option. The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate.

Material And Methods: In a cohort study (n=57 109), using data from the Medical Birth Registry of Norway 1989-2014, women with a second delivery after a first pregnancy cesarean section were included. Read More

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http://dx.doi.org/10.1111/aogs.13565DOI Listing
February 2019
1 Read

Effect of biologic disease-modifying anti-rheumatic drugs for patients with rheumatoid arthritis who hope to become mothers.

Clin Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Objectives: We examined the effect of biologic disease-modifying anti-rheumatic drugs on the time to pregnancy in patients with rheumatoid arthritis who hope to become mothers. Additionally, we evaluated adverse pregnancy outcomes and risk factors of these drugs.

Method: We retrospectively investigated 25 pregnancies of 19 patients who were taking disease-modifying anti-rheumatic drugs. Read More

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http://dx.doi.org/10.1007/s10067-019-04450-3DOI Listing
February 2019
1 Read

Discontinuing TNF-inhibitors before gestational week 20 in well-controlled rheumatoid arthritis and juvenile arthritis is not associated with a disease worsening in late pregnancy.

Arthritis Rheumatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Pediatrics and Family Medicine and Public Health, University of California San Diego, San Diego, California, USA.

Objective: To investigate whether the discontinuation of tumor necrosis factor inhibitors (TNFi) during pregnancy is associated with any changes of the disease course in women with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).

Methods: Pregnant women from the U.S. Read More

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http://doi.wiley.com/10.1002/art.40821
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http://dx.doi.org/10.1002/art.40821DOI Listing
January 2019
5 Reads

Decreased chance of a live born child in women with rheumatoid arthritis after assisted reproduction treatment: a nationwide cohort study.

Ann Rheum Dis 2019 Mar 12;78(3):328-334. Epub 2019 Jan 12.

Department D, Centre of Andrology and Fertility Clinic, Odense University Hospital, Odense, Denmark.

Objectives: No studies have examined the efficacy of assisted reproductive technology (ART) treatment in women with rheumatoid arthritis. Therefore, we examined the chance of live birth after ART treatment in women with rheumatoid arthritis compared with women without rheumatoid arthritis.

Methods: Our cohort study is based on nationwide Danish health registries, comprising all women with an embryo transfer during 1 January 1994 through 30 June 2017. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21461
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http://dx.doi.org/10.1136/annrheumdis-2018-214619DOI Listing
March 2019
8 Reads

Prolactin, autoimmunity, and motherhood: when should women avoid breastfeeding?

Clin Rheumatol 2019 Jan 11. Epub 2019 Jan 11.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, 5265601, Tel Hashomer, Israel.

The sexual dimorphic prevalence of autoimmunity represents one of the most alluring observations among the mosaic of autoimmunity. Sex hormones are believed to be a mainstay of this asymmetry. The greater prevalence of autoimmunity among fertile women, disease onset/relapses during pregnancy, and postpartum are some of the points that support this theory. Read More

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http://link.springer.com/10.1007/s10067-018-04415-y
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http://dx.doi.org/10.1007/s10067-018-04415-yDOI Listing
January 2019
9 Reads

Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers.

Genes Immun 2019 Jan 12. Epub 2019 Jan 12.

Genetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA, 94720-3220, USA.

The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during pregnancy. We conducted a case control study using data from the UC San Francisco Mother Child Immunogenetic Study and studies at the Inova Translational Medicine Institute. We imputed human leukocyte antigen (HLA) alleles and minor histocompatibility antigens (mHags). Read More

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http://www.nature.com/articles/s41435-018-0055-7
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http://dx.doi.org/10.1038/s41435-018-0055-7DOI Listing
January 2019
15 Reads
2.913 Impact Factor

Reversible Cerebral Vasoconstriction Syndrome after Administering Etanercept during Puerperium.

J Stroke Cerebrovasc Dis 2019 Jan 7. Epub 2019 Jan 7.

Department of Internal Medicine, Division of Neurology, St. Marianna University of School of Medicine, Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan.

Our objective is to clarify relationship between reversible cerebral vasoconstriction syndrome and administrating etanercept during puerperium. Several lines of evidence have suggested tumor necrosis factor (TNF) as a mediator of vascular dysfunction associated with estrogen deficiency. A 32-year-old woman resumed etanercept (25 mg/week), a TNF inhibitor, which had been discontinued during pregnancy, because of the deterioration of rheumatoid arthritis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10523057183071
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.12.012DOI Listing
January 2019
3 Reads

Posterior Reversible Encephalopathy Syndrome with Stroke in Puerperal Woman with High Titer of Anti-Phospholipid IgM Antibody.

Case Rep Obstet Gynecol 2018 3;2018:7438676. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan.

Posterior reversible encephalopathy syndrome with stroke is very rare in puerperal women. A 36-year-old nulliparous woman with both rheumatoid arthritis and recurrent pregnancy loss, probably due to a high titer of anti-phospholipid IgM antibody, was referred at 10 weeks of gestation. Low-dose aspirin at 100 mg/day and heparin calcium subcutaneous injection at 10,000 units/day were started before pregnancy and stopped at 35 and 40 weeks, respectively. Read More

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https://www.hindawi.com/journals/criog/2018/7438676/
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http://dx.doi.org/10.1155/2018/7438676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304583PMC
December 2018
4 Reads

17-β-estradiol enhances neutrophil extracellular trap formation by interaction with estrogen membrane receptor.

Arch Biochem Biophys 2019 Mar 24;663:64-70. Epub 2018 Dec 24.

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3, Minamitamagaki, Suzuka-city, Mie, 513-8670, Japan. Electronic address:

Cell death-associated neutrophil extracellular trap formation (NETosis) occurs during various autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, as well as during gestation. Although increasing estrogen concentrations associated with pregnancy might induce NETosis via nuclear estrogen receptor (ERα/ERβ), little is known about the mechanisms associated with estrogen-induced NETosis. Here, we investigated the effects of estrogen (17-β-estradiol; E2) on NETosis, focusing on mechanisms associated with estrogen membrane receptor (GPR30) in neutrophil-like HL-60 cells. Read More

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http://dx.doi.org/10.1016/j.abb.2018.12.028DOI Listing
March 2019
2 Reads

Disease activity assessment of rheumatic diseases during pregnancy: a comprehensive review of indices used in clinical studies.

Autoimmun Rev 2019 Feb 18;18(2):164-176. Epub 2018 Dec 18.

Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy.

Pregnancy requires a special management in women with inflammatory rheumatic diseases (RDs), with the aim of controlling maternal disease activity and avoiding fetal complications. Despite the heterogeneous course of RDs during pregnancy, their impact on pregnancy largely relates to the extent of active inflammation at the time of conception. Therefore, accurate evaluation of disease activity is crucial for the best management of pregnant patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15689972183028
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http://dx.doi.org/10.1016/j.autrev.2018.08.008DOI Listing
February 2019
7 Reads

Prevalence and Incidence of Upper Respiratory Tract Infection Events Are Elevated Prior to the Development of Rheumatoid Arthritis in First-Degree Relatives.

Front Immunol 2018 29;9:2771. Epub 2018 Nov 29.

Central Research Laboratory, State Medical Academy, Kazan, Russia.

The aim of this study was to characterize infection events in a longitudinal cohort of first-degree relatives (FDR) of probands with rheumatoid arthritis (RA) and explore their associations with RA development. To this end, newly diagnosed RA patients ( = 283), unaffected related FDR and age-matched healthy women were ascertained from the Caucasian triple women prospective Tatarstan cohort. In this cohort initiated in 1997, 26/283 (9. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02771
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http://dx.doi.org/10.3389/fimmu.2018.02771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281887PMC
November 2018
8 Reads

Activin A in Mammalian Physiology.

Physiol Rev 2019 01;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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http://dx.doi.org/10.1152/physrev.00002.2018DOI Listing
January 2019
6 Reads
27.324 Impact Factor

Genes and transcription factors related to the adverse effects of maternal type I diabetes mellitus on fetal development.

Mol Cell Probes 2019 Feb 14;43:64-71. Epub 2018 Nov 14.

Department of Gynecology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan, 250013, China.

Purpose: Maternal type I diabetes mellitus (T1DM) increases the risk of adverse pregnancy outcomes, but the corresponding mechanism is unclear. This study aims to investigate the mechanism underlying the adverse pregnancy outcomes of maternal T1DM.

Methods: Gene expression microarray (GSE51546) was down-loaded from the Gene Expression Omnibus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908508183017
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http://dx.doi.org/10.1016/j.mcp.2018.11.003DOI Listing
February 2019
13 Reads

Fertility and Ovarian Reserve among Women with Rheumatoid Arthritis.

J Rheumatol 2018 Nov 15. Epub 2018 Nov 15.

From the Division of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA. Pfizer Inc. provided the funding for this project through its ASPIRE award program for investigator-initiated studies. It had no say on the design or conduct of the research, and did not alter the manuscript. M.E. Clowse is a consultant for UCB regarding issues surrounding the use of certolizumab for RA in pregnancy. This work does not involve issues of infertility or AMH. A.M. Eudy, PhD, Postdoctoral Associate, Division of Rheumatology and Immunology, Duke University Medical Center; G. McDaniel, PA-C, Clinical Research Coordinator, Division of Rheumatology and Immunology, Duke University Medical Center; W.W. Hurd, MD, MSc, MPH, Professor and Director, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center; M.E. Clowse, MD, MPH, Associate Professor of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center. Address correspondence to A.M. Eudy, Duke University Medical Center, Division of Rheumatology and Immunology, DUMC 3490, Durham, North Carolina 27710, USA. E-mail: Accepted for publication August 10, 2018.

Objective: We sought to identify causes for infertility in women with and without rheumatoid arthritis (RA).

Methods: Women with RA were matched to healthy controls. Differences in anti-Müllerian hormone (AMH) and anovulation were analyzed. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180176
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http://dx.doi.org/10.3899/jrheum.180176DOI Listing
November 2018
16 Reads

Use of tumor necrosis factor-alpha inhibitors during pregnancy among women who delivered live born infants.

Pharmacoepidemiol Drug Saf 2018 Nov 14. Epub 2018 Nov 14.

Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Purpose: To describe the use of tumor necrosis factor-alpha inhibitors (TNFis) among pregnancies ending in a live birth and with a diagnosis of ankylosing spondylitis (AS), Crohn's disease (CD), juvenile idiopathic arthritis (JIA), psoriasis (PsO), psoriatic arthritis (PsA), rheumatoid arthritis (RA), or ulcerative colitis (UC).

Methods: We identified pregnancies among women aged 15 to 54 years between 01/01/2004 and 09/30/2015 from 16 health plans participating in Sentinel. We inferred indication using ICD-9-CM codes in the 183-day period before conception. Read More

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http://dx.doi.org/10.1002/pds.4695DOI Listing
November 2018
2 Reads

Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.

J Pharm Sci 2019 Jan 3;108(1):661-673. Epub 2018 Nov 3.

Aston Health Research Group, Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK; Aston Pharmacy School, Aston University, Birmingham B4 7ET, UK. Electronic address:

The insidious nature of Zika virus (ZIKV) infections can have a devastating consequence for fetal development. Recent reports have highlighted that chloroquine (CQ) is capable of inhibiting ZIKV endocytosis in brain cells. We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells. Read More

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http://dx.doi.org/10.1016/j.xphs.2018.10.056DOI Listing
January 2019
2 Reads

Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis.

J Rheumatol 2018 Nov 1. Epub 2018 Nov 1.

From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK. This work was undertaken at University College London Hospitals, which received a proportion of funding from the UK Department of Health's National Institute for Health Research Biomedical Research Centres funding scheme. H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London. H. Jethwa and S. Lam contributed equally to this study. Address correspondence to H. Jethwa, Rheumatology Department, Ealing Hospital, Uxbridge Road, Southall UB1 3HW, UK. E-mail: Accepted for publication July 24, 2018.

Objective: We performed a systematic review and metaanalysis to assess rheumatoid arthritis (RA) disease activity during pregnancy using objective disease activity scoring systems.

Methods: A systematic review of PubMed, EMBASE/Medline, Cochrane, and LactMed databases was performed. Our inclusion criteria for analysis were prospective studies, more than 5 patients per study, and data on RA using an objective scoring system conducted by a clinician/health professional. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180226
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http://dx.doi.org/10.3899/jrheum.180226DOI Listing
November 2018
3 Reads

Pregnancy Outcomes of Patients Exposed to Adalimumab in Japan.

Dig Dis 2019 10;37(2):123-130. Epub 2018 Oct 10.

Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan.

Background: This is the first retrospective report of pregnancy outcomes after exposure to adalimumab treatment in Japan.

Methods: Using the AbbVie safety database, we analyzed pregnancy outcome data from patients who received adalimumab treatment from April 16, 2008, to May 15, 2017.

Results: Data were extracted retrospectively for 74 pregnancies in 73 patients. Read More

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https://www.karger.com/Article/FullText/493462
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http://dx.doi.org/10.1159/000493462DOI Listing
February 2019
4 Reads

[Chinese expert-based consensus for methotrexate in rheumatic diseases].

Authors:

Zhonghua Nei Ke Za Zhi 2018 Oct;57(10):719-722

To establish the experts consensus on the use of methotrexate in the treatment of rheumatic diseases. A consensus development panel was established. The panel of consensus was composed of 45 experts in rheumatology from the group of Chinese Association of Rheumatology and Immunology Physicians. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2018.10.005DOI Listing
October 2018
4 Reads

Thrombotic Microangiopathies with Rheumatologic Involvement.

Rheum Dis Clin North Am 2018 11 7;44(4):635-649. Epub 2018 Sep 7.

Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, 2150 Pennsylvania Avenue, Washington, DC 20037, USA. Electronic address:

Thrombotic microangiopathies are heterogeneous disorders characterized by microangiopathic hemolytic anemia with thrombocytopenia and renal injury. There are a variety of causes, including metabolic disorders, infections, medications, complement disorders, pregnancy, malignancy, and autoimmune disorders. This review focuses on renal thrombotic microangiopathy in the setting of rheumatologic diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0889857X183006
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http://dx.doi.org/10.1016/j.rdc.2018.06.010DOI Listing
November 2018
31 Reads

Sonography of active rheumatoid arthritis during pregnancy: a case report and literature review.

Radiol Case Rep 2018 Dec 20;13(6):1233-1237. Epub 2018 Sep 20.

Division of Musculoskeletal Radiology, Department of Radiology, 200 1st Street SW, Rochester, MN 55905.

Disease activity in rheumatoid arthritis usually subsides in pregnancy, however a subset of patients have worsened symptoms with joint pain and swelling. Monitoring and mitigating disease activity in pregnancy is important for preventing deforming structural changes which can affect the ability of the patient to care for themselves and the newborn. Ultrasound is a safe and low-cost imaging modality for detecting active changes from an inflammatory arthritis, which can help guide management. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148827PMC
December 2018
3 Reads

High-throughput Serum -Glycomics: Method Comparison and Application to Study Rheumatoid Arthritis and Pregnancy-associated Changes.

Mol Cell Proteomics 2019 Jan 21;18(1):3-15. Epub 2018 Sep 21.

From the ‡Center for Proteomics and Metabolomics.

-Glycosylation is a fundamentally important protein modification with a major impact on glycoprotein characteristics such as serum half-life and receptor interaction. More than half of the proteins in human serum are glycosylated, and the relative abundances of protein glycoforms often reflect alterations in health and disease. Several analytical methods are currently capable of analyzing the total serum -glycosylation in a high-throughput manner. Read More

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http://dx.doi.org/10.1074/mcp.RA117.000454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317482PMC
January 2019
17 Reads

Role of periodontal therapy in management of common complex systemic diseases and conditions: An update.

Periodontol 2000 2018 10;78(1):212-226

Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.

The goal of this review is to summarize the results of randomized trials reported since 2010 that assessed the effect of periodontal interventions on at least one systemic outcome in human subjects of any age, gender or ethnicity. Oral outcome measures included gingivitis, pocket depth, clinical attachment loss and/or radiographic bone loss and oral hygiene indices. Studies were excluded if the trial was not completed or if treatment was not randomized. Read More

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http://dx.doi.org/10.1111/prd.12226DOI Listing
October 2018
2 Reads

Pregnancy outcomes in women with rheumatoid arthritis: a retrospective population-based cohort study.

J Matern Fetal Neonatal Med 2018 Sep 6:1-7. Epub 2018 Sep 6.

a Department of Obstetrics and Gynecology , Jewish General Hospital, McGill University Montreal , Montreal , Canada.

Purpose: To assess if pregnancies in women with rheumatoid arthritis (RA) are at a higher risk for adverse maternal and neonatal outcomes.

Materials And Methods: A retrospective cohort study was carried out using the Healthcare Cost and Utilization Project - National Inpatient Sample (HCUP-NIS) from the USA. All births that took place from 2004 to 2013 were identified and women were classified as having RA or not on the basis of ICD-9 coding. Read More

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http://dx.doi.org/10.1080/14767058.2018.1498835DOI Listing
September 2018
4 Reads

Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study.

Osteoporos Int 2019 Jan 31;30(1):221-229. Epub 2018 Aug 31.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris-Sud, Department of Rheumatology, Hôpital Bicêtre Université Paris-Sud, INSERM U1184, 78 rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.

We analyzed women and newborn outcome after maternal exposure to BPs. BPs have no teratogenic effect on the 36 analyzed pregnancies compared to unexposed controls matched on women underlying diseases (either systemic disease, either "bone" disease) but some outcome differed: neonatal complications rate in systemic diseases and live birth rate in bone diseases).

Introduction: The effect of bisphosphonates (BPs) during pregnancy remains unclear. Read More

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http://dx.doi.org/10.1007/s00198-018-4672-9DOI Listing
January 2019
2 Reads

Factors associated with preterm delivery among women with rheumatoid arthritis and juvenile idiopathic arthritis.

Arthritis Care Res (Hoboken) 2018 Aug 21. Epub 2018 Aug 21.

Departments of Pediatrics and Family Medicine and Public Health, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093.

Objective: Pregnant women with inflammatory arthritis may be at increased risk for preterm delivery (PTD), yet it is unclear what drives this risk. This prospective cohort study of pregnant women with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), or healthier comparison women analyzed the independent effects of maternal disease activity, medication use, and comorbid pregnancy conditions on PTD risk.

Methods: Women were enrolled before 19 weeks' completed gestation as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project. Read More

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http://dx.doi.org/10.1002/acr.23730DOI Listing
August 2018
9 Reads

Postpartum Depression and Subsequent Autoimmune Diseases in Taiwan.

Int J Environ Res Public Health 2018 08 20;15(8). Epub 2018 Aug 20.

Department of Obstetrics & Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Postpartum depression (PPD) is one of the most common examples of postnatal morbidity, but the subsequent risks of autoimmune diseases in patients with PPD have yet to be fully investigated. This nationwide population-based study utilized data of the National Health Insurance Research Database of Taiwan for the period from 1996 to 2013. In total, 45,451 women with primiparity were identified. Read More

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http://dx.doi.org/10.3390/ijerph15081783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121646PMC
August 2018
10 Reads

Autoimmunity in 2017.

Authors:
Carlo Selmi

Clin Rev Allergy Immunol 2018 Dec;55(3):239-253

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, via A. Manzoni 56, 20089 Rozzano, Milan, Italy.

The number of peer-reviewed articles published during the 2017 solar year and retrieved using the "autoimmunity" key word increased significantly compared to 2016 while maintaining a stable share within the immunology field, following years with alternated fortunes. A detailed arbitrary analysis of the published articles in leading immunology and autoimmunity journals provides a privileged viewpoint on the current trends of research from both basic and clinical studies. Indeed, we are observing that major steps forward are found for rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, among others. Read More

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http://dx.doi.org/10.1007/s12016-018-8699-7DOI Listing
December 2018
20 Reads

Drugs for rheumatoid arthritis.

Authors:

Med Lett Drugs Ther 2018 07;60(1552):123-128

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July 2018
18 Reads

Baricitinib (olumiant) for rheumatoid arthritis.

Authors:

Med Lett Drugs Ther 2018 07;60(1551):120-121

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July 2018
17 Reads

Treatment of chronic inflammatory rheumatism by biotherapy in Gabon : eligibility and follow-up of the first 8 patients in sub-Saharan Africa.

Med Sante Trop 2018 May;28(2):197-200

Université des sciences de la santé, Département de médecine interne, CHU de Libreville, 34000 Libreville, Gabon.

Objective: to clarify the eligibility criteria for biotherapies in patients with chronic inflammatory rheumatism (CIR) in sub-Saharan Africa and to describe the characteristics of the first 8 patients treated with biotherapy in Gabon.

Materials And Methods: Patients who responded inadequately to treatments by cDMARDs (EULAR criteria) had a face-to-face interview to inform them about and obtain their consent to biotherapy for at least 3 months, with details of the cost and side effects of each available biotherapy and a certificate of "necessity of biotherapy". The inclusion and follow-up of patients took place in the outpatient rheumatology consultations at the University Hospital of Libreville (Gabon) between January 2010 and December 2016. Read More

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http://dx.doi.org/10.1684/mst.2018.0781DOI Listing
May 2018
14 Reads

Outcomes of Pregnancies With Maternal/Paternal Exposure in the Tofacitinib Safety Databases for Ulcerative Colitis.

Inflamm Bowel Dis 2018 Nov;24(12):2494-2500

Department of Gastroenterology and Hepatology, Charité Medical Center Virchow Hospital, and Medical School of the Humboldt University of Berlin, Berlin, Germany.

Background: Active inflammatory bowel disease increases the risk of adverse pregnancy outcomes. Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). As a small molecule, tofacitinib is likely to cross the placental barrier; however, information on the effects of tofacitinib on pregnancy outcomes is limited. Read More

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http://dx.doi.org/10.1093/ibd/izy160DOI Listing
November 2018
58 Reads

Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults.

BMC Infect Dis 2018 Jul 4;18(1):302. Epub 2018 Jul 4.

Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d'Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Descartes, Paris, France.

Background: To describe extra-haematological manifestations associated with human parvovirus B19 (HPV-B19) infection.

Methods: We conducted a nationwide multicentre study to retrospectively describe the characteristics and outcome of extra-haematological manifestations in French adults.

Results: Data from 25 patients followed from 2001 to 2016 were analysed. Read More

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http://dx.doi.org/10.1186/s12879-018-3227-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033229PMC
July 2018
27 Reads

[In-label treatment of inflammatory joint diseases].

Authors:
C Kneitz C Fiehn

Z Rheumatol 2018 Sep;77(7):559-568

Praxis für Rheumatologie, Tätigkeitsschwerpunkt Klinische Immunologie und Belegarzteinheit der ViDia-Kliniken Karlsruhe, Medical Center Baden-Baden, Baden-Baden, Deutschland.

The correct use of therapeutic agents in accordance with their approved label is a requirement for a safe therapy and is often linked to the possibility of reimbursement; however, the use of drugs outside the label approval (off-label treatment) is a commonly used practice in rheumatology. This occurs because sufficient clinical trials are often lacking, particularly for rare diseases. This overview gives an insight into the correct use of disease-modifying antirheumatic drugs (DMARDs). Read More

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http://dx.doi.org/10.1007/s00393-018-0498-2DOI Listing
September 2018
2 Reads

Maternal and Fetal Outcomes in a Cohort of Patients Exposed to Tumor Necrosis Factor Inhibitors throughout Pregnancy.

J Rheumatol 2018 Aug 1;45(8):1109-1115. Epub 2018 Jul 1.

From the Department of Allergy and Immunology, McGill University, Montreal, Quebec; TRIO Fertility; Department of Obstetrics and Gynaecology, University of Toronto; Division of Rheumatology, Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Objective: Tumor necrosis factor inhibitors (TNFi) are increasingly used in pregnancy but are frequently withheld in the second or third trimesters. We evaluated the maternal and fetal outcomes of women who continued their TNFi throughout pregnancy compared to women who interrupted TNFi during pregnancy.

Methods: We retrospectively analyzed the outcomes of women seen in clinic with rheumatoid arthritis (RA), psoriatic arthritis, juvenile idiopathic arthritis (JIA), or ankylosing spondylitis, who were exposed to TNFi during pregnancy. Read More

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http://dx.doi.org/10.3899/jrheum.171152DOI Listing
August 2018
8 Reads

The Influence of LPS-Induced Maternal Inflammation on Postnatal Collagen-Induced Arthritis.

Inflammation 2018 Oct;41(5):1842-1851

Division of Clinical Nutrition, Department of Food and Nutrition, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo, 112-8681, Japan.

Maternal health and nutritional status influence offspring health and the diseases that may develop in them. The effects of maternal inflammation on offspring from the perspective of the inflammatory response and immune changes are not fully understood. We hypothesized that maternal inflammation modulates immune and metabolic functions, affecting the pathophysiology of inflammatory diseases in offspring. Read More

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http://dx.doi.org/10.1007/s10753-018-0827-2DOI Listing
October 2018
4 Reads

Patient-Reported Disease Activity and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus and Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2018 Jun 15. Epub 2018 Jun 15.

Rheumatology, Duke University Medical Center, Box 3535, Trent Drive, 27710, Durham, North Carolina, United States.

Objectives: While increased rheumatic disease activity during pregnancy has been associated with adverse pregnancy outcomes, this activity is typically assessed by the physician. Little is known, however, about the association between patient-reported measures of disease activity and pregnancy outcomes.

Methods: Univariate and multivariable regression models were used to assess the relationship between patient and physician-reported measures of disease activity and adverse pregnancy outcomes in 225 patients with lupus or rheumatoid arthritis (RA) enrolled in a prospective registry at a single academic center from 2008-2016. Read More

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http://dx.doi.org/10.1002/acr.23621DOI Listing
June 2018
3 Reads

One year in review 2018: novelties in the treatment of rheumatoid arthritis.

Clin Exp Rheumatol 2018 May-Jun;36(3):347-361. Epub 2018 May 17.

Rheumatology Unit, Department of Clinical Sciences, University of Ferrara, Italy.

The current approach to treatment of rheumatoid arthritis (RA) includes early and aggressive intervention aiming to reach early and persistent low disease activity and remission. New drugs have improved the therapeutic armamentarium of rheumatologists, providing new options for patients. Beyond these innovations, new evidence has improved the safety of therapies and provided tools for the optimisation of long-term management of RA. Read More

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July 2018
6 Reads

Serious Infections in Rheumatoid Arthritis Offspring Exposed to Tumor Necrosis Factor Inhibitors: A Cohort Study.

Arthritis Rheumatol 2018 Oct 30;70(10):1565-1571. Epub 2018 Aug 30.

McGill University Health Center and McGill University, Montreal, Quebec, Canada.

Objective: To evaluate the risk of serious infections in rheumatoid arthritis (RA) offspring exposed to tumor necrosis factor inhibitors (TNFi) in the gestational period compared to unexposed RA offspring, as well as to children from the general population.

Methods: We used US claim data (2011-2015) to identify 2,989 offspring born to women who have RA and a randomly selected group of 14,596 control children, matched ≥4:1 for maternal age, year of delivery, and state of residence. We defined TNFi exposure based on ≥1 filled prescription during pregnancy. Read More

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http://doi.wiley.com/10.1002/art.40536
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http://dx.doi.org/10.1002/art.40536DOI Listing
October 2018
25 Reads

Updated pharmacological management of rheumatoid arthritis for women before, during, and after pregnancy, reflecting recent guidelines.

Ir J Med Sci 2019 Feb 10;188(1):169-172. Epub 2018 May 10.

Rheumatic Musculoskeletal Disease Unit, Our Lady's Hospice an Dublin d Care Services, Harold's Cross, Ireland.

Background: Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease which can cause significant disability, morbidity, mortality, and impaired fertility. It commonly affects women of childbearing age. Managing rheumatoid arthritis (RA) in the perinatal period poses challenges. Read More

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http://link.springer.com/10.1007/s11845-018-1829-7
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http://dx.doi.org/10.1007/s11845-018-1829-7DOI Listing
February 2019
20 Reads

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review.

Clin Drug Investig 2018 Aug;38(8):653-671

Department of Clinical Experimental Oncology, Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.

The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases. Indeed, they have anti-inflammatory, immunomodulating, anti-infective, antithrombotic, and metabolic effects. Read More

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http://link.springer.com/10.1007/s40261-018-0656-y
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http://dx.doi.org/10.1007/s40261-018-0656-yDOI Listing
August 2018
10 Reads

Genome-wide association study and functional analysis of feet and leg conformation traits in Nellore cattle.

J Anim Sci 2018 May;96(5):1617-1627

Departamento de Zootecnia, Universidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Câmpus de Jaboticabal, CEP, Jaboticabal, SP, Brazil.

Feet and leg conformation is evaluated as a subset of conformational structure traits in dairy and beef cattle and is related to the feet and leg quality that can compromise the animals' productive performance and longevity. The aim of this study was to perform a genome-wide association study (GWAS) of two traits related to feet and leg conformation in Nellore cattle to identify chromosomal regions related to the expression of these traits. Phenotypic and pedigree data from 104,725 animals and genotypes from 1,435 animals and 407,730 SNPs were used. Read More

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http://dx.doi.org/10.1093/jas/sky079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140864PMC
May 2018
3 Reads

Tocilizumab concentrations in maternal serum and breast milk during breastfeeding and a safety assessment in infants: a case study.

Rheumatology (Oxford) 2018 08;57(8):1499-1501

Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Neonatal and Reproductive Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1093/rheumatology/key091DOI Listing
August 2018
7 Reads

Risk for adverse pregnancy outcome in axial spondyloarthritis and rheumatoid arthritis: disease activity matters.

Rheumatology (Oxford) 2018 Mar 30. Epub 2018 Mar 30.

Department of Rheumatology, Immunology and Allergology, University Hospital and University of Bern, Bern, Switzerland.

Objective: To analyse pregnancy outcome and delivery mode in patients with RA and axial spondyloarthritis (axSpA) in relation to disease activity and anti-rheumatic drugs.

Methods: Patients with RA and axSpA were compared with age-matched healthy controls (HCs) with respect to pregnancy outcome and delivery mode. Disease activity (DAS28, ASDAS, CRP) and medication use of patients was assessed once at each trimester. Read More

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https://academic.oup.com/rheumatology/article/57/7/1235/4956
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http://dx.doi.org/10.1093/rheumatology/key053DOI Listing
March 2018
15 Reads

ACPA IgG galactosylation associates with disease activity in pregnant patients with rheumatoid arthritis.

Ann Rheum Dis 2018 Aug 3;77(8):1130-1136. Epub 2018 Apr 3.

Department of Rheumatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Objectives: Patients with autoantibody-positive rheumatoid arthritis (RA) are less likely to experience pregnancy-induced improvement of RA disease activity (DAS28-C reactive protein (CRP)) compared with patients with autoantibody-negative RA. Anti-citrullinated protein antibodies (ACPAs) are the most specific autoantibodies for RA. We previously demonstrated that disease improvement is associated with changes in total IgG glycosylation, which regulate antibody effector function. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-212946DOI Listing
August 2018
13 Reads

[A case of limbic encephalitis associated with Sjögren's syndrome mimicking anti N-methyl D-aspartate receptor encephalitis].

Rinsho Shinkeigaku 2018 Apr 31;58(4):229-234. Epub 2018 Mar 31.

Department of Neurology, Osaka City General Hospital.

A 25-year-old woman in her 37 weeks and 5 days pregnant presented with abnormal behavior and memory impairment following a high fever. Her manifestations were diagnosed as limbic encephalitis, and she delivered a baby by Cesarean section. In the operation, bilateral ovarian tumors were found and resected, though they were revealed as non-teratoma afterward. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001109DOI Listing
April 2018
5 Reads

Women with systemic lupus erythematosus get pregnant more easily than women with rheumatoid arthritis.

Rheumatology (Oxford) 2018 06;57(6):1072-1079

Department of Neuromedicine and Movement Science (INB), NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Objectives: To examine possible differences in the ability to get pregnant and time to pregnancy (TTP) in women with SLE and RA, and to study possible influencing factors.

Methods: Data from RevNatus, a Norwegian nationwide prospective observational register including women with inflammatory rheumatic diseases when planning pregnancy or after conception, was used. We compared rate of achieved pregnancy, the pregnancy outcomes live birth or pregnancy loss, and TTP between women with SLE (n = 53) and women with RA (n = 180). Read More

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http://dx.doi.org/10.1093/rheumatology/key049DOI Listing
June 2018
16 Reads

[Odontogenic foci and systemic diseases. A review].

Orv Hetil 2018 Mar;159(11):415-422

Konzerváló és Esztétikai Fogászati Tanszék, Szegedi Tudományegyetem, Fogorvostudományi Kar Szeged.

The aim of the present review is to provide an up-to-date picture of what we know about the connection between odontogenic foci and non-oral diseases. After a brief historical summary, we give an overview on how the odontogenic focus causes disease in distant areas of the body in general, and then we start the discussion of the particular conditions, such as cardiovascular diseases, pneumonia, diabetes mellitus, metabolic syndrome, rheumatoid arthritis and adverse pregnancy outcomes. The review is centered around the two main odontogenic foci: periodontitis and periapical periodontitis, the latter being a widely recognized but rarely discussed oral focus. Read More

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http://dx.doi.org/10.1556/650.2018.31008DOI Listing
March 2018
9 Reads

Patterns of prednisone use during pregnancy in women with rheumatoid arthritis: Daily and cumulative dose.

Pharmacoepidemiol Drug Saf 2018 Apr 28;27(4):430-438. Epub 2018 Feb 28.

Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.

Purpose: To characterize prednisone use in pregnant women with rheumatoid arthritis using individual-level heat-maps and clustering individual trajectories of prednisone dose, and to evaluate the association between prednisone dose trajectory groups and gestational length.

Methods: This study included pregnant women with rheumatoid arthritis who enrolled in the MotherToBaby Autoimmune Diseases in Pregnancy Study (2003-2014) before gestational week 20 and reported prednisone use without another oral glucocorticoid during pregnancy (n = 254). Information on medication use and pregnancy outcomes was collected by telephone interview plus by medical record review. Read More

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http://doi.wiley.com/10.1002/pds.4410
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http://dx.doi.org/10.1002/pds.4410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039094PMC
April 2018
7 Reads