3,428 results match your criteria Rheumatoid Arthritis Spine


Validity and Responsiveness of Combined Inflammation and Combined Joint Damage Scores Based on the OMERACT Rheumatoid Arthritis MRI Scoring System (RAMRIS).

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Rheumatology, Diakonhjemmet Hospital; Institute of Health and Society, University of Oslo, Oslo, Norway; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen; King Christian 10th Hospital for Rheumatic Diseases; University of Southern Denmark, Institute of Regional Health Research, Graasten; Institute of Clinical Medicine, Aarhus University Hospital, Århus; Odense University Hospital; Institute of Clinical Research, University of Southern Denmark, Odense; Zealand University Hospital, Køge, Denmark; University of New South Wales, Sydney, Australia; Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. U. Sundin, MD, Research Fellow, Department of Rheumatology, Diakonhjemmet Hospital, and Institute of Health and Society, University of Oslo; M. Østergaard, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and the Department of Clinical Medicine, University of Copenhagen; D. Glinatsi, MD, PhD, Postdoctoral Researcher, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; A.B. Aga, MD, PhD, Senior Consultant and Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital Oslo; K. Hørslev-Petersen, MD, DMSc, Professor, Senior Consultant, King Christian 10th Hospital for Rheumatic Diseases, and the Institute of Regional Health Research, University of Southern Denmark; M.L. Hetland, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and the Department of Clinical Medicine, University of Copenhagen; K. Stengaard-Pedersen, MD, DMSc, Professor Emeritus, Institute of Clinical Medicine, Aarhus University Hospital; P. Junker, MD, DMSc, Professor, Department of Rheumatology, Odense University Hospital and Institute of Clinical Research, University of Southern Denmark; B.J. Ejbjerg, MD, PhD, Chief Consultant, Zealand University Hospital; P. Bird, BMed (Hons), FRACP, PhD, Grad Dip MRI, Associate Professor, University of New South Wales; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S. Lillegraven, MD, MPH, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital; E.A. Haavardsholm, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, and Institute of Health and Society, University of Oslo. Address correspondence to Dr. U. Sundin, Diakonhjemmet Sykehus, Diakonveien 12, 0370 Oslo, Norway. E-mail: Accepted for publication December 6, 2018.

Objective: The RAMRIS [Outcome Measures in Rheumatology rheumatoid arthritis (RA) magnetic resonance imaging (MRI) Scoring system] is used in clinical RA trials. We have investigated methods to combine the RAMRIS features into valid and responsive scores for inflammation and joint damage.

Methods: We used data from 3 large randomized early RA trials to assess 5 methods to develop a combined score for inflammation based on RAMRIS bone marrow edema, synovitis, and tenosynovitis scores, and a combined joint damage score based on erosions and joint space narrowing. Read More

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http://dx.doi.org/10.3899/jrheum.181064DOI Listing
February 2019

Conventional synthetic disease-modifying antirheumatic drugs and bone mineral density in rheumatoid arthritis patients with osteoporosis: possible beneficial effect of leflunomide.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology, Department of Medicine, University of Ulsan, College of Medicine, Asan Medical Centre, Seoul, Korea.

Objectives: To investigate the effect of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) on bone mineral density (BMD) in rheumatoid arthritis (RA) patients with osteoporosis.

Methods: Patients with RA who were newly diagnosed with osteoporosis (T-score ≤ -2.5) between 2010 and 2017 were included. Read More

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February 2019

Correction: Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Pharmacogenomics J 2019 Feb 14. Epub 2019 Feb 14.

Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain.

The original version of this Article contained an error in the spelling of the author Ana Rodríguez-Ramos, which was incorrectly given as Ana Rodríguez Ramos. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41397-019-0084-2DOI Listing
February 2019

Bortezomib Improved the Joint Manifestations of Rheumatoid Arthritis in Three Patients.

Joint Bone Spine 2019 Feb 5. Epub 2019 Feb 5.

Service de rhumatologie, centre hospitalier Jean Rougié Cahors 46000, France.

The proteasome inhibitor bortezomib has been proven effective in the treatment of multiple myeloma. We report on 3 patients with rheumatoid arthritis and multiple myeloma in whom bortezomib therapy was associated with improvements in the joint manifestations. The contribution to this effect of the concomitant glucocorticoid therapy is discussed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X193001
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http://dx.doi.org/10.1016/j.jbspin.2019.01.019DOI Listing
February 2019
2 Reads

The efficacy of the traditional Chinese medicine Jia Wei Niu Bang Zi granule combined with methotrexate in treating active rheumatoid arthritis: A multicenter, randomized, double-blinded controlled clinical trial.

Medicine (Baltimore) 2019 Feb;98(6):e14424

Longhua Hospital, Shanghai University of Traditional Chinese Medicine.

Background: Rheumatoid arthritis (RA) is a chronic systemic and autoimmune inflammatory disease ending with the destruction of joints. Current therapies can relieve RA symptoms, but some also bring severe adverse events. Therefore, an effective and safe therapeutic strategy remains to be created to benefit patients with RA by large. Read More

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http://dx.doi.org/10.1097/MD.0000000000014424DOI Listing
February 2019
2 Reads
5.723 Impact Factor

Increased antibody levels to stage-specific Epstein-Barr virus antigens in systemic autoimmune diseases reveal a common pathology.

Scand J Clin Lab Invest 2019 Feb 6:1-10. Epub 2019 Feb 6.

h Department of Autoimmunology and Biomarkers , Statens Serum Institut , Copenhagen , Denmark.

The immune responses to antigens from different stages of the Epstein-Barr virus (EBV) life cycle were investigated in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS), and systemic sclerosis (SSc) to gain knowledge of EBV's involvement in the etiology of systemic autoimmune diseases (SADs) and for an overview of the humoral immune responses against EBV. Investigations were performed by the use of ELISA. IgM, IgA, and IgG antibody binding to 11 EBV antigens: EBNA1, EBNA2, BALF5, EAD, BALF2, EA/R, VCA p18, VCA p23, gB, gp350, and gp42 were examined in serum pools from SAD patients and healthy controls (HCs). Read More

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http://dx.doi.org/10.1080/00365513.2018.1550807DOI Listing
February 2019
1 Read

Effect of Magnetic Resonance Imaging vs Conventional Treat-to-Target Strategies on Disease Activity Remission and Radiographic Progression in Rheumatoid Arthritis: The IMAGINE-RA Randomized Clinical Trial.

JAMA 2019 02;321(5):461-472

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.

Importance: Whether using magnetic resonance imaging (MRI) to guide treatment in patients with rheumatoid arthritis (RA) improves disease activity and slows joint damage progression is unknown.

Objective: To determine whether an MRI-guided treat-to-target strategy vs a conventional clinical treat-to-target strategy improves outcomes in patients with RA in clinical remission.

Design, Setting, And Participants: Two-year, randomized, multicenter trial conducted at 9 hospitals in Denmark. Read More

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http://dx.doi.org/10.1001/jama.2018.21362DOI Listing
February 2019
1 Read

Anti-citrullinated protein antibodies are associated with osteopenia but not with pain at diagnosis of rheumatoid arthritis: data from the BARFOT cohort.

Arthritis Res Ther 2019 Feb 4;21(1):45. Epub 2019 Feb 4.

Department of Clinical Science, Section of Rheumatology, Faculty of Medicine Lund University, Lund, Sweden.

Background: Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addressed if anti-cyclic citrullinated (anti-CCP) antibodies were associated with osteopenia or pain in patients with RA, at the time for diagnosis.

Methods: Baseline data from the BARFOT (Better Anti-Rheumatic PharmacOTherapy) cohort, which consists of patients with RA with a disease duration of 1 year or less, were analyzed. Read More

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http://dx.doi.org/10.1186/s13075-019-1833-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360733PMC
February 2019
1 Read

Corneal and Scleral Involvement in Inflammatory Joint Disease: Rheumatologists and Ophthalmologists Exchanging Views.

Joint Bone Spine 2019 Jan 31. Epub 2019 Jan 31.

Inserm UMR 1125, 1, rue de Chablis, 93017 Bobigny, France; Service de rhumatologie, Assistance publique-Hôpitaux de Paris (AP-HP), groupe hospitalier Avicenne - Jean-Verdier-René-Muret, 125, rue de Stalingrad, 93017 Bobigny, France.

Corneal and scleral disorders related to inflammatory rheumatic diseases vary both in frequency and in severity. Sicca syndrome and its complications are the most common ocular manifestations and, together with episcleritis, can usually be managed by topical treatments. In contrast, the various forms of scleritis and peripheral ulcerative keratitis generally require systemic glucocorticoid therapy and the initiation or intensification of immunosuppressive treatment. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.014DOI Listing
January 2019

Ultrasonographic criteria for the diagnosis of erosive rheumatoid arthritis using osteoarthritic patients as controls compared to validated radiographic criteria.

Joint Bone Spine 2019 Jan 31. Epub 2019 Jan 31.

Department of Rheumatology, University Hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France; INSERM, CIC-EC CIE6, University Hospital of Nancy, Epidemiology and Clinical Evaluation, 54500 Vandoeuvre-lès-Nancy, France.

Objectives: The aims of this study were to compare characteristics of radiography (RX) and ultrasound (US) erosive lesions in rheumatoid arthritis (RA) and osteoarthritis (OA) patients (prevalence, topography and severity), to determine thresholds for the diagnosis of erosive RA based on US and to evaluate the performance of US and RX to establish a diagnosis of erosive RA differentiated from hand OA.

Methods: Patients fulfilling ACR 1987 and/or ACR/EULAR 2010 criteria for RA or ACR hand OA criteria were prospectively included. A modified Sharp erosion score was assessed by two blinded readers and one adjudicator for discordant cases (number of eroded joints ≤ three). Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.011DOI Listing
January 2019
1 Read

Comorbidities in inflammatory joint and spine diseases in XXI century.

Ter Arkh 2018 Dec;90(12):90-95

V.I. Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation, Saratov, Russia.

Aim: The evaluation the occurrence of comorbidities in patients with inflammatory diseases of the spine and joints and the assessment of the general changes in comorbidities at the beginning of the XXI century compared to previous period.

Materials And Methods: Comorbidity was analyzed in 245 patients with spondyloarthritis who participated in the scientific program PROGRESS. Validated comorbidity assessment indices were used in the study. Read More

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http://ter-arkhiv.ru/en/archive/2018/vol-90-12-2018/comorbid
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http://dx.doi.org/10.26442/00403660.2018.12.000015DOI Listing
December 2018
3 Reads

Pathogenic Effects of Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis - Role for Glycosylation.

Joint Bone Spine 2019 Jan 24. Epub 2019 Jan 24.

Service d'Immunologie, Pierre-Bénite, Hospices Civils de Lyon, CHU Lyon-sud, 165, chemin du Grand Revoyet, 69310 Pierre-Bénite, France; Unité d'Immunogénomique & Inflammation, EA4130, Hôpital Edouard Herriot, 5 place d'Arsonval, 69003 Lyon, France; Faculté de médecine Lyon-Est, Université de Lyon, 8 avenue Rockefeller, 69008 Lyon, France. Electronic address:

The identification in 1998 of the main antigenic substrate recognized by autoantibodies was a dramatic turning point in our understanding of rheumatoid arthritis (RA) biology. Now, two decades later, antibodies to citrullinated peptides are viewed no longer as mere biomarkers for RA, but also as major pathophysiological factors involved in the development of bone loss and joint pain. These pathogenic effects are ascribable to abnormal autoantibody glycosylation via a pathway involving the Th17 T cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X193000
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http://dx.doi.org/10.1016/j.jbspin.2019.01.005DOI Listing
January 2019
6 Reads
2.901 Impact Factor

Odontoid cervical gout causing atlantoaxial instability: case report.

J Neurosurg Spine 2019 Jan 25:1-4. Epub 2019 Jan 25.

Departments of1Neurosurgery and.

The authors present a case report of a patient discovered to have a rotatory subluxation of the C1-2 joint and a large retroodontoid pannus with an enhancing lesion in the odontoid process eventually proving to be caused by gout. This patient represented a diagnostic conundrum as she had known prior diagnoses of not only gout but also sarcoidosis and possible rheumatoid arthritis, and was in the demographic range where concern for an oncological process cannot fully be ruled out. Because she presented with signs and symptoms of atlantoaxial instability, she required posterior stabilization to reduce the rotatory subluxation and to stabilize the C1-2 instability. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18122DOI Listing
January 2019
6 Reads

Hypertrophic cervical spine pachymeningitis due to sarcoidosis: a case report.

Hosp Pract (1995) 2019 Feb 6:1-5. Epub 2019 Feb 6.

d Pathology , Lehigh Valley Health Network , Allentown , PA , USA.

Hypertrophic pachymeningitis (HP) is a chronic, progressive diffuse inflammatory condition that leads to thickening of the dura mater and can be idiopathic or associated with sarcoidosis among other disorders. In this case report, we present a rare case of cervical spine HP in a 29-year-old woman in the post-partum period, who had a history of pituitary adenoma and juvenile rheumatoid arthritis. Magnetic resonance imaging (MRI) of the spine revealed a soft tissue mass and moderate cord compression. Read More

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https://www.tandfonline.com/doi/full/10.1080/21548331.2019.1
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http://dx.doi.org/10.1080/21548331.2019.1575645DOI Listing
February 2019
8 Reads

Reduction in Upper Limb Joint Surgery among Rheumatoid Arthritis Patients: An Interrupted Time Series Analysis using Danish Health Care Registers.

Arthritis Care Res (Hoboken) 2019 Jan 25. Epub 2019 Jan 25.

Center for Rheumatology and Spine Diseases, Rigshospitalet - Gentofte, Copenhagen, Denmark.

Objectives: Joint replacement surgery is a proxy of severe joint damage in rheumatoid arthritis (RA). The aim of this study was to assess the impact of the introduction of biological DMARDs (bDMARDs) on the incidence rate (IR) of upper limb joint replacements among newly diagnosed RA patients.

Methods: Using the Danish National Patient Register, incident RA patients from 1996-2012 were identified. Read More

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http://dx.doi.org/10.1002/acr.23835DOI Listing
January 2019
2 Reads

Outcomes of Minimally Invasive Oblique Lumbar Interbody Fusion in Patients with Lumbar Degenerative Disease with Rheumatoid Arthritis.

J Neurol Surg A Cent Eur Neurosurg 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurosurgery, Seoul St. Mary's Hospital, Seoul, The Republic of Korea.

Purpose Of Study:  Standard treatment protocols for lumbar degenerative lesions in the setting of rheumatoid arthritis (RA) are lacking. The purpose of this study was to evaluate the clinical and radiologic outcomes of minimally invasive oblique lumbar interbody fusion (MI-OLIF) in RA patients having degenerative lumbar spine lesions.

Methods:  This was a retrospective hospital-based case series (evidence level 4). Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676301
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http://dx.doi.org/10.1055/s-0038-1676301DOI Listing
January 2019
3 Reads

Translocation of dead or alive bacteria from mucosa to joints and epiphyseal bone-marrow: facts and hypotheses.

Joint Bone Spine 2019 Jan 21. Epub 2019 Jan 21.

Rheumatology Unit, CHRU de Besançon, and EA4266 (Pathogens and inflammation, EPILAB) Université Bourgogne Franche-Comté. Boulevard Fleming, 25030 Besançon, France.

The recent demonstration that DNA from several mucosal bacteria, including Prevotella spp, could be found in numerous tissues (mesenteric lymph nodes, spleen, serum, liver, lung, eye and ankle joints), either in HLA-B27 rats with or without arthritis, or control rats without HLA-B27, could be a revolution in our understanding of spondyloarthritis and close disorders, including rheumatoid arthritis. Indeed, similar translocations of dead or alive bacteria or fungi from mucosa to joints, could contribute to the onset and flares of inflammatory rheumatisms. This state of the art article addresses six questions revived by this finding: 1-How does this bacterial DNA or living bacteria traffic from mucosa to joints? 2-Can some mucosal bacteria remain alive in those tissues, including joints? 3-Could bacteria from the gut microbiota ('self-bacteria') protect the host cells from invasion by more pathogenic bacteria (like dog-shepherds protect from wolves)? 4-Does the composition of the joint or bone marrow microbiota depends on local metabolism, which might differ from gut metabolism? 5-Could bacterial antigens from mucosal microbiota be sufficient to trigger trained immunity of presenting cells in joints, or does such phenomenon (with lasting epigenetic changes of presenting cells) require intra-cellular infection of presenting cells or their ancestors? 6-In which subsets of cells could living bacteria preferentially persist for a long period in the joint area? Transient or dormant infections within bone-marrow mesenchymal stem cells leading to trained immunity of some of their daughter cells in joints or enthesis, lasting after clearance or the invader, is an attractive hypothesis to test. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.004DOI Listing
January 2019
5 Reads

Systemic calprotectin and chronic inflammatory rheumatic diseases.

Joint Bone Spine 2019 Jan 17. Epub 2019 Jan 17.

GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France; Sinnovial SAS, Avenue de Kimberley, 38130 Échirolles, France.

Calprotectin is a calcium binding protein produced by neutrophils and monocytes locally at the site of inflammation in order to trigger the innate immunity receptors. This unique characteristic makes it a good proxy for evaluation of local inflammation in chronic inflammatory rheumatic diseases. Complete data suggest, in inflammatory rheumatic diseases, a relevant role of calprotectin in the inflammatory process. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183034
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http://dx.doi.org/10.1016/j.jbspin.2019.01.003DOI Listing
January 2019
10 Reads

Impact of TNF inhibitor therapy on joint replacement rates in rheumatoid arthritis: a matched cohort analysis of BSRBR-RA UK registry data.

Rheumatology (Oxford) 2019 Jan 10. Epub 2019 Jan 10.

Pharmaco- and Device-Epidemiology Group, Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford.

Objectives: Previous ecological data suggest a decline in the need for joint replacements in RA patients following the introduction of TNF inhibitor (TNFi) therapy, although patient-level data are lacking. Our primary aim was to estimate the association between TNFi use and subsequent incidence of total hip replacement (THR) and total knee replacement.

Methods: A propensity score matched cohort was analysed using the British Society for Rheumatology Biologics Registry (2001-2016) for RA data. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key424DOI Listing
January 2019
5 Reads

[A strategy of combining posterior occipitocervical angle with occipital-C angle for adjustment of occipitocervical fixation angle in posterior instrumented occipitocervical fusion].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Jan;33(1):35-40

Operating Room, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To assess the application and the effectiveness of a strategy of combining posterior occipitocervical angle (POCA) with occipital-C (O-C ) angle for adjustment of occipitocervical fixation angle in posterior instrumented occipitocervical fusion.

Methods: The clinical data of 22 patients undergoing posterior instrumented occipitocervical fusions between March 2013 and January 2016 were retrospectively analysed, and all patients were performed by using a strategy combining with POCA and O-C angle for adjustment of occipitocervical fixation angle. All patients suffered from occipitocervical instability, including 7 males and 15 females with an average age of 44. Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201807115
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http://dx.doi.org/10.7507/1002-1892.201807115DOI Listing
January 2019
5 Reads

Prevalent vertebral fracture on bone density lateral spine (VFA) images in routine clinical practice predict incident fractures.

Bone 2019 Jan 8;121:72-79. Epub 2019 Jan 8.

University of Manitoba, Winnipeg, Canada.

Purpose: The predictive validity of vertebral fracture assessment (VFA) on bone density lateral spine images to identify prevalent vertebral fractures in routine clinical practice has not been established. Our objective was to estimate the associations of prevalent vertebral fracture identified on VFA images in routine practice with incident hip, all non-vertebral, major osteoporotic, and clinical vertebral fractures, using the Manitoba Bone Density database.

Methods: From 2010 onward, 9972 men and women (mean age [SD] 76 [6. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193000
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http://dx.doi.org/10.1016/j.bone.2019.01.009DOI Listing
January 2019
5 Reads

Risk of serious infections in patients with rheumatoid arthritis treated in routine care with abatacept, rituximab and tocilizumab in Denmark and Sweden.

Ann Rheum Dis 2019 Mar 5;78(3):320-327. Epub 2019 Jan 5.

DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen, Denmark.

Objective: To estimate (1) crude and age-and gender-adjusted incidence rates (IRs) of serious infections (SI) and (2) relative risks (RR) of SI in patients with rheumatoid arthritis (RA) initiating treatment with abatacept, rituximab or tocilizumab in routine care.

Methods: This is an observational cohort study conducted in parallel in Denmark and Sweden including patients with RA in Denmark (DANBIO) and Sweden (Anti-Rheumatic Treatment in Sweden Register/Swedish Rheumatology Quality Register) who started abatacept/rituximab/tocilizumab in 2010-2015. Patients could contribute to more than one treatment course. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21432
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http://dx.doi.org/10.1136/annrheumdis-2018-214326DOI Listing
March 2019
24 Reads

The Craniovertebral Junction in Rheumatoid Arthritis: State of the Art.

Acta Neurochir Suppl 2019 ;125:79-86

Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, Neurosurgical Clinic, University of Palermo, Palermo, Italy.

Rheumatoid arthritis (RA) is a chronic inflammatory disorder, characterized by polyarticular inflammation causing progressive joint damage and disability. The mechanisms underlying its pathogenesis involve activation of innate and adaptive immunity, microvascular endothelial cell activation, and inflammatory infiltration of lymphocytes and monocytes into the synovium. Spinal involvement in RA is not typical; when it occurs, the main radiological features are (1) atlantoaxial subluxation (AAS), which is the most typical form of cervical spine involvement; (2) cranial settling-also known as basilar impression, atlantoaxial impaction or superior migration of the odontoid-which is the most severe form of associated spinal instability; and (3) subaxial subluxation. Read More

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http://dx.doi.org/10.1007/978-3-319-62515-7_12DOI Listing
January 2019
3 Reads

Survivorship and long-term outcome of a consecutive series of 200 Scandinavian Total Ankle Replacement (STAR) implants.

Bone Joint J 2019 Jan;101-B(1):47-54

Wrightington Hospital, Wigan, UK.

Aims: We report the long-term clinical and radiological outcomes of a consecutive series of 200 total ankle arthroplasties (TAAs, 184 patients) at a single centre using the Scandinavian Total Ankle Replacement (STAR) implants.

Patients And Methods: Between November 1993 and February 2000, 200 consecutive STAR prostheses were implanted in 184 patients by a single surgeon. Demographic and clinical data were collected prospectively and the last available status was recorded for further survival analysis. Read More

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http://dx.doi.org/10.1302/0301-620X.101B1.BJJ-2018-0801.R1DOI Listing
January 2019
3 Reads

Comparative study for haplotype block partitioning methods - Evidence from chromosome 6 of the North American Rheumatoid Arthritis Consortium (NARAC) dataset.

PLoS One 2018 31;13(12):e0209603. Epub 2018 Dec 31.

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Haplotype-based methods compete with "one-SNP-at-a-time" approaches on being preferred for association studies. Chromosome 6 contains most of the known genetic biomarkers for rheumatoid arthritis (RA) disease. Therefore, chromosome 6 serves as a benchmark for the haplotype methods testing. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209603PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312333PMC
December 2018
1 Read
3.234 Impact Factor

Adjustment of the multi-biomarker disease activity score to account for age, sex and adiposity in patients with rheumatoid arthritis.

Rheumatology (Oxford) 2018 Dec 24. Epub 2018 Dec 24.

Myriad Genetics Inc., Salt Lake City, UT, USA.

Objective: To develop and evaluate an adjusted score for the multi-biomarker disease activity (MBDA) test to account for the effects of age, sex and adiposity in patients with RA.

Methods: Two models were developed to adjust MBDA score for age, sex and adiposity, using either serum leptin concentration or BMI as proxies for adiposity. Two cohorts were studied. Read More

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http://dx.doi.org/10.1093/rheumatology/key367DOI Listing
December 2018
7 Reads

Pristane-induced arthritis in dark Agouti rat is a relevant model for mimicking vascular dysfunction and lipid paradox in rheumatoid arthritis.

Joint Bone Spine 2018 Dec 19. Epub 2018 Dec 19.

PEPITE EA4267, FHU INCREASE, Université Bourgogne Franche-Comté, 25000 Besançon, France.

Objectives: To understand the pathophysiology of cardiovascular (CV) dysfunction in rheumatoid arthritis (RA) is crucial, but limited by the paucity of animal models able to mimic CV impairments. We wanted to determine if the rat model of Pristane-Induced Arthritis (PIA) reproduced cardiometabolic impairments of RA.

Methods: Dark Agouti rats received an injection of pristane or saline (controls) at day 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183026
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http://dx.doi.org/10.1016/j.jbspin.2018.12.001DOI Listing
December 2018
8 Reads

Assessment of Peptidylarginine Deiminase Activity by ELISA Using Human Fibrinogen as Substrate.

Methods Mol Biol 2019 ;1901:239-242

Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

An enzyme-linked immunosorbent assay (ELISA) for measurement of the activity of peptidylarginine deiminases (PADs), the enzymes responsible for citrullination, is described. It uses fibrinogen as substrate for the enzyme and a commercial antibody specific for the citrullinated form of fibrinogen. Read More

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http://dx.doi.org/10.1007/978-1-4939-8949-2_20DOI Listing
January 2019

New concepts to reduce glucocorticoid toxicity.

Joint Bone Spine 2018 Dec 5. Epub 2018 Dec 5.

Schlosspark-Klinik Charité University Medicine Berlin, Heubnerweg, 2, 14059 Berlin, Germany.

70 years after their first use, low-dose glucocorticoids are a common part of pharmacological rheumatoid arthritis treatment. This is due to their well-proven capacities in symptom severity and disease activity reduction, in particular when combined with a disease-modifying anti-rheumatic drug, such as methotrexate. Nevertheless, glucocorticoid administration, in long-term especially, is also seen critically because of its potential adverse conditions. Read More

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http://dx.doi.org/10.1016/j.jbspin.2018.11.006DOI Listing
December 2018
2 Reads

Taxifolin Inhibits Receptor Activator of NF-κB Ligand-Induced Osteoclastogenesis of Human Bone Marrow-Derived Macrophages in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo.

Pharmacology 2019 6;103(1-2):101-109. Epub 2018 Dec 6.

Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha,

It has been reported that taxifolin inhibit osteoclastogenesis in RAW264.7 cells. In our research, the inhibition effects of taxifolin on the osteoclastogenesis of human bone marrow-derived macrophages (BMMs) induced by receptor activator of NF-κB ligand (RANKL) as well as the protection effects in lipopolysaccharide-induced bone lysis mouse model have been demonstrated. Read More

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https://www.karger.com/Article/FullText/495254
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http://dx.doi.org/10.1159/000495254DOI Listing
December 2018
12 Reads

A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis.

Clin Rheumatol 2018 Dec 1. Epub 2018 Dec 1.

Laboratory of Immunology, Research Unit UR 807, Faculty of Medicine of Sousse, Ibn Al Jazzar street, 4000, Sousse, Tunisia.

Objectives: This study was aimed to investigate the association of the single nucleotide polymorphism of tumor necrosis factor receptor associated factor 6 (TRAF6), rs540386, with low bone mineral density (BMD) among patients with rheumatoid arthritis (RA).

Methods: TRAF6 rs540386 genotyping was performed by mutagenically separated PCR in a cohort of 188 (23 men, 165 women, median age, 56.2 years) adult RA patients and 224 age and gender-matched controls. Read More

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http://dx.doi.org/10.1007/s10067-018-4362-1DOI Listing
December 2018
4 Reads

Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.

J Neuroinflammation 2018 Dec 3;15(1):335. Epub 2018 Dec 3.

János Szentágothai Research Centre, Molecular Pharmacology Research Team and Centre for Neuroscience, University of Pécs, Pécs, Hungary.

Objective: The regulatory role of capsaicin-sensitive peptidergic sensory nerves has been shown in acute inflammation, but little is known about their involvement in T/B-cell driven autoimmune arthritis. This study integratively characterized the function of these nerve endings in the proteoglycan-induced chronic arthritis (PGIA), a translational model of rheumatoid arthritis.

Methods: Peptidergic afferents were defunctionalized by resiniferatoxin (RTX) pretreatment in BALB/c mice, PGIA was induced by repeated antigen challenges. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1364-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276168PMC
December 2018
8 Reads

FRAX 10-yr Fracture Risk in Rheumatoid Arthritis-Assessments With and Without Bone Mineral Density May Lead to Very Different Results in the Individual Patient.

J Clin Densitom 2019 Jan - Mar;22(1):31-38. Epub 2018 Oct 31.

Osteoporosis Clinic and Center for Rheumatology and Spine Diseases and the DANBIO Registry, Copenhagen University Hospital Gentofte and Rigshospitalet, Denmark.

Objectives: FRAX is a computer-based algorithm developed by the World Health Organisation for estimation of the 10-yr risk of a hip or major osteoporotic fracture. Inclusion of femoral neck bone mineral density (BMD) in the estimation is optional. The study aimed to investigate the intra-individual agreement between FRAX fracture risk calculated with and without BMD in patients with rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1016/j.jocd.2018.10.007DOI Listing
October 2018
4 Reads

Long-term, health-enhancing physical activity is associated with reduction of pain but not pain sensitivity or improved exercise-induced hypoalgesia in persons with rheumatoid arthritis.

Arthritis Res Ther 2018 Nov 26;20(1):262. Epub 2018 Nov 26.

Department of Clinical Neuroscience, Karolinska Institutet, Nobels väg 9, SE-171 77, Stockholm, Sweden.

Background: We aimed to evaluate the 1-year and 2-year outcome of a health-enhancing physical activity (HEPA) support program on global pain, pressure pain sensitivity, and exercise-induced segmental and plurisegmental hypoalgesia (EIH) in persons with rheumatoid arthritis (RA).

Methods: Thirty participants (27 women and 3 men) were recruited from a larger intervention cohort that engaged in strength training and moderate-intensity aerobic activity. Assessments were performed before the HEPA intervention and at 1-year and 2-year follow-ups. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1758-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260682PMC
November 2018
6 Reads

Risk factors for surgical site infection following lumbar spinal surgery: a meta-analysis.

Authors:
Lin Zhang Er-Nan Li

Ther Clin Risk Manag 2018 31;14:2161-2169. Epub 2018 Oct 31.

Department of Spine Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China,

Objective: To identify risk factors for surgical site infection (SSI) in patients who had undergone lumbar spinal surgery.

Methods: Studies published in PubMed, Web of Science, and Embase were systematically reviewed to determine risk factors for SSI following lumbar spinal surgery. Results are expressed as risk ratios (RRs) with 95% CIs and weighted mean difference (WMD) with 95% CI. Read More

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http://dx.doi.org/10.2147/TCRM.S181477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217168PMC
October 2018
18 Reads

Imaging in rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and osteoarthritis: An international viewpoint on the current knowledge and future research priorities.

Eur J Rheumatol 2018 Nov 16:1-10. Epub 2018 Nov 16.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

Imaging is increasingly used in the routine management of rheumatic diseases as well as in the clinical trials of these disorders. This viewpoint, authored by a group of international imaging experts following two meetings dedicated to imaging in rheumatology, reports a consensus about the current knowledge and addresses where further research should be focused based on the views of the international imaging experts and discussion of the evidence with attending imaging practitioners. The goal was to maximize the potential of imaging to improve the clinical management of four rheumatic diseases. Read More

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http://dx.doi.org/10.5152/eurjrheum.2018.18121DOI Listing
November 2018
3 Reads

Comparing patient-reported outcomes entered at home versus at hospital, and testing touch screens for initial recruitment to scientific trials in arthritis patients.

Scand J Rheumatol 2018 Nov 16:1-7. Epub 2018 Nov 16.

a The Danish Rheumatologic Database (DANBIO) and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet , Glostrup , Denmark.

Objectives: Touch screens for entering patient-reported outcomes (PROs) are available at all Danish departments of rheumatology reporting to the nationwide DANBIO registry. This project comprises two substudies in patients with rheumatoid arthritis (RA) or axial spondyloarthritis (AxSpA), aiming to (A) investigate the feasibility of first line patient recruitment for research via touch screens, and (B) compare PROs collected at hospital versus at home, including patient preferences.

Method: Substudy A: using a touch screen, patients answered whether we could contact them about a clinical research project (yes/no). Read More

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http://dx.doi.org/10.1080/03009742.2018.1522666DOI Listing
November 2018
12 Reads

Sclerostin rather than Dickkopf-1 is associated with mSASSS but not with disease activity score in patients with ankylosing spondylitis.

Clin Rheumatol 2018 Nov 15. Epub 2018 Nov 15.

Department of Rheumatology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, No.88, Jiefang Road, Hangzhou, 310009, China.

Objective: To determine the serum levels of Dickkopf-1 (DKK-1) and sclerostin, as well as their correlations with the structural damage assessed by modified stoke ankylosing spondylitis spine score (mSASSS) and the disease activity evaluated by ankylosing spondylitis disease activity score (ASDAS) in patients with ankylosing spondylitis (AS).

Methods: Eighty-eight AS patients, 26 rheumatoid arthritis (RA) patients, and 26 age- and gender-matched healthy controls (HC) were collected from rheumatic clinic of the Second Affiliated Hospital of Zhejiang University, School of Medicine, between March 2015 and July 2015. Demographic data, parameters of ASDAS, and image evaluations of spine (i. Read More

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http://dx.doi.org/10.1007/s10067-018-4356-zDOI Listing
November 2018
1 Read

Late Subaxial Lesion after Overcorrected Occipitocervical Reconstruction in Patients with Rheumatoid Arthritis.

Asian Spine J 2018 Nov 15. Epub 2018 Nov 15.

Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Study Design: Retrospective case-control study, level 4.

Purpose: To clarify the risk factors for late subaxial lesion after occipitocervical (O-C) reconstruction. We examined cases requiring fusion-segment-extended (FE) reconstruction in addition to/after O-C reconstruction. Read More

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http://dx.doi.org/10.31616/asj.2018.0071DOI Listing
November 2018
1 Read

[Cervical spine involvement in rheumatoid arthritis : Diagnostics and treatment of instability due to rheumatism].

Z Rheumatol 2018 Dec;77(10):889-895

Klinik für Neurochirurgie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81679, München, Deutschland.

In addition to involvement of small peripheral joints, the cervical spine is the second most affected body region in rheumatoid arthritis (RA). Due to improvement of pharmaceutical treatment in recent years, new data show that there is a decreasing prevalence of cervical involvement; however, depending on the severity of cervical lesions surgical treatment still plays an important role. The sequelae of involvement of the cervical spine are craniocervical and atlantoaxial instability, which can cause severe pain, neural deficits and even death. Read More

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http://dx.doi.org/10.1007/s00393-018-0564-9DOI Listing
December 2018
4 Reads

High prevalence and correlates of osteoporosis in men aged 50  years and over: A nationwide osteoporosis survey in Taiwan.

Int J Rheum Dis 2018 Dec 5;21(12):2112-2118. Epub 2018 Nov 5.

Department of Kinesiology, Health and Leisure Studies, University of Kaohsiung, Kaohsiung, Taiwan.

Aims: Osteoporosis is one of the consequences of aging, and it remains underdiagnosed and undertreated; this study aimed to present the characteristics and prevalence of osteoporosis in elderly men by conducting a nationwide survey in Taiwan.

Methods: The participants were enrolled between 2008 and 2011, and bone mineral density (BMD) was measured via dual-energy X-ray absorptiometry for the hip (total), lumbar spine (L1-4), and femoral neck (FN). Patients with rheumatoid arthritis, female patients, and those using steroids were excluded. Read More

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http://doi.wiley.com/10.1111/1756-185X.13409
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http://dx.doi.org/10.1111/1756-185X.13409DOI Listing
December 2018
19 Reads

To switch or not to switch: results of a nationwide guideline of mandatory switching from originator to biosimilar etanercept. One-year treatment outcomes in 2061 patients with inflammatory arthritis from the DANBIO registry.

Ann Rheum Dis 2019 Feb 5;78(2):192-200. Epub 2018 Nov 5.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Objectives: Real-world evidence on effectiveness of switching to biosimila r etanercept is scarce. In Denmark, a nationwide guideline of mandatory switch from 50 mg originator (ETA) to biosimilar (SB4) etanercept was issued for patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA) in 2016. Clinical characteristics and treatment outcomes were studied in ETA-treated patients, who switched to SB4 (switchers) or maintained ETA (non-switchers). Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21347
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http://dx.doi.org/10.1136/annrheumdis-2018-213474DOI Listing
February 2019
21 Reads

Biosimilars: complements and comments on the recent statement of the SFR and CRI. Comment on: "Biosimilars: An opportunity. Position statement of the French Rheumatology Society (SFR) and Inflammatory Rheumatic Disease Club (CRI)." Schaeverbeke et al. Joint Bone Spine 2018;95:399-402.

Joint Bone Spine 2018 Oct 27. Epub 2018 Oct 27.

Law and health economics department, faculty of pharmacy, Paris Descartes university, Sorbonne Paris Cité, 4, avenue de l'Observatoire, 75006 Paris, France; Health law institute (Inserm UMR S1145), Paris Descartes university, Sorbonne Paris Cité, 45, rue des Saints-Pères, 75006 Paris, France; Pharmacy department, general agency of equipments and health products (AGEPS), 7, rue du Fer à Moulin, 75005 Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183018
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http://dx.doi.org/10.1016/j.jbspin.2018.10.009DOI Listing
October 2018
6 Reads

Ultrasound of Subtalar Joint Synovitis in Patients with Rheumatoid Arthritis: Results of an OMERACT Reliability Exercise Using Consensual Definitions.

J Rheumatol 2018 Nov 1. Epub 2018 Nov 1.

From MC Groep Hospitals, Lelystad, the Netherlands; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Charles University, Prague, Czech Republic; Hôpital Ambroise Paré, Boulogne-Billancourt, France; Università degli Studi di Torino, Turin; Azienda Ospedaliero Universitaria Pisana, Pisa, Italy; Instituto Nacional de Rehabilitación, Mexico City, Mexico; Diakonhjemmet Hospital, Oslo, Norway; Virginia Mason Medical Center/University of Washington, Seattle, Washington, USA; Hôpital Brabois, Centre Hospitalier Universitaire (CHU) de Nancy, Nancy, France; Rehabilitation Clinical Hospital, Cluj Napoca, Romania; Instituto Poal de Reumatología, Barcelona, Spain; Institute of Rheumatology and Orthopaedics, Royal Prince Alfred Hospital, Sydney, Australia; Cliniques Universitaires Saint-Luc Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium; Japanese Red Cross Medical Center, Tokyo, Japan; Center for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup, Glostrup, Denmark; Clinical Hospital Sf. Maria, Bucharest, Romania; Bergman Clinics, Naarden, the Netherlands. UCB, Celgene, and Janssen-Cilag BV, the Netherlands, provided financial support for the meeting that was the basis of this article. Dr. H.J. Siddle is funded through a Health Education England/National Institute for Health Research Clinical Lectureship. G.A. Bruyn, MD, PhD, MC Groep Hospitals; H.J. Siddle, MD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; P. Hanova, MD, PhD, Charles University; F. Costantino, PhD, Hôpital Ambroise Paré; A. Iagnocco, MD, PhD, Università degli Studi di Torino; A. Delle Sedie, MD, Azienda Ospedaliero Universitaria Pisana; M. Gutierrez, MD, Instituto Nacional de Rehabilitación; H.B. Hammer, MD, PhD, Diakonhjemmet Hospital; E. Jernberg, MD, Virginia Mason Medical Center/University of Washington; D. Loeille, MD, PhD, Hôpital Brabois, CHU de Nancy; M.C. Micu, MD, Rehabilitation Clinical Hospital; I. Moller, MD, PhD, Instituto Poal de Reumatología; C. Pineda, MD, Instituto Nacional de Rehabilitación; B. Richards, MD, Institute of Rheumatology and Orthopaedics, Royal Prince Alfred Hospital; M.S. Stoenoiu, MD, PhD, Cliniques Universitaires Saint-Luc IREC; T. Suzuki, MD, Japanese Red Cross Medical Center; L. Terslev, MD, PhD, Center for Rheumatology and Spine Diseases, Rigshospitalet-Glostrup; V. Vlad, MD, Clinical Hospital Sf. Maria; R. Wonink, Bergman Clinics; M.A. d'Agostino, MD, PhD, Hôpital Ambroise Paré; R.J. Wakefield, MD, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds. Drs. Bruyn and Siddle equally contributed to this work. Address correspondence to Dr. G.A. Bruyn, Department of Rheumatology, MC Groep Hospitals, Ziekenhuisweg 100, 8333 AA Lelystad, the Netherlands. E-mail: Accepted for publication July 26, 2018.

Objective: To evaluate the intraobserver and interobserver reliability of the ultrasonographic (US) assessment of subtalar joint (STJ) synovitis in patients with rheumatoid arthritis (RA).

Methods: Following a Delphi process, 12 sonographers conducted an US reliability exercise on 10 RA patients with hindfoot pain. The anteromedial, posteromedial, and posterolateral STJ was assessed using B-mode and power Doppler (PD) techniques according to an agreed US protocol and using a 4-grade semiquantitative grading score for synovitis [synovial hypertrophy (SH) and signal] and a dichotomous score for the presence of joint effusion (JE). Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.171490
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http://dx.doi.org/10.3899/jrheum.171490DOI Listing
November 2018
8 Reads

Radiographic and clinical outcomes of C1-C2 intra-articular screw fixation in patients with atlantoaxial subluxation.

J Orthop Surg Res 2018 Oct 29;13(1):273. Epub 2018 Oct 29.

Department of Orthopaedic Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo, 173-8610, Japan.

Background: The Magerl and Goel-Harms techniques have been reported to produce excellent treatment outcomes in cases of atlantoaxial subluxation, but they also carry a risk of vertebral artery injuries. In order to completely prevent such injuries, we developed a surgical procedure, involving bone grafting between the C1 posterior arch and C2 lamina with clamp- or hook-and-rod-based fixation combined with the insertion of an interference screw into the posterior atlantoaxial joint.

Methods: This was a retrospective single-center study. Read More

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https://josr-online.biomedcentral.com/articles/10.1186/s1301
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http://dx.doi.org/10.1186/s13018-018-0985-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206642PMC
October 2018
3 Reads

[Surgery for inflammatory rheumatic joint destruction].

Authors:
S Rehart M Henniger

Orthopade 2018 Nov;47(11):933-938

Klinik für Orthopädie und Unfallchirurgie, Orthopädische Rheumatologie, AGAPLESION MARKUS KRANKENHAUS, Akademisches Lehr-KH der Goethe-Universität, Wilhelm-Epstein-Str. 4, 60431, Frankfurt am Main, Deutschland.

Orthopaedic and traumatologic involvement in patients with rheumatic diseases require extensive knowledge of these immunologically impairing illnesses. This concerns both the handling of medication and conservative treatment. The destructive processes of the joints and the spine follow established pathways. Read More

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http://dx.doi.org/10.1007/s00132-018-03657-7DOI Listing
November 2018
10 Reads

Retro-Odontoid Pseudotumor in a Patient with Atlanto-Occipital Assimilation.

J Belg Soc Radiol 2018 Oct 2;102(1):62. Epub 2018 Oct 2.

Ziekenhuis Oost-Limburg, BE.

A retro-odontoid pseudotumor is an uncommon non-neoplastic mass. They are mostly associated with rheumatoid arthritis and atlanto-axial subluxation. The pathogenesis is degeneration of the transverse ligament due to chronic mechanical stress. Read More

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http://jbsr.be/articles/10.5334/jbsr.1587/
Publisher Site
http://dx.doi.org/10.5334/jbsr.1587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174754PMC
October 2018
18 Reads

Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway.

Front Immunol 2018 27;9:2091. Epub 2018 Sep 27.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one of the main components in the Rhizoma of Paris polyphyllin, displays a selective inhibitory effect on various tumor cells. Here we sought to investigate the anti-rheumatoid arthritis effects and mechanisms of PPI on macrophages and . Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02091
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http://dx.doi.org/10.3389/fimmu.2018.02091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170622PMC
September 2018
15 Reads

Magnetic Resonance Imaging in Rheumatology.

Magn Reson Imaging Clin N Am 2018 Nov;26(4):599-613

Department of Radiology and Diagnostic Imaging, University of Alberta, 8440 - 112 Street, Edmonton, Alberta T6G 2B7, Canada.

Magnetic resonance (MR) imaging has traditionally only played a small role in the clinical care of most patients with arthritis. However, with modern therapeutic strategies, early diagnosis is now more important than ever before. Consequently, advanced MRI techniques and applications now play a crucial role in managing an increasing proportion of rheumatology patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10649689183004
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http://dx.doi.org/10.1016/j.mric.2018.06.008DOI Listing
November 2018
11 Reads

Update of French society for rheumatology recommendations for managing rheumatoid arthritis.

Joint Bone Spine 2018 Oct 10. Epub 2018 Oct 10.

Service de rhumatologie, CHU de Montpellier, 34295 Montpellier, France; Université de Montpellier, 34295 Montpellier, France.

The 2014 French Society for Rheumatology (Société Française de Rheumatologie, SFR) recommendations about the management of rheumatoid arthritis (RA) have been updated by a task force composed of 12 expert rheumatologists, 2 patient self-help group representatives, and an occupational therapist. The material used by the task force included recent EULAR recommendations, a systematic literature review, and expert opinion. Four general principles and 15 recommendations were developed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183039
Publisher Site
http://dx.doi.org/10.1016/j.jbspin.2018.10.002DOI Listing
October 2018
24 Reads