3,458 results match your criteria Rheumatoid Arthritis Spine


Predictors of fragility fracture and low bone mineral density in patients with a history of parental fracture.

Osteoporos Sarcopenia 2019 Mar 15;5(1):6-10. Epub 2019 Mar 15.

University Hospitals of Morecambe Bay NHS Foundation Trust, Royal Lancaster Infirmary, Rheumatology, Ashton Road, Lancaster, Lancashire, UK.

Objectives: Bone mineral density (BMD) and fragility fracture (FF) have high heritability, but few data exist on impact of other factors on families with fracture history. We aimed to evaluate predictors of FF and low BMD, in patients with family history of FF.

Methods: This was a retrospective study on patients undergoing dual energy X-ray absorptiometry at a district general hospital (DGH), 2004-2016. Read More

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http://dx.doi.org/10.1016/j.afos.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452922PMC

Blood Loss of Posterior Lumbar Interbody Fusion on Lumbar Stenosis in Patients with Rheumatoid Arthritis: A Case-Control Study.

Spine (Phila Pa 1976) 2019 Mar 26. Epub 2019 Mar 26.

Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China.

Study Design: .: Case-control study OBJECTIVE.: To compare intraoperative bleeding, drainage and hidden blood loss (HBL) of posterior lumbar interbody fusion (PLIF) on lumbar spinal stenosis (LSS) in patients with rheumatoid arthritis (RA) and non-RA and identify the risk factors of HBLwith RA. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003037DOI Listing
March 2019
2 Reads

Is prediction of clinical response to methotrexate in individual rheumatoid arthritis patients possible? A systematic literature review.

Joint Bone Spine 2019 Apr 11. Epub 2019 Apr 11.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands.

Objectives: To identify, by a systematic literature review, predictors of clinical response to methotrexate treatment in rheumatoid arthritis patients, which would facilitate personalised treatment.

Methods: PubMed and Embase databases were searched for original articles. Additionally, congress abstracts of European League Against Rheumatism and American College of Rheumatology annual meetings of the past 2 years were screened. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.04.002DOI Listing
April 2019
1 Read

Systemic rheumatic diseases: From biological agents to small molecules.

Autoimmun Rev 2019 Apr 5. Epub 2019 Apr 5.

Rheumatology Unit, University of Messina, Messina, Italy.

The development of biologics and small oral molecules has recently changed the scenario of pharmacologic treatment of systemic rheumatic diseases and it has become a real revolution. These drugs have innovative mechanisms of action, based on the inhibition of specific molecular or cellular targets directly involved in disease pathogenesis. This new scenario has lead to a regular update of the management recommendations of several institututions, such as those for Rheumatoid Arthritis treatment that address the use of conventional and biologic therapies including TNFin (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab), abatacept, rituximab, IL-6 inhibitors (tocilizumab and sarilumab), biosimilars and small oral molecules (the JAK inhibitors tofacitinib and baricitinib). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15689972193008
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http://dx.doi.org/10.1016/j.autrev.2018.12.009DOI Listing
April 2019
4 Reads

Motivational Counseling and Text Message Reminders: For Reduction of Daily Sitting Time and Promotion of Everyday Physical Activity in People with Rheumatoid Arthritis.

Rheum Dis Clin North Am 2019 May;45(2):231-244

Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg 2000, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.

Most patients with rheumatoid arthritis tend to be physically inactive and spend more time in sedentary behaviors compared with the general population. This inactive lifestyle can lead to serious health consequences, for example, increased risk of cardiovascular disease. For this reason, there is an interest in increasing participation in physical activity in patients with rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2019.01.005DOI Listing
May 2019
3 Reads

Atlanto-axial Pannus in Patients with and without Rheumatoid Arthritis.

J Rheumatol 2019 Apr 1. Epub 2019 Apr 1.

From Spaulding Rehabilitation Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston, USA. Address correspondence to Dr. Joerg Ermann, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital HBTM, Room 06002P, 60 Fenwood Road, Boston, MA 02115 email:

Objective: Pannus formation in the atlanto-axial joint is a well-recognized complication of rheumatoid arthritis (RA). Occasionally, atlanto-axial pannus is reported when patients without a history of RA undergo magnetic resonance imaging (MRI) of the cervical spine. We sought to further characterize these patients. Read More

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http://dx.doi.org/10.3899/jrheum.181429DOI Listing

Impact of red meat, processed meat and fibre intake on risk of late-onset chronic inflammatory diseases: prospective cohort study on lifestyle factors using the Danish 'Diet, Cancer and Health' cohort (PROCID-DCH): .

BMJ Open 2019 Mar 30;9(3):e024555. Epub 2019 Mar 30.

Focused Research Unit for Molecular Diagnostic and Clinical Research, Hospital of Southern Jutland, Aabenraa, Denmark.

Introduction: Chronic inflammatory diseases (CIDs) (Crohn's disease, ulcerative colitis, psoriasis, psoriatic arthritis, rheumatoid arthritis and multiple sclerosis) are diseases of the immune system that have some shared genetic and environmental predisposing factors, but still few studies have investigated the effects of lifestyle on disease risk of several CIDs. The primary aim of this prospective cohort study is to investigate the impact of fibre, red meat and processed meat on risk of late-onset CID, with the perspective that results of this study can contribute in supporting future diet recommendations for effective personalised prevention.

Methods And Analysis: The study will use data from 57 053 persons from the prospective Danish cohort study 'Diet, Cancer and Health' together with National Health Registry data. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024555DOI Listing
March 2019
2 Reads

Rate of remission among rheumatoid arthritis patients being treated by rheumatologists in routine practice.

Joint Bone Spine 2019 Mar 27. Epub 2019 Mar 27.

Department of rheumatology, university hospital Gabriel-Montpied 58, rue Montalembert 63003 Clermont-Ferrand cedex 1, France.

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http://dx.doi.org/10.1016/j.jbspin.2019.03.006DOI Listing
March 2019
3 Reads

Early clinical response and long-term radiographic progression in recent-onset rheumatoid arthritis: Clinical remission within six months remains the treatment target.

Joint Bone Spine 2019 Mar 27. Epub 2019 Mar 27.

Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), 1200 Bruxelles, Belgium; Service de rhumatologie, Cliniques universitaires Saint-Luc, 1200 Bruxelles, Belgium. Electronic address:

Objectives: The primary objective was to evaluate the correlation between 5-year radiographic structural disease progression and early clinical remission in recent-onset rheumatoid arthritis (RA). The secondary objective was to assess the correlation between erosion development in joints free of damage at baseline and early clinical remission.

Methods: A single-center retrospective study was performed in 133 patients meeting ACR criteria for RA of recent onset. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.03.008DOI Listing
March 2019
2 Reads

The Experience of people with rheumatoid arthritis living with fatigue: a qualitative metasynthesis.

BMJ Open 2019 Mar 20;9(3):e024338. Epub 2019 Mar 20.

Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, VRR, Rigshospitalet, Copenhagen, Denmark.

Objectives: To identify, appraise and synthesise qualitative studies on the experience of living with rheumatoid arthritis (RA)-related fatigue.

Methods: We conducted a qualitative metasynthesis encompassing a systematic literature search in February 2017, for studies published in the past 15 years, in PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, SveMed, PsychINFO and Web of Science. To be included, the studies had to report the experience of living with fatigue among adults with RA. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02433
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http://dx.doi.org/10.1136/bmjopen-2018-024338DOI Listing
March 2019
2 Reads

Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli.

J Cell Mol Med 2019 Mar 20. Epub 2019 Mar 20.

Department of Spine, School of Medicine, Honghui-hospital, Xi'an Jiaotong University, Xi'an, China.

Bone homeostasis is preserved by the balance of maintaining between the activity of osteogenesis and osteoclastogenesis. However, investigations for the osteoclastogenesis were hampered by considerable difficulties associated with isolating and culturing osteoclast in vivo. As the alternative, stimuli-induced osteoclasts formation from RAW264. Read More

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http://dx.doi.org/10.1111/jcmm.14277DOI Listing
March 2019
1 Read

Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.

J Adv Res 2019 Jul 18;18:113-126. Epub 2019 Jan 18.

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

The human genome, which includes thousands of genes, represents a big data challenge. Rheumatoid arthritis (RA) is a complex autoimmune disease with a genetic basis. Many single-nucleotide polymorphism (SNP) association methods partition a genome into haplotype blocks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20901232193000
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http://dx.doi.org/10.1016/j.jare.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403413PMC
July 2019
5 Reads

A multicenter, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of Huangqi Guizhi Wuwutang granule in patients with rheumatoid arthritis.

Medicine (Baltimore) 2019 Mar;98(11):e14888

Longhua Hospital, Shanghai University of Traditional Chinese Medicine.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by swelling, pain, and synovial damage. Effective methods lack in the treatment of RA. A traditional prescription in use for thousands of years in China, Huangqi Guizhi Wuwutang granule (HGWG) is still chosen to relieve pain and prevent joint malformation in RA patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000014888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426547PMC
March 2019
1 Read

Imaging in rheumatoid arthritis: the role of magnetic resonance imaging and computed tomography.

Radiol Med 2019 Mar 18. Epub 2019 Mar 18.

Department of Radiology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

In suspected and diagnosed rheumatoid arthritis (RA), magnetic resonance imaging (MRI) allows detection of all relevant pathologies, such as synovitis, tenosynovitis, bone marrow edema (osteitis), bone erosion and cartilage damage. MRI is more sensitive than clinical examination for monitoring disease activity (i.e. Read More

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http://link.springer.com/10.1007/s11547-019-01014-y
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http://dx.doi.org/10.1007/s11547-019-01014-yDOI Listing
March 2019
4 Reads

The OMERACT Stepwise Approach to Select and Develop Imaging Outcome Measurement Instruments: The Musculoskeletal Ultrasound Example.

J Rheumatol 2019 Mar 15. Epub 2019 Mar 15.

From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark; Department of Rheumatology, Bone and Joint Research Unit, Hospital Universitario Fundación Jiménez Díaz, IIS Fundación Jiménez Díaz; Universidad Autónoma de Madrid, Madrid, Spain; Department of Rheumatology, University of Perth, Perth, Australia; Department of Rheumatology, MC Groep Hospitals, Lelystad; Department of Epidemiology and Biostatistics, and Amsterdam Rheumatology and Immunology Center, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands; Dipartimento di Scienze Cliniche e Biologiche (DSCB) Università degli Studi di Torino, Medicina Fisica Riabilitativa Universitaria (MFRU) Città della Salute e della Scienza, Turin, Italy; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; NIHR Leeds Biomedical Research Centre, Leeds, UK; University of Ottawa and Centre for Practice-Changing Research, Ottawa Hospital Research Institute, Ottawa; Institute for Work and Health and Institute for Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Rheumatology Department, AP-HP, Hôpital Ambroise Paré, Boulogne-Billancourt; INSERM U1173, Labex Inflamex, Université Versailles St-Quentin en Yvelines, Montigny Les Bretonneux, France. PGC is supported in part by the UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. L. Terslev, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet; E. Naredo, MD, Department of Rheumatology, Bone and Joint Research Unit, Hospital Universitario Fundación Jiménez Díaz, IIS Fundación Jiménez Díaz, and Universidad Autónoma de Madrid; H.I. Keen, MD, PhD, Department of Rheumatology, University of Perth; G.A. Bruyn, MD, PhD, Department of Rheumatology, MC Groep Hospitals; A. Iagnocco, MD, DSCB Università degli Studi di Torino, MFRU Città della Salute e della Scienza; R.J. Wakefield, MD, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; P.G. Conaghan, MD, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; L.J. Maxwell, PhD, University of Ottawa and Centre for Practice-Changing Research, Ottawa Hospital Research Institute; D.E. Beaton, PhD, Institute for Work and Health and Institute for Health Policy Management and Evaluation, University of Toronto; M. Boers, MD, PhD, Department of Epidemiology and Biostatistics, and Amsterdam Rheumatology and Immunology Center, Amsterdam UMC, Vrije Universiteit; M.A. D'Agostino, MD, PhD, Rheumatology Department, AP-HP, Hôpital Ambroise Paré, and INSERM U1173, Labex Inflamex, Université Versailles St-Quentin en Yvelines. Address correspondence to Prof. M.A. D'Agostino, Rheumatology Department, Ambroise Paré Hospital, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. E-mail: Accepted for publication January 31, 2019.

Objective: To describe the Outcome Measures in Rheumatology (OMERACT) stepwise approach to select and develop an imaging instrument with musculoskeletal ultrasound (US) as an example.

Methods: The OMERACT US Working Group (WG) developed a 4-step process to select instruments based on imaging. Step 1 applies the OMERACT Framework Instrument Selection Algorithm (OFISA) to existing US outcome measurement instruments for a specific indication. Read More

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http://dx.doi.org/10.3899/jrheum.181158DOI Listing
March 2019
1 Read

Properties of FDA-approved small molecule protein kinase inhibitors.

Authors:
Robert Roskoski

Pharmacol Res 2019 Mar 13;144:19-50. Epub 2019 Mar 13.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC 28742-8814, United States. Electronic address:

Because mutations, overexpression, and dysregulation of protein kinases play essential roles in the pathogenesis of many illnesses, this enzyme family has become one of the most important drug targets in the past 20 years. The US FDA has approved 48 small molecule protein kinase inhibitors, nearly all of which are orally effective with the exceptions of netarsudil (which is given as an eye drop) and temsirolimus (which is given intravenously). Of the 48 approved drugs, the majority (25) target receptor protein-tyrosine kinases, ten target non-receptor protein-tyrosine kinases, and 13 target protein-serine/threonine protein kinases. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.006DOI Listing
March 2019
1 Read

Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2019 Mar 15. Epub 2019 Mar 15.

University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.

Objective: In rheumatoid arthritis (RA), it is unclear if women are less likely to achieve low disease activity (LDA). We evaluated sex differences in remission and LDA, comparing different clinical and imaging measures.

Methods: We utilized data from the Veterans Affairs RA (VARA) registry and from two clinical trials. Read More

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http://dx.doi.org/10.1002/acr.23873DOI Listing
March 2019
5 Reads
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Atlantoaxial instability in a patient with neck pain and rheumatoid arthritis.

J Spinal Cord Med 2019 Mar 15:1-4. Epub 2019 Mar 15.

c Department of Radiology , University of Texas Health Science Center at San Antonio , San Antonio , Texas , USA.

Context: The purpose of this report is to describe the clinical decision-making process for a patient with rheumatoid arthritis with neck pain with underlying atlantoaxial instability.

Findings: The patient was evaluated for worsening upper neck pain that began insidiously 1 year prior. The patient denied numbness or tingling in her upper or lower extremities, dizziness or lightheadedness, difficulty maintaining balance with walking, or muscle weakness. Read More

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http://dx.doi.org/10.1080/10790268.2019.1580859DOI Listing

Thinking beyond pannus: a review of retro-odontoid pseudotumor due to rheumatoid and non-rheumatoid etiologies.

Skeletal Radiol 2019 Mar 13. Epub 2019 Mar 13.

Department of Radiology, Division of Musculoskeletal Imaging and Intervention, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.

Retro-odontoid pseudotumor, or mass-like retro-odontoid soft tissue thickening, is an uncommon but important imaging finding that may be associated with rheumatoid arthritis, crystal deposition diseases, as well as non-inflammatory conditions such as cervical degenerative changes and mechanical alterations. Retro-odontoid pseudotumor is commonly associated with atlantoaxial microinstability or subluxation. MRI and CT have an important role in the detection and diagnosis of retro-odontoid pseudotumor. Read More

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http://dx.doi.org/10.1007/s00256-019-03187-zDOI Listing
March 2019
1 Read

Prevalence of and factors associated with dysfunctional low back pain in patients with rheumatoid arthritis.

Eur Spine J 2019 Mar 8. Epub 2019 Mar 8.

Division of Orthopaedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Purpose: To investigate the prevalence of and factors associated with dysfunctional low back pain (LBP) in patients with rheumatoid arthritis (RA).

Methods: This cross-sectional study included 1276 RA outpatients from two hospitals. The Roland-Morris Disability Questionnaire was used to address the functional-dysfunctional state criterion. Read More

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http://dx.doi.org/10.1007/s00586-019-05938-xDOI Listing
March 2019
1 Read

Perioperative outcomes associated with thoracolumbar 3-column osteotomies for adult spinal deformity patients with rheumatoid arthritis.

J Neurosurg Spine 2019 Mar 1:1-11. Epub 2019 Mar 1.

Departments of1Neurological Surgery and.

OBJECTIVESpinal deformity causing spinal imbalance is directly correlated to pain and disability. Prior studies suggest adult spinal deformity (ASD) patients with rheumatoid arthritis (RA) have more complex deformities and are at higher risk for complications. In this study the authors compared outcomes of ASD patients with RA following thoracolumbar 3-column osteotomies to outcomes of a matched control cohort. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18927DOI Listing
March 2019
6 Reads

The effect of periodontal treatment on patients with rheumatoid arthritis: The ESPERA randomised controlled trial.

Joint Bone Spine 2019 Feb 26. Epub 2019 Feb 26.

Paul Sabatier University, Dental Faculty, Toulouse University Hospital (CHU de Toulouse), 31062 Toulouse, France; Department of epidemiology and public health, Dental Faculty, 31062 Toulouse, France; Division of oral health and society, faculty of dentistry, McGill university, Montreal, Quebec H3A 0C7, Canada.

Objectives: To assess the effect of periodontal treatment on clinical and biochemical parameters of rheumatoid arthritis (RA) and quality of life (QoL) in patients with moderately active RA who were diagnosed with periodontitis.

Methods: In this open-label randomised controlled trial, RA subjects (n = 22) were allocated to "immediate" or "delayed" periodontal treatment (full-mouth non-surgical scaling and root planing, systemic antibiotics, and oral hygiene instructions). The main outcome was the 3-month change on the Disease Activity Score 28 based on the Erythrocyte Sedimentation Rate (DAS28-ESR). Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.02.006DOI Listing
February 2019
4 Reads

[Chirurgiczne leczenie uszkodzeń połączenia czaszkowokręgosłupowego].

Pol Merkur Lekarski 2019 Jan;46(271):20-24

Department of Neuroortopedics, Mazovian Rehabilitation Center STOCER, Konstancin-Jeziorna, Poland.

Damages of the cranio-vertebral junction include bone and ligamentous structures. Due to the unique design of the C0-C1-C2 complex and biomechanical properties, they represent a major surgical challenge. Treatment of damage to this area involves decompression of nerve structures with simultaneous occipito-cervical fixation from posterior access. Read More

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January 2019

Hand, foot, and spine deformities in parkinsonian disorders.

J Neural Transm (Vienna) 2019 Mar 27;126(3):253-264. Epub 2019 Feb 27.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 7200 Cambridge St, Suite #9A, Houston, TX, 77030, USA.

Hand and foot deformities, known as "striatal deformities", and other musculoskeletal abnormalities such as dropped head, bent spine, camptocormia, scoliosis and Pisa syndrome, are poorly understood and often misdiagnosed features of Parkinson's disease and other parkinsonian syndromes. These deformities share some similarities with known rheumatologic conditions and can be wrongly diagnosed as rheumatoid arthritis, osteoarthritis, psoriatic arthritis, Dupuytren's contracture, trigger finger, or other rheumatologic or orthopedic conditions. Neurologists, rheumatologists, and other physicians must be familiar with these deformities to prevent misdiagnosis and unnecessary diagnostic tests, and to recommend appropriate treatment options. Read More

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http://dx.doi.org/10.1007/s00702-019-01986-1DOI Listing
March 2019
3 Reads

Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes.

Front Pharmacol 2019 12;10:94. Epub 2019 Feb 12.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Astragalin, as a bioactive flavonoid with anti-inflammatory, antioxidant, and protective properties, provides a potential agent for rheumatoid arthritis (RA). In this study, its therapeutic efficacy and the underlying mechanisms were explored using DBA/1J mice with collagen-induced arthritis (CIA). It was demonstrated that astragalin could significantly attenuate inflammation of CIA mice. Read More

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http://dx.doi.org/10.3389/fphar.2019.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379316PMC
February 2019
1 Read

Predicting risk for radiographic damage in rheumatoid arthritis: comparative analysis of the multi-biomarker disease activity score and conventional measures of disease activity in multiple studies.

Curr Med Res Opin 2019 Mar 14:1-11. Epub 2019 Mar 14.

h Leiden University Medical Center , Leiden , Netherlands.

Objective: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis.

Methods: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: <30, 30-44, >44), DAS28-CRP (low/moderate/high: ≤2. Read More

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http://dx.doi.org/10.1080/03007995.2019.1585064DOI Listing
March 2019
8 Reads

Validity and Responsiveness of Combined Inflammation and Combined Joint Damage Scores Based on the OMERACT Rheumatoid Arthritis MRI Scoring System (RAMRIS).

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Rheumatology, Diakonhjemmet Hospital; Institute of Health and Society, University of Oslo, Oslo, Norway; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen; King Christian 10th Hospital for Rheumatic Diseases; University of Southern Denmark, Institute of Regional Health Research, Graasten; Institute of Clinical Medicine, Aarhus University Hospital, Århus; Odense University Hospital; Institute of Clinical Research, University of Southern Denmark, Odense; Zealand University Hospital, Køge, Denmark; University of New South Wales, Sydney, Australia; Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, UK. U. Sundin, MD, Research Fellow, Department of Rheumatology, Diakonhjemmet Hospital, and Institute of Health and Society, University of Oslo; M. Østergaard, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and the Department of Clinical Medicine, University of Copenhagen; D. Glinatsi, MD, PhD, Postdoctoral Researcher, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; A.B. Aga, MD, PhD, Senior Consultant and Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital Oslo; K. Hørslev-Petersen, MD, DMSc, Professor, Senior Consultant, King Christian 10th Hospital for Rheumatic Diseases, and the Institute of Regional Health Research, University of Southern Denmark; M.L. Hetland, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and the Department of Clinical Medicine, University of Copenhagen; K. Stengaard-Pedersen, MD, DMSc, Professor Emeritus, Institute of Clinical Medicine, Aarhus University Hospital; P. Junker, MD, DMSc, Professor, Department of Rheumatology, Odense University Hospital and Institute of Clinical Research, University of Southern Denmark; B.J. Ejbjerg, MD, PhD, Chief Consultant, Zealand University Hospital; P. Bird, BMed (Hons), FRACP, PhD, Grad Dip MRI, Associate Professor, University of New South Wales; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; S. Lillegraven, MD, MPH, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital; E.A. Haavardsholm, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, and Institute of Health and Society, University of Oslo. Address correspondence to Dr. U. Sundin, Diakonhjemmet Sykehus, Diakonveien 12, 0370 Oslo, Norway. E-mail: Accepted for publication December 6, 2018.

Objective: The RAMRIS [Outcome Measures in Rheumatology rheumatoid arthritis (RA) magnetic resonance imaging (MRI) Scoring system] is used in clinical RA trials. We have investigated methods to combine the RAMRIS features into valid and responsive scores for inflammation and joint damage.

Methods: We used data from 3 large randomized early RA trials to assess 5 methods to develop a combined score for inflammation based on RAMRIS bone marrow edema, synovitis, and tenosynovitis scores, and a combined joint damage score based on erosions and joint space narrowing. Read More

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http://dx.doi.org/10.3899/jrheum.181064DOI Listing
February 2019
4 Reads

Conventional synthetic disease-modifying antirheumatic drugs and bone mineral density in rheumatoid arthritis patients with osteoporosis: possible beneficial effect of leflunomide.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Rheumatology, Department of Medicine, University of Ulsan, College of Medicine, Asan Medical Centre, Seoul, Korea.

Objectives: To investigate the effect of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) on bone mineral density (BMD) in rheumatoid arthritis (RA) patients with osteoporosis.

Methods: Patients with RA who were newly diagnosed with osteoporosis (T-score ≤ -2.5) between 2010 and 2017 were included. Read More

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February 2019
1 Read

Correction: Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Pharmacogenomics J 2019 Feb 14. Epub 2019 Feb 14.

Genomic Oncology Area, GENYO Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada, Granada, Spain.

The original version of this Article contained an error in the spelling of the author Ana Rodríguez-Ramos, which was incorrectly given as Ana Rodríguez Ramos. This has now been corrected in both the PDF and HTML versions of the Article. Read More

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http://dx.doi.org/10.1038/s41397-019-0084-2DOI Listing
February 2019
3 Reads

Bortezomib improved the joint manifestations of rheumatoid arthritis in three patients.

Joint Bone Spine 2019 Feb 6. Epub 2019 Feb 6.

Service de rhumatologie, centre hospitalier Jean-Rougié Cahors 46000, France.

The proteasome inhibitor bortezomib has been proven effective in the treatment of multiple myeloma. We report on 3 patients with rheumatoid arthritis and multiple myeloma in whom bortezomib therapy was associated with improvements in the joint manifestations. The contribution to this effect of the concomitant glucocorticoid therapy is discussed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X193001
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http://dx.doi.org/10.1016/j.jbspin.2019.01.019DOI Listing
February 2019
12 Reads

The efficacy of the traditional Chinese medicine Jia Wei Niu Bang Zi granule combined with methotrexate in treating active rheumatoid arthritis: A multicenter, randomized, double-blinded controlled clinical trial.

Medicine (Baltimore) 2019 Feb;98(6):e14424

Longhua Hospital, Shanghai University of Traditional Chinese Medicine.

Background: Rheumatoid arthritis (RA) is a chronic systemic and autoimmune inflammatory disease ending with the destruction of joints. Current therapies can relieve RA symptoms, but some also bring severe adverse events. Therefore, an effective and safe therapeutic strategy remains to be created to benefit patients with RA by large. Read More

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http://dx.doi.org/10.1097/MD.0000000000014424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380764PMC
February 2019
9 Reads
5.723 Impact Factor

Increased antibody levels to stage-specific Epstein-Barr virus antigens in systemic autoimmune diseases reveal a common pathology.

Scand J Clin Lab Invest 2019 Feb 6:1-10. Epub 2019 Feb 6.

h Department of Autoimmunology and Biomarkers , Statens Serum Institut , Copenhagen , Denmark.

The immune responses to antigens from different stages of the Epstein-Barr virus (EBV) life cycle were investigated in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SS), and systemic sclerosis (SSc) to gain knowledge of EBV's involvement in the etiology of systemic autoimmune diseases (SADs) and for an overview of the humoral immune responses against EBV. Investigations were performed by the use of ELISA. IgM, IgA, and IgG antibody binding to 11 EBV antigens: EBNA1, EBNA2, BALF5, EAD, BALF2, EA/R, VCA p18, VCA p23, gB, gp350, and gp42 were examined in serum pools from SAD patients and healthy controls (HCs). Read More

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http://dx.doi.org/10.1080/00365513.2018.1550807DOI Listing
February 2019
2 Reads

Effect of Magnetic Resonance Imaging vs Conventional Treat-to-Target Strategies on Disease Activity Remission and Radiographic Progression in Rheumatoid Arthritis: The IMAGINE-RA Randomized Clinical Trial.

JAMA 2019 02;321(5):461-472

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.

Importance: Whether using magnetic resonance imaging (MRI) to guide treatment in patients with rheumatoid arthritis (RA) improves disease activity and slows joint damage progression is unknown.

Objective: To determine whether an MRI-guided treat-to-target strategy vs a conventional clinical treat-to-target strategy improves outcomes in patients with RA in clinical remission.

Design, Setting, And Participants: Two-year, randomized, multicenter trial conducted at 9 hospitals in Denmark. Read More

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http://dx.doi.org/10.1001/jama.2018.21362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440221PMC
February 2019
4 Reads

Anti-citrullinated protein antibodies are associated with osteopenia but not with pain at diagnosis of rheumatoid arthritis: data from the BARFOT cohort.

Arthritis Res Ther 2019 Feb 4;21(1):45. Epub 2019 Feb 4.

Department of Clinical Science, Section of Rheumatology, Faculty of Medicine Lund University, Lund, Sweden.

Background: Anti-citrullinated protein antibodies (ACPA) have been suggested to have a potential role in both bone loss and pain in rheumatoid arthritis (RA), based on studies in vitro and in animal models. Here we addressed if anti-cyclic citrullinated (anti-CCP) antibodies were associated with osteopenia or pain in patients with RA, at the time for diagnosis.

Methods: Baseline data from the BARFOT (Better Anti-Rheumatic PharmacOTherapy) cohort, which consists of patients with RA with a disease duration of 1 year or less, were analyzed. Read More

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http://dx.doi.org/10.1186/s13075-019-1833-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360733PMC
February 2019
4 Reads

Corneal and scleral involvement in inflammatory rheumatic disease: Rheumatologists and ophthalmologists exchanging views.

Joint Bone Spine 2019 Feb 1. Epub 2019 Feb 1.

Inserm UMR 1125, 1, rue de Chablis, 93017 Bobigny, France; Service de rhumatologie, assistance publique-Hôpitaux de Paris (AP-HP), groupe hospitalier Avicenne Jean-Verdier-René-Muret, 125, rue de Stalingrad, 93017 Bobigny, France.

Corneal and scleral disorders related to inflammatory rheumatic diseases vary both in frequency and in severity. Sicca syndrome and its complications are the most common ocular manifestations and, together with episcleritis, can usually be managed by topical treatments. In contrast, the various forms of scleritis and peripheral ulcerative keratitis generally require systemic glucocorticoid therapy and the initiation or intensification of immunosuppressive treatment. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.014DOI Listing
February 2019

Ultrasonographic criteria for the diagnosis of erosive rheumatoid arthritis using osteoarthritic patients as controls compared to validated radiographic criteria.

Joint Bone Spine 2019 Jan 31. Epub 2019 Jan 31.

Department of rheumatology, university hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France; Inserm, CIC-EC CIE6, university hospital of Nancy, epidemiology and clinical evaluation, 54500 Vandoeuvre-lès-Nancy, France.

Objectives: The aims of this study were to compare characteristics of radiography (RX) and ultrasound (US) erosive lesions in rheumatoid arthritis (RA) and osteoarthritis (OA) patients (prevalence, topography and severity), to determine thresholds for the diagnosis of erosive RA based on US and to evaluate the performance of US and RX to establish a diagnosis of erosive RA differentiated from hand OA.

Methods: Patients fulfilling ACR 1987 and/or ACR/EULAR 2010 criteria for RA or ACR hand OA criteria were prospectively included. A modified Sharp erosion score was assessed by two blinded readers and one adjudicator for discordant cases (number of eroded joints ≤ three). Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.011DOI Listing
January 2019
2 Reads

Comorbidities in inflammatory joint and spine diseases in XXI century.

Ter Arkh 2018 Dec;90(12):90-95

V.I. Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation, Saratov, Russia.

Aim: The evaluation the occurrence of comorbidities in patients with inflammatory diseases of the spine and joints and the assessment of the general changes in comorbidities at the beginning of the XXI century compared to previous period.

Materials And Methods: Comorbidity was analyzed in 245 patients with spondyloarthritis who participated in the scientific program PROGRESS. Validated comorbidity assessment indices were used in the study. Read More

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http://ter-arkhiv.ru/en/archive/2018/vol-90-12-2018/comorbid
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http://dx.doi.org/10.26442/00403660.2018.12.000015DOI Listing
December 2018
8 Reads

Pathogenic effects of anti-citrullinated protein antibodies in rheumatoid arthritis - role for glycosylation.

Joint Bone Spine 2019 Jan 25. Epub 2019 Jan 25.

Service d'immunologie, Pierre-Bénite, hospices civils de Lyon, CHU de Lyon-sud, 165, chemin du Grand Revoyet, 69310 Pierre-Bénite, France; Unité d'immunogénomique et inflammation, EA4130, Hôpital Edouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France; Faculté de médecine Lyon-Est, université de Lyon, 8, avenue Rockefeller, 69008 Lyon, France. Electronic address:

The identification in 1998 of the main antigenic substrate recognized by autoantibodies was a dramatic turning point in our understanding of rheumatoid arthritis (RA) biology. Now, two decades later, antibodies to citrullinated proteins are viewed no longer as mere biomarkers for RA, but also as major pathophysiological factors involved in the development of bone loss and joint pain. These pathogenic effects are ascribable to abnormal autoantibody glycosylation via a pathway involving the Th17T cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X193000
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http://dx.doi.org/10.1016/j.jbspin.2019.01.005DOI Listing
January 2019
7 Reads
2.901 Impact Factor

Odontoid cervical gout causing atlantoaxial instability: case report.

J Neurosurg Spine 2019 Jan 25:1-4. Epub 2019 Jan 25.

Departments of1Neurosurgery and.

The authors present a case report of a patient discovered to have a rotatory subluxation of the C1-2 joint and a large retroodontoid pannus with an enhancing lesion in the odontoid process eventually proving to be caused by gout. This patient represented a diagnostic conundrum as she had known prior diagnoses of not only gout but also sarcoidosis and possible rheumatoid arthritis, and was in the demographic range where concern for an oncological process cannot fully be ruled out. Because she presented with signs and symptoms of atlantoaxial instability, she required posterior stabilization to reduce the rotatory subluxation and to stabilize the C1-2 instability. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18122DOI Listing
January 2019
15 Reads

Hypertrophic cervical spine pachymeningitis due to sarcoidosis: a case report.

Hosp Pract (1995) 2019 Apr 6;47(2):99-103. Epub 2019 Feb 6.

d Pathology , Lehigh Valley Health Network , Allentown , PA , USA.

Hypertrophic pachymeningitis (HP) is a chronic, progressive diffuse inflammatory condition that leads to thickening of the dura mater and can be idiopathic or associated with sarcoidosis among other disorders. In this case report, we present a rare case of cervical spine HP in a 29-year-old woman in the post-partum period, who had a history of pituitary adenoma and juvenile rheumatoid arthritis. Magnetic resonance imaging (MRI) of the spine revealed a soft tissue mass and moderate cord compression. Read More

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https://www.tandfonline.com/doi/full/10.1080/21548331.2019.1
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http://dx.doi.org/10.1080/21548331.2019.1575645DOI Listing
April 2019
14 Reads

Reduction in Upper Limb Joint Surgery among Rheumatoid Arthritis Patients: An Interrupted Time Series Analysis using Danish Health Care Registers.

Arthritis Care Res (Hoboken) 2019 Jan 25. Epub 2019 Jan 25.

Center for Rheumatology and Spine Diseases, Rigshospitalet - Gentofte, Copenhagen, Denmark.

Objectives: Joint replacement surgery is a proxy of severe joint damage in rheumatoid arthritis (RA). The aim of this study was to assess the impact of the introduction of biological DMARDs (bDMARDs) on the incidence rate (IR) of upper limb joint replacements among newly diagnosed RA patients.

Methods: Using the Danish National Patient Register, incident RA patients from 1996-2012 were identified. Read More

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http://dx.doi.org/10.1002/acr.23835DOI Listing
January 2019
3 Reads

Outcomes of Minimally Invasive Oblique Lumbar Interbody Fusion in Patients with Lumbar Degenerative Disease with Rheumatoid Arthritis.

J Neurol Surg A Cent Eur Neurosurg 2019 May 24;80(3):162-168. Epub 2019 Jan 24.

Department of Neurosurgery, Seoul St. Mary's Hospital, Seoul, The Republic of Korea.

Purpose Of Study:  Standard treatment protocols for lumbar degenerative lesions in the setting of rheumatoid arthritis (RA) are lacking. The purpose of this study was to evaluate the clinical and radiologic outcomes of minimally invasive oblique lumbar interbody fusion (MI-OLIF) in RA patients having degenerative lumbar spine lesions.

Methods:  This was a retrospective hospital-based case series (evidence level 4). Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676301
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http://dx.doi.org/10.1055/s-0038-1676301DOI Listing
May 2019
10 Reads

Translocation of dead or alive bacteria from mucosa to joints and epiphyseal bone-marrow: facts and hypotheses.

Joint Bone Spine 2019 Jan 21. Epub 2019 Jan 21.

Rheumatology unit, CHRU de Besançon, and EA4266 (Pathogens and inflammation, EPILAB) université Bourgogne Franche-Comté, boulevard Fleming, 25030 Besançon, France.

The recent demonstration that DNA from several mucosal bacteria, including Prevotella spp, could be found in numerous tissues (mesenteric lymph nodes, spleen, serum, liver, lung, eye and ankle joints), either in HLA-B27 rats with or without arthritis, or control rats without HLA-B27, could be a revolution in our understanding of spondyloarthritis and close disorders, including rheumatoid arthritis. Indeed, similar translocations of dead or alive bacteria or fungi from mucosa to joints, could contribute to the onset and flares of inflammatory rheumatisms. This state of the art article addresses six questions revived by this finding: 1-How does this bacterial DNA or living bacteria traffic from mucosa to joints? 2-Can some mucosal bacteria remain alive in those tissues, including joints? 3-Could bacteria from the gut microbiota ('self-bacteria') protect the host cells from invasion by more pathogenic bacteria (like dog-shepherds protect from wolves)? 4-Does the composition of the joint or bone marrow microbiota depends on local metabolism, which might differ from gut metabolism? 5-Could bacterial antigens from mucosal microbiota be sufficient to trigger trained immunity of presenting cells in joints, or does such phenomenon (with lasting epigenetic changes of presenting cells) require intra-cellular infection of presenting cells or their ancestors? 6-In which subsets of cells could living bacteria preferentially persist for a long period in the joint area? Transient or dormant infections within bone-marrow mesenchymal stem cells leading to trained immunity of some of their daughter cells in joints or enthesis, lasting after clearance or the invader, is an attractive hypothesis to test. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.004DOI Listing
January 2019
11 Reads

Systemic calprotectin and chronic inflammatory rheumatic diseases.

Joint Bone Spine 2019 Jan 17. Epub 2019 Jan 17.

GREPI, EA 7408, University Grenoble Alpes, 38700 La Tronche, France; Sinnovial SAS, avenue de Kimberley, 38130 Échirolles, France.

Calprotectin is a calcium binding protein produced by neutrophils and monocytes locally at the site of inflammation in order to trigger the innate immunity receptors. This unique characteristic makes it a good proxy for evaluation of local inflammation in chronic inflammatory rheumatic diseases. Complete data suggest, in inflammatory rheumatic diseases, a relevant role of calprotectin in the inflammatory process. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1297319X183034
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http://dx.doi.org/10.1016/j.jbspin.2019.01.003DOI Listing
January 2019
18 Reads

Impact of TNF inhibitor therapy on joint replacement rates in rheumatoid arthritis: a matched cohort analysis of BSRBR-RA UK registry data.

Rheumatology (Oxford) 2019 Jan 10. Epub 2019 Jan 10.

Pharmaco- and Device-Epidemiology Group, Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford.

Objectives: Previous ecological data suggest a decline in the need for joint replacements in RA patients following the introduction of TNF inhibitor (TNFi) therapy, although patient-level data are lacking. Our primary aim was to estimate the association between TNFi use and subsequent incidence of total hip replacement (THR) and total knee replacement.

Methods: A propensity score matched cohort was analysed using the British Society for Rheumatology Biologics Registry (2001-2016) for RA data. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key424DOI Listing
January 2019
9 Reads

[A strategy of combining posterior occipitocervical angle with occipital-C angle for adjustment of occipitocervical fixation angle in posterior instrumented occipitocervical fusion].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 01;33(1):35-40

Operating Room, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To assess the application and the effectiveness of a strategy of combining posterior occipitocervical angle (POCA) with occipital-C (O-C ) angle for adjustment of occipitocervical fixation angle in posterior instrumented occipitocervical fusion.

Methods: The clinical data of 22 patients undergoing posterior instrumented occipitocervical fusions between March 2013 and January 2016 were retrospectively analysed, and all patients were performed by using a strategy combining with POCA and O-C angle for adjustment of occipitocervical fixation angle. All patients suffered from occipitocervical instability, including 7 males and 15 females with an average age of 44. Read More

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http://www.rrsurg.com/article/10.7507/1002-1892.201807115
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http://dx.doi.org/10.7507/1002-1892.201807115DOI Listing
January 2019
14 Reads

Prevalent vertebral fracture on bone density lateral spine (VFA) images in routine clinical practice predict incident fractures.

Bone 2019 Apr 8;121:72-79. Epub 2019 Jan 8.

University of Manitoba, Winnipeg, Canada.

Purpose: The predictive validity of vertebral fracture assessment (VFA) on bone density lateral spine images to identify prevalent vertebral fractures in routine clinical practice has not been established. Our objective was to estimate the associations of prevalent vertebral fracture identified on VFA images in routine practice with incident hip, all non-vertebral, major osteoporotic, and clinical vertebral fractures, using the Manitoba Bone Density database.

Methods: From 2010 onward, 9972 men and women (mean age [SD] 76 [6. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S87563282193000
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http://dx.doi.org/10.1016/j.bone.2019.01.009DOI Listing
April 2019
16 Reads

Risk of serious infections in patients with rheumatoid arthritis treated in routine care with abatacept, rituximab and tocilizumab in Denmark and Sweden.

Ann Rheum Dis 2019 Mar 5;78(3):320-327. Epub 2019 Jan 5.

DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen, Denmark.

Objective: To estimate (1) crude and age-and gender-adjusted incidence rates (IRs) of serious infections (SI) and (2) relative risks (RR) of SI in patients with rheumatoid arthritis (RA) initiating treatment with abatacept, rituximab or tocilizumab in routine care.

Methods: This is an observational cohort study conducted in parallel in Denmark and Sweden including patients with RA in Denmark (DANBIO) and Sweden (Anti-Rheumatic Treatment in Sweden Register/Swedish Rheumatology Quality Register) who started abatacept/rituximab/tocilizumab in 2010-2015. Patients could contribute to more than one treatment course. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21432
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http://dx.doi.org/10.1136/annrheumdis-2018-214326DOI Listing
March 2019
49 Reads

The Craniovertebral Junction in Rheumatoid Arthritis: State of the Art.

Acta Neurochir Suppl 2019;125:79-86

Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, Neurosurgical Clinic, University of Palermo, Palermo, Italy.

Rheumatoid arthritis (RA) is a chronic inflammatory disorder, characterized by polyarticular inflammation causing progressive joint damage and disability. The mechanisms underlying its pathogenesis involve activation of innate and adaptive immunity, microvascular endothelial cell activation, and inflammatory infiltration of lymphocytes and monocytes into the synovium. Spinal involvement in RA is not typical; when it occurs, the main radiological features are (1) atlantoaxial subluxation (AAS), which is the most typical form of cervical spine involvement; (2) cranial settling-also known as basilar impression, atlantoaxial impaction or superior migration of the odontoid-which is the most severe form of associated spinal instability; and (3) subaxial subluxation. Read More

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http://dx.doi.org/10.1007/978-3-319-62515-7_12DOI Listing
January 2019
4 Reads

Survivorship and long-term outcome of a consecutive series of 200 Scandinavian Total Ankle Replacement (STAR) implants.

Bone Joint J 2019 Jan;101-B(1):47-54

Wrightington Hospital, Wigan, UK.

Aims: We report the long-term clinical and radiological outcomes of a consecutive series of 200 total ankle arthroplasties (TAAs, 184 patients) at a single centre using the Scandinavian Total Ankle Replacement (STAR) implants.

Patients And Methods: Between November 1993 and February 2000, 200 consecutive STAR prostheses were implanted in 184 patients by a single surgeon. Demographic and clinical data were collected prospectively and the last available status was recorded for further survival analysis. Read More

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http://dx.doi.org/10.1302/0301-620X.101B1.BJJ-2018-0801.R1DOI Listing
January 2019
3 Reads