3,850 results match your criteria Rheumatoid Arthritis Spine


Efficacy and safety of intra-articular therapies in rheumatic and musculoskeletal diseases: an overview of systematic reviews.

RMD Open 2021 Jun;7(2)

InMusc, Madrid, Spain.

Objective: To summarise the evidence on intra-articular therapies (IAT) to inform the 2020 EULAR recommendations.

Methods: An overview of systematic reviews (SR) including randomised-controlled trials (RCTs) of IAT in adults with arthropathies was performed up to July 2020. Pain, function, and frequency of adverse events were the main efficacy and safety outcomes, respectively. Read More

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Palindromic rheumatism: Evidence of four subtypes of palindromic-like arthritis based in either MEFV or RF/ACPA status.

Joint Bone Spine 2021 Jun 4:105235. Epub 2021 Jun 4.

Hospital Clínic. Arthritis Unit. Department of Rheumatology. University of Barcelona and IDIBAPS, Barcelona, Spain. Electronic address:

Introduction: MEFV mutations have been documented in patients with palindromic rheumatism (PR) who do not meet FMF criteria, and RF and ACPA positive RA may start with PR.

Objective: To analyze the clinical phenotype and disease evolution of patients with intermittent, palindromic-like (PL) arthritis seen in our Arthritis Unit according to the RF, ACPA and MEFV mutation status.

Methods: MEFV genotyping was done in 76 patients with PL arthritis as defined by predominantly short attacks (<7 days) and a relapsing course. Read More

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Alcohol intake prevents structural damage for male but not female patients with rheumatoid arthritis: systematic review of the literature and meta-analysis.

Joint Bone Spine 2021 Jun 4:105233. Epub 2021 Jun 4.

Rheumatology Department, Hôpital Sud, Grenoble Teaching Hospital, 38130 Echirolles, France; Univ. Grenoble Alpes, GREPI TIMC, UMR 5525, 38100 Grenoble, France.

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Fluorescence optical imaging: ready for prime time?

RMD Open 2021 Jun;7(2)

Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt - Universität zu Berlin, Freie Universität Berlin, Berlin, Germany

The novel technique of fluorescence optical imaging (FOI, Xiralite), which is approved in the European Union and the USA for clinical use, has been the object of studies since 2009. Indocyanine green-based FOI can demonstrate an impaired microcirculation caused by inflammation in both hands in one examination. Several studies have investigated FOI for detection of joint inflammation by comparing FOI to magnetic resonance imaging (MRI) and/or musculoskeletal ultrasound (MSUS). Read More

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Ononin induces cell apoptosis and reduces inflammation in rheumatoid arthritis fibroblast-like synoviocytes by alleviating MAPK and NF-κB signaling pathways.

Acta Biochim Pol 2021 Jun;68(2):239-245

Department of Joint Surgery, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, 510900, China.

As a kind of chronic inflammatory diseases, Rheumatoid arthritis (RA) has a low cure rate and easy recurrence. It has widely reported that abnormal activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling pathways are associated with the development of RA inflammation. Blocking the inflammatory signaling pathways of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) can delay the development of RA. Read More

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Reproducibility and diagnostic value of a new method using ratios to diagnose anterior atlanto-axial subluxation on plain radiographs.

Joint Bone Spine 2021 May 26:105229. Epub 2021 May 26.

Service de rhumatologie, CHU Brest, INSERM 1227, Université de Bretagne Occidentale, LabEx IGO, Brest, France. Electronic address:

Objectives: Measures on conventional radiography are used to detect, especially in rheumatoid arthritis, upper cervical spine instabilities (CSIs) with the anterior and posterior atlanto-dental intervals (AADI and PADI) measurements. Our objective was to evaluate the diagnostic performance and reliability of AADIs and PADIs extrapolated based on ratios in assessing anterior atlanto-axial subluxation (aAAS) when plain radiographs do not allow the measures.

Methods: Radiographies of 119 patients were randomly selected. Read More

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Rheumatoid arthritis and osteoporosis: a bi-directional Mendelian randomization study.

Aging (Albany NY) 2021 05 18;13(10):14109-14130. Epub 2021 May 18.

Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, China.

Many observation studies have demonstrated a close relationship between rheumatoid arthritis (RA) and osteoporosis (OP). However, the causal genetic correlation between RA and OP remains unclear. In this study, we performed bi-directional Mendelian randomization (MR) analyses to explore causal inference between these two traits. Read More

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Association between ischemic stroke and seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study.

PLoS One 2021 17;16(5):e0251851. Epub 2021 May 17.

Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam, Gyeonggi-do, South Korea.

The purpose of this longitudinal follow-up study was to investigate the risk of ischemic stroke nationwide in patients with seropositive rheumatoid arthritis (RA) and controls who were matched in age and sex. Patient data were collected from the National Health Insurance Service (NHIS) Health Screening (HEALS) cohort. Using the International Classification of Diseases code M05 (seropositive RA), with a prescription of any disease-modifying anti-rheumatic drug (DMARD), RA was identified. Read More

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Failure in Lumbar Spinal Fusion and Current Management Modalities.

Semin Plast Surg 2021 Feb 10;35(1):54-62. Epub 2021 May 10.

Department of Orthopaedic Surgery, Baylor College of Medicine, Houston, Texas.

Lumbar spinal fusion is a commonly performed procedure to stabilize the spine, and the frequency with which this operation is performed is increasing. Multiple factors are involved in achieving successful arthrodesis. Systemic factors include patient medical comorbidities-such as rheumatoid arthritis and osteoporosis-and smoking status. Read More

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February 2021

Patients' safety skills assessment with biologics and JAK inhibitors: update of the BioSecure questionnaire.

Joint Bone Spine 2021 May 13:105215. Epub 2021 May 13.

Service de Rhumatologie, Pitié-Salpêtrière Hospital, APHP. Sorbonne Université, Paris, France; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.

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Encephalomyelitis associated with rheumatoid arthritis: a case report.

Folia Neuropathol 2021 ;59(1):91-97

Department of Neurology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland.

Encephalitis/encephalomyelitis in the course of rheumatoid arthritis (RA) remains a matter of debate. We present a case of a patient with encephalomyelitis associated with RA confirmed with post-mortem neuropathological examination. A 68-year-old woman with a long-standing, seropositive history of RA presented progressive disturbances of consciousness. Read More

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January 2021

Gamabufotalin Inhibits Osteoclastgenesis and Counteracts Estrogen-Deficient Bone Loss in Mice by Suppressing RANKL-Induced NF-κB and ERK/MAPK Pathways.

Front Pharmacol 2021 23;12:629968. Epub 2021 Apr 23.

Department of Spine Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.

Osteolytic bone disease is a condition of imbalanced bone homeostasis, characterized mainly by excessive bone-resorptive activity, which could predispose these populations, such as the old and postmenopausal women, to developing high risk of skeletal fragility and fracture. The nature of bone homeostasis is the coordination between the osteoblasts (OBs) and osteoclasts (OCs). Abnormal activation of osteoclasts (OCs) could compromise the bone homeostasis, constantly followed by a clutch of osteolytic diseases, including postmenopausal osteoporosis, osteoarthritis, and rheumatoid arthritis. Read More

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2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis.

Ann Rheum Dis 2021 May 7. Epub 2021 May 7.

National Rheumatoid Arthritis Society, Littlewick Green, UK.

Background: An important but often insufficient aspect of care in people with inflammatory arthritis (IA) is empowering patients to acquire a good understanding of their disease and building their ability to deal effectively with the practical, physical and psychological impacts of it. Self-management skills can be helpful in this regard.

Objectives: To develop recommendations for the implementation of self-management strategies in IA. Read More

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Quality Indicators for Evaluating the Health Care of Patients with Rheumatoid Arthritis: a Korean Expert Consensus.

J Korean Med Sci 2021 May 3;36(17):e109. Epub 2021 May 3.

Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Background: There is increasing interest in the quality of health care and considerable efforts are being made to improve it. Rheumatoid arthritis (RA) is a disease that can result in favorable outcomes when appropriate diagnosis and treatment are provided. However, several studies have shown that RA is often managed inappropriately. Read More

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Risk factors associated with cervical spine lesions in patients with rheumatoid arthritis: an observational study.

BMC Musculoskelet Disord 2021 May 3;22(1):408. Epub 2021 May 3.

Departments of Orthopaedic Surgery, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan.

Background: Few reports have described the association between rheumatoid arthritis (RA) cervical lesions and osteoporosis, especially in patients with vertical subluxation (VS) that could be induced by the collapse of lateral masses in the upper cervical spine. Therefore, this study aimed to investigate the prevalence and risk factors for cervical lesions in patients with RA under current pharmacological treatments with biological agents, and to investigate the relationship between osteoporosis and VS development.

Methods: One hundred eighty-five consecutive patients with RA who underwent both cervical plain radiography and bone mineral density (BMD) scanning were enrolled. Read More

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Rheumatoid arthritis and depression.

Joint Bone Spine 2021 Apr 28;88(5):105200. Epub 2021 Apr 28.

Rheumatology department, University Hospital of Saint Etienne, Saint Etienne, France; Inserm U1059, Equipe LBTO, Université de Lyon, Saint-Étienne, France. Electronic address:

Depression constitutes the most frequent comorbid condition associated with rheumatoid arthritis (RA), with prevalence rates ranging from 14% to 48%. This wide range can be explained by several factors including subtypes of depression considered, instrument of measure (i.e. Read More

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Comparative effectiveness of two adalimumab biosimilars in 1318 real-world patients with inflammatory rheumatic disease mandated to switch from originator adalimumab: nationwide observational study emulating a randomised clinical trial.

Ann Rheum Dis 2021 Apr 29. Epub 2021 Apr 29.

DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen, Denmark.

Objectives: In 2018, a nationwide mandatory switch from originator to biosimilar adalimumab was conducted in Denmark. The available biosimilar was GP2017 (Hyrimoz) in Eastern regions and SB5 (Imraldi) in Western regions. We aimed to assess the comparative effectiveness of GP2017 versus SB5 in patients with rheumatoid arthritis (RA)/psoriatic arthritis (PsA)/axial spondyloarthritis (AxSpA). Read More

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Answer to Alunno et al. "Different clinical presentations of primary Sjögren's syndrome: Not only a matter of age". Joint Bone Spine 2021;88:105191.

Joint Bone Spine 2021 07 26;88(4):105199. Epub 2021 Apr 26.

Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, 59, Daesagwan-ro, Yongsan-gu, 04401 Seoul, South Korea.

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Craniocervical instability associated with rheumatoid arthritis: a case report and brief review.

AME Case Rep 2021 25;5:12. Epub 2021 Apr 25.

School of Nursing and Health Studies, The Open University of Hong Kong, Hong Kong, China.

Rheumatoid arthritis (RA) is an autoimmune disease that affects the synovial tissue which lines joints and tendons. The craniocervical junction is made up exclusively of synovial joints and ligaments and especially vulnerable to the inflammatory process of RA. The chronic inflammation of RA leads to loss of ligamentous restriction and erosion of the bony structures and results in craniocervical instability (CCI). Read More

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Facilitators and barriers in diagnosing rheumatoid arthritis as described by general practitioners: a Danish study based on focus group interviews.

Scand J Prim Health Care 2021 Apr 27:1-8. Epub 2021 Apr 27.

Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.

Objective: To explore the perspectives of general practitioners (GPs) on facilitators and barriers in diagnosing rheumatoid arthritis (RA).

Design: Qualitative study based on focus group interviews, and using latent thematic analysis.

Setting: General practices from Central Region Denmark. Read More

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Degenerative Adult Cervical Kyphosis With Secondary Diagnosis Codes Are Associated With Higher Cost and Complications After Spinal Fusion: A Medicare Database Study.

Int J Spine Surg 2021 Feb 12;15(1):26-36. Epub 2021 Feb 12.

The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Adult cervical deformity (ACD) is a potentially debilitating condition resulting from kyphosis, scoliosis, or both, of the cervical spine. Conditions such as ankylosing spondylitis, rheumatoid arthritis, Parkinson's disease, and neuromuscular diseases are particularly known to cause severe deformities. We describe the 90-day cost and complications associated with spinal fusion for ACD using International Classification of Diseases (ICD) coding terminology and study if secondary diagnoses associated with potential for severe deformity affect the cost and complication profile of ACD surgery. Read More

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February 2021

Comment on "Rheumatic presentations of Guillain-Barre syndrome as a diagnostic challenge: A case series" by Demuth et al. Joint Bone Spine 2021;88:105144.

Joint Bone Spine 2021 07 20;88(4):105190. Epub 2021 Apr 20.

Department of rheumatology, CHU Grenoble Alpes, Échirolles, France; GREPI TIMC, CNRS UMR 5525, université Grenoble Alpes, Grenoble, France.

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Recommendations for the pragmatic use of ultrasound in rheumatoid arthritis by the GEISPER French group.

Joint Bone Spine 2021 Jul 20;88(4):105187. Epub 2021 Apr 20.

Ambroise Paré Hospital, AP-HP, Université Versailles-Saint-Quentin en Yvelines - Rheumatology, Boulogne-Billancourt, France. Electronic address:

Objective: To develop recommendations for the appropriate use of ultrasound in the management of rheumatoid arthritis (RA) in routine practice based on data from the literature and of experts opinion.

Methods: Based on a systematic literature review, a scientific committee decided on themes and relevant questions to draw up an initial draft of recommendations. These recommendations were submitted to a group of experts in ultrasound in rheumatic and musculoskeletal diseases using a Delphi method, which produced preliminary recommendations. Read More

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A Novel Fluorescence Optical Imaging Scoring System for Hand Synovitis in Rheumatoid Arthritis - validity and agreement with ultrasound.

Rheumatology (Oxford) 2021 Apr 23. Epub 2021 Apr 23.

Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark.

Objectives: To develop and validate a new semiquantitative Fluorescence Optical Imaging (FOI) scoring system - the FOI Enhancement-Generated rheumatoid arthritis (RA) Score (FOIE-GRAS) for synovitis assessment in the hand.

Methods: The development of FOIE-GRAS was based on consensus of 4 experts in musculoskeletal imaging. Forty-six RA patients, eligible for treatment intensification and with ≥1 clinically swollen joint in the hands and 11 healthy controls were included. Read More

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The arthritis connection to inflammatory bowel disease (IBD): why has it taken so long to understand it?

RMD Open 2021 04;7(1)

Internal Medicine, Stanford University School of Medicine, Stanford, California, USA

Inflammatory bowel disease (IBD) associated arthritis is a subgroup of spondyloarthritis (SpA) that has suffered from lack of recognition in rheumatology clinical and research circles for over 100 years. Although clinically distinguishable from rheumatoid arthritis and ankylosing spondylitis, it took advances in detection systems in the middle of the last century (rheumatoid factor, HLA-B27) to convincingly make the final separations. We now know that significant numbers of patients with SpA have associated clinical IBD and almost half of them show subclinical gut inflammation, yet the connection between the gut and the musculoskeletal system has remained a vexing problem. Read More

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