3,676 results match your criteria Rheumatoid Arthritis Spine


Radiological and clinical comparisons of the patients with rheumatoid arthritis operated with rigid and dynamic instrumentation systems due to lumbar degenerative spinal diseases.

J Orthop Sci 2020 Jun 26. Epub 2020 Jun 26.

Okan University, Department of Neurosurgery, Istanbul, Turkey.

Background: It is extremely difficult to treat spine disorders with stabilization in patients with rheumatoid arthritis. Because revision rates are significantly higher in rigid stabilization. To date, there is no data about patients with rheumatoid arthritis treated with dynamic stabilization. Read More

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http://dx.doi.org/10.1016/j.jos.2020.05.011DOI Listing

[Frequency of sarcopenia and factors associated with lean mass in women with rheumatoid arthritis].

Ter Arkh 2020 Jun 5;92(5):15-21. Epub 2020 Jun 5.

Nasonova Research Institute of Rheumatology.

Aim: To evaluate the frequency of sarcopenia (SP) according to EWGSOP2 criteria and factors associated with low lean mass in women with rheumatoid arthritis (RA).

Materials And Methods: 79 women (aged 4075 years) with RA were enrolled in the study. We analyzed clinical data: age, body mass index (BMI), disease duration, methotrexate use, glucocorticoid use, anthropometric measurements, C-reactive protein level, disease activity score in 28 joints-erythrocyte sedimentation rate, bone mineral density (BMD) of the lumbar spine, femur neck, total hip and body composition by Dual energy X-ray absorptiometry. Read More

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http://dx.doi.org/10.26442/00403660.2020.05.000622DOI Listing

Rheumatoid arthritis risk in periodontitis patients: A systematic review and meta-analysis.

Joint Bone Spine 2020 Jun 25. Epub 2020 Jun 25.

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, P. R. China. Electronic address:

Objective: Many clinical studies have been carried out to investigate the relationship between periodontitis and rheumatoid arthritis (RA). Owing to limited evidence and inconsistent findings among these studies, it is unclear whether periodontitis would increase the risk for RA. This meta-analysis was performed to evaluate whether periodontitis represents a risk factor for RA. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.04.024DOI Listing

Deep surgical site infection after posterior instrumented fusion for rheumatoid upper cervical subluxation treated with antibiotic-loaded bone cement: Three case reports.

Medicine (Baltimore) 2020 Jun;99(26):e20892

Department of Orthopaedic Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.

Introduction: Patients with rheumatoid arthritis (RA) tend to be immunosuppressed due to RA itself and the therapeutic drugs administered. The management of surgical site infection (SSI) following upper cervical spinal instrumented fusion in RA patients is challenging; however, literature on the treatment for such conditions is scarce. We report 3 consecutive patients with RA, who developed deep SSI following upper cervical posterior fusion and were treated using antibiotic-loaded bone cement (ALBC). Read More

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http://dx.doi.org/10.1097/MD.0000000000020892DOI Listing

Protective effect of Ganoderic acid A on adjuvant-induced arthritis.

Immunol Lett 2020 Jun 18. Epub 2020 Jun 18.

Spine Surgery, Jingmen No. 2 People's Hospital, Jingchu University of Technology Affiliated Central Hospital, Jingmen, 448000, China. Electronic address:

The purpose of the experiment was to study the effect of Ganoderic acid A (GAA) on adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid arthritis (CIA) was established with type II collagen plus Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, synovial cell apoptosis, related cytokines and JAK3/STAT3 and nuclear factor-κB (NF-κB) signaling pathway were measured in rats. Read More

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http://dx.doi.org/10.1016/j.imlet.2020.06.010DOI Listing

Higher serum uric acid levels are associated with reduced risk of hip osteoporosis in postmenopausal women with rheumatoid arthritis.

Medicine (Baltimore) 2020 Jun;99(24):e20633

Divsion of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine.

Although the positive correlation between serum uric acid (UA) levels and bone mineral density (BMD) has been reported in the general population, there are little data regarding the effect of serum UA levels on bone loss in patients with rheumatoid arthritis (RA).We investigated whether increased serum UA levels were associated with a reduced risk of osteoporosis in postmenopausal women with RA.In this retrospective cross-sectional study, 447 postmenopausal female patients with RA and 200 age-matched, postmenopausal healthy controls underwent BMD examination by dual energy x-ray absorptiometry and serum UA levels measurement. Read More

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http://dx.doi.org/10.1097/MD.0000000000020633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302629PMC

Whole-Body MRI in Psoriatic Arthritis, Rheumatoid Arthritis And Healthy Controls - Interscan, Intrareader and Interreader Agreement and Distribution of Lesions.

J Rheumatol 2020 Jun 15. Epub 2020 Jun 15.

From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Diagnostic Imaging, Sheba Medical Center, affiliated to the Sacker School of Medicine, Tel Aviv University, Israel; Department of Rheumatology, Skaraborg Hospital, Skövde, Sweden; Department of Radiology, Herlev-Gentofte Hospital, Herlev, Denmark. Corresponding author: Anna Poulsen, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Nordre Ringvej 57, DK-2600 Glostrup, Denmark, telephone +4528738113, email:

Objective: Whole-body MRI (WBMRI) is promising for monitoring patients' global disease activity in inflammatory joint diseases. The validation of WBMRI is limited; no studies have evaluated the test-retest agreement (interscan agreement) and only few have assessed the intra- and interreader agreement. Therefore we examined the interscan agreement of WBMRI in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA) and healthy controls (HC); and secondly evaluated the intraand interreader agreement and agreement with conventional hand MRI and determined the distribution of lesions. Read More

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http://dx.doi.org/10.3899/jrheum.200084DOI Listing

Experience of pain is correlated to treatment profile in patients with rheumatoid arthritis. Differentiating 5 clusters of patients in a national cohort of 1100 women with rheumatoid arthritis.

Joint Bone Spine 2020 Jun 10. Epub 2020 Jun 10.

Centre d'Évaluation et Traitement de la Douleur, Hôpital Cochin, Université Paris Descartes, 75014 Paris, France; INSERM U987, 92100 Boulogne Billancourt, France.

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http://dx.doi.org/10.1016/j.jbspin.2020.05.012DOI Listing

Janus kinases inhibitors for treating patients with rhupus.

Joint Bone Spine 2020 Jun 10. Epub 2020 Jun 10.

Sapienza Università di Roma, Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Italy.

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http://dx.doi.org/10.1016/j.jbspin.2020.05.010DOI Listing

Predictors of disease flare after discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab.

Joint Bone Spine 2020 Jun 10. Epub 2020 Jun 10.

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan. Electronic address:

Objective: To investigate predictors of disease flare after methotrexate discontinuation in Japanese rheumatoid arthritis (RA) patients with sustained low disease activity undergoing tocilizumab plus methotrexate combination therapy.

Methods: Participants of this multicenter, open-label, uncontrolled, prospective study were RA patients maintaining low disease activity (Clinical Disease Activity Index [CDAI]≤10) for≥12weeks with tocilizumab plus methotrexate. Methotrexate was discontinued after 12weeks of biweekly administration while continuing tocilizumab therapy. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.06.001DOI Listing

Appropriateness of laboratory tests in the diagnosis of inflammatory rheumatic diseases among patients newly referred to rheumatologists.

Joint Bone Spine 2020 Jun 6. Epub 2020 Jun 6.

Department of Medicine, Western University, London, ON, Canada; Division or Rheumatology, Saint Joseph's Health Care, London, ON, Canada. Electronic address:

Introduction: Autoantibody tests are commonly ordered when screening for rheumatic diseases. Rheumatoid factor (RF) and antinuclear antibody (ANA) have low positive predictive values in general practice. Overuse of diagnostic tests can result in an increase in unnecessary referrals, patient anxiety, and further costs. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.05.007DOI Listing

Changes in bone mineral density over 10 years in patients with early rheumatoid arthritis.

RMD Open 2020 Feb;6(1)

Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.

Objectives: To investigate changes in bone mineral density (BMD) in patients with early rheumatoid arthritis (RA) over a 10-year period.

Methods: Consecutive patients with early RA (symptom duration <12 months) were followed according to a structured programme and examined with dual-energy X-ray absorptiometry (DXA) at inclusion and after 2, 5 and 10 years. Mean Z-scores over the study period were estimated using mixed linear effect models. Read More

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http://dx.doi.org/10.1136/rmdopen-2019-001142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046965PMC
February 2020

Immunoglobulin G4-related spinal pachymeningitis.

Authors:
Mousa N Alrashdi

Saudi Med J 2020 Jun;41(6):652-656

Department of Medicine, Collage of Medicine, Qassim University, Al Qassim, Kingdom of Saudi Arabia. E-mail.

Immunoglobulin G4-related disease (IgG4-RD) is rare disease entity and has recently been recognized as an inflammatory disorder with the tendency to affect multiple organs. Pachymeningitis of spine caused by IgG4-related disease is extremely rare. Neck pain and spinal cord compression symptoms consist of usual presentation of IgG4-related spinal pachymeningitis; however, polyarthritis is an unusual presentation of this disease, and it was reported in only one case that mimicked psoriatic arthritis. Read More

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http://dx.doi.org/10.15537/smj.2020.6.25086DOI Listing

Identification of Novel Native Autoantigens in Rheumatoid Arthritis.

Biomedicines 2020 May 29;8(6). Epub 2020 May 29.

Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.

The majority of patients diagnosed with rheumatoid arthritis (RA) have developed autoantibodies against neoepitopes in proteins that have undergone post-translational modification, e.g., citrullination or carbamylation. Read More

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http://dx.doi.org/10.3390/biomedicines8060141DOI Listing

Preferences for Self-Management and Support Services in Patients with Inflammatory Joint Disease - A Danish Nationwide Cross-Sectional Study.

Arthritis Care Res (Hoboken) 2020 May 31. Epub 2020 May 31.

Copenhagen Center for Arthritis Research, Centre for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.

Objective: To explore preferences for self-management and support services in patients with inflammatory joint disease (IJD) and whether these preferences differ by age, gender, diagnosis and disease duration.

Methods: Nationwide cross-sectional online survey for patients with rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. Descriptive statistics were applied to explore preferences and test for differences according to the different subgroups of patients. Read More

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http://dx.doi.org/10.1002/acr.24344DOI Listing
May 2020
4.713 Impact Factor

Metabolomics in the development and progression of rheumatoid arthritis: A systematic review.

Joint Bone Spine 2020 May 27. Epub 2020 May 27.

School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China. Electronic address:

Objective: A systematic review and analysis of data from several rheumatoid arthritis metabolomics studies attempts to determine which metabolites can be used as potential biomarkers for the diagnosis of rheumatoid arthritis and to explore the pathogenesis of rheumatoid arthritis.

Methods: We searched all the subject-related documents published by EMBASE, PubMed, Web of Science, and Cochrane Library from the database to the September 2019 publication. Two researchers independently screened the literature and extracted the data. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.05.005DOI Listing

Cognitive behavioural therapy for insomnia in patients with rheumatoid arthritis: protocol for the randomised, single-blinded, parallel-group Sleep-RA trial.

Trials 2020 May 29;21(1):440. Epub 2020 May 29.

Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark.

Background: More than half of patients with rheumatoid arthritis complain of insomnia, which is predominantly treated with hypnotic drugs. However, cognitive behavioural therapy for insomnia is recommended as the first-line treatment in international guidelines on sleep. Patients with rheumatoid arthritis suffer from debilitating symptoms, such as fatigue and pain, which can also be linked to sleep disturbance. Read More

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http://dx.doi.org/10.1186/s13063-020-04282-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257190PMC

Panniculitis following baricitinib initiation for treatment of rheumatoid arthritis.

Joint Bone Spine 2020 May 4. Epub 2020 May 4.

Clinical Trials and Outcomes Branch, Intramural Research Program, National Institutes of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, 10 Center Drive Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1016/j.jbspin.2020.04.002DOI Listing

Prevalence of COVID-19 among patients with chronic inflammatory rheumatic diseases treated with biologic agents or small molecules: A population-based study in the first two months of COVID-19 outbreak in Italy.

Joint Bone Spine 2020 May 20. Epub 2020 May 20.

Clinic of Rheumatology, Department of Medicine (DAME), ASUFC, University of Udine, Udine, Italy.

Objective: The aim of this study is to determine the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) among adult patients treated with biologic agents or small molecules for chronic inflammatory rheumatic diseases, in particular for chronic inflammatory arthritides.

Methods: To this end, a population-based study, in the province of Udine (466,700 inhabitants, with age>15 years old, Friuli Venezia Giulia region, Italy) was planned. The primary outcome was the prevalence of COVID-19 in the first two months of the outbreak. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239017PMC

Impact of persistence with tumour necrosis factor inhibitors on healthcare resource utilization and costs in chronic inflammatory joint diseases.

Br J Clin Pharmacol 2020 May 22. Epub 2020 May 22.

GRC 08, Institut Pierre Louis d'Epidémiologie et Santé Publique, AP-HP, Service de Rhumatologie, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France.

Aim: To assess persistence with subcutaneous (SC) tumour necrosis factor (TNF) inhibitors as well as the impact of persistence on healthcare resource utilization (HCRU) and costs in patients with chronic inflammatory joint diseases.

Methods: In this cohort study using population-based French claims data (from 2011 to 2014), we measured persistence with SC TNF inhibitors within 12 months (M0-12) following treatment initiation in treatment-naïve and treatment-experienced users (divided into three cohorts: rheumatoid arthritis [RA], ankylosing spondylitis [AS] and psoriatic arthritis [PsA]). Persistent patients were propensity score matched to nonpersistent patients at M12. Read More

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http://dx.doi.org/10.1111/bcp.14387DOI Listing

Head-to-head trials in inflammatory arthritis.

Joint Bone Spine 2020 May 11. Epub 2020 May 11.

Rheumatology department, CHU Montpellier, Montpellier University, Montpellier, France.

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http://dx.doi.org/10.1016/j.jbspin.2020.04.015DOI Listing

Sex hormone-binding globulin and arthritis: a Mendelian randomization study.

Arthritis Res Ther 2020 05 18;22(1):118. Epub 2020 May 18.

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, 310009, Hangzhou, China.

Background: Sex hormone-binding globulin (SHBG) has been reported to be a risk factor associated with the development of arthritis by previous observational studies more so of three common forms of arthritis: osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). This study aimed to determine whether the concentrations of circulating SHBG are causally associated with the risk of OA, RA, and AS.

Methods: The two-sample Mendelian randomization (MR) approach was used for this study. Read More

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http://dx.doi.org/10.1186/s13075-020-02202-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236473PMC

The necessity and risk factors of subsequent fusion after decompression alone for lumbar spinal stenosis with lumbar spondylolisthesis: 5 years follow-up in two different large populations.

Spine J 2020 May 15. Epub 2020 May 15.

Hospital for Special Surgery, 535 E. 70th St, New York, NY 10021, USA; Weill Cornell Medical College, New York, NY, USA. Electronic address:

Background/context: Although decompression without fusion is a reasonable surgical treatment option for some patients with lumbar spinal stenosis (LSS) secondary to spondylolisthesis, some of these patients will require secondary surgery for subsequent fusion. Long-term outcome and need for subsequent fusion in patients treated with decompression alone in the setting of lumbar spondylolisthesis remains controversial.

Purpose: The aim of this study was to examine the rate, timing, and risk factors of subsequent fusion for patients after decompression alone for LSS with spondylolisthesis. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.04.026DOI Listing

Radiological Findings of the Cervical Spine in Rheumatoid Arthritis: What a Rheumatologist Should Know.

Curr Rheumatol Rep 2020 May 13;22(6):19. Epub 2020 May 13.

Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Ioannina, Greece.

Purpose Of Review: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting mainly the peripheral skeleton in a symmetrical manner rather than the axial skeleton, but when it occurs it can affect the cervical spine (CS). Although CS involvement is a frequent radiographic finding in RA, the clinical features are scarce, but potentially life-threatening with severe neurological deficits or even death due to brain stem compression. The commonest site of inflammation of the CS is the articulation between C and C vertebrae, the atlanto-axial region. Read More

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http://dx.doi.org/10.1007/s11926-020-00894-8DOI Listing
May 2020
2.454 Impact Factor

Early discontinuation of tofacitinib in patients with rheumatoid arthritis co-treated with rifampin for latent tuberculosis.

Joint Bone Spine 2020 May 7. Epub 2020 May 7.

Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, 05505 Seoul, Korea. Electronic address:

Objective: Rifampin is known to influence the pharmacokinetics of tofacitinib owing to drug interactions. The aim of this study was to determine the efficacy of tofacitinib on co-administration with rifampin in rheumatoid arthritis (RA) patients.

Methods: Biologic-naïve RA patients treated with tofacitinib were selected, and electronic medical reports were reviewed retrospectively. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.04.010DOI Listing

Implementation of comorbidities' systematic screening program in daily practice in France.

Joint Bone Spine 2020 May 6. Epub 2020 May 6.

Department of Rheumatology, Grenoble Alpes University Hospital, 38130 Grenoble, France; TIMC-IMAG UMR CNRS 5525, Grenoble Alpes University, Grenoble, France.

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http://dx.doi.org/10.1016/j.jbspin.2020.04.011DOI Listing

Agreement with the French 2019 recommendations on treatment adherence in rheumatic diseases among 357 health professionals.

Joint Bone Spine 2020 May 5. Epub 2020 May 5.

Rheumatology Department, Cochin Hospital, AP-HP, Centre, 75014 Paris, France; Inserm Unit 1153, Université de Paris, PRES Sorbonne Paris-Cité, 75014 Paris, France.

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http://dx.doi.org/10.1016/j.jbspin.2020.04.008DOI Listing

Cortical thickness relative to the transverse diameter of third metacarpal bone reflects bone mineral density in patients with rheumatoid arthritis.

Bone 2020 May 3;137:115405. Epub 2020 May 3.

Department of Radiology, Yoshii Hospital, 6-7-5 Nakamura-Ohashidori, Shimanto-City 787-0033, Kochi, Japan.

Objective: Rheumatoid arthritis (RA) is accompanied by potential risk of bone mineral loss. In this study, we developed a screening index for the osteoporosis related level of bone mineral density loss for RA patients as a substitute to the dual-energy X-ray absorptiometry (DXA) method.

Methods: X-ray pictures of both sides of the hand were taken in order to evaluate Sharp/van der Heijde Scores (SHSs). Read More

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http://dx.doi.org/10.1016/j.bone.2020.115405DOI Listing

Risk factors associated with fatigue in patients with rheumatoid arthritis.

Joint Bone Spine 2020 Mar 26. Epub 2020 Mar 26.

Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2020.03.004DOI Listing

Impact of season on the association between vitamin D levels at diagnosis and one-year remission in early Rheumatoid Arthritis.

Sci Rep 2020 Apr 30;10(1):7371. Epub 2020 Apr 30.

Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark.

The study evaluates associations between serum vitamin D metabolites at diagnosis and one-year remission, in early diagnosed rheumatoid arthritis(RA). The CIMESTRA-cohort comprised 160 newly diagnosed RA patients, treated aiming at remission. Vitamin D supplementation was recommended according to national guidelines. Read More

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http://dx.doi.org/10.1038/s41598-020-64284-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192905PMC

Pathogenesis of Axial Spondyloarthritis - Sources and Current State of Knowledge.

Authors:
Joerg Ermann

Rheum Dis Clin North Am 2020 May;46(2):193-206

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, HBTM, Room 06002P, 60 Fenwood Road, Boston, MA 02115, USA. Electronic address:

Scientific breakthroughs have culminated in the development of the spondyloarthritis (SpA) concept as a family of rheumatic diseases, distinct from rheumatoid arthritis. The demonstration of inflammatory lesions in the sacroiliac joints and spine of patients with axial symptoms of SpA who lacked radiographic features of ankylosing spondylitis (AS) helped refine the SpA concept. Axial SpA includes patients with AS and patients with axial symptoms previously categorized as undifferentiated SpA. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.01.016DOI Listing

Cervical Pannus Without Rheumatoid Arthritis or Trauma.

Fed Pract 2020 Apr;37(4):194-197

is Chair, Internal Medicine and an Associate Professor of Neurology; and is a Medical Student, both at Liberty University College of Osteopathic Medicine in Lynchburg, Virginia.

Although usually seen in patients with rheumatoid arthritis, cervical pannus also can develop in patients who have had spine surgery. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173635PMC

Occipital Plate Fixation in the Pediatric Population.

J Pediatr Orthop 2020 Apr 14. Epub 2020 Apr 14.

Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, MA.

Background: Occipital plate fixation has been shown to improve outcomes in cervical spine fusion. There is a paucity of literature describing occipital plate fixation, especially in the pediatric population. The authors reviewed a case series of 34 patients at a pediatric hospital who underwent cervical spine fusion with occipital plate fixation between 2003 and 2016. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001564DOI Listing

Obesity potentially protects against systemic bone loss in patients with rheumatoid arthritis treated with tumour necrosis factor inhibitors.

Clin Exp Rheumatol 2020 Apr 9. Epub 2020 Apr 9.

Division of Rheumatology, College of Medicine, Inha University, Incheon, Republic of Korea.

Objectives: We aimed to investigate how systemic bone metabolism was affected after 1 year of treatment with tumour necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients.

Methods: A total of 29 seropositive RA patients not treated for osteoporosis were enrolled and TNF inhibitors were administered for a year. Bone mineral density (BMD) at the lumbar spine, femur neck, and total hip was measured at baseline and 12 months after anti-TNF treatment. Read More

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Effects of glucocorticoids on osteoporosis in rheumatoid arthritis: a systematic review and meta-analysis.

Osteoporos Int 2020 Apr 14. Epub 2020 Apr 14.

Department of Gastroenterology, Affiliated Hospital of Nantong University, 20th Xisi Road, Nantong, 226001, Jiangsu Province, People's Republic of China.

We evaluated the effects of glucocorticoids on bone mineral density (BMD), and prevalence of osteoporosis and fracture in rheumatoid arthritis (RA) by meta-analysis. Until June 26, 2019, we conducted a systematic literature search in EMBASE, Web of science, PubMed, and Cochrane Library to obtain BMD and the prevalence of osteoporosis and fracture in glucocorticoid-treated subjects with RA. The BMD of the treatment and control groups were analyzed by meta-analysis (Stata. Read More

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http://dx.doi.org/10.1007/s00198-020-05360-wDOI Listing

Basal metabolic rate and Charlson Comorbidity Index are independent predictors of metabolic syndrome in patients with rheumatoid arthritis.

Joint Bone Spine 2020 Apr 9. Epub 2020 Apr 9.

Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School & Hospital, 42 Jebong-ro, Dong-gu, Gwangju 61469, Republic of Korea. Electronic address:

Objective: To prospectively analyze predictors of metabolic syndrome (MetS) in patients with rheumatoid arthritis (RA) during 2years of follow-up.

Methods: We recruited 319 consecutive patients with RA who did not have MetS. MetS was defined in accordance with the modified National Cholesterol Education Program/Adult Treatment Panel III 2005 for Asian populations. Read More

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http://dx.doi.org/10.1016/j.jbspin.2020.03.015DOI Listing

Serum zinc levels and multiple health outcomes: Implications for zinc-based biomaterials.

Bioact Mater 2020 Jun 31;5(2):410-422. Epub 2020 Mar 31.

Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.

Background: Zinc-based biomaterials, including biodegradable metal, nanoparticles, and coatings used in medical implants release zinc ions that may increase the whole-body and serum zinc concentrations. The impact of serum zinc concentrations on major health outcomes can provide insights for device design and clinical transformation of zinc-based biomaterials.

Methods: This nationally representative cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey (NHANES, 2011-2014) including 3607 participants. Read More

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http://dx.doi.org/10.1016/j.bioactmat.2020.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114479PMC

Correction to: Assessment of cervical spine involvement in rheumatoid arthritis patients in the era of biologics: a real-life, cross-sectional MRI study.

Rheumatol Int 2020 Jun;40(6):923

Division of Rheumatology, Faculty of Medicine, University of Debrecen, Nagyerdei str 98, Debrecen, 4032, Hungary.

In the original article, the first author's given name and family name were interchanged as provided by the authors in the original manuscript. Read More

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http://dx.doi.org/10.1007/s00296-020-04572-xDOI Listing

Knee or Spine Surgery First? A Survey of Treatment Order for Patients With Concurrent Degenerative Knee and Lumbar Spinal Disorders.

J Arthroplasty 2020 Mar 14. Epub 2020 Mar 14.

Department of Orthopaedic Surgery, Stanford University, Redwood City, California.

Background: Total knee arthroplasty (TKA) and lumbar spine surgery have been reported to affect the outcomes of each other. There is insufficient evidence to guide the choice of treatment order for patients with both disorders that are equally symptomatic.

Methods: Five clinical scenarios of concurrent, advanced, degenerative knee and lumbar spinal disorders were designed to survey surgeons' choices of treatment order and rationale. Read More

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http://dx.doi.org/10.1016/j.arth.2020.03.018DOI Listing

Predictive factors of treatment persistence in rheumatoid arthritis.

Joint Bone Spine 2020 Mar 25. Epub 2020 Mar 25.

Division of Rheumatology, Geneva University Hospitals, 1206 Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.jbspin.2020.03.006DOI Listing

A Modified Posterior Approach for Decompression of a Multi-Loculated Atlanto-Axial Cyst With Myelopathy.

Spine (Phila Pa 1976) 2020 Mar 19. Epub 2020 Mar 19.

Department of Spine Surgery, Nanavati Super Specialty Hospital, Mumbai, Maharashtra, India.

Study Design: Case report.

Objective: To describe a modified posterior approach for decompression and excision of a multiloculated atlanto-axial cyst.

Summary Of Background Data: Atlanto-axial cyst with myelopathy is rare. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003499DOI Listing

Future use of musculoskeletal ultrasonography and magnetic resonance imaging in rheumatoid arthritis.

Curr Opin Rheumatol 2020 May;32(3):264-272

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet Glostrup, Glostrup.

Purpose Of Review: Musculoskeletal ultrasonography (MSUS) and magnetic resonance imaging (MRI) play important roles in diagnosis, monitoring, and prognostication of rheumatoid arthritis. This review highlights recent literature in this field and aims to provide insight into the future use in clinical practice.

Recent Findings: Recent studies concerning the use of MSUS and MRI in clinical practice show how MSUS and MRI can improve diagnosis and monitoring of rheumatoid arthritis and how they can predict both radiographic progression and clinical outcome (e. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000709DOI Listing

Cervical Myelopathy in Patients Suffering from Rheumatoid Arthritis-A Case Series of 9 Patients and A Review of the Literature.

J Clin Med 2020 Mar 17;9(3). Epub 2020 Mar 17.

Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany.

Cervical myelopathy occurs in approximately 2.5% of patients suffering from rheumatoid arthritis (RA) and is associated with notable morbidity and mortality. However, the surgical management of patients affected by cervical involvement in the setting of RA remains challenging and not well studied. Read More

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http://dx.doi.org/10.3390/jcm9030811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141180PMC

Assessment of cervical spine involvement in rheumatoid arthritis patients in the era of biologics: a real-life, cross-sectional MRI study.

Rheumatol Int 2020 Jun 16;40(6):915-921. Epub 2020 Mar 16.

Division of Rheumatology, Faculty of Medicine, University of Debrecen, Nagyerdei str 98, Debrecen, 4032, Hungary.

Cervical spine involvement may lead to severe complications in rheumatoid arthritis (RA). In the era of modern therapies, atlantoaxial subluxation (AAS) may be rare; however, it may still be detected in asymptomatic patients. The onset of myelopathy can occur at any time. Read More

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http://dx.doi.org/10.1007/s00296-020-04549-wDOI Listing

Miniplate-Augmented Interlaminar Fusion in C1-C2 Screwing.

World Neurosurg 2020 Jun 13;138:e634-e641. Epub 2020 Mar 13.

Department of Neurosurgery, Taipei Medical University, Taipei, Taiwan; Department of Surgery, Taipei Medical University, Taipei, Taiwan; Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan.

Objective: The interlaminar fusion combination involving C1-C2 screwing fixation is one of the most effective techniques for atlantoaxial dislocation or subluxation, and the bone graft is usually stabilized by wiring constructs. However, some adverse events were reported during the insertion of sublaminar wiring, such as accidentally damaging the spinal cord or dura. Thus we used the miniplate to stabilize the harvest bone graft on the C1-C2 laminar, which led to a shorter operation time and prevented spinal canal violation. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.023DOI Listing

[Evaluation of the trabecular bone score (TBS) in routine clinical care of patients with inflammatory rheumatic and non-inflammatory diseases : Correlation with conventional bone mineral density measurement and prevalence of vertebral fractures].

Z Rheumatol 2020 Mar 11. Epub 2020 Mar 11.

Rheumazentrum Ruhrgebiet, Ruhr Universität Bochum, Claudiusstr. 45, 44649, Herne, Deutschland.

Background: Osteoporosis-related fractures are common in patients with rheumatoid arthritis (RA). Bone mineral density (BMD) measurements using dual-energy x‑ray absorptiometry (DXA) alone has only a limited value for predicting the risk of fractures. The trabecular bone score (TBS) is a surrogate parameter for trabecular microarchitecture of bone and a predictor of fracture risk independent of BMD. Read More

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http://dx.doi.org/10.1007/s00393-020-00764-9DOI Listing

Risk of neuroinflammatory events in arthritis patients treated with tumour necrosis factor alpha inhibitors: a collaborative population-based cohort study from Denmark and Sweden.

Ann Rheum Dis 2020 05 11;79(5):566-572. Epub 2020 Mar 11.

Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark.

Objectives: To investigate whether tumour necrosis factor alpha inhibitors (TNFis) are associated with an increased risk of neuroinflammatory diseases among patients with arthritic diseases.

Methods: Cohorts of patients with rheumatoid arthritis (RA, n=25 796), psoriatic arthritis (PsA, n=8586) and ankylosing spondylitis (AS, n=9527) who initiated a TNFi treatment year 2000-2017 were identified from nationwide clinical rheumatology registers in Sweden and Denmark. Information on demyelinating disease and inflammatory neuropathy diagnoses was retrieved from prospective linkage to National Patients Register. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-216693DOI Listing

NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium.

Sci Rep 2020 Mar 9;10(1):4316. Epub 2020 Mar 9.

Genomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.

This study sought to evaluate the association of 28 single nucleotide polymorphisms (SNPs) within NFKB and inflammasome pathway genes with the risk of rheumatoid arthritis (RA) and response to TNF inhibitors (TNFi). We conducted a case-control study in a European population of 1194 RA patients and 1328 healthy controls. The association of potentially interesting markers was validated with data from the DANBIO (695 RA patients and 978 healthy controls) and DREAM (882 RA patients) registries. Read More

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http://dx.doi.org/10.1038/s41598-020-61331-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062729PMC
March 2020
5.078 Impact Factor