4,040 results match your criteria Rheumatoid Arthritis Spine


Risk of Spine Surgery in Patients with Rheumatoid Arthritis: A Secondary Cohort Analysis of a Nationwide, Population-Based Health Claim Database.

Medicina (Kaunas) 2022 Jun 8;58(6). Epub 2022 Jun 8.

Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin, Chiayi 62247, Taiwan.

: To study the risk of spine surgery, including cervical and lumbar spine surgeries in patients with rheumatoid arthritis (RA) compared with those without a diagnosis of RA. : This is a secondary data analysis using population-based health claim data. We identified newly diagnosed adult patients with RA between January 2000 and December 2012, according to the International Classification of Diseases, Ninth revision, clinical modification code 714. Read More

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Identification of Biomarkers Associated with Diagnosis of Osteoarthritis Patients Based on Bioinformatics and Machine Learning.

J Immunol Res 2022 13;2022:5600190. Epub 2022 Jun 13.

Spine Surgery, The Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.

Osteoarthritis (OA) is thought to be the most prevalent chronic joint disease. The incidence of OA is rising because of the ageing population and the epidemic of obesity. This research was designed for the identification of novel diagnostic biomarkers for OA and analyzing the possible association between critical genes and infiltrated immune cells. Read More

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Impact of continuity of care on risk for major osteoporotic fracture in patients with new onset rheumatoid arthritis.

Sci Rep 2022 Jun 17;12(1):10189. Epub 2022 Jun 17.

Department of Preventive Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

There is a clear relationship between rheumatoid arthritis (RA) and major osteoporotic fracture (MOF), although there is limited evidence on the effect of continuity of care (COC) on MOF in these patients. We investigated the association between COC and risk of MOF, including fractures of the lumbar spine and pelvis, forearm, and hip, among newly diagnosed RA patients aged ≥ 60 years. A total of 8715 incident RA patients from 2004 to 2010 were included from the Korean National Health Insurance Service-Senior cohort database. Read More

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Factors associated with low bone mineral density in postmenopausal women with rheumatoid arthritis.

J Pak Med Assoc 2022 May;72(5):891-895

Department of Rheumatology, Fauji Foundation Hospital, Rawalpindi, Pakistan.

Objective: To determine the factors related to low bone density in postmenopausal women with rheumatoid arthritis.

Methods: The prospective cross-sectional study was conducted at the Rheumatology Department of Fauji Foundation Hospital, Rawalpindi, Pakistan, from June 1 to November 30, 2020, and comprised postmenopausal women with rheumatoid arthritis. On the basis of dual-energy X-ray absorptiometry scan of total hip, femoral neck, and lumbar spine, the subjects were categorised into osteoporosis, osteopenia and normal bone density groups. Read More

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[Research on effectiveness of occipito-odontoid angle in predicting dysphagia after occipitocervical fusion in patients with C Klippel-Feil syndrome].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Jun;36(6):739-744

Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.

Objective: To introduce a new occipitocervical angle parameter, occipito-odontoid angle (O-Da), for predicting dysphagia after occipitocervical fusion (OCF) in patients with C Klippel-Feil syndrome (KFS) and analyze its effectiveness.

Methods: A total of 119 patients met selective criteria between April 2010 and November 2019 were retrospectively included as the study subjects. There were 56 males and 63 females. Read More

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Long-term behavioral changes during the COVID-19 pandemic and impact of vaccination in patients with inflammatory rheumatic diseases.

J Rheumatol 2022 Jun 15. Epub 2022 Jun 15.

DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, University Hospital of Copenhagen Rigshospitalet, Glostrup, Denmark, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Center for Rheumatology and Spine Diseases Gentofte and Herlev Hospital, Denmark; Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark Sønderborg, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Rheumatology, Zealand University Hospital, Køge, Denmark; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark; Diagnostic Center, Silkeborg Regional Hospital, Silkeborg, Denmark; Department of Medicine, Horsens Regional Hospital, Horsens, Denmark; Zitelab, Copenhagen, Denmark; Gigtforeningen/Danish Rheumatism Association, Denmark Competing Interests: Bente Glintborg: Research grants: AbbVie, BMS, Pfizer; Oliver Hendricks: Research Grants: AbbVie, Novartis, Pfizer; Lene Terslev: speakers fee: Speakers fee from Roche, Novartis, Pfizer, and UCB;Mikkel Østergaard: Research grants: Abbvie, BMS, Celgene, Merck, Novartis; Consultancy and/or speaker fees: Abbvie, BMS, Boehringer-Ingelheim, Celgene, Eli-Lilly, Galapagos, Gilead, Hospira, Janssen, Merck, Novartis, Novo, Orion, Pfizer, Regeneron, Roche, Sandoz, Sanofi and UCB. Rene Østgård: research grants: Abbvie; Consultancy and/or speaker fees: Abbvie, BMS, Boehringer-Ingelheim, Eli-Lilly, Janssen, Merck, Novartis, Pfizer, Roche, Sanofi and UCB. Anne Gitte Loft: consultancy and/or speakers fees: AbbVie, Eli-Lilly, Janssen, MSD, Novartis, Pfizer, and UCB Merete Lund Hetland: AbbVie, Biogen, BMS, Celtrion, Eli Lilly Denmark A/S, Janssen Biologics B.V, Lundbeck Fonden, MSD, Pfizer, Roche, Samsung Biopis, Sandoz. MLH chairs the steering committee of the Danish Rheumatology Quality Registry (DANBIO), which receives public funding from the hospital owners and funding from pharmaceutical companies. MLH co-chairs EuroSpA, which generates real-world evidence of treatment of psoriatic arthritis and axial spondylorthritis based on secondary data and is partly funded by Novartis. Funding: Partly funded by an unrestricted grant by The Lundbeck Foundation (grant-number R349-2020-629).

Objective: To explore anxiety and self-isolation 15 months into the COVID-19 pandemic including attitudes towards and impact of SARS-CoV-2 vaccination in patients with inflammatory rheumatic disease (IRD).

Methods: Nationwide online survey at three time points (May 2020, November 2020, May 2021). Patients with IRD followed in the Danish DANBIO registry were asked about the impact of the pandemic (SARS-CoV-2-infection, behavior, anxiety, concerns). Read More

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Bone Morphogenetic Protein in Anterior Lumbar Interbody Fusions: A Propensity-Matched Medicare Outcome Analysis.

Int J Spine Surg 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL, USA.

Background: Bone morphogenetic protein (BMP) is a costly agent commonly used in spine surgery. Its effectiveness and complication profile have never been studied in a large, propensity-matched population following its approval by the Food and Drug Administration for use in single-level anterior lumbar interbody fusion (ALIF) surgeries.

Objective: To investigate the rate of symptomatic pseudarthrosis or need for revision surgery after single-level stand-alone ALIFs with and without the use of BMP. Read More

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Comparison of Romosozumab Versus Denosumab Treatment on Bone Mineral Density After One Year in Rheumatoid Arthritis Patients with Severe Osteoporosis: A Randomized Clinical Pilot Study.

Mod Rheumatol 2022 Jun 11. Epub 2022 Jun 11.

Department of Orthopaedic Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Objectives: To investigate the effect of romosozumab versus denosumab treatment on bone mineral density (BMD), disease activity, and joint damage in patients with rheumatoid arthritis (RA) and severe osteoporosis.

Methods: Fifty-one postmenopausal women were enrolled and randomized equally into two groups to receive either romosozumab or the denosumab. Changes (Δ) in the BMD (at lumbar spine, total hip, and femoral neck), disease activity score in 28 joints (DAS28)-erythrocyte sedimentation rate (ESR), and van der Heijde-modified Total Sharp Score (TSS) from baseline to 12 months after treatment were evaluated. Read More

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Effect of sarcopenia and poor balance on vertebral spinal osteoporotic fracture in female rheumatoid arthritis.

Sci Rep 2022 Jun 8;12(1):9477. Epub 2022 Jun 8.

Department of Rheumatology and Nephrology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, 230000, China.

This study investigated the effect of poor balance and sarcopenia on vertebral spinal osteoporotic fracture (VOPF) in female rheumatoid arthritic (RA) patients. A total of 195 female RA and 126 normal subjects were enrolled, and the correlations between sarcopenia, poor balance and VOPF were analyzed. Furthermore, we explored the relationships between sarcopenia or poor balance with disease related indexes of female RA. Read More

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Multiple autoimmune disorders in a patient with neuromyelitis optica spectrum disorder presenting with rhabdomyolysis.

BMJ Case Rep 2022 Jun 7;15(6). Epub 2022 Jun 7.

Internal Medicine, PGIMER, Chandigarh, India

Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating disease of the central nervous system characterised by longitudinal extensive transverse myelitis and involvement of the optic nerve and is associated with many autoimmune disorders. The index case, a known case of Hashimoto's thyroiditis, presented with quadriparesis and tea-coloured urine. Investigations revealed ongoing rhabdomyolysis related to autoimmune myositis and autoimmune haemolytic anaemia leading to pigment-induced acute kidney injury. Read More

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Impact of Treat-to-Target Therapy on Bone Mineral Density Loss in Patients With Rheumatoid Arthritis: A Prospective Cohort Study.

Front Endocrinol (Lausanne) 2022 17;13:867610. Epub 2022 May 17.

Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China.

Background: Osteoporosis is a common comorbidity of rheumatoid arthritis (RA). Although RA disease activity has been demonstrated to be associated with bone loss in previous studies, most of them were cross-sectional studies and not in the context of treat-to-target (T2T) strategies.

Objectives: This study aimed to evaluate the association of disease activity with bone mineral density (BMD) changes in the context of T2T strategies in a prospective RA cohort. Read More

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Making space for patients' preferences in precision medicine: a qualitative study exploring perspectives of patients with rheumatoid arthritis.

BMJ Open 2022 Jun 1;12(6):e058303. Epub 2022 Jun 1.

Department of Clinical Medicine, University of Copenhagen, Kobenhavn, Denmark.

Objective: Precision medicine in rheumatoid arthritis (RA) creates new opportunities to involve patients in early identification of accurate indicators of health trajectories. The aim of this study was to explore patient perspectives on patient-centredness in precision medicine for RA treatment.

Design: Semistructured interviews were conducted to explore patients' perspectives on a new personalised approach to RA treatment. Read More

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Sustained DMARD-free remission in rheumatoid arthritis - about concepts and moving towards practice.

Joint Bone Spine 2022 May 27;89(6):105418. Epub 2022 May 27.

Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands; Department of Rheumatology, Erasmus Medical Centre, Rotterdam, The Netherlands.

Sustained DMARD-free remission (SDFR) is the best possible outcome in RA. It is characterized by sustained absence of clinical arthritis, which is accompanied by resolution of symptoms and restoration of normal physical functioning. Therefore it's the best proxy for cure in RA. Read More

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[CME Rheumatology 26: Rheumatological Cases].

Praxis (Bern 1994) 2022 ;111(7):421-427

Spinale Chirurgie, Universitätsspital Basel, Basel, Schweiz.

CME Rheumatology 26: Rheumatological Cases Special rheumatological cases are illustrated using various examples. On the one hand we present differential diagnoses and causes of a "Baker's cyst", on the other hand a case of involvement of the cervical spine in rheumatoid arthritis. Usually, the medical history and precise clinical examination will lead us in the right diagnostic direction. Read More

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Huangqi Guizhi Wuwu Decoction Improves Arthritis and Pathological Damage of Heart and Lung in TNF-Tg Mice.

Front Pharmacol 2022 4;13:871481. Epub 2022 May 4.

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Huangqi Guizhi Wuwu Decoction (HGWD) is a traditional and effective Chinese medicine compound decoction for the treatment of rheumatoid arthritis (RA). However, there is few research on the treatment of rheumatoid cardiopulmonary complications. The present study was to study whether HGWD can alleviate the pathological changes caused by rheumatoid arthritis and cardiopulmonary complications. Read More

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The emerging role of ultrasound in detecting interstitial lung disease in patients with rheumatoid arthritis.

Joint Bone Spine 2022 May 7;89(6):105407. Epub 2022 May 7.

Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación, Luis Guillermo Ibarra Ibarra, Calzada Mexico-Xochimilco 289, 143898 Colonia Arenal de Guadalupe, Mexico City, Mexico.

Objective: To investigate the potential role of US in the detection of ILD in a cohort of patients with RA.

Methods: Patients with diagnosis of RA were consecutively enrolled. All patients underwent pulmonary examination, laboratory data, DLCO measure, chest HRCT and radiographs, and US examination. Read More

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Time-averaged DAS28 and HAQ predict cardiovascular disease in patients with rheumatoid arthritis: Data from KORONA registry.

Joint Bone Spine 2022 May 2;89(5):105401. Epub 2022 May 2.

Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul Saint-Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Objective: To evaluate the predictive role of time-averaged disease activity score (DAS)28 and Health Assessment Questionnaire (HAQ) on cardiovascular disease (CVD) events in patients with rheumatoid arthritis (RA).

Methods: Patients with RA were recruited from 23 tertiary hospitals. Baseline and annual follow-up data of demographic, laboratory, questionnaire, RA-associated parameters, and occurrence of CVD were collected. Read More

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Roles of osteoclast-associated receptor in rheumatoid arthritis and osteoarthritis.

Joint Bone Spine 2022 Apr 30;89(5):105400. Epub 2022 Apr 30.

Department of Life Science, Ewha Womans University, Seoul 03760, South Korea; The Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 03760, South Korea. Electronic address:

Osteoclast-associated receptor (OSCAR) is a member of the leukocyte receptor complex (LRC)-encoded protein family, which is characterized by the presence of immunoglobulin (Ig)-like domains. OSCAR recognizes collagen and was first identified as a co-stimulatory receptor that is needed for complete osteoclast differentiation. However, it is now clear that OSCAR is also expressed by multiple immune cells that participate in many innate and adaptive immune cell activities. Read More

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Assessing central sensitization with quantitative sensory testing in inflammatory rheumatic diseases: A systematic review.

Joint Bone Spine 2022 Apr 30;89(5):105399. Epub 2022 Apr 30.

INSERM U987, Paris, France; Centre d'évaluation et traitement de la douleur, GHU Paris centre-Cochin, Paris, France; Université de Paris, Paris, France.

The major therapeutic challenge in inflammatory rheumatic diseases is the persistence of pain despite good responses to specific therapies. Central sensitization, which can be assessed clinically by psychophysical measurements, including quantitative sensory testing (QST), is a widely proposed mechanism for chronic pain. In this systematic review, we explored the scientific literature addressing quantitative sensory testing in inflammatory rheumatic diseases. Read More

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Lack of association between the TNFAIP3 rs2230926 variant and rheumatoid arthritis-associated lymphoma.

Joint Bone Spine 2022 Apr 28;89(5):105390. Epub 2022 Apr 28.

Department of Rheumatology, FHU CARE, AP-HP, Hôpital Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France; Université Paris-Saclay, Inserm UMR1184, Center for immunology of viral infections and autoimmune diseases, Le Kremlin-Bicêtre, France.

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Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.

Ann Rheum Dis 2022 Apr 25. Epub 2022 Apr 25.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Objectives: To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets.

Methods: We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and ~1 million controls from Northwestern Europe. We searched for causal genes outside the HLA-locus through effect on coding, mRNA expression in several tissues and/or levels of plasma proteins (SomaScan) and did network analysis (Qiagen). Read More

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The Influence of Reducing Disease Activity Score on Cervical Spine Deformity in Rheumatoid Arthritis: A Systematic Review.

Biomed Res Int 2022 15;2022:9403883. Epub 2022 Apr 15.

Department of Neurosurgery, Leiden University Medical Centre, Leiden, Netherlands.

Background: Rheumatoid arthritis (RA) can cause deformity in particularly the craniocervical but also in the lower cervical region.

Objectives: The aim of this study is to give an overview of current literature on the association of disease activity score (DAS) and the prevalence and progression of rheumatoid arthritis-associated cervical spine deformities.

Methods: A literature search was done in PubMed, Embase, and Web of Science using a sensitive search string combination (Supplemental File). Read More

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Postoperative outcomes after degenerative lumbar spine surgery in rheumatoid arthritis patients -a propensity score-matched analysis.

BMC Musculoskelet Disord 2022 Apr 22;23(1):380. Epub 2022 Apr 22.

Department of Orthopaedic Surgery, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Although treatment options for rheumatoid arthritis (RA) have evolved significantly since the introduction of biologic agents, degenerative lumbar disease in RA patients remains a major challenge. Well-controlled comparisons between RA patients and their non-RA counterparts have not yet been reported. The objective of the present study was to compare postoperative outcomes of lumbar spine surgery between RA and non-RA patients by a retrospective propensity score-matched analysis. Read More

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Bone Scan With SPECT/CT Demonstrated C1 to C2 Involvement in Rheumatic Arthritis.

Clin Nucl Med 2022 Jul 22;47(7):661-663. Epub 2022 Apr 22.

Department of Medical Imaging, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.

Abstract: An 80-year-old man was treated with rituximab for active rheumatoid arthritis until 2019, now controlled with Salazopyrin, prednisolone, methotrexate, and folic acid. However, laboratory data showed elevated C-reactive protein and erythrocyte sedimentation rate. Whole-body bone scan showed bony and joint destruction to the upper cervical vertebra (C spine), bilateral shoulders, wrists, finger joints, ankles, and left knee. Read More

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Risk of bacteraemia in patients with rheumatoid arthritis and the effect of orthopaedic implants on the risk: a nationwide observational cohort study.

Scand J Rheumatol 2022 Apr 20:1-9. Epub 2022 Apr 20.

Copenhagen Center for Arthritis Research (COPECARE), Centre for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.

Objective: It remains disputed how much the risk of bacteraemia (SAB) is increased in patients with rheumatoid arthritis (RA), and the extent to which orthopaedic implants explain the risk. We assessed SAB incidence rates (IRs) and incidence rate ratios (IRRs), comparing RA patients with a general population cohort (GPC) and individuals with versus without orthopaedic implants.

Method: Danish residents aged ≥ 18 years without prior RA or SAB (=GPC) were followed up for RA and microbiologically verified SAB events (1996-2017). Read More

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COVID-19 infection and hospitalisation risk according to vaccination status and DMARD treatment in patients with rheumatoid arthritis.

Rheumatology (Oxford) 2022 Apr 13. Epub 2022 Apr 13.

Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark.

Objectives: To investigate the incidence of COVID-19 hospitalisation in unvaccinated and vaccinated patients with rheumatoid arthritis (RA) compared with matched controls, and in patients with RA according to DMARD treatment.

Methods: Danish nationwide matched cohort study from January to October 2021. Patients with RA were identified in the DANBIO register and matched 1:20 with individuals from the general population on age, sex, and vaccination status. Read More

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Ochronotic Surprise during Total Knee Replacement! A Case Report.

J Orthop Case Rep 2021 Oct;11(10):49-52

Department of Orthopedics, Lourdes Hospital, Kochi, Kerala, India.

Introduction: Alkaptonuria is a rare autosomal recessive metabolic disorder characterized by accumulation of homogentisic acid (HGA) due to an inherited deficiency of the enzyme HGA oxidase. Unlike rheumatoid arthritis which affects the small joints of the hands and feet, ochronotic arthropathy predominantly involves the large weight-bearing joints such as hips, knees, and spine. The knee is the most common joint to be affected. Read More

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October 2021

A case of adult-onset Grisel's syndrome.

Br J Neurosurg 2022 Apr 8:1-3. Epub 2022 Apr 8.

Department of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano, Japan.

Grisel's syndrome is a non-traumatic subluxation of the atlanto-axial joint that occurs after infection or inflammation in the otolaryngological area, primarily in children. This report describes the clinical characteristics of an extremely rare case of adult-onset Grisel's syndrome. A 77-year-old woman presented with neck and bilateral shoulder pain and stiffness. Read More

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