Semin Arthritis Rheum 2022 08 28;55:152038. Epub 2022 May 28.
University College London Hospital, Department of adolescent and young adult Rheumatology, 250 Euston Road, London NW1 2PG UK; Centre for Adolescent Rheumatology Versus Arthritis, Division of Medicine, University College London, London, UK. Rayne Institute, 5 University St, Bloomsbury, London WC1E 6JF UK; Biomedical Research Centre UCLH UK. Electronic address:
Objectives: To analyse and compare drug-survival of adalimumab and etanercept (and their biosimilars) in biologic-naïve patients with ERA (Enthesitis-Related Arthritis).
Methods: In this retrospective observational study, conventional statistics and machine-learning were applied to compare drug-survival (adalimumab, etanercept and their biosimilars initiated: 2009-2019) in ERA and identify determinants. The primary outcome was discontinuation of treatment due to primary- or secondary-failure and adverse drug-reactions. Read More