6,907 results match your criteria Rheumatoid Arthritis Hands


Seropositive Rheumatoid Arthritis with Very Unusual X-ray Findings.

Eur J Case Rep Intern Med 2018 26;5(7):000883. Epub 2018 Jul 26.

Rheumatology Department, Hamad General Hospital, Doha, Qatar.

We described the case of a 23-year-old Nepalese man with seropositive rheumatoid arthritis and abnormal x-ray findings, found to be due to a very rare bone disease: Camurati Engelmann disease or progressive diaphyseal dysplasia (PDD). This is the first case reported in the Gulf area, although approximately 300 cases have been described worldwide. These patients usually present with limb pain and easy fatigability. Read More

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http://dx.doi.org/10.12890/2018_000883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346779PMC

Hand grip endurance moderating the effect of grip force on functional ability and disease activity in rheumatoid arthritis patients: a cross-sectional study.

Rheumatol Int 2019 Feb 12. Epub 2019 Feb 12.

University Department of Rheumatology, Physical and Rehabilitation Medicine, Clinical Hospital Centre Sestre milosrdnice, Vinogradska 29, HR-10.000, Zagreb, Croatia.

To examine the effect of endurance on the relationship between grip force and measures of functional capacity and disease activity, we performed a cross-sectional study at the University Department of Rheumatology, Physical medicine and Rehabilitation from January 2017 to August 2018. Functional capacity of the hand was measured by ABILHAND-RA questionnaire and disease activity was assessed by the Disease Activity Score (DAS-28-CRP). All participants underwent dynamometric measurements of maximal grip force and hand grip endurance during repeated gripping. Read More

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http://dx.doi.org/10.1007/s00296-019-04250-7DOI Listing
February 2019

An integrated proteomic and glycoproteomic study for differences on glycosylation occupancy in rheumatoid arthritis.

Anal Bioanal Chem 2019 Feb 7. Epub 2019 Feb 7.

Center for Diagnostics & Therapeutics and Department of Chemistry, Georgia State University, 50 Decatur St SE, Atlanta, GA, 30303, USA.

Rheumatoid arthritis (RA) is an autoimmune disease in which certain immune cells are dysfunctional and attack their own healthy tissues. There has been great difficulty in finding an accurate and efficient method for the diagnosis of early-stage RA. The present shortage of diagnostic methods leads to the rough treatments of the patients in the late stages, such as joint removing. Read More

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http://dx.doi.org/10.1007/s00216-018-1543-3DOI Listing
February 2019
2 Reads

US-Guided Biopsies: Overarching Principles.

Front Med (Lausanne) 2019 22;6. Epub 2019 Jan 22.

Department of Rheumatology, Université de Genève, Geneva, Switzerland.

Gathering synovial tissue from any swollen joint especially in early arthritis patients is critical for good quality research and to obtain further insight into the pathophysiology of inflammatory joint diseases. Multiplying biopsy sites is a challenge in terms of the techniques needed for each different joint but also in terms of safety and tolerability. It is important to provide the best care especially in very early arthritis patients who have only had the disease for a few months. Read More

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https://www.frontiersin.org/article/10.3389/fmed.2019.00001/
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http://dx.doi.org/10.3389/fmed.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349745PMC
January 2019
3 Reads

Survival Rate on a 10-Year Follow-Up of Total Wrist Replacement Implants: A 23-Patient Case Series.

J Wrist Surg 2019 Feb 7;8(1):24-29. Epub 2018 Aug 7.

Department of Hand Surgery, SOS main, CCOM, University Hospital of Strasbourg, FMTS, University of Strasbourg, Illkirch, France.

 According to current literature, the estimated average survival rate for Remotion, the total wrist implants, is above 90% on an 8-year follow-up. We examined our series of Remotion to calculate its survival rate on a 10-year follow-up.  A total of 23 cases of total wrist implants were reviewed. Read More

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http://dx.doi.org/10.1055/s-0038-1668152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358454PMC
February 2019
2 Reads

Ultrasonographic criteria for the diagnosis of erosive rheumatoid arthritis using osteoarthritic patients as controls compared to validated radiographic criteria.

Joint Bone Spine 2019 Jan 31. Epub 2019 Jan 31.

Department of Rheumatology, University Hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France; INSERM, CIC-EC CIE6, University Hospital of Nancy, Epidemiology and Clinical Evaluation, 54500 Vandoeuvre-lès-Nancy, France.

Objectives: The aims of this study were to compare characteristics of radiography (RX) and ultrasound (US) erosive lesions in rheumatoid arthritis (RA) and osteoarthritis (OA) patients (prevalence, topography and severity), to determine thresholds for the diagnosis of erosive RA based on US and to evaluate the performance of US and RX to establish a diagnosis of erosive RA differentiated from hand OA.

Methods: Patients fulfilling ACR 1987 and/or ACR/EULAR 2010 criteria for RA or ACR hand OA criteria were prospectively included. A modified Sharp erosion score was assessed by two blinded readers and one adjudicator for discordant cases (number of eroded joints ≤ three). Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.011DOI Listing
January 2019
1 Read

The Multifaceted S100A4 Protein in Cancer and Inflammation.

Methods Mol Biol 2019 ;1929:339-365

Faculty of Health, Department of Neuroscience, Copenhagen University, Copenhagen, Denmark.

The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been discovered as a potent factor implicated in various inflammation-associated diseases. S100A4 is involved in a range of biological functions such as angiogenesis, cell differentiation, apoptosis, motility, and invasion. Moreover, S100A4 is also a potent trigger of inflammatory processes and induces the release of cytokines and growth factors under different pathological conditions. Read More

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http://link.springer.com/10.1007/978-1-4939-9030-6_22
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http://dx.doi.org/10.1007/978-1-4939-9030-6_22DOI Listing
January 2019
3 Reads

Repair of Erosions in Patients with Rheumatoid Arthritis.

J Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

From Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology, Lund; Department of Research and Education, Skånevård Sund, Region Skåne, Helsingborg´s Hospital, Helsingborg, Sweden. This study was supported by grants from the Swedish Rheumatism Association, and the Foundation for Assistance to Disabled People in Skåne (Stiftelsen för Bistånd åt Rörelsehindrade i Skåne). K. Forslind, Associate Professor, Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology, and the Department of Research and Education, Skånevård Sund, Region Skåne, Helsingborg's Hospital; K. Eberhardt, Associate Professor, Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology; B. Svensson, Associate Professor, Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology. Address correspondence to K. Forslind, Department of Research and Education, Skånevård Sund, Region Skåne, Helsingborg's Hospital, 25187 Helsingborg, Sweden. E-mail: Accepted for publication October 16, 2018.

Objective: The aim of this study was to examine the occurrence of repair in a cohort of conventionally treated patients with early rheumatoid arthritis over 8 years.

Methods: There were 395 patients included in the BARFOT study having radiographs of hands and feet at inclusion, and at 1, 2, 5, and 8 years, which were chronologically scored for erosions by the Sharp/van der Heijde method. An erosion with repair was defined as an erosion that has become partially or totally filled, with or without sclerosis. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180557
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http://dx.doi.org/10.3899/jrheum.180557DOI Listing
February 2019
2 Reads

Intravoxel incoherent motion MRI for discrimination of synovial proliferation in the hand arthritis: A prospective proof-of-concept study.

J Magn Reson Imaging 2019 Jan 31. Epub 2019 Jan 31.

Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Background: Postcontrast-enhanced MRI is currently the reference standard for synovial proliferation in rheumatoid arthritis (RA). However, the technique is somewhat invasive due to the use of gadolinium contrast agents, which may cause severe adverse/side effects. Intravoxel incoherent motion (IVIM) simultaneously permits quantification of perfusion as well as diffusion using a single imaging scan. Read More

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http://dx.doi.org/10.1002/jmri.26660DOI Listing
January 2019

Prevalence and distribution of cartilage damage at the metacarpal head level in rheumatoid arthritis and osteoarthritis: an ultrasound study.

Rheumatology (Oxford) 2019 Jan 25. Epub 2019 Jan 25.

Rheumatology Department, Università Politecnica delle Marche, C. Urbani Hospital, Jesi, Ancona, Italy.

Objectives: To determine the prevalence and distribution of US-detected qualitative cartilage damage at metacarpal heads of patients with RA and hand OA.

Methods: Fifty-two RA patients and 34 patients with hand OA were enrolled. US examination of the metacarpal head cartilage from the II to V finger of both hands was performed. Read More

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http://dx.doi.org/10.1093/rheumatology/key443DOI Listing
January 2019
4.475 Impact Factor

"Carpal tunnel syndrome:" A bibliometric study of 35 years of research.

Authors:
Shri Ram

Neurol India 2019 Jan-Feb;67(Supplement):S55-S61

Central Library, Thapar Institute of Engineering and Technology, Patiala, Punjab, India.

Carpal tunnel syndrome (CTS) is a disease caused by compression of the median nerve passing through the wrist. Patients suffer from severe pain and paresthesis in the median nerve. Compression of the median nerve occurs, with prolonged working on keyboards (computer or laptop or music players) being one of the reasons along with others such as diabetes or rheumatoid arthritis. Read More

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http://dx.doi.org/10.4103/0028-3886.250698DOI Listing
January 2019
5 Reads

Treatment of Periprosthetic Humeral Shaft Fracture after Total Elbow Arthroplasty in an Osteoporotic Patient, using the Ilizarov External Ring Fixator: A Case Report.

J Orthop Case Rep 2018 Jul-Aug;8(4):82-85

Department of Orthopaedic Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Introduction: Periprosthetic humeral shaft fracture after total elbow arthroplasty (TEA) and open reduction and internal fixation at the same side humeral neck fracture in patients with osteoporosis poses a treatment challenge. Herein, we describe our experience with its treatment using the Ilizarov external ring fixator.

Case Report: A 74-year-old Japanese woman with rheumatoid arthritis and osteoporosis sustained a periprosthetic humeral shaft fracture. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343564PMC
January 2019
1 Read

Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity.

Front Immunol 2018 9;9:3057. Epub 2019 Jan 9.

Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

Galectins, a family of animal lectins, play central roles in immune system regulation, shaping both innate and adaptive responses in physiological and pathological processes. These include rheumatoid arthritis (RA), a chronic multifactorial autoimmune disease characterized by inflammatory responses that affects both articular and extra-articular tissues. Galectins have been reported to play central roles in RA and its experimental animal models. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333668PMC
January 2019

The Capitate-to-Axis-of-Radius Distance (CARD): A New Radiographic Measurement for Wrist and Carpal Alignment in the Sagittal Plane.

J Hand Surg Am 2019 Jan 23. Epub 2019 Jan 23.

Roth McFarlane Hand and Upper Limb Centre, St. Joseph's Hospital, London, Ontario, Canada.

Purpose: To determine the reliability of a new radiographic index evaluating sagittal radiocarpal alignment, the capitate-to-axis-of-radius distance (CARD). A secondary purpose was to validate this index by comparing values between normal wrists and those with distal radial fractures (DRFs) and rheumatoid arthritis (RA).

Methods: The CARD is defined as the perpendicular distance from the center of the capitate head to the axis of the radius. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03635023163082
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http://dx.doi.org/10.1016/j.jhsa.2018.10.024DOI Listing
January 2019
4 Reads

Revisiting the disabilities of the arm, shoulder and hand (DASH) and QuickDASH in rheumatoid arthritis.

BMC Musculoskelet Disord 2019 Jan 25;20(1):41. Epub 2019 Jan 25.

Division of Nursing, Midwifery & Social Work, University of Manchester, Manchester, UK.

Background: Limitations in upper limb functioning are common in Musculoskeletal disorders and the Disabilities of the Arm, Shoulder and Hand scale (DASH) has gained widespread use in this context. However, various concerns have been raised about its construct validity and so this study seeks to examine this and other psychometric aspects of both the DASH and QuickDASH from a modern test theory perspective.

Methods: Participants in the study were eligible if they had a confirmed diagnosis of Rheumatoid Arthritis (RA). Read More

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http://dx.doi.org/10.1186/s12891-019-2414-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347833PMC
January 2019
1 Read

Elucidating the risk factors for chronic obstructive pulmonary disease: an umbrella review of meta-analyses.

Int J Tuberc Lung Dis 2019 Jan;23(1):58-66

Departments of Hygiene and Epidemiology, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Chronic obstructive pulmonary disease (COPD) is commonly attributed to smoking, and other potential risk factors are ignored. We aimed to critically appraise the epidemiological credibility of the risk factors for COPD that have been examined in published meta-analyses. We performed a systematic search to capture systematic reviews and meta-analyses of observational studies on environmental factors and biomarkers for risk of COPD. Read More

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https://www.ingentaconnect.com/content/10.5588/ijtld.18.0228
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http://dx.doi.org/10.5588/ijtld.18.0228DOI Listing
January 2019
3 Reads

Hand strength in patients with RA correlates strongly with function but not with activity of disease.

Adv Rheumatol 2018 Aug 3;58(1):20. Epub 2018 Aug 3.

Faculty of Medicine of Marilia (Famema), Marília, SP, Brazil.

Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints, especially of the hands. The evaluation of handgrip strength (HS) and pinch strength can be useful to detect reduction in hand function in RA patients. The aim of the study was to compare HS and pinch strength between RA patients (RA Group - RAG) and a non-RA control group (CG) and to relate HS and pinch strength to functional capacity, duration and disease activity in the RAG. Read More

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https://advancesinrheumatology.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s42358-018-0020-1DOI Listing
August 2018
7 Reads

[Cardiovascular comorbidities in rheumatoid arthritis].

Z Rheumatol 2019 Jan 17. Epub 2019 Jan 17.

Gemeinschaftspraxis für Rheumatologie, Nürnberg, Deutschland.

Approximately 80% of patients with rheumatoid arthritis (RA) suffer from comorbidities including more than 50% from cardiovascular (CV) diseases. Inflammatory activity is the main factor connecting RA with atherosclerosis, coronary heart disease, stroke, thromboembolic events and heart failure. Altogether these affect RA patients twice as frequently as the general population and CV events are the major cause of death in RA. Read More

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http://link.springer.com/10.1007/s00393-018-0584-5
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http://dx.doi.org/10.1007/s00393-018-0584-5DOI Listing
January 2019
4 Reads

Benefits of wrist splinting in patients with rheumatoid arthritis.

Reumatologia 2018 23;56(6):362-367. Epub 2018 Dec 23.

Rheumatology Clinic and Outpatient Department, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Objectives: The goal was to present the use of a functional wrist splint and its impact on hand function in patients with rheumatoid arthritis (RA).

Material And Methods: The study group comprised 104 women aged 18-65 and diagnosed with RA, who were treated in the Rheumatology Clinic and Outpatient Department of the National Institute of Geriatrics, Rheumatology and Rehabilitation in Warsaw. The control group consisted of 40 healthy women in the same age group. Read More

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https://www.termedia.pl/doi/10.5114/reum.2018.80713
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http://dx.doi.org/10.5114/reum.2018.80713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330686PMC
December 2018
10 Reads

The importance of ultrasound examination in early arthritis.

Reumatologia 2018 23;56(6):354-361. Epub 2018 Dec 23.

Department of Pharmacology, Wrocław Medical University, Wrocław, Poland.

Objectives: To assess the importance of ultrasound (US) examination of joints in hands and feet in patients with early arthritis and perform comparative analysis of the diagnostic value of US examination for 8, 12 and 52 selected joints.

Material And Methods: 123 patients (87 women, 36 men) with arthritis lasting less than 12 months, naive to disease-modifying anti-rheumatic drugs and glucocorticosteroids. Necessary differential diagnostics was performed for each patient. Read More

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https://www.termedia.pl/doi/10.5114/reum.2018.80712
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http://dx.doi.org/10.5114/reum.2018.80712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330678PMC
December 2018
5 Reads

Use of Magnetic Resonance Imaging to Support Dose Selection in a Phase II Trial of Baricitinib Combined with Conventional Synthetic Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From Spire Sciences, Inc. Boca Raton, FL, USA, The Leeds Institute of Rheumatic & Musculoskeletal Medicine, University of Leeds, Leeds, UK, Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA, Department of Rheumatology, University of Toronto, Toronto, ON, Canada, Botnar Research Centre, University of Oxford, Oxford, UK, Eli Lilly and Company, Indianapolis, IN, USA, Incyte Corporation, Wilmington, DE, USA Note: Dr. DiCarlo was an employee of Spires Science, Inc. at the time of this study; Dr. Luchi was an employee of Incyte Corporation at the time the study). This study was funded by Eli Lilly and Company and Incyte Corporation.

Objective: Magnetic resonance imaging (MRI) was used in a Phase IIb study (NCT01185353) of baricitinib in patients with RA to support dose selection for the Phase III program.

Methods: 301 patients with active RA on stable methotrexate were randomized 2:1:1:1:1 to placebo or once-daily baricitinib (1-, 2-, 4-, or 8-mg) for up to 24 weeks. 154 patients with definitive radiographic erosion had MRI of the hand/wrist at baseline and weeks 12 and 24. Read More

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http://dx.doi.org/10.3899/jrheum.171469DOI Listing
January 2019
2 Reads

The value of the simplified RAMRIS-5 in early RA patients under methotrexate therapy using high-field MRI.

Arthritis Res Ther 2019 Jan 14;21(1):21. Epub 2019 Jan 14.

Department and Hiller Research Unit for Rheumatology, UKD, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.

Background: The aim of the study was to evaluate a simplified version of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) for five joints of the hand (RAMRIS-5) in patients with early rheumatoid arthritis (RA) before and after the initiation of methotrexate (MTX) therapy using high-resolution, 3-T magnetic resonance imaging (MRI).

Methods: Twenty-eight patients with a seropositive, early RA (disease duration of less than 6 months (range 2-23 weeks)) according to 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria (mean age 56.8 years, range 39-74) were prospectively assessed with a baseline investigation including clinical assessment (disease activity score of 28 joints (DAS-28) and C-reactive protein (CRP)) and 3-T MRI of the clinically dominant hand. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1789-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332674PMC
January 2019
4 Reads
3.753 Impact Factor

Total Elbow Arthroplasty.

J Hand Surg Am 2019 Jan 8. Epub 2019 Jan 8.

Harvard Medical School, Boston, MA; Department of Orthopaedic Surgery, Massachusetts Hospital, Boston, MA.

Total elbow arthroplasty design has evolved in recent decades. Indications for total elbow arthroplasty include advanced rheumatoid arthritis to osteoarthritis, post-traumatic arthritis, adverse sequelae of trauma, and unreconstructable acute fractures. This article summarizes the current evidence for total elbow arthroplasty, including the history of total elbow arthroplasty, an overview of the recent trends and designs, and current evidence-based outcomes. Read More

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http://dx.doi.org/10.1016/j.jhsa.2018.11.005DOI Listing
January 2019
11 Reads

[Senile rheumatoid arthritis associated with rheumatoid lung: a caricatural observation].

Pan Afr Med J 2018 6;30:253. Epub 2018 Aug 6.

Service de Médecine Interne B, Hôpital Charles Nicolle, Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisie.

In the elderly, rheumatoid arthritis is defined by an average age of onset over 60 years. Prognosis mainly depends upon functional capacity, evolutionary stage of the disease, onset or no onset of joint malformations. We report the case of a 70-year old female patient with a history of arterial hypertension, hypothyroidism and Sjögren syndrome diagnosed in 2005. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.253.16372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307917PMC
January 2019
8 Reads

Geriatric syndromes in patients with rheumatoid arthritis: a literature overview.

Clin Exp Rheumatol 2018 Dec 19. Epub 2018 Dec 19.

Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, School for Public Health and Primary Care (CAPHRI), Maastricht University, The Netherlands.

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease of unknown aetiology which principally affects the small joints of the hands and feet. The incidence of RA increases with age and peaks within the age range of 70 to 79 years. In the ageing population, therefore, it is expected that the number of patients with RA will grow proportionally and more patients will have comorbidities but also so-called geriatric syndromes (GS). Read More

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December 2018
5 Reads

Hand tendinopathy risk factors in Taiwan: A population-based cohort study.

Medicine (Baltimore) 2019 Jan;98(1):e13795

Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan.

De Quervain's disease, carpal tunnel syndrome (CTS), and trigger finger (digit) are three common pathological conditions of the hand. They are considered overuse syndromes and occur predominantly in females. The prevalence rate and cause-specific risks of these three tendinopathies have not yet been clarified. Read More

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http://dx.doi.org/10.1097/MD.0000000000013795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344158PMC
January 2019
1 Read

Inhibition of tumor necrosis factor-alpha (TNF-alpha) in patients with early rheumatoid arthritis results in acute changes of bone modulators.

Int Immunopharmacol 2019 Feb 31;67:487-489. Epub 2018 Dec 31.

Rheumatology Unit, University of Verona, Ospedale Civile Maggiore, Piazzale A. Scuro, 37134 Verona, Italy.

Objective: Dicckopf-1 (Dkk-1) is a potent inhibitor of the Wnt canonical pathway. In rheumatoid arthritis (RA), Dkk-1 is upregulated by tumor necrosis factor-α (TNF). Certolizumab pegol (CMZ) is a biologic TNF-inhibitor (TNFi) effective in RA and slows radiographic progression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183103
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http://dx.doi.org/10.1016/j.intimp.2018.12.050DOI Listing
February 2019
4 Reads

Should the ultrasound of hands be a component ofrheumatoidarthritis remission criteria?

Curr Rheumatol Rev 2018 Dec 30. Epub 2018 Dec 30.

Rheumatology Department, University Hospital Center Hassan II Fez Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fez. Morocco.

Introduction: The definition of remission in rheumatoid arthritis (RA) is still difficult to determine. An ultrasound of the hands may be important in helping to confirm clinical remission. This study's aim was to evaluate the interest in using an ultrasound of the hands to confirm clinical remission, as well as comparing the various remission scores (DAS 28 VS, DAS 28 CRP, and SDAI) and the ultrasound data, in order to deduce the most accurate score to confirm this remission. Read More

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http://dx.doi.org/10.2174/1573397115666181231115233DOI Listing
December 2018
7 Reads

Safety and Survival Associated with Biologic Therapies: First Report of the Biobadaguay on the Paraguayan-Uruguayan Registry of Adverse Events with Biologic Therapies.

Reumatol Clin 2018 Dec 27. Epub 2018 Dec 27.

Hospital Central del Instituto de Previsión Social, Asunción, Paraguay.

Objective: Analyze adverse events (AE) and survival associated with biologic therapies (BT) in the Biobadaguay, the Paraguayan Uruguayan registry of adverse events.

Methods: Prospective, observational study of undetermined duration. Patients on BT at initiation and controls were included. Read More

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http://dx.doi.org/10.1016/j.reuma.2018.08.009DOI Listing
December 2018
3 Reads

Endoscopic Synovectomy of the Ulnar Bursa of the Palm of the Hand.

Arthrosc Tech 2018 Dec 5;7(12):e1257-e1261. Epub 2018 Nov 5.

Department of Orthopaedics and Traumatology, Tuen Mun Hospital, Tuen Mun, China.

Synovitis of the ulnar bursa is associated with tenosynovitis of the flexor tendons. Reported causes include suppurative or tuberculous infection, rheumatoid arthritis, and pigmented villonodular synovitis. Open synovectomy requires extensive soft-tissue dissection and may result in extensive scarring. Read More

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http://dx.doi.org/10.1016/j.eats.2018.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305889PMC
December 2018
2 Reads

The effectiveness of joint-protection programs on pain, hand function, and grip strength levels in patients with hand arthritis: A systematic review and meta-analysis.

J Hand Ther 2018 Dec 23. Epub 2018 Dec 23.

Physical Therapy and Surgery, Western University, London, ON and Co-director Clinical Research Lab, Hand and Upper Limb Centre, St. Joseph's Health Centre, London, ON; Rehabilitation Science McMaster University, Hamilton, ON, Canada.

Study Design: Systematic review with meta-analysis.

Introduction: Joint protection (JP) has been developed as a self-management intervention to assist people with hand arthritis to improve occupational performance and minimize joint deterioration over time.

Purpose Of The Study: We examined the effectiveness between JP and usual care/control on pain, hand function, and grip strength levels for people with hand osteoarthritis and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/j.jht.2018.09.012DOI Listing
December 2018
2 Reads
1.810 Impact Factor

Inflammatory markers predict insulin sensitivity in active rheumatoid arthritis but not in psoriatic arthritis.

Reumatismo 2018 Dec 20;70(4):232-240. Epub 2018 Dec 20.

Department of Translational Medicine, Università del Piemonte Orientale, Novara; Division of Internal Medicine, Immunorheumatology Unit, Maggiore della Carità Hospital, Novara; Division of Internal Medicine, Sant'Andrea Hospital, Vercelli.

Whether the insulin resistance commonly observed in patients with inflammatory arthritis is a disease-specific feature and/or is limited to a disease phase (i.e., it occurs only during phases of high disease activity) is unknown. Read More

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http://dx.doi.org/10.4081/reumatismo.2018.1061DOI Listing
December 2018
5 Reads

Thermal alterations in patients with inflammatory diseases: a comparison between psoriatic and rheumatoid arthritis.

Reumatismo 2018 Dec 20;70(4):225-231. Epub 2018 Dec 20.

Department of Medicine and Aging Science, Dermatologic Clinic, University G. d'Annunzio, Chieti.

Functional infrared imaging (fIRI) is used to provide information on circulation, thermal properties and thermoregulatory function of the cutaneous tissue in several clinical settings. This study aims to evaluate the application of fIRI in rheumatoid arthritis (RA) assessment, evaluating the thermoregulatory alterations due to joint inflammation in RA patients both in basal conditions and after a mild functional (isometric) exercise, using the same protocol we projected in our recent work on psoriatic arthritis (PsA); fIRI outcomes were compared with those provided by power-Doppler ultrasonography. Ten patients with RA and 11 healthy controls were enrolled in the study. Read More

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http://dx.doi.org/10.4081/reumatismo.2018.1050DOI Listing
December 2018
1 Read

Inhibition of periarticular bone loss is associated with clinical remission and ACR70-Response in rheumatoid arthritis.

Rheumatol Int 2018 Dec 19. Epub 2018 Dec 19.

Institute of Diagnostic and Interventional Radiology, SRH Wald-Klinikum Gera, Straße des Friedens 122, 07548, Gera, Germany.

The aim of this study, based on a post hoc analysis of the data set used in the RAPID 1 trial, focuses on the associations between metacarpal bone mineral density, as estimated by digital X-ray radiogrammetry (DXR), and clinical remission as well as ACR70-Response in rheumatoid arthritis (RA) patients treated with certolizumab pegol (CZP). The trial evaluates a total of 345 RA patients treated with methotrexate versus CZP 200 mg versus CZP 400 mg. All patients underwent X-rays of the hand at baseline and week 52 as well as computerized calculations of bone mineral density (BMD) by DXR. Read More

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http://dx.doi.org/10.1007/s00296-018-4226-7DOI Listing
December 2018
2 Reads

Susceptibility-weighted MR imaging to improve the specificity of erosion detection: a prospective feasibility study in hand arthritis.

Skeletal Radiol 2018 Dec 18. Epub 2018 Dec 18.

Department of Radiology, Charité - Universitätsmedizin Berlin, Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Berlin, Germany.

Objective: To evaluate the diagnostic potential of susceptibility-weighted imaging (SWI) for the detection of erosions of the hand, compared to T1-weighted (T1w) magnetic resonance imaging (MRI). Computed tomography (CT) was used as a reference standard.

Materials And Methods: We prospectively investigated 37 patients with suspected arthritic activity of the hand. Read More

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http://link.springer.com/10.1007/s00256-018-3116-0
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http://dx.doi.org/10.1007/s00256-018-3116-0DOI Listing
December 2018
6 Reads

[A Case of Rheumatoid Arthritis Developed during Treatment with Nivolumab for Renal Cell Carcinoma].

Hinyokika Kiyo 2018 10;64(10):397-401

The Department of Urology, Nara Medical University.

A 66-year-old man underwent nephrectomy for right renal cell carcinoma (cT3bNOMl (PUL)). Thereafter, he was treated with sunitinib for lung metastasis as the first-line therapy for 5 months and then axitinib as the second-line therapy for 2 months. Because lung metastasis progressed despite molecular targeted therapies, nivolumab was used as the third-line treatment. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_10_397DOI Listing
October 2018
3 Reads

Identification of significant ego networks and pathways in rheumatoid arthritis.

J Cancer Res Ther 2018 Dec;14(Supplement):S1024-S1028

Orthopedic Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, 830001, Xinjiang, China.

Objective: The objective of this paper is to identify ego networks and pathways in rheumatoid arthritis (RA) based on EgoNet algorithm and pathway enrichment analysis.

Materials And Methods: The ego networks were identified based on the EgoNet algorithm which was comprised four steps: inputting gene expression data and protein-protein interaction data, identifying ego genes based on topological features of genes in background network, collecting ego networks by conducting snowball sampling for each ego gene, and estimating statistical significance of ego networks utilizing permutation test. To further explore the gene compositions of significant ego networks, pathway enrichment analysis was performed for each of them to investigate ego pathways in the progression of RA. Read More

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http://dx.doi.org/10.4103/0973-1482.189250DOI Listing
December 2018
3 Reads

Assessing prognosis and prediction of treatment response in early rheumatoid arthritis: systematic reviews.

Health Technol Assess 2018 11;22(66):1-294

School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.

Background: Rheumatoid arthritis (RA) is a chronic, debilitating disease associated with reduced quality of life and substantial costs. It is unclear which tests and assessment tools allow the best assessment of prognosis in people with early RA and whether or not variables predict the response of patients to different drug treatments.

Objective: To systematically review evidence on the use of selected tests and assessment tools in patients with early RA (1) in the evaluation of a prognosis (review 1) and (2) as predictive markers of treatment response (review 2). Read More

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http://dx.doi.org/10.3310/hta22660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304732PMC
November 2018
3 Reads

Validity and interpretability of the QuickDASH in the assessment of hand disability in rheumatoid arthritis.

Rheumatol Int 2018 Dec 3. Epub 2018 Dec 3.

Rheumatological Clinic, Ospedale "Carlo Urbani", Università Politecnica delle Marche, Via Aldo Moro, 25, Jesi, 60035, Ancona, Italy.

Objective of this study is to evaluate the construct validity and the interpretability of the shortened Disability of Arm, Shoulder and Hand Questionnaire (QuickDASH) in the assessment of rheumatoid arthritis (RA) hand disability. Consecutive RA patients were assessed through the QuickDASH and other function and disease activity indices, respectively, the Health Assessment Questionnaire-Disability Index (HAQ-DI) and the Recent-Onset Arthritis Disability questionnaire (ROAD). For each patient were evaluated the tender and swollen 28-joints counts. Read More

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http://dx.doi.org/10.1007/s00296-018-4216-9DOI Listing
December 2018
2 Reads

Detection of anti-adalimumab antibodies in a RA responsive cohort of patients using three different techniques.

Anal Biochem 2019 Feb 22;566:133-138. Epub 2018 Nov 22.

Laboratory of Peptide and Protein Chemistry and Biology, PeptLab, Italy; Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmaceutical Sciences and Nutraceutics, University of Florence, Via Ugo Schiff 6, I-50019, Sesto Fiorentino, Italy. Electronic address:

Reliable monitoring of clinical relevant anti-drug antibodies is fundamental in the follow-up of patients under adalimumab treatment. The aim of this study is to compare anti-adalimumab antibodies by using three methods based on different technologies. A cross-sectional study was performed in 50 patients with rheumatoid arthritis (RA) treated with adalimumab. Read More

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http://dx.doi.org/10.1016/j.ab.2018.11.018DOI Listing
February 2019
1 Read

The systematic case-referent method.

Therapie 2018 Oct 26. Epub 2018 Oct 26.

London School of Hygiene and Tropical Medicine, LA Risk Research, London EC1R 5BD, United Kingdom.

The systematic case-referent method is a special case-referent design originally developed for pharmacoepidemiologic research purposes. It consists in the systematic collection of series of incident cases of various disorders and the assembling of a general reference pool, from which "controls" are secondarily selected to be matched to specific cases. Both series are collected independently from each other and with no a priori hypothesis to be investigated. Read More

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http://dx.doi.org/10.1016/j.therap.2018.09.073DOI Listing
October 2018
15 Reads

Comparison of rheumatoid arthritis (RA) and osteoarthritis (OA) based on microarray profiles of human joint fibroblast-like synoviocytes.

Cell Biochem Funct 2019 Jan 23;37(1):31-41. Epub 2018 Nov 23.

Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

The purpose of the present study was to investigate the underlying molecular mechanism of osteoarthritis (OA) and rheumatoid arthritis (RA) based on microarray profiles. Three human joint fibroblast-like synoviocytes (FLSs) microarray profiles including 26 OA samples, 33 RA samples, and 20 healthy control (HC) samples were downloaded from the GEO database. Differentially expressed genes (DEGs) between OA and HC (DEGsOA) and RA and HC (DEGsRA) were identified. Read More

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http://dx.doi.org/10.1002/cbf.3370DOI Listing
January 2019
12 Reads
2.005 Impact Factor

Autoantibodies to heat shock proteins 60, 70, and 90 in patients with rheumatoid arthritis.

Cell Stress Chaperones 2019 Jan 21;24(1):283-287. Epub 2018 Nov 21.

Department of Molecular Biology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.

Heat shock proteins (HSP) have been reported to impact immune responses and to be associated with rheumatoid arthritis (RA). Recently, we provided evidence for a role of autoantibodies to Hsp40 in patients with RA. In this study, we aimed at investigating the humoral autoimmune response to Hsp60, Hsp70, and Hsp90 in RA patients (n = 39). Read More

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http://dx.doi.org/10.1007/s12192-018-0951-9DOI Listing
January 2019
8 Reads

Mixed connective tissue disease complicated by heart failure in Ile-Ife, Nigeria: management challenges in a resource-limited economy.

Int Med Case Rep J 2018 2;11:307-312. Epub 2018 Nov 2.

Department of Cardiology,

Background: Mixed connective tissue disease (MCTD; also known as Sharp's syndrome) is a rare autoimmune inflammatory disorder characterized by high titer of U1 ribonucleoprotein (U1RNP) antibody and clinical and serological overlap of systemic lupus erythematosus, systemic sclerosis, and polymyositis. The diagnosis is based on clinical and serological factors in criteria such as Alarcon-Segovia, Khan, Kusakawa, and Sharps. Cardiac disease can be a complication of connective tissue disease (CTD). Read More

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http://dx.doi.org/10.2147/IMCRJ.S151693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219426PMC
November 2018
12 Reads

Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series.

J Med Chem 2018 Nov 21. Epub 2018 Nov 21.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , West Lafayette , Indiana 47907 , United States.

The present account describes the discovery and development of a new benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) JAK inhibitory chemotype that has produced selective JAK inhibitors. Sequential palladium chemistry was optimized for the rapid access to a focused library of derivatives to explore the structure-activity relationships of the new scaffold. Several compounds from the series displayed potencies in the low nanomolar range against the four members of the JAK family with various selectivity profiles. Read More

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00510
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http://dx.doi.org/10.1021/acs.jmedchem.8b00510DOI Listing
November 2018
10 Reads
5.447 Impact Factor

Is dry heat treatment (fluidotherapy) effective in improving hand function in patients with rheumatoid arthritis? A randomized controlled trial.

Clin Rehabil 2018 Nov 18:269215518810778. Epub 2018 Nov 18.

1 Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Objective:: To evaluate the efficacy of dry heat treatment (fluidotherapy) in improving hand function in patients with rheumatoid arthritis.

Design:: Prospective randomized controlled trial.

Setting:: Departments of Physical Medicine and Rehabilitation and Rheumatology in a university hospital. Read More

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http://dx.doi.org/10.1177/0269215518810778DOI Listing
November 2018
11 Reads

Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis.

Gen Physiol Biophys 2018 Sep 15;37(6):703-710. Epub 2018 Nov 15.

Institute of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

The aim of study was to examine relation among miR-124 and serum levels of selected cytokines and chemokines, MMP-3, production of auto-antibodies, and factors describing clinical activity (DAS28) and radiographic progression in rheumatoid arthritis (RA). A total of 80 RA patients according to the ACR classification criteria, and 32 control subjects were recruited into study. The measurements of miR-124 and U-6 expression, CRP, anti-CCP, rheumatoid factors (RFs), radiographs of both hands with calculation of total sharp score (TSS), DAS28 and cytokines, chemokines and MMP levels in serum were obtained from all RA patients. Read More

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http://dx.doi.org/10.4149/gpb_2018024DOI Listing
September 2018
13 Reads

Cepharanthine suppresses osteoclast formation by modulating the nuclear factor-κB and nuclear factor of activated T-cell signaling pathways.

J Cell Biochem 2018 Nov 13. Epub 2018 Nov 13.

Department of Trauma Orthopedic and Hand Surgery, Research Centre for Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.

The increased activation of osteoclasts is the major manifestation of several lytic bone diseases, including osteoporosis, rheumatoid arthritis, aseptic loosening of orthopedic implants, Paget disease and malignant bone diseases. One important bone-protective therapy in these diseases focuses on the inhibition of osteoclast differentiation and resorptive function. Given that the deleterious side-effects of currently available drugs, it is beneficial to search for effective and safe medications from natural compounds. Read More

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http://dx.doi.org/10.1002/jcb.27495DOI Listing
November 2018
9 Reads
3.263 Impact Factor

Performance of routine assessment of patient index data 3 (RAPID3) in monitoring disease activity of Chinese rheumatoid arthritis patients.

Int J Rheum Dis 2018 Nov 6;21(11):1940-1945. Epub 2018 Nov 6.

Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing, China.

Aim: To explore the performance of routine assessment of patient index data 3 (RAPID3) in reflecting disease activity in Chinese rheumatoid arthritis (RA) patients.

Method: The clinical data of 189 consecutive RA patients, including RAPID3 questionnaire, Disease Activity Score based on 28-joint count (DAS28), clinical disease activity index (CDAI) and simplified disease activity index (SDAI), and ultrasonography of hand and wrist joints were collected. The consistency between RAPID3 and DAS28, CDAI, SDAI in RA patients with different disease activities was performed by Spearman's correlations, kappa and/or weighted kappa coefficients. Read More

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http://doi.wiley.com/10.1111/1756-185X.13405
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http://dx.doi.org/10.1111/1756-185X.13405DOI Listing
November 2018
7 Reads

Pathological roles of the homeostatic chemokine CXCL12.

Cytokine Growth Factor Rev 2018 12 23;44:51-68. Epub 2018 Oct 23.

KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, B-3000 Leuven, Belgium. Electronic address:

CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression of CXCL12 in general, or of a specific CXCL12 splicing variant has been demonstrated in various pathologies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13596101183012
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http://dx.doi.org/10.1016/j.cytogfr.2018.10.004DOI Listing
December 2018
13 Reads