6,956 results match your criteria Rheumatoid Arthritis Hands


Automatic Hand Skeletal Shape Estimation from Radiographs.

IEEE Trans Nanobioscience 2019 Apr 12. Epub 2019 Apr 12.

Rheumatoid arthritis (RA) is an autoimmune disease whose common manifestation involves the slow destruction of joint tissue, damage that is visible in a radiograph. Over time, this damage causes pain and loss of functioning which depends, to some extent, on the spatial deformation induced by the joint damage. Building an accurate model of the current deformation and predicting potential future deformations is an important component of treatment planning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/TNB.2019.2911026DOI Listing

Validation of the HAQ-UP-A (Health Assessment Questionnaire-Upper Limbs-Argentine Version) in Patients With Rheumatoid Arthritis.

Reumatol Clin 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Terapia Ocupacional, Hospital General de Agudos Dr. Enrique Tornú, Ciudad Autónoma de Buenos Aires, Argentina.

HAQ is considered the gold standard for the evaluation of functional capacity in patients with rheumatoid arthritis (RA), even though it does not focus on any particular anatomical region. With the objective of assessing functional disability of the hand in elderly patients with osteoarthritis, Baron et al. used a modified version of the HAQ which was calculated as the mean value for the categories mostly involving the upper extremities and named it 'HAQ-UP'. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reuma.2019.01.004DOI Listing

PPAR-γ agonist pioglitazone protects against IL-17 induced intervertebral disc inflammation and degeneration via suppression of NF-κB signaling pathway.

Int Immunopharmacol 2019 Apr 10;72:138-147. Epub 2019 Apr 10.

Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

Interleukin-17 (IL-17) is the production of T helper type 17 (Th17) cells and has been reported to play a pro-inflammatory role in the immunopathogenesis of intervertebral disc degeneration. Peroxisome proliferator-activated receptor γ (PPAR-γ) activators display anti-inflammatory and anti-degeneration roles in osteoarthritis and rheumatoid arthritis. However, the expression level of PPAR-γ and related regulatory mechanisms in the nucleus pulposus tissues are not clear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.04.012DOI Listing

Fixation of the Various Coronal Plane Fracture Fragments, Including the Entire Coronoid Process, in Patients with Mayo Type IIB Olecranon Fractures - Four Methods for Fixation.

Indian J Orthop 2019 Mar-Apr;53(2):224-231

Department of Orthopedic Surgery, Regional Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, South Korea.

Background: We introduce several methods for fixation of unique Mayo type II olecranon fractures with the coronal plane fragment (CPF) including the entire coronoid process and report the radiological and clinical results through a case series.

Materials And Methods: 12 patients were operated using this method with a mean age of 44 years. CPFs were fixed with concurrent fixation by a locking plate screw for the olecranon in three patients (method 1), cerclage wiring in six patients (method 2), a mini plate in two patients (method 3), and a double-locking plate (method 4) in one patient. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ortho.IJOrtho_42_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415574PMC
April 2019
1 Read

Protective effects of Wang-Bi tablet on bone destruction in collagen-induced arthritis by regulating osteoclast-osteoblast functions.

J Ethnopharmacol 2019 Apr 4:111861. Epub 2019 Apr 4.

Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China. Electronic address:

Ethnopharmacological Relevance: Wang-bi tablet (WB) consists of 17 traditional Chinese medicines and has been used for treating rheumatoid arthritis (RA) in China for many years, however, its pharmacologic mechanism is not clear.

Aim Of Study: The aim of this study was to investigate the therapeutic effect of WB on collagen-induced mouse arthritis and explored the underlying mechanism.

Materials And Methods: DBA/1 mice were used to establish a type II collagen-induced arthritis (CIA) model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.111861DOI Listing
April 2019
2 Reads

Histological Evidence of Intrinsic Muscle Degeneration in Compression Ulnar Neuropathy.

Ann Plast Surg 2019 May;82(5):541-545

Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.

Purpose: We investigated the histological characteristics of the tissues in the intrinsic hand muscles of patients with compressive ulnar neuropathy (CUN) to determine how the compromised nerve influences the target muscle.

Methods: In total, 83 patients underwent surgery for CUN in our institution between March 2015 and August 2017. Of these, 45 patients who met our inclusion/exclusion criteria were initially included in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SAP.0000000000001853DOI Listing
May 2019
2 Reads

Comparison of median nerve stiffness with and without rheumatoid arthritis by ultrasound real-time tissue elastography: A propensity score matching study.

Mod Rheumatol 2019 Apr 5:1-17. Epub 2019 Apr 5.

b Department of Orthopaedic Surgery , Osaka City University Graduate School of Medicine , Osaka , Japan.

Objectives: This study aimed to compare median nerve stiffness measured by ultrasound real-time tissue elastography in patients with and without rheumatoid arthritis (RA and non-RA groups, respectively).

Methods: Altogether, 402 hands of 201 RA group and 222 hands of 111 non-RA group were included in the study. Ultrasonography was performed to evaluate the circumference, cross-sectional area (CSA) and strain ratio as an elasticity of the median nerve at the inlet level of the carpal tunnel and the proximal portion of the carpal tunnel inlet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14397595.2019.1602914DOI Listing
April 2019
9 Reads

Subchondral Cyst-Like Lesion of the Hand in a Patient With Rheumatoid Arthritis.

J Clin Rheumatol 2019 Apr 3. Epub 2019 Apr 3.

From the Division of Rheumatology, Agios Andreas Hospital, Patras, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000001033DOI Listing
April 2019
2 Reads

Comparison of fluorescence optical imaging, ultrasonography and clinical examination with magnetic resonance imaging as a reference in active rheumatoid arthritis patients.

Immunol Med 2018 Jun 7;41(2):75-81. Epub 2018 Sep 7.

a Department of Rheumatology , Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.

Background: Fluorescence optical imaging with indocyanine-green enhancement (FOI) is a new imaging modality for the assessment of hand arthritis. The objective of this study was to compare performance profiles of clinical examination (CE), US and FOI using MRI as a reference in the same active rheumatoid arthritis (RA) patients.

Methods: CE, US, FOI and MRI were performed on six subjects with active RA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13497413.2018.1481578DOI Listing
June 2018
1 Read

Early Clinical Response and Long-Term Radiographic Progression in Recent-Onset Rheumatoid Arthritis: Clinical Remission within Six Months Remains the Treatment Target.

Joint Bone Spine 2019 Mar 27. Epub 2019 Mar 27.

Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC). 1200 Bruxelles, Belgium; Service de rhumatologie, Cliniques universitaires Saint-Luc, 1200 Bruxelles, Belgium. Electronic address:

Objectives: The primary objective was to evaluate the correlation between 5-year radiographic structural disease progression and early clinical remission in recent-onset rheumatoid arthritis (RA). The secondary objective was to assess the correlation between erosion development in joints free of damage at baseline and early clinical remission.

Methods: A single-center retrospective study was performed in 133 patients meeting ACR criteria for RA of recent onset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbspin.2019.03.008DOI Listing
March 2019
2 Reads

Multistate Comparison of Cost, Trends, and Complications in Open Versus Endoscopic Carpal Tunnel Release.

Hand (N Y) 2019 Mar 29:1558944719837020. Epub 2019 Mar 29.

2 NYU Langone Health, Brooklyn, NY, USA.

Background: Surgical carpal tunnel release is performed by either open carpal tunnel release (OCTR) or endoscopic carpal tunnel release (ECTR). The purpose of this study was to assess differences in intraoperative and postoperative complications, trends, and costs between OCTR and ECTR.

Methods: State Ambulatory Surgery and Services Databases (SASD) files for California, Florida, and New Jersey were queried for patients who underwent OCTR and ECTR between 2000 and 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1558944719837020DOI Listing
March 2019
1 Read

Influences of miR-320a on proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis through targeting MAPK-ERK1/2.

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):1907-1914

Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: To study the expression of micro ribonucleic acid (miR)-320a in synovial tissues of patients with rheumatoid arthritis (RA) and explore the influences of miR-320a on the proliferation and apoptosis of fibroblast-like synoviocytes (FLSs) in RA and its mechanism.

Patients And Methods: The expression level of miR-320a in synovial tissues of 40 healthy people and 32 RA patients was detected via reverse transcription-polymerase chain reaction (RT-PCR). The FLSs were isolated from RA patients, cultured in vitro and divided into Control group and miR-320a mimic group. Read More

View Article

Download full-text PDF

Source
http://www.europeanreview.org/article/17228
Publisher Site
http://dx.doi.org/10.26355/eurrev_201903_17228DOI Listing
March 2019
3 Reads

[Metacarpophalangeal joint replacement].

Orthopade 2019 Mar 26. Epub 2019 Mar 26.

Handchirurgie, Vulpius Klinik, Vulpiusstraße 29, 74906, Bad Rappenau, Deutschland.

Background: Arthroplasty of metacarpophalangeal (MCP) joints is crucial for patients with rheumatoid arthritis. Motion preserving therapies are mandatory for this joint, since loss of function of the MCP joint is detrimental. Many protheses or spacers have been introduced over the last 80 years, but most of them have been dismissed due to major complications. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00132-019-03715-8
Publisher Site
http://dx.doi.org/10.1007/s00132-019-03715-8DOI Listing
March 2019
1 Read

Surgical Treatment of Tenosynovitis of Extensor Tendons of Fourth Compartment of Wrist in Nonrheumatoid Patients-A Case Series of 10 Patients in India.

J Hand Microsurg 2019 Apr 27;11(1):45-49. Epub 2018 Sep 27.

Department of Orthopaedics, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India.

Proliferative tenosynovitis of the extensor tendons is a very common painful wrist condition that can occur both in presence and absence of rheumatoid arthritis (RA). This study aims to evaluate a series of patients without RA, having extensor tendon tenosynovitis, its pathology, and results of surgical treatment. A consecutive series of 10 patients without RA, having tenosynovitis of fourth extensor compartment were treated surgically and evaluated in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1669368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431284PMC
April 2019
1 Read

MRI inflammation of the hand interosseous tendons occurs in anti-CCP-positive at-risk individuals and may precede the development of clinical synovitis.

Ann Rheum Dis 2019 Mar 23. Epub 2019 Mar 23.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK

Interosseous tendon inflammation (ITI) has been described in rheumatoid arthritis (RA). Whether ITI occurs in at-risk individuals before the onset of clinical synovitis is unknown.

Objectives: To investigate, by MRI, ITI in anti-cyclic citrullinated peptide (CCP)-positive at-risk individuals (CCP +at risk) and to describe the anatomy, prevalence and clinical associations across the RA continuum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2018-214331DOI Listing
March 2019
1 Read

Helminth therapy for autism under gut-brain axis- hypothesis.

Med Hypotheses 2019 Apr 19;125:110-118. Epub 2019 Feb 19.

Department of Pathology and Laboratory Medicine, UC Davis School of Medicine; Institute for Pediatric Regenerative Medicine and Shriners Hospitals for Children of Northern California, United States. Electronic address:

Autism is a neurodevelopmental disease included within Autism Syndrome Disorder (ASD) spectrum. ASD has been linked to a series of genes that play a role in immune response function and patients with autism, commonly suffer from immune-related comorbidities. Despite the complex pathophysiology of autism, Gut-brain axis is gaining strength in the understanding of several neurological disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.02.042DOI Listing
April 2019
1 Read

Trends in Primary Proximal Interphalangeal Joint System and Revisions for Osteoarthritis of the Hand in the Medicare Database.

Hand (N Y) 2019 Mar 21:1558944719837009. Epub 2019 Mar 21.

2 Holy Cross Hospital, Fort Lauderdale, FL, USA.

Background: Proximal interphalangeal arthroplasty (PIPA) has been indicated for patients suffering from osteoarthritis (OA) or rheumatoid arthritis of the hand. Although there is extensive literature showing the outcomes of PIPA, there is paucity in the literature regarding trends of PIPA in patients with OA of the hand. The purpose of this study was to determine annual primary utilization and revision PIPA trends within the Medicare population with the use of an administrative database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1558944719837009DOI Listing
March 2019
2 Reads

Combination of ultrasound power Doppler-verified synovitis and seropositivity accurately identifies patients with early-stage rheumatoid arthritis.

Int J Rheum Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Aim: We conducted this retrospective study to identify objective and comprehensive diagnostic criteria for early-stage rheumatoid arthritis (RA) that are based on ultrasound (US) and serologic findings.

Method: From August 2014 to May 2016, we recruited 216 consecutive patients at Hospital 1 and 223 consecutive patients at Hospital 2 who were suspected to have RA and underwent US of bilateral hands. In the US of bilateral hands from 22 sites, the findings obtained by grayscale and power Doppler (PD) assessments were each graded on a semi-quantitative scale from 0 to 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1756-185X.13543DOI Listing

Joint Mobilization of the Hands of Patients With Rheumatoid Arthritis: Results From an Assessor-Blinded, Randomized Crossover Trial.

J Manipulative Physiol Ther 2019 Mar 14. Epub 2019 Mar 14.

Musculoskeletal & Sports Injury Epidemiology Center, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Objective: The purpose of this study was to assess the clinical feasibility and effectiveness of manual mobilization of the hands of patients with rheumatoid arthritis (RA).

Methods: A total of 320 individual hand joints were evaluated after recruiting an experimental research group of 12 participants with RA and, for clinical comparability, 8 participants with hand osteoarthritis (OA). One hand per participant was randomized to receive weekly low-grade (I-II) Kaltenborn manual mobilization, using passive sustained stretch of the metacarpophalangeal (MCP) joints II to V by licensed manual therapists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmpt.2018.04.007DOI Listing

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients.

Ann Rheum Dis 2019 Mar 16. Epub 2019 Mar 16.

Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK

Objectives: To unravel the hierarchy of cellular/molecular pathways in the disease tissue of early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship with clinical phenotypes and treatment response/outcomes longitudinally.

Methods: 144 consecutive treatment-naïve early RA patients (<12 months symptoms duration) underwent ultrasound-guided synovial biopsy before and 6 months after disease-modifying antirheumatic drug (DMARD) initiation. Synovial biopsies were analysed for cellular (immunohistology) and molecular (NanoString) characteristics and results compared with clinical and imaging outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2018-214539DOI Listing

The rheumatoid hand in the light of fluorescence: a diagnostic technique of the future?

Reumatologia 2019 28;57(1):45-49. Epub 2019 Feb 28.

Department of Rheumatology and Connective Tissue Diseases, Dr. Jan Biziel University Hospital No. 2 in Bydgoszcz, Poland.

Fluorescence spectroscopy is usually applied in physics, chemistry and related sciences. However, in recent years we can observe a growing interest in fluorescence spectroscopy for medical diagnostics. Currently, it is beginning to be used in the monitoring of rheumatoid arthritis (RA) activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/reum.2019.83239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409828PMC
February 2019

Oral and Subcutaneous Administration of a Near-Infrared Fluorescent Molecular Imaging Agent Detects Inflammation in a Mouse Model of Rheumatoid Arthritis.

Sci Rep 2019 Mar 12;9(1):4661. Epub 2019 Mar 12.

Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48109, United States.

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes irreversible damage to the joints. However, effective drugs exist that can stop disease progression, leading to intense interest in early detection and treatment monitoring to improve patient outcomes. Imaging approaches have the potential for early detection, but current methods lack sensitivity and/or are time-consuming and expensive. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-019-38548-0
Publisher Site
http://dx.doi.org/10.1038/s41598-019-38548-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411963PMC
March 2019
2 Reads

Detection of rheumatoid arthritis from hand radiographs using a convolutional neural network.

Clin Rheumatol 2019 Mar 8. Epub 2019 Mar 8.

Department of Computer Engineering, Faculty of Engineering, Çankaya University, Ankara, Turkey.

Introduction: Plain hand radiographs are the first-line and most commonly used imaging methods for diagnosis or differential diagnosis of rheumatoid arthritis (RA) and for monitoring disease activity. In this study, we used plain hand radiographs and tried to develop an automated diagnostic method using the convolutional neural networks to help physicians while diagnosing rheumatoid arthritis.

Methods: A convolutional neural network (CNN) is a deep learning method based on a multilayer neural network structure. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10067-019-04487-4
Publisher Site
http://dx.doi.org/10.1007/s10067-019-04487-4DOI Listing
March 2019
7 Reads

Correlation between systemic osteoporosis and local bone erosion with rheumatoid arthritis patients in Chinese population.

Rheumatology (Oxford) 2019 Mar 7. Epub 2019 Mar 7.

Institute of Clinical pharmacology, Anhui Medical University.

Objective: RA is a systemic auto-immune inflammatory disease that can lead to local bone erosions and generalized osteoporosis (OP). The aim of this study was to investigate the relationship between systemic osteoporosis and local bone erosion with RA patients in the Chinese population.

Methods: In total, 1235 patients with RA and 158 normal subjects were enrolled in this study. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/rheumatology/advance-article/doi/10
Publisher Site
http://dx.doi.org/10.1093/rheumatology/kez042DOI Listing
March 2019
4 Reads

Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder.

Gene 2019 May 27;698:41-49. Epub 2019 Feb 27.

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

Matrix metalloproteinases (MMPs) play a key role in several diseases such as rheumatoid arthritis, HIV-associated neurological diseases (HAND), multiple sclerosis, osteoporosis, stroke, Alzheimer's disease, certain viral infections of the central nervous system, cancer, and hepatitis C virus. MMPs have been explained with regards to extracellular matrix remodeling, which occurs throughout life and ranges from tissue morphogenesis to wound healing in various processes. MMP are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.02.057DOI Listing
May 2019
3 Reads

Erosive rheumatoid arthritis in a young patient with mirror hand.

BMJ Case Rep 2019 Feb 28;12(2). Epub 2019 Feb 28.

Rheumatology, Queen Alexandra Hospital, Portsmouth, UK.

Mirror hand is a congenital anomaly characterised by duplication of the ulnar ray, resulting in polydactyly and functional disability of the hand. It can cause arthralgias and weakness in intrinsic muscles of the hand. We present a young woman who had a surgically corrected mirror hand and subsequently developed aggressive rheumatoid arthritis, which increased her limitations to a significant degree. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22773
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-227739DOI Listing
February 2019
5 Reads

'Carpal tunnel syndrome' and 'tennis elbow' as prodromes for granulomatosis with polyangiitis (formerly Wegener's granulomatosis).

BMJ Case Rep 2019 Feb 28;12(2). Epub 2019 Feb 28.

Division of Rheumatology, Columbia University, New York, New York, USA.

A 62-year-old man presented with excruciating joint pains, back stiffness and numbness of his hands and feet. Over the past 18 months, he had experienced similar episodes for which the diagnoses of bilateral carpal tunnel syndrome and lateral epicondylitis had been made. Physical examination revealed polyarticular arthritis affecting the shoulders, wrists and right knee. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227348DOI Listing
February 2019
2 Reads

Hydroxychloroquine-induced inverse psoriasis.

BMJ Case Rep 2019 Feb 28;12(2). Epub 2019 Feb 28.

Altoona Arthritis and Osteoporosis Center/Altoona Center for Clinical Research, Ducansville, Pennsylvania, USA.

A 65-year-old woman presented to our rheumatology clinic with pain and swelling of multiple joints of her hands. After a thorough evaluation, she was diagnosed with rheumatoid arthritis and was started on hydroxychloroquine therapy. A week later, she presented to our clinic with an acute condition and reported that after taking hydroxychloroquine for a few days she developed multiple rashes, most prominent at skin folds around her breasts, neck, axillae and buttocks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-224619DOI Listing
February 2019
1 Read

Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways.

J Cell Physiol 2019 Feb 27. Epub 2019 Feb 27.

Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China.

Aseptic prosthetic loosening and periprosthetic infection resulting in inflammatory osteolysis is a leading complication of total joint arthroplasty (TJA). Excessive bone destruction around the bone and prosthesis interface plays a key role in the loosening prostheses leading to revision surgery. The bacterial endotoxins or implant-derived wear particles-induced inflammatory response is the major cause of the elevated osteoclast formation and activity. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jcp.28408
Publisher Site
http://dx.doi.org/10.1002/jcp.28408DOI Listing
February 2019
18 Reads
3.839 Impact Factor

Hand, foot, and spine deformities in parkinsonian disorders.

J Neural Transm (Vienna) 2019 Mar 27;126(3):253-264. Epub 2019 Feb 27.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 7200 Cambridge St, Suite #9A, Houston, TX, 77030, USA.

Hand and foot deformities, known as "striatal deformities", and other musculoskeletal abnormalities such as dropped head, bent spine, camptocormia, scoliosis and Pisa syndrome, are poorly understood and often misdiagnosed features of Parkinson's disease and other parkinsonian syndromes. These deformities share some similarities with known rheumatologic conditions and can be wrongly diagnosed as rheumatoid arthritis, osteoarthritis, psoriatic arthritis, Dupuytren's contracture, trigger finger, or other rheumatologic or orthopedic conditions. Neurologists, rheumatologists, and other physicians must be familiar with these deformities to prevent misdiagnosis and unnecessary diagnostic tests, and to recommend appropriate treatment options. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-019-01986-1DOI Listing
March 2019
3 Reads

MR and ultrasound of the hands and wrists in rheumatoid arthritis. Part II. Added clinical value.

Authors:
David A Rubin

Skeletal Radiol 2019 Feb 26. Epub 2019 Feb 26.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO, 63110, USA.

Advanced imaging has become just as vital for diagnosing, staging, and monitoring disease in rheumatoid arthritis (RA) patients as it is for cancer patients. Part 1 of this review discussed synovitis, tenosynovitis, erosions, and osteitis-key imaging findings that occur in patients with RA. Part 2 will now show how these features, in combination with clinical and serologic data, can assist clinical decision-making at various stages of a patient's disease course. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00256-019-03180-6
Publisher Site
http://dx.doi.org/10.1007/s00256-019-03180-6DOI Listing
February 2019
4 Reads

Estimation of drug effect in radiographic progression for rheumatoid arthritis and psoriatic arthritis.

Pharm Stat 2019 Feb 26. Epub 2019 Feb 26.

Statistical Methodology and Modeling Group, Janssen Research & Development, Spring House, Pennsylvania.

To demonstrate the treatment effect on structural damage in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), radiographic images of hands and feet are scored according to Sharp scoring systems in randomized clinical trials. However, the quantification of such an effect is challenging because the overall mean progression is lack of clinical interpretation. This article attempts to shed a light on the statistical challenges resulted from its scoring methods and heterogeneity of the study population and proposes a mixture distribution model approach to fit radiographic progression data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pst.1936DOI Listing
February 2019
2 Reads

Anti-nuclear antibody development is associated with poor treatment response to biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis.

Semin Arthritis Rheum 2019 Feb 10. Epub 2019 Feb 10.

Center for Investigative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Clinical Research Center, Shizuoka General Hospital, Shizuoka 420-0881, Japan; Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan. Electronic address:

Background: It has been well known that TNF-α inhibitor (TNFi) treatment for patients with rheumatoid arthritis (RA) is associated with anti-nuclear antibody (ANA) development. We previously reported that ANA development was associated with poor outcomes of infliximab (IFX) treatment (1). However, no replication studies have been reported to date. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semarthrit.2019.02.003DOI Listing
February 2019
1 Read

MRI and ultrasound of the hands and wrists in rheumatoid arthritis. I. Imaging findings.

Authors:
David A Rubin

Skeletal Radiol 2019 May 23;48(5):677-695. Epub 2019 Feb 23.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO, 63110, USA.

The management of patients with rheumatoid arthritis (RA) has rapidly evolved with the development of newer disease-modifying drugs and the recognition that long-term damage can be mitigated by an earlier and more-informed use of these medications. Historically, radiographs were the mainstay of imaging in RA patients, but radiographic joint narrowing and erosions are late and insensitive findings in the disease. MRI (with intravenous contrast agent) and ultrasound (with power Doppler interrogation) of the hands and wrists are able to demonstrate erosions earlier and with greater sensitivity than radiographs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00256-019-03179-zDOI Listing
May 2019
1 Read

Pachydermoperiostosis (Touraine-Solente-Gole syndrome): a case report.

J Med Case Rep 2019 Feb 21;13(1):39. Epub 2019 Feb 21.

Tribhuvan University Institute of Medicine, Maharajgunj, Kathmandu, Nepal.

Background: Pachydermoperiostosis (PDP) is a rare disorder characterized by clubbing of the fingers, thickening of the skin (pachyderma), and excessive sweating (hyperhidrosis). It typically appears during childhood or adolescence, often around the time of puberty, and progresses slowly. Clinical presentations of PDP can be confused with secondary hypertrophic osteoarthropathy, psoriatic arthritis, rheumatoid arthritis, thyroid acropachy, and acromegaly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-018-1961-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383214PMC
February 2019
1 Read

Chronic heart failure patients' experiences of German healthcare services: a protocol for a scoping review.

BMJ Open 2019 Feb 19;9(2):e025685. Epub 2019 Feb 19.

Institute of General Practice, Goethe University Frankfurt, Frankfurt, Germany.

Introduction: Chronic heart failure (CHF) is a heterogeneous condition requiring complex treatment from diverse healthcare services. An increasingly holistic understanding of healthcare has resulted in contextual factors such as perceived quality of care, as well as patients' acceptance, preferences and subjective expectations of health services, all gaining in importance. How patients with CHF experience the use of healthcare services has not been studied within the scope of a systematic review in a German healthcare context. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377537PMC
February 2019
1 Read

LIFE QUALITY EVALUATION USING "TIME TRADE OFF" METHOD FOR RHEUMATOID HANDS.

Acta Ortop Bras 2018 ;26(6):374-378

Hand and Microsurgery Group, Institute of Orthopedics and Traumatology Medical School, Universidade de Sao Paulo, Hospital das Clinicas HCFMUSP, Sao Paulo, SP, Brazil.

Objective: Rheumatoid arthritis is a prevalent disease in the population (range 0.5% to 1%) and involves both orthopedic and rheumatologic treatment. The Time Trade-Off (TTO) technique, which determines the number of years the patient or the professional would be allowed before a successful procedure in terms of life expectancy and value of the procedure, has been gaining ground in clinical protocols. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1413-785220182606199308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362677PMC
January 2018

Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, and the Department of Medicine, Division of Rheumatology, and the School of Pharmacy, at the University of California, San Francisco (UCSF), San Francisco, California; Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, Ohio; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by UCB Pharmaceutical Inc. (Xiaojuan Li). T. Shimizu, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; A. Cruz, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, and School of Pharmacy, UCSF; M. Tanaka, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; K. Mamoto, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Biomedical Engineering, PAMI, Cleveland Clinic; V. Pedoia, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; A.J. Burghardt, BS, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; U. Heilmeier, MD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; T.M. Link, MD, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF; J. Graf, MD, Department of Medicine, Division of Rheumatology, UCSF; J.B. Imboden, MD, Department of Medicine, Division of Rheumatology, UCSF; X. Li, PhD, Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, and Department of Biomedical Engineering, PAMI, Cleveland Clinic. Address correspondence to Dr. T. Shimizu, Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. E-mail: Accepted for publication October 24, 2018.

Objective: To investigate the correlation between changes in radiological quantitative assessment with changes in clinical and functional assessment from baseline to 3 months in patients with rheumatoid arthritis (RA).

Methods: Twenty-eight patients with RA [methotrexate (MTX) and anti-tumor necrosis factor-α (TNF-α) group with high disease activity (n = 18); and MTX group with low disease activity (n = 10)] underwent assessments at baseline and 3 months: clinical [28-joint count Disease Activity Score (DAS28)], functional [Health Assessment Questionnaire (HAQ) and Michigan Hand Outcome Questionnaire (MHQ)], and imaging-based [3 Tesla magnetic resonance imaging (MRI) and high-resolution peripheral quantitative computed tomography (HR-pQCT)]. MR images were evaluated semiquantitatively [RA MRI scoring (RAMRIS)] and quantitatively for the volume of synovitis and bone marrow edema (BME) lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.180496DOI Listing
February 2019
1 Read

Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan.

Objectives: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) inflamed joints. In the current study we investigated the role of the neutrophil-derived lactoferrin (LTF), as an endogenous ligand for TLR4 in the inflammatory response of RA synovial fibroblasts (RASFs).

Methods: RASFs were stimulated with LTF, and the expressions of inflammatory cytokines in RASFs were measured. Read More

View Article

Download full-text PDF

Source
February 2019
2 Reads

IL-17 and limits of success.

Cell Immunol 2018 Sep 17. Epub 2018 Sep 17.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address:

Interleukin-17 (IL-17) is a potent proinflammatory cytokine that protects a host against fungal and extracellular bacterial infections. On the other hand, excessive or dysregulated production of IL-17 underlines susceptibility to autoimmune disease. Consequently, blocking IL-17 has become an effective strategy for modulating several autoimmune diseases, including multiple sclerosis (MS), psoriasis, and rheumatoid arthritis (RA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellimm.2018.09.001DOI Listing
September 2018
3 Reads
1.924 Impact Factor

What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?

Arthritis Res Ther 2019 Feb 14;21(1):56. Epub 2019 Feb 14.

Department of Rheumatology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

Background: MRI-detected subclinical joint inflammation in the hand joints of patients with undifferentiated arthritis (UA) predicts progression to rheumatoid arthritis (RA). It is unknown if adding MRI of the foot increases predictive accuracy compared to the hand alone.

Methods: 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13075-019-1845-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376768PMC
February 2019
1 Read

Seropositive Rheumatoid Arthritis with Very Unusual X-ray Findings.

Eur J Case Rep Intern Med 2018 26;5(7):000883. Epub 2018 Jul 26.

Rheumatology Department, Hamad General Hospital, Doha, Qatar.

We described the case of a 23-year-old Nepalese man with seropositive rheumatoid arthritis and abnormal x-ray findings, found to be due to a very rare bone disease: Camurati Engelmann disease or progressive diaphyseal dysplasia (PDD). This is the first case reported in the Gulf area, although approximately 300 cases have been described worldwide. These patients usually present with limb pain and easy fatigability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346779PMC
July 2018
1 Read

Hand grip endurance moderating the effect of grip force on functional ability and disease activity in rheumatoid arthritis patients: a cross-sectional study.

Rheumatol Int 2019 Apr 12;39(4):647-656. Epub 2019 Feb 12.

University Department of Rheumatology, Physical and Rehabilitation Medicine, Clinical Hospital Centre Sestre milosrdnice, Vinogradska 29, HR-10.000, Zagreb, Croatia.

To examine the effect of endurance on the relationship between grip force and measures of functional capacity and disease activity, we performed a cross-sectional study at the University Department of Rheumatology, Physical medicine and Rehabilitation from January 2017 to August 2018. Functional capacity of the hand was measured by ABILHAND-RA questionnaire and disease activity was assessed by the Disease Activity Score (DAS-28-CRP). All participants underwent dynamometric measurements of maximal grip force and hand grip endurance during repeated gripping. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-019-04250-7DOI Listing
April 2019
1 Read

An integrated proteomic and glycoproteomic study for differences on glycosylation occupancy in rheumatoid arthritis.

Anal Bioanal Chem 2019 Mar 7;411(7):1331-1338. Epub 2019 Feb 7.

Center for Diagnostics & Therapeutics and Department of Chemistry, Georgia State University, 50 Decatur St SE, Atlanta, GA, 30303, USA.

Rheumatoid arthritis (RA) is an autoimmune disease in which certain immune cells are dysfunctional and attack their own healthy tissues. There has been great difficulty in finding an accurate and efficient method for the diagnosis of early-stage RA. The present shortage of diagnostic methods leads to the rough treatments of the patients in the late stages, such as joint removing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00216-018-1543-3DOI Listing
March 2019
7 Reads

US-Guided Biopsies: Overarching Principles.

Front Med (Lausanne) 2019 22;6. Epub 2019 Jan 22.

Department of Rheumatology, Université de Genève, Geneva, Switzerland.

Gathering synovial tissue from any swollen joint especially in early arthritis patients is critical for good quality research and to obtain further insight into the pathophysiology of inflammatory joint diseases. Multiplying biopsy sites is a challenge in terms of the techniques needed for each different joint but also in terms of safety and tolerability. It is important to provide the best care especially in very early arthritis patients who have only had the disease for a few months. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fmed.2019.00001/
Publisher Site
http://dx.doi.org/10.3389/fmed.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349745PMC
January 2019
6 Reads

Survival Rate on a 10-Year Follow-Up of Total Wrist Replacement Implants: A 23-Patient Case Series.

J Wrist Surg 2019 Feb 7;8(1):24-29. Epub 2018 Aug 7.

Department of Hand Surgery, SOS main, CCOM, University Hospital of Strasbourg, FMTS, University of Strasbourg, Illkirch, France.

 According to current literature, the estimated average survival rate for Remotion, the total wrist implants, is above 90% on an 8-year follow-up. We examined our series of Remotion to calculate its survival rate on a 10-year follow-up.  A total of 23 cases of total wrist implants were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1668152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358454PMC
February 2019
3 Reads

Ultrasonographic criteria for the diagnosis of erosive rheumatoid arthritis using osteoarthritic patients as controls compared to validated radiographic criteria.

Joint Bone Spine 2019 Jan 31. Epub 2019 Jan 31.

Department of rheumatology, university hospital of Nancy, 54500 Vandoeuvre-lès-Nancy, France; Inserm, CIC-EC CIE6, university hospital of Nancy, epidemiology and clinical evaluation, 54500 Vandoeuvre-lès-Nancy, France.

Objectives: The aims of this study were to compare characteristics of radiography (RX) and ultrasound (US) erosive lesions in rheumatoid arthritis (RA) and osteoarthritis (OA) patients (prevalence, topography and severity), to determine thresholds for the diagnosis of erosive RA based on US and to evaluate the performance of US and RX to establish a diagnosis of erosive RA differentiated from hand OA.

Methods: Patients fulfilling ACR 1987 and/or ACR/EULAR 2010 criteria for RA or ACR hand OA criteria were prospectively included. A modified Sharp erosion score was assessed by two blinded readers and one adjudicator for discordant cases (number of eroded joints ≤ three). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbspin.2019.01.011DOI Listing
January 2019
2 Reads

The Multifaceted S100A4 Protein in Cancer and Inflammation.

Methods Mol Biol 2019 ;1929:339-365

Faculty of Health, Department of Neuroscience, Copenhagen University, Copenhagen, Denmark.

The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been discovered as a potent factor implicated in various inflammation-associated diseases. S100A4 is involved in a range of biological functions such as angiogenesis, cell differentiation, apoptosis, motility, and invasion. Moreover, S100A4 is also a potent trigger of inflammatory processes and induces the release of cytokines and growth factors under different pathological conditions. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4939-9030-6_22
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-9030-6_22DOI Listing
January 2019
10 Reads

Repair of Erosions in Patients with Rheumatoid Arthritis.

J Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

From Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology, Lund; Department of Research and Education, Skånevård Sund, Region Skåne, Helsingborg´s Hospital, Helsingborg, Sweden. This study was supported by grants from the Swedish Rheumatism Association, and the Foundation for Assistance to Disabled People in Skåne (Stiftelsen för Bistånd åt Rörelsehindrade i Skåne). K. Forslind, Associate Professor, Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology, and the Department of Research and Education, Skånevård Sund, Region Skåne, Helsingborg's Hospital; K. Eberhardt, Associate Professor, Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology; B. Svensson, Associate Professor, Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Rheumatology. Address correspondence to K. Forslind, Department of Research and Education, Skånevård Sund, Region Skåne, Helsingborg's Hospital, 25187 Helsingborg, Sweden. E-mail: Accepted for publication October 16, 2018.

Objective: The aim of this study was to examine the occurrence of repair in a cohort of conventionally treated patients with early rheumatoid arthritis over 8 years.

Methods: There were 395 patients included in the BARFOT study having radiographs of hands and feet at inclusion, and at 1, 2, 5, and 8 years, which were chronologically scored for erosions by the Sharp/van der Heijde method. An erosion with repair was defined as an erosion that has become partially or totally filled, with or without sclerosis. Read More

View Article

Download full-text PDF

Source
http://www.jrheum.org/lookup/doi/10.3899/jrheum.180557
Publisher Site
http://dx.doi.org/10.3899/jrheum.180557DOI Listing
February 2019
8 Reads

Intravoxel incoherent motion MRI for discrimination of synovial proliferation in the hand arthritis: A prospective proof-of-concept study.

J Magn Reson Imaging 2019 Jan 31. Epub 2019 Jan 31.

Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Background: Postcontrast-enhanced MRI is currently the reference standard for synovial proliferation in rheumatoid arthritis (RA). However, the technique is somewhat invasive due to the use of gadolinium contrast agents, which may cause severe adverse/side effects. Intravoxel incoherent motion (IVIM) simultaneously permits quantification of perfusion as well as diffusion using a single imaging scan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmri.26660DOI Listing
January 2019