142,498 results match your criteria Rheumatoid Arthritis


Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects.

Int Immunopharmacol 2019 Apr 17;72:292-300. Epub 2019 Apr 17.

Department of Immunology, Medical College of Nanchang University, Nanchang 330000, China. Electronic address:

Curcumin is a natural herbal product that has been popularly used to treat autoimmune diseases in China; however, its effects on rheumatoid arthritis and its mechanism are not clear. The main purposes of this study are to explore the therapeutic effects of curcumin on collagen-induced arthritis (CIA) rats and the pharmacological mechanism. In the present study, CIA rats were established by injecting bovine type II collagen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193079
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http://dx.doi.org/10.1016/j.intimp.2019.04.027DOI Listing
April 2019
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Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.

Matrix Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Virginia, Charlottesville, VA, USA. Electronic address:

The extracellular matrix (ECM) microenvironment is increasingly implicated in the instruction of pathologically relevant cell behaviors, from aberrant transdifferentation to invasion and beyond. Indeed, pathologic ECMs possess a panoply of alterations that provide deleterious instructions to resident cells. Here we demonstrate the precise manner in which the ECM protein fibronectin (FN) undergoes the posttranslational modification citrullination in response to peptidyl-arginine deiminase (PAD), an enzyme associated with innate immune cell activity and implicated in systemic ECM-centric diseases, like cancer, fibrosis and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/j.matbio.2019.04.002DOI Listing

Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, China. Electronic address:

Rheumatoid arthritis fibroblast-like synoviocytes play an essential role in the occurrence and progression of rheumatoid arthritis. As the main pharmacologically active components of Aralia taibaiensis, total saponins, particularly triterpenoid saponins, have been shown to possess multiple pharmacological activities including relieving rheumatism. However, the effect of araloside A, a triterpenoid saponin extracted from the root bark of Aralia taibaiensis, on rheumatoid arthritis remains unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.025DOI Listing

Economic Evaluation of Sarilumab in the Treatment of Adult Patients with Moderately-to-Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Nebraska Medical Center, Omaha, NE, USA.

Introduction: Assess the cost-effectiveness (US healthcare payer perspective) of sarilumab subcutaneous (SC) 200 mg + methotrexate versus conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) or targeted DMARD + methotrexate for moderate-to-severe rheumatoid arthritis (RA) in adults with inadequate response to methotrexate.

Methods: Microsimulation based on patient profiles from MOBILITY (NCT01061736) was conducted via a 6-month decision tree and lifetime Markov model with 6-monthly cycles. Treatment response at 6 months was informed by a network meta-analysis and based on American College of Rheumatology (ACR) response. Read More

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http://dx.doi.org/10.1007/s12325-019-00946-1DOI Listing

Oral health-related quality of life among individuals with rheumatoid arthritis.

Clin Rheumatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Oral Pathology and Surgery, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Objective: To evaluate the oral health-related quality of life (OHRQoL) of individuals with rheumatoid arthritis (RA) in comparison with individuals with no RA.

Method: A cross-sectional study was carried out with 112 individuals distributed into two groups. Group 1 (G1) consisted of 42 RA individuals and group 2 (G2) consisted of 70 individuals without RA. Read More

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http://link.springer.com/10.1007/s10067-019-04555-9
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http://dx.doi.org/10.1007/s10067-019-04555-9DOI Listing
April 2019
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A constitutional activating MET mutation makes the genetic link between malignancies and chronic inflammatory diseases.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Inserm U1165, University Paris 7.

Purpose: The genesis of all cancers results from an accumulation of mutations, constitutional and/or acquired when induced by external mutagenic factors. High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic changes.

Experimental Design: Here, we proposed an innovative individual approach by studying tissue samples from a young woman with an unusual association of breast cancer, polycythemia vera and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3261DOI Listing

Factors Associated With Bone Density Monitoring While on Antiosteoporosis Treatment in Routine Clinical Practice: A Registry-Based Cohort Study.

J Clin Densitom 2019 Mar 21. Epub 2019 Mar 21.

Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

The role for bone mineral density (BMD) monitoring while on antiosteoporosis therapy remains controversial. The current study used population-based registries to identify factors associated with BMD monitoring in women within 5 yr of receiving antiosteoporosis treatment vs treatment without monitoring in routine clinical practice. The analytical dataset consisted of women age 40 yr and older at baseline receiving antiosteoporosis therapy: 6877 with BMD monitoring (mean interval 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10946950193003
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http://dx.doi.org/10.1016/j.jocd.2019.03.006DOI Listing
March 2019
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Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid Arthritis.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

The Engineering Research Center of Synthetic Polypeptide Drug Discovery and Evaluation of Jiangsu Province, China Pharmaceutical University, Nanjing 210009, China.

ανβ3 and α5β1 are essential glycoproteins involved in the pathogenesis of rheumatoid arthritis (RA). Understanding of the role these integrins play in disease have been analyzed via description of cells-expressing ανβ3 and α5β1 and their mediators to trigger inflammation. ανβ3 and α5β1 facilitate cells-ECM and cell-cell communication, producing pro-inflammatory factors. Read More

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https://www.mdpi.com/1420-3049/24/8/1537
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http://dx.doi.org/10.3390/molecules24081537DOI Listing
April 2019
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Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139 Florence, Italy.

To study new target-oriented molecules that are active against rheumatoid arthritis-dependent pain, new dual inhibitors incorporating both a carbonic anhydrase (CA)-binding moiety and a cyclooxygenase inhibitor (NSAID) were tested in a rat model of rheumatoid arthritis induced by CFA intra-articular (i.a.) injection. Read More

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http://dx.doi.org/10.3390/ijms20081923DOI Listing

Prevalence and predictors for sustained remission in rheumatoid arthritis.

PLoS One 2019 19;14(4):e0214981. Epub 2019 Apr 19.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea.

Objective: Remission is a key goal in managing rheumatoid arthritis (RA), with sustained remission as the preferred sequelae of short-term remission. However little is known about the predictors of sustained remission for patients reaching remission. Using two independent cohorts, we aimed to evaluate the prevalence and predictors for sustained remission. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214981PLOS
April 2019
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GdX/UBL4A-knockout mice resist collagen-induced arthritis by balancing the population of T1/T17 and regulatory T cells.

FASEB J 2019 Apr 19:fj201802217RR. Epub 2019 Apr 19.

State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.

Rheumatoid arthritis (RA) is an autoimmune disease associated with synovial hyperplasia and bone and cartilage destruction. T cells, notably T helper (T)-1 and T17 cells, play a critical role in the pathologic process of RA. However, it remains unclear how T1 and T17 cells are regulated during RA. Read More

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http://dx.doi.org/10.1096/fj.201802217RRDOI Listing

Abatacept alleviates rheumatoid arthritis development by inhibiting migration of fibroblast-like synoviocytes via MAPK pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3105-3111

Department of Rheumatology, Yantaishan Hospital, Yantai, China.

Objective: To investigate whether Abatacept could regulate the occurrence and progression of rheumatoid arthritis (RA) by mediating cell migration of fibroblast-like synoviocytes (FLS) via mitogen-activated protein kinase (MAPK) pathway.

Patients And Methods: Levels of MMP1, MMP3 and MMP13 in RA-FLS treated with Abatacept or MAPK pathway inhibitor were detected by quantitative Real-time-polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The regulatory effect of Abatacept on MAPK pathway was detected by Western blot. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17594DOI Listing

Moderate-to-severe psoriasis and pregnancy: impact on fertility, pregnancy outcome and treatment perspectives.

G Ital Dermatol Venereol 2019 Jun;154(3):305-314

Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Psoriasis affects 2-4% of the world's population, with no difference between men and women and 70% of patients experiencing disease onset before the age of 40, which coincides with the reproductive years. Few data are available from literature on impact of psoriasis on fertility, course and outcome of pregnancy and risk associated with treatments. Recent studies on other immune-mediated inflammatory diseases, among which psoriasis is also included, indicate that rheumatoid arthritis and inflammatory bowel diseases can impact female fertility and pregnancy outcomes especially during active disease episodes. Read More

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https://www.minervamedica.it/index2.php?show=R23Y2019N03A030
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http://dx.doi.org/10.23736/S0392-0488.18.06255-7DOI Listing
June 2019
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[Tight control-Demand for short term control of rheumatoid arthritis].

Z Rheumatol 2019 Apr 18. Epub 2019 Apr 18.

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

The prognosis of rheumatoid arthritis (RA) has been significantly improved in recent decades. This is mainly due to earlier detection, better diagnostics and new treatment options, such as the optimized use of classical disease-modifying antirheumatic drugs (DMARD) and biologicals. Other factors involved were earlier intervention, improved availability of information and analyses and certainly also standardization of care (e. Read More

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http://link.springer.com/10.1007/s00393-019-0631-x
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http://dx.doi.org/10.1007/s00393-019-0631-xDOI Listing
April 2019
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Concordance between the Different Cardiovascular Risk Scores in People with Rheumatoid Arthritis and Psoriasis Arthritis.

Cardiol Res Pract 2019 14;2019:7689208. Epub 2019 Mar 14.

Clinical Epidemiology and Biostatistics Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña, Hotel de Pacientes 7 Planta, C/As Xubias de Arriba, 84, 15006 A Coruña, Spain.

Aim: To determine the cardiovascular risk and the concordance between the different scores in people with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).

Methods: Observational descriptive study of prevalence. Performed in the Rheumatology Service and the Clinical Epidemiology and Biostatistics Unit of the University Hospital Complex of A Coruña (Spain). Read More

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http://dx.doi.org/10.1155/2019/7689208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437736PMC

Intra- and Inter-observer Variability in Different Methods of Measuring Carpal Collapse.

Malays Orthop J 2019 Mar;13(1):20-24

Department of Hand Surgery, Ganga Hospital, Coimbatore, India.

Carpal collapse of wrist occurs in disorders like rheumatoid arthritis and Kienbock's disease. Three techniques have been described to measure carpal collapse. First, the carpal height ratio (CHR), measured by dividing carpal height by 3rd metacarpal length. Read More

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http://www.morthoj.org/2019/v13n1/measuring-carpal-collapse.
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http://dx.doi.org/10.5704/MOJ.1903.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459038PMC
March 2019
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Simiao Pill Attenuates Collagen-Induced Arthritis in Rats through Suppressing the ATX-LPA and MAPK Signalling Pathways.

Evid Based Complement Alternat Med 2019 14;2019:7498527. Epub 2019 Mar 14.

Department of Integrated Chinese Traditional and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430070, China.

Objective: Simiao pill (SM), a traditional Chinese formula, has been used as an antirheumatic drug in clinical practice for hundreds of years. Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and hyperplasia, cartilage destruction, and joint damage. This study was designed to investigate the protective effects of SM on collagen-induced arthritis (CIA) in rats. Read More

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http://dx.doi.org/10.1155/2019/7498527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437962PMC

Osteoimmunology of Bone Loss in Inflammatory Rheumatic Diseases.

Front Immunol 2019 3;10:679. Epub 2019 Apr 3.

INSERM, UMR1033 LYOS, Lyon, France.

Over the past two decades, the field of osteoimmunology has emerged in response to a range of evidence demonstrating the reciprocal relationship between the immune system and bone. In particular, localized bone loss, in the form of joint erosions and periarticular osteopenia, as well as systemic osteoporosis, caused by inflammatory rheumatic diseases including rheumatoid arthritis, the prototype of inflammatory arthritis has highlighted the importance of this interplay. Osteoclast-mediated resorption at the interface between synovium and bone is responsible for the joint erosion seen in patients suffering from inflammatory arthritis. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00679
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http://dx.doi.org/10.3389/fimmu.2019.00679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456657PMC
April 2019
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Feto-Maternal Microchimerism: The Pre-eclampsia Conundrum.

Front Immunol 2019 29;10:659. Epub 2019 Mar 29.

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Feto-maternal microchimerism (FMM) involves bidirectional cross-placental trafficking during pregnancy, leading to a micro-chimeric state that can persist for decades. In this manner a pregnant woman will harbor cells from her mother, as well as, cells from her child. Historically, eclampsia, a severe disorder of pregnancy provided the basis for FMM following the detection of trophoblast cells in the lungs of deceased women. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00659
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http://dx.doi.org/10.3389/fimmu.2019.00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455070PMC
March 2019
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Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner.

Front Immunol 2019 2;10:633. Epub 2019 Apr 2.

Department of Immune Modulation, Universitätsklinikum Erlangen, Erlangen, Germany.

Interference with autoimmune-mediated cytokine production is a key yet poorly developed approach to treat autoimmune and inflammatory diseases such as rheumatoid arthritis. Herein, we show that soluble CD83 (sCD83) enhances the resolution of autoimmune antigen-induced arthritis (AIA) by strongly reducing the expression levels of cytokines such as IL-17A, IFNγ, IL-6, and TNFα within the joints. Noteworthy, also the expression of RANKL, osteoclast differentiation, and joint destruction was significantly inhibited by sCD83. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00633
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http://dx.doi.org/10.3389/fimmu.2019.00633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455294PMC
April 2019
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The IL-23/IL-17 pathway in human chronic inflammatory diseases-new insight from genetics and targeted therapies.

Genes Immun 2019 Apr 19. Epub 2019 Apr 19.

Immunoregulation Unit, Department of Immunology, Institut Pasteur, Paris, France.

Chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, spondyloarthritis, and psoriasis cause significant morbidity and are a considerable burden for the patients in terms of pain, impaired function, and diminished quality of life, as well as for society, because of the associated high health-care costs and loss of productivity. Our limited understanding of the pathogenic mechanisms involved in these diseases currently hinders early diagnosis and the development of more specific and effective therapies. The past years have been marked by considerable progress in our insight of the genetic basis of many diseases. Read More

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http://www.nature.com/articles/s41435-019-0067-y
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http://dx.doi.org/10.1038/s41435-019-0067-yDOI Listing
April 2019
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Advances in the pathogenesis and treatment of autoimmunity.

Authors:
Kamal D Moudgil

Cell Immunol 2019 Apr 8. Epub 2019 Apr 8.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Department of Medicine, Division of Rheumatology, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Baltimore VA Medical Center, Baltimore, MD 21201, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00088749193013
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http://dx.doi.org/10.1016/j.cellimm.2019.04.005DOI Listing
April 2019
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Novel optical spectral transmission (OST)-guided versus conventionally disease activity-guided treatment: study protocol of a randomized clinical trial on guidance of a treat-to-target strategy for early rheumatoid arthritis.

Trials 2019 Apr 17;20(1):226. Epub 2019 Apr 17.

Rheumatology & Clinical Immunology, University Medical Center Utrecht, G02.230, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.

Background: Assessment of disease activity is a critical component of tight-control, treat-to-target treatment strategies of rheumatoid arthritis (RA). Recently, the HandScan has been validated as a novel method for objectively assessing RA disease activity in only 1.5 min, using optical spectral transmission (OST) in hands and wrists. Read More

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http://dx.doi.org/10.1186/s13063-019-3285-8DOI Listing

Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy.

Arthritis Res Ther 2019 Apr 18;21(1):102. Epub 2019 Apr 18.

Eli Lilly and Company, Indianapolis, IN, USA.

Background: Clinical guidelines recommend pneumococcal and tetanus vaccinations in patients with rheumatoid arthritis (RA). Baricitinib is an oral, selective Janus kinase (JAK) 1/JAK 2 inhibitor and is approved for the treatment of moderately to severely active RA in adults in over 50 countries including European countries, the USA, and Japan. This substudy evaluated pneumococcal conjugate and tetanus toxoid vaccine (TTV) responses in patients with RA receiving baricitinib. Read More

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http://dx.doi.org/10.1186/s13075-019-1883-1DOI Listing

Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial.

Arthritis Res Ther 2019 Apr 18;21(1):101. Epub 2019 Apr 18.

Takeda Development Centre, London, UK.

Background: Namilumab (AMG203), an immunoglobulin G1 monoclonal antibody that binds with high affinity to granulocyte-macrophage colony-stimulating factor (GM-CSF), was evaluated in a phase II randomized, double-blind, placebo-controlled study to investigate the efficacy and safety in patients with rheumatoid arthritis (RA) with an inadequate response to methotrexate (MTX-IR) or anti-tumour necrosis factor therapy (TNF-IR).

Methods: Subcutaneous namilumab (20, 80, or 150 mg) or placebo was administered at baseline and weeks 2, 6, and 10 in patients on stable background methotrexate therapy who were with MTX-IR or TNF-IR. Primary endpoint was mean change from baseline in the 28-joint Disease Activity Score, C-reactive protein version (DAS28-CRP) at week 12 comparing each of the three doses of namilumab to placebo. Read More

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http://dx.doi.org/10.1186/s13075-019-1879-xDOI Listing

Leaves and stems of Capparis erythrocarpos, more sustainable than roots, show antiarthritic effects.

J Ethnopharmacol 2019 Apr 15:111890. Epub 2019 Apr 15.

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Ethnopharmacological Relevance: Capparis erythrocarpos is a medicinal plant used widely in many parts of Africa for the management of pain and inflammatory conditions such as rheumatoid arthritis. Its wide range of use, popularity and high value, make C. erythrocarpos containing products a target for economically driven adulteration. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111890DOI Listing

Physician's Experience and Disease Activity Affect the Impact of Ultrasound on the Treatment Decision in Rheumatoid Arthritis.

J Clin Rheumatol 2019 Apr 12. Epub 2019 Apr 12.

Division of Musculoskeletal and Rheumatic Disorders, Instituto Nacional de Rehabilitación y Ortopedia, Tlalpan, Mexico City, Mexico.

Background/objective: The aim of this cross-sectional study was to explore which factors affect the impact of musculoskeletal ultrasound (MUS) on the treatment proposal among rheumatologists with different grade of experience.

Methods: Sixteen clinical vignettes summarized data from respective rheumatoid arthritis (RA) outpatients; vignettes included clinical evaluation and a blank section for a first treatment proposal; MUS information was then added, based on German Ultrasound score, followed by a blank section for treatment re-consideration, if applicable. During a 6 months period, each vignette was concomitantly presented to six trainees and six senior rheumatologists (SR); three SR had ≥15 years of experience. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001036DOI Listing
April 2019
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Tofacitinib for the treatment of rheumatoid arthritis: an update.

Authors:
Kunihiro Yamaoka

Expert Rev Clin Immunol 2019 Apr 18. Epub 2019 Apr 18.

a Department of Rheumatology and Infectious Diseases , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara , Kanagawa , 252-0374 Japan.

Introduction: Tofacitinib selectively inhibits the Janus kinases, intracellular tyrosine kinases that are activated by cytokines involved in the pathophysiology of rheumatoid arthritis. Areas covered: Clinical trials of tofacitinib have revealed an anti-rheumatic effect of monotherapy and combination therapy with methotrexate (MTX). Post-hoc analysis of those clinical trials and real-world experiences will be reviewed to explore tofacitinib's efficacy and safety. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1607298DOI Listing
April 2019
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LncRNA: An All-rounder in Rheumatoid Arthritis.

J Transl Int Med 2019 Mar 29;7(1):3-9. Epub 2019 Mar 29.

Division of Rheumatology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, Hangzhou, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. Read More

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http://content.sciendo.com/view/journals/jtim/7/1/article-p3
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http://dx.doi.org/10.2478/jtim-2019-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463828PMC
March 2019
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Influence of genetic copy number variants of the human GLUT3 glucose transporter gene on protein expression, glycolysis and rheumatoid arthritis risk: A genetic replication study.

Mol Genet Metab Rep 2019 Jun 6;19:100470. Epub 2019 Apr 6.

Robert S. Boas Center for Genomics and Human Genetics, the Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York, USA.

Objectives: The gene encoding glucose transporter 3 (GLUT3, ) is present in the human population at variable copy number. An overt disease phenotype of copy number variants has not been reported; however, deletion of has been previously reported to protect carriers from rheumatoid arthritis, implicating GLUT3 as a therapeutic target in rheumatoid arthritis. Here we aim to perform functional analysis of GLUT3 copy number variants in immune cells, and test the reported protective association of the GLUT3 copy number variants for rheumatoid arthritis in a genetic replication study. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.100470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453668PMC

Neural networks for automatic scoring of arthritis disease activity on ultrasound images.

RMD Open 2019 30;5(1):e000891. Epub 2019 Mar 30.

Department of Rheumatology, Odense Universitetshospital, Odense, Denmark.

Background: The development of standardised methods for ultrasound (US) scanning and evaluation of synovitis activity by the OMERACT-EULAR Synovitis Scoring (OESS) system is a major step forward in the use of US in the diagnosis and monitoring of patients with inflammatory arthritis. The variation in interpretation of disease activity on US images can affect diagnosis, treatment and outcomes in clinical trials. We, therefore, set out to investigate if we could utilise neural network architecture for the interpretation of disease activity on Doppler US images, using the OESS scoring system. Read More

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2018-00089
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http://dx.doi.org/10.1136/rmdopen-2018-000891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443126PMC
March 2019
1 Read

Randomised, double-blind, phase III study comparing the infliximab biosimilar, PF-06438179/GP1111, with reference infliximab: efficacy, safety and immunogenicity from week 30 to week 54.

RMD Open 2019 28;5(1):e000876. Epub 2019 Mar 28.

Metroplex Clinical Research Center, Dallas, Texas, USA.

Objective: To investigate the efficacy, safety and immunogenicity of PF-06438179/GP1111 (PF-SZ-IFX) compared with European reference infliximab (Remicade; ref-IFX) in patients with moderate-to-severe, active rheumatoid arthritis after continued long-term use of PF-SZ-IFX, and in patients who were switched from ref-IFX to PF-SZ-IFX.

Methods: REFLECTIONS B537-02 was a double-blind, active-controlled, multinational study in which patients (N=650) were initially randomised to PF-SZ-IFX or ref-IFX for 30 weeks (treatment period [TP] 1). During weeks 30-54 (TP2), the PF-SZ-IFX group (n=280) continued treatment with PF-SZ-IFX (PF-SZ-IFX/PF-SZ-IFX) and patients in the ref-IFX group (n=286) were rerandomised (1:1) to continue ref-IFX (ref-IFX/ref-IFX) (n=143) or switch to PF-SZ-IFX (ref-IFX/PF-SZ-IFX) (n=143) for a further 24 weeks. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446180PMC

Re-treatment with abatacept plus methotrexate for disease flare after complete treatment withdrawal in patients with early rheumatoid arthritis: 2-year results from the AVERT study.

RMD Open 2019 8;5(1):e000840. Epub 2019 Feb 8.

Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands.

Objectives: To complete reporting of outcomes after total withdrawal of all rheumatoid arthritis (RA) therapy and re-treatment after flare in Assessing Very Early Rheumatoid arthritis Treatment study (NCT01142726).

Methods: Patients with early RA were initially randomised to double-blind, weekly subcutaneous abatacept plus methotrexate, or abatacept or methotrexate monotherapy. At month 12, patients with Disease Activity Score (DAS)28 C reactive protein (CRP) <3. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446179PMC
February 2019

A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia.

Clin Case Rep 2019 Apr 20;7(4):695-698. Epub 2019 Feb 20.

2nd Department of Dermatology and Venereology, General Hospital "Papageorgiou", Medical School Aristotle University of Thessaloniki Thessaloniki Greece.

Palisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians' goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time. Read More

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http://dx.doi.org/10.1002/ccr3.2072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452460PMC

Studying anemia of chronic disease and iron deficiency in patients with rheumatoid arthritis by iron status and circulating hepcidin.

Hematol Rep 2019 Feb 12;11(1):7708. Epub 2019 Mar 12.

Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq.

Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most important types of anemia in rheumatoid arthritis (RA). Functional iron deficiency in ACD can be attributed to overexpression of the main iron regulatory hormone hepcidin leading to diversion of iron from the circulation into storage sites resulting in iron-restricted erythropoiesis. The aim is to investigate the role of circulating hepcidin and to uncover the frequency of IDA in RA. Read More

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https://www.pagepress.org/journals/index.php/hr/article/view
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http://dx.doi.org/10.4081/hr.2019.7708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434328PMC
February 2019
1 Read

Selective Inhibitors of T Cell Receptor Recognition of Antigen-MHC Complexes for Rheumatoid Arthritis.

ACS Med Chem Lett 2019 Apr 13;10(4):644-649. Epub 2019 Mar 13.

Institute of Chemistry of Molecular Recognition (ICRM) - CNR, Rome, Italy.

Autoreactive T cells specific to human collagen type II have a crucial role in the development of rheumatoid arthritis (RA) in the context of MHC class II allele HLA-DRB1-*04. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen bound to the allele MHC of class II may thus represent the target for the development of new drugs against RA. In this study, a structure-based pharmacophore model for potential small molecule inhibitors was developed from protein-protein interface structure. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466834PMC

The agreement between ultrasound-determined joint inflammation and clinical signs in patients with rheumatoid arthritis.

Arthritis Res Ther 2019 Apr 17;21(1):100. Epub 2019 Apr 17.

Department of Rheumatology and Clinical Immunology, Peking University First Hospital, No. 8 Xishiku Street, West District, Beijing, 100034, China.

Background: Ultrasound (US) is sensitive for detecting joint and tendon inflammation in patients with rheumatoid arthritis (RA). So far, which grade of abnormalities on US corresponds to clinical manifestations is unclear. This study aimed to investigate the agreement between US-detected joint inflammation and clinical signs (joint swelling and tenderness). Read More

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http://dx.doi.org/10.1186/s13075-019-1892-0DOI Listing

Targeting Interleukin-6 Signaling in Clinic.

Immunity 2019 Apr;50(4):1007-1023

Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita City, Osaka, Japan. Electronic address:

Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue injury, but excessive synthesis of IL-6 and dysregulation of IL-6 receptor signaling is involved in disease pathology. Therapeutic agents targeting the IL-6 axis are effective in rheumatoid arthritis, and applications are being extended to other settings of acute and chronic inflammation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193014
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http://dx.doi.org/10.1016/j.immuni.2019.03.026DOI Listing
April 2019
8 Reads

Combined Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis.

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE.

Objectives: Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint-lung inflammatory outcomes.

Methods: DBA/1J mice were intranasally treated with saline or ODE daily for 5 weeks. Read More

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http://dx.doi.org/10.1002/jbmr.3745DOI Listing
April 2019
1 Read

Multiplexed immunoassay approach to characterize antidrug antibody like specific reactivity.

Bioanalysis 2019 Apr 17. Epub 2019 Apr 17.

Pfizer, 1 Burtt Rd, Andover, MA 01810, USA.

Characterization of antidrug antibody (ADA) like reactivity has emerged as critical element of bioanalytical design and assessment of compound immunogenicity risk. Multiplex immunoassay was applied to detect and characterize ADA like reactivity using Photonic Ring Immunoassay platform (Genalyte). Specific binding to human IgE or human recombinant IL21-receptor-Fc fusion using exogenous reagents as surrogates for drug specific reactivity was investigated. Read More

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https://www.future-science.com/doi/10.4155/bio-2018-0072
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http://dx.doi.org/10.4155/bio-2018-0072DOI Listing
April 2019
2 Reads

Silicon intake and plasma level and their relationships with systemic redox and inflammatory markers in rheumatoid arthritis patients.

Adv Clin Exp Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Food Science and Dietetics, Wroclaw Medical University, Poland.

Background: The nutritional significance of silicon for the human body is highlighted by a continually growing body of evidence. In conditions of excessive reactive oxygen species and upregulated immune response, silicon has been observed to provide benefits, but its role in redox and inflammatory status has not yet been examined in rheumatoid arthritis (RA).

Objectives: The aim of this study was to assess the relationship of silicon intake and plasma level to systemic indices of redox status and inflammation in patients with RA. Read More

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http://dx.doi.org/10.17219/acem/105380DOI Listing
April 2019
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Care quality for rheumatoid arthritis patients in Quebec.

Int J Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Division of Clinical Epidemiology, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

Aim: The aims of this study were to: (a) measure the proportion of CARTaGENE rheumatoid arthritis (RA) patients fulfilling pre-specified quality indicators (ie disease-modifying antirheumatic drug [DMARD] use, regular follow up, use of folate supplementation, use of vitamin D and calcium, exercise and smoking status); and (b) examine variation in DMARD use with respect to patient age, sex, education and income.

Methods: A cohort of RA patients was constructed based on the CARTaGENE survey and health administrative database. CARTaGENE is a large, established, population-based study which recruited 19 995 participants from four metropolitan regions in Quebec. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13
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http://dx.doi.org/10.1111/1756-185X.13580DOI Listing
April 2019
3 Reads

Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases.

J Immunol Res 2019 12;2019:2160192. Epub 2019 Mar 12.

Department of Medicine, University of Wisconsin-Madison, 1685 Highland Avenue, Madison, WI 53705, USA.

In rheumatoid arthritis, an autoimmune inflammatory arthritis, citrullinated proteins are targeted by autoantibodies and thus thought to drive disease. Neutrophil extracellular traps (NETs) are a source of citrullinated proteins and are increased in rheumatoid arthritis and therefore also implicated in disease pathogenesis. However, not all NETs are citrullinated. Read More

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http://dx.doi.org/10.1155/2019/2160192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434303PMC
March 2019
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Obstetric outcomes in women with rheumatoid arthritis: Results from Nationwide Inpatient Sample Database 2003-2011.

Semin Arthritis Rheum 2019 Mar 23. Epub 2019 Mar 23.

University of Mississippi, 2500 North State Street, Jackson, MS 39232, United States.

Objective: Fertility is reduced in patients with Rheumatoid Arthritis due to unknown cause. Few studies have addressed pregnancy outcomes in RA. This study was undertaken to determine the frequency of complications occurring during pregnancy for women with RA and compare with the general obstetric population by using the largest inpatient care database. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.011DOI Listing
March 2019
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Correction to: Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase III trial in Japan.

Arthritis Res Ther 2019 Apr 16;21(1):99. Epub 2019 Apr 16.

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Toho University, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan.

Following publication of the original article [1], the authors reported an error in Table 2. Read More

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http://dx.doi.org/10.1186/s13075-019-1887-xDOI Listing
April 2019
2 Reads

How to Get the Most from Methotrexate (MTX) Treatment for Your Rheumatoid Arthritis Patient?-MTX in the Treat-to-Target Strategy.

J Clin Med 2019 Apr 15;8(4). Epub 2019 Apr 15.

Division of Rheumatology, Medical University Department, Kantonsspital Aarau, 5001 Aarau, Switzerland.

Methotrexate (MTX) is a remarkable drug with a key role in the management of rheumatoid arthritis (RA) at every stage of its evolution. Its attributes include good overall efficacy for signs and symptoms, inhibition of structural damage and preservation of function with acceptable and manageable safety, a large dose-titratable range, options for either an oral or parenteral route of administration, and currently unrivalled cost-effectiveness. It has a place as a monotherapy and also as an anchor drug that can be safely used in combination with other conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or used concomitantly with biological DMARDs or targeted synthetic DMARDs. Read More

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http://dx.doi.org/10.3390/jcm8040515DOI Listing
April 2019
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Mapping citrullinated sites in multiple organs of mice using hyper-citrullinated library.

J Proteome Res 2019 Apr 16. Epub 2019 Apr 16.

Protein citrullination (or deimination), irreversible post-translational modification, have been implicated in several physiological and pathological processes, including gene expression regulation, apoptosis, Rheumatoid arthritis, and Alzheimer's disease. Several researches have been carried out on citrullination in many conditions. However, until now, challenges in sample preparation and data analysis make it difficult to confidently identify a citrullinated protein and assign the citrullinated site. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00118DOI Listing
April 2019
3 Reads

Helios but not CD226, TIGIT and Foxp3 is a Potential Marker for CD4 Treg Cells in Patients with Rheumatoid Arthritis.

Cell Physiol Biochem 2019 ;52(5):1178-1192

Department of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH, United States,

Background/aims: Rheumatoid arthritis (RA) is a progressive, chronic, even disabling systemic autoimmune disease. Imbalance between pathogenic immune cells and immunosuppressive cells is associated with the pathogenesis and development of RA and other autoimmune diseases. As Foxp3 is also expressed on activated CD4 cells in the presence of inflammation, the identification of Treg cells in patients with RA remains a challenge. Read More

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http://dx.doi.org/10.33594/000000080DOI Listing
January 2019
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Automatic Hand Skeletal Shape Estimation from Radiographs.

IEEE Trans Nanobioscience 2019 Apr 12. Epub 2019 Apr 12.

Rheumatoid arthritis (RA) is an autoimmune disease whose common manifestation involves the slow destruction of joint tissue, damage that is visible in a radiograph. Over time, this damage causes pain and loss of functioning which depends, to some extent, on the spatial deformation induced by the joint damage. Building an accurate model of the current deformation and predicting potential future deformations is an important component of treatment planning. Read More

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http://dx.doi.org/10.1109/TNB.2019.2911026DOI Listing
April 2019
1 Read