155,593 results match your criteria Rheumatoid Arthritis

Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.

PLoS One 2021 21;16(6):e0252859. Epub 2021 Jun 21.

Faculty of Dentistry, Department of Restorative Dentistry, Unit of Periodontology, Universiti Kebangsaaan Malaysia, Kuala Lumpur, Malaysia.

Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Read More

View Article and Full-Text PDF

T cell transgressions: tales of T cell form and function in diversedisease states.

Int Rev Immunol 2021 Jun 21:1-42. Epub 2021 Jun 21.

Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, Colorado, USA.

Insights into T cell form, function, and dysfunction are rapidly evolving. T cells have remarkably varied effector functions including protecting the host from infection, activating cells of the innate immune system, releasing cytokines and chemokines, and heavily contributing to immunological memory. Under healthy conditions, T cells orchestrate a finely tuned attack on invading pathogens while minimizing damage to the host. Read More

View Article and Full-Text PDF

Geniposide downregulates the VEGF/SphK1/S1P pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro.

Phytother Res 2021 Jun 21. Epub 2021 Jun 21.

College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.

The VEGF/SphK1/S1P pathway is closely related to angiogenesis in rheumatoid arthritis (RA), but the precise underlying mechanisms are unclear at present. Here, we explored the involvement of the VEGF/SphK1/S1P cascade in RA models and determined the effects of GE intervention. Our results showed abnormal expression of proteins related to this pathway in RA synovial tissue. Read More

View Article and Full-Text PDF

GABAergic signaling by cells of the immune system: more the rule than the exception.

Cell Mol Life Sci 2021 Jun 21. Epub 2021 Jun 21.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

Gamma-aminobutyric acid (GABA) is best known as an essential neurotransmitter in the evolved central nervous system (CNS) of vertebrates. However, GABA antedates the development of the CNS as a bioactive molecule in metabolism and stress-coupled responses of prokaryotes, invertebrates and plants. Here, we focus on the emerging findings of GABA signaling in the mammalian immune system. Read More

View Article and Full-Text PDF

[How many patients with inflammatory rheumatic diseases have the technical prerequisites for video consultations and are also willing to use this to carry out visits by medical specialist visits?]

Z Rheumatol 2021 Jun 21. Epub 2021 Jun 21.

Rheumazentrum Ruhrgebiet am Marienhospital Herne, Ruhr-Universität Bochum, Claudiusstr. 45, 44649, Herne, Deutschland.

Background: The currently disseminating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and limited capacities in outpatient rheumatological care, pose questions about possible alternatives to clinical visits, also in view of the digital revolution. It is unclear whether and to what extent patients with inflammatory rheumatic diseases are willing and in a position to deal with the new media, such as video consultation.

Methods: In the middle of the pandemic in May 2020 outpatients were surveyed using a standardized questionnaire in order to document their possibilities and willingness to participate in a video consultation. Read More

View Article and Full-Text PDF

Association of autoimmune diseases with cardiomyopathy: a nationwide follow-up study from Sweden.

Eur Heart J Qual Care Clin Outcomes 2021 Jun 21. Epub 2021 Jun 21.

Center for Primary Health Care Research, Lund University, Sweden.

Background: Certain autoimmune diseases (AD), such as Crohn's disease and celiac diseases, have been linked to acute cardiovascular disorders. We examined whether there is an association between 43 different ADs and risk of subsequent hospitalization and mortality of cardiomyopathy in a nationwide follow-up study in Sweden.

Methods: All individuals in Sweden hospitalized with a main diagnosis of an AD (n = 955,410) without previous or coexisting cardiomyopathy, between January 1, 1987 and December 31 2018, were followed for hospitalization or mortality of cardiomyopathy. Read More

View Article and Full-Text PDF

Early radiological progression remains associated with long-term joint damage in real-world rheumatoid arthritis patients treated to the target of remission.

Scand J Rheumatol 2021 Jun 21:1-10. Epub 2021 Jun 21.

Department of Psychology, Health & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Enschede, The Netherlands.

: To evaluate radiological damage and to explore characteristics associated with radiological progression in rheumatoid arthritis (RA) treated to the target of remission in a real-world setting.: Baseline to 6 year follow-up data were used from an observational early RA cohort. Radiographs of hands and feet at baseline, 6 months, and 1, 3, and 6 years were scored using the modified Sharp/van der Heijde score (SHS). Read More

View Article and Full-Text PDF

Using a novel smartphone application for capturing of patient-reported outcome measures among patients with inflammatory arthritis:A randomized, crossover, agreement study.

Scand J Rheumatol 2021 Jun 21:1-9. Epub 2021 Jun 21.

Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark.

: In Denmark, patients with inflammatory arthritis (IA) have completed patient-reported outcome measures (PROMs) via touchscreens in the outpatient clinic since 2006. However, current technology makes it possible for patients to use their own smartphone via an application (app) developed for the Danish Rheumatology Database (DANBIO). This study aims to evaluate the agreement of PROMs between the DANBIO app and outpatient touchscreen in patients with IA. Read More

View Article and Full-Text PDF

Invalidation in fibromyalgia and rheumatoid arthritis and its effect on quality of life in Indian patients.

Int J Rheum Dis 2021 Jun 20. Epub 2021 Jun 20.

Department of Medicine, Government Medical College, Jammu, Jammu and Kashmir, India.

Aim: Fibromyalgia (FM) and rheumatoid arthritis (RA) patients face invalidation in the form of "discounting" and "lack of understanding". Invalidation can have effects on the quality of life (QoL) in these patients. We planned this study to look for invalidation in FM and RA Indian patients and see the correlation between invalidation and QoL. Read More

View Article and Full-Text PDF

Evaluation of bone erosion in rheumatoid arthritis patients by high-resolution peripheral quantitative computed tomography scans: Comparison between two semi-automated programs in a three-dimensional setting.

Int J Rheum Dis 2021 Jun 20. Epub 2021 Jun 20.

Bone Metabolism Laboratory, Rheumatology Division, Faculdade de Medicina FMUSP Universidade de Sao Paulo, Sao Paulo, Brazil.

Aim: The aim of this study was to compare OsiriX software with the previous published Medical Image Analysis Framework (MIAF) method to assess the volume of erosion in patients with rheumatoid arthritis (RA).

Methods: Forty RA patients underwent high-resolution peripheral quantitative computed tomography scans of the second and third metacarpophalangeal joints, and thirty-four patients with any bone erosion were enrolled. Two techniques were applied to erosion evaluation: (a) semi-automated MIAF software, and (b) semi-automated segmentation by free open-source Digital Imaging and Communications in Medicine viewer, OsiriX software. Read More

View Article and Full-Text PDF

Randomised, Double-Blind, Placebo-Controlled Study of Iguratimod in the Treatment of Active Spondyloarthritis.

Front Med (Lausanne) 2021 2;8:678864. Epub 2021 Jun 2.

Department of Rheumatology and Immunology, First Medical Center, General Hospital of Chinese People's Liberation Army, Beijing, China.

The effect of Iguratimod in the treatment of rheumatoid arthritis was confirmed in past studies. In terms of the mechanism of the effect and clinical application experience, Iguratimod has a potential value in the treatment of spondyloarthritis (SpA). This study evaluated the efficacy and safety of Iguratimod on active SpA. Read More

View Article and Full-Text PDF

An Update on Treatment Modalities for Ulnar Nerve Entrapment: A Literature Review.

Anesth Pain Med 2020 Dec 24;10(6):e112070. Epub 2020 Dec 24.

Southcoast Health Physicians Group Pain Medicine, Wareham, Massachusetts.

Context: Ulnar nerve entrapment is a relatively common entrapment syndrome second only in prevalence to carpal tunnel syndrome. The potential anatomic locations for entrapment include the brachial plexus, cubital tunnel, and Guyon's canal. Ulnar nerve entrapment is more so prevalent in pregnancy, diabetes, rheumatoid arthritis, and patients with occupations involving periods of prolonged elbow flexion and/or wrist dorsiflexion. Read More

View Article and Full-Text PDF
December 2020

Anti-inflammatory activity of different isolated sites of in complete Freund's adjuvant-induced arthritic rats.

Exp Ther Med 2021 Aug 8;22(2):848. Epub 2021 Jun 8.

Pharmacy Teaching and Research Department, College of Pharmacy, Wannan Medical College, Wuhu, Anhui 241002, P.R. China.

is a traditional Chinese medicine for treating arthritis and bruises. The aim of the present study was to investigate the anti-arthritic activities and possible associated mechanisms of different isolated sites of (DISC) in adjuvant-induced arthritis (AA) rats. The therapeutic effects of the extracts were assessed through changes in body weights, swelling rates, arthritis indexes (AI) and organ indexes. Read More

View Article and Full-Text PDF

Identification of the Main Active Components and Mechanism of Wang Bi Tablet in Treating Rheumatoid Arthritis Based on Integrative Pharmacology.

Front Pharmacol 2021 4;12:669551. Epub 2021 Jun 4.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Wang Bi tablet (WBT) is used to treat rheumatoid arthritis (RA) in China. We employed integrative pharmacology, including rapid analysis of chemical composition, pharmacological experiment, and network pharmacology analysis, to elucidate the active components and mechanism underlying the effect of WBT against RA. The chemical fingerprint of WBT was revealed by UPLC-QTOF-MS/MS, and the chemical composition was identified. Read More

View Article and Full-Text PDF

Rheumatoid Arthritis Accompanying Diffuse Panbronchiolitis.

Intern Med 2021 Jun 19. Epub 2021 Jun 19.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

A 58-year-old woman with rheumatoid arthritis (RA) visited our hospital complaining of a persistent cough and sputum for the past year. She had a high cold hemagglutinin titer and chronic sinusitis. Chest computed tomography revealed bilateral diffuse centrilobular nodules, bronchiectasis, and bronchial wall thickening. Read More

View Article and Full-Text PDF

Associations of loneliness and social isolation with physical and mental health among adolescents and young adults.

Perspect Public Health 2021 Jun 19:17579139211016077. Epub 2021 Jun 19.

Public Health & Health Services Research, DEFACTUM, Central Denmark Region, Aarhus N, Denmark.

Aims: The present study investigates whether loneliness and social isolation are associated with poor physical and mental health among adolescents and young adults, and whether age and gender play a role in the associations of loneliness and social isolation with mental and physical health.

Methods: This study used cross-sectional self-report data from the 2017 Danish Health and Morbidity Surveys titled 'How are you?' ( = 19,890,  = 22.6 years). Read More

View Article and Full-Text PDF

ROS-Responsive Berberine Polymeric Micelles Effectively Suppressed the Inflammation of Rheumatoid Arthritis by Targeting Mitochondria.

Nanomicro Lett 2020 Mar 20;12(1):76. Epub 2020 Mar 20.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China.

Rheumatoid arthritis (RA) is an autoimmune disease, which attacks human joint system and causes lifelong inflammatory condition. To date, no cure is available for RA and even the ratio of achieving remission is very low. Hence, to enhance the efficacy of RA treatment, it is essential to develop novel approaches specifically targeting pathological tissues. Read More

View Article and Full-Text PDF

A Molecular Signature Response Classifier to Predict Inadequate Response to Tumor Necrosis Factor-α Inhibitors: The NETWORK-004 Prospective Observational Study.

Rheumatol Ther 2021 Jun 19. Epub 2021 Jun 19.

Scipher Medicine, 221 Crescent Street, Suite 103A, Waltham, MA, 02453, USA.

Introduction: Timely matching of patients to beneficial targeted therapy is an unmet need in rheumatoid arthritis (RA). A molecular signature response classifier (MSRC) that predicts which patients with RA are unlikely to respond to tumor necrosis factor-α inhibitor (TNFi) therapy would have wide clinical utility.

Methods: The protein-protein interaction map specific to the rheumatoid arthritis pathophysiology and gene expression data in blood patient samples was used to discover a molecular signature of non-response to TNFi therapy. Read More

View Article and Full-Text PDF

Celastrol inhibits rheumatoid arthritis through the ROS-NF-κB-NLRP3 inflammasome axis.

Int Immunopharmacol 2021 Jun 17;98:107879. Epub 2021 Jun 17.

Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, School of Pharmacy, Binzhou Medical University, Yantai 264003, Shandong, China. Electronic address:

Emerging evidence indicates that NOD-like receptor protein 3 (NLRP3) inflammasome-induced inflammation plays a critical role in the pathogenesis of rheumatoid arthritis (RA). Celastrol (Cel) is a quinone-methylated triterpenoid extracted from Tripterygium wilfordii that is used to treat RA. However, researchers have not determined whether Cel exerts anti-RA effects by regulating the activation of the NLRP3 inflammasome. Read More

View Article and Full-Text PDF

De Quervain Tenosynovitis: An Evaluation of the Epidemiology and Utility of Multiple Injections Using a National Database.

J Hand Surg Am 2021 Jun 16. Epub 2021 Jun 16.

Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medicine, Chicago, IL. Electronic address:

Purpose: We hypothesized that repeat injections are associated with a decreased rate of success and that the success rate of injections correlates with patient comorbidities.

Methods: Using a commercially available insurance database, patients diagnosed with De Quervain tenosynovitis were identified using International Classification of Diseases, Ninth Revision and Tenth Revision codes and stratified by therapeutic interventions, including therapy, injections, and surgery, as well as comorbidities. Injection failure was defined as a patient receiving a repeat injection or subsequent surgical management. Read More

View Article and Full-Text PDF

Using adalimumab serum concentration to choose a subsequent biological DMARD in rheumatoid arthritis patients failing adalimumab treatment (ADDORA-switch): study protocol for a fully blinded randomised superiority test-treatment trial.

Trials 2021 Jun 19;22(1):406. Epub 2021 Jun 19.

Department of Rheumatology, Sint Maartenskliniek, PO box 9011, 6500 GM, Nijmegen, the Netherlands.

Background: A substantial proportion of rheumatoid arthritis (RA) patients discontinues treatment with tumour necrosis factor inhibitors (TNFi) due to inefficacy or intolerance. After the failure of treatment with a TNFi, treatment can be switched to another TNFi or a bDMARD with a different mode of action (non-TNFi). Measurement of serum drug concentrations and/or anti-drug antibodies (therapeutic drug monitoring (TDM)) may help to inform the choice for the next step. Read More

View Article and Full-Text PDF

Predictive analytics for step-up therapy: supervised or semi-supervised learning?

J Biomed Inform 2021 Jun 16:103842. Epub 2021 Jun 16.

Department of Biomedical Informatics, University of Utah, Salt Lake City, UT.

Background: Step-up therapy is a patient management approach that aims to balance the efficacy, costs and risks posed by different lines of medications. While the initiation of first line medications is a straightforward decision, stepping-up a patient to the next treatment line is often more challenging and difficult to predict. By identifying patients who are likely to move to the next line of therapy, prediction models could be used to help healthcare organizations with resource planning and chronic disease management. Read More

View Article and Full-Text PDF

Qualitative validation of audiovisual educational material for use on rheumatoid arthritis patients.

Rheumatol Int 2021 Jun 19. Epub 2021 Jun 19.

Laboratory of Cytokines and Autoimmunity, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos (UAEM), Av. Universidad 1001 col. Chamilpa, C.P. 62209, Cuernavaca, Morelos, México.

Medication compliance is critical to achieve therapeutic efficacy in patients with rheumatoid arthritis; however, among other factors, low patient-health literacy plays a negative role. Therefore, the development and validation of audiovisual educational material with the participation of health specialists and patients could lead to an improved level of compliance with treatment, while favoring its acceptance. To design and validate audiovisual educational material generated by a multidisciplinary and participative group of patients and health specialists. Read More

View Article and Full-Text PDF

Impact of the COVID-19 pandemic on treat to target strategies and physical consultations in > 7000 patients with inflammatory arthritis.

Rheumatology (Oxford) 2021 Jun 19. Epub 2021 Jun 19.

DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen, Denmark.

Objectives: To explore the impact of the COVID-19 pandemic on treat-to-target strategies (disease activity, remission rates) and access to physical consultations in patients with inflammatory rheumatic disease. Furthermore, to explore characteristics of patients with/without physical consultations in the clinic, and impact of early versus established disease.

Methods: Patients with rheumatoid arthritis(RA)/psoriatic arthritis(PsA)/axial spondyloarthritis(AxSpA) prospectively followed in the nationwide DANBIO-registry answered online questionnaires and reported patient reported outcomes (PROs) in June and November 2020. Read More

View Article and Full-Text PDF

Medicinal Plants and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Treatment of Arthritis: A Literature Review.

Altern Ther Health Med 2021 Jun 18. Epub 2021 Jun 18.

Context: Arthritis is an inflammatory disease of diarthrodial joints and is associated with swollen inflamed joints, disruption of joints, and loss of integrity of articular cartilage and synovial joints.

Objective: The current review intended to examine the data on the epidemiology, causes, clinical diagnosis, and prevention and control of different types of arthritis and on the use of medicinal plants in gouty arthritis.

Design: The research team performed a literature review, searching relevant literature databases, including bioRxiv, medRxiv, Google Scholar, Embase, PsychINFO, and PubMed. Read More

View Article and Full-Text PDF

Association between psoriasis and rheumatoid arthritis in a nationally representative US population.

J Am Acad Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Dermatology Research and Education Foundation, Irvine, CA, USA.

View Article and Full-Text PDF

Mechanistic insights into 5-lipoxygenase inhibition by pyocyanin: a molecular docking and molecular dynamics study.

J Biomol Struct Dyn 2021 Jun 18:1-9. Epub 2021 Jun 18.

Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Puttaparthi, Andhra Pradesh, India.

Pyocyanin, a redox-active phenazine pigment produced by , inhibits 5-lipoxygenase (5-LOX) activity. However, whether pyocyanin can directly block the enzymatic activity by binding at the active site still remains a question because of its ability to produce superoxide radicals and HO. With the objective of characterizing this mechanism, we carried out molecular docking and molecular dynamics simulations and performed Molecular Mechanics Poisson-Boltzmann surface area (MMPBSA) binding energy studies. Read More

View Article and Full-Text PDF

COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes.

JCI Insight 2021 Jun 18. Epub 2021 Jun 18.

Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

We explored the potential link between chronic inflammatory arthritis and COVID-19 pathogenic and resolving macrophage pathways and their role in COVID-19 pathogenesis. We found that BALF macrophage clusters FCN1pos and FCN1posSPP1pos predominant in severe COVID-19 were transcriptionally related to synovial tissue macrophage (STM) clusters CD48highS100A12pos and CD48posSPP1pos that drive Rheumatoid Arthritis (RA) synovitis. BALF macrophage cluster FABP4pos predominant in healthy lung was transcriptionally related to STM cluster TREM2pos that governs resolution of synovitis in RA remission. Read More

View Article and Full-Text PDF

Towards Personalising the Use of Biologics in Rheumatoid Arthritis: A Discrete Choice Experiment.

Patient 2021 Jun 18. Epub 2021 Jun 18.

Manchester Centre for Health Economics, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Introduction: There have been promising developments in technologies and associated algorithm-based prescribing ('stratified approach') to target biologics to sub-groups of people with rheumatoid arthritis (RA). The acceptability of using an algorithm-guided approach in practice is likely to depend on various factors.

Objective: This study quantified preferences for an algorithm-guided approach to prescribing biologics (termed 'biologic calculator'). Read More

View Article and Full-Text PDF

Ticagrelor added to methotrexate improves rheumatoid arthritis disease severity.

Rheumatology (Oxford) 2021 Jun 17. Epub 2021 Jun 17.

Center for the Prevention of Cardiovascular Disease, Department of Medicine, New York University School of Medicine, New York, NY, US.

View Article and Full-Text PDF