162,182 results match your criteria Rheumatoid Arthritis


Physical Activity Associates with Lower Systemic Inflammatory Gene Expression in Rheumatoid Arthritis.

J Rheumatol 2022 Jul 1. Epub 2022 Jul 1.

Division of Rheumatology, University of California, San Francisco, CA, USA; Department of Pediatrics, University of California, San Francisco, CA, USA; Division of Infectious Diseases, University of California, San Francisco, CA, USA; Department of Veterans Affairs Medical Center, San Francisco, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Conflict of interest statement: The authors declare that no conflict of interest exists. Acknowledgements: This work is supported by NIH/NIAMS R01 AR069616, NIH/NHLBI K23HL138461-01A1, and the Rheumatology Research Foundation. Corresponding Author: Sarah Patterson, M.D. Division of Rheumatology, University of California, San Francisco Box 0500, San Francisco, CA 94122 Email:

Objective: While general population studies have shown inverse associations between physical activity and common inflammatory biomarkers, the effects of physical activity on inflammatory gene expression and signaling pathways in rheumatoid arthritis (RA) remain unknown. We aimed to determine whether physical activity independently associates with expression of inflammatory genes among people with RA.

Methods: This was a prospective observational study of adults with RA. Read More

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Could Sampling Bias Be to Blame for Apparent Association Among Rheumatic Diseases?

J Rheumatol 2022 Jul 1. Epub 2022 Jul 1.

School of Medicine, Chung Shan Medical University; Department of Physical Medicine and Rehabilitation, Chung Shan Medical University Hospital; Institute of Medicine, Chung Shan Medical University; Graduate Institute of Integrated Medicine, China Medical University; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. P.Y. Liao and J.K. Yang contributed equally. The authors declare no conflicts of interest relevant to this work. Address correspondence to Dr. J.C.C. Wei, Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., Taichung City 40201, Taiwan. Email:

We have read with great interest the recent study by Meer et al on novel methods to identify risk factors for psoriatic arthritis (PsA), psoriasis, rheumatoid arthritis (RA), and ankylosing spondylitis. In that article, we appreciate that age, sex, BMI (calculated as weight in kilograms divided by height in meters squared), and time observed between the experimental group and control group were highly matched. However, we have a few suggestions to strengthen the conclusions in the study of Meer et al. Read More

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The course of fatigue during the development of Rheumatoid Arthritis and its relation with inflammation: a longitudinal study.

Joint Bone Spine 2022 Jun 28:105432. Epub 2022 Jun 28.

Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands; Department of Rheumatology, Erasmus Medical Center, Rotterdam, the Netherlands.

Objective Fatigue is a prominent and disabling symptom in patients with rheumatoid arthritis (RA), that is only partially explained by inflammation and responds poorly to DMARD-therapy. We hypothesized that inflammation explains fatigue to a larger extent in the phase of clinically suspect arthralgia (CSA), when persistent clinical arthritis is still absent and fatigue has not yet become chronic. We therefore studied the course of fatigue in CSA during progression to RA and the association with inflammation at CSA-onset and at RA-diagnosis. Read More

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Intra-articular Treatment of Digital Osteoarthritis by Radiosynoviorthesis-Clinical Outcome in Long-term Follow-up.

Clin Nucl Med 2022 Jul 1. Epub 2022 Jul 1.

Abteilung für Nuklearmedizin, Privatklinik Villach, Austria.

Purpose: This retrospective study analyzed the long-term effects of radiosynoviorthesis (RSO) with special emphasis to local joint pain in patients from 4 different RSO centers in Germany and Austria.

Methods: A total of 168 finger joints in 147 patients with digital joint OA were investigated. The indication for RSO was based on both clinical complaints and a proven synovitis, despite anti-inflammatory pharmacotherapy and previous intra-articular corticosteroid injections. Read More

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The Influencing Contexts and Potential Mechanisms Behind the Use of Web-Based Self-management Support Interventions: Realistic Evaluation.

JMIR Hum Factors 2022 Jul 1;9(3):e34925. Epub 2022 Jul 1.

Department of Primary and Community Care, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, Netherlands.

Background: Self-management can increase self-efficacy and quality of life and improve disease outcomes. Effective self-management may also help reduce the pressure on health care systems. However, patients need support in dealing with their disease and in developing skills to manage the consequences and changes associated with their condition. Read More

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Expression and clinical significance of the m6A reader in peripheral blood mononuclear cells from rheumatoid arthritis patients.

J Immunotoxicol 2022 Dec;19(1):53-60

Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang, China.

As an important m6A reader, the YT521-B homology domain family 2 (YTHDF2) has been shown to regulate mRNA degradation and translation, and to be involved in inflammation. However, little is known about the role of YTHDF2 in the autoimmune-based inflammatory disease rheumatoid arthritis (RA). To begin to ascertain any role for this reader, 74 RA patients and 63 healthy controls (HC) were recruited for this study. Read More

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December 2022

Naringenin as a natural immunomodulator against T cell-mediated autoimmune diseases: literature review and network-based pharmacology study.

Crit Rev Food Sci Nutr 2022 Jul 1:1-18. Epub 2022 Jul 1.

Infection and Immunity Institute and Translational Medical Center of Huaihe Hospital, Henan University, Kaifeng, China.

T cells, especially CD4 T helper (Th) cells, play a vital role in the pathogenesis of specific autoimmune diseases. Naringenin, a citrus flavonoid, exhibits anti-inflammatory, anti-oxidant, and antitumor properties, which have been verified in animal autoimmune disease models. However, naringenin's possible effects and molecular mechanisms in T cell-mediated autoimmune diseases are unclear. Read More

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Active tuberculosis infection in moroccan patients with rheumatic diseases under biologic therapy: A multicenter national study.

Int J Mycobacteriol 2022 Apr-Jun;11(2):175-182

Department of Rheumatology B, El Ayachi Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Background: The aim of this study was to evaluate the prevalence of active tuberculosis (TB) infection in Moroccan patients with rheumatic diseases under biologic therapy, and to describe the demographic characteristics of these patients as well as to explore potential risk factors.

Methods: This 14-year nationally representative multicenter study enrolled Moroccan patients with rheumatic diseases who had been treated with biologic therapy. Patient medical records were reviewed retrospectively for demographic characteristics, underlying rheumatic diseases, associated comorbidities, and TB-related data. Read More

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Immunomodulatory role of T helper cells in rheumatoid arthritis : a comprehensive research review.

Bone Joint Res 2022 Jul;11(7):426-438

Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, China.

Rheumatoid arthritis (RA) is an autoimmune disease that involves T and B cells and their reciprocal immune interactions with proinflammatory cytokines. T cells, an essential part of the immune system, play an important role in RA. T helper 1 (Th1) cells induce interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), and interleukin (IL)-2, which are proinflammatory cytokines, leading to cartilage destruction and bone erosion. Read More

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How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model.

Front Immunol 2022 10;13:930112. Epub 2022 Jun 10.

INSERM U1097 Immunogénétique de la Polyarthrite Rhumatoïde, Marseille, France.

The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE). RA is preceded by the emergence of disease specific anti citrullinated protein antibodies (ACPA). SE positive HLA-DRB1 alleles are associated with ACPA and ACPA positive RA, not with ACPA negative RA, suggesting that ACPA contribute to the pathogenesis of RA. Read More

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Identification of Immune-Related Hub Genes in Thymoma: Defects in CD247 and Characteristics of Paraneoplastic Syndrome.

Authors:
Lin-Fang Deng

Front Genet 2022 14;13:895587. Epub 2022 Jun 14.

College of Sciences, Shanghai University, Shanghai, China.

Thymomas (Ts) and thymic carcinomas (TCs) are rare primary tumors of the mediastinum. Paraneoplastic syndrome (PNS) is an important feature of thymoma, which presents great challenges to clinicians. The present study uses the weighted gene co-expression network analysis (WGCNA) to identify possible immunologic mechanisms of thymoma. Read More

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Serious Gaming and Artificial Intelligence in Rehabilitation of Rheumatoid Arthritis.

Stud Health Technol Inform 2022 Jun;295:562-565

Politehnica University Timioara, Department of Automation and Applied Informatics, 2, Vasile Pârvan Blvd., 300223, Timioara, România.

This paper presents a current situation of studies and applications which are using serious games and artificial intelligence (AI) in rehabilitation of rheumatoid arthritis, and possible future directions. The objectives of this paper are: to highlight the technologies used for recovery of patients with rheumatoid arthritis (RA), to summarize the state of the art of existing applications and to present the authors work, a software application that aims contributing to the recovery of the specific patients. At this stage the application was tested by a group of 10 patients from Medical Centre Sf. Read More

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Effect of Hydroxychloroquine on Influenza Prevention.

Stud Health Technol Inform 2022 Jun;295:343-344

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

The aim of this study was to assess whether long-term administration of hydroxychloroquine (HCQ) is protective from influenza in patients with rheumatoid arthritis and systemic lupus erythematosus. Using a propensity score-matched design, patients who were prescribed HCQ for more than 10 months were matched with patients of the same gender, age group, and Charlson Comorbidity Index score who did not receive HCQ. A logistic regression model was used to estimate the association between the HCQ exposure and influenza after adjusting for covariates. Read More

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Evaluation of tenosynovitis in patients with seronegative rheumatoid arthritis using microvascular flow imaging.

Med Eng Phys 2022 Jun 26:103839. Epub 2022 Jun 26.

Department of Ultrasound, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052 China.

Objectives: The purpose of this research was investigate the potential use of MVFI (microvascular flow imaging) in the assessment of tenosynovitis in cases with SNRA (seronegative rheumatoid arthritis).

Methods: Fifty-six SNRA cases and 20 HCs (healthy controls) were enrolled, and all of them were subjected to ultrasonographic examination of the compartments I-VI of the extensor tendons of the wrist, flexor carpi radialis and flexor tendons of the five digits. Each tendon synovial sheath was semi-quantitatively scored by GS (gray-scale) ultrasound, PD (power Doppler) ultrasound, and MVFI. Read More

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Hydroxychloroquine: Heart-Throb No More?

J Am Coll Cardiol 2022 Jul;80(1):47-49

Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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Cardiovascular Risks of Hydroxychloroquine vs Methotrexate in Patients With Rheumatoid Arthritis.

J Am Coll Cardiol 2022 Jul;80(1):36-46

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Background: Hydroxychloroquine is often used as a first-line treatment of rheumatoid arthritis despite limited evidence on its cardiovascular risk.

Objectives: We conducted a cardiovascular safety evaluation comparing hydroxychloroquine to methotrexate among patients with rheumatoid arthritis.

Methods: Using Medicare data (2008-2016), we identified 54,462 propensity score-matched patients with rheumatoid arthritis, aged ≥65 years, who initiated hydroxychloroquine or methotrexate. Read More

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Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial.

Lancet Respir Med 2022 Jun 27. Epub 2022 Jun 27.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK; Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK.

Background: Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the S1 receptor-binding domain (S1-RBD) of the SARS-CoV-2 spike protein compared with uninterrupted treatment in patients with immune-mediated inflammatory diseases.

Methods: We did an open-label, prospective, two-arm, parallel-group, multicentre, randomised, controlled, superiority trial in 26 hospitals in the UK. Read More

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A MUC5B Gene Polymorphism, rs35705950-T Confers Protective Effects Against COVID-19 Hospitalization but not Severe Disease or Mortality.

Am J Respir Crit Care Med 2022 Jun 30. Epub 2022 Jun 30.

Vanderbilt University Medical Center, 12328, Division of Cardiovascular Medicine, Department of Medicine, Nashville, Tennessee, United States.

Rationale: A common MUC5B gene polymorphism, rs35705950-T, is associated with idiopathic pulmonary fibrosis (IPF), but its role in SARS-CoV-2 infection and disease severity is unclear.

Objectives: To assess whether rs35705950-T confers differential risk for clinical outcomes associated with COVID-19 infection among participants in the Million Veteran Program (MVP).

Methods: The MUC5B rs35705950-T allele was directly genotyped among MVP participants; clinical events and comorbidities were extracted from the electronic health records. Read More

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Predictors of Treatment Change Among Patients with Rheumatoid Arthritis Treated with TNF Inhibitors as First-Line Biologic Agent in the USA: A Cohort Study from Longitudinal Electronic Health Records.

BioDrugs 2022 Jun 30. Epub 2022 Jun 30.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA.

Background: Previous observational studies utilizing administrative claims data have largely been unable to consider clinical factors that may be related to patterns of drug use among patients with rheumatoid arthritis (RA).

Objective: To understand predictors of treatment changes following initiation of a tumor necrosis factor inhibitor (TNFi) using nation-wide electronic health record (EHR) data in the USA.

Methods: The Optum Immunology Condition EHR data (01/01/2011-09/30/2019) was used to identify a population of adult patients with RA initiating a TNFi as the first line biologic disease-modifying anti-rheumatic drug (DMARD). Read More

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Minimally invasive lateral occipitocervical fixation: case series and technique description.

Eur Spine J 2022 Jun 30. Epub 2022 Jun 30.

Department of Neurosurgery, Copernicus Hospital Gdansk, ul. Nowe Ogrody 1-6, 80-803, Gdansk, Poland.

Purpose: Occipitocervical junction (OCJ) instability is commonly treated with fixation via open posterior approach. The use of intraoperative navigation allows us to perform occipitocervical fixation via minimally invasive approach. We report a series of patients treated with percutaneous occipitocervical fixation, describing the surgical procedure in detail and discussing the technique. Read More

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The Effect of Anti-rheumatic Drugs on the Skeleton.

Calcif Tissue Int 2022 Jun 30. Epub 2022 Jun 30.

Amsterdam Rheumatology and Immunology Centre, Amsterdam, The Netherlands.

The therapeutic armamentarium for rheumatoid arthritis has increased substantially over the last 20 years. Historically antirheumatic treatment was started late in the disease course and frequently included prolonged high-dose glucocorticoid treatment which was associated with accelerated generalised bone loss and increased vertebral and non-vertebral fracture risk. Newer biologic and targeted synthetic treatments and a combination of conventional synthetic DMARDs prevent accelerated systemic bone loss and may even allow repair of cortical bone erosions. Read More

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Toxic effects of pesticides on cellular and humoral immunity: an overview.

Immunopharmacol Immunotoxicol 2022 Jun 30:1-30. Epub 2022 Jun 30.

Laboratório de Toxicologia, Departamento de Análises, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brasil.

People are exposed to pesticides through food, drinking water, and the environment. These compounds are associated with several disorders, such as inflammatory diseases, rheumatoid arthritis, cancer, and a condition related to metabolic syndrome. The immunotoxicants or immunotoxic compounds can cause a wide variety of effects on immune function, altering humoral immunity and cell-mediated immunity, resulting in adverse effects to the body. Read More

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K23-AR-073931 Identifying Factors Associated With Treatment Response in Rheumatoid Arthritis Clinical Trials.

ACR Open Rheumatol 2022 Jun 30. Epub 2022 Jun 30.

Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA.

Objective: Despite a wealth of studies evaluating rheumatoid arthritis (RA) therapies, it remains difficult to compare efficacies across trials due to heterogeneous study populations. We sought to identify patient/trial characteristics associated with clinical response to enable fairer comparisons.

Methods: We reviewed 565 disease-modifying antirheumatic drug studies compiled for American College of Rheumatology (ACR) management guidelines. Read More

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Citrus Flavonoids and Autoimmune Diseases: A Systematic Review of Clinical Studies.

Curr Med Chem 2022 Jun 29. Epub 2022 Jun 29.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.

Background: Autoimmune diseases are chronic disorders in which the immune system does not recognize and attacks one self's healthy components. In this context, although natural remedies might represent a promising therapeutic strategy, evidence regarding Citrus flavonoids is still controversial.

Objective: To summarize and critically discuss the clinical evidence on the effects of Citrus flavonoids for the management of autoimmune diseases. Read More

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Educational case: Osteoarthritis.

Acad Pathol 2022 21;9(1):100035. Epub 2022 Jun 21.

Department of Pathology & Anatomy, Eastern Virginia Medical School, Norfolk, VA, USA.

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Risk of Autoimmune Diseases Following Optic Neuritis: A Nationwide Population-Based Cohort Study.

Front Med (Lausanne) 2022 13;9:903608. Epub 2022 Jun 13.

Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Objectives: Optic neuritis is (ON) is believed to be an immune-mediated disease; however, the association between optic neuritis and autoimmune diseases remains unclear. This study aimed to identify the incidence rate and adjusted hazard ratio (aHR) of autoimmune diseases in patients with optic neuritis.

Methods: This nationwide, population-based, retrospective cohort study collected patients' data between 1999 and 2013 from the National Health Insurance Research Database in Taiwan. Read More

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Biologically Synthesized Peptides Show Remarkable Inhibition Activity against Angiotensin-Converting Enzyme: A Promising Approach for Peptide Development against Autoimmune Diseases.

Biomed Res Int 2022 20;2022:2396192. Epub 2022 Jun 20.

Department of Zoology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Angiotensin-converting enzyme (ACE) regulates several biological functions besides its vital role in immune functions. ACE is elevated in immune cells in inflammatory diseases including atherosclerosis, granuloma, chronic kidney disease, and also autoimmune diseases, like multiple sclerosis, rheumatoid arthritis, and type I diabetes. No significant information prevails in the literature regarding the isolation, identification, and profiling of potential ACE inhibitory peptides. Read More

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52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men.

ERJ Open Res 2022 Apr 27;8(2). Epub 2022 Jun 27.

Research Unit of Internal Medicine, Dept of Internal Medicine, Division of Infectious Diseases, University of Oulu and Oulu University Hospital, Oulu, Finland.

Background: Knowledge of pneumonia incidence and risk factors in adults is mainly based on clinical studies of selected patient data and registers with ageing populations. Prospective population-based investigations, such as birth cohort studies, are needed to understand pneumonia incidence and risk factors among young and working-age populations.

Methods: Northern Finland Birth Cohort (NFBC) 1966 data (n=6750) were analysed for pneumonia incidence and risk factors. Read More

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Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database.

BMC Rheumatol 2022 Jun 30;6(1):44. Epub 2022 Jun 30.

Division of Rheumatology, University Hospitals/Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106, USA.

Background: Increased cancer-risk has been reported with rheumatoid arthritis and systemic lupus erythematosus, but the risk is poorly studied in ankylosing spondylitis (AS). Conflicting data in AS have been reported in Asia and Europe, with lack of US population-based studies. Our objective is to study the prevalence of cancer in patients with AS in the US. Read More

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Impact of Bariatric Surgery on Outcomes of Patients with Rheumatoid Arthritis: a Propensity Score-Matched Analysis of US Nationwide Inpatient Sample, 2005-2018.

Obes Surg 2022 Jun 29. Epub 2022 Jun 29.

Division of General Surgery, Department of Surgery, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi City, 600, Taiwan.

Purpose: Obesity has been considered one of the risk factors with more critical disease progression and poor treatment response in rheumatoid arthritis (RA). We herein utilized an extensive, nationally representative database to examine the impact of bariatric surgery on clinical outcomes in RA patients.

Materials And Methods: This retrospective analysis utilized nationally representative data of the Healthcare Cost and Utilization Project-National Inpatient Sample database (HCUP-NIS) from 2005 to 2018. Read More

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