149,504 results match your criteria Rheumatoid Arthritis


Antibacterial and antibiofilm effects of flufenamic acid against methicillin-resistant Staphylococcus aureus.

Pharmacol Res 2020 Jul 7:105067. Epub 2020 Jul 7.

Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Methicillin-resistant Staphylococcus aureus (MRSA) infections are one of the most serious surgery complications, and their prevention is of utmost importance. Flufenamic acid is a non-steroid anti-inflammatory drug approved for clinical use to relieve inflammation and pain in rheumatoid arthritis patients. In this study, we explored the antibacterial efficacy of flufenamic acid and the mechanisms underlying this effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2020.105067DOI Listing

Medicopsis Romeroi infection presenting as disseminated nodules and sinuses in a patient with chronic rheumatoid arthritis.

J Eur Acad Dermatol Venereol 2020 Jul 10. Epub 2020 Jul 10.

Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Medicopsis romeroi, formerly known as Pyrenochaeta romeroi, usually presents as solitary localised subcutaneous cyst in immunocompromised patients. We report an unusual manifestation of the fungal infection in a patient of rheumatoid arthritis. A farmer in 60s presented with multiple painless nodules over legs for the last one year. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16811DOI Listing

Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society.

J Hypertens 2020 Jul 6. Epub 2020 Jul 6.

Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité.

: Inflammation is a physiological response to aggression of pathogenic agents aimed at eliminating the aggressor agent and promoting healing. Excessive inflammation, however, may contribute to tissue damage and an alteration of arterial structure and function. Increased arterial stiffness is a well recognized cardiovascular risk factor independent of blood pressure levels and an intermediate endpoint for cardiovascular events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/HJH.0000000000002508DOI Listing

Scientific Productivity in Rheumatoid Arthritis: A Global Survey of Research Activity.

J Clin Rheumatol 2020 Jul 6. Epub 2020 Jul 6.

From the Department of Spine Surgery, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, China.

Objectives: Assessment of scientific productivity provides a macroscopic view of research activity in a specific field. However, no analyses of rheumatoid arthritis (RA) have been published to date. Thus, this study aimed to investigate the characteristics of studies published on RA worldwide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000001475DOI Listing

Ultra-fast detection and quantification of nucleic acids by amplification-free fluorescence assay.

Analyst 2020 Jul 10. Epub 2020 Jul 10.

Department of Chemistry, Technical University of Denmark, 207 Kemitorvet, 2800 Kgs. Lyngby, Denmark.

Two types of clinically important nucleic acid biomarkers, microRNA (miRNA) and circulating tumor DNA (ctDNA) were detected and quantified from human serum using an amplification-free fluorescence hybridization assay. Specifically, miRNAs hsa-miR-223-3p and hsa-miR-486-5p with relevance for rheumatoid arthritis and cancer related mutations BRAF and KRAS of ctDNA were directly measured. The required oligonucleotide probes for the assay were rationally designed and synthesized through a novel "clickable" approach which is time and cost-effective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0an00676aDOI Listing

Engineered IgG-targets identify clinically and pathophysiologically relevant rheumatoid factor epitopes.

Arthritis Rheumatol 2020 Jul 10. Epub 2020 Jul 10.

Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, Netherlands.

Objectives: Rheumatoid factors (RFs), anti-IgG autoantibodies strongly associated with rheumatoid arthritis (RA), are also found in other diseases and in healthy individuals. RFs bind to various epitopes in the constant (Fc-) domain of IgG; therefore, disease-specific reactivity patterns may exist. A new approach was developed to dissect RF epitope binding patterns across different diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.41430DOI Listing

Does Older Age have an Impact on Rituximab Efficacy and Safety? Results from the NOR-DMARD Register.

Drugs Aging 2020 Jul 9. Epub 2020 Jul 9.

Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.

Objective: The objective of this study was to compare the efficacy and safety of rituximab in older vs younger patients with rheumatoid arthritis.

Methods: Data on 367 patients with rheumatoid arthritis treated with rituximab in the Norwegian Disease-Modifying Antirheumatic Drug (NOR-DMARD) register were analysed, comparing patients aged ≥ 65 years (n = 91) with patients aged < 65 years (n = 276). Drug survival was compared using a Kaplan-Meier analysis and Cox proportional hazard models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40266-020-00782-xDOI Listing

Healthcare-Related Costs Associated with Switching Subcutaneous Tumor Necrosis Factor-α Inhibitor in the Treatment of Inflammatory Arthritis: a Retrospective Study.

Adv Ther 2020 Jul 9. Epub 2020 Jul 9.

Center for Observational and Real-World Evidence, Merck & Co., Inc, Kenilworth, NJ, USA.

Introduction: Subsequent lines of subcutaneous tumor necrosis factor alpha inhibitor (SC-TNFi) treatment may be well motivated in the management of rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)-collectively named inflammatory arthritis (IA). However, the costs associated with switching SC-TNFis are largely unknown. The objective of this retrospective observational study was to explore costs of healthcare resource utilization (HCRU) associated with switching SC-TNFi treatment among biologic-naïve Swedish patients with IA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12325-020-01425-8DOI Listing

A Study on Association Between Protein Carbonyl and Anti-cyclic Citrullinated Peptide Antibody in Rheumatoid Arthritis: Introducing a New Supplementary Biomarker.

Indian J Clin Biochem 2020 Jul 5;35(3):347-352. Epub 2019 Mar 5.

Surgical Oncology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.

Redox state and immune mechanisms are two major factors implicated in rheumatoid arthritis (RA). Regarding some limitations of anti-cyclic citrullinated peptide (anti-CCP) antibody in RA diagnosis, recruiting another strong marker of oxidative stress could lead to more definitive diagnosis. To evaluate the potential of protein carbonyl content as a supplementary biomarker for RA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12291-019-00823-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326851PMC

Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the mutation.

Ann Rheum Dis 2020 Jul 9. Epub 2020 Jul 9.

Department of Pediatrics, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Objectives: To collect clinical information and mutation data on patients with Blau syndrome and to evaluate their prognosis.

Methods: Fifty patients with mutations were analysed. The activity of each mutant was evaluated in HEK293 cells by reporter assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2020-217320DOI Listing

Parenting problems postpartum can be detected early in pregnancy in patients with rheumatoid arthritis.

RMD Open 2020 Jul;6(2)

Rheumatology, Erasmus MC, Rotterdam, Netherlands.

Objective: To describe parenting disability postpartum in patients with rheumatoid arthritis (RA) using the Parenting Disability Index and to determine early in pregnancy which patients will face parenting problems postpartum.

Methods: Data were collected from a prospective study on pregnancy and RA (Pregnancy induced Amelioration of Rheumatoid Arthritis study). Postpartum visits were performed at 6, 12 and 26 weeks after delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/rmdopen-2020-001276DOI Listing

Trends of lymphoma incidence in US veterans with rheumatoid arthritis, 2002-2017.

RMD Open 2020 Jul;6(2)

Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Objective: Past epidemiological studies have consistently demonstrated a link between rheumatoid arthritis (RA) and the incidence of lymphoma and it has been posited that high systemic inflammatory activity is a major risk determinant of lymphomagenesis. Given advances in the therapeutic armamentarium for RA management in recent years, the resulting lower level of disease activity could have led to a decline in lymphoma incidence in patients with RA. This study examined recent trends in lymphoma incidence in US veterans with RA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/rmdopen-2020-001241DOI Listing

Methotrexate and rheumatoid arthritis associated interstitial lung disease.

Eur Respir J 2020 Jul 9. Epub 2020 Jul 9.

Department of Rheumatology, DMU Locomotion, INSERM UMR1152, Hôpital Bichat-Claude Bernard, APHP, Université de Paris, Paris, France

Question Addressed By The Study: Methotrexate (MTX) is a key anchor drug for rheumatoid arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of RA. Whether MTX exposure increases the risk of ILD in patients with RA is disputed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1183/13993003.00337-2020DOI Listing

The impact of lifestyle behaviours, physical activity and smoking on morbidity and mortality in patients with rheumatoid arthritis.

Best Pract Res Clin Rheumatol 2020 Jul 6:101562. Epub 2020 Jul 6.

Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Rheumatoid arthritis (RA) is associated with pain, disability and increased risk of developing comorbidities and premature mortality. While these poor outcomes have improved in line with advances in the treatment of RA, they still persist to some degree today. Physical activity and smoking are two areas of patients' lives where changes may have a substantial impact on the poor outcomes associated with RA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.berh.2020.101562DOI Listing

T-Cell Large Granular Lymphocyte Leukemia in a Patient With Rheumatoid Arthritis.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620941303

Nassau University Medical Center, East Meadow, NY, USA.

Large granular lymphocyte leukemia (LGL) is a clonal, lymphoproliferative disorder with an indolent disease course. T-cell LGL (T-LGL) is the most common type of LGL driven from T-cell lineage (85%). The coexistence of T-LGL with several types of autoimmune disorders, mostly rheumatoid arthritis (RA), has been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2324709620941303DOI Listing

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19.

Int Immunopharmacol 2020 Jul 1;86:106749. Epub 2020 Jul 1.

Department of Pharmacy, Wuxi People's Hospital Attached to Nanjing Medical University, Wuxi 214023, Jiangsu, China. Electronic address:

In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly spread all over the world. Recently, a cell surface protein, known as angiotensin-converting enzyme II (ACE2), has been identified to be involved in receptor-mediated endocytosis for SARS-CoV-2 entry to the cells. Many studies have reported the clinical characteristics of COVID-19: sudden deterioration of disease around 1-2 weeks after onset; much lower level of lymphocytes, especially natural killer (NK) cells in peripheral blood; extremely high pro-inflammatory cytokines and C reactive protein (CRP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2020.106749DOI Listing

Efficacy of baricitinib in treating rheumatoid arthritis: Modulatory effects on fibrotic and inflammatory biomarkers in a real-life setting.

Int Immunopharmacol 2020 Jul 6;86:106748. Epub 2020 Jul 6.

Respiratory Diseases and Lung Transplantation, Department of Medical and Surgical Sciences & Neurosciences, University of Siena, Siena, Italy.

Background: Baricitinib is a JAK inhibitor that blocks intracellular signalling pathways of inflammatory cytokines recommended for Rheumatoid arthritis (RA) patients not responding to initial treatment. Among RA extrareticular features, interstitial lung involvement is primarly characterized by fibrotic evolution. The aim of the present study was to analyse the effects of baricitinib in a population of RA and RA-ILD patients in a real-life setting, describing any changes in lung function parameters, serum inflammatory biomarkers and fibrotic biomarkers after 6 months of treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2020.106748DOI Listing

Rheological properties of synovial fluid due to viscosupplements: A review for osteoarthritis remedy.

Comput Methods Programs Biomed 2020 Jul 3;196:105644. Epub 2020 Jul 3.

Department of Mechanical Engineering, University of West Attica, 12210 Athens, Greece. Electronic address:

The synovial fluid is a transparent electrolyte solution included in joints to provide lubrication helping the proper movement. It exhibits complex rheological properties due to the interaction among its constituents i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmpb.2020.105644DOI Listing

Natural products action on pathogenic cues in autoimmunity: Efficacy in systemic lupus erythematosus and rheumatoid arthritis as compared to classical treatments.

Pharmacol Res 2020 Jul 6:105054. Epub 2020 Jul 6.

The Second Affiliated Hospital and School of Pharmacy, Dalian Medical University, Dalian, Liaoning, China. Electronic address:

Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), which are characterized by self-perpetuating inflammation and tissue/organ damage, resulting from the failure of lymphocyte auto-tolerance, cause morbidity and mortality worldwide. The current drugs or therapies including conventional non-steroidal anti-inflammatory drugs (NSAIDs) and disease-modifying anti-rheumatic drugs (DMARDs), as well as several biologic therapies such as B cell-targeted, T cell-targeted, cytokines-targeted and cytokines receptors-targeted therapy, cannot completely cure SLE and RA, and are always accompanied by unexpected side effects. Therefore, more studies have explored new methods for therapy and found that the herbal medicine as well as its natural products (NPs) exhibited promising therapeutic value through exerting effects of immunomodulation, anti-inflammation, anti-oxidation, and anti-apoptosis, etc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2020.105054DOI Listing

Basic Immunology may lead to translational therapeutic rationale:: SARS-CoV-2 and Rheumatic Diseases.

Eur J Clin Invest 2020 Jul 9:e13342. Epub 2020 Jul 9.

Division of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy.

COVID-19 pandemia is a major concern for patients and health care systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analyzing the basic biology of single diseases, the data suggest that there is an "immunological umbrella" that seems to protect against the infection, through IFN type 1 and NK cell function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/eci.13342DOI Listing

Multiple extremity necrosis in fatal calciphylaxis: Case report.

J Bras Nefrol 2020 Jul 8. Epub 2020 Jul 8.

Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Departamento de Medicina, São Paulo, SP, Brazil.

Introduction: The clinical impact of vascular calcification is well established in the context of cardiovascular morbidity and mortality, but other clinical syndromes, such as calciphylaxis, although less frequent, have a significant impact on chronic kidney disease.

Methods: Case report of a 27-year-old woman, who had complained of bilateral pain in her toes for 3 days, with the presence of small necrotic areas in the referred sites. She had a history of type 1 diabetes (25 years ago), with chronic kidney disease, on peritoneal dialysis, in addition to rheumatoid arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2175-8239-JBN-2020-0025DOI Listing

Biological therapy safety in chronic inflammatory arthropathy patients.

Eur J Rheumatol 2020 Apr 2;7(2):53-59. Epub 2020 Jan 2.

Galicia Sur Biomedical Foundation, University Hospital Complex of Vigo Estrada Clara Campoamor, Pontevedra, Spain.

Objective: The marketing of biological therapies transformed the treatment of rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. But there is still concern about patient safety and management in daily clinical practice. The aim of this study was to estimate risk factors of the adverse effects in a cohort of Spanish patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/eurjrheum.2019.19123DOI Listing

Chronic treatment with hydroxychloroquine and SARS-CoV-2 infection.

J Med Virol 2020 Jul 9. Epub 2020 Jul 9.

Unidade de Investigação Cardiovascular (UniC), Faculdade de Medicina da Universidade do Porto and Hospital CUF, Porto, Portugal.

Background: Hydroxychloroquine sulphate (HCQ) is being scrutinized for repositioning in the treatment and prevention of SARS-Cov-2 infection. This antimalarial drug is also chronically used to treat patients with autoimmune diseases.

Methods: By analysing the Portuguese anonymized data on private and public based medical prescriptions we have identified all cases chronically receiving HCQ for the management of diseases such as systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmv.26286DOI Listing

Efficacy and safety of peficitinib in rheumatoid arthritis.

Authors:
Yuko Kaneko

Mod Rheumatol 2020 Jul 9:1-15. Epub 2020 Jul 9.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Peficitinib is a Janus kinase (JAK) inhibitor, newly developed and approved in Japan. In contrast to other JAK inhibitors, it is a unique pan-JAK inhibitor, demonstrating inhibition of all JAKs. In patients with rheumatoid arthritis with an inadequate response to previous disease-modifying anti-rheumatic drugs, the efficacy of peficitinib (100 mg and 150 mg) has been confirmed with a comparison to placebo in Phase 2b and 3 trials conducted in Asia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14397595.2020.1794103DOI Listing

Relationship between the physician-based clinical scale for foot and ankle surgery and patient-reported outcomes in patients with long-standing rheumatoid arthritis: Results from a multicenter prospective observational cohort study.

Mod Rheumatol 2020 Jul 9:1-20. Epub 2020 Jul 9.

Department of Rheumatology, Niigata Rheumatic Center, Niigata, Japan.

Objectives: To validate and establish targets for the physician-based clinical scale for foot surgery in rheumatoid arthritis (RA) patients based on patient-reported outcomes from a multicenter prospective cohort.

Methods: We collected data on demographics, values from the RA foot and ankle scale by the Japanese Society for Surgery of the Foot (JSSF-RA), and patient-reported outcomes (PROs) including the Health Assessment Questionnaire Disability Index (HAQ-DI) before (baseline) and 6 and 12 months after joint surgery. Target values for JSSF-RA were determined according to the lower limit of the 95% CI of JSSF-RA in patients with HAQ-DI ≤0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14397595.2020.1794101DOI Listing

Comorbid disease drives short-term hospitalization outcomes in patients with multiple sclerosis.

Neurol Clin Pract 2020 Jun;10(3):255-264

Department of Neurology (AM, DPT, JAC, AP, AWW), University of Pennsylvania Perelman School of Medicine; Department of Neurology Translational Center of Excellence for Neuroepidemiology (DPT, JAC, AWW), Neurological Outcomes and Disparities Research, University of Pennsylvania Perelman School of Medicine; Department of Biostatistics (AWW), Epidemiology and Informatics, University of Pennsylvania; Center for Clinical Epidemiology and Biostatistics (AWW), University of Pennsylvania Perelman School of Medicine; and Leonard Davis Institute of Health Economics (AWW), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objective: Readmission is used as a quality indicator and is the primary target outcome for disease-modifying therapy (DMT) for multiple sclerosis (MS). However, data on readmissions for patients with MS are limited.

Methods: Using the US Nationwide Readmissions Database, we performed a retrospective cohort study of adults hospitalized for MS in 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/CPJ.0000000000000838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292556PMC

The challenges in classifying rheumatoid arthritis-associated interstitial lung disease.

J Thorac Dis 2020 Jun;12(6):3000-3003

Research Unit of Internal Medicine, University of Oulu & Medical Research Center (MRC) Oulu, Oulu University Hospital, Oulu, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/jtd.2020.03.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330799PMC

Drug-induced Bullous Pemphigoid and Lupus Erythematosus Occurring under Anti-TNF-α and IL-6 Therapy in a Patient with Rheumatoid Arthritis.

Intern Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, Japan.

A 65-year-old Japanese woman, who was diagnosed with rheumatoid arthritis and Sjögren's syndrome with various autoantibodies including anti-DNA antibody, developed bullous pemphigoid and hematological abnormalities like lupus erythematosus after adalimumab therapy. The discontinuation of adalimumab resolved those disorders but polyarthritis thereafter relapsed. The introduction of abatacept was not effective, but tocilizumab was found to be effective for polyarthritis, however, thereafter both bullous disease and severe pancytopenia developed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.4646-20DOI Listing

Strategies for the assessment of competences during rheumatology training across Europe: results of a qualitative study.

RMD Open 2020 Jul;6(2)

EULAR, Zurich, Switzerland.

Objectives: To gain insight into current methods and practices for the assessment of competences during rheumatology training, and to explore the underlying priorities and rationales for competence assessment.

Methods: We used a qualitative approach through online focus groups (FGs) of rheumatology trainers and trainees, separately. The study included five countries-Denmark, the Netherlands, Slovenia, Spain and the United Kingdom. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/rmdopen-2020-001183DOI Listing

Increased primary care use for musculoskeletal symptoms, infections and comorbidities in the years before the diagnosis of inflammatory arthritis.

RMD Open 2020 Jul;6(2)

Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Amsterdam, Netherlands.

Objectives: Little is known about relevant events in the at-risk phase of rheumatoid arthritis before the development of clinically apparent inflammatory arthritis (IA). The present study assessed musculoskeletal symptoms, infections and comorbidity in future IA patients.

Methods: In a nested case-control study using electronic health records of general practitioners, the frequency and timing of 192 symptoms or diseases were evaluated before a diagnosis of IA, using the International Classification of Primary Care coding system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/rmdopen-2019-001163DOI Listing

Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases.

Cells 2020 Jul 6;9(7). Epub 2020 Jul 6.

Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79098 Freiburg, Germany.

Deregulated NF-k activation is not only involved in cancer but also contributes to the pathogenesis of chronic inflammatory diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). Ideally, therapeutic NF-KappaB inhibition should only take place in those cell types that are involved in disease pathogenesis to maintain physiological cell functions in all other cells. In contrast, unselective NF-kappaB inhibition in all cells results in multiple adverse effects, a major hindrance in drug development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells9071627DOI Listing

Autoimmune Conditions: Rheumatoid Arthritis.

Authors:
Robert C Langan

FP Essent 2020 07;494:11-17

St. Luke's Family Medicine Residency, 2830 Easton Ave, Bethlehem, PA 18017.

Rheumatoid arthritis (RA) is the most common autoimmune inflammatory arthritis, and is seen more commonly in women, smokers, and individuals with a family history of RA. It should be considered if unexplained pain and swelling in the metacarpophalangeal and/or metatarsophalangeal joints and morning stiffness of fingers lasting for longer than 30 minutes are present. RA may be present in the lungs, skin, and eyes. Read More

View Article

Download full-text PDF

Source

High tolerance to instrument drifts by differential chemical isotope labeling LC-MS: A case study of the effect of LC leak in long-term sample runs on quantitative metabolome analysis.

J Mass Spectrom 2020 Jun 11:e4589. Epub 2020 Jun 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Metabolomics study of a biological system often involves the analysis of many comparative samples over a period of several days or weeks. This process of long-term sample runs can encounter unexpected instrument drifts such as small leaks in liquid chromatography-mass spectrometry (LC-MS), degradation of column performance, and MS signal intensity change. A robust analytical method should ideally tolerate these instrumental drifts as much as possible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jms.4589DOI Listing

Antibodies against three novel peptides in early axial spondyloarthritis patients from two independent cohorts.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Hasselt, Belgium.

Objective: The aim of this study was to identify novel autoantibodies in axial spondyloarthritis (axSpA) and determine their diagnostic potential in early axSpA patients and controls from two independent cohorts.

Methods: An axSpA cDNA phage display library was used to screen for novel immunoglobulin G (IgG) antibodies in plasma of early axSpA patients. Presence of these antibodies against novel Hasselt University (UH)-axSpA peptides was determined in 76 early axSpA patients, 75 non-specific chronic low back pain (CLBP) controls, 60 rheumatoid arthritis (RA) patients and 94 healthy controls (HC) from the UH cohort using enzyme-linked immunosorbent assays (ELISA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.41427DOI Listing

Efficacy and Safety of Upadacitinib Monotherapy in Methotrexate-naïve Patients with Moderately to Severely Active Rheumatoid Arthritis (SELECT-EARLY): A Randomized, Double-blind, Active-comparator, Multi-center, Multi-country Trial.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Stanford University, Palo Alto, CA, USA.

Objective: The SELECT-EARLY trial studied the effect of upadacitinib, an oral, reversible, JAK inhibitor, as monotherapy in patients with predominantly early rheumatoid arthritis who are naïve or have limited exposure to methotrexate.

Methods: Patients were randomized (n=947, 1:1:1) to once-daily upadacitinib (15mg or 30mg) or weekly methotrexate (7.5-20mg/week) for 24 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.41384DOI Listing

Impeding factors of early rehabilitation postoperatively after rheumatoid toe arthroplasty: a single-center retrospective cohort study.

JA Clin Rep 2020 Jul 7;6(1):50. Epub 2020 Jul 7.

Department of Anesthesiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan.

Introduction: Previous studies explored the benefits related to early ambulation postoperatively, but few focused on patients with rheumatoid arthritis (RA). We retrospectively evaluated the incidence and predictors of the inability to begin walking on the first postoperative day (POD) after toe arthroplasty for rheumatoid arthritis.

Methods: RA patients who underwent toe arthroplasty at one hospital were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40981-020-00356-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340694PMC

The genetics of rheumatoid arthritis.

Authors:
Laura E Dedmon

Rheumatology (Oxford) 2020 Jul 8. Epub 2020 Jul 8.

UCL Medical School, London, UK.

RA is a chronic systemic inflammatory disease that primarily affects the small joints of the hands and feet, and results in a mean reduction in life expectancy of 3-10 years. RA is a multigene disorder with a substantial genetic component and a heritability estimate of 60%. Large-scale Genome-Wide Association Studies (GWAS) and meta-analyses have revealed common disease-associated variants in the population that may contribute cumulatively to RA pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/keaa232DOI Listing

The Validity and Sensitivity of Rheumatoid Arthritis Pain Scale on a Different Ethnic Group From Indian Rheumatoid Arthritis Patients.

Arch Rheumatol 2020 Mar 6;35(1):90-96. Epub 2019 Nov 6.

Department of General Medicine, K C G M C, Karnal, India.

Objectives: This study aims to assess pain in rheumatoid arthritis (RA) patients by using Rheumatoid Arthritis Pain Scale (RAPS) and to find its correlation with Disease Activity Score 28 (DAS28) and Clinical Disease Activity Index (CDAI).

Patients And Methods: The study included 100 RA patients (23 males, 77 females; mean age 43.22 years; range, 19 to 72 years) who were subjected to RAPS questionnaire for pain assessment and DAS28 and CDAI for disease activity assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5606/ArchRheumatol.2020.7348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322297PMC

First-year drug therapy of new-onset rheumatoid and undifferentiated arthritis: a nationwide register-based study.

BMC Rheumatol 2020 3;4:34. Epub 2020 Jul 3.

Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland.

Background: In this retrospective cohort study, we evaluated the drug therapies used for early rheumatoid (RA) and undifferentiated (UA) arthritis patients.

Methods: From a nationwide register maintained by the Social Insurance Institution, information on sex, date of birth, and date of special medicine reimbursement decision for all new Finnish RA and UA patients between 2011 and 14 were collected, and their DMARD (Disease Modifying Antirheumatic Drug) purchases during the first year after the diagnosis were analyzed.

Results: A total of 7338 patients with early RA (67. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s41927-020-00127-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333434PMC

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.

Sci Adv 2020 Jun 26;6(26):eaba4353. Epub 2020 Jun 26.

Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, La Jolla, CA 92093, USA.

Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted approaches could potentially be combined with DMARDs to improve control of RA without increasing immunosuppression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aba4353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319753PMC

Sulfasalazine in dermatology: A lesser explored drug with broad therapeutic potential.

Int J Womens Dermatol 2020 Jun 13;6(3):191-198. Epub 2020 Feb 13.

Department of Dermatology, Venereology & Leprology, Maulana Azad Medical College, New Delhi, India.

Sulfasalazine is an aminosalicylate primarily used in the treatment of rheumatoid arthritis and ulcerative colitis. Its immunomodulatory, anti-inflammatory, and antiproliferative properties make it a potential therapeutic option for various dermatological disorders. Owing to its wide range of effects, it is often used off-label in dermatological diseases, such as alopecia areata, psoriasis and psoriatic arthritis, lichen planus, and pemphigus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijwd.2020.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330441PMC

Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge.

Mol Ther Methods Clin Dev 2020 Sep 6;18:215-229. Epub 2020 Jun 6.

Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China.

Circular RNAs (circRNAs) are a new class of noncoding single-stranded RNAs that differ from linear microRNAs (miRNAs), since they form covalently closed loop structures without free 3' poly(A) tails or 5' caps. circRNAs are the competitive endogenous RNAs (ceRNAs) by binding to miRNA through miRNA response elements (MREs) (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtm.2020.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326721PMC
September 2020

Whole-Body Magnetic Resonance Imaging Assessment of Joint Inflammation in Rheumatoid Arthritis-Agreement With Ultrasonography and Clinical Evaluation.

Front Med (Lausanne) 2020 19;7:285. Epub 2020 Jun 19.

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark.

To compare joint inflammation seen by whole-body magnetic resonance imaging (WBMRI), with "whole-body" ultrasound and clinical assessments, in patients with active rheumatoid arthritis (RA) before and during tumor necrosis factor-inhibitor (TNF-I, adalimumab) treatment. In 18 patients with RA, clinical assessment for joint tenderness and swelling, WBMRI, and ultrasound were obtained at baseline and week 16. Wrist, metacarpophalangeal (MCP) and proximal interphalangeal (PIP), elbow (except for WBMRI), shoulder, knee, ankle, and metatarsophalangeal joints were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2020.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317301PMC

Osteoclast Signal Transduction During Bone Metastasis Formation.

Front Cell Dev Biol 2020 19;8:507. Epub 2020 Jun 19.

Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Osteoclasts are myeloid lineage-derived bone-resorbing cells of hematopoietic origin. They differentiate from myeloid precursors through a complex regulation process where the differentiation of preosteoclasts is followed by intercellular fusion to generate large multinucleated cells. Under physiological conditions, osteoclastogenesis is primarily directed by interactions between CSF-1R and macrophage colony-stimulating factor (M-CSF, CSF-1), receptor activator of nuclear factor NF-κB (RANK) and RANK ligand (RANKL), as well as adhesion receptors (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcell.2020.00507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317091PMC

Invasive Thymoma with Right Upper Lobe Endobronchial Lesion and Autoimmune Enteropathy.

Case Rep Pulmonol 2020 20;2020:6396915. Epub 2020 Jun 20.

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Thymomas are slow-growing neoplasia arising from the epithelial cells of the thymus that usually present with respiratory symptoms, superior vena cava syndrome, or parathymic syndromes. Approximately 30% of thymomas develop myasthenia gravis. An additional 5% of patients with thymomas have other systemic syndromes, including rheumatoid arthritis, thyroiditis, red cell aplasia, systemic lupus erythematosus, and Cushing syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/6396915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322609PMC

Comparative effectiveness of biological medicines in rheumatoid arthritis: systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.

BMJ 2020 07 7;370:m2288. Epub 2020 Jul 7.

Drug Assessment Department, Institute for Quality and Efficiency in Health Care, Im Mediapark 8, Cologne 50670, Germany

Objective: To assess the comparative effectiveness of biological medicines in rheumatoid arthritis in sufficiently similar patient populations, based on the current definitions of key outcomes.

Design: Systematic review and network meta-analysis including aggregate results from reanalysed individual patient data.

Data Sources: Clinical study reports and aggregate results from reanalyses of individual patient data on key outcomes for rheumatoid arthritis provided by study sponsors for studies conducted up to 2017, and several databases and registries from inception up to February 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmj.m2288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338922PMC