65,689 results match your criteria Rheumatic diseases clinics of North America[Journal]


F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach.

Mol Pharm 2018 Dec 14. Epub 2018 Dec 14.

Antibody fragment F8- mediated Interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin (ED-A). In this study, in-vivo biodistribution and arthritis targeting of radiolabeled F8-IL10 were investigated in RA patients, followed by further animal studies. Read More

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December 2018

Association of good oncological response to therapy with the development of rheumatic immune-related adverse events following PD-1 inhibitor therapy.

Int J Rheum Dis 2018 Nov 22. Epub 2018 Nov 22.

Department of Rheumatology, Austin Health, Melbourne, VIC, Australia.

Aim: To investigate whether any patient or treatment characteristics are associated with the development of rheumatic immune-related adverse events (irAEs) following programmed cell death protein 1 (PD-1) inhibitor therapy for cancer.

Method: This was a retrospective chart review of all patients who were dispensed nivolumab or pembrolizumab at a single center before 1 January, 2017, with follow-up until 1 July, 2017. Patients with any diagnosis of a non-cutaneous irAE were identified, regardless of severity, and rheumatic irAEs were characterized. Read More

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November 2018

Association of Asian mitochondrial DNA haplogroup B with new development of knee osteoarthritis in Koreans.

Int J Rheum Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Aim: The aim of this study was to determine which mitochondrial DNA (mtDNA) haplogroup is associated with new development of knee osteoarthritis (OA).

Methods: Epidemiologic data and knee radiographs with the Kellgren-Lawrence (K/L) score of the Ansung cohort study were prospectively obtained from the 2nd (2005-2006) and 6th follow-up periods (2013-2014). The mtDNA was analyzed by multiplex mutagenetically separated polymerase chain reaction to determine Asian mtDNA haplogroups (M, G, D, D4, D5, M7, M8, M9, M10, N, A, N9, R, F and B). Read More

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December 2018

Polyautoimmunity in rheumatological conditions.

Int J Rheum Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Co-occurrence of autoimmune diseases (ADs) within an individual is postulated to be a frequent phenomenon in rheumatic diseases. Similar clinical signs and symptoms, pathophysiological mechanisms, genetic factors within autoimmune diseases and aggregation of diverse ADs within families sustain the theory of shared pathogenesis of several ADs (autoimmune tautology). Polyautoimmunity (PA) is defined as the presence of more than one autoimmune disease in a single patient. Read More

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December 2018

Application and preliminary validation of the hip inflammation MRI scoring system (HIMRISS) in spondyloarthritis.

Int J Rheum Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Immunology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Aims: Spondyloarthritis (SpA) is an inflammatory rheumatic disease and hip involvement often results in severe deformities and functional impairment. Magnetic resonance imaging (MRI) is a powerful imaging tool for detecting early hip lesions in SpA. The aims of this study are to apply the hip inflammation MRI scoring system (HIMRISS) in SpA patients and to evaluate its reproducibility and validity. Read More

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December 2018

Quantification of rheumatic mitral stenosis severity with three-dimensional vena contracta area.

Echocardiography 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Marmara University Medical Center, Istanbul, Turkey.

Introduction: Rheumatic mitral stenosis (MS) is an important health issue in developing countries. Assessment of the correct mitral valve area (MVA) is essential for the timing of intervention. Most of the parameters for the assessment of rheumatic MS are derived from Two-dimensional (2D) echocardiography. Read More

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December 2018

Off-label use of tocilizumab to treat non-juvenile idiopathic arthritis in pediatric rheumatic patients: a literature review.

Pediatr Rheumatol Online J 2018 Dec 14;16(1):79. Epub 2018 Dec 14.

Department of Rheumatology, Ajou University of medical school, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Republic of Korea.

Tocilizumab, an anti-interleukin-6 (IL-6) agent, is indicated as a treatment for several autoimmune or inflammatory diseases, including rheumatoid arthritis and juvenile idiopathic arthritis (JIA). IL-6 plays roles in both immune system dysregulation and inflammation, and thus efforts to extend the utility of tocilizumab in patients with autoinflammatory conditions are ongoing. Here, we survey the literature on the off-label use of tocilizumab in patients with juvenile-onset rheumatic diseases including juvenile systemic lupus erythematosus (SLE), juvenile dermatomyositis (DM), vasculitis, juvenile scleroderma, and other autoinflammatory diseases. Read More

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December 2018

Silent patent ductus arteriosus incidentally found before balloon mitral valvotomy for severe rheumatic mitral stenosis.

J Cardiol Cases 2016 Jun 2;13(6):165-168. Epub 2016 Mar 2.

Department of Cardiology, Sanjay Gandhi PGIMS, Lucknow, India.

Rheumatic heart disease (RHD) and congenital heart disease (CHD) rarely co-exist in the same patient. However, such associations are not unknown in areas where RHD is endemic. We report a rare combination of severe rheumatic mitral stenosis, severe pulmonary artery hypertension (PAH), and an incidental clinically silent patent ductus arteriosus (PDA). Read More

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Anakinra in Still's disease: a profile of its use.

Drugs Ther Perspect 2018 31;34(12):543-553. Epub 2018 Oct 31.

Springer, Private Bag 65901, Mairangi Bay, 0754 Auckland, New Zealand.

The EU indication for anakinra has been extended to include Still's disease, a serious rare inflammatory disorder of unknown aetiology that comprises adult-onset Still's disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA). As activated interleukin-1 pathways are associated with the systemic manifestations of these disorders, targeted treatment with anakinra, an interleukin-1 inhibitor, has been investigated. Across clinical and real-world studies in patients with AOSD and SJIA, treatment with anakinra achieved clinical remission/response, provided rapid and sustained improvements in systemic and laboratory manifestations, and allowed the use of corticosteroid- and disease-modifying anti-rheumatic drugs (DMARD) to be reduced or discontinued. Read More

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October 2018
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Transcatheter Valve Replacement in Asia Pacific: Current Practice and Perspectives.

J Am Coll Cardiol 2018 Dec;72(24):3189-3199

Interventional Cardiology Unit, GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy. Electronic address:

Although the field of transcatheter therapies for valvular heart disease (VHD) is continuously expanding in western countries, uptake of this treatment in Asia has been slow, mainly due to the high cost of devices, need for specific training programs, and lack of specialized heart teams and dedicated structures. Moreover, anatomic considerations of the Asian population, such as smaller aorta and peripheral vessel size, high prevalence of bicuspid aortic valves, high calcium burden of stenotic aortic valve leaflets, low coronary ostia, and high prevalence of rheumatic etiology, might raise concerns about feasibility, risk of procedural complications, prosthesis durability, and long-term outcomes after transcatheter treatment of VHD. Asia Pacific and China's medical communities and manufacturer companies are setting up to address this unmet clinical need. Read More

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December 2018

Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Division of Rheumatology, Department of Medicine, University of Debrecen, Faculty of Medicine, Debrecen, Hungary. Electronic address:

Several inflammatory, proteolytic, angiogenic and bone-associated factors play a role in the development of autoimmune, accelerated atherosclerosis in rheumatic diseases. Some of these may serve as biomarkers of vascular pathology and may be useful in the follow-up of vascular damage and outcome. Multi-biomarker profiles rather than a single markers would likely be optimal in this respect. Read More

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December 2018

A dual role of TGF-β in human osteoclast differentiation mediated by Smad1 versus Smad3 signaling.

Immunol Lett 2018 Dec 10. Epub 2018 Dec 10.

Rheumatology, College of Medicine, Korea University, Seoul, South Korea. Electronic address:

TGF-β1 is highly expressed in the synovial tissue of patients with rheumatoid arthritis and is known as a cytokine that plays an important role in tissue repair and immune cell regulation. However, the role of TGF-β1 is still unclear in osteoclastogenesis. In this study, we examined the effect of TGF-β1 on osteoclast differentiation and the underlying mechanism using healthy human peripheral blood monocytes. Read More

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December 2018

[A Case of Rheumatoid Arthritis Developed during Treatment with Nivolumab for Renal Cell Carcinoma].

Hinyokika Kiyo 2018 Oct;64(10):397-401

The Department of Urology, Nara Medical University.

A 66-year-old man underwent nephrectomy for right renal cell carcinoma (cT3bNOMl (PUL)). Thereafter, he was treated with sunitinib for lung metastasis as the first-line therapy for 5 months and then axitinib as the second-line therapy for 2 months. Because lung metastasis progressed despite molecular targeted therapies, nivolumab was used as the third-line treatment. Read More

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October 2018

Venous Thromboembolism Prophylaxis and Risk in the Inpatient and Outpatient Continuum of Care Among Hospitalized Acutely Ill Patients in the US: A Retrospective Analysis.

Adv Ther 2018 Dec 12. Epub 2018 Dec 12.

Novosys Health, Green Brook, NJ, USA.

Introduction: Venous thromboembolism (VTE) is a leading cause of preventable morbidity and mortality among hospitalized patients in the US. The objectives of this study were to examine VTE prophylaxis patterns and risk for VTE events during hospitalization and post-discharge among patients hospitalized for acute illnesses in the US.

Methods: Acutely ill hospitalized patients were identified from the MarketScan databases (January 1, 2012-June 30, 2015). Read More

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December 2018

25-Hydroxyvitamin D serum levels in rheumatic female patients in southeast Spain: The paradigm of daily optimal sunshine levels and inadequate vitamin D status.

Endocrinol Diabetes Nutr 2018 Dec 9. Epub 2018 Dec 9.

Scientific Direction, Gador SA, Buenos Aires, Argentina.

Background: Almeria is a region in southeast Spain with optimal sunlight levels, along with low pluvial and pollution rates. If exposure to sunlight is sufficient to maintain adequate levels of vitamin D (25OHD), this population should display high serum levels.

Objectives: To describe 25OHD serum status in women from Almeria and evaluate the impact of long sunlight exposure along the seasons on 25OHD. Read More

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December 2018

Whole body and partial body cryotherapies - lessons from human practice and possible application for horses.

BMC Vet Res 2018 Dec 12;14(1):394. Epub 2018 Dec 12.

Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, SGGW, Nowoursynowska 159c, Warsaw, Poland.

Whole body and partial body cryotherapies (WBC and PBC) have been successfully used in human medicine, and currently also are being proposed in veterinary practice.In horses, only the partial body cryotherapy provided in cryosauna is considered, due to the technical conditions. These therapies have been dedicated to human patients with rheumatic and inflammatory diseases as well as an assistance during training in athletes. Read More

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December 2018

Potential role of platelets for atherosclerotic events in rheumatoid arthritis.

FEBS Open Bio 2018 Dec 6;8(12):1888-1896. Epub 2018 Nov 6.

Center for Gender-Specific Medicine Biomarkers Unit Istituto Superiore di Sanità Rome Italy.

Rheumatoid arthritis (RA) is a chronic inflammatory disease with increased risk of cardiovascular events and mortality that can be attributed to accelerated atherosclerosis. This pilot study aimed to investigate if changes in blood parameters were compatible with atherosclerotic events in RA patients. To this aim, 45 RA women (aged more than 18 years), and 25 age and gender-matched healthy donors (HD) were included. Read More

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December 2018

Anti-cytokine agents for anhedonia: targeting inflammation and the immune system to treat dimensional disturbances in depression.

Ther Adv Psychopharmacol 2018 Dec 19;8(12):337-348. Epub 2018 Nov 19.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada Brain and Cognition Discovery Foundation, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada Department of Psychiatry, University of Toronto, Toronto, ON, Canada Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

The etiology of mood disorders is mechanistically heterogeneous, underscoring the need for a dimensional approach to identify and develop targeted treatments in psychiatry. Accumulating evidence implicates inflammation as an important contributor to the pathophysiology of depression and presents the immune system as a viable therapeutic target that may be more proximate to the pathogenic nexus of brain-based disorders in specific subpopulations. Anhedonia is a transdiagnostic (e. Read More

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December 2018
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Granuloma annulare development in a patient with rheumatoid arthritis treated with tocilizumab: case-based review.

Rheumatol Int 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine, Rheumatology Clinic, Medical School, University of Ioannina, 45110, Ioannina, Greece.

Granuloma annulare (GA) is the most common non-infectious disease. Despite the fact that it is a benign disease, it can be associated with a variety of disorders and certain drugs including biological disease-modifying anti-rheumatic drugs (bDMARDs). A 50-year-old man with a history of rheumatoid arthritis refractory to methotrexate, hydroxychloroquine and infliximab was treated with tocilizumab (TCZ), an interleukin-6 receptor antagonist, 162 mg subcutaneously every week. Read More

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December 2018

[Investigation of the diagnostic value of anti-dense fine speckled 70/lens epithelium derived growth factor p75 autoantibody for autoimmune diseases].

Mikrobiyol Bul 2018 Oct;52(4):413-424

Ankara Training and Research Hospital, Clinic of Medical Microbiology, Ankara, Turkey.

Antinuclear antibodies (ANA) are the autoantibodies that are produced against nuclear antigens in the cell nucleus and/or cytoplasm, and are one of the important diagnostic criteria in systemic autoimmune rheumatic diseases (SARD). Until today, several methods have been developed for detecting ANA's. However, indirect immunofluorescence (IIF) technique, that is also known as one of the oldest methods, is still the most commonly used one. Read More

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October 2018

Alcohol intake and risk of systemic lupus erythematosus: a Mendelian randomization study.

Authors:
S C Bae Y H Lee

Lupus 2018 Dec 12:961203318817832. Epub 2018 Dec 12.

2 Department of Rheumatology, Korea University College of Medicine, Seoul, Korea.

Objectives: This study aimed to examine whether alcohol intake is causally associated with systemic lupus erythematosus (SLE).

Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and an SLE GWAS consisting of 1311 SLE and 1783 control subjects of European descent as the outcome. Read More

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December 2018
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Reliability of OMERACT ultrasound elementary lesions in gout: results from a multicenter exercise.

Rheumatol Int 2018 Dec 11. Epub 2018 Dec 11.

Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Echeverria 955, Buenos Aires, C1428DQG, Argentina.

The aim of this study was to evaluate the reliability of the outcome measures in rheumatology (OMERACT) definitions for ultrasound (US) elementary lesions in gout through an image reading exercise. Images from patients with gout (static images and videos) were collected. As an initial step, we carried out a image reading exercise within the experts of the Pan-American League of Associations for Rheumatology (PANLAR) US Study Group (n = 16). Read More

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December 2018

A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination.

Blood 2018 Dec 11. Epub 2018 Dec 11.

School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom;

The Recombination Activating Genes, RAG1 and RAG2, are essential for V(D)J recombination and adaptive immunity. Mutations in these genes often cause immunodeficiency, the severity of which reflects the importance of the altered residue(s) during recombination. Here, we describe a novel RAG1 mutation that causes immunodeficiency in an unexpected way: The mutated protein severely disrupts binding of the accessory protein, HMGB1. Read More

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December 2018

Multiple coronary fistula formation associated with a huge left atrial thrombus in rheumatic mitral valve stenosis.

J Cardiol Cases 2014 Mar 3;9(3):124-126. Epub 2014 Jan 3.

Atherosclerosis Prevention Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Acquired fistulous communication with the left atrial (LA) chamber has been described in the presence of LA mural thrombus in patients with rheumatic mitral stenosis (MS). Hereby, we present the case of a 74-year-old man with rheumatic MS and a huge LA thrombus found in echocardiography. Coronary angiography revealed an extensive fistula formation feeding mainly from the atrial branches of left circumflex and right coronary arteries and draining into the LA chamber. Read More

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Anaphylactic shock associated with intravenous amiodarone.

J Cardiol Cases 2014 Feb 12;9(2):61-62. Epub 2013 Dec 12.

Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey.

A 64-year-old woman was admitted to our emergency department with shortness of breath and palpitation which started 2 h before her admission. She had a history of rheumatic mitral valve disease and was on drug treatment with warfarin and metoprolol. The patient was orthopneic, blood pressure was 108/68 mmHg with an irregular pulse with a heart rate of 158 beats per minute, and respiratory rate was 23 times per minute. Read More

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February 2014
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Pathological evaluation of massive left atrial calcification 35 years after mitral-aortic valve replacement.

J Cardiol Cases 2015 Feb 31;11(2):44-47. Epub 2014 Oct 31.

Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Massive calcification of the left atrium is an uncommon complication of long-standing rheumatic valve disease, and is frequently revealed in patients with a previous operation on the mitral valve. An 84-year-old woman, who had a history of rheumatic valvulopathy and mitral-aortic valve replacement surgery 35 years previously, was admitted to our hospital due to congestive heart failure. Chest X-ray showed severe cardiomegaly with rim of calcification outlining the enlarged left atrium. Read More

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February 2015

Transcatheter mitral paravalvular leakage closure: A beautiful last resort.

J Cardiol Cases 2014 Oct 23;10(4):147-149. Epub 2014 Jul 23.

Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.

We describe a case of a 54-year-old patient with rheumatic heart valve disease who was treated with double valve replacement (both aortic and mitral) twice. Two months after the second operation she developed a severe mitral paravalvular leakage (PVL) leading to cardiogenic shock for which she was hospitalized in the intensive care unit. Multiple weaning efforts proved to be unsuccessful because of persistent hemodynamic instability caused by the severe PVL. Read More

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October 2014

Septic embolization of left and right coronary arteries resulting in sudden death: A rare complication of infective endocarditis.

J Cardiol Cases 2014 Jul 1;10(1):22-24. Epub 2014 May 1.

Teaching Hospital Kandy, Kandy, Sri Lanka.

Bacterial endocarditis gives rise to a variety of complications due to local tissue damage, immunological phenomena, and embolic phenomena. Only a small number of cases of coronary embolization have been reported in infective endocarditis patients. This is a case of subacute bacterial endocarditis in a postpartum mother complicated by fatal left and right coronary artery embolization. Read More

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'New World' imaging for an 'Old World' disease: Use of cardiac magnetic resonance imaging and 3D transesophageal echocardiography in severe rheumatic mitral valve disease.

J Cardiol Cases 2012 Jul 31;6(1):e4-e7. Epub 2012 Mar 31.

Cardiology Department, Dorset Heart Centre, Royal Bournemouth Hospital, Bournemouth, UK.

We report a case of severe rheumatic mixed mitral valve disease in a young adult male where a combination of imaging techniques was utilized. We demonstrate that cardiac magnetic resonance imaging may be used as an alternative imaging modality in patients not suitable for the more established techniques of transthoracic and transesophageal echocardiography. Additionally, the use of 3D-transesophageal imaging offered the cardiothoracic surgeon additional anatomical information at the time of mitral valve replacement. Read More

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Fungal endocarditis involving rheumatic mitral valve in a young man.

J Cardiol Cases 2011 Aug 25;4(1):e55-e57. Epub 2011 Jun 25.

Gazi University Medical Faculty, Department of Cardiology, Ankara, Turkey.

Fungal endocarditis is a relatively rare condition with particular difficulties in diagnosis and treatment. These difficulties lead to higher rates of mortality and morbidity. We report the successful treatment of a patient with rheumatic mitral valve who had fungal endocarditis due to Cushing syndrome caused by iatrogenic corticosteroid supplement. Read More

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Gelatin sponge mimicking left atrial clot in rheumatic mitral stenosis.

J Cardiol Cases 2011 Feb 8;3(1):e43-e45. Epub 2010 Oct 8.

Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences & Research, Bangalore, India.

We report the case of a 23-year-old female who underwent balloon mitral valvotomy for severe symptomatic mitral stenosis. Following septal puncture, the patient developed cardiac tamponade, which warranted sternotomy to suture the rent in the inferior vena cava-right atrial junction. The postoperative echocardiogram revealed nonhomogenous irregular opacities within the left atrium suggesting the possibility of thrombus formation. Read More

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February 2011

Adalimumab efficacy for venous thrombosis in typical sites in Behçet's syndrome.

Arthritis Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurosciences, Psychology, Pharmacology and Child Health (NEUROFARBA), University of Firenze, Italy.

In our work entitled "Adalimumab-based treatment versus DMARDs for venous thrombosis in Behçet syndrome. A retrospective study of 70 patients with vascular involvement" , we showed that Adalimumab (ADA)-based regimen is more effective and rapid than disease modifying anti-rheumatic drugs (DMARDs) in inducing resolution of venous thrombosis in patients with Behçet syndrome (BS), also allowing significant reduction of steroid exposure. This article is protected by copyright. Read More

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December 2018
2 Reads

Outcome of pregnancy in women with psoriatic arthritis compared to healthy controls.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Centre for Prognosis Studies in the Rheumatic Diseases, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Objectives: The mean age at onset of psoriatic arthritis (PsA) ranges between the 4th-6th decades of life. However, little is known about fertility and pregnancy outcome in PsA patients. The aim of this study was to examine whether fertility and pregnancy outcome of PsA patients are different from healthy controls and to evaluate PsA and psoriasis disease activity perception during pregnancy and the year postpartum. Read More

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December 2018
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The temporal relationship between cancer and adult onset anti-transcriptional intermediary factor 1 antibody-positive dermatomyositis.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.

Objectives: To characterize the 10 year relationship between anti-transcriptional intermediary factor 1 antibody (anti-TIF1-Ab) positivity and cancer onset in a large UK-based adult DM cohort.

Methods: Data from anti-TIF1-Ab-positive/-negative adults with verified diagnoses of DM from the UK Myositis Network register were analysed. Each patient was followed up until they developed cancer. Read More

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December 2018
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Kidney toxicity and response of selenium containing protein-glutathione peroxidase (Gpx3) to CdTe QDs on different levels.

Toxicol Sci 2018 Dec 10. Epub 2018 Dec 10.

School of Environmental Science and Engineering, Shandong University, China -America CRC for Environment & Health, Shandong Province, 72# Jimo Binhai Road, Qingdao, Shandong, P.R. China.

The toxic mechanism of cadmium-quantum dot (Cd-QDs) to organisms is still debating. In this paper, it was found that Cd-QDs could induce adverse effects to kidney by entering into cells in a time and dose manner and disturbing the redox balance in vivo. As a selenium containing protein, glutathione peroxidase3 (Gpx3) plays a crucial role in maintaining the balance of redox system. Read More

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December 2018

European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides - the SHARE initiative.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Paediatric Rheumatology, Alder Hey Children's Hospital, Liverpool, UK.

Objectives: The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care for children with rheumatic diseases. Systemic vasculitides are very rare in children. Consequently, despite recent advances, paediatric-specific information is sparse. Read More

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December 2018
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European consensus-based recommendations for the diagnosis and treatment of Kawasaki disease - the SHARE initiative.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Objectives: The European Single Hub and Access point for paediatric Rheumatology in Europe initiative aimed to optimize care for children with rheumatic diseases. Kawasaki disease (KD) is the most common cause of acquired heart disease in children and an important cause of long-term cardiac disease into adulthood. Prompt diagnosis and treatment of KD is difficult due to the heterogeneity of the disease but is crucial for improving outcome. Read More

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December 2018
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Mobile apps, wearables and the future of technology in rheumatic disease care.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Academic Rheumatology, King's College London, London, UK.

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December 2018

A rare cause of ischemic stroke: cardiac myxoma. Case report and review of literature.

Rom J Morphol Embryol 2018 ;59(3):903-909

Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania;

A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosis and produced severe pulmonary hypertension. Read More

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January 2018

Involvement of inflammatory responses in the early development of calcific aortic valve disease: lessons from statin therapy.

Anim Cells Syst (Seoul) 2018 28;22(6):390-399. Epub 2018 Sep 28.

Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.

Calcific aortic valve disease (CAVD) is the most common degenerative heart valve disease. Among the many risk factors for this disease are age, hypercholesterolemia, hypertension, smoking, type-2 diabetes, rheumatic fever, and chronic kidney disease. Since many of these overlap with risk factors for atherosclerosis, the molecular and cellular mechanisms of CAVD development have been presumed to be similar to those for atherogenesis. Read More

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September 2018

Budget impact analysis of sarilumab for the treatment of rheumatoid arthritis in patients with an inadequate response to conventional synthetic DMARD or TNF inhibitor therapies.

Clinicoecon Outcomes Res 2018 16;10:805-819. Epub 2018 Nov 16.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA,

Objective: To estimate the 5-year budget impact (BI) on a US health plan of introducing sarilumab - a human immunoglobulin G1 anti-IL-6 receptor α monoclonal antibody - as combination treatment with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or monotherapy in patients with moderate-to-severe rheumatoid arthritis (RA).

Methods: BI analysis was conducted from a commercial payer perspective. Treatment-eligible populations included adult patients with moderate-to-severe RA and inadequate response (IR) to csDMARDs or tumor necrosis factor (TNF)-α inhibitors-IR. Read More

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November 2018

[Cardiomegalia gigante].

Gac Med Mex 2018 ;154(6):727-728

Universidad de Castilla-La Mancha, Hospital General Universitario de Albacete; Centro de Salud de Villanueva de la Jara. Castilla-La Mancha, España.

Eighty-year old woman with a medical history of arterial hypertension, rheumatic valvular heart disease with mitral and aortic valve replacement, chronic atrial fibrillation and congestive heart failure dependent on domiciliary chronic oxygen for 17 daily hours. The reason for arrival to the hospital was a stroke of cardioembolic etiology. Read More

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January 2018

The Knee Osteoarthritis Grading System for Arthroplasty.

J Arthroplasty 2018 Nov 15. Epub 2018 Nov 15.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom.

Background: The aim of this study is to validate the Knee Osteoarthritis Grading System (KOGS) of progressive osteoarthritic degeneration for the tri-compartmental knee. This system defines the site and severity of osteoarthritis to determine a specific knee arthroplasty.

Methods: The radiographic sequence for KOGS includes standing coronal (anteroposterior), lateral, 30° skyline patella, 15° and 45° Rosenberg and stress views in 20° of flexion. Read More

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November 2018
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New Concepts to Reduce Glucocorticoid Toxicity.

Joint Bone Spine 2018 Dec 5. Epub 2018 Dec 5.

Schlosspark-Klinik Charité University Medicine Berlin, Heubnerweg 2, 14059 Berlin, Germany.

70 years after their first use, low-dose glucocorticoids are a common part of pharmacological rheumatoid arthritis treatment. This is due to their well-proven capacities in symptom severity and disease activity reduction, in particular when combined with a disease-modifying anti-rheumatic drug, such as methotrexate. Nevertheless, glucocorticoid administration, in long-term especially, is also seen critically because of its potential adverse conditions. Read More

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December 2018
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Update on the epidemiology, risk factors, and disease outcomes of axial spondyloarthritis.

Best Pract Res Clin Rheumatol 2018 04 16;32(2):241-253. Epub 2018 Nov 16.

Rheumatology Department, Cochin Hospital, Paris, France; Inserm (U1153), Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France.

Axial spondyloarthritis (axSpA) is the prototype of a class of a rheumatic chronic inflammatory disease named spondyloarthritis (SpA). The prevalence of axSpA ranges between 0.1% and 1. Read More

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Epidemiology of rheumatic and musculoskeletal diseases.

Best Pract Res Clin Rheumatol 2018 04;32(2):167-168

Instituto de Salud Musculoesquelética, Madrid, Spain. Electronic address:

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Correction to: Incidence of giant cell arteritis in Western Norway 1972-2012: a retrospective cohort study.

Arthritis Res Ther 2018 Dec 7;20(1):271. Epub 2018 Dec 7.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Following publication of the original article [1], the authors reported an error. Read More

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December 2018

Disease course patterns in systemic lupus erythematosus.

Lupus 2018 Dec 8:961203318817132. Epub 2018 Dec 8.

Centre for Prognosis Studies in Rheumatic Diseases, Toronto Lupus Clinic, Toronto, Canada.

Background: Disease activity in systemic lupus erythematosus follows three different courses: long quiescent, relapsing remitting and persistently active. However, the patterns of disease course since diagnosis are not known. This study aimed to assess the prevalence and characteristics of such patterns over 10 years. Read More

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December 2018

A value proposition for trough level-based anti-TNFα drug dosing.

Clin Chim Acta 2018 Dec 3;489:89-95. Epub 2018 Dec 3.

Expert Center Clinical Chemistry Eindhoven, Eindhoven, the Netherlands; Clinical Laboratory, Máxima Medical Center, Veldhoven, the Netherlands.

Treatment of inflammatory bowel diseases and rheumatic disorders with anti-tumor necrosis factor alpha (TNFα) drugs is expensive, while a significant proportion of patients does not show adequate clinical response. Therapeutic drug monitoring (TDM) enables patient-specific anti-TNFα therapy. The role of laboratory tests in clinical care has recently been described in a value proposition framework. Read More

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December 2018
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