1,677 results match your criteria Rheumatic diseases clinics of North America[Journal]


Best Practices and Challenges to the Practice of Rheumatologists.

Rheum Dis Clin North Am 2019 Feb;45(1):xv-xvi

Cedars Sinai Medical Center, David Geffen School of Medicine, University of California-Los Angeles, 8750 Wilshire Boulevard, Suite 350, Beverly Hills, CA 90211, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2018.10.001DOI Listing
February 2019
8 Reads
2.692 Impact Factor

Best Practices and Challenges to the Practice of Rheumatologists.

Rheum Dis Clin North Am 2019 Feb;45(1):xiii-xiv

Director, Division of Rheumatology, Professor of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2018.10.002DOI Listing
February 2019
17 Reads

Challenges in Having an Infusion Center.

Rheum Dis Clin North Am 2019 Feb;45(1):87-100

NewView Medical Consulting, LLC, Santa Clarita, CA 91387, USA. Electronic address:

This article presents a comprehensive overview of the model, care, costs, and considerations necessary in having an outpatient infusion suite in a practice. It provides a real-life assessment of the challenges infusion centers face, including financial and clinical impacts. It is also patient centric, showing how a comfortable patient experience can improve care and increase patient compliance in an outpatient setting. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.012DOI Listing
February 2019
13 Reads

Clinical Trials in Rheumatology.

Rheum Dis Clin North Am 2019 Feb;45(1):79-85

Rheumatology Fellowship Program, Board of Governors, Cedars-Sinai Medical Center, David Geffen School of Medicine Center at UCLA, 8750 Wilshire Boulevard, Suite 350, Beverly Hills, CA 90211, USA. Electronic address:

Clinical trials evaluate the benefits and harms of medical interventions with the ultimate goal of establishing an evidence-based regimen that contributes to clinical decision making. Physicians benefit greatly from clinical research because it provides a greater understanding of epidemiology and health outcomes, and patients are given opportunities to participate in such trials. In this review, we discuss the challenges of conducting clinical trials investigating rheumatic diseases, including that of recruitment, finding the right trial, designing a budget, and performing a study in a timely manner. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.006DOI Listing
February 2019
9 Reads

Challenges to Practicing Pediatric Rheumatology.

Rheum Dis Clin North Am 2019 Feb;45(1):67-78

Pediatric Rheumatology, Hospital for Special Surgery, Hospital for Special Surgery, HSS Main Campus - Main Hospital, 535 East 70th Street 5th Floor, New York, NY 10021, USA.

Pediatric rheumatology is an exciting and rewarding career area. However, challenges when attracting trainees to this field include practice often occurring in smaller groups compared with general pediatrics, available positions requiring relocation, and fluctuation in funding resulting in uncertainty regarding training positions. Having critical mass in pediatric divisions is important to ensure adequate mentoring and people power to produce scholarly work, reduce on-call frequency and mitigate faculty absences that result in unplanned addition of clinical work. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.011DOI Listing
February 2019
27 Reads

The Focused Musculoskeletal Factory.

Rheum Dis Clin North Am 2019 Feb;45(1):53-66

Illinois Bone and Joint Institute, 9000 Waukegan Road, Morton Grove, IL 60053, USA. Electronic address:

Rheumatology has evolved rapidly over the past 20 years. The availability of numerous treatment interventions has dramatically altered patient outcomes and revitalized the specialty. At the same time, the economics of medical practice is challenging the practicing rheumatologist to seek more efficient and more attractive models of care delivery. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.005DOI Listing
February 2019
8 Reads

Challenges of Practicing Rheumatology in a Government Setting: A County Hospital and Veterans Affairs Hospital Perspective.

Rheum Dis Clin North Am 2019 Feb;45(1):39-51

Musculoskeletal Outcomes Research, University of Alabama School of Medicine, 510, 20th Street South, Faculty Office Tower, Room 805 B, Birmingham, AL 35294-000, USA.

In this article, we review the challenges and opportunities afforded by working in a government setting by providing the perspective of the Veterans Affairs experience as well as the county/public hospital experience from Los Angeles County Department of Health Services. This article highlights processes and services that are unique to practicing rheumatology in a government setting, specifically, resource allocation with clinic space and staffing; protocols for access to conventional and biologic disease modifying antirheumatic drugs; and research opportunities for rheumatologists working in a government setting. Our aim is to expand the reader's understanding of this practice setting. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.004DOI Listing
February 2019
7 Reads

Challenges to Practicing Rheumatology in an Academic Center.

Rheum Dis Clin North Am 2019 Feb;45(1):27-37

Division of Rheumatology, Rush University Medical Center, 1611 West Harrison Street Suite 510, Chicago, IL 60612, USA. Electronic address:

Rheumatologists working in academics participate in patient care, teaching, and research. There are several challenges associated with the pursuit of these academic missions, and these are the focus of this article. Additionally, how financial pressures faced by academic institutions have led to greater emphasis on the generation of revenue from clinical activities to the detriment of other academic pursuits is discussed. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.003DOI Listing
February 2019
7 Reads

The Challenges of Approaching and Managing Gout.

Rheum Dis Clin North Am 2019 Feb;45(1):145-157

Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, Suite 848G, New York, NY 10021, USA. Electronic address:

Despite many effective treatments for gout, its management remains a challenge internationally. Options for optimizing gout management may differ in different practice sizes and settings. Gout incidence is rising and it continues to be associated with increased mortality. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.009DOI Listing
February 2019
8 Reads

Workforce Trends in Rheumatology.

Rheum Dis Clin North Am 2019 Feb;45(1):13-26

Division of Rheumatology, Department of Internal Medicine, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan 48109, USA.

The United States is facing a rheumatology provider shortage over the next decade, which will negatively affect care for patients with rheumatic disease across the nation if this deficit is not thoughtfully addressed. The increasing numbers of retiring rheumatology specialists, women entering the workforce, and rheumatology graduates seeking part-time employment were identified as the most significant factors driving the projected decline in supply of providers. The major factors driving the projected increase in demand include an aging and growing population and improved treatment options, both of which increase disease prevalence and the challenge of managing chronic rheumatologic diseases. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.002DOI Listing
February 2019
1 Read

Challenges in Optimizing Medical Education for Rheumatologists.

Rheum Dis Clin North Am 2019 Feb;45(1):127-144

Division of Rheumatology, Allergy, and Immunology, Harvard Medical School, Rheumatology Fellowship Training Program, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

The field of rheumatology has expanded rapidly in recent years, and innovations in immunology, epigenetics, and bone metabolism continue at an astonishing pace. In this fast changing field, optimizing medical education for rheumatologists is vital for maintaining a competent workforce to meet the needs of patients with rheumatic diseases. Several key challenges lie ahead and efforts to optimize medical education for rheumatologists are discussed in this article. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.008DOI Listing
February 2019
6 Reads

Digital Medicine in Rheumatology: Challenges and Opportunities.

Rheum Dis Clin North Am 2019 Feb;45(1):113-126

Crystal Run Health, 95 Crystal Run Road, Middletown, NY 10940, USA.

The exponential growth in technology has had a significant effect on the practice of medicine and will likely transform the practice of medicine. In this article, the authors review select technologies that are already influencing the practice of rheumatology. Social media Websites such as Twitter are now important sources of information and discussion for health care professionals interested in rheumatology. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.010DOI Listing
February 2019
22 Reads
2.692 Impact Factor

Challenges in Implementing Treat-to-Target Strategies in Rheumatology.

Rheum Dis Clin North Am 2019 Feb;45(1):101-112

Division of Rheumatology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA; Division of Pharmacoepidemiology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA.

Despite evidence that treat-to-target (TTT) approaches lead to better disease outcomes in RA, TTT is not widely implemented in rheumatology clinics in North America. This article discusses the barriers (including access to care, patient and physician factors, and systems issues) to implementing TTT in the clinic, and proposes possible solutions and future research directions. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.007DOI Listing
February 2019
7 Reads

The Economics of Rheumatology Practice in the United States.

Authors:
Jon Glaudemans

Rheum Dis Clin North Am 2019 Feb;45(1):1-12

United Rheumatology, 150 Motor Parkway, Suite 108E, Hauppauge, NY 11788, USA. Electronic address:

The current environment shaping rheumatology practice economics, with a focus on revenues, is described. The policies and practices of private and public insurance companies, pharmaceutical manufacturers, and pharmacy benefit managers (PBMs) are summarized, identifying economic implications for rheumatologists. The role of rebates in shaping practice economics is discussed, along with the central role of payers in defining PBM policies. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.09.001DOI Listing
February 2019
1 Read

A Three-Headed Approach to Kidney Involvement in Rheumatic Diseases.

Rheum Dis Clin North Am 2018 11;44(4):xiii-xiv

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2018.08.001DOI Listing
November 2018
7 Reads

Renal Involvement in Rheumatic Diseases.

Rheum Dis Clin North Am 2018 11;44(4):xi

Director, Division of Rheumatology, Professor of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2018.08.002DOI Listing
November 2018
3 Reads

Renal Manifestations of Inflammatory Bowel Disease.

Rheum Dis Clin North Am 2018 11 7;44(4):699-714. Epub 2018 Sep 7.

Nephropathology, Arkana Laboratories, 10810 Executive Center Drive, Suite 100, Little Rock, AR 72211, USA.

Renal and urinary involvement has been reported to occur in 4% to 23% of inflammatory bowel disease (IBD) patients. Parenchymal renal disease is rare and most commonly affects glomerular and tubulointerstitial compartments. The most common findings on renal biopsy of IBD patients are IgA nephropathy and tubulointerstitial nephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.007DOI Listing
November 2018
24 Reads

Autoimmune Kidney Diseases Associated with Chronic Viral Infections.

Rheum Dis Clin North Am 2018 11 7;44(4):675-698. Epub 2018 Sep 7.

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, 55 Fruit Street, GRB 7, Boston, MA 02114, USA. Electronic address:

Autoimmune kidney diseases triggered by viruses are an important cause of kidney disease in patients affected by chronic viral infection. Hepatitis B virus (HBV) infection is associated with membranous nephropathy and polyarteritis nodosa. Hepatitis C virus (HCV) infection is a major cause of cryoglobulinemic glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.006DOI Listing
November 2018
3 Reads

Anti-Glomerular Basement Membrane Disease.

Rheum Dis Clin North Am 2018 11 7;44(4):651-673. Epub 2018 Sep 7.

Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK; Vasculitis Clinic, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK. Electronic address:

Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune small vessel vasculitis characterized by autoreactivity to antigens in type IV collagen chains expressed in glomerular and alveolar basement membrane. The detection of circulating anti-GBM antibodies, which are shown to be directly pathogenic, is central to disease diagnosis. Clinically, anti-GBM disease usually presents with rapidly progressive glomerulonephritis with or without alveolar hemorrhage. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.011DOI Listing
November 2018
3 Reads

Thrombotic Microangiopathies with Rheumatologic Involvement.

Rheum Dis Clin North Am 2018 11 7;44(4):635-649. Epub 2018 Sep 7.

Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, 2150 Pennsylvania Avenue, Washington, DC 20037, USA. Electronic address:

Thrombotic microangiopathies are heterogeneous disorders characterized by microangiopathic hemolytic anemia with thrombocytopenia and renal injury. There are a variety of causes, including metabolic disorders, infections, medications, complement disorders, pregnancy, malignancy, and autoimmune disorders. This review focuses on renal thrombotic microangiopathy in the setting of rheumatologic diseases. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.010DOI Listing
November 2018
31 Reads

Acute and Chronic Tubulointerstitial Nephritis of Rheumatic Causes.

Rheum Dis Clin North Am 2018 11 7;44(4):619-633. Epub 2018 Sep 7.

Department of Medicine, Division of Nephrology, Hospital Costa del Sol, A-7, Km 187, 29305 Marbella, Malaga, Spain.

Tubulointerstitial nephritis (TIN) is the second most common cause of acute intrinsic kidney injury after acute tubular necrosis. Although drug-induced forms of TIN represent the vast majority, rheumatic disease is another common cause and often underdiagnosed. Early diagnosis of acute interstitial nephritis and prompt withdrawal of the culprit medication or a correct treatment can avoid chronic damage and progressive chronic kidney disease. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.009DOI Listing
November 2018
20 Reads

Nephrotoxicity of Select Rheumatologic Drugs.

Rheum Dis Clin North Am 2018 11 7;44(4):605-617. Epub 2018 Sep 7.

Division of Nephrology and Hypertension, Department of Medicine, Oregon Health & Science University, Oregon Health & Science University, 3181 Southwest Sam Jackson Road, Portland, OR 97239, USA. Electronic address:

Several drugs commonly used in the management of rheumatic diseases may lead to nephrotoxicity, electrolyte disturbances, and hypertension. Here the authors focus on nonsteroidal antiinflammatory drugs, uric-acid-lowering therapy, and commonly used immunosuppressant therapies. The authors include a drug dosing table for patients with kidney disease. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.005DOI Listing
November 2018
9 Reads

Secondary, AA, Amyloidosis.

Rheum Dis Clin North Am 2018 11 7;44(4):585-603. Epub 2018 Sep 7.

National Amyloidosis Centre, Royal Free Campus, University College Medical School, Rowland Hill Street, London NW3 2PF, UK.

Secondary, AA, amyloidosis is a rare systemic complication that can develop in any long-term inflammatory disorder, and is characterized by the extracellular deposition of fibrils derived from serum amyloid A (SAA) protein. SAA is an acute-phase reactant synthetized largely by hepatocytes under the transcriptional regulation of proinflammatory cytokines. The kidney is the major involved organ with proteinuria as first clinical manifestation; renal biopsy is the commonest diagnostic investigation. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.004DOI Listing
November 2018
4 Reads

Renal Manifestations of Rheumatoid Arthritis.

Rheum Dis Clin North Am 2018 11 7;44(4):571-584. Epub 2018 Sep 7.

Department of Medicine, Division of Rheumatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.

Renal manifestations in rheumatoid arthritis (RA) have evolved as RA management has improved. In the past, older disease-modifying antirheumatic drugs, uncontrolled systemic inflammation, and chronic nonsteroidal antiinflammatory drug (NSAID) use contributed to kidney disease. Over time, the use of methotrexate and biologic medications, decrease in NSAID use, and a treat-to-target strategy have contributed to a decrease in renal manifestations. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.008DOI Listing
November 2018
3 Reads

Nonproliferative Forms of Lupus Nephritis: An Overview.

Authors:
Andrew S Bomback

Rheum Dis Clin North Am 2018 11 7;44(4):561-569. Epub 2018 Sep 7.

Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH 4-124, New York, NY 10032, USA. Electronic address:

Most of the attention paid to lupus nephritis, in the medical literature and in clinical trials, has primarily focused on proliferative forms of lupus nephritis (class III and IV lesions), but with lower thresholds to biopsy and rebiopsy patients with lupus, clinicians are encountering more cases with purely mesangial disease (class I and II) or membranous nephropathy patterns (class V). These lesions often will be associated with milder disease courses but still require dedicated follow-up by a nephrologist and focused therapeutic strategies that, at times, will include immunosuppression. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.003DOI Listing
November 2018
2 Reads

Therapy for Proliferative Lupus Nephritis.

Rheum Dis Clin North Am 2018 11 7;44(4):545-560. Epub 2018 Sep 7.

Division of Nephrology, Icahn School of Medicine at Mount Sinai, Box 1243, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address:

Proliferative lupus nephritis requires prompt diagnosis and treatment with immunosuppressive therapy. Cyclophosphamide is the longest studied agent, but mycophenolate mofetil has recently emerged as an efficacious induction and maintenance treatment that does not impart the risk of infertility. However, overall remission rates remain suboptimal and there is a need for improved therapeutic options. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.002DOI Listing
November 2018
2 Reads

Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Rheum Dis Clin North Am 2018 11 7;44(4):525-543. Epub 2018 Sep 7.

Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, 101 Merrimac Street, Boston, MA 02114, USA. Electronic address:

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is the most common cause of rapidly progressive glomerulonephritis. ANCAs play an important role in the pathogenesis and diagnosis of AAV. The classic renal lesion in AAV is a pauci-immune necrotizing and crescentic glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.001DOI Listing
November 2018
13 Reads

Rheumatic Diseases in Older Adults.

Rheum Dis Clin North Am 2018 Aug;44(3):xiii-xiv

National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 2-1341, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087544PMC
August 2018
1 Read
2.692 Impact Factor

Rheumatic Diseases in Older Adults.

Rheum Dis Clin North Am 2018 Aug;44(3):xi-xii

Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, 1545 Calmar Court, Los Angeles, CA 90024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2018.05.002DOI Listing
August 2018
2 Reads

Nonsurgical Management of Osteoarthritis Knee Pain in the Older Adult: An Update.

Authors:
Nora Taylor

Rheum Dis Clin North Am 2018 Aug 12;44(3):513-524. Epub 2018 Jun 12.

Division of Rheumatology, Mid-Atlantic Permanente Medical Group, 6501 Loisdale Court, Springfield, VA 22150, USA. Electronic address:

Symptomatic knee osteoarthritis is a common complaint of many elderly patients in primary care offices. For those unable or unwilling to undergo knee replacement, the primary practitioners' understanding of the strengths and weaknesses of the available treatment modalities for pain relief is critical to successful in-office counseling and expectation management. Treatment requires a multimodal approach of nonpharmacologic and pharmacologic therapies to achieve a maximal clinical benefit. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.009DOI Listing
August 2018
8 Reads

Lumbar Spinal Stenosis in Older Adults.

Rheum Dis Clin North Am 2018 Aug 12;44(3):501-512. Epub 2018 Jun 12.

Department of Medicine, Loma Linda University, Loma Linda University Medical Center, 11234 Anderson Street, MC 1519, Loma Linda, CA 92354, USA. Electronic address:

Lumbar spinal stenosis (LSS) is a frequent cause of low back pain among adults, caused by a narrowing impinging on the spinal cord or nerve roots. Several conditions cause LSS, including disc herniation, spondylolisthesis, tumor, fractures, and other degenerative changes. Back pain is frequently experienced. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.008DOI Listing
August 2018
22 Reads

Crystal-Induced Arthritides in the Elderly: An Update.

Rheum Dis Clin North Am 2018 Aug 12;44(3):489-499. Epub 2018 Jun 12.

Department of Rheumatic and Immunologic Disease, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue, A50, Cleveland, OH 44195, USA.

The prevalence of gout increases with age. After the serum concentration of urate exceeds the saturation or solubility point, it deposits in and around the joints. Presentation in the elderly is often atypical and challenging to diagnose. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.007DOI Listing
August 2018
2 Reads

Update on Cardiovascular Disease Risk in Patients with Rheumatic Diseases.

Rheum Dis Clin North Am 2018 Aug 12;44(3):475-487. Epub 2018 Jun 12.

Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Thomas E. Starzl Biomedical Science Tower South 711, Pittsburgh, PA 15261, USA.

Cardiovascular disease (CVD) risk is 1.5-fold higher in rheumatoid arthritis (RA), partly due to subclinical atherosclerosis that develops before the diagnosis of RA. Dyslipidemia in RA is better quantified by lipoproteins and apolipoproteins than by cholesterol levels. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.006DOI Listing
August 2018
5 Reads

Regional Rheumatic Disorders and Rehabilitation in Older Adults: An Update.

Rheum Dis Clin North Am 2018 Aug;44(3):453-473

Rehabilitation Medicine Department, National Institutes of Health Clinical Center, 10 Center Drive, Building 10, CRC, Room 1-1469, Bethesda, MD 20892-1604, USA.

Musculoskeletal problems are the most frequently reported complaints among older adults living in the community. The impact of the aging process on skeletal muscles and joints can have a profound effect on the ability of individuals to function. This article reviews the rehabilitation medicine approach to the evaluation of older adults with regional rheumatic disorders and the rehabilitation medicine considerations for clinical intervention. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.005DOI Listing
August 2018
12 Reads

A Review of Osteoporosis in the Older Adult: An Update.

Rheum Dis Clin North Am 2018 Aug 13;44(3):437-451. Epub 2018 Jun 13.

Division of Rheumatology, MedStar Washington Hospital Center, Georgetown University Medical Center, 110 Irving Street Northwest 2A-66, Washington, DC 20010, USA.

Osteoporosis in the elderly population is common. It results in more than 1.5 million fractures per year in the United States. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.004DOI Listing
August 2018
17 Reads

Update on Sjögren Syndrome and Other Causes of Sicca in Older Adults.

Rheum Dis Clin North Am 2018 08;44(3):419-436

National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

Dry eye and dry mouth symptoms are each reported by up to 30% of persons more than 65 years of age, particularly in women. Medication side effects are the most common contributing factors. The evaluation of these symptoms requires measures of ocular and oral dryness. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245643PMC
August 2018
6 Reads

The Relationship Between Rheumatologic Disorders and Malignancies.

Authors:
Mandana Hashefi

Rheum Dis Clin North Am 2018 08 13;44(3):405-418. Epub 2018 Jun 13.

Division of Rheumatology, George Washington University, 2300, M Street, Northwest, Suite: 3-307, Washington, DC 20037, USA. Electronic address:

A variety of conditions mimicking rheumatologic syndromes may be associated with an underlying malignancy. Therefore, distinguishing these syndromes from more common, nonparaneoplastic rheumatologic conditions can be perplexing. Some autoimmune conditions and the medications used for their management can be associated with increased future risk of malignancy. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.003DOI Listing
August 2018
5 Reads

Sarcopenia: A Rheumatic Disease?

Rheum Dis Clin North Am 2018 08 12;44(3):393-404. Epub 2018 Jun 12.

Lupus Clinical Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room Number 3-2340, Bethesda, MD 20892, USA. Electronic address:

Sarcopenia refers to the age-related loss of muscle mass, muscle strength, and physical function. With an increase in the number and proportion of elderly in the population, sarcopenia is a growing global health concern due to its impact on morbidity, mortality, and health care expenditure. Despite its clinical importance, sarcopenia remains underrecognized and poorly managed in routine clinical practice. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047534PMC
August 2018
24 Reads

Pharmacotherapy Pearls in Rheumatology for the Care of Older Adult Patients: Focus on Oral Disease-Modifying Antirheumatic Drugs and the Newest Small Molecule Inhibitors.

Rheum Dis Clin North Am 2018 08 12;44(3):371-391. Epub 2018 Jun 12.

National Institutes of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health Clinical Center, Bethesda, MD 20814, Maryland, USA.

Providing safe and effective pharmacotherapy to geriatric patients with rheumatologic disorders is challenging. Multidisciplinary care involving rheumatologists, primary care physicians, and other specialties can optimize benefit and reduce adverse outcomes. Oral disease-modifying antirheumatic drugs, including methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide, and the small molecule inhibitors tofacitinib and apremilast have distinctive monitoring requirements and specific adverse reaction profiles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0889857X183003
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http://dx.doi.org/10.1016/j.rdc.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047536PMC
August 2018
5 Reads
2.692 Impact Factor

Advanced Epidemiologic Methods for the Study of Rheumatic and Musculoskeletal Diseases.

Authors:
Sindhu R Johnson

Rheum Dis Clin North Am 2018 May;44(2):xv-xvi

Division of Rheumatology, Department of Medicine, Toronto Western Hospital, Ground Floor, East Wing, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada; Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario M5S 1K7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2018.02.001DOI Listing
May 2018
2 Reads

The Brave New World of Rheumatic Disease Research Today.

Rheum Dis Clin North Am 2018 May;44(2):xiii

Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, 1545 Calmar Court, Los Angeles, CA 90024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rdc.2018.02.002DOI Listing
May 2018
2 Reads

Applied Bayesian Methods in the Rheumatic Diseases.

Rheum Dis Clin North Am 2018 05;44(2):361-370

Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Division of Rheumatology, Department of Paediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

The use of applied Bayesian methods is increasing in rheumatology. Using the Bayes theorem, past evidence is updated with new data. Preexisting data are expressed as a prior probability distribution or prior. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.003DOI Listing
May 2018
4 Reads

Cluster and Multiple Correspondence Analyses in Rheumatology: Paths to Uncovering Relationships in a Sea of Data.

Rheum Dis Clin North Am 2018 05;44(2):349-360.e29

Department of Medical Imaging, University of Toronto, 263 McCaul Street, Toronto, Ontario M5T 1W7, Canada; Department of Statistical Sciences, University of Toronto, 100 St George Street, Toronto, Ontario M5S 3G3, Canada. Electronic address:

Rheumatic diseases encompass a wide range of conditions caused by inflammation and dysregulation of the immune system resulting in organ damage. Research in these heterogeneous diseases benefits from multivariate methods. The aim of this review was to describe and evaluate current literature in rheumatology regarding cluster analysis and correspondence analysis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.013DOI Listing
May 2018
3 Reads

Measuring Patient Preferences: An Overview of Methods with a Focus on Discrete Choice Experiments.

Authors:
Glen S Hazlewood

Rheum Dis Clin North Am 2018 05 21;44(2):337-347. Epub 2018 Feb 21.

Department of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N4Z6, Canada; Department of Community Health Sciences, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N4Z6, Canada. Electronic address:

There is increasing recognition of the importance of patient preferences and methodologies to measure them. In this article, methods to quantify patient preferences are reviewed, with a focus on discrete choice experiments. In a discrete choice experiment, patients are asked to choose between 2 or more treatments. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.009DOI Listing
May 2018
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Use of Administrative Databases to Assess Reproductive Health Issues in Rheumatic Diseases.

Rheum Dis Clin North Am 2018 05 10;44(2):327-336. Epub 2018 Feb 10.

Medicine, Duke University School of Medicine, Box 3535 Trent Drive, Durham, NC 27710, USA.

Administrative databases, registers, and other sources of big data can be interesting sources to address important research questions on reproduction in women with rheumatic diseases. There are many different types of administrative datasets worldwide, and it is important to understand the type of data present and unavailable in each dataset, validity and potential misclassification of data, and the ability to link maternal data with infant data. This article discusses the advantages and methodologic issues associated with administrative database use for the conduct of observational studies on reproductive issues in women with rheumatic diseases. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.008DOI Listing
May 2018
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Strategies for Dealing with Missing Accelerometer Data.

Rheum Dis Clin North Am 2018 May 21;44(2):317-326. Epub 2018 Feb 21.

Child Health Evaluative Sciences, The Hospital for Sick Children, Department of Pediatrics, Institute of Health Policy Management and Evaluation, The Dalla Lana School of Public Health, The University of Toronto, Toronto, Ontario, Canada.

Missing data is a universal research problem that can affect studies examining the relationship between physical activity measured with accelerometers and health outcomes. Statistical techniques are available to deal with missing data; however, available techniques have not been synthesized. A scoping review was conducted to summarize the advantages and disadvantages of identified methods of dealing with missing data from accelerometers. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.012DOI Listing
May 2018
2 Reads
2.690 Impact Factor

"Big Data" in Rheumatology: Intelligent Data Modeling Improves the Quality of Imaging Data.

Rheum Dis Clin North Am 2018 May;44(2):307-315

Leiden University Medical Center, Leiden, the Netherlands.

Analysis of imaging data in rheumatology is a challenge. Reliability of scores is an issue for several reasons. Signal-to-noise ratio of most imaging techniques is rather unfavorable (too little signal in relation to too much noise). Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.007DOI Listing
May 2018
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Randomized Trials, Meta-Analyses, and Systematic Reviews: Using Examples from Rheumatology.

Rheum Dis Clin North Am 2018 05;44(2):295-305

Department of Medicine, University of Calgary, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada; Department of Community Health Sciences, University of Calgary, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada.

This article introduces contemporary ideas and standards for clinical research in rheumatology for randomized trials, systematic reviews, and meta-analyses. Examples of different randomized trials in rheumatic diseases are provided to understand the methods for trials and the rationale for outcomes within trials. Insights from meta-analyses and systematic literature reviews, including network meta-analyses within rheumatology treatment, are provided. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.006DOI Listing
May 2018
2 Reads

Similarity Network Fusion: A Novel Application to Making Clinical Diagnoses.

Rheum Dis Clin North Am 2018 May 21;44(2):285-293. Epub 2018 Feb 21.

Genetics and Genome Biology, Department of Computer Science, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning (PGCRL), University of Toronto, 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.

Similarity Network Fusion (SNF) is a novel methodological tool that integrates multiple different types of data to identify homogeneous subsets of patients in whom disease classification may be otherwise unclear or challenging. In this review article, the authors hope to provide insight into how SNF can be used in clinical decision making where the aim is to have little influence on the data prior to obtaining the results of the analysis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.005DOI Listing
May 2018
3 Reads

Qualitative Methods to Advance Care, Diagnosis, and Therapy in Rheumatic Diseases.

Rheum Dis Clin North Am 2018 May 21;44(2):267-284. Epub 2018 Feb 21.

Royal National Hospital for Rheumatic Diseases, Royal United Hospitals, Upper Borough Walls, Bath BA1 1RL, UK; Department of Pharmacy and Pharmacology, University of Bath, Bath BA11RL, UK.

This article provides an overview of the basis, usefulness, and validity of qualitative methods in research. It is aimed to enhance the understanding of a broad spectrum of readers, ranging from those mystified by such approaches, to those wanting a better critical knowledge to apply to literature review, and for health care providers considering developing an interest in the field. Qualitative research is crucial in augmentation of disease knowledge as well as the development of incremental care strategies and operational aspects of care that improves health outcomes. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890953PMC
May 2018
2 Reads