24,072 results match your criteria Rheumatic Fever


Takayasu arteritis in a patient diagnosed with acute rheumatic fever presenting with carditis: Is it a coincidental association or an aetiological relationship?

J Paediatr Child Health 2020 Jul 4. Epub 2020 Jul 4.

Faculty of Medicine, Department of Pediatric Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey.

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http://dx.doi.org/10.1111/jpc.14992DOI Listing

Acute rheumatic fever in south-east of Turkey: clinical features and epidemiological evaluation of the patients over the last 25 years.

Cardiol Young 2020 Jul 2:1-9. Epub 2020 Jul 2.

Department of Pediatric Cardiology, Faculty of Medicine, Çukurova University, Adana, Turkey.

This study evaluates clinical and epidemiological features of acute rheumatic fever using the data of last 25 years in our hospital in south-east of Turkey. The medical records of 377 patients with acute rheumatic fever admitted to Pediatric Cardiology Department of Çukurova University during 1993-2017 were retrospectively analysed. Two hundred and six patients were admitted between 1993 and 2000, 91 between 2001 and 2008, and 80 between 2009 and 2017. Read More

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http://dx.doi.org/10.1017/S1047951120001596DOI Listing

[Diagnosis and treatment of acute tonsillopharyngitis. Consensus document update].

An Pediatr (Barc) 2020 Jun 27. Epub 2020 Jun 27.

Sociedad Española de Pediatría Extrahospitalaria y Atención Primaria (SEPEAP).

An update of the Spanish consensus document on the diagnosis and treatment of acute tonsillopharyngitis is presented. Clinical scores should not be used to prescribe antibiotics, unless microbiological tests are not available or there is a child at risk of rheumatic fever. There is no score better than those set out in the previous consensus. Read More

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http://dx.doi.org/10.1016/j.anpedi.2020.05.004DOI Listing

Diagnosis of rheumatic fever: the need for a better test.

Arch Dis Child 2020 Jun 29. Epub 2020 Jun 29.

Tropical Diseases Research Group, Murdoch Children's Research Institute, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia

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http://dx.doi.org/10.1136/archdischild-2020-318970DOI Listing

Cross-sectional study of population-specific streptococcal antibody titres in Uganda.

Arch Dis Child 2020 Jun 29. Epub 2020 Jun 29.

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Objective: Despite substantial variation of streptococcal antibody titres among global populations, there is no data on normal values in sub-Saharan Africa. The objective of this study was to establish normal values for antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies in Uganda.

Design: This was an observational cross-sectional study. Read More

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http://dx.doi.org/10.1136/archdischild-2020-318859DOI Listing

Coronavirus disease 2019 (COVID-19) in a patient with ankylosing spondylitis treated with secukinumab: a case-based review.

Rheumatol Int 2020 Jun 26. Epub 2020 Jun 26.

Department of Physical Medicine and Rehabilitation, Cukurova University Faculty of Medicine, Adana, Turkey.

Severe acute respiratory syndrome coranovirus-2 (SARS-CoV-2) infection has become an important health-care issue worldwide. The coronavirus disease 2019 (COVID-19) has also raised concerns among patients with inflammatory rheumatic conditions and their treating physicians. There are emerging data regarding the potential risks of SARS-CoV-2 for this particular patient group. Read More

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http://dx.doi.org/10.1007/s00296-020-04635-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319213PMC

Severe COVID-19, Another Piece in the Puzzle of the Hyperferritinemic Syndrome. An Immunomodulatory Perspective to Alleviate the Storm.

Front Immunol 2020;11:1130. Epub 2020 May 28.

Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

The coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has been declared as a worldwide public health emergency. Interestingly, severe COVID-19 is characterized by fever, hyperferritinemia, and a hyper-inflammatory process with a massive release of pro-inflammatory cytokines, which may be responsible for the high rate of mortality. These findings may advocate for a similarity between severe COVID-19 and some challenging rheumatic diseases, such as adult onset Still's disease, secondary hemophagocytic lymphohistiocytosis, and catastrophic anti-phospholipid syndrome, which have been included in the "hyperferritinemic syndrome" category. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270352PMC

Sydenham chorea in a12- year old Saudi girl.

eNeurologicalSci 2020 Sep 6;20:100246. Epub 2020 Jun 6.

Radiology Department, Al- Azhar University, Egypt.

Sydenham chorea (SC) is the most common acquired cause of chorea in children. (SC) is the neurological manifestation of rheumatic fever. Rheumatic fever is still reported in Saudi Arabia, although less frequently. Read More

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http://dx.doi.org/10.1016/j.ensci.2020.100246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296341PMC
September 2020

New guidelines for diagnosis of rheumatic fever; do they apply to all populations?

Turk J Pediatr 2020 ;62(3):411-423

Department of Critical Care, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Objectives: To evaluate the efficacy of recently updated Jones criteria for diagnosis of rheumatic fever in high incidence populations like Egypt.

Methods: Clinical data of 891 Egyptian patients with rheumatic fever, aged 5-15 years in a highly specialized rheumatic fever clinic were reviewed retrospectively from March 2014 to March 2016. Discriminant analysis was used to detect the most effective predictors for diagnosis of rheumatic fever in our patients incorporating echocardiographic criteria. Read More

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http://dx.doi.org/10.24953/turkjped.2020.03.008DOI Listing
January 2020

A Case of Cytomegalovirus-Induced Hemophagocytic Lymphohistiocytosis in a Patient with an Underlying Rheumatic Disease.

Cureus 2020 May 15;12(5):e8130. Epub 2020 May 15.

Rheumatology, Temple University Hospital, Philadelphia, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition caused by overproduction of inflammatory cytokines and overactivation of macrophages that can progress to multiorgan dysfunction and failure. Although there are guidelines that attempt to recognize the condition in its early stage, diagnosis can be very challenging due to heterogeneous presentations of HLH. Symptoms and clinical findings include fever, neurologic complaints, respiratory issues, liver dysfunction, cytopenias, amongst others most of which are not specific to HLH. Read More

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http://dx.doi.org/10.7759/cureus.8130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294891PMC

Macrophage activation syndrome as a complication of dermatomyositis: A case report.

World J Clin Cases 2020 Jun;8(11):2339-2344

Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Background: Macrophage activation syndrome (MAS) can be a fatal complication of rheumatic disorders, which occurs most commonly in patients with systemic juvenile idiopathic arthritis or systemic lupus erythematosus. It has rarely been reported in patients with dermatomyositis. Here, we describe a fatal case of MAS that developed in an adult patient with dermatomyositis. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281037PMC

Complicated skin and soft tissue infections in remote indigenous communities.

Intern Med J 2020 Jun;50(6):752-754

Menzies School of Health Research, Darwin, Northern Territory, Australia.

The burden and consequences of skin infections for remote living indigenous people are high. While skin infections are recognised as an antecedent to conditions such as acute rheumatic fever in children, data are limited concerning skin infection complications such as cellulitis, abscesses and osteomyelitis in older children and adults. In a 1-year retrospective audit of 439 patients presenting to two remote health clinics, 330/439 (75%) patients presented with a skin infection and 18 (4%) developed a complication. Read More

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http://dx.doi.org/10.1111/imj.14858DOI Listing

SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy: A cross-sectional study on 916 patients.

J Autoimmun 2020 Jun 8:102502. Epub 2020 Jun 8.

Division of Rheumatology, Department of Medicine DIMED, University of Padua, Italy. Electronic address:

Background: Whether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy.

Methods: Between April 9th and April 25th 2020, after SARS-CoV-2 infection peak, a telephone survey investigating the impact of COVID-19 on patients with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), ANCA-associated vasculitis (AAV), and idiopathic inflammatory myopathies (IIM) was administered. Read More

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http://dx.doi.org/10.1016/j.jaut.2020.102502DOI Listing

Characteristics of Children with Acute Rheumatic Carditis from a High-Incidence Region: Importance of Unexplained Worsening of Functional Class.

Cardiology 2020 Jun 11:1-7. Epub 2020 Jun 11.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

Background: Acute rheumatic fever (ARF) and acute rheumatic carditis (ARC) continue to be a major public health problem in developing countries.

Objective: To study the characteristics of children with ARC being treated at a tertiary centre.

Methods And Results: We studied 126 children (mean age 10. Read More

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http://dx.doi.org/10.1159/000508035DOI Listing
June 2020
2.044 Impact Factor

Rheumatic fever recurrences in New Zealand 2010-14.

N Z Med J 2020 Jun 12;133(1516):47-57. Epub 2020 Jun 12.

Consultant Paediatric Cardiologist, Green Lane Paediatric & Congenital Cardiac Services, Starship Children's Hospital and Honorary Clinical Associate Professor, University of Auckland, Auckland.

Aim: To describe the epidemiology and clinical characteristics of recurrences of acute rheumatic fever (ARF) in New Zealand 2010-14.

Method: Retrospective hospital chart review for ARF with repeat hospital admissions from 2010-14, to identify recurrences of ARF. Definitions of recurrence as per NZ Heart Foundation Guidelines. Read More

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Screening for rheumatic heart disease: The reliability of anterior mitral valve leaflet thickness measurement.

Echocardiography 2020 Jun 10;37(6):808-814. Epub 2020 Jun 10.

Faculty of Medicine and Health Sciences, Department of Medicine, Division of Cardiology, Tygerberg Academic Hospital and University of Stellenbosch, Cape Town, South Africa.

Background: Studies determining the reliability of the World Heart Federation (WHF) anterior mitral valve leaflet (AMVL) measurement are limited by the introduction of bias in their test-retest analyses. This study sought to determine the reliability of the current AMVL measurement while controlling for systematic bias.

Methods: Retrospective analysis of echocardiographic data from 16 patients with previous acute rheumatic fever was performed. Read More

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http://dx.doi.org/10.1111/echo.14751DOI Listing

School-Based Streptococcal A Sore-Throat Treatment Programs and Acute Rheumatic Fever Amongst Indigenous Māori: A Retrospective Cohort Study.

Pediatr Infect Dis J 2020 Jun 3. Epub 2020 Jun 3.

From the Pediatric Department, University of Auckland, Auckland, New Zealand.

Background: Acute rheumatic fever (ARF) predominantly affects indigenous Māori schoolchildren in Bay of Plenty region, and more so male Māori students, especially when socioeconomically deprived. We evaluated the effectiveness of strategies for reducing ARF with group A streptococcal pharyngitis treatment in 2011-18.

Methods: We retrospectively assessed outcomes of 3 open cohorts of Māori schoolchildren receiving different interventions: Eastern Bay rural Cohort 1, mean deprivation decile 9. Read More

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http://dx.doi.org/10.1097/INF.0000000000002770DOI Listing

Implications of COVID-19 in pediatric rheumatology.

Rheumatol Int 2020 Aug 4;40(8):1193-1213. Epub 2020 Jun 4.

Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey.

COVID-19 (coronavirus disease 2019) pandemic caused by SARS-CoV-2, is a global public health issue threatening millions of lives worldwide. Although the infection is mild in most of the affected individuals, it may cause severe clinical manifestations such as acute respiratory distress syndrome or cytokine storm leading to death. Children are affected less, and most experience a milder disease. Read More

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http://dx.doi.org/10.1007/s00296-020-04612-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270517PMC

Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children.

Ann Intensive Care 2020 Jun 1;10(1):69. Epub 2020 Jun 1.

Pediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris University, EA7323, 75006, Paris, France.

Background: A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020.

Results: 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25-55); troponin, 269 ng/mL (31-4607)), and arterial hypotension with mainly vasoplegic clinical presentation. Read More

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http://dx.doi.org/10.1186/s13613-020-00690-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266128PMC

Clinical and Genetic Analysis of 22 Japanese Patients with Familial Mediterranean Fever: An Examination of MEFV and 10 Other Genes Related to Autoinflammatory Syndromes.

Intern Med 2020 1;59(11):1373-1378. Epub 2020 Jun 1.

Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.

Objective Familial Mediterranean Fever (FMF) is the most frequent autoinflammatory syndrome, and its frequency is reported to be increasing in Japan. We studied the clinical features and genetic background of patients with FMF in our hospital. Methods We analyzed the clinical features and genomic variants of MEFV, as well as 10 genes related to other autoinflammatory syndromes, in 22 Japanese patients with FMF. Read More

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http://dx.doi.org/10.2169/internalmedicine.3778-19DOI Listing

Rheumatoid Meningitis a Rare Extra-Articular Manifestation of Rheumatoid Arthritis: Report of 6 Cases and Literature Review.

J Clin Med 2020 May 27;9(6). Epub 2020 May 27.

Rheumatology department, CHU Grenoble Alpes, Hôpital Sud, 38130 Echirolles, France.

Objectives: Central neurological manifestations of rheumatoid arthritis (RA) like rheumatoid meningitis (RM) are rare, little known and have a high rate of morbi-mortality.

Methods: We described six cases of RM that were directly related to RA activity after exhaustive assessment.

Results: They were mainly women, aged of 50 to 69. Read More

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http://dx.doi.org/10.3390/jcm9061625DOI Listing

Development and evaluation of a new triplex immunoassay that detects Group A antibodies for the diagnosis of rheumatic fever.

J Clin Microbiol 2020 May 27. Epub 2020 May 27.

School of Medical Sciences, The University of Auckland, New Zealand

Streptococcal serology is a cornerstone in the diagnosis of acute rheumatic fever (ARF), a post-infectious sequalae associated with Group A infection. Current tests that measure anti-streptolysin-O (ASO) and anti-DNaseB (ADB) titres require parallel processing, with predictive value limited by the slow rate of decay in antibody response. Accordingly, our objective was to develop and assess the diagnostic potential of a triplex bead-based assay, which simultaneously quantifies ASO and ADB together with titres for a third antigen, SpnA. Read More

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http://dx.doi.org/10.1128/JCM.00300-20DOI Listing
May 2020
3.993 Impact Factor

Clinical features of rheumatic patients infected with COVID-19 in Wuhan, China.

Ann Rheum Dis 2020 May 22. Epub 2020 May 22.

Department of Rheumatology and Immunology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China

Objective: The clinical features of rheumatic patients with coronavirus disease 2019 (COVID-19) have not been reported. This study aimed to describe the clinical features of COVID-19 in rheumatic patients and provide information for handling this situation in clinical practice.

Methods: This is a retrospective case series study. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295865PMC

Distribution of Streptococcal Pharyngitis and Acute Rheumatic Fever, Auckland, New Zealand, 2010-2016.

Emerg Infect Dis 2020 Jun;26(6):1113-1121

Group A Streptococcus (GAS) pharyngitis is a key initiator of acute rheumatic fever (ARF). In New Zealand, ARF cases occur more frequently among persons of certain ethnic and socioeconomic groups. We compared GAS pharyngitis estimates (1,257,058 throat swab samples) with ARF incidence (792 hospitalizations) in Auckland during 2010-2016. Read More

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http://dx.doi.org/10.3201/eid2606.181462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258449PMC

Rheumatic heart disease: current status of diagnosis and therapy.

Cardiovasc Diagn Ther 2020 Apr;10(2):305-315

Division of Paediatric Cardiology, Department of Paediatrics, Red Cross Children's Hospital, University of Cape Town, Cape Town, South Africa.

Rheumatic heart disease (RHD) is the only preventable cardiovascular disease which causes significant morbidity and mortality particularly in low- and middle-income countries. Early clinical diagnosis is key, the updated Jones criteria increases the likelihood of diagnosis in endemic settings, including the echo diagnosis of sub-clinical carditis, polyarthralgia and monoarthritis as well as amended thresholds of minor criteria. The mainstay of rheumatic heart valve disease (RHVD) is a thorough clinical and echocardiographic investigation while severe disease is managed with medical, interventional and surgical treatment. Read More

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http://dx.doi.org/10.21037/cdt.2019.10.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225445PMC

Sacroiliitis associated with familial Mediterranean fever in childhood: a case series and review of literature.

Turk J Pediatr 2020 ;62(2):175-181

Divisions of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey.

Background And Objectives: Familial Mediterranean fever (FMF) is an autosomal-recessive auto-inflammatory disorder characterized by recurrent episodes of fever with serositis. Sacroiliitis associated with FMF is very rare, especially in children. We aimed to describe the demographic, clinical, laboratory features, and treatment responses of pediatric patients with FMF -related sacroiliitis. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.002DOI Listing
January 2020

Canakinumab in colchicine resistant familial Mediterranean fever and other pediatric rheumatic diseases.

Turk J Pediatr 2020 ;62(2):167-174

Clinic of Pediatric Rheumatology, Kanuni Sultan Süleyman Research and Training Hospital, İstanbul, Turkey.

Background And Objectives: The aim of this observational retrospective cohort study was to demonstrate indications and response rates of the patients with pediatric rheumatic diseases that used canakinumab.

Method: The files of the patients that used canakinumab between December 2012 and July 2017 were reviewed. Canakinumab was used in 29 patients. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.001DOI Listing
January 2020

Non-steroidal anti-inflammatory drugs, pharmacology, and COVID-19 infection.

Therapie 2020 May 7. Epub 2020 May 7.

Centre hospitalier régional universitaire de Tours, service de pharmacosurveillance, centre régional de pharmacovigilance, 37000 Tours, France.

Non-steroidal anti-inflammatory drugs (NSAIDs) have an optional prescription status that has resulted in frequent use, in particular for the symptomatic treatment of fever and non-rheumatic pain. In 2019, a multi-source analysis of complementary pharmacological data showed that using NSAIDs in these indications (potentially indicative of an underlying infection) increases the risk of a severe bacterial complication, in particular in the case of lung infections. First, the clinical observations of the French Pharmacovigilance Network showed that severe bacterial infections can occur even after a short NSAID treatment, and even if the NSAID is associated with an antibiotic. Read More

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http://dx.doi.org/10.1016/j.therap.2020.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204680PMC

Linezolid Induced Skin Reactions In A Multi Drug Resistant Infective Endocarditis Patient: A Rare Case.

Curr Drug Saf 2020 May 16. Epub 2020 May 16.

Department of Pharmacy Practice, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Nagamangala 571448, Karnataka. India.

Rationale: Linezolid (LNZ) induced Cutaneous Adverse Drug Reactions (CADRs) are rare atypical presentation. Till date, there are very few published case reports on the LNZ induced CADRs among the multidrug resistant patients suffering from Infective Endocarditis (MDR IE). Here, we present a rare case report of LNZ induced CARs in a MDR IE patient. Read More

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http://dx.doi.org/10.2174/1574886315666200516175053DOI Listing

COVID-19 with rheumatic diseases: a report of 5 cases.

Clin Rheumatol 2020 Jul 14;39(7):2025-2029. Epub 2020 May 14.

Department of Rehabilitation Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, 432100, Hubei, China.

The coronavirus disease 2019 (COVID-19), the result of an infection with the new virus, SARS-CoV-2, is rapidly spreading worldwide. It is largely unknown whether the occurrence of COVID-19 in patients with rheumatic immune diseases has some specific manifestations, or makes them more prone to rapidly progress into severe COVID-19. In this case report, we describe the clinical features of 5 rheumatic immune disease patients with the concomitant presence of COVID-19. Read More

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http://dx.doi.org/10.1007/s10067-020-05160-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220846PMC

Pediatric Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) Syndrome: Diagnostic Challenges and Treatment Approach.

Cureus 2020 Apr 9;12(4):e7595. Epub 2020 Apr 9.

Orthopaedics, Panagiotis & Aglaia Kyriakou Children's Hospital, Athens, GRC.

Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare disease; however, more and more case reports have been published that increase the awareness of this disorder, especially in children. Clinically it presents as a combination of chronic recurrent multifocal osteomyelitis symptoms and skin manifestations. SAPHO treatment remains a challenge. Read More

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http://dx.doi.org/10.7759/cureus.7595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213676PMC

Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity.

Int J Mol Sci 2020 May 8;21(9). Epub 2020 May 8.

Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, 00182 Rome, Italy.

On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency. Typical manifestations consist of flu-like symptoms such as fever, cough, fatigue, and dyspnea. However, in about 20% of patients, the infection progresses to severe interstitial pneumonia and can induce an uncontrolled host-immune response, leading to a life-threatening condition called cytokine release syndrome (CRS). Read More

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http://dx.doi.org/10.3390/ijms21093330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247555PMC

The Prevalence of Periodontal Pathogenic Bacteria in Atherosclerotic Cardiovascular Disease.

Clin Lab 2020 May;66(5)

Background: A possible link between periodontal pathogenic bacteria and atherosclerosis may exist based on the inflammatory mechanisms initiated by bacteria found in periodontal lesions. Our aim was to investigate the presence of DNA originating from T. denticola, C. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2020.191146DOI Listing

Hemophagocytic lymphohistiocytosis: An update on pathogenesis, diagnosis, and therapy.

Best Pract Res Clin Rheumatol 2020 May 7:101515. Epub 2020 May 7.

Division of Rheumatology, University of Washington, Seattle, WA, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or neoplastic triggers. Sustained, aberrant activation of cytotoxic CD8 T cells and resultant inflammatory cytokine release are core pathogenic mechanisms. Key clinical features include high persistent fever, hepatosplenomegaly, blood cytopenia, elevated aminotransferase and ferritin levels, and coagulopathy. Read More

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http://dx.doi.org/10.1016/j.berh.2020.101515DOI Listing

Antimicrobial Stewardship: A Potentially Important Benefit of a Group A Streptococcus Vaccine in Areas with Low Rates of Acute Rheumatic Fever.

Clin Infect Dis 2020 May 6. Epub 2020 May 6.

Pediatrics, Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital, Chicago, IL.

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http://dx.doi.org/10.1093/cid/ciaa533DOI Listing

Are there any novel markers in acute rheumatic fever: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio.

Cardiol Young 2020 May 4;30(5):717-721. Epub 2020 May 4.

Mersin University, Department of Pediatric Cardiology, Mersin, Turkey.

Objective: The aim of this study was to investigate the relationship between C-reactive protein and erythrocyte sedimentation rate and neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios in acute rheumatic fever in children.

Method: In this retrospective study, 182 patients with acute rheumatic fever and 173 controls were included. Complete blood count parameters, and neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios were recorded for all the patients underwent transthoracic echocardiography. Read More

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http://dx.doi.org/10.1017/S104795112000089XDOI Listing

Type I Interferon in Children with Viral or Bacterial Infections.

Clin Chem 2020 Jun;66(6):802-808

Pediatric Emergency Unit, Hôpital Femme Mère Enfants, Hospices Civils of Lyon, Lyon, France.

Background: Fever is one of the leading causes of consultation in the pediatric emergency department for patients under the age of 3 years. Distinguishing between bacterial and viral infections etiologies in febrile patients remains challenging. We hypothesized that specific host biomarkers for viral infections, such as type I-interferon (IFN), could help clinicians' decisions and limit antibiotic overuse. Read More

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http://dx.doi.org/10.1093/clinchem/hvaa089DOI Listing

Macrophage activation syndrome in adult dermatomyositis: a case-based review.

Rheumatol Int 2020 Jul 30;40(7):1151-1162. Epub 2020 Apr 30.

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Macrophage activation syndrome (MAS) is a severe and life-threatening syndrome associated with autoimmune diseases, characterized by fever, hepatosplenomegaly, and pancytopenia. Dermatomyositis (DM) is one of the causes of MAS; however, its clinical characteristics in DM patients remain unclear. This study aimed to present a case of anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM complicated by MAS in a 29-year-old woman and to review the literatures including similar cases. Read More

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http://dx.doi.org/10.1007/s00296-020-04590-9DOI Listing

Surprising diagnosis in a patient with acute coronary syndrome: a case report of acute streptococcal pharyngitis-associated perimyocarditis.

Eur Heart J Case Rep 2020 Apr 17;4(2):1-6. Epub 2020 Feb 17.

Division of Cardiovascular Imaging, Department of Cardiology I, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149 Münster, Germany.

Background: Streptococcal pharyngitis is a common infection, with both suppurative and non-suppurative complications. Most importantly, a streptococcal infection can cause heart disease in different pathophysiological pathways. Acute non-rheumatic perimyocarditis appears to be a more frequent pathological entity associated with streptococcal pharyngitis as once thought, which is poorly understood and explored. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180564PMC

Classic and Non-classic (Surrepticius) Scabies: Diagnostic and Treatment Considerations.

Authors:
Philip R Cohen

Cureus 2020 Mar 25;12(3):e7419. Epub 2020 Mar 25.

Dermatology, San Diego Family Dermatology, National City, USA.

The morphology of scabies, a mite infestation of worldwide proportion, is characterized by a variety of cutaneous lesions. Patients with classic scabies present with characteristic burrows often located on the web spaces of the fingers and toes. Scabies surrepticius refers to the non-classic atypical presentation of scabies; establishing the diagnosis of scabies in these individuals can be difficult. Read More

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http://dx.doi.org/10.7759/cureus.7419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186094PMC

Screening Rheumatic Heart Disease in 1530 New Caledonian Adolescents.

J Am Heart Assoc 2020 May 26;9(9):e015017. Epub 2020 Apr 26.

Department of Cardiology Faculty of Medicine Jacques Lisfranc University Lyon-Saint-Etienne Saint-Etienne France.

BACKGROUND In New Caledonia, a South Pacific archipelago whose inhabitants comprise Melanesians, Europeans/whites, Wallisians, Futunans, Polynesians, and Asians, the prevalence of rheumatic heart disease (RHD) is 0.9% to 1% at ages 9 and 10. It could be higher at the age of 16, but this remains to be verified. Read More

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http://dx.doi.org/10.1161/JAHA.119.015017DOI Listing

Methylphenidate-induced Exacerbation of Chorea in a Child Resolved with Switching to Atomoxetine.

Clin Psychopharmacol Neurosci 2020 May;18(2):327-330

Department of Child and Adolescent Psychiatry, Medical Faculty, University of Health Sciences, Istanbul, Turkey.

Choreiform movements have been reported with stimulant medications, especially in adults. There is only limited evidence on the management of such reactions in children with attention deficit hyperactivity disorder. Hereby, we present the exacerbation of chorea with long-acting methylphenidate use in a 6-year-old child with acute rheumatic fever which resolved with switching to atomoxetine. Read More

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http://dx.doi.org/10.9758/cpn.2020.18.2.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242108PMC

Features of heritable disorders of connective tissue in children with acute rheumatic fever and rheumatic heart disease.

Authors:
Oksana Boyarchuk

Reumatologia 2020 28;58(1):21-25. Epub 2020 Feb 28.

Department of Children's Diseases and Paediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Objectives: Heritable disorders of connective tissue (HDCT) are associated with morphological and functional disorders of different organs and systems. The aim of our study was to determine the clinical signs of heritable disorders of connective tissue and oxyproline levels in children with acute rheumatic fever (ARF) and rheumatic heart disease (RHD).

Material And Methods: A total of 155 patients aged 4 to 17 years participated in the study: 23 with ARF, 78 with RHD, and 54 healthy patients with a history of ARF. Read More

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http://dx.doi.org/10.5114/reum.2020.93509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174797PMC
February 2020

Pulmonary Involvement in Acute Rheumatic Fever: A Case Report and Literature Review.

Cureus 2020 Mar 16;12(3):e7295. Epub 2020 Mar 16.

Department of Pediatric Rheumatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, USA.

Rheumatic pneumonia is a pulmonary complication of rheumatic fever, often with grave outcomes. It has been described sporadically in literature, most recently a decade ago. Here, we describe a case of a 12-year-old Native American girl presenting with chest pain, gastrointestinal complaints, and frequent nosebleeds. Read More

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http://dx.doi.org/10.7759/cureus.7295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163343PMC

An Ethnobotanical Study of Traditional Knowledge and Uses of Medicinal Wild Plants among the Marakwet Community in Kenya.

Evid Based Complement Alternat Med 2020 30;2020:3208634. Epub 2020 Mar 30.

Department of Forestry and Wood Sciences, University of Eldoret, P.O. Box 1125-30100, Eldoret, Kenya.

Traditional plant knowledge and uses of medicinal wild plants were investigated among the Marakwet community in Kenya. Data were collected through interviews with seven traditional healers and 157 questionnaires for local community members. Traditional names of the plants by traditional healers and local community members were prepared as a checklist. Read More

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http://dx.doi.org/10.1155/2020/3208634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149339PMC

Is acute rheumatic fever causally associated with a 6-day antibiotics therapy for pharyngitis?

J Pediatr 2020 Jun 14;221:262. Epub 2020 Apr 14.

Regional Health and Social Agency of Emilia-Romagna, Bologna, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2020.02.083DOI Listing

Intracapsular pressure in children with septic arthritis of the hip.

J Pediatr Orthop B 2020 Apr 13. Epub 2020 Apr 13.

Unit of Orthopaedic Pediatric Surgery, Service of Orthopedic Surgery and Traumatology, Hospital Universitario de Alicante, Alicante, Spain.

Elevated intracapsular pressure in the hip causes occlusion of the retinacular vessels and may result in avascular necrosis of the proximal femoral epiphysis (ANPFE) and growth disturbances. Our goal is to study intraarticular pressure in children with septic arthritis of the hip and its potential correlation with body weight, systemic blood pressure and the volume of synovial fluid aspirated from the joint. Thirteen septic arthritis of the hip were studied. Read More

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http://dx.doi.org/10.1097/BPB.0000000000000727DOI Listing

Early stage Acute B lymphocytic leukemia presenting with symptoms of ankylosing spondylitis (AS): A case report.

Medicine (Baltimore) 2020 Apr;99(15):e19806

College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine.

Rationale: Acute lymphoblastic leukemia (ALL) has acute and severe onset characterized by fever, moderate to severe anemia, bone and joint pain, and sternal tenderness. It is easy to be misdiagnosed as rheumatic disease when joint pain is the first symptom.

Patient Concerns: A male Han, 18 years of age was admitted on July 15th, 2016 for multi-joint swelling and pain with intermittent fever for half a year which had aggravated in the last 10 days. Read More

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http://dx.doi.org/10.1097/MD.0000000000019806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220661PMC