Int J Gynecol Pathol 2021 Jun 9. Epub 2021 Jun 9.
Department of Pathology, Stanford University School of Medicine, Stanford, California (J.J.W., G.W.C., T.A.L.) Department of Pathology, Surrey Memorial Hospital, Surrey, British Columbia, Canada (D.K.).
In the female genital tract, rhabdomyosarcoma may occur in "pure" form or as a heterologous constituent of a biphasic neoplasm such as carcinosarcoma or adenosarcoma. Discriminating rhabdomyosarcoma from its histologic mimics relies on confirmation of skeletal muscle differentiation by morphology or immunohistochemistry (IHC), which can be challenging to interpret in some cases owing to limited expression. PAX7, a transcription factor expressed in mammalian muscle progenitor cells, has been reported in up to 86% of soft tissue rhabdomyosarcomas by IHC. Read More