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Pharmaceuticals (Basel) 2022 Jun 7;15(6). Epub 2022 Jun 7.

S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande 79117-900, MS, Brazil.

Nature presents a wide range of biomolecules with pharmacological potential, including venomous animal proteins. Among the protein components from snake venoms, phospholipases (PLA) are of great importance for the development of new anticancer compounds. Thus, we aimed to evaluate the PLA anticancer properties from venom. Read More

Antioxidants (Basel) 2022 May 28;11(6). Epub 2022 May 28.

Laboratory of Chemistry, Department of Food Science & Human Nutrition, School of Food Biotechnology and Development, Agricultural University of Athens, EU-CONEXUS European University, 11855 Athens, Greece.

L. has various pharmacological properties, known for over 3600 years. These properties are attributed mainly to biologically active substances, which belong to the terpenoid group and include crocins, picrocrocin and safranal. Read More

Pediatr Blood Cancer 2022 Aug 6;69(8):e29532. Epub 2022 Jan 6.

Department of Pediatric Surgery, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.

Background: Outcome of children with bladder-prostate rhabdomyosarcoma (RMS) has improved with multimodal therapies, including surgery and/or radiotherapy for local treatment. Our aim was to report long-term urological complications after a conservative approach combining conservative surgery and brachytherapy.

Patients And Methods: Eighty-six patients, free of disease, were retrospectively reviewed. Read More

Pan Afr Med J 2022 25;41:246. Epub 2022 Mar 25.

Medical Oncology Department, Institut Salah Azaïz, Tunis, Tunisia.

Rhabdomyosarcoma (RMS) is rare in adults. Our study is the first in Tunisia to report outcomes of adult RMS. We retrospectively analyzed clinical data of adult RMS patients. Read More

J Indian Assoc Pediatr Surg 2022 May-Jun;27(3):348-350. Epub 2022 May 12.

Department of Pediatric Surgery, KIMS, Bhubaneswar, Odisha, India.

Hepatobiliary rhabdomyosarcoma (RMS) is a soft tissue malignant musculoskeletal tumor of the biliary tract. It is rare tumor, mostly seen in children and mimics common benign biliary condition. Here, we present a case of 1 year 9 months child of biliary RMS who presented with obstructive jaundice and diagnosed after biopsy. Read More

Pediatr Blood Cancer 2022 Jun 22:e29853. Epub 2022 Jun 22.

Pediatric Oncology Unit, Medical Oncology and Hematology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Background: The prognosis for patients with metastatic rhabdomyosarcoma (RMS) remains largely unsatisfactory despite the adoption of intensive multimodal therapy. To assess the role of different treatments adopted over the years, we retrospectively analyzed a cohort of patients <21 years old with metastatic RMS, treated from 1990 to 2020 at a referral center for pediatric sarcomas.

Methods: Patients were treated using a multimodal approach that included surgery, radiotherapy and chemotherapy (both high-dose chemotherapy and maintenance therapy in some cases). Read More

Pediatr Blood Cancer 2022 Jun 22:e29864. Epub 2022 Jun 22.

Department of Pediatric Surgery, University Hospital Marburg, Baldingerstrasse, 35033, Marburg, Germany.

Background: Cytoreductive surgery (CRS) in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) is an option in advanced peritoneal sarcomatosis. Nevertheless, CRS and HIPEC are not successful in all patients. An enhancement of HIPEC using photodynamic therapy might be beneficial. Read More

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila, Philippines.

Rhabdomyosarcoma is the most common soft-tissue sarcoma in paediatric patients and may arise as a primary orbital neoplasm. Imaging studies show a unilateral solitary orbital lesion. With larger tumours, erosion of the adjacent orbital walls is a common accompanying bony change. Read More

Oncology (Williston Park) 2022 Jun;36(6):375-377

A man, aged 21 years, presented with a 4-month history of progressive swelling of the right testicle. Ultrasound revealed a heterogenous solid mass in the right testicle suspicious for malignancy. Further work-up included CT scans, which identified a 2-cm retroperitoneal lymph node; there was no evidence of thoracic metastases. Read More

Br J Cancer 2022 Jun 17. Epub 2022 Jun 17.

The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, UK.

Background: Ovarian carcinosarcoma (OCS) is an uncommon, biphasic and highly aggressive ovarian cancer type, which has received relatively little research attention.

Methods: We curated the largest pathologically confirmed OCS cohort to date, performing detailed histopathological characterisation, analysis of features associated with survival and comparison against high-grade serous ovarian carcinoma (HGSOC).

Results: Eighty-two OCS patients were identified; overall survival was poor (median 12. Read More

Int J Lab Hematol 2022 Jun 16. Epub 2022 Jun 16.

Hematology Department, Hospital Universitario Cruces, Bizkaia, Spain.

J Steroid Biochem Mol Biol 2022 Jun 13;222:106146. Epub 2022 Jun 13.

Departamento de Biología, Bioquímica y Farmacia, UNS, (8000) Bahía Blanca, Argentina; Instituto de Ciencias Biológicas y Biomédicas del Sur (INBIOSUR), Universidad Nacional del Sur-CONICET, Bahía Blanca, Argentina. Electronic address:

Rhabdomyosarcoma (RMS) is a type of cancer of skeletal muscle. Calcitriol is the active form of vitamin D, also recognised as a steroid hormone called 1α, 25-dihydroxy vitamin D (1,25D). We previously reported that 1,25D promoted cell proliferation and differentiation in non-cancerous skeletal muscle cells C2C12. Read More

J Clin Oncol 2022 Jun 16:JCO2102981. Epub 2022 Jun 16.

Princess Máxima Centre for Paediatric Oncology, Utrecht, the Netherlands.

Purpose: Outcome for patients with metastatic rhabdomyosarcoma (RMS) is poor. This study presents the results of the MTS 2008 study with a pooled analysis including patients from the concurrent BERNIE study.

Patients And Methods: In MTS 2008, patients with metastatic RMS received four cycles of ifosfamide, vincristine, and actinomycin D (IVA) plus doxorubicin, five cycles of IVA, and 12 cycles of maintenance chemotherapy (low-dose cyclophosphamide and vinorelbine). Read More

JAMA Ophthalmol 2022 Jun 16;140(6):e221844. Epub 2022 Jun 16.

Department of Ophthalmology, Wayne & Gladys Valley Center for Vision, University of California, San Francisco, San Francisco.

Int J Surg Pathol 2022 Jun 16:10668969221105622. Epub 2022 Jun 16.

Department of Pathology, Immunology & Laboratory Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Pleomorphic rhabdomyosarcoma (RMS) is an aggressive and rare malignant neoplasm with a poor prognosis. As its name suggests, this tumor exhibits extensive pleomorphism with features of skeletal muscle differentiation. Due to its rarity, its diagnosis is often a clinical and pathological challenge. Read More

Can Urol Assoc J 2022 Jun 9. Epub 2022 Jun 9.

Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

BMJ Case Rep 2022 Jun 14;15(6). Epub 2022 Jun 14.

Radiodiagnosis, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India.

Extraosseous dural-based primary Ewing's sarcoma of the central nervous system is a rare tumour posing a diagnostic challenge. On cross-sectional radiological imaging, the lesion has an extra-axial location with heterogeneous appearance. These lesions are usually multicystic with internal haemorrhage causing fluid-haematocrit levels. Read More

Ethiop J Health Sci 2022 Mar;32(2):313-320

Department of Radiology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Oculo-orbital tumors are frequently encountered pathologies and late diagnosis results in high morbidity and mortality in developing countries. This study aims to assess the computed tomography and magnetic resonance imaging patterns of pediatric oculo-orbital tumors with particular emphasis on retinoblastoma and compare agreement between imaging and histopathology diagnosis.

Methods: A retrospective analysis of 101 pediatric patients with oculo-orbital lesions from February 2017 to January 2020 at Tikur Anbessa Specialized Hospital oncology center. Read More

Front Oncol 2022 25;12:864790. Epub 2022 May 25.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States.

Objective: Children and adolescents with recurrent and metastatic solid tumors have a poor outcome. A previous phase 1 study (ANGIO1) targeting angiogenesis with bevacizumab, sorafenib, and cyclophosphamide, demonstrated a signal of activity in a subset of patients. Here we report the results of a cohort of pediatric and young adult patients treated at the recommended phase 2 doses. Read More

Zhonghua Yi Xue Za Zhi 2022 May;102(20):1500-1505

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

To analyze the efficacy and prognostic factors in children with parameningeal rhabdomyosarcoma (PMRMS) treated by I brachytherapy combined with chemotherapy. A retrospective analysis of the clinical data of 33 pediatric patients treated with I brachytherapy combined with chemotherapy in Peking University Stomatological Hospital from July 2013 to October 2018 was carried out to analyze the efficacy and prognostic factors. Among the 33 patients, 19 were males and 14 were females; the median age was 4 years old (1-12 years old). Read More

Asian J Surg 2022 Jun 9. Epub 2022 Jun 9.

Department of Gynecology, Second Hospital of Lanzhou University, Lanzhou, Gansu, China. Electronic address:

Lancet Child Adolesc Health 2022 Jun 8. Epub 2022 Jun 8.

Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands.

Background: Adolescent and young adult patients with rhabdomyosarcoma often have poorer outcomes than do children. We aimed to compare the findings of adolescent and young adult patients with children enrolled in two prospective clinical protocols.

Methods: This retrospective observational analysis was based on data from the European paediatric Soft tissue sarcoma Study Group (EpSSG) rhabdomyosarcoma 2005 trial (phase 3 randomised trial for localised rhabdomyosarcoma, open from April, 2006, to December, 2016) and the EpSSG MTS 2008 protocol (prospective, observational, single-arm study for metastatic rhabdomyosarcoma, open from June, 2010, to December, 2016), which involved 108 centres from 14 different countries in total. Read More

Lancet Child Adolesc Health 2022 Jun 8. Epub 2022 Jun 8.

Hospital of the State Capital Stuttgart gKAöR, Center for Pediatric, Adolescent and Women's Medicine, Central location (Olgahospital), D-70174 Stuttgart, Germany. Electronic address:

Front Oncol 2022 24;12:887210. Epub 2022 May 24.

Research Department, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.

Virtually every cell in the body releases extracellular vesicles (EVs), the contents of which can provide a "fingerprint" of their cellular origin. EVs are present in all bodily fluids and can be obtained using minimally invasive techniques. Thus, EVs can provide a promising source of diagnostic, prognostic, and predictive biomarkers, particularly in the context of cancer. Read More

Cancers (Basel) 2022 May 25;14(11). Epub 2022 May 25.

West German Proton Therapy Centre Essen, 45147 Essen, Germany.

Background And Purpose: Interfractional anatomical changes might affect the outcome of proton therapy (PT). We aimed to prospectively evaluate the role of Magnetic Resonance Imaging (MRI) based adaptive PT for children with tumors of the head and neck and base of skull.

Methods: MRI verification images were acquired at half of the treatment course. Read More

Zhonghua Bing Li Xue Za Zhi 2022 Jun;51(6):545-547

Department of Pathology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou 350014, China.

Cureus 2022 May 6;14(5):e24786. Epub 2022 May 6.

Urology, Royal Commission Yanbu Medical Centre, Yanbu, SAU.

The majority of patients with paratesticular rhabdomyosarcoma (RMS) present in the pediatric age group with a unilateral, painless, palpable scrotum mass. By contrast, cases of RMS presenting as painful edema are rare. We present a case of alveolar paratesticular RMS in a 30-year-old man who had been suffering from a painful swelling of the scrotum on the left side for two years and a preceding mass four months before visiting the clinic. Read More

Eur J Cancer 2022 Jul 4;170:196-208. Epub 2022 Jun 4.

Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Department of Pharmaceutical Sciences, University Utrecht, Utrecht, Netherlands. Electronic address:

Background: Childhood cancer is still a leading cause of death around the world. To improve outcomes, there is an urgent need for tailored treatment. The systematic evaluation of existing preclinical data can provide an overview of what is known and identify gaps in the current knowledge. Read More

Brain Tumor Pathol 2022 Jun 6. Epub 2022 Jun 6.

Neuropathology Section, Department of Pathology and Molecular Medicine/Neuropathology, Hamilton General Hospital, McMaster University, 237 Barton Street, Hamilton, ON, L8L 2X2, Canada.

A child had been followed since infancy by our multi-disciplinary neuro-oncology clinic with annual magnetic resonance imaging (MRI) under the presumed diagnosis of encephalocraniocutaneous lipomatosis (ECCL), with clinical features including nevus psiloliparus, scalp lipoma, nodular skin tag on and coloboma of the eyelid, cortical atrophy and meningeal angiomatosis. At the age of 4, she was found to have a large temporoparietal lesion causing elevated intracranial pressure requiring surgical resection. Histopathological exam of the tumor was suggestive of an intracranial sarcoma. Read More