9,165 results match your criteria Rhabdomyolysis


Transient left ventricular dysfunction associated with severe infection.

J Cardiol Cases 2011 Apr 18;3(2):e78-e81. Epub 2011 Feb 18.

Division of Cardiology, Niigata University School of Medical and Dental Sciences, Niigata, Japan.

infection, although commonly seen as pneumonia, can also manifest systemic involvement. Here, we describe a case of sporadic infection coinciding with pneumonia, rhabdomyolysis, renal failure, and severe left ventricular dysfunction, which subsequently developed refractory septic shock. An endomyocardial biopsy revealed no findings of interstitial inflammatory infiltrates. Read More

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Multifactorial Origin of Exertional Rhabdomyolysis, Recurrent Hematuria, and Episodic Pain in a Service Member with Sickle Cell Trait.

Case Rep Genet 2018 7;2018:6898546. Epub 2018 Nov 7.

Consortium for Health and Military Performance, Department of Military and Emergency Medicine, Hébert School of Medicine, Uniformed Services University, 4301 Jones Bridge Rd., Bethesda, MD 20184, USA.

Individuals with Sickle Cell Trait (SCT), generally considered a benign carrier state of hemoglobin S (HbAS), are thought to be at risk for exertional rhabdomyolysis and hematuria, conditions that can also be caused by various other acquired and inherited factors. We report an SCT positive service member with an exertional rhabdomyolysis event, recurrent hematuria with transient proteinuria, and episodic burning pain in the lower extremities. Clinical and genetic studies revealed the multifactorial nature of his complex phenotype. Read More

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November 2018

A Fatal Case of Acute Renal Failure From Envenoming Syndrome After Massive Bee Attack: A Case Report and Literature Review.

Authors:
Rhome L Hughes

Am J Forensic Med Pathol 2018 Dec 6. Epub 2018 Dec 6.

From the University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND.

Envenoming syndrome is a systemic toxic reaction to the inoculation of large volume of insect venom, typically after a swarm attack from bees. Africanized honey bees are notorious for their aggressive nature, and human deaths resulting from Africanized honey bee attacks are consistently reported. Whereas anaphylaxis is the most common lethal mechanism of injury, delayed deaths can also occur as a consequence of severe venom toxicity with resultant end organ damage. Read More

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December 2018

Survival After Cardiac Arrest With Instantaneous Rigorlike Stiffness: A Case Report.

Ann Emerg Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Emergency Medicine and Critical Care, Japanese Red Cross Society Kyoto Daini Hospital, Kyoto, Japan.

Instantaneous rigor is the immediate appearance of rigor mortis after cardiac arrest. To our knowledge, no previous reports exist on resuscitation of such patients. A young athlete suddenly collapsed with cardiac arrest during a marathon; his legs stiffened with instantaneous rigorlike stiffness. Read More

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December 2018

Atypical and severe manifestations of chikungunya virus infection in French Guiana: A hospital-based study.

PLoS One 2018 6;13(12):e0207406. Epub 2018 Dec 6.

Tropical and Infectious Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Background: French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed to describe the clinical presentation of patients hospitalized for CHIKV infection, to estimate and identify risk factors of unusual and severe forms in adult patients. Read More

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December 2018
1 Read

[Simvastatin-Induced Myopathy after Dose Increase].

Dtsch Med Wochenschr 2018 Dec 3;143(24):1791-1794. Epub 2018 Dec 3.

Klinik für Geriatrie mit Neurologie und Tagesklinik, Johanniter-Krankenhaus Bonn, Johanniter GmbH.

History And Clinical Findings:  We present a 86-year-old patient who suffered from progressive weakness in his right leg. Due to a hypercholesterinemia he had received Simvastatin for a few years. Because of higher cholesterine levels the dosis had been increased from 40 to 80 mg 6 months ago. Read More

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December 2018

Histological manifestations of rhabdomyolysis in the kidney.

Nephrol Dial Transplant 2018 Dec;33(12):2113-2114

Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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December 2018

DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury.

Nat Biomed Eng 2018 Nov 8;2(11):865-877. Epub 2018 Nov 8.

Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.

Patients with acute kidney injury (AKI) frequently require kidney transplantation and supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled DNA origami nanostructures (DONs) with rectangular, triangular and tubular shapes accumulate preferentially in the kidneys of healthy mice and mice with rhabdomyolysis-induced AKI, and that rectangular DONs have renal-protective properties, with efficacy similar to the antioxidant -acetylcysteine-a clinically used drug that ameliorates contrast-induced AKI and protects kidney function from nephrotoxic agents. We evaluated the biodistribution of DONs non-invasively via positron emission tomography, and the efficacy of rectangular DONs in the treatment of AKI via dynamic positron emission tomography imaging with Ga-EDTA, blood tests and kidney tissue staining. Read More

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November 2018

Pemetrexed-induced severe rhabdomyolysis in lung cancer: A case report.

J Oncol Pharm Pract 2018 Nov 30:1078155218816767. Epub 2018 Nov 30.

1 Northwell Health Cancer Institute, Monter Cancer Center, Lake Success, NY.

Pemetrexed is an antifolate metabolite used to treat non-small cell lung cancer in the adjuvant and advanced setting. It is commonly known to cause rash, diarrhea, fatigue, mucositis, and myelosuppression. We report a case of a patient receiving adjuvant cisplatin and pemetrexed for non-small cell lung adenocarcinoma and experienced severe rhabdomyolysis. Read More

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November 2018

Rhabdomyolysis-Induced Acute Kidney Injury in Diabetic Emergency: Underdiagnosed and an Important Association to Be Aware of.

Case Rep Med 2018 31;2018:4132738. Epub 2018 Oct 31.

Department of Medicine, Internal Medicine Residency Program, Hackensack Meridian Health, Jersey Shore University Medical Center, Neptune, New Jersey 07753, USA.

Rhabdomyolysis is a potentially life-threatening clinical syndrome associated with muscle injury which can cause a leakage of intracellular contents, manifested from the range of being asymptomatic to a life-threatening condition causing acute kidney injury and severe electrolyte abnormalities. Rhabdomyolysis has been associated with both diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic nonketotic syndrome, though there is an increased association with rhabdomyolysis and acute kidney injury with hyperosmolar nonketonic state compared with patients with diabetic ketoacidosis. Common clinical manifestations are muscle pain, dark urine, and generalized weakness. Read More

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October 2018

An Out-of-Season Case of Coxsackie B Myocarditis with Severe Rhabdomyolysis.

Case Rep Infect Dis 2018 30;2018:4258296. Epub 2018 Oct 30.

Internal Medicine Residency Program, Mount Sinai Hospital, Chicago, IL, USA.

A 21-year-old woman was found to have fulminant myocarditis as a result of Coxsackie B infection (a virus shown to exhibit summer-fall seasonality) in mid-December. In this case report, seasonality of enteroviruses is examined, as well as additional factors which may contribute to sporadic cases during winter months. The case report also discusses clinical criteria for endomyocardial biopsy, utility of PCR vs. Read More

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October 2018

Oxymetholone-Induced Acute Renal Failure: A Case Report.

Caspian J Intern Med 2018 ;9(4):410-412

Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Comprehensive cancer center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: The prevalence of using anabolic steroids such as oxymetholone is increasing. This highlights the need for closely monitoring side effects of this drug. Acute renal failure (ARF) has been reported as a complication of rhabdomyolysis in anabolic steroids users. Read More

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January 2018
3 Reads

Total tiroidectomy in patient with McArdle's syndrome: Anesthetic management.

Rev Esp Anestesiol Reanim 2018 Nov 30. Epub 2018 Nov 30.

Servicio de Anestesiología y Reanimación, Hospital de Jerez de la Frontera, Jerez de la Frontera (Cádiz), España.

McArdle disease or type V glycogenosis is a rare metabolic myopathy consisting of muscle loss and weakness. These patients have risks associated with anaesthesia. They can present with hypoglycaemia, rhabdomyolysis, acute renal failure, and electrolyte changes. Read More

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November 2018
1 Read

Are extreme conditioning programmes effective and safe? A narrative review of high-intensity functional training methods research paradigms and findings.

BMJ Open Sport Exerc Med 2018 2;4(1):e000435. Epub 2018 Nov 2.

Laboratory of Exercise Physiology, Faculty Estacio of Vitoria, Vitoria, Brazil.

Extreme conditioning programmes (ECPs, eg, CrossFit, Insanity and Gym Jones) are a growing fitness regimen characterised by functional movements performed at high-intensity and with constantly varying movements. While the popularity and number of practitioners of ECPs are growing, a debate has been established between what is observed in the scientific literature and anecdotal reports from athletes, coaches and physicians about safety (incidence and prevalence of injuries and rhabdomyolysis) and benefits (physical and mental health). In this article, we review the prevalence and incidence of injuries, rhabdomyolysis, physiological responses and chronic adaptations to ECPs. Read More

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November 2018
1 Read

Safety and tolerability of high intensity statin therapy in heart transplant patients receiving immunosuppression with tacrolimus.

Clin Transplant 2018 Nov 28:e13454. Epub 2018 Nov 28.

University of North Carolina Medical Center -, Department of Pharmacy.

Background: Following heart transplantation (HT), HMG CoA reductase inhibitors (statins) have been shown to reduce total and low-density lipoprotein (LDL) cholesterol, development of cardiac allograft vasculopathy (CAV), and mortality. Studies in HT patients have demonstrated the safety of low/moderate intensity statins, however little data exists using high intensity (HI) statins. The study aim was to evaluate the safety and efficacy of HI statins in HT recipients receiving tacrolimus. Read More

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November 2018
2 Reads

Ezetimibe for the prevention of cardiovascular disease and all-cause mortality events.

Cochrane Database Syst Rev 2018 11 19;11:CD012502. Epub 2018 Nov 19.

Pharmacy Department, First Affiliated Hospital of Third Military Medical University (Army Medical University), 30 Gaotanyan Street, Shapingba District, Chongqing, China, 400038.

Background: Cardiovascular disease (CVD) remains an important cause of mortality and morbidity, and high levels of blood cholesterol are thought to be the major modifiable risk factors for CVD. The use of statins is the preferred treatment strategy for the prevention of CVD, but some people at high-risk for CVD are intolerant to statin therapy or unable to achieve their treatment goals with the maximal recommended doses of statin. Ezetimibe is a selective cholesterol absorption inhibitor, whether it has a positive effect on CVD events remains uncertain. Read More

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November 2018
5 Reads

Lipid Myopathies.

J Clin Med 2018 Nov 23;7(12). Epub 2018 Nov 23.

Unit of Neuromuscular Diseases, Department of Neurology, Mental Health and Sensory Organs (NESMOS), SAPIENZA University of Rome, Sant' Andrea Hospital, 00189 Rome, Italy.

Disorders of lipid metabolism affect several tissues, including skeletal and cardiac muscle tissues. Lipid myopathies (LM) are rare multi-systemic diseases, which most often are due to genetic defects. Clinically, LM can have acute or chronic clinical presentation. Read More

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November 2018
2 Reads

Necrotizing Autoimmune myopathy: A case report on statin induced rhabdomyolysis requiring immunosuppressive therapy.

Drug Discov Ther 2018 ;12(5):315-317

Department of Internal Medicine, Creighton University School of Medicine.

Statins can cause a wide spectrum of muscular adverse effects ranging from asymptomatic elevation of Creatine Kinase (CK), myalgia and exercise intolerance to rhabdomyolysis. Most of these effects generally resolve on stopping the medication. However, statins can be associated with a unique autoimmune myopathy wherein symptoms persist or even progress after statin discontinuation and require immunosuppressive therapy. Read More

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January 2018
7 Reads

Malignant hyperthermia.

Handb Clin Neurol 2018 ;157:645-661

Malignant Hyperthermia Investigation Unit, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.

Malignant hyperthermia (MH) is a form of heat illness caused by increased heat generation exceeding the body's capacity for heat loss. It is classified separately from other forms of heat illness as the latter require assessment of mental function for differential diagnosis. This is not possible with MH which occurs during general anesthesia when mental function cannot be assessed. Read More

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January 2018
1 Read

Phenotype of carnitine palmitoyltransferase II (CPT II) deficiency: A questionnaire-based survey.

J Clin Neurosci 2018 Nov 16. Epub 2018 Nov 16.

Department of Neurology, Martin-Luther-University Halle-Wittenberg, Germany.

Wide spectrums of symptoms besides muscle weakness, different triggering factors and varied muscles involvement are associated with CPT II deficiency. However, systematic clinical characterization of CPT II deficiency is not known. A Questionnaire-based retrospective study on 13 biochemically and genetically confirmed CPT II deficient patients was performed to analyze these aspects. Read More

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November 2018
5 Reads

Outbreak of Haff disease caused by consumption of crayfish (Procambarus clarkii) in nanjing, China.

Clin Toxicol (Phila) 2018 Nov 17:1-7. Epub 2018 Nov 17.

a Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health , Southeast University , Nanjing , China.

Context: This paper reports a detailed epidemiological investigation of a large Haff disease outbreak in Nanjing, China, including laboratory analysis of water, river sediment, and fish.

Methods: Structured questionnaires were administered to all case-patients. An unmatched case-control study was conducted to identify the factors affecting the incidence of Haff disease. Read More

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November 2018
5 Reads

Medical Expenditures Among Medicare Beneficiaries with Statin-Associated Adverse Effects Following Myocardial Infarction.

Cardiovasc Drugs Ther 2018 Dec;32(6):601-610

Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Purpose: Compare medical expenditures among adults with statin-associated adverse effects (SAAE) and high statin adherence (HSA) following myocardial infarction (MI).

Methods: We analyzed expenditures in 2016 US dollars among Medicare beneficiaries with SAAE (n = 1741) and HSA (n = 55,567) who were ≥ 66 years of age and initiated moderate/high-intensity statins following an MI in 2007-2013. SAAE were identified through a claims-based algorithm, which included down-titrating statins and initiating ezetimibe, switching to ezetimibe monotherapy, having a rhabdomyolysis or antihyperlipidemic adverse event followed by statin down-titration or discontinuation, or switching between ≥ 3 statin types within 365 days following MI. Read More

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December 2018
1 Read

Onset timing of statin-induced musculoskeletal adverse events and concomitant drug-associated shift in onset timing of MAEs.

Pharmacol Res Perspect 2018 Dec 7;6(6):e00439. Epub 2018 Nov 7.

Department of Analytical Pharmaceutics and Informatics Faculty of Pharmacy and Pharmaceutical Sciences Josai University Sakado Saitama Japan.

To evaluate the onset timing of musculoskeletal adverse events (MAEs) that develop during statin monotherapy and to determine whether concomitant drugs used concurrently with statin therapy shifts the onset timing of MAEs. Cases in which statins (atorvastatin, rosuvastatin, simvastatin, lovastatin, fluvastatin, pitavastatin, and pravastatin) were prescribed were extracted from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) Data Files. The onset timing of MAEs during statin monotherapy was evaluated by determining the difference between statin start date and MAE onset date. Read More

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December 2018

A novel synthetic cannabinoid (Cumyl-4-cyano-BINACA) resulting in hyperthermia, rhabdomyolysis, and renal failure in a 29-year-old patient: it's not meningitis.

Clin Toxicol (Phila) 2018 Nov 15:1-2. Epub 2018 Nov 15.

a Department of Emergency Medicine , Emory University School of Medicine , Atlanta , GA , USA.

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November 2018
3.120 Impact Factor

Mushroom poisoning: A proposed new clinical classification.

Toxicon 2018 Nov 12;157:53-65. Epub 2018 Nov 12.

Dept. for Clinical Toxicology at II, Med. Klinik, TU, München, Munich, Germany.

Mushroom poisoning is a significant and increasing form of toxin-induced-disease. Existing classifications of mushroom poisoning do not include more recently described new syndromes of mushroom poisoning and this can impede the diagnostic process. We reviewed the literature on mushroom poisoning, concentrating on the period since the current major classification published in 1994, to identify all new syndromes of poisoning and organise them into a new integrated classification, supported by a new diagnostic algorithm. Read More

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November 2018
10 Reads

The case-crossover design for drug-drug interactions: considerations for implementation.

Epidemiology 2018 Nov 14. Epub 2018 Nov 14.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Background: The case-crossover design may be useful for evaluating the clinical impact of drug-drug interactions in electronic healthcare data; however, experience with the design in this context is limited.

Methods: Using US healthcare claims data (1994-2013), we evaluated two examples of interacting drugs with prior evidence of harm: (1) cytochrome P450 (CYP)3A4-metabolized statins + clarithromycin or erythromycin and rhabdomyolysis; and (2) clopidogrel + fluoxetine or fluvoxamine and ischemic events. We conducted case-crossover analyses with (1) a three-parameter model with a product term and a six-parameter saturated model that distinguished initiation order of the two drugs; and (2) with or without active comparators. Read More

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November 2018

Osmolality Selectively Offsets the Impact of Hyperthermia on Mouse Skeletal Muscle .

Front Physiol 2018 31;9:1496. Epub 2018 Oct 31.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States.

Hyperthermia and dehydration can occur during exercise in hot environments. Nevertheless, whether elevations in extracellular osmolality contributes to the increased skeletal muscle tension, sarcolemmal injury, and oxidative stress reported in warm climates remains unknown. We simulated osmotic and heat stress, , in mouse limb muscles with different fiber compositions. Read More

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October 2018

The Yellow Knight Fights Back: Toxicological, Epidemiological, and Survey Studies Defend Edibility of .

Toxins (Basel) 2018 Nov 13;10(11). Epub 2018 Nov 13.

Department of Environmental Medicine, Poznan University of Medical Sciences, 60-806 Poznan, Poland.

Rhabdomyolysis, a condition associated with the consumption of Yellow Knight mushrooms (), was first reported in 2001. In response, some countries began to consider the mushroom as poisonous, whereas in others it is still consumed. In the present study, a nationwide survey of Polish mushroom foragers ( = 1545) was conducted to estimate the frequency of consumption. Read More

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November 2018

Rhabdomyolysis among Critically Ill Combat Casualties: Long-Term Outcomes.

Am J Nephrol 2018 14;48(6):399-405. Epub 2018 Nov 14.

David Grant USAF Medical Center, Fairfield, California,

Background: Although rhabdomyolysis has been associated with acute kidney injury and mortality in the short term, the long-term consequences of an episode of rhabdomyolysis remain unknown. We sought to identify the long-term outcomes of rhabdomyolysis, including mortality, renal function, and incidence of hypertension (HTN), among service members initially admitted to the intensive care unit after sustaining a combat injury in Iraq or Afghanistan between February 1, 2002 and February 1, 2011.

Methods: Information on age, sex, injury severity score, mechanism of injury, serum creatinine, burn injury, presenting mean arterial pressure, and creatine kinase were retrospectively collected and analyzed for 2,208 patients. Read More

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November 2018
3 Reads

Acute Flaccid Paralysis in an 11-Year-Old.

Pediatr Emerg Care 2018 Nov 12. Epub 2018 Nov 12.

Rhabdomyolysis is a syndrome caused by injury to skeletal muscle and subsequent release of intracellular components into the systemic circulation. We report a case of rhabdomyolysis causing acute paralysis from underlying and unrecognized hypothyroidism in an 11-year-old girl. To date, publications of rhabdomyolysis secondary to hypothyroidism have been limited, especially in the pediatric population. Read More

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November 2018
4 Reads

Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.

EMBO J 2018 Nov 12. Epub 2018 Nov 12.

Institut Necker-Enfants Malades, Paris, France

As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss of function of the LPIN1 gene frequently lead to severe rhabdomyolysis bouts in children, though the metabolic alterations and possible therapeutic interventions remain elusive. Here, we show that lipin1 deficiency in mouse skeletal muscles is sufficient to trigger myopathy. Read More

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November 2018
3 Reads
10.434 Impact Factor

[A case of severe organophosphorus poisoning complicated with rhabdomyolysis].

Authors:
Y F Cai Y C Wang

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2018 Sep;36(9):688

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September 2018

Propofol infusion-like syndrome in a dog.

Can Vet J 2018 Nov;59(11):1216-1222

Department of Emergency and Critical Care, VCA West Los Angeles Animal Hospital, Los Angeles, California, USA.

An 8-year-old, spayed female Chihuahua mixed breed dog was presented for dyspnea and was subsequently mechanically ventilated. Propofol was utilized as part of the anesthetic protocol. The dog developed rhabdomyolysis, myoglobinuria, cardiac arrhythmias, liver enzyme elevation, and methemoglobinemia. Read More

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November 2018
2 Reads

Rhabdomyolysis during myelosuppression in a patient with central nervous system leukemia: A case report.

Medicine (Baltimore) 2018 Nov;97(45):e13091

Hematology Department, First Affliated Hospital, Guangxi Medical University, Nanning, China.

Rationale: Rhabdomyolysis is a potentially life-threatening syndrome and is a rare complication in patients with acute leukemia.

Patient's Concerns: A 20-year-old male was admitted to our hospital due to skin ecchymosis in his trunk and lower limbs for 10 days.

Diagnoses: Based on the precise diagnosis of leukemia, namely cell morphology, immunology, cytogenetics, and molecular biological typing (MICM), the patient was diagnosed with acute T-lymphocytic leukemia (T-ALL). Read More

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November 2018

Ryanodine Receptor 1-Related Myopathies: Diagnostic and Therapeutic Approaches.

Neurotherapeutics 2018 Oct;15(4):885-899

Neuromuscular Symptoms Unit, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.

Ryanodine receptor type 1-related myopathies (RYR1-RM) are the most common class of congenital myopathies. Historically, RYR1-RM classification and diagnosis have been guided by histopathologic findings on muscle biopsy. Main histological subtypes of RYR1-RM include central core disease, multiminicore disease, core-rod myopathy, centronuclear myopathy, and congenital fiber-type disproportion. Read More

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October 2018
3 Reads

A case report of scrub typhus complicated with myocarditis and rhabdomyolysis.

BMC Infect Dis 2018 Nov 7;18(1):551. Epub 2018 Nov 7.

Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.

Background: Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi, a gram-negative intracellular bacterium. Myocarditis and rhabdomyolysis are rare complications of scrub typhus.

Case Presentation: We report a case of scrub typhus, which was simultaneously complicated with myocarditis and rhabdomyolysis. Read More

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November 2018
1 Read

Management and diagnosis of mitochondrial fatty acid oxidation disorders: focus on very-long-chain acyl-CoA dehydrogenase deficiency.

J Hum Genet 2018 Nov 6. Epub 2018 Nov 6.

Department of Pediatrics, Shimane University Faculty of Medicine, 89-1, Ennya, Izumo, Shimane, 693-8501, Japan.

Mitochondrial fatty acid oxidation disorders (FAODs) are caused by defects in β-oxidation enzymes, including very long-chain acyl-CoA dehydrogenase (VLCAD), trifunctional protein (TFP), carnitine palmitoyltransferase-2 (CPT2), carnitine-acylcarnitine translocase (CACT) and others. During prolonged fasting, infection, or exercise, patients with FAODs present with hypoglycemia, rhabdomyolysis, cardiomyopathy, liver dysfunction, and occasionally sudden death. This article describes the diagnosis, newborn screening, and treatment of long-chain FAODs with a focus on VLCAD deficiency. Read More

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November 2018
18 Reads

Safety and Efficacy of Retroperitoneoscopic Living Donor Nephrectomy: Comparison of Early Complication, Donor and Recipient Outcome with Hand-Assisted Laparoscopic Living Donor Nephrectomy.

J Endourol 2018 Nov 6. Epub 2018 Nov 6.

Hokkaido University Hospital, Urology, Sapporo, Japan ;

Introduction: Laparoscopic surgery has been a standard procedure of living donor nephrectomy. Transperitoneal hand-assisted laparoscopic living donor nephrectomy (HALDN) has been commonly reported by many centers with excellent outcome. However, there are few studies reporting retroperitoneoscopic living donor nephrectomy (RPLDN). Read More

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November 2018
3 Reads

Myopathies Related to Glycogen Metabolism Disorders.

Neurotherapeutics 2018 Oct;15(4):915-927

Division of Neuromuscular & Neurometabolic Disorders, Departments of Pediatrics and Medicine, McMaster University, Hamilton Health Sciences Centre, Rm 2H26, Hamilton, ON, L8S 4L8, Canada.

Most of the glycogen metabolism disorders that affect skeletal muscle involve enzymes in glycogenolysis (myophosphorylase (PYGM), glycogen debranching enzyme (AGL), phosphorylase b kinase (PHKB)) and glycolysis (phosphofructokinase (PFK), phosphoglycerate mutase (PGAM2), aldolase A (ALDOA), β-enolase (ENO3)); however, 3 involve glycogen synthesis (glycogenin-1 (GYG1), glycogen synthase (GSE), and branching enzyme (GBE1)). Many present with exercise-induced cramps and rhabdomyolysis with higher-intensity exercise (i.e. Read More

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October 2018
9 Reads

Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate.

Am J Nephrol 2018 2;48(5):339-348. Epub 2018 Nov 2.

University of Colorado, Renal Diseases and Hypertension, Aurora, Colorado, USA.

Background: Heat stress and rhabdomyolysis are major risk factors for the occurrence of repeated acute kidney injury in workers exposed to heat and strenuous work. These episodes, in turn, may progress to chronic kidney disease.

Objective: The purpose of this study was to test the effect of allopurinol (AP) and sodium bicarbonate on the kidney injury induced by recurrent heat stress dehydration with concomitant repeated episodes of rhabdomyolysis. Read More

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November 2018
1 Read

HyperCKemia associated with lacosamide therapy in an elderly patient with focal onset epilepsy.

Seizure 2018 Dec 15;63:14-16. Epub 2018 Oct 15.

National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, 886 Urushiyama, Aoi-ku, Shizuoka 420-8688, Japan. Electronic address:

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December 2018

Letter to the editor: phenytoin-induced rhabdomyolysis.

Acta Neurol Belg 2018 Nov 2. Epub 2018 Nov 2.

Department of Neurology, AZ Maria Middelares, Buitenring Sint-Denijs 30, 9000, Ghent, Belgium.

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November 2018

Clinical Outcomes Associated With Sickle Cell Trait: A Systematic Review.

Ann Intern Med 2018 Nov 30;169(9):619-627. Epub 2018 Oct 30.

Vascular Medicine Institute at the University of Pittsburgh, Pittsburgh, Pennsylvania (G.J.K.).

Background: Although sickle cell trait (SCT) is largely a benign carrier state, it may increase risk for certain clinical outcomes.

Purpose: To evaluate associations between SCT and clinical outcomes in children and adults.

Data Sources: English-language searches of PubMed, CINAHL, the Cochrane Library, Current Contents Connect, Scopus, and Embase (1 January 1970 to 30 June 2018) and bibliographies of review articles. Read More

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November 2018
5 Reads

Extrarenal manifestations of the hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli (STEC HUS).

Pediatr Nephrol 2018 Nov 1. Epub 2018 Nov 1.

Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.

Hemolytic uremic syndrome is commonly caused by Shiga toxin-producing Escherichia coli (STEC). Up to 15% of individuals with STEC-associated hemorrhagic diarrhea develop hemolytic uremic syndrome (STEC HUS). Hemolytic uremic syndrome (HUS) is a disorder comprising of thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney injury. Read More

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November 2018
14 Reads

Takotsubo syndrome triggered by emotional and physical stress due to coincidental immobilization resembling the experimental model of the disease - a case report.

Pol Merkur Lekarski 2018 Oct;45(268):154-157

Department of Internal Medicine, Józef Struś Hospital.

The term takotsubo syndrome (TTS) is derived from a comparison of left ventricular (LV) appearance in its apical form to the shape of the pot which is a trap used for octopus catching. In the classical animal model on rats, its occurrence can be triggered by experimental immobilization (IMO). Former observations of capture myopathy, seen in animals after extreme exertion, showed coexistence of rhabdomyolysis related to skeletal muscle injury and myocardial damage. Read More

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October 2018
5 Reads

A 4-Year Analysis of the Incidence of Injuries Among CrossFit-Trained Participants.

Orthop J Sports Med 2018 Oct 24;6(10):2325967118803100. Epub 2018 Oct 24.

Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.

Background: High-intensity functional training (HIFT) is a new training modality that merges high-intensity exercise with functional (multijoint) movements. Even though others exist, CrossFit training has emerged as the most common form of HIFT. Recently, several reports have linked CrossFit training to severe injuries and/or life-threatening conditions, such as rhabdomyolysis. Read More

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October 2018
11 Reads

Real-World Data to Identify Hypercholesterolemia Patients on Suboptimal Statin Therapy.

J Atheroscler Thromb 2018 Oct 26. Epub 2018 Oct 26.

Teikyo Academic Research Center.

Aim: Statins are generally well-tolerated but some patients develop adverse events and down-titrate or discontinue statins. It is important to understand the frequency of dyslipidemia patients with the inability to continue statins. The aim of the present study was to identify the frequency of high-risk dyslipidemia patients who are unable to take or not taking statins for any reason using Japanese hospital claims database. Read More

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October 2018