9,312 results match your criteria Rhabdomyolysis


Loxoscelism: Cutaneous and Hematologic Manifestations.

Adv Hematol 2019 20;2019:4091278. Epub 2019 Mar 20.

Department of Hematology and Oncology, West Cancer Clinic, 7945 Wolf River Blvd, Germantown, TN 38138, USA.

Background: Brown recluse spider (BRS) envenomation can lead to significant morbidity through severe local reaction and systemic illness including acute hemolytic anemia, rhabdomyolysis, disseminated intravascular coagulopathy (DIC), and even death. We aim to describe the clinical features and the roles of antibiotics and steroids in the treatment of loxoscelism.

Methods: We retrospectively identified nine patients (pts) at our institution who were admitted with moderate to severe loxoscelism. Read More

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http://dx.doi.org/10.1155/2019/4091278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446102PMC

Unique Presentation of an Inflammatory Abdominal Aortic Aneurysm With Rhabdomyolysis.

EJVES Short Rep 2019 7;43:1-3. Epub 2019 Apr 7.

Department of Vascular Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Objective: This study reports the case of a 72 year old male who presented with rhabdomyolysis and a symptomatic juxtarenal inflammatory abdominal aortic aneurysm (IAAA). He underwent open repair of his IAAA with a polytetrafluoroethylene graft using the transperitoneal approach.

Results: The patient's aneurysm had significant inflammation with a thick rind of friable tissue overlying the native aorta. Read More

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http://dx.doi.org/10.1016/j.ejvssr.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462796PMC

Chikungunya Virus Infection-related Rhabdomyolysis: A Case Report.

Cureus 2019 Feb 8;11(2):e4036. Epub 2019 Feb 8.

Internal Medicine, Beth Israel Deaconess Medical Center, Boston, USA.

Chikungunya virus infection is an infection transmitted by mosquitoes. It classically presents with fever and arthralgia. The rhabdomyolysis as a complication of this infection is rarely reported in the literature. Read More

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http://dx.doi.org/10.7759/cureus.4036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456360PMC
February 2019

In silico prediction of drug-induced rhabdomyolysis with machine-learning models and structural alerts.

J Appl Toxicol 2019 Apr 21. Epub 2019 Apr 21.

Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.

Drug-induced rhabdomyolysis (DIR) is a serious adverse reaction and can be fatal. In the present study, we focused on the modeling and understanding of the molecular basis of DIR of small molecule drugs. A series of machine-learning models were developed using an Online Chemical Modeling Environment platform with a diverse dataset. Read More

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http://dx.doi.org/10.1002/jat.3808DOI Listing

Severe rhabdomyolysis related to oxaliplatin adjuvant therapy for colorectal cancer.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Medical Oncology, Hospital de São Francisco Xavier, Lisbon, Lisbon, Portugal.

Colorectal cancer is the third most common cancer in men and the second in women. The standard chemotherapy regiment in stage III colon cancer is based in oxaliplatin. The most common side effects include neutropenia, peripheral neuropathy, vomiting and diarrhoea. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22867
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http://dx.doi.org/10.1136/bcr-2018-228673DOI Listing
April 2019
2 Reads

Impaired fat oxidation during exercise in Long-Chain Acyl-CoA Dehydrogenase Deficiency patients and effect of IV-glucose.

J Clin Endocrinol Metab 2019 Apr 16. Epub 2019 Apr 16.

Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, Copenhagen Denmark.

Context: Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) affects oxidation of long-chain fatty acids (FAO) and is associated with risk of metabolic crises and episodic rhabdomyolysis.

Case Description: We present two patients with LCHADD. Patient 1 (male, 26 years) was severely affected by muscle weakness and neuropathy. Read More

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http://dx.doi.org/10.1210/jc.2019-00453DOI Listing

Early intensive treatment to prevent kidney failure in post-traumatic rhabdomyolysis: Case report.

SAGE Open Med Case Rep 2019 3;7:2050313X19839529. Epub 2019 Apr 3.

Department of Intensive Care, "Pugliese-Ciaccio" General Hospital, Catanzaro, Italy.

Traumatic rhabdomyolysis is a clinical and biological syndrome secondary to lysis of striated muscle fibers resulting in extended musculoskeletal damage. An acute muscle damage causes the release of constituent elements of the sarcoplasmic reticulum, such as muscle enzymes, potassium, and myoglobin in plasma circulation; these conditions are at great risk of dangerous systemic complications for life such as hypovolemic shock, hyperkalemia, and acute kidney injury. We describe the case of a patient who suffered a severe musculoskeletal and vascular trauma with elevated creatine kinase values and myoglobinemia treated early with coupled plasma filtration adsorption in order to prevent kidney damage, associated with volume replacement, loop diuretics, and correction of metabolic acidosis. Read More

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http://dx.doi.org/10.1177/2050313X19839529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448103PMC
April 2019
1 Read

[Carnitin-Palmitoyl Transferase type 2 deficiency: a rare cause of acute renal failure due to rhabdomyolysis].

G Ital Nefrol 2019 Apr;36(2)

UOSVD di Nefrologia e Dialisi ASL Bari. Sede Direzionale: Osp. "S. Maria degli Angeli" Putignano.

Fatty acid oxidation disorders are inborn errors of metabolism. One of the possible alterations involves the failure of the carnitin-based transport of long-chain fatty acids into the mitochondria, necessary for muscle metabolism in case of prolonged physical exertion. Three kinds of Carnitin-Palmitoyl Transferase type 2 (CPT2) deficiency have been described: a myopathic form, a severe infantile form and a neonatal form. Read More

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April 2019
1 Read

Parkinsonism in PGK1 deficiency implicates the glycolytic pathway in nigrostriatal dysfunction.

Parkinsonism Relat Disord 2019 Apr 5. Epub 2019 Apr 5.

Movement Disorders Unit, Neurology Department, Westmead Hospital, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, Australia. Electronic address:

Background: Phosphoglycerate kinase-1 deficiency is caused by X-linked recessive mutations in PGK-1 and associated with haemolytic anaemia, rhabdomyolysis, myopathy and nervous system involvement. Some cases have been rarely associated with juvenile Parkinsonism however the causal relationship between PGK1 deficiency and nigrostriatal dysfunction causing Parkinsonism has not been determined.

Objective And Methods: To investigate the nigrostriatal system using 99mTc-TRODAT-1 SPECT binding and report the phenotype of three affected males with early onset levodopa responsive Parkinsonism harbouring the c. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.04.004DOI Listing
April 2019
4 Reads

Diacerein protects against glycerol-induced acute kidney injury: Modulating oxidative stress, inflammation, apoptosis and necroptosis.

Chem Biol Interact 2019 Apr 8;306:47-53. Epub 2019 Apr 8.

Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Necroptosis is suggested to have an important role in the pathogenesis of rhabdomyolysis induced acute kidney injury (AKI). In this study, the renoprotective effect of diacerein on glycerol-induced AKI was investigated. Twenty four male albino rats were included in this study and divided into four groups: (group I) saline control group, (group II) glycerol-treated group, (groups III&IV) diacerein + glycerol -treated groups (25 and 50 mg/kg/day) respectively. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.008DOI Listing
April 2019
4 Reads

Rhabdomyolysis and Malaria in a College Football Player.

Curr Sports Med Rep 2019 Apr;18(4):112-114

Davidson College Sports Medicine, Davidson, NC.

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http://dx.doi.org/10.1249/JSR.0000000000000579DOI Listing

Major increase in creatine kinase after intensive exercise.

Tidsskr Nor Laegeforen 2019 Apr 8;139(7). Epub 2019 Apr 8.

Background: Exercise-induced rhabdomyolysis is an increasingly frequent cause of hospitalisation and is much debated in the media. The real incidence of the condition is unknown. We wanted to investigate changes in creatine kinase (CK) levels in healthy students following intensive exercise and to look for a correlation between CK, pain and previous exercise history. Read More

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http://dx.doi.org/10.4045/tidsskr.18.0120DOI Listing

A rare iatrogenic association of syndrome of inappropriate secretion of antidiuretic hormone, neuroleptic malignant syndrome and rhabdomyolysis.

Oxf Med Case Reports 2019 Mar 29;2019(3):omz010. Epub 2019 Mar 29.

1U.O.C di Medicina Generale e Lungodegenza.

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is considered the prevalent cause of hyponatremia in hospitalized patients. Neuroleptic malign syndrome (NMS) is an idiosyncratic drug reaction showing fever, dysautonomia and rigidity with increased levels of Creatinine-phosphokinase (CPK) dependent on leakage of muscle contents into the circulation and defined as rhabdomyolysis. Although different diagnostic criteria for NMS have been established, it should be recognized that atypical presentations occur, particularly during treatment with atypical antipsychotics. Read More

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http://dx.doi.org/10.1093/omcr/omz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440259PMC
March 2019
2 Reads

High-Prevalence Vitamin D Deficiency among Korean Emergency Department Homeless, with a Comparison to a Healthy Korean Population.

Nutrients 2019 Apr 1;11(4). Epub 2019 Apr 1.

Department of Emergency Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea.

Although nutritional problems are a major concern for the homeless, their vitamin D status has not yet been widely evaluated. This study was a retrospective chart review conducted at a single academic, urban public hospital's emergency department (ED). Patients whose serum 25-hydroxyvitamin D [25(OH)D] levels had been checked in the ED from July 2014 to June 2015 were reviewed and enrolled. Read More

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http://dx.doi.org/10.3390/nu11040763DOI Listing
April 2019
1 Read

Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI.

Case Rep Med 2019 26;2019:2601537. Epub 2019 Feb 26.

Division of Pulmonary and Critical Care, Pikeville Medical Center, Pikeville, KY, USA.

We report a case of rhabdomyolysis and severe acute kidney injury (AKI) requiring dialysis in a 69-year-old male who was recently started on sitagliptin while on chronic simvastatin therapy. This potential interaction is not included in the package insert for sitagliptin. A comprehensive literature review revealed six previous reports of rhabdomyolysis due to drug interaction between sitagliptin and statins including simvastatin, lovastatin, and atorvastatin. Read More

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http://dx.doi.org/10.1155/2019/2601537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413355PMC
February 2019
4 Reads

A voltage-based analysis of fluid delivery and outcomes in burn patients with electrical injuries over a 6-year period.

Burns 2019 Mar 29. Epub 2019 Mar 29.

Eskenazi Health, Department of Pharmacy, 720 Eskenazi Avenue, Indianapolis, IN, 46202, United States. Electronic address:

Introduction: Electrical injuries are associated with significant morbidity for affected patients. While cardiac and surgical interventions have been extensively reported, no practice guidelines or studies have specifically addressed fluid delivery and associated outcomes of patients with electrical injuries. The study objective was to evaluate the differences in fluid delivery in patients with high (≥1000V) and low (<1000V) voltage electrical injuries. Read More

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http://dx.doi.org/10.1016/j.burns.2018.08.020DOI Listing
March 2019
1 Read

[Clinical analysis of 22 cases of syndrome caused by acute poisoning].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Feb;37(2):136-138

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

To analyze the clinical characteristics, treatment and prognosis of rhabdomyolysis (RM) caused by acute poisoning.Summarize the clinical characteristics and treatment experience, pay attention to the complications and improve the quality of rescue. We collecte and summarize the clinical data, treatment and prognosis of 22 cases of RM caused by acute poisoning. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.02.012DOI Listing
February 2019
1 Read

Rhabdomyolysis and Acute Kidney Injury Associated with Anabolic Steroid Use.

Am J Med 2019 Mar 27. Epub 2019 Mar 27.

Department of Internal Medicine, Mon Health Medical Center, Morgantown, WV. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.02.052DOI Listing
March 2019
2 Reads
5.003 Impact Factor

Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis.

BMC Med 2019 Mar 26;17(1):67. Epub 2019 Mar 26.

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.

Background: Statins may prevent recurrent ischemic events after ischemic stroke. Determining which statin to use remains controversial. We aimed to summarize the evidence for the use of statins in secondary prevention for patients with ischemic stroke by comparing benefits and harms of various statins. Read More

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http://dx.doi.org/10.1186/s12916-019-1298-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436237PMC
March 2019
2 Reads

Rhabdomyolysis - Exercise induced nightmare.

J Family Med Prim Care 2019 Jan;8(1):305-307

Department of Medicine, Tata Main Hospital, Jamshedpur, Jharkhand, India.

The term rhabdomyolysis refers to the disintegration of striated muscle which results in the release of muscular cell constituents into the extracellular fluid and circulation. Exertional rhabdomyolysis is occasionally seen after strenuous exercise. The progression to compartmental syndrome or renal failure is a rare complication that requires prompt recognition and treatment to prevent morbidity. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_370_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396594PMC
January 2019
1 Read

Rhabdomyolysis - Go big or go home.

Am J Emerg Med 2019 Mar 14. Epub 2019 Mar 14.

St Joseph's University Medical Center, Paterson, NJ, United States of America.

Objective: To evaluate the occurrence of renal injury in hospitalized patients with the diagnosis of rhabdomyolysis among a series of patients presenting to an urban emergency department.

Methods: A retrospective chart review between January 2006 and February 2017 was conducted on patients aged 21-65 years old that were admitted with a diagnosis of Rhabdomyolysis. We included patients with an initial serum creatinine (Cr) level < 1. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.03.024DOI Listing

Novel Asp511Thr mutation in McArdle disease with acute kidney injury caused by rhabdomyolysis.

CEN Case Rep 2019 Mar 21. Epub 2019 Mar 21.

Department of Nephrology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 7348551, Japan.

McArdle disease (glycogen storage disease type V) is a rare hereditary metabolic myopathy. It can be overlooked clinically because it often presents as chronic asymptomatic hypercreatine phosphokinasemia (hyperCKemia). However, vigorous exercise or infections can trigger severe rhabdomyolysis. Read More

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http://dx.doi.org/10.1007/s13730-019-00392-6DOI Listing
March 2019
2 Reads

A case of severe rhabdomyolysis associated with secondary adrenal insufficiency and autoimmune hepatitis.

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

General Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Rhabdomyolysis is a serious and life-threatening condition which has many established causes including endocrine disturbances. Of those, thyroid, adrenal and pituitary deficiencies are the most commonly seen. Most cases of rhabdomyolysis with adrenal insufficiency that have been reported have been primary. Read More

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http://dx.doi.org/10.1136/bcr-2018-227343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453326PMC
March 2019
3 Reads

Exertional Rhabdomyolysis in a Long-Distance Migrant.

J Emerg Med 2019 Mar 18. Epub 2019 Mar 18.

Department of Emergency Medicine, Maimonides Medical Center, Brooklyn, New York.

Background: Exertional rhabdomyolysis is a common condition with potentially life-threatening consequences; early recognition can prevent severe downstream complications. Some migrants and undocumented immigrants who have travelled to the United States have encountered extreme heat or other austere conditions during their journey, many of which have involved long stretches of travel on foot. These factors can combine to put these migrants at risk for rhabdomyolysis. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.01.034DOI Listing
March 2019
1 Read

Spectrum of acute kidney injury associated with cocaine use: report of three cases.

BMC Nephrol 2019 Mar 20;20(1):99. Epub 2019 Mar 20.

Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Estadual University of Ceará, Fortaleza, Brazil.

Background: The consequences of cocaine use are multisystemic, such as, for instance, renal failure, hepatotoxicity and pulmonary toxicity, with renal alterations being the focus of the present study. The use of substances that modify the base composition of cocaine (or adulterants) aiming to potentiate its effects also has an impact on these manifestations. The present study aims to report three cases with different diagnosis of acute kidney injury related to cocaine use. Read More

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http://dx.doi.org/10.1186/s12882-019-1279-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427899PMC
March 2019
3 Reads

Epidemiology, toxicokinetics and biomarkers after self-poisoning with Gloriosa superba.

Clin Toxicol (Phila) 2019 Mar 19:1-7. Epub 2019 Mar 19.

a South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine , University of Peradeniya , Peradeniya , Sri Lanka.

Introduction: Gloriosa superba is a flowering plant that contains colchicine. Deliberate self-poisoning with this plant in Sri Lanka is common and potentially fatal. The objective of this study was to describe the epidemiology, toxicokinetics and selected biomarkers in these patients. Read More

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http://dx.doi.org/10.1080/15563650.2019.1581939DOI Listing
March 2019
2 Reads

Phosphoglycerate kinase deficiency: A nationwide multicenter retrospective study.

J Inherit Metab Dis 2019 Mar 19. Epub 2019 Mar 19.

Neurology Department, Hôpital Raymond Poincaré, Paris, France.

Phosphoglycerate kinase (PGK) deficiency is a rare X-linked metabolic disorder caused by mutations in the PGK1 gene. Patients usually develop various combinations of nonspherocytic hemolytic anemia (NSHA), myopathy, and central nervous system disorders. In this national multicenter observational retrospective study, we recorded all known French patients with PGK deficiency, and 3 unrelated patients were identified. Read More

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http://dx.doi.org/10.1002/jimd.12087DOI Listing
March 2019
1 Read

Higher Body Mass Index and Black Race Increase Risk of Rhabdomyolysis and Acute Kidney Injury After Trauma.

J Invest Surg 2019 Mar 19:1-2. Epub 2019 Mar 19.

a Department of Surgery , Morristown Medical Center , Morristown , NJ , USA.

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http://dx.doi.org/10.1080/08941939.2018.1502378DOI Listing
March 2019
1 Read

Wasp venom and acute kidney injury: The mechanisms and therapeutic role of renal replacement therapy.

Toxicon 2019 May 14;163:1-7. Epub 2019 Mar 14.

Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441000, Hubei, China. Electronic address:

Stinging accidents involving wasp venom are a notable cause of acute kidney injury (AKI) in Asia. However, very little attention has been paid to the understanding of the mechanisms involved in this type of AKI. The aims of this review are to explore the evidence for the mechanisms and the therapeutic role of renal replacement therapy of wasp venom and AKI. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.03.008DOI Listing
May 2019
2 Reads

Mechanisms of statin-associated skeletal muscle-associated symptoms.

Pharmacol Res 2019 Mar 12. Epub 2019 Mar 12.

Division of Clinical Pharmacolog 2415 y & Toxicology, University Hospital, 4031, Basel, Switzerland; Department of Biomedicine, University of Basel, Switzerland; Swiss Centre for Applied Human Toxicology (SCAHT), Basel, Switzerland. Electronic address:

Statins lower the serum low-density lipoprotein cholesterol and prevent cardiovascular events by inhibiting 3-hydroxy-3-methyl-glutaryl-CoA reductase. Although the safety of statins is documented, many patients ingesting statins may suffer from skeletal muscle-associated symptoms (SAMS). Importantly, SAMS are a common reason for stopping the treatment with statins. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.010DOI Listing
March 2019
4 Reads

A Vavraia-like microsporidium as the cause of deadly infection in threatened and endangered Eurycea salamanders in the United States.

Parasit Vectors 2019 Mar 14;12(1):108. Epub 2019 Mar 14.

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

Background: Eurycea sosorum (Barton Springs salamander) and Eurycea nana (San Macros salamander) are listed as endangered and threatened species, respectively, by the U.S. Fish and Wildlife Service (USFWS) with habitats restricted to small regions near Austin, Texas, USA. Read More

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http://dx.doi.org/10.1186/s13071-019-3369-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419446PMC
March 2019
1 Read

Muscle Damage, Soreness, and Stress During Preseason Training in Collegiate Swimmers.

Clin J Sport Med 2019 Mar 1. Epub 2019 Mar 1.

Exercise Science Program, Oakland University, Rochester, Michigan.

Background: In 2014, 6 collegiate swimmers were hospitalized for symptomatic exertional rhabdomyolysis.

Objective: To serially monitor and assess relationships between skeletal muscle membrane disruption, upper body soreness (UBS) and lower body soreness (LBS), and stress during the first 6 weeks (timepoints) of preseason training in collegiate male and female swimmers.

Design: Prospective observational study. Read More

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http://dx.doi.org/10.1097/JSM.0000000000000736DOI Listing
March 2019
6 Reads

Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review.

Case Rep Nephrol 2019 4;2019:4890287. Epub 2019 Feb 4.

Division of Pulmonary and Critical Care Medicine, Pikeville Medical Center, USA.

Acute hyperuricemia most commonly occurs in patients who experience tumor lysis syndrome. Hyperuricemia along with other electrolyte abnormalities like hyperkalemia, hypocalcemia, and hyperphosphatemia leads to acute kidney injury (AKI) due to acute uric acid nephropathy which is associated with significant morbidity. High risk patients are thus closely monitored for signs of these laboratory abnormalities. Read More

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http://dx.doi.org/10.1155/2019/4890287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378786PMC
February 2019
2 Reads

Radiographic Musculoskeletal Findings Indicating Opioid Misuse: An Overview for Orthopedic Surgeons.

HSS J 2019 Feb 8;15(1):84-92. Epub 2019 Jan 8.

2UHealth Sports Medicine Institute, University of Miami Miller School of Medicine, Coral Gables, FL USA.

Background: Given the high prevalence of musculoskeletal conditions in the USA, it is important for orthopedic surgeons to promptly identify patients who may be at risk for opioid misuse.

Questions/purposes: The aim of this literature review was to elucidate various musculoskeletal pathologies and complications, as seen on imaging, that may indicate opioid misuse or opioid use disorder.

Methods: A literature search was conducted using the PubMed, Scopus, and Cochrane Library databases for articles related to imaging findings associated with chronic opioid use or misuse in orthopedic patients. Read More

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http://dx.doi.org/10.1007/s11420-018-09654-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384203PMC
February 2019
2 Reads

Propofol infusion syndrome: a structured literature review and analysis of published case reports.

Br J Anaesth 2019 Apr 6;122(4):448-459. Epub 2019 Feb 6.

Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Department of Anaesthesia, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address:

Propofol infusion syndrome is a rare, potentially fatal condition first described in children in the 1990s and later reported in adults. We provide a narrative review of what is currently known about propofol infusion syndrome, including a structured analysis of all published case reports; child and adult cases were analysed separately as propofol is no longer used for long-term sedation in children. The review contains an update on current knowledge of the pathophysiology of this condition along with recommendations for its diagnosis, prevention, and management. Read More

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http://dx.doi.org/10.1016/j.bja.2018.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435842PMC
April 2019
7 Reads

Reflections on Rhabdomyolysis: Litigations and Considerations.

Authors:
E Randy Eichner

Curr Sports Med Rep 2019 Mar;18(3):63-64

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http://dx.doi.org/10.1249/JSR.0000000000000574DOI Listing

Establishment and characterization of a mouse model of rhabdomyolysis by coadministration of statin and fibrate.

Toxicol Lett 2019 Jun 7;307:49-58. Epub 2019 Mar 7.

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address:

Rhabdomyolysis is characterized by elevation of plasma creatine phosphokinase (CPK) level, and multiple organ disorders, especially renal failure, as well as approximately 50% of acquired rhabdomyolysis are caused by pharmaceuticals. Statins are known to cause rhabdomyolysis, and its incidence is ≥10 times higher with coadministration of statin and fibrate. The purpose of this study is to establish a mouse model of drug-induced rhabdomyolysis by coadministration of statin and fibrate to clarify the mechanisms of its myotoxicity. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.03.001DOI Listing
June 2019
2 Reads

[Rhabdomyolysis and severe hypercalcemia. Report of one case].

Rev Med Chil 2019 ;147(1):125-129

Departamento de Nefrología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.4067/S0034-98872019000100125DOI Listing
March 2019
6 Reads

Therapeutic hypernatremia management during continuous renal replacement therapy with elevated intracranial pressures and respiratory failure.

Rev Endocr Metab Disord 2019 Mar 8. Epub 2019 Mar 8.

Medicover GmbH, Berlin, Germany.

Cerebral edema and elevated intracranial pressure (ICP) are common complications of acute brain injury. Hypertonic solutions are routinely used in acute brain injury as effective osmotic agents to lower ICP by increasing the extracellular fluid tonicity. Acute kidney injury in a patient with traumatic brain injury and elevated ICP requiring renal replacement therapy represents a significant therapeutic challenge due to an increased risk of cerebral edema associated with intermittent conventional hemodialysis. Read More

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http://dx.doi.org/10.1007/s11154-019-09483-2DOI Listing
March 2019
2 Reads
4.892 Impact Factor

CrossFit and rhabdomyolysis: A case series of 11 patients presenting at a single academic institution.

J Sci Med Sport 2019 Feb 22. Epub 2019 Feb 22.

Department of Neurosurgery, Northwestern Memorial Hospital, Northwestern Medicine, USA.

Objectives: CrossFit is an increasingly popular high intensity work out program geared towards high repetition and intensity done in short intervals. Recently, documented cases of rhabdomyolysis (muscle necrosis and extreme muscle breakdown) after CrossFit participation have become increasingly concerning to physicians and participants alike.

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1016/j.jsams.2019.01.019DOI Listing
February 2019

An unusual ryanodine receptor 1 (RYR1) phenotype: Mild calf-predominant myopathy.

Neurology 2019 Apr 6;92(14):e1600-e1609. Epub 2019 Mar 6.

From the Neuromuscular Research Center (M. Jokela, S.L., J.P., B.U.), Department of Neurology, University Hospital and University of Tampere; Division of Clinical Neurosciences (M. Jokela), Department of Neurology, Turku University Hospital and University of Turku; Kiinamyllynkatu 4-8 (M. Jokela), Turku, Finland; Unità Operativa Complessa di Neurologia (G.T.), Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Folkhälsan Institute of Genetics and Department of Medical Genetics (A.V., P.-H.J., S.V., M. Johari, M.S.), Haartman Institute, University of Helsinki, Finland; Institute of Pediatric Neurology (E.M., M.P.), Catholic University School of Medicine, Rome, Italy; Department of Pathology (S.H.), Fimlab Laboratories, Tampere University Hospital, Finland; Metabolic and Neuromuscular Unit (M.D.), Meyer Hospital, Florence, Italy; Department of Pediatric Neurology (P.I.), Children's Hospital, University of Helsinki and Helsinki University Hospital; Department of Neurology (P.H.), Kuopio University Hospital and University of Eastern Finland; and Department of Neurology (B.U.), Vasa Central Hospital, Finland.

Objective: To identify the genetic defect causing a distal calf myopathy with cores.

Methods: Families with a genetically undetermined calf-predominant myopathy underwent detailed clinical evaluation, including EMG/nerve conduction studies, muscle biopsy, laboratory investigations, and muscle MRI. Next-generation sequencing and targeted Sanger sequencing were used to identify the causative genetic defect in each family. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007246DOI Listing
April 2019
8.286 Impact Factor

Extreme Rhabdomyolysis, Acute Renal Failure, and Protracted Ileus in a Case of Legionella Pneumonia.

Case Rep Crit Care 2019 29;2019:3472627. Epub 2019 Jan 29.

Department of Intensive Care, Centre Hospitalier de Mouscron, 7700 Mouscron, Belgium.

A 53-year-old man developed a pneumonia complicated by rhabdomyolysis, acute kidney injury, and protracted ileus. Risk factors were smoking and chronic alcoholism, but the patient had no history of previous abdominal surgery. Hemodialysis was required for a period of 5 weeks with a full renal recovery. Read More

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http://dx.doi.org/10.1155/2019/3472627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374832PMC
January 2019
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Severe Influenza A(H1N1) Virus Infection Complicated by Myositis, Refractory Rhabdomyolysis, and Compartment Syndrome.

Case Rep Med 2019 30;2019:1540761. Epub 2019 Jan 30.

Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut 06510, USA.

Myositis is a rare and morbid complication of influenza infection that can rapidly progress to rhabdomyolysis with acute renal failure. Here, we describe a 35-year-old obese woman with severe influenza A(H1N1) virus infection complicated by myositis, refractory rhabdomyolysis, and compartment syndrome. Read More

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http://dx.doi.org/10.1155/2019/1540761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374868PMC
January 2019
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Muscle spasm-induced exothermia in dystonic cerebral palsy: uncommon and frequently misdiagnosed condition.

BMJ Case Rep 2019 Mar 4;12(3). Epub 2019 Mar 4.

Department of Medicine, Section of Hypertension, University of the Philippines - Philippine General Hospital, Manila, Philippines.

A known cerebral palsy young man presented with prolonged bouts of generalised body movements associated with high-grade fever without any localising signs of infection, requiring multiple hospital admissions over several months. All septic work-ups, including a lumbar puncture, were negative. Serum chemistry was consistent with rhabdomyolysis. Read More

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http://dx.doi.org/10.1136/bcr-2018-227488DOI Listing
March 2019
5 Reads

Syrian rue seeds interacted with acacia tree bark in an herbal stew resulted in N,N-dimethyltryptamine poisoning.

Clin Toxicol (Phila) 2019 Mar 4:1-3. Epub 2019 Mar 4.

d Department of Emergency Medicine , Chang Gung Memorial Hospital , Keelung , Taiwan.

Introduction: Illicit substance use is an increasing problem all over the world, especially in adolescents and young adults. It is a challenge to make a definitive diagnosis of a specific substance in a poisoning case without toxicology laboratory confirmation. We confirmed the presence of N,N-dimethyltryptamine (DMT) by liquid chromatograph tandem mass spectrometer (LC/MS/MS) in biologic samples from two patients who presented with signs and symptoms consistent with sympathomimetic toxicity following the consumption of an herbal stew. Read More

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http://dx.doi.org/10.1080/15563650.2019.1576877DOI Listing
March 2019
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Illicit drug use and acute kidney injury in patients admitted to hospital with rhabdomyolysis.

Intern Med J 2019 Feb 28. Epub 2019 Feb 28.

Department of General Medicine, Monash Health, Clayton, Victoria, 3168, Australia.

Background: Severe rhabdomyolysis is associated with acute kidney injury but it is unclear if patients developing rhabdomyolysis after illicit drug use have a higher risk of acute kidney injury compared to other causes.

Aims: To provide a descriptive analysis of patients admitted with rhabdomyolysis, with a focus on illicit drug use, and to determine if illicit drug use was an independent predictor for acute kidney injury or renal replacement therapy.

Methods: We conducted a 5-year cohort study of patients admitted to Monash Health, a tertiary referral hospital network. Read More

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http://dx.doi.org/10.1111/imj.14266DOI Listing
February 2019
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A case of West Nile virus encephalitis accompanied by diabetic ketoacidosis and rhabdomyolysis.

IDCases 2019 13;15:e00505. Epub 2019 Feb 13.

Department of Medicine, University of Florida College of Medicine-Jacksonville, Florida, United States.

Introduction: We present here a case of West Nile Virus (WNV) encephalitis that initially presented with diabetic ketoacidosis and rhabdomyolysis.

Case Presentation: A 35-year-old male with no past medical history presented to the emergency department complaining of polydipsia, generalized weakness, lightheadedness, and visual disturbances of one week duration. He was found to be in diabetic ketoacidosis. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378900PMC
February 2019
2 Reads

Clinical Characteristic and Risk Factors of Acute Kidney Injury among Dengue Viral Infections in Adults: A Retrospective Analysis.

Indian J Nephrol 2019 Jan-Feb;29(1):15-21

Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

Dengue is a growing public health problem in India, and acute kidney injury (AKI) is one of the least studied complications of dengue virus infection (DVI). This study was conducted to investigate the incidence, clinical characteristics, and risk factors for AKI in DVI. This was a retrospective study of patients with confirmed DVI presenting as dengue fever (DF) or dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) at our center over a period of 2 years. Read More

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http://dx.doi.org/10.4103/ijn.IJN_437_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375009PMC
March 2019
1 Read

Synthetic Cannabinoid-Associated Multiple Organ Failure: Case Series and Literature Review.

Pharmacotherapy 2019 Apr 27;39(4):508-513. Epub 2019 Mar 27.

Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, Maryland.

Objective: We describe a multicenter descriptive case series of six patients admitted with synthetic cannabinoid (SC) intoxication displaying similar symptoms and sequelae, all resulting in multiple organ failure.

Methods: Patients were included in this report if they presented with known SC use and experienced multiple organ failure between March 1, 2016, and July 19, 2016, to the intensive care units of three hospitals in Maryland. Patients were followed to either discharge or death, and complications related to SC were documented. Read More

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http://doi.wiley.com/10.1002/phar.2241
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http://dx.doi.org/10.1002/phar.2241DOI Listing
April 2019
11 Reads