9,244 results match your criteria Rhabdomyolysis


Clinically significant drug-drug interactions involving medications used for symptom control in patients with advanced malignant disease. A systematic review.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Regional Centre of Excellence for Palliative Care, Western Norway, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine K1, University of Bergen, Bergen, Norway.

Context: Most patients with advanced malignant disease need to take several drugs to control symptoms. This treatment raises risks of serious adverse effects and drug-drug interactions (DDIs).

Objectives: To identify studies reporting clinically significant DDIs involving medications used for symptom control, other than opioids used for pain management, in adult patients with advanced malignant disease. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.006DOI Listing
February 2019

Acute kidney injury model established by systemic glutathione depletion in mice.

J Appl Toxicol 2019 Feb 15. Epub 2019 Feb 15.

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Glutathione (GSH) is one of the most extensively studied tripeptides. The roles for GSH in redox signaling, detoxification of xenobiotics and antioxidant defense have been investigated. A drug-induced rhabdomyolysis mouse model was recently established in L-buthionine-(S,R)-sulfoximine (BSO; a GSH synthesis inhibitor)-treated normal mice by co-administration of antibacterial drug and statin. Read More

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http://doi.wiley.com/10.1002/jat.3780
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http://dx.doi.org/10.1002/jat.3780DOI Listing
February 2019
4 Reads

Consensus Statement of the Malignant Hyperthermia Association of the United States on Unresolved Clinical Questions Concerning the Management of Patients With Malignant Hyperthermia.

Anesth Analg 2019 Feb 12. Epub 2019 Feb 12.

Department of Anesthesia, University of Iowa, Iowa City, Iowa.

At a recent consensus conference, the Malignant Hyperthermia Association of the United States addressed 6 important and unresolved clinical questions concerning the optimal management of patients with malignant hyperthermia (MH) susceptibility or acute MH. They include: (1) How much dantrolene should be available in facilities where volatile agents are not available or administered, and succinylcholine is only stocked on site for emergency purposes? (2) What defines masseter muscle rigidity? What is its relationship to MH, and how should it be managed when it occurs? (3) What is the relationship between MH susceptibility and heat- or exercise-related rhabdomyolysis? (4) What evidence-based interventions should be recommended to alleviate hyperthermia associated with MH? (5) After treatment of acute MH, how much dantrolene should be administered and for how long? What criteria should be used to determine stopping treatment with dantrolene? (6) Can patients with a suspected personal or family history of MH be safely anesthetized before diagnostic testing? This report describes the consensus process and the outcomes for each of the foregoing unanswered clinical questions. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004039DOI Listing
February 2019
3.472 Impact Factor

Can acute stress be fatal? A systematic cross-disciplinary review.

Stress 2019 Feb 15:1-9. Epub 2019 Feb 15.

b Psychiatric Centre Copenhagen, Department O, Rigshospitalet , Copenhagen University Hospital ,  Copenhagen , Denmark.

In this review it is discussed if acute stress can be fatal. The review is based on literature searches on PubMed, PsycINFO as well as Web of Science. Literature concerning the conditions excited delirium syndrome (ExDS), malignant catatonia, takotsubo cardiomyopathy (TCM), and capture myopathy (CM) is reviewed and compared. Read More

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https://www.tandfonline.com/doi/full/10.1080/10253890.2018.1
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http://dx.doi.org/10.1080/10253890.2018.1561847DOI Listing
February 2019
3 Reads

Acute Exertional Upper-Extremity Rhabdomyolysis as a Result of a Single Training Event: Report of 3 Female Trainees.

Authors:
Bruce A Cohen

Fed Pract 2018 Apr;35(4):34-37

is a Medical Officer for the Department of Justice at the Federal Bureau of Investigation. He also is a retired Captain of the US Navy Medical Corps.

Early diagnosis and comprehensive management of exertional rhabdomyolysis are crucial to ensure full recovery and avoidance of complications. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368050PMC

The hot patient: acute drug-induced hyperthermia.

Aust Prescr 2019 Feb 1;42(1):24-28. Epub 2019 Feb 1.

Royal Prince Alfred Hospital, Sydney.

Drugs Can Cause Dysregulation Of The Hypothalamic–pituitary–adrenal Axis Which Can Result In A Rise In Core Temperature This Type Of Hyperthermia Is Unresponsive To Antipyretics And Can Be Complicated By Rhabdomyolysis Multi-organ Failure And Disseminated Intravascular Coagulation:

Organic Causes Of Fever Such As Infection Must Be Ruled Out Syndromes Associated With Drug-induced Fever Include Neuroleptic Malignant Syndrome And Anticholinergic Sympathomimetic And Serotonin Toxicity:

The Class Of Offending Drugs As Well As The Temporal Relationship To Starting Or Stopping Them Assists In Differentiating Between Neuroleptic Malignant Syndrome And Serotonin Toxicity:

Immediate Inpatient Management Is Needed The Mainstay Of Management Is Stopping The Drug And Supportive Care Often In The Intensive Care Unit: Read More

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https://www.nps.org.au/australian-prescriber/articles/the-ho
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http://dx.doi.org/10.18773/austprescr.2019.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370613PMC
February 2019
1 Read

Metabolic Acidosis Due To Pyroglutamic Acid.

Eur J Case Rep Intern Med 2018 24;5(10):000949. Epub 2018 Oct 24.

Internal Medicine Department, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

Metabolic acidosis is a common clinical disturbance due to increased plasma acidity caused by a primary decrease in serum HCO3- concentration. It is classified as normal or high anion gap metabolic acidosis. High anion gap metabolic acidosis can result from either a decrease in unmeasured cations (K, Ca2, Mg2) or an increase in unmeasured anions (PO, albumin). Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/949
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http://dx.doi.org/10.12890/2018_000949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346886PMC
October 2018
1 Read

[Severe course of influenza B complicated by rhabdomyolysis and acute respiratory failure resulting in death].

Klin Mikrobiol Infekc Lek 2018 Dec;24(4):118-120

Department of Infectious Diseases, Faculty Hospital Ostrava, Czech Republic, e-mail:

Influenza is an acute viral disease that causes influenza A, B, C. Clinically, flu is typically characterized by fever and respiratory symptoms, sometimes with the need for mechanical ventilation, less frequently by gastrointestinal symptoms and muscle problems; severe are cases with central nervous system involvement. The most common complication of influenza is secondary bacterial infection, typically pneumonia, which is most frequently caused by pneumococci and staphylococci. Read More

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December 2018
1 Read

Acute Manifestations of Neuromuscular Disease.

Semin Neurol 2019 Feb 11;39(1):115-124. Epub 2019 Feb 11.

Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Neuromuscular emergencies may be defined as disorders or exacerbation of diseases of the peripheral nervous system that are rapidly progressive and potentially life-threatening. Such disorders can affect any level of the peripheral nervous system, from the muscle to the anterior horn cell. While their clinical manifestations may vary, severe morbidity and mortality is most frequently the result of neuromuscular respiratory failure. Read More

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http://dx.doi.org/10.1055/s-0038-1676838DOI Listing
February 2019
1 Read

Results from a 78-week, single-arm, open-label phase 2 study to evaluate UX007 in pediatric and adult patients with severe long-chain fatty acid oxidation disorders (LC-FAOD).

J Inherit Metab Dis 2019 Jan;42(1):169-177

Ultragenyx Pharmaceutical Inc., Novato, California, USA.

Long-chain fatty acid oxidation disorders (LC-FAOD) are rare disorders characterized by acute crises of energy metabolism and severe energy deficiency that may present with cardiomyopathy, hypoglycemia, and/or rhabdomyolysis, which can lead to frequent hospitalizations and early death. An open-label Phase 2 study evaluated the efficacy of UX007, an investigational odd-carbon medium-chain triglyceride, in 29 subjects with severe LC-FAOD. UX007 was administered over 78 weeks at a target dose of 25-35% total daily caloric intake (mean 27. Read More

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http://dx.doi.org/10.1002/jimd.12038DOI Listing
January 2019
1 Read

Glycogen metabolism and glycogen storage disorders.

Ann Transl Med 2018 Dec;6(24):474

Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Glucose is the main energy fuel for the human brain. Maintenance of glucose homeostasis is therefore, crucial to meet cellular energy demands in both - normal physiological states and during stress or increased demands. Glucose is stored as glycogen primarily in the liver and skeletal muscle with a small amount stored in the brain. Read More

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http://dx.doi.org/10.21037/atm.2018.10.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331362PMC
December 2018
1 Read

Fatty acid oxidation disorders.

Ann Transl Med 2018 Dec;6(24):473

Department of Pediatrics and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI, USA.

Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism due to disruption of either mitochondrial β-oxidation or the fatty acid transport using the carnitine transport pathway. The presentation of a FAOD will depend upon the specific disorder, but common elements may be seen, and ultimately require a similar treatment. Initial presentations of the FAODs in the neonatal period with severe symptoms include cardiomyopathy, while during infancy and childhood liver dysfunction and hypoketotic hypoglycemia are common. Read More

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http://dx.doi.org/10.21037/atm.2018.10.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331364PMC
December 2018
1 Read

Synergistic heterozygosities beyond energy-related metabolic pathways as the mechanism of recurrent rhabdomyolysis.

Authors:
P Phowthongkum

Mol Genet Metab Rep 2019 Jun 25;19:100452. Epub 2019 Jan 25.

Division of Medical Genetics, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

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http://dx.doi.org/10.1016/j.ymgmr.2019.100452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355508PMC

Treatment of a high cardiovascular risk patient with McArdle's disease with PCSK9 inhibitors.

Clin Investig Arterioscler 2019 Feb 6. Epub 2019 Feb 6.

Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, IIS Aragón, CIBERCV, Zaragoza, España; Universidad de Zaragoza, Zaragoza, España.

A 60-year-old male with familial combined hyperlipidemia, ischemic heart disease and type 2 diabetes. Since childhood, intolerance to intense exercise. The patient was diagnosed of McArdle's disease after an episode of rhabdomyolysis associated with statins as treatment after a myocardial infarction. Read More

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http://dx.doi.org/10.1016/j.arteri.2018.11.005DOI Listing
February 2019

Statins, myalgia, and rhabdomyolysis.

Authors:
Anne Tournadre

Joint Bone Spine 2019 Feb 5. Epub 2019 Feb 5.

Service de rhumatologie, CHU Clermont-Ferrand, Hôpital G Montpied, 63003 Clermont-Ferrand, France; Unité de Nutrition Humaine, UMR1019 INRA/Université Clermont Auvergne, 63000 Clermont-Ferrand, France. Electronic address:

Statin-associated muscle symptoms (SAMSs) vary considerably in frequency and severity, with a spectrum extending from myalgia with normal creatine kinase (CK) levels or asymptomatic hyperCKemia to potentially life-threatening rhabdomyolysis and necrotizing autoimmune myopathy. Myalgia with CK elevation is the most common presentation. Onset is usually within 1 month after statin initiation or dosage intensification, and the symptoms can be expected to resolve within a few weeks after treatment discontinuation. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.01.018DOI Listing
February 2019

A suspected case of anesthesia-induced rhabdomyolysis in a child undergoing strabismus surgery.

J AAPOS 2019 Feb 5. Epub 2019 Feb 5.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaapos.2019.01.006DOI Listing
February 2019

[Atypical presentation of rhabdomyolysis due to hypokalaemia induced by diuretics abuse: Case report from Sierra Leone.]

Rev Fac Cien Med Univ Nac Cordoba 2018 11 13;75(4):310-313. Epub 2018 Nov 13.

Médecins Sans Frontières.

Rhabdomyolysis results from acute necrosis of skeletal muscle fibres and consequent leakage of muscle constituents into the circulation. Its association with anything different than trauma in the Emergency Room is not that frequent. We present the case of a 47-year-old male, hypertensive, that developed weakness and incapability to walk without help, finding on the blood biochemistry that he had developed a rhabdomyolysis due to hipokalemia after abusing of diuretics. Read More

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http://dx.doi.org/10.31053/1853.0605.v75.n4.20398DOI Listing
November 2018
1 Read

18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism.

Sci Rep 2019 Feb 7;9(1):1587. Epub 2019 Feb 7.

Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Japan.

Licorice-induced pseudoaldosteronism is a common adverse effect in traditional Japanese Kampo medicine, and 3-monoglucuronyl glycyrrhetinic acid (3MGA) was considered as a causative agent of it. Previously, we found 22α-hydroxy-18β-glycyrrhetyl-3-O-sulfate-30-glucuronide (1), one of the metabolites of glycyrrhizin (GL) in the urine of Eisai hyperbilirubinuria rats (EHBRs) treated with glycyrrhetinic acid (GA), and suggested that it is also a possible causative agent of pseudoaldosteronism. The discovery of 1 also suggested that there might be other metabolites of GA as causal candidates. Read More

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http://dx.doi.org/10.1038/s41598-018-38182-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367500PMC
February 2019

Daptomycin dosing in obese patients: analysis of the use of adjusted body weight actual body weight.

Ther Adv Infect Dis 2019 Jan-Dec;6:2049936118820230. Epub 2019 Jan 30.

Department of Pharmacy Practice, Wingate University School of Pharmacy, Hendersonville, NC, USA.

Background: Food and Drug Administration-approved daptomycin dosing uses actual body weight, despite limited dosing information for obese patients. Studies report alterations in daptomycin pharmacokinetics and creatine phosphokinase elevations associated with higher weight-based doses required for obese patients. Limited information regarding clinical outcomes with alternative daptomycin dosing strategies in obesity exists. Read More

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http://dx.doi.org/10.1177/2049936118820230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354309PMC
January 2019

Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder Subsequent to Rhabdomyolysis: A Case Report and Literature Review.

Int J Neurosci 2019 Feb 5:1-4. Epub 2019 Feb 5.

a Department of Neurology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 , China.

Rhabdomyolysis could be caused by various mechanisms including autoimmune reaction. Here we reported a case of 76-year-woman diagnosed with aquaporin-4 (AQP4) IgG positive neuromyelitis optica spectrum disorder (NMOSD) following rhabdomyolysis. After a review of literature, we propose that physical injury of skeletal muscle cells may lead to the production of AQP4 IgG and this AQP4 IgG might further decrease the stability of skeletal muscle cells creating a positive feedback loop. Read More

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http://dx.doi.org/10.1080/00207454.2019.1579718DOI Listing
February 2019

Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis.

J Vet Intern Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota.

Background: Sarcolipin (SLN), myoregulin (MRLN), and dwarf open reading frame (DWORF) are transmembrane regulators of the sarcoplasmic reticulum calcium transporting ATPase (SERCA) that we hypothesized played a role in recurrent exertional rhabdomyolysis (RER).

Objectives: Compare coding sequences of SLN, MRLN, DWORF across species and between RER and control horses. Compare expression of muscle Ca regulatory genes between RER and control horses. Read More

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http://dx.doi.org/10.1111/jvim.15425DOI Listing
February 2019

A case of simvastatin-induced myopathy with SLCO1B1 genetic predisposition and co-ingestion of linagliptin and Stevia rebaudiana.

J Clin Pharm Ther 2019 Feb 3. Epub 2019 Feb 3.

Division of Clinical Pharmacology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

What Is Known And Objective: SLCO1B1 T521>C variant carriers are susceptible to simvastatin-induced myopathy. We report a patient who developed rhabdomyolysis possibly triggered by a drug-drug and/or herb-drug interaction.

Case Description: A 69-year-old man presented with myalgia and weakness progressing to severe rhabdomyolysis. Read More

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http://doi.wiley.com/10.1111/jcpt.12805
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http://dx.doi.org/10.1111/jcpt.12805DOI Listing
February 2019
1 Read

Evidence-Based Clinical Management of Ebola Virus Disease and Epidemic Viral Hemorrhagic Fevers.

Infect Dis Clin North Am 2019 Mar;33(1):247-264

Interdepartmental Division of Critical Care, University of Toronto, 209 Victoria Street, 4th Floor, Room 411, Toronto, Ontario M5B 1T8, Canada; Department of Medicine, Université de Sherbrooke, 300112e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada. Electronic address:

The 2014 to 2016 Ebola virus disease outbreak underscored the threat posed by hemorrhagic fevers. Filoviral outbreaks have been identified since 1967, but data collection has remained sparse, limiting current knowledge of these illnesses. Documentation of objective physical signs and laboratory parameters and appropriate clinical management are connected and interdependent. Read More

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http://dx.doi.org/10.1016/j.idc.2018.10.013DOI Listing

Loganetin protects against rhabdomyolysis-induced acute kidney injury by modulating the Toll-like receptor 4 signaling pathway.

Br J Pharmacol 2019 Jan 31. Epub 2019 Jan 31.

Shandong New Time Pharmaceutical Co., LTD., Lunan Pharmaceutical Group Co., Ltd., Linyi, China.

Background And Purpose: Acute kidney injury (AKI) is a rapid renal dysfunctional disease, for which no effective drugs or therapies are available to improve prognosis. Loganetin is a natural product with unknown bioactivities. Here we identified a new protective effect and mechanism of Loganetin in rhabdomyolysis-induced AKI mice model. Read More

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http://dx.doi.org/10.1111/bph.14595DOI Listing
January 2019
4.842 Impact Factor

Statins in Ophthalmology.

Surv Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

3-Hydroxy-3-methyl-gutaryl coenzyme A (HMG-CoA) reductase inhibitors or 'statins' are a class of lipid lowering drugs with anti-inflammatory, immunomodulatory, and vascular effects. Statins are increasingly being used in the treatment of a variety of medical conditions. We examine the actions of statins on the eye and its associated ophthalmic disorders. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.01.013DOI Listing
January 2019
7 Reads

Hyperemesis gravidarum followed by refeeding syndrome causes electrolyte abnormalities induced rhabdomyolysis and diabetes insipidus.

Endocr J 2019 Jan 29. Epub 2019 Jan 29.

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Although hyperemesis gravidarum (HG), an extreme form of morning sickness, is a common complication during pregnancy, HG associated simultaneous onset of rhabdomyolysis and diabetes insipidus due to electrolyte abnormalities are rare. A 34-year-old woman with severe HG at 17 weeks of gestation complicated with appetite loss, weight reduction by 17 kg, general fatigue, myalgia, weakness and polyuria was identified to have simultaneous hypophosphatemia (1.6 mg/dL) and hypokalemia (2. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0496DOI Listing
January 2019
1 Read

ACUTE KIDNEY INJURY INDUCES DRAMATIC P21 UP-REGULATION VIA A NOVEL, GLUCOCORTICOID- ACTIVATED, P53 INDEPENDENT, PATHWAY.

Am J Physiol Renal Physiol 2019 Jan 30. Epub 2019 Jan 30.

Clinical division, Fred Hutchinson Cancer Research Center.

P21, a cyclin kinase inhibitor, is acutely up-regulated during AKI and exerts cytoprotective effects. A proposed mechanism is oxidant stress- induced activation of p53, the dominant p21 transcription factor. Glycerol-induced rhabdomyolysis induces profound renal oxidant stress. Read More

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http://dx.doi.org/10.1152/ajprenal.00571.2018DOI Listing
January 2019

Inflammatory myopathy with myasthenia gravis: Thymoma association and polymyositis pathology.

Neurol Neuroimmunol Neuroinflamm 2019 Mar 24;6(2):e535. Epub 2018 Dec 24.

Department of Neurology (N.U., K.T., C.I., A.U., A.K., T.T., J.S.), Graduate School of Medicine, University of Tokyo; Division of Neurology (M.K., K.K.), Department of Internal Medicine, National Defense Medical College, Saitama; Division of Neurology (Y. Shiio), Tokyo Teishin Hospital; Department of Neurology (Y. Sakurai), Mitsui Memorial Hospital; Department of Neurology (Y.H.), Teikyo University School of Medicine; and Department of Neurology (K.Y., S.N.-E.), Fukushima Medical University, Japan.

Objective: To provide evidence that idiopathic inflammatory myopathy (IM) with myasthenia gravis (MG) frequently shows thymoma association and polymyositis (PM) pathology and shares clinicopathologic characteristics with IM induced by immune checkpoint inhibitors (ICIs).

Methods: We analyzed the clinicopathologic features of 10 patients with idiopathic IM and MG identified in 970 consecutive patients with biopsy-proven IM.

Results: Seven patients (70%) had thymoma. Read More

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http://dx.doi.org/10.1212/NXI.0000000000000535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340335PMC
March 2019
5 Reads

Hyperbaric Oxygen as an Adjunctive Therapy Postfasciotomy for Unilateral Supraspinatus Rhabdomyolysis and Compartment Syndrome.

Case Rep Orthop 2018 30;2018:5485767. Epub 2018 Dec 30.

Department of Medicine CCS, Monash University, Melbourne, VIC, Australia.

We present a case of severe supraspinatus muscle rhabdomyolysis following overexertion in a young male. Preexisting risk factors included illicit drug use. Even single muscle rhabdomyolysis can cause significant renal failure, and in our case the use of intravenous flushing was used in conjunction with hyperbaric oxygen after muscle compartment fasciotomy to maximize muscle recovery and renal protection in a manual worker (musician). Read More

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https://www.hindawi.com/journals/crior/2018/5485767/
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http://dx.doi.org/10.1155/2018/5485767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332935PMC
December 2018
4 Reads

Evaluation and Management of Acute Compartment Syndrome in the Emergency Department.

J Emerg Med 2019 Jan 23. Epub 2019 Jan 23.

Department of Emergency Medicine, Rush University Medical Center, Chicago, Illinois.

Background: Acute compartment syndrome (ACS) is a time-sensitive surgical emergency caused by increased pressure within a closed compartment. ACS can lead to significant morbidity and mortality if it is not rapidly identified and treated.

Objective: This article provides an evidence-based review of the diagnosis and management of ACS, with focused updates for the emergency clinician. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.12.021DOI Listing
January 2019
5 Reads

Spectrum of rhabdomyolysis in an acute hospital.

Ir J Med Sci 2019 Jan 24. Epub 2019 Jan 24.

Department of Nephrology, Tallaght University Hospital, Dublin 24, Ireland.

Rhabdomyolysis is a state of muscle necrosis with the hallmark being elevated creatine kinase that may cause acute kidney injury with serious consequences. It happens in many clinical settings. We sought to investigate all cases of rhabdomyolysis admitted to an acute hospital in Ireland over one calendar year. Read More

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http://dx.doi.org/10.1007/s11845-019-01968-yDOI Listing
January 2019

Defining the Normal Trends of Serum Creatine Kinase Levels Following Spinal Surgery.

Asian Spine J 2019 Jan 24. Epub 2019 Jan 24.

Department of Orthopaedic Surgery, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA, USA.

Study Design: Prospective, prognostic study, level II evidence.

Purpose: To define the normal change in the creatine kinase (CK) levels in patients undergoing prone or supine lumbar or cervical spine surgery and to determine if positioning influences the postoperative changes in the CK levels.

Overview Of Literature: Spine surgery is one of the most commonly performed and fastest growing areas of surgery in the United States. Read More

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http://dx.doi.org/10.31616/asj.2018.0191DOI Listing
January 2019

West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa.

Emerg Infect Dis 2019 Feb;25(2):367-369

West Nile virus (WNV) is an arthropod-transmitted flavivirus that causes West Nile fever and may infrequently cause neuroinvasive disease in humans. We present 2 cases of confirmed WNV infection, 1 of severe encephalitis and 1 of mild febrile illness, in a couple returning to the United Kingdom from South Africa. Read More

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http://dx.doi.org/10.3201/eid2502.172101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346434PMC
February 2019
1 Read

Damage and the repeated bout effect of arm, leg, and trunk muscles induced by eccentric resistance exercises.

Scand J Med Sci Sports 2019 Jan 21. Epub 2019 Jan 21.

Centre for Exercise and Sports Science Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

This study compared nine resistance eccentric exercises targeting arm, leg, and trunk muscles in one session for changes in maximal voluntary isometric contraction strength (MVC), delayed onset muscle soreness (DOMS), plasma creatine kinase (CK) activity, and myoglobin (Mb) concentration after the first and second bouts. Fifteen sedentary men (20-25 years) performed 5 sets of 10 eccentric contractions with 80% of MVC load for the elbow flexors (EF), elbow extensors (EE), pectoralis, knee extensors (KE), knee flexors (KF), plantar flexors (PF), latissimus, abdominis, and erector spinae (ES) in a randomized order and repeated the same exercises 2 weeks later. MVC decreased at 1 (16%-57%) to 4 (13%-49%) days, DOMS developed (peak: 43-70 mm), and CK activity (peak: 23 238-207 304 IU/L) and Mb concentration showed large increases after the first bout. Read More

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http://dx.doi.org/10.1111/sms.13388DOI Listing
January 2019

A case-crossover-based screening approach to identifying clinically relevant drug-drug interactions in electronic healthcare data.

Clin Pharmacol Ther 2019 Jan 21. Epub 2019 Jan 21.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

We sought to develop a semi-automated screening approach using electronic healthcare data to identify drug-drug interactions (DDIs) that result in clinical outcomes. Using a case-crossover design with 30-day hazard and referent windows, we evaluated co-dispensed drugs (potential precipitants) in 7,801 patients who experienced rhabdomyolysis while on CYP3A4-metabolized statins and in 15,147 who experienced bleeding on dabigatran. Estimates of direct associations between precipitant drugs and outcomes were used to adjust for bias and precipitants' direct effects. Read More

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http://doi.wiley.com/10.1002/cpt.1376
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http://dx.doi.org/10.1002/cpt.1376DOI Listing
January 2019
3 Reads

The possible harms of statins: What do product labels, patient package inserts, and pharmacy leaflets tell us?

J Am Pharm Assoc (2003) 2019 Jan 17. Epub 2019 Jan 17.

Objectives: To evaluate the degree to which health care professionals and patients receive consistent messages regarding the possible harms of statins.

Design: Cross-sectional study of prescribing information (PI), patient package inserts (PPIs), and pharmacy leaflets for 8 statins approved by the U.S. Read More

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http://dx.doi.org/10.1016/j.japh.2018.12.003DOI Listing
January 2019

Homozygous TANGO2 Single Nucleotide Variants Presenting with Additional Manifestations Resembling Alternating Hemiplegia of Childhood-Expanding the Phenotype of a Recently Reported Condition.

Neuropediatrics 2019 Jan 16. Epub 2019 Jan 16.

Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, United States.

Case:  We report a 15-year-old Indian girl born to a consanguineous couple, who presented with epilepsy, developmental delay, neuroregression, and episodes of alternating hemiparesis. In addition, she had one episode of rhabdomyolysis at the age of 7 years. Extensive genetic and metabolic work up through the years was unrevealing. Read More

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http://dx.doi.org/10.1055/s-0038-1677514DOI Listing
January 2019

The unusual suspects: a curious case of acute kidney injury-Questions.

Pediatr Nephrol 2019 Jan 16. Epub 2019 Jan 16.

Seattle Children's Hospital, Division of Nephrology, University of Washington, 4800 Sand Point Way, Seattle, WA, 98105, USA.

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http://dx.doi.org/10.1007/s00467-018-4156-3DOI Listing
January 2019
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Prevention of rhabdomyolysis-induced acute kidney injury - A DASAIM/DSIT clinical practice guideline.

Acta Anaesthesiol Scand 2019 Jan 15. Epub 2019 Jan 15.

Department of Intensive Care 4131, Copenhagen University Hospital, Rigshospitalet, Denmark.

Background: Rhabdomyolysis-induced acute kidney injury (AKI) is a common and serious condition. We aimed to summarise the available evidence on this topic and provide recommendations according to current standards for trustworthy guidelines.

Methods: This guideline was developed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Read More

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http://dx.doi.org/10.1111/aas.13308DOI Listing
January 2019
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The clinical management of neuromuscular disorders in intensive care.

Neuromuscul Disord 2018 Dec 18. Epub 2018 Dec 18.

Neurology Division of Critical Care Neurology, Mayo Clinic, Rochester, MN, USA.

Life-threatening neuromuscular disorders affect a small, but growing group of patients in the intensive care unit who present special management problems, as well as great therapeutic opportunities. In inflammatory conditions, a cure is often possible, and for chronic, genetic or degenerative conditions, achieving the previous level of function is the target. Neuromuscular experts and intensivists need to cooperate closely to achieve the best possible outcomes. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.12.005DOI Listing
December 2018
1 Read

[A marathon runner with rhabdomyolysis].

Ned Tijdschr Geneeskd 2019 Jan 9;163. Epub 2019 Jan 9.

Erasmus MC, afd. Spoedeisende Hulp, Rotterdam.

Background: Serious complications after running a marathon are relatively rare. We saw a patient at the emergency department (A&E) who developed acute renal failure as a result of rhabdomyolysis after excessive exertion.

Case Description: A 31-year-old, healthy male was referred to the A&E by the GP service two days after running a marathon because of a CK level of 131,900 U/l. Read More

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January 2019
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An evidence-based narrative review of the emergency department evaluation and management of rhabdomyolysis.

Am J Emerg Med 2019 Jan 2. Epub 2019 Jan 2.

Department of Emergency Medicine, Rush University Medical Center, United States.

Background: Rhabdomyolysis is a medical condition caused by muscle breakdown leading to potential renal damage. This can result in significant morbidity and mortality if not rapidly identified and treated.

Objective: This article provides an evidence-based narrative review of the diagnosis and management of rhabdomyolysis, with focused updates for the emergency clinician. Read More

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http://dx.doi.org/10.1016/j.ajem.2018.12.061DOI Listing
January 2019
2 Reads

Mitochondria-Associated Matrix Metalloproteinases 2 and 9 in Acute Renal Pathologies.

Bull Exp Biol Med 2019 Jan 9;166(3):334-338. Epub 2019 Jan 9.

A. N. Belozersky Research Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.

Activities of MMP-2 and MMP-9 in the cytoplasm and mitochondria of kidney cells were evaluated on the models of acute renal pathologies: pyelonephritis, rhabdomyolysis, and ischemia/reperfusion of the kidney. In acute pyelonephritis, a significant increase in the level of MMP-2 and MMP-9 in kidney cells and the appearance of mitochondrial MMP-2 isoform with a lower molecular weight, but still exhibiting proteolytic activity were observed. A direct correlation between the level of MMP-2 and MMP-9 in the kidney and the severity of inflammation in pyelonephritis was revealed. Read More

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http://link.springer.com/10.1007/s10517-019-04345-y
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http://dx.doi.org/10.1007/s10517-019-04345-yDOI Listing
January 2019
8 Reads

Prevalence of the E321G MYH1 variant for immune-mediated myositis and nonexertional rhabdomyolysis in performance subgroups of American Quarter Horses.

J Vet Intern Med 2019 Jan 8. Epub 2019 Jan 8.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California.

Background: Immune-mediated myositis (IMM) in American Quarter Horses (QHs) causes acute muscle atrophy and lymphocytic infiltration of myofibers. Recently, an E321G mutation in a highly conserved region of the myosin heavy chain 1 (MYH1) gene was associated with susceptibility to IMM and nonexertional rhabdomyolysis.

Objectives: To estimate prevalence of the E321G MYH1 variant in the QH breed and performance subgroups. Read More

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http://doi.wiley.com/10.1111/jvim.15393
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http://dx.doi.org/10.1111/jvim.15393DOI Listing
January 2019
10 Reads

Fusidic Acid: A Neglected Risk Factor for Statin-Associated Myopathy.

Clin Med Insights Cardiol 2018 4;12:1179546818815162. Epub 2018 Dec 4.

Uppsala University Hospital and Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Background: Statins are widely used lipid-lowering drugs used for the prevention of cardiovascular disease. Statins are known to cause myopathy, an adverse drug reaction with various clinical features rhabdomyolysis.

Objective: To describe clinical characteristics of statin-treated individuals who experienced myopathy and identify risk factors of statin-associated myopathy. Read More

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http://dx.doi.org/10.1177/1179546818815162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299330PMC
December 2018
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A systematic review on the definition of rhabdomyolysis.

J Neurol 2019 Jan 7. Epub 2019 Jan 7.

Department of Neurology, Friedrich-Baur-Institute, Ludwig-Maximilians-University Munich, Ziemssenstr. 1a, 80336, Munich, Germany.

Background: Rhabdomyolysis (RML) is an interdisciplinary condition due to muscle cell injury followed by the release of cell components into circulation. Etiology of RML has a broad range; a serious complication is acute kidney injury (AKI). Despite its high relevance, there is no established formal definition for RML. Read More

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http://link.springer.com/10.1007/s00415-019-09185-4
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http://dx.doi.org/10.1007/s00415-019-09185-4DOI Listing
January 2019
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[Rhabdomyolysis in patients treated by corticosteroids for acute asthma in intensive care unit].

Rev Med Interne 2019 Jan 4. Epub 2019 Jan 4.

Service de médecine interne, faculté de médecine SMBH, UMR1125, LI2P, université Paris 13, hôpital universitaire Seine-Saint-Denis, AP-HP Sorbonne Paris Cité, 93000 Bobigny, France. Electronic address:

Introduction: Acute muscle involvement is an infrequent complication of corticosteroids, characterized by muscle weakness and a rhabdomyolysis, rapidly regressive after withdrawal of corticosteroids.

Case Report: We report the case of a woman admitted in intensive care unit for acute severe asthma, treated with high doses of methylprednisolone. Serum CPK level raised with a peak at 28,160 UI/L (n<250 UI/L) at day 15, suggesting acute rhabdomyolysis with renal failure. Read More

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http://dx.doi.org/10.1016/j.revmed.2018.12.005DOI Listing
January 2019
2 Reads

Characteristics and associated factors of acute kidney injury among adult dengue patients: A retrospective single-center study.

PLoS One 2019 7;14(1):e0210360. Epub 2019 Jan 7.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Severe dengue cases have been increasingly reported in Thailand, and the under-reporting of acute kidney injury (AKI) in cases of dengue viral infection has become an obstacle in obtaining an accurate description of the true nature and epidemiology of AKI. Because AKI may lead to patient morbidity and mortality, an early diagnosis is important in preventing its onset in dengue patients. This study aimed to determine the prevalence, clinical and laboratory characteristics, and associated factors of AKI among adult dengue patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210360PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322747PMC
January 2019
5 Reads