10,325 results match your criteria Rhabdomyolysis


Carnitine Palmitoyltransferase-II Deficiency: Case Presentation and Review of the Literature.

Rom J Intern Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Rd S, Jacksonville, FL 32224.

Carnitine palmitoyltransferase-II deficiency, an autosomal recessive disorder, is the most common cause of recurrent rhabdomyolysis in adults. Recognition and avoidance of triggers, such as heavy exercise and stress, is key in prevention of further episodes; however, even with preventative measures, many patients will continue to experience periodic symptoms, including rhabdomyolysis. Avoidance of renal failure, correction of electrolyte disturbances and halting further muscle breakdown are the goals of treatment. Read More

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Acute Gluteal Compartment Syndrome with Nonclassical Symptoms: A Case Report on an Easily Missed Diagnosis.

JBJS Case Connect 2021 Jun 11;11(2). Epub 2021 Jun 11.

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois.

Case: A 34-year-old man presented to the emergency department with rhabdomyolysis, acute kidney injury, and pain in the gluteal region after falling asleep on his side after heroin and alcohol use. On examination, he had swollen gluteal compartment musculature; however, he tolerated full passive range of motion with minimal pain. Intercompartmental pressure measured >110 mm Hg; therefore, emergent fasciotomy of the gluteal compartment musculature was performed. Read More

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Effect of SLCO1B1 T521C on Statin-related Myotoxicity with Use of Lovastatin and Atorvastatin.

Clin Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Pharmacy, University of California San Francisco, San Francisco, California, USA.

The association between the c.521T>C variant allele in SLCO1B1 (rs4149056) and simvastatin-induced myotoxicity was discovered over a decade ago; however, whether this relationship represents a class effect is still not fully known. The aim of this study was to investigate the relationship between rs4149056 genotype and statin-induced myotoxicity in patients taking atorvastatin and lovastatin. Read More

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[Blood purification therapy in two cases of alcoholic liver disease combined with rhabdomyolysis and acute renal failure].

Zhonghua Gan Zang Bing Za Zhi 2021 May;29(5):472-473

Department of Infectious Disease, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

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Successful diagnosis and treatment of pulmonary aspergillosis-related malignant catatonia using propofol and quetiapine: A case report.

Medicine (Baltimore) 2021 May;100(19):e25967

Department of Emergency Medicine, Sapporo Medical University Hospital, Sapporo-shi.

Introduction: Malignant catatonia (MC) is a movement disorder syndrome characterized by immobility, rigidity, and consciousness disorders that develops in association with mental and physical diseases. It is often fatal due to hyperthermia, rhabdomyolysis, and acute kidney injury. Its clinical symptoms are similar to those of another disorder, neuroleptic malignant syndrome (NMS), and it is often difficult to distinguish between the 2 disorders. Read More

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A Case Report of Recurrent Hypokalemia During Pregnancies Associated With Nonaldosterone-Mediated Renal Potassium Loss.

Can J Kidney Health Dis 2021 28;8:20543581211017424. Epub 2021 May 28.

Medical University of South Carolina, College of Medicine, Charleston, SC, USA.

Rationale: Geller et al reported a rare mutation in the mineralocorticoid receptor (MR) resulting in constitutive MR activity. Progesterone, normally an MR antagonist, acts as a potent agonist with this mutation. Progesterone levels can increase 100-fold during pregnancy and thus lead to increased MR activity in this setting, resulting in hypertension (HTN) and hypokalemia during pregnancy and resolution of hypokalemia after delivery. Read More

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Streptococcal Pharyngitis: Delving Deeper than the Throat.

J Coll Physicians Surg Pak 2021 Jun;30(6):732-734

Department of Emergency Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Acute rhabdomyolysis and elevated transaminases during streptococcal pharyngitis are rare presentations. The proposed pathophysiological mechanisms include direct bacterial invasion and toxin generation. Physicians should be aware of the association between these infections and the above-mentioned complications to facilitate optimal treatment of these patients. Read More

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Rhabdomyolysis following an intensive indoor cycling exercise: A series of 5 cases.

Ann Acad Med Singap 2021 05;50(5):431-433

Accident and Emergency Department, Changi General Hospital, Singapore.

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Ibrutinib does not prevent kidney fibrosis following acute and chronic injury.

Sci Rep 2021 Jun 7;11(1):11985. Epub 2021 Jun 7.

UMR 1297, Institut Des Maladies Métaboliques Et Cardiovasculaires, Institut National de La Santé Et de La Recherche Médicale (INSERM), Toulouse, France.

Recent studies suggested that ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, developed for the treatment of chronic lymphocytic leukemia, may prevent NLRP3 inflammasome activation in macrophages, IL-1β secretion and subsequent development of inflammation and organ fibrosis. The role of NLRP3 has been underlined in the various causes of acute kidney injury (AKI), a pathology characterized by high morbimortality and risk of transition toward chronic kidney disease (CKD). We therefore hypothesized that the BTK-inhibitor ibrutinib could be a candidate drug for AKI treatment. Read More

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CrossFit-Induced Rhabdomyolysis in a Young Healthy Indonesian Male.

Cureus 2021 Apr 27;13(4):e14723. Epub 2021 Apr 27.

Department of Internal Medicine, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia/Atma Jaya Hospital, Jakarta, IDN.

CrossFit, a high-intensity interval training, keeps growing in trend and is one of the most favorable types of fitness, after wearable technology. However, an excessive workout is detrimental to the human body, particularly the muscle tissue. CrossFit is known to cause exercise-induced rhabdomyolysis, a concerning disease with potentially devastating consequences. Read More

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Atypical myopathy in 2 Bactrian camels.

J Vet Diagn Invest 2021 Jun 7:10406387211020721. Epub 2021 Jun 7.

Institutes for Veterinary-Pathology, Justus-Liebig-University, Giessen, Germany.

Atypical myopathy (AM) is an acute seasonal rhabdomyolysis seen primarily in equids, caused by the ingestion of sycamore maple samaras containing hypoglycin A (HGA) and methylenecyclopropyl-glycine (MCPG). Toxic metabolites inhibit acyl-CoA dehydrogenases and enoyl-CoA hydratases, causing selective hyaline degeneration of type I muscle fibers. Two zoo-kept Bactrian camels () with a fatal course of AM had sudden onset of muscle pain and weakness, recumbency, and dysphagia, accompanied by increased serum creatine kinase activity and detection in serum of HGA, MCPG, and metabolites. Read More

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Haemiballism/haemichorea: an atypical presentation of ischaemic stroke.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Department of Neurology, Duke University Health System, Durham, North Carolina, USA.

A 76-year-old man was admitted to the hospital with acute onset of involuntary movements of the left side of his body. His neurological examination revealed he was oriented only to himself, and aforementioned movements of his left arm and leg. CT head demonstrated old infarcts in his right aspect of his pons and basal ganglia. Read More

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Rhabdomyolysis After Total Abdominal Hysterectomy Requiring Urgent Hemodialysis Due to Hyperkalemia.

Cureus 2021 Apr 29;13(4):e14757. Epub 2021 Apr 29.

Nephrology, Creighton University School of Medicine, Omaha, USA.

A 63-year-old woman with a past medical history of invasive ductal carcinoma of the breast, status post lumpectomy and chemoradiation, 15 cm left inguinal-femoral enlarged lymph node consistent with high-grade serous carcinoma of the ovary and 4.7 cm right adnexal mass underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and lymph node dissection with cystoscopy and bilateral ureteral catheter placement. There was no intraoperative complication. Read More

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Ameliorative Role of Diallyl Disulfide Against Glycerol-induced Nephrotoxicity in Rats.

J Pharm Bioallied Sci 2021 Jan-Mar;13(1):129-135. Epub 2020 Dec 21.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Introduction: This study investigated the role of diallyl disulfide (DADS) against glycerol-induced nephrotoxicity in rats. Moreover, the role of peroxisome proliferator activated receptor-γ (PPAR-γ) in DADS-mediated renoprotection has been explored.

Materials And Methods: Male Wistar albino rats were challenged with glycerol (50% w/v, 8 mL/kg intramuscular) to induce nephrotoxicity. Read More

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December 2020

Pain in right buttock after carbon monoxide poisoning.

Authors:
Huijun Hu Qiang Sun

BMJ 2021 06 3;373:n1233. Epub 2021 Jun 3.

Department of Hyperbaric Oxygen, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

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A Rare Case of Progressive Malignant Triton Tumor With Rare Somatic Mutation in Gene.

Anticancer Res 2021 Jun;41(6):3029-3036

Division of Hematology-Oncology, Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, U.S.A.;

Background: Malignant triton tumor (MTT) is a rare subtype of malignant peripheral nerve sheath tumor with additional rhabdomyolysis differentiation that shows rapid progression and poor clinical outcomes.

Case Report: We report the case of an adult male with a metastatic MTT. Despite extensive counseling, the patient initially refused recommended treatment. Read More

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A rare case of posterior reversible encephalopathy syndrome in a patient with severe leptospirosis complicated with rhabdomyolysis and acute kidney injury; a case report.

BMC Infect Dis 2021 Jun 3;21(1):522. Epub 2021 Jun 3.

National Hospital of Sri Lanka, Colombo 08, Sri Lanka.

Background: Leptospirosis is a zoonotic spirochetal disease caused by Leptospira interrogans. The clinical presentation ranges from an asymptomatic state to a fatal multiorgan dysfunction. Neurological manifestations including aseptic meningitis, spinal cord and peripheral nerve involvement, cranial neuropathies and cerebellar syndrome are well recognized with varying frequencies among patients with this disease. Read More

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Hair-Dye-Related Accidental Poisoning and Death.

Cureus 2021 Apr 21;13(4):e14607. Epub 2021 Apr 21.

Pulmonary and Critical Care Medicine, Veterans Affairs Medical Center, Washington, USA.

Para phenylenediamine (PPD) is a common component of hair dye as well as temporary tattoos and is a well-known cause of type 4 hypersensitivity reactions from topical exposure. While there have been several cases reported in the literature describing toxicities following ingestion, there are a paucity of reports of severe systemic disease following topical exposure. Cases of PPD ingestion have been reported to present with angioedema-like reactions, often progressing to rhabdomyolysis and renal failure. Read More

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Adenovirus Infection and Rhabdomyolysis as a Cause of Acute Liver Failure in a Healthy Collegiate Football Athlete: A Case Report and Proposed Return to Play Protocol for Rhabdomyolysis.

Cureus 2021 Apr 15;13(4):e14510. Epub 2021 Apr 15.

Orthopaedic Surgery, Stanford University, Stanford, USA.

Adenovirus is a common cause of upper respiratory and gastrointestinal tract infections. Though cases of significant organ failure and death have been reported in young children and immunocompromised individuals, adenovirus infections in healthy individuals are typically self-limiting without significant morbidity or mortality. Exertional rhabdomyolysis is a pathologic condition resulting from repetitive, excessive, or prolonged exercise, often in a hot environment, leading to acute muscle injury, renal injury and, rarely, death. Read More

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Incidence of Refeeding Syndrome in Pediatric Inpatients at the US-Mexico Border.

South Med J 2021 Jun;114(6):351-355

From the Paul L. Foster School of Medicine, Texas Tech University Health Science Center at El Paso, El Paso.

Objectives: Refeeding syndrome is a life-threatening, physiological process that occurs when patients with severe malnutrition are too rapidly rehabilitated, leading to the development of electrolyte abnormalities. Hypophosphatemia, a hallmark of the disease, has most commonly been studied, because it is recognized to result in cardiac arrhythmias, seizures, cardiac failure, respiratory failure, rhabdomyolysis, coma, and even death. Although many studies have found caloric intake to be a main causal factor in refeeding syndrome, few have explored other factors, such as geographic location. Read More

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A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome.

Medicina (Kaunas) 2021 May 5;57(5). Epub 2021 May 5.

Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, 08410 Vilnius, Lithuania.

We present a case of tularemia complicated by rhabdomyolysis in a 43-year-old male who presented with fever, swelling, and pain of the right groin and a history of a week-old tick bite. Empirical parenteral amoxicillin/clavulanic acid treatment was initiated. Suspecting tularemia, parenteral gentamycin was added. Read More

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Epidemiology and the Impact of Acute Kidney Injury on Outcomes in Patients with Rhabdomyolysis.

J Clin Med 2021 May 1;10(9). Epub 2021 May 1.

Mercy Internal Medicine Service, Trinity Health of New England, 271 Carew St, Springfield, MA 01104, USA.

Background: Currently, no large, nationwide studies have been conducted to analyze the demographic factors, underlying comorbidities, clinical outcomes, and health care utilization in rhabdomyolysis patients with and without acute kidney injury (AKI).

Methods: We queried the National Inpatient Sample of Healthcare Cost and Utilization Project (HCUP) with patients with rhabdomyolysis from 2016 to 2018. The chi-squared test was used to compare categorical variables, and the adjusted Wald test was employed to compare quantitative variables. Read More

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Guidelines for the acute care of severe limb trauma patients.

Anaesth Crit Care Pain Med 2021 May 28:100862. Epub 2021 May 28.

Soins Intensifs, Hôpitaux Universitaires de Genève, Genève, Suisse.

Goal: To provide healthcare professionals with comprehensive multidisciplinary expert recommendations for the acute care of severe limb trauma patients, both during the prehospital phase and after admission to a Trauma Centre.

Design: A consensus committee of 21 experts was formed. A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. Read More

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A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results.

J Bras Nefrol 2021 May 28. Epub 2021 May 28.

Pontifícia Universidade Católica de São Paulo, Faculdade de Ciências Médicas e da Saúde, São Paulo, SP, Brasil.

Acute kidney injury (AKI) in hospitalized patients with COVID-19 is associated with higher mortality and a worse prognosis. Nevertheless, most patients with COVID-19 have mild symptoms, and about 5% can develop more severe symptoms and involve hypovolemia and multiple organ dysfunction syndrome. In a pathophysiological perspective, severe SARS-CoV-2 infection is characterized by numerous dependent pathways triggered by hypercytokinemia, especially IL-6 and TNF-alpha, leading to systemic inflammation, hypercoagulability, and multiple organ dysfunction. Read More

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Severe rhabdomyolysis and acute kidney failure due to synthetic opioid brorphine exposure in combination with chronic sertraline therapy.

Eur J Clin Pharmacol 2021 May 30. Epub 2021 May 30.

Centre for Clinical Toxicology and Pharmacology, University Medical Centre Ljubljana, Zaloška cesta 7, 1000, Ljubljana, Slovenia.

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Rhabdomyolysis After Consumption of Freshwater Fish (Neolissochilus soroides).

Wilderness Environ Med 2021 May 25. Epub 2021 May 25.

Division of Clinical Toxicology and Occupational Medicine, Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Siriraj Poison Control Center, Siriraj Hospital, Bangkok, Thailand.

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Kounis Syndrome and Multiorgan Failure Following Multiple Wasp Stings.

Cureus 2021 Apr 21;13(4):e14606. Epub 2021 Apr 21.

Forensic Medicine, Teaching Hospital Jaffna, Jaffna, LKA.

Wasp and bee stings are common in Sri Lanka, and systemic envenomation causes a spectrum of clinical manifestations that includes simple local allergic reaction to life-threatening multiple organ injury or failure. However, wasp toxin-induced acute myocardial infarction is very rare in the literature. Here, we describe a pregnant lady with mass wasp stings who developed toxin-induced acute myocardial infarction with multiorgan injury. Read More

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Acute Tramadol Ingestion With Transient Acute Kidney Injury in an Adolescent Female.

J Pediatr Pharmacol Ther 2021 19;26(4):411-413. Epub 2021 May 19.

Renal toxicity has been described with tramadol overdoses; however, it is typically associated with rhabdomyolysis, multiorgan failure and/or mortality. Our patient was a 16-year-old female who was evaluated following an intentional tramadol ingestion, estimated 27.8 to 37 mg/kg, and had a seizure prior to arriving at our health care facility. Read More

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Rhabdomyolysis and severe biphasic disturbance of calcium homeostasis secondary to COVID-19 infection.

BMJ Case Rep 2021 May 24;14(5). Epub 2021 May 24.

Diabetes and Endocrinology, Guy's and St Thomas' Hospitals NHS Trust, London, UK.

We report a case of severe hypercalcaemia secondary to rhabdomyolysis in a woman with COVID-19 (SARS CoV-2) infection. The patient presented with myalgia and anuria with an acute kidney injury requiring haemodialysis. Creatine kinase peaked at 760 000 IU/L. Read More

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