10,864 results match your criteria Rhabdomyolysis


Extraordinary Creatine Phosphokinase Levels in Coxsackie B Necrotizing Myopathy Complicated by Rhabdomyolysis.

Cureus 2022 May 22;14(5):e25201. Epub 2022 May 22.

Internal Medicine, Ascension Providence Hospital, Southfield, USA.

Coxsackie B infections can have varying clinical presentations. Necrotizing myopathy and rhabdomyolysis with remarkably high creatine phosphokinase levels is a rare complication associated with high morbidity and mortality. A 28-year-old male presented with complaints of weakness, body aches, and decreased urine output. Read More

View Article and Full-Text PDF

Severe Rhabdomyolysis Complicated With Acute Kidney Injury Required Renal Replacement Therapy After Pfizer COVID-19 Vaccine  .

Cureus 2022 May 22;14(5):e25199. Epub 2022 May 22.

Internal Medicine, King Abdullaziz Medical City Jeddah, Jeddah, SAU.

The adverse effects of coronavirus disease 2019 (COVID-19) vaccines are somewhat common but rarely life-threatening. Diagnosing life-threatening vaccine-related adverse effects is heavily dependent on history taking and ruling out the other possible causes. Vaccine-related complications vary, so awareness of possible complications can lead to efficient management. Read More

View Article and Full-Text PDF

Suspected Levetiracetam-Induced Acute Rhabdomyolysis in a Patient With Retinoblastoma: A Case Report and Literature Review.

Cureus 2022 May 21;14(5):e25183. Epub 2022 May 21.

Internal Medicine, King Fahad Specialist Hospital, Eastern Health Cluster, Dammam, SAU.

Rhabdomyolysis is a condition characterized by the destruction of the skeletal muscle and the release of its content into the circulation, and it can cause acute kidney injury (AKI). There are numerous causes for the development of this condition, and some of them are rare. Levetiracetam, an antiepileptic agent, has been speculated as a rare possibility for the development of rhabdomyolysis. Read More

View Article and Full-Text PDF

Sports Imaging of COVID-19: A Multi-Organ System Review of Indications and Imaging Findings.

Sports Health 2022 Jun 23:19417381221106448. Epub 2022 Jun 23.

Department of Radiology, NYU Grossman School of Medicine, New York, New York.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in December 2019 in Wuhan, China. Although coronavirus disease-19 (COVID-19) affects every population group, the sports community and athletes require special consideration of the effects on cardiovascular, musculoskeletal, neurologic, and respiratory systems. A comprehensive understanding of imaging indications, findings, and features of COVID-19 supports appropriate imaging utilization and effective patient management and treatment. Read More

View Article and Full-Text PDF

Recurring Weakness in Rhabdomyolysis Following Pfizer-BioNTech Coronavirus Disease 2019 mRNA Vaccination.

Vaccines (Basel) 2022 Jun 11;10(6). Epub 2022 Jun 11.

Department of Neurology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute 480-1195, Japan.

Rhabdomyolysis is a well-known clinical syndrome of muscle injury. Rhabdomyolysis following coronavirus disease 2019 (COVID-19) vaccination has recently been reported. The patients' weakness gradually subsided and did not recur. Read More

View Article and Full-Text PDF

dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury.

Cell Death Differ 2022 Jun 23. Epub 2022 Jun 23.

Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Rhabdomyolysis is a severe condition that commonly leads to acute kidney injury (AKI). While double-stranded DNA (dsDNA) released from injured muscle can be involved in its pathogenesis, the exact mechanism of how dsDNA contributes to rhabdomyolysis-induced AKI (RIAKI) remains obscure. A dsDNA sensor, absent in melanoma 2 (AIM2), forms an inflammasome and induces gasdermin D (GSDMD) cleavage resulting in inflammatory cell death known as pyroptosis. Read More

View Article and Full-Text PDF

Pre-operative exercise and pyrexia as modifying factors in malignant hyperthermia (MH).

Neuromuscul Disord 2022 Jun 11. Epub 2022 Jun 11.

Randall Centre Cell and Molecular Biophysics, Muscle Signalling Section, King's College, London, UK; Department of Paediatric Neurology, Neuromuscular Service, Evelina's Children Hospital, Guy's & St. Thomas' Hospital NHS Foundation Trust, London, UK. Electronic address:

Malignant hyperthermia (MH) is a life-threatening reaction triggered by volatile anesthetics and succinylcholine. MH is caused by mutations in the skeletal muscle ryanodine receptor (RYR1) gene, as is rhabdomyolysis triggered by exertion and/or pyrexia. The discrepancy between the prevalence of risk genotypes and actual MH incidence remains unexplained. Read More

View Article and Full-Text PDF

Exertional rhabdomyolysis following return to exercise after COVID-19 lockdown.

N Z Med J 2022 Feb 4;135(1549):117-119. Epub 2022 Feb 4.

Metabolic Consultant, National Metabolic Service, Auckland City and Starship Children's Hospital.

View Article and Full-Text PDF
February 2022

Case 303: Delayed Posthypoxic Leukoencephalopathy.

Radiology 2022 Jul;304(1):241-244

From the Department of Radiology, University of Ottawa, 501 Smyth Rd, Ottawa, ON, Canada K1H 8L6 (N.R., O.H.A., C.H.T.), and Department of Medical Imaging, The Ottawa Hospital, Ottawa, Canada (O.H.A., C.H.T.).

History: A 54-year-old man was found by paramedics in his home face-down at his computer desk with a substantially reduced level of consciousness. He had not contacted his family for more than 50 hours. The patient lived alone and was a heavy smoker with a history of alcohol abuse. Read More

View Article and Full-Text PDF

DBS emergency surgery for treatment of dystonic storm associated with rhabdomyolysis and acute colitis in DYT-GNAO1.

Childs Nerv Syst 2022 Jun 20. Epub 2022 Jun 20.

Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

Introduction: Patients with variants in the GNAO1 gene may present with life-threatening dystonic storm. There is little experience using pallidal deep brain stimulation (DBS) as an emergency treatment in such cases.

Case Description: We report on a 16-year-old girl with a variant in the GNAO1 gene (c. Read More

View Article and Full-Text PDF

Rhabdomyolysis induced by nelarabine.

Ann Hematol 2022 Jun 17. Epub 2022 Jun 17.

Clinic for Internal Medicine C - Haematology and Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany.

View Article and Full-Text PDF

Editorial Comment to Efficacy of the opened legs position for protecting against postoperative rhabdomyolysis after robot-assisted radical prostatectomy: A propensity score-matched analysis of perioperative outcomes.

Int J Urol 2022 Jun 20. Epub 2022 Jun 20.

Department of Urology, Robotic and Renal Transplant, Vardhaman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

View Article and Full-Text PDF

Phospholipase A inhibitor varespladib prevents wasp sting-induced nephrotoxicity in rats.

Toxicon 2022 Jun 17;215:69-76. Epub 2022 Jun 17.

Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441000, China. Electronic address:

This study aimed to clarify whether varespladib, a phospholipase A (PLA) inhibitor, can be used as a therapeutic agent for wasp sting-induced acute kidney injury (AKI). Rats were divided into control, AKI, and AKI + varespladib groups. The AKI model was established by subcutaneously injecting wasp venom at five different sites in rats. Read More

View Article and Full-Text PDF

The incidence of propofol infusion syndrome in critically-ill patients.

J Crit Care 2022 Jun 17;71:154098. Epub 2022 Jun 17.

New York University Langone Hospital - Long Island, NY, USA.

Purpose: PRIS is a potentially fatal syndrome characterized by various clinical symptoms and abnormalities. Experts suggest that propofol treatment duration ≥48 h or dose ≥83 μg/kg/min is associated with developing PRIS. We hypothesized PRIS might be underdiagnosed due to the overlap of PRIS clinical manifestations with critical illnesses. Read More

View Article and Full-Text PDF

A Rare Case of Cocaine-Induced Muscle Hematoma Followed by Rhabdomyolysis in Association With Acute Kidney Injury and Severe Transaminitis.

Cureus 2022 May 16;14(5):e25035. Epub 2022 May 16.

Medical School, American University of Antigua, New York, USA.

Cocaine use can result in a few infrequent complications, among which is localized hematoma. As far as we know, there are very few cases reporting cocaine-induced non-traumatic muscle hematoma complicated by severe transaminitis and rhabdomyolysis. Here we present a patient who developed a significant lower extremity muscle hematoma secondary to inhalational cocaine use. Read More

View Article and Full-Text PDF

Sickle cell trait and multisystem trauma: an unaddressed urgent knowledge gap.

Trauma Surg Acute Care Open 2022 5;7(1):e000955. Epub 2022 Jun 5.

Department of Surgery, Biological Sciences Division, University of Chicago, Chicago, Illinois, USA.

Sickle cell trait (SCT) has historically been considered a benign condition, but SCT-positive patients have increased baseline risk of venous thromboembolism and chronic kidney disease, as well as increased risk of sickled erythrocytes in settings of hypoxia, acidosis, and hypovolemia. Multisystem traumatic injuries are a common clinical scenario, in which hypoxia, acidosis, and hypovolemia occur; however, little is known about how SCT-positive status impacts outcomes in multisystem trauma. We conducted a scoping literature review to investigate what was known about SCT in the setting of multisystem trauma. Read More

View Article and Full-Text PDF

A Case of Exacerbation of Haloperidol-Induced Rhabdomyolysis Following the Onset of COVID-19.

Am J Case Rep 2022 Jun 20;23:e936589. Epub 2022 Jun 20.

Department of Infectious Diseases, St. Marianna University School of Medicine Hospital, Kawasaki, Kanagawa, Japan.

BACKGROUND Rhabdomyolysis is a condition in which intracellular components are released into the blood and urine. Rhabdomyolysis can be caused by drug-related complications and COVID-19; however, the underlying mechanism is not clear. In this study, we report a case of rhabdomyolysis complicated by COVID-19, in which we presumed that the cause of rhabdomyolysis was related to prior administration of haloperidol by assessment of the drug history and progression of myopathy. Read More

View Article and Full-Text PDF

Drug-induced hyperthermia with rhabdomyolysis in CLN3 disease.

Eur J Paediatr Neurol 2022 Jun 11;39:74-78. Epub 2022 Jun 11.

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Pediatrics, Gothenburg, Sweden. Electronic address:

CLN3 disease (MIM# 204200), the most prevalent of the neuronal ceroid lipofuscinoses (NCL), is an autosomal recessive disorder with juvenile onset characterized by blindness, epilepsy, dementia, psychiatric manifestations, and motor deterioration. Problems related to behavior, emotions and thought are among the main features. Antidepressant and antipsychotic drugs have been employed with variable results. Read More

View Article and Full-Text PDF

Immensely High Creatine Kinase Levels in a Case of Rhabdomyolysis Due to Legionnaires' Disease in a Patient on Tofacitinib: A Case Report and Literature Review.

J Community Hosp Intern Med Perspect 2022 12;12(2):45-49. Epub 2022 Apr 12.

Department of Medicine, Saint Agnes Healthcare, Baltimore, MD, USA.

A 58-year-old female patient presented with altered mental status, diarrhea, and fever. She was hospitalized for acute kidney injury [AKI] and a patchy right lower lobe infiltrates on chest X-ray. Subsequent testing revealed rhabdomyolysis and a positive urinary Legionella antigen test. Read More

View Article and Full-Text PDF

Rhabdomyolysis following snapper fish consumption (Haff disease): a family affair.

BMJ Case Rep 2022 Jun 14;15(6). Epub 2022 Jun 14.

Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

This case describes the first report of Haff disease in Australia, where a family of three all presented with myalgia, after ingesting recently thawed, baked queen snapper fish, caught off the coast of Western Australia. All three members (mother, father and son) developed rhabdomyolysis; however, the son, who had a higher creatine kinase level, also developed an acute kidney injury, likely linked to his double fish consumption. All members were admitted for intravenous hydration and clinically improved. Read More

View Article and Full-Text PDF

Influence of statin treatment in a cohort of patients admitted for COVID-19.

Med Clin (Engl Ed) 2022 Jun 3;158(12):586-595. Epub 2022 Jun 3.

Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.

Aims And Objectives: Statins have been proposed as potentially useful agents for modulating the host response in COVID-19. However, solid evidence-based recommendations are still lacking. Our aim was to study the association between statin use and clinical outcomes in a large cohort of hospitalized patients with SARS-CoV-2 infection, as well as the specific consequences of chronic treatment withdrawal during hospital admission. Read More

View Article and Full-Text PDF

Nelarabine-induced rhabdomyolysis in a patient with T-cell acute lymphoblastic leukemia: a case report.

J Pharm Health Care Sci 2022 Jun 11;8(1):17. Epub 2022 Jun 11.

Division of Pharmacy, Chiba University Hospital, 1-8-1 Inohana Chuo-ku, Chiba, 260-8677, Japan.

Background: Nelarabine is an antineoplastic purine analog used for the treatment of refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL). The most prominent side effect of nelarabine are neurotoxicity and hematologic disorder, which are considered dose-limiting factors. Although clinical studies have reported myopathy due to nelarabine, actual detailed outcomes were not well-known initial approval. Read More

View Article and Full-Text PDF

Extreme Elevation of Creatine Kinase in a Young Male Patient With Recurrent Rhabdomyolysis.

Cureus 2022 May 7;14(5):e24817. Epub 2022 May 7.

Pulmonology and Critical Care, Henry Ford Health System, Detroit, USA.

Rhabdomyolysis is a common cause of admission to the intensive care unit. However, recurrent rhabdomyolysis remains a rare encounter for intensivists and presents a challenge in terms of identifying its etiology. Considerations of metabolic myopathies as a culprit remain underexplored. Read More

View Article and Full-Text PDF

Observational Study of the Association between Hyponatremia and Rhabdomyolysis in Patients Presenting to Hospital.

J Clin Med 2022 Jun 5;11(11). Epub 2022 Jun 5.

Department of General Medicine, Monash Health, Clayton, VIC 3168, Australia.

Hyponatremia may be a risk factor for rhabdomyolysis, but the association is not well defined and may be confounded by other variables. The aims of this study were to determine the prevalence and strength of the association between hyponatremia and rhabdomyolysis and to profile patients with hyponatremia. In a cross-sectional study of 870 adults admitted to hospital with rhabdomyolysis and a median peak creatine kinase of 4064 U/L (interquartile range, 1921-12,002 U/L), glucose-corrected serum sodium levels at presentation showed a U-shape relationship to log peak creatine kinase. Read More

View Article and Full-Text PDF

Rhabdomyolysis as a rare complication of bariatric surgery.

Turk J Surg 2021 Dec 31;37(4):400-402. Epub 2021 Dec 31.

Department of General Surgery, Fırat University Faculty of Medicine, Elazığ, Turkey.

Rhabdomyolysis after bariatric surgery is a quite rare occurrence with low recognition. Due to the breakdown of striated muscle fibers, creatine kinase and myoglobin are released into systemic circulation with variable effects on renal filtering functions. Herein, it was aimed to present a patient who de- veloped rhabdomyolysis following revision bariatric surgery. Read More

View Article and Full-Text PDF
December 2021

Outcomes and genotype correlations in patients with mitochondrial trifunctional protein or isolated long chain 3-hydroxyacyl-CoA dehydrogenase deficiency enrolled in the IBEM-IS database.

Mol Genet Metab Rep 2022 Sep 3;32:100884. Epub 2022 Jun 3.

University of Pittsburgh School of Medicine, USA.

Purpose: Mitochondrial trifunctional protein deficiency (TFPD) and isolated long chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) are two related defects of fatty acid β -oxidation. While NBS has decreased mortality, morbidity remains significant. Additionally, the relationship of genotype to clinical outcome remains unclear. Read More

View Article and Full-Text PDF
September 2022

Rhabdomyolysis and Acute Kidney Injury Associated with Salmonella Infection: A Report of 2 Cases.

Am J Case Rep 2022 Jun 8;23:e936407. Epub 2022 Jun 8.

Department of Internal Medicine, HANSUNG Union Internal Medicine Clinic and Dialysis Center, Daegu, South Korea.

BACKGROUND Rhabdomyolysis is a clinical syndrome characterized by elevated serum creatine kinase (CK) and myoglobin levels due to the breakdown of muscle fibers and is associated with symptoms such as myalgia, muscle swelling, and erythruria. Rhabdomyolysis has an array of potential causes, including Salmonella infection, although rare. We report 2 cases in which nontyphoidal salmonellae caused acute gastroenteritis complicated by rhabdomyolysis and myoglobinuric acute kidney injury (AKI). Read More

View Article and Full-Text PDF

Multiple autoimmune disorders in a patient with neuromyelitis optica spectrum disorder presenting with rhabdomyolysis.

BMJ Case Rep 2022 Jun 7;15(6). Epub 2022 Jun 7.

Internal Medicine, PGIMER, Chandigarh, India

Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating disease of the central nervous system characterised by longitudinal extensive transverse myelitis and involvement of the optic nerve and is associated with many autoimmune disorders. The index case, a known case of Hashimoto's thyroiditis, presented with quadriparesis and tea-coloured urine. Investigations revealed ongoing rhabdomyolysis related to autoimmune myositis and autoimmune haemolytic anaemia leading to pigment-induced acute kidney injury. Read More

View Article and Full-Text PDF

Ulinastatin Alleviates Rhabdomyolysis-Induced Acute Kidney Injury by Suppressing Inflammation and Apoptosis via Inhibiting TLR4/NF-κB Signaling Pathway.

Inflammation 2022 Jun 6. Epub 2022 Jun 6.

Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, Zhejiang, 325000, China.

Acute kidney injury (AKI) is an important complication of rhabdomyolysis (RM), but there is lack of effective treatments. Ulinastatin (UTI) is a broad-spectrum serine protease inhibitor isolated and purified from human urine with strong anti-inflammatory and cytoprotective actions. The aim of this research was to investigate the effect and potential mechanism of UTI on RM-induced AKI (RM-AKI). Read More

View Article and Full-Text PDF

Anesthesia of a patient with congenital cataract, facial dysmorphism, and neuropathy syndrome for posterior scoliosis: A case report.

World J Clin Cases 2022 May;10(13):4207-4213

Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital Brno, Medical Faculty of Masaryk University, Brno 62500, Czech Republic.

Background: Congenital cataract, facial dysmorphism, and neuropathy (CCFDN) syndrome is an extremely rare multiorgan disorder. Characteristics include congenital cataracts, facial deformation, extremity deformities, and demyelinating neuropathy. CCFDN syndrome is associated with increased risk during anesthesia including rhabdomyolysis or epileptic seizures. Read More

View Article and Full-Text PDF