2,224 results match your criteria Rh Incompatibility


Stable Rhodium (IV) Oxide for Alkaline Hydrogen Evolution Reaction.

Adv Mater 2020 May 17:e1908521. Epub 2020 May 17.

Institute of New-Energy Materials, School of Materials Science and Engineering, Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China.

Water electrolysis in alkaline electrolyte is an attractive way toward clean hydrogen energy via the hydrogen evolution reaction (HER), whereas the sluggish water dissociation impedes the following hydrogen evolution. Noble metal oxides possess promising capability for catalyzing water dissociation and hydrogen evolution; however, they are never utilized for the HER due to the instability under the reductive potential. Here it is shown that compressive strain can stabilize RhO clusters and promote their catalytic activity. Read More

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http://dx.doi.org/10.1002/adma.201908521DOI Listing

Minor blood group incompatibility due to blood groups other than Rh(D) leading to hemolytic disease of fetus and newborn: a need for routine antibody screening during pregnancy.

Intractable Rare Dis Res 2020 Feb;9(1):43-47

Department of Neonatology, Maulana Azad Medical College, New Delhi, India.

Minor blood group incompatibility due to blood groups other than Rh(D), although an uncommon cause of neonatal hyperbilirubinemia, has the potential to cause severe hyperbilirubinemia and its sequelae in infants, if left undiagnosed and untreated. Here, we describe clinical presentation, diagnosis and treatment of three cases of minor blood group incompatibility due to anti-E and anti-c antibody. All three neonates presented with pallor, icterus and splenomegaly within the first three days of life. Read More

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http://dx.doi.org/10.5582/irdr.2019.01094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062592PMC
February 2020

Influence of family environment on the development of speech and language in pre-lingually deaf children after cochlear implantation.

Clin Otolaryngol 2020 Mar 5. Epub 2020 Mar 5.

Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of AnHui Medical University, Hefei, China.

Objective: To investigate the influence of family environment on the development of speech and language in pre-school children after cochlear implantation.

Methods: A total of 88 pre-lingually deaf children, aged 2-5 years, who received cochlear implantation, were included in this study. All families completed a self-report family environment questionnaire (FES). Read More

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http://dx.doi.org/10.1111/coa.13525DOI Listing

Changes in Mean Corpuscular Volume and RBC Distribution Width Predict Erythrocyte Engraftment Following ABO-Incompatible Hematopoietic Stem Cell Transplantation.

Am J Clin Pathol 2020 May;153(6):781-789

Department of Pathology, Virginia Commonwealth University, Richmond.

Objectives: The purpose of this study was to identify laboratory parameters representing erythrocyte engraftment to be used as an indicator to change the recipient to donor ABO group and Rh type following an ABO-incompatible hematopoietic stem cell transplant (HSCT). Studies have shown that ABO incompatibility does not have an effect on outcome of HSCT; however, the serologic consequences of these ABO-incompatible transplants can make it difficult to decide when to begin support with donor ABO/Rh-type blood products.

Methods: This study explored the use of RBC distribution width (RDW), mean corpuscular volume, and hemoglobin as regularly tested laboratory parameters that could be used as surrogate markers for RBC engraftment in 65 patients who received ABO/Rh-incompatible HSCT. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa006DOI Listing

Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis.

World J Pediatr 2020 Feb 12. Epub 2020 Feb 12.

Student Research Committee, Babol University of Medical Sciences, Babol, Iran.

Background: Jaundice is a life-threatening disorder in the neonates. In the present study, we aimed to assess systematically available evidence on causes and management of jaundice in Iranian newborn patients.

Methods: We searched the databases of PubMed, Web of Sciences, Scopus and Google Scholar for English articles published since inception until May 2019. Read More

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http://dx.doi.org/10.1007/s12519-020-00339-3DOI Listing
February 2020

Professional barriers and facilitators to using stratified care approaches for managing non-specific low back pain: a qualitative study with Canadian physiotherapists and chiropractors.

Chiropr Man Therap 2019 13;27:68. Epub 2019 Dec 13.

1School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, 3630 Promenade Sir-William-Osler, H3G 1Y5, Montreal, QC Canada.

Background: Recent clinical practice guidelines for the management of non-specific low back pain (LBP) recommend using stratified care approaches. To date, no study has assessed barriers and facilitators for health professionals in using stratified care approaches for managing non-specific LBP in the Canadian primary care setting. This study aimed to identify and contrast barriers and facilitators to using the stratified care approaches for non-specific LBP among Canadian physiotherapists and chiropractors. Read More

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http://dx.doi.org/10.1186/s12998-019-0286-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909494PMC
February 2020

Intravenous Immunoglobulins as Adjunct Treatment to Phototherapy in Isoimmune Hemolytic Disease of the Newborn: A Retrospective Case-Control Study.

J Clin Med Res 2019 Nov 29;11(11):760-763. Epub 2019 Oct 29.

Jordan University Hospital, The University of Jordan, Amman, Jordan.

Background: Isoimmune hemolytic disease is a major cause of neonatal severe indirect hyperbilirubinemia that requires phototherapy or exchange transfusion which is an invasive procedure to avoid brain injury. Administration of intravenous immunoglobulin (IVIG) is used as an adjunct treatment to phototherapy in order to decrease the rate of exchange transfusion.

Methods: This retrospective case-control study aimed to describe the safety and efficacy of IVIG therapy in newborns with isoimmune hemolytic disease and to compare their clinical outcomes to those of a control group who were treated only with phototherapy. Read More

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http://dx.doi.org/10.14740/jocmr4003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879023PMC
November 2019

Hemolytic anemia caused by non-D minor blood incompatibilities in a newborn.

Pan Afr Med J 2019 29;33:262. Epub 2019 Jul 29.

Baskent University Ankara Hospital, Department of Pediatrics, Division of Neonatology, Ankara, Turkey.

Hyperbilirubinemia is one of the most widely seen cause of neonatal morbidity. Besides ABO and Rh isoimmunization, minor blood incompatibilities have been also been identified as the other causes of severe newborn jaundice. We report a newborn with indirect hyperbilirubinemia caused by minor blood group incompatibilities (P1, M, N, s and Duffy) whose hemolysis was successfully managed with intravenous immunoglobulin therapy. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.262.19324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814938PMC
November 2019

NT-proBNP: A Useful Biochemical Marker for Prognosis in Rh-Isoimmunized Pregnancies.

J Obstet Gynaecol India 2019 Oct 1;69(Suppl 2):128-132. Epub 2018 Oct 1.

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, 110029 India.

Background: Rh incompatibility sometimes results in life-threatening conditions in fetus like severe anemia and jaundice, leading to kernicterus and even death. Even after an uneventful intrauterine transfusion (IUT), fetus may not survive despite correction of the fetal anemia. Finding appropriate markers may help in determining the prognosis of such cases. Read More

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http://dx.doi.org/10.1007/s13224-018-1180-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801230PMC
October 2019

Exchange transfusion in neonatal hyperbilirubinemia: A single Centre experience from Northern India.

Transfus Apher Sci 2019 Dec 4;58(6):102655. Epub 2019 Oct 4.

Department of Transfusion Medicine and Immunology, Indraprastha Apollo Hospitals, New Delhi, 110076, India.

Objective: To determine the indication, efficacy and adverse events related to exchange transfusion (ET) with reconstituted blood (RB) in neonatal hyperbilirubinemia (NNH).

Methods: Blood bank records of neonates who underwent double volume ET for NNH from January 2013 to July 2018 were retrospectively reviewed. Demographic details, cause of NNH, details of ET and ET related adverse events were recorded. Read More

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http://dx.doi.org/10.1016/j.transci.2019.09.008DOI Listing
December 2019
1 Read

Isoantibodies, prevalence and risk factors in two hospitals in Mexico

Rev Med Inst Mex Seguro Soc 2019 Jul 31;57(2):88-96. Epub 2019 Jul 31.

Instituto de Seguridad Social del Estado de México y Municipios, Centro Médico Toluca, Departamento de Medicina Transfusional. Metepec, Estado de México, México

Background: Erythrocyte isoimmunization or alloimmunization is a late complication of transfusion, in which antibodies against erythrocyte antigens other than the ABO system are developed. Its prevalence is variable, groups of patients with low prevalence (2%) and others of high risk with more than 50% have been described. These antibodies can have serious clinical repercussions in transfused patients. Read More

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July 2019
1 Read

Safety issues related to the electronic cross-matching of blood in mainland China: A prospective cohort study involving cross-matching of 40,228 blood samples.

Medicine (Baltimore) 2019 Aug;98(35):e16703

Intensive Care Unit, Suining Central Hospital, An Affiliated Hospital of Chongqing University, Suining, Sichuan, China.

Although the electronic cross-matching of blood has been widely applied in some developed countries and regions, concern over the risk of undetected red blood cell (RBC) antibodies has limited its application in mainland China.This study was performed to explore the missed detection rate of RBC antibodies in a Chinese population from 2011 to 2016. If the results of 2 consecutive tests of ABO/RhD blood group identification were consistent and antibody screening results were negative, electronic cross-matching of the blood was performed. Read More

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http://Insights.ovid.com/crossref?an=00005792-201908300-0001
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http://dx.doi.org/10.1097/MD.0000000000016703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736444PMC
August 2019
4 Reads

Impact of ABO blood group incompatibility on the outcomes of allogeneic hematopoietic stem cell transplantation.

Transfus Apher Sci 2020 Feb 10;59(1):102597. Epub 2019 Jul 10.

Hacettepe University, Faculty of Medicine, Department of Hematology, Turkey.

Background And Aim: ABO and Rh compatibility are not required between the donor and recipient for allogeneic hematopoietic stem cell transplantation (alloHSCT). Although ABO incompatibility is not considered a contraindication in alloHSCT, its clinical outcomes are still doubtful. In this study, we analyzed the neutrophil and platelet recovery, graft versus host disease (GVHD), relapse rate, mortality rate, non-relapse mortality and survival in patients who underwent alloHSCT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14730502193012
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http://dx.doi.org/10.1016/j.transci.2019.06.024DOI Listing
February 2020
5 Reads
1.072 Impact Factor

ADVANCING TRANSFUSION MEDICINE IN SEA TURTLES: OPTIMIZATION OF A CROSS-MATCHING PROTOCOL.

J Zoo Wildl Med 2019 Jun 13;50(2):315-321. Epub 2019 Jun 13.

University of Florida College of Veterinary Medicine, Department of Comparative, Diagnostic, and Population Medicine, Gainesville, FL 32608, USA.

Whole blood transfusions are an essential treatment modality during rehabilitation of stranded sea turtles, however, standardized protocols for transfusions are not available in reptile medicine. The objective of this study was to optimize a cross-matching protocol for sea turtle blood transfusions. Fresh venous blood samples from 15 turtles ( = 14 green turtles, [Cm]; = 1 loggerhead sea turtle, [Cc]) were tested using a temperature-appropriate (i. Read More

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https://bioone.org/journals/journal-of-zoo-and-wildlife-medi
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http://dx.doi.org/10.1638/2018-0062DOI Listing
June 2019
11 Reads

Compatibility Between Four Anti-TB Drugs and Tablet Excipients Determined By Microcalorimetry.

Pharmazie 2019 06;74(6):350-351

Previous isothermal microcalorimetry studies at 40 °C, with and without humidity (RH 75%), had shown no incompatibility between rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA) and ethambutol HCl (EMB). The purpose of this study was to explore any interactions at an increased temperature of 50 °C and also to investigate the possibility of incompatibilities between the drugs and tablet excipients used in the most commonly prescribed commercial four-drug TB FDC. No incompatibilities were observed between the excipients, or when the excipients were tested with the four drugs individually. Read More

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http://dx.doi.org/10.1691/ph.2019.8189DOI Listing
June 2019
9 Reads

Magnitude of Neonatal Jaundice and Its Associated Factor in Neonatal Intensive Care Units of Mekelle City Public Hospitals, Northern Ethiopia.

Int J Pediatr 2019 10;2019:1054943. Epub 2019 Apr 10.

College of Health Sciences and Medicine, Wolaita Sodo University, Sodo, Ethiopia.

Background: Jaundice in the neonate is one of the most common clinical problems. Globally, every year about 1.1 million babies develop it and the vast majority reside in sub-Saharan Africa and South Asia. Read More

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https://www.hindawi.com/journals/ijpedi/2019/1054943/
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http://dx.doi.org/10.1155/2019/1054943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481120PMC
April 2019
6 Reads

Case Report of Anemia Following Fetal-Maternal Hemorrhage.

Authors:
Kristi L Coe

Adv Neonatal Care 2019 Jun;19(3):198-204

Wake Forest Baptist Health, Pediatric Critical Care Transport, Winston-Salem, North Carolina; Duke University School of Nursing, Durham, North Carolina; Cone Health, NICU, Greensboro, North Carolina; and University of North Carolina at Greensboro, Nursing PhD program, Greensboro, NC.

Background: Any maternal history of blood loss, ABO or Rh incompatibility, and hydrops fetalis often leads to suspicion of neonatal anemia postnatally. When maternal history consists only of decreased fetal movement, recognition of neonatal anemia can be problematic.

Clinical Findings: This case was a transported late preterm neonate who presented initially with persistent hypoxia unresponsive to usual respiratory support. Read More

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http://dx.doi.org/10.1097/ANC.0000000000000618DOI Listing
June 2019
13 Reads

Evaluation of Automatic Blood Analyzer as Screening Method in Fetomaternal Hemorrhage.

Biomed Res Int 2019 26;2019:6481654. Epub 2019 Feb 26.

Department of Obstetrics and Gynecology, University of Campinas School of Medicine, Rua Alexander Fleming 101, 13083-891 Campinas, Brazil.

Screening of fetomaternal hemorrhage (FMH) is essential in management of fetomaternal antigen incompatibilities of blood. The objective in this study was to evaluate the ability of automatic blood analyzer (ABA) to screen FMH, also comparing this method with flow cytometry (FCM). The contents of fetal red blood cells and fetal hemoglobin were evaluated by FCM and ABA, respectively, using both blood samples of male adults laced with umbilical cord blood diluted at 1/10, 1/100, 1/1,000, and 1/10,000, or blood from puerperal women collected within 48 hours following delivery. Read More

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http://dx.doi.org/10.1155/2019/6481654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413365PMC
July 2019
8 Reads

Immuno-hematological findings in Delayed Hemolytic Transfusion Reaction (DHTR).

Authors:
V Thonier

Transfus Clin Biol 2019 May 22;26(2):102-108. Epub 2019 Feb 22.

Centre national de référence pour les groupes sanguins (CNRGS), Institut national de la transfusion sanguine (INTS), Paris cedex 11, France. Electronic address:

Sickle cell disease (SCD) is the most prevalent genetic disorder in France. Many other countries are also affected. Transfusion is still a key treatment for patients suffering from this condition. Read More

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http://dx.doi.org/10.1016/j.tracli.2019.02.006DOI Listing
May 2019
2 Reads

[Immuno-hematological follow up of pregnant women].

Rev Prat 2018 May;68(5):541-546

Unité clinique du centre national de référence en hémobiologie périnatale, service de médecine foetale, pôle ORGYNE, hôpital Trousseau, AP-HP, Paris, France.

Immuno-hematological follow up of pregnant women. The goal of immuno-hematological follow-up during pregnancy is to organize maternal transfusion safety and optimal management of fetal and neonatal hemolytic disease, that may result from maternal immunization. This follow-up relies on scheduled antibodies detection following regulation. Read More

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May 2018
5 Reads

The disappearance of blood group antigens: A clue to the clinical diagnosis of leukemia.

Transfus Apher Sci 2019 Feb 5;58(1):48-49. Epub 2018 Dec 5.

Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education. Electronic address:

A 54-year-old male patient was admitted with low-grade intermittent fever not associated with chills. The cell grouping of the patient sample showed O Rh D positive and serum grouping as B, with a discrepancy to be resolved. Series of immunohematological workup was performed to rule out the discrepancy. Read More

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http://dx.doi.org/10.1016/j.transci.2018.11.010DOI Listing
February 2019
9 Reads

The self-care dilemma of type 2 diabetic patients: The mechanism of self-regulation resource depletion.

PLoS One 2018 6;13(12):e0208690. Epub 2018 Dec 6.

CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.

Self-care is important for type 2 diabetes mellitus (T2DM) patients' disease prognosis, but there is a common phenomenon of self-regulation failure in T2DMs. In order to figure this problem out, the current study explored the interaction between self-regulation resource depletion and diabetes self-care based on the limited resource model of self-regulation. 104 patients were surveyed using the Self-Regulatory Fatigue Scale (SRF-S) and the Diabetes Self-care Scale (DSCS) in study 1. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208690PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283625PMC
May 2019
10 Reads

Multiplex blood group typing by cellular surface plasmon resonance imaging.

Transfusion 2019 02 29;59(2):754-761. Epub 2018 Nov 29.

Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Blood-group typing of donors and patients is essential to avoid incompatible transfusions. Transfusion of incompatible RBCs may result in alloimmunization complicating future transfusions or in the presence of antibodies in adverse reactions. With more than 300 blood group antigens identified, it is difficult to provide fully compatible blood. Read More

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http://dx.doi.org/10.1111/trf.15071DOI Listing
February 2019
31 Reads

Pregnancy Outcomes Of Consanguinity Among Antenatal Patients Attending Combined Military Hospital Quetta, Pakistan.

J Ayub Med Coll Abbottabad 2018 Jul-Sep;30(3):423-427

Combined Military Hospital Quetta, Pakistan.

Background: All definitions of consanguinity encompass the basic concept of close blood relation. Highest rates of consanguineous unions are observed for North and Sub Saharan Africa, Middle East, and west, central and south Asia, where 20-50% marriages are consanguineous. In Pakistan, we can hardly find any rigorous research on the pregnancy outcomes of consanguinity except those conducted by Allan Bittles. Read More

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January 2019
33 Reads

Biocatalyst-artificial metalloenzyme cascade based on alcohol dehydrogenase.

Chem Sci 2018 Oct 14;9(38):7447-7454. Epub 2018 Aug 14.

Faculty of Engineering , University of Nottingham , University Park, NG7 2RD , Nottingham , UK . Email:

Chemo-enzymatic cascades of enzymes with transition metal catalysts can offer efficient synthetic strategies, but their development is challenging due to the incompatibility between proteins and transition metal complexes. Rhodium catalysts can be combined with alcohol dehydrogenases to regenerate nicotinamide cofactors using formate as the hydride donor. However, their use is limited, due to binding of the metals to residues on the enzyme surface, leading to mutual enzyme and catalyst inactivation. Read More

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http://xlink.rsc.org/?DOI=C8SC02371A
Publisher Site
http://dx.doi.org/10.1039/c8sc02371aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180310PMC
October 2018
38 Reads

Somatic mosaicisms of chromosome 1 at two different stages of ontogenetic development detected by Rh blood group discrepancies.

Haematologica 2019 03 20;104(3):632-638. Epub 2018 Sep 20.

Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Austria

Spontaneous Rh blood group changes are a striking sign, reported to occur mainly in patients with hematologic disorders. Upon routine blood grouping, 2 unrelated individuals showed unexplained mixed red cell phenotype regarding the highly immunogenic c antigen (RH4), clinically relevant for blood transfusion and fetomaternal incompatibility. About half of their red cells were c-positive, whereas the other half were c-negative. Read More

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http://dx.doi.org/10.3324/haematol.2018.201293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395338PMC
March 2019
11 Reads

Impact of Red Blood Cell Antigen Matching on Alloimmunization and Transfusion Complications in Patients with Sickle Cell Disease: A Systematic Review.

Transfus Med Rev 2019 01 26;33(1):12-23. Epub 2018 Jul 26.

Department of Hematology & Oncology, Emory University School of Medicine, Atlanta, GA.

Red blood cells (RBC) transfusion is critical in managing acute and chronic complications in sickle cell disease (SCD); however, it is complicated by RBC alloimmunization, iron overload, transfusion reactions and infection. Several reports documented an increased incidence of alloantibodies in transfused individuals with SCD, especially for Rh and Kell antigens. As a result, the National Institutes of Health Expert Panel and British Society for Haematology guidelines recommend primary matching for C/c, E/e and K antigens in addition to ABO/RhD for RBC transfusions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08877963183004
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http://dx.doi.org/10.1016/j.tmrv.2018.07.003DOI Listing
January 2019
63 Reads

Is Cord Blood Bilirubin Level a Reliable Predictor for Developing Significant Hyperbilirubinemia?

Am J Perinatol 2019 02 6;36(3):317-321. Epub 2018 Aug 6.

Department of Pediatrics, Gaziosmanpasa Taksim Research and Training Hospital, Istanbul, Turkey.

Objective: We aimed to investigate whether cord blood bilirubin (CBB) level could be used to identify the newborns at a high risk of developing hyperbilirubinemia.

Study Design: Total and direct serum bilirubin level were evaluated from umbilical cord blood of newborns. We checked blood groups and Rh status of all mothers and determined blood groups and direct Coombs test (DC) of newborns born to mothers whose blood group was O type or Rh negative to determine the maternal-fetal blood group or Rh incompatibility. Read More

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http://dx.doi.org/10.1055/s-0038-1667368DOI Listing
February 2019
17 Reads

B/L Basal Ganglia Lesions in a Child Leading to a Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency.

Ann Neurosci 2018 Apr 21;25(1):50-52. Epub 2017 Nov 21.

Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.

Bilateral basal ganglia lesions are a common non-specific finding seen in many diseases. One of the differential diagnoses for it, in a child, is kernicterus occurring due to hyperbilirubinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of severe hyperbilirubinemia. Read More

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https://www.karger.com/Article/FullText/481907
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http://dx.doi.org/10.1159/000481907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981589PMC
April 2018
30 Reads

A new biosensor for noninvasive determination of fetal RHD status in maternal blood of RhD negative pregnant women.

PLoS One 2018 6;13(6):e0197855. Epub 2018 Jun 6.

Department of Medical Biochemistry, Faculty of Medicine, University of Cukurova, Adana, Turkey.

Prenatal detection of the fetal RHD status can be useful in the management of RhD incompatibility to identify fetuses at risk of hemolytic disease. Hemolytic disease causes morbidity and mortality of the fetus in the neonatal period. The routine use of antenatal and postnatal anti-D prophylaxis has reduced the incidence of hemolytic disease of the fetus and newborn. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197855PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991352PMC
December 2018
20 Reads

Degradation caused by incompatibility between sodium stearyl fumarate (PRUV) and AZD7986 in the drug product.

J Pharm Biomed Anal 2018 Sep 22;158:82-87. Epub 2018 May 22.

Early Product Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.

During compatibility study of the AZD7986 project, a peak of 3 area% at the tail (RRT 1.03) of the active pharmaceutical ingredient (API) was discovered for all tablets containing sodium stearyl fumarate (PRUV) under humid condition (e.g. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183086
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http://dx.doi.org/10.1016/j.jpba.2018.05.036DOI Listing
September 2018
125 Reads

Umbilical cord blood bilirubins, gestational age, and maternal race predict neonatal hyperbilirubinemia.

PLoS One 2018 1;13(6):e0197888. Epub 2018 Jun 1.

Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California Los Angeles, UCLA Mattel Children's Hospital, Los Angeles, California, United States of America.

Objective: No validated biomarker at birth exists to predict which newborns will develop severe hyperbilirubinemia. This study's primary aim was to build and validate a prediction model for severe hyperbilirubinemia using umbilical cord blood bilirubins (CBB) and risk factors at birth in neonates at risk for maternal-fetal blood group incompatibility. This study's secondary aim was to compare the accuracy of CBB to the direct antigen titer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197888PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983417PMC
December 2018
19 Reads

UV/O3 treatment as a surface modification of rice husk towards preparation of novel biocomposites.

PLoS One 2018 30;13(5):e0197345. Epub 2018 May 30.

School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.

The use of rice husks (RH) to reinforce polymers in biocomposites are increasing tremendously. However, the incompatibility between the hydrophilic RH fibers and the hydrophobic thermoplastic matrices leads to unsatisfactory biocomposites. Surface modification of the fiber surface was carried out to improve the adhesion between fiber and matrix. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197345PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976143PMC
December 2018
8 Reads

Learning from claims: hyperbilirubinaemia and kernicterus.

Arch Dis Child Fetal Neonatal Ed 2019 Mar 25;104(2):F202-F204. Epub 2018 May 25.

Maternity and Newborn, NHS Improvement, London, UK.

We examined claims made against the National Health Service (NHS) involving neonatal jaundice in order to determine whether there were lessons that could be learnt from common themes.This was a retrospective anonymised study using information from the NHS Resolution database for 2001-2011.Twenty cases (16 males) had sufficient information for analysis. Read More

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http://dx.doi.org/10.1136/archdischild-2017-314622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580733PMC
March 2019
44 Reads

[Clinical analysis of seven cases of rare hemolytic disease of the newborn].

Zhonghua Er Ke Za Zhi 2018 May;56(5):369-372

Department of Neonatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To summarize the clinical features of 7 rare cases of hemolytic disease of newborn (HDN), and to improve the understanding of rare HDN. Data of clinical information, laboratory findings, treatments and outcomes were collected and analyzed for four cases with HDN due to anti-M, two cases due to anti-Kidd, and one case due to anti-Duffy. All of them were admitted to the Department of Neonatology, Beijing Children's Hospital Affiliated to Capital Medial University from July 2007 to June 2017. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.05.012DOI Listing
May 2018
7 Reads

Feminine identity and functional benefits are key factors in women's decision making about upper limb prostheses: a case series.

Disabil Rehabil Assist Technol 2019 02 9;14(2):194-208. Epub 2018 May 9.

b Ocean State Research Institute Research , Providence , RI , USA.

Purpose: Although the DEKA Arm promises new abilities, it is unclear if women with upper limb amputation are willing to avail themselves of this new technology. The study purpose was to understand key factors and tradeoffs that shape women's attitudes towards the DEKA Arm.

Methods: This case series includes three women with transradial amputation. Read More

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http://dx.doi.org/10.1080/17483107.2018.1467973DOI Listing
February 2019
7 Reads

Transfusion policy in allogeneic hematopoietic stem cell transplantation.

Authors:
Pervin Topcuoglu

Transfus Apher Sci 2018 Apr 18;57(2):174-177. Epub 2018 Apr 18.

Ankara University, School of Medicine, Turkey. Electronic address:

The incompatibility of ABO blood group between the recipient and the donor is not a barrier to perform allogeneic hematopoietic stem cell transplantation (Allo-HSCT). However, ABO incompatibility may lead to many complications during and after stem cell transplantation at the early or late period. Therefore, the typing of the blood group of the recipient and the donor should be done prior to the transplantation. Read More

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http://dx.doi.org/10.1016/j.transci.2018.04.017DOI Listing
April 2018
12 Reads

Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.

EMBO Mol Med 2018 06;10(6)

School of Biochemistry, University of Bristol, Bristol, UK

Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR-mediated genome editing of an immortalised human erythroblast cell line (BEL-A) to generate multiple enucleation competent cell lines deficient in individual blood groups. Read More

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http://dx.doi.org/10.15252/emmm.201708454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991592PMC
June 2018
18 Reads
8.660 Impact Factor

ABO incompatibility and RhIG immunoprophylaxis protect against non-D alloimmunization by pregnancy.

Transfusion 2018 07 6;58(7):1611-1617. Epub 2018 Apr 6.

Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam.

Background: Hemolytic disease of the fetus and newborn (HDFN) is caused by maternal antibodies against fetal red blood cell antigens, most often anti-D, -K, or -c. ABO incompatibility between mother and child and anti-D immunoprophylaxis (RhIG) are known to reduce the risk of D immunization and subsequent HDFN. However, no immunoprophylaxis has been developed to prevent non-D immunizations. Read More

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http://dx.doi.org/10.1111/trf.14606DOI Listing
July 2018
76 Reads

An approach to incompatible cross-matched red cells: Our experience in a major regional blood transfusion center at Kolkata, Eastern India.

Asian J Transfus Sci 2018 Jan-Jun;12(1):51-56

Department of Immunohaematology and Blood Transfusion, Kolkata Medical College, Kolkata, West Bengal, India.

Introduction: With the increased utilization of immunohematology (IH) analyzers in the transfusion medicine, type, and screen policy is the method of choice. Still, the importance of routine crossmatching could not be overruled. Here, we tried to understand the clinical conditions and safety of red cell transfusion and their outcomes. Read More

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http://dx.doi.org/10.4103/ajts.AJTS_157_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850698PMC
March 2018
9 Reads

Maternal-fetal Rhesus (Rh) factor incompatibility in Arar, northern Saudi Arabia.

Electron Physician 2017 Dec 25;9(12):5908-5913. Epub 2017 Dec 25.

Intern, Faculty of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia.

Background And Aim: Rh isoimmunization still contributes to the neonatal morbidity and mortality due to non-immunization, under-immunization, and in rare cases, false Rh typing. The main objective of this study was to determine the prevalence of Rh incompatibility, mothers' knowledge about Rh incompatibility, mothers' knowledge about anti-D immunoglobulin and to show the pregnancy outcome of Rh negative mothers.

Methods: A cross-sectional study was carried out at the Maternity and Children Hospital in Arar city from November 2016 to May 2017. Read More

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http://www.ephysician.ir/index.php/browse-issues/2017/12/903
Publisher Site
http://dx.doi.org/10.19082/5908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843415PMC
December 2017
19 Reads

Immunoglobulin for alloimmune hemolytic disease in neonates.

Cochrane Database Syst Rev 2018 03 18;3:CD003313. Epub 2018 Mar 18.

Department of Obstetrics, Leiden University Medical Center, Leiden, Netherlands.

Background: Exchange transfusion and phototherapy have traditionally been used to treat jaundice and avoid the associated neurological complications. Because of the risks and burdens of exchange transfusion, intravenous immunoglobulin (IVIg) has been suggested as an alternative therapy for alloimmune hemolytic disease of the newborn (HDN) to reduce the need for exchange transfusion.

Objectives: To assess the effect and complications of IVIg in newborn infants with alloimmune HDN on the need for and number of exchange transfusions. Read More

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http://dx.doi.org/10.1002/14651858.CD003313.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494160PMC
March 2018
60 Reads

Is the management of Rh-Rh incompatibility with noninvasive fetal Rh genotyping for targeted prophylaxis cost-effective in the Turkish population?

Turk J Med Sci 2018 Feb 23;48(1):1-4. Epub 2018 Feb 23.

Background/aim: The aim of this study was to assess unnecessary immunization rates and compare the cost-effectiveness of targeted prophylaxis with fetal Rh genotyping with that of traditional management of Rh-Rh incompatibility in a virtual economic model. Materials and methods: This retrospective data analysis was conducted at two tertiary centers between 2011 and 2015. The data of 1135 pregnant women were analyzed. Read More

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http://dx.doi.org/10.3906/sag-1511-87DOI Listing
February 2018
11 Reads

Evaluation of Risk Factors for Exchange Range Hyperbilirubinemia and Neurotoxicity in Neonates from Hilly Terrain of India.

Int J Appl Basic Med Res 2017 Oct-Dec;7(4):228-232

Department of Pediatrics, Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India.

Background And Aim: Neonatal hyperbilirubinemia continues to be the most common cause of hospital admissions and readmissions in the neonatal population worldwide and this pattern continues despite attempts to identify neonates at risk of pathological hyperbilirubinemia. Therefore, this study aimed to study the risk factors for severe hyperbilirubinemia in neonates.

Materials And Methods: An observational prospective study was undertaken for 1 year in neonates with hyperbilirubinemia requiring double volume exchange transfusion in neonatology unit of a tertiary rural health care hospital. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_298_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752806PMC
January 2018
13 Reads

Do triple test results predict risk for neonatal hyperbilirubinemia?

Pak J Med Sci 2017 Jul-Aug;33(4):979-983

Merih Cetinkaya, Assistant Professor, Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

Objective: Neonatal jaundice is the most common condition that requires hospital admission and outpatient follow-up after discharge in neonates. The values of more than 17 mg/dL in term infants are accepted as neonatal significant hyperbilirubinemia. We aimed to define if there is any relationship between second trimester serum markers and neonatal severe hyperbilirubinemia to protect the neonates from its neurological damage. Read More

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http://dx.doi.org/10.12669/pjms.334.12420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648976PMC
October 2017
14 Reads

Hyperbilirubinemia due to minor blood group (anti-E) incompatibility in a newborn: a case report.

Turk Pediatri Ars 2017 Sep 1;52(3):162-164. Epub 2017 Sep 1.

Department of Pediatrics, Division of Neonatology, Ufuk University Faculty of Medicine, Ankara, Turkey.

In addition to Rh and ABO incompatibilities subgroup incompatibilities may rarely play a role among the causes of hemolytic anemia and indirect hyperbilirubinemia in newborns. The most common minor blood group antigens that cause blood incompatibility between the mother and baby are C, c, E, e, Kell, Duffy, Diego, Kidd and MNSs antigens. In this article, a newborn in whom hyperbilirubinemia due to anti-E minor blood group incompatibility developed and was treated with phototherapy succesfully is presented and minor blood group incompatibilities due to anti-E are reviewed. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2017.2658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644583PMC
September 2017
8 Reads

Rhesus Alloimunization Occurs After Rh Incompatible Liver Transplantation in Children.

Transplantation 2018 01;102(1):e1

Department of Gastroenterology and Clinical Nutrition, The Royal Children's Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1097/TP.0000000000001976DOI Listing
January 2018
16 Reads

Genotyping to prevent Rh disease: has the time come?

Curr Opin Hematol 2017 Nov;24(6):544-550

aSanquin Research, Department of Experimental Immunohematology bLandsteiner Laboratory, Academic Medical Centre, University of Amsterdam cSanquin Diagnostic Services, Department of Immunohematology Diagnostics, Amsterdam dSanquin Research, Department of Immunohematology and Blood Transfusion, Center for Clinical Transfusion Research, Leiden and Leiden University Medical Center, Leiden, The Netherlands eDepartment of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Purpose Of Review: In this review, we analyzed the current literature on noninvasive fetal RHD typing to answer the question whether the administration of RhIg to prevent D-alloimmunization during pregnancy can be safely guided by fetal RHD typing.

Recent Findings: Recently the first centers that implemented large-scale nationwide fetal RHD typing in the second trimester for targeted RhIg administration have published their studies evaluating the diagnostic accuracy of their screening programs. These data show that fetal RHD typing in a routine setting is, at least in a population of European descent, accurate enough to guide both antenatal and postnatal immunoprophylaxis. Read More

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http://Insights.ovid.com/crossref?an=00062752-201711000-0001
Publisher Site
http://dx.doi.org/10.1097/MOH.0000000000000379DOI Listing
November 2017
57 Reads