2,294 results match your criteria Rh Incompatibility


Rheumatic Diseases in Reproductive Age-the Possibilities and the Risks.

Reprod Sci 2022 Mar 31. Epub 2022 Mar 31.

Department of Rheumatology, Rehabilitation and Internal Diseases, Poznan University of Medical Sciences, 28 Czerwca Street 135/147, 60-545, Poznań, Poland.

The most common systemic connective tissue diseases (CTD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis (SSc), and Sjögren's syndrome (SjS), affect many women of reproductive age. These diseases may strongly impact the course of pregnancy and increase the risk factors of incompatibility. A literature search was done on MEDLINE, PubMed, and Google Scholar in 2011-2021. Read More

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Retrospective analysis of direct antiglobulin test positivity at tertiary academic hospital over 10 years.

Transfus Apher Sci 2022 Jan 19:103358. Epub 2022 Jan 19.

Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Sq., 917798564, Mashhad, Iran. Electronic address:

Background: Hemolytic disease of the fetus and newborn (HDFN) is a clinically significant problem that may potentially affect any pregnancy. Direct antiglobulin test (DAT) is considered to be an important test in identifying newborns who are suspected to have HDN. This study aims in reviewing data regarding a positive DAT result concerning etiology and the development of HDN over a period of 10 years. Read More

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January 2022

Impact of and Reasons for Not Performing Exercise Training After an Acute Coronary Syndrome in the Setting of an Interdisciplinary Cardiac Rehabilitation Program: Results From a Risk-Op- Acute Coronary Syndrome Ambispective Registry.

Front Physiol 2021 24;12:768199. Epub 2021 Nov 24.

Heart Diseases Biomedical Research Group, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Exercise training (ET) is a critical component of cardiac rehabilitation (CR), but it remains underused. The aim of this study was to compare clinical outcomes between patients who completed ET (A-T), those who accepted ET but did not complete it (A-NT), and those who did not accept to undergo it (R-NT), and to analyze reasons for rejecting or not completing ET. A unicenter ambispective observational registry study of 497 patients with acute coronary syndrome (ACS) was carried out in Barcelona, Spain, from 2016 to 2019. Read More

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November 2021

[Transfusion Strategy for Rare Anti-LW Antibody Autoimmune Hemolytic Anemia Patients with Neonatal Hemolytic Disease].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Dec;29(6):1935-1939

Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou 450018, Henan Province, China.

Objective: To analyze the causes of positive irregular antibody screening test and incompatibility of cross matching in one patient with autoimmune hemolytic anemia complicated with neonatal hemolytic disease, and to accurately identify the type of antibodies in patients, and to select a reasonable strategy for blood transfusion.

Methods: One children was enrolled, blood group positive and reverse typing, Rh typing, direct anti-human globulin test, free test, dispersal test and cross matching test were carried out by test tube method and microcolumn gel card; irregular antibodies were identified by the reaction of DTT treatment and untreated panel cells with patients' plasma.

Results: The blood group of the patient was RhD positive B and irregular antibody screening positive, while the blood group of the mother was RhD positive O and irregular anti-screening negative, the result showed that the anti-LW detected in the plasma of the patient was autoantibody and ABO neonatal hemolytic disease (ABO-HDN) was present. Read More

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December 2021

Hemolysis in Early Infancy: Still a Cause of Cholestatic Neonatal Giant Cell Hepatitis.

Am J Surg Pathol 2022 Jun 1;46(6):801-808. Epub 2021 Dec 1.

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA.

Before the prophylactic use of anti-D antibodies in pregnancy, hemolytic anemia of the newborn was the most common cause of hyperbilirubinemia. Nowadays, given the rarity of hemolytic anemia of the newborn, hepatobiliary abnormalities, perinatal infections, and metabolic disorders have become the most common conditions in the differential diagnosis of neonatal cholestasis. Here, we report 3 instances of cholestatic giant cell hepatitis in 3 infants who had Coombs' positive hemolysis due to ABO incompatibility in 1, Rh incompatibility in another, and combined ABO and Rh incompatibility in the third. Read More

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Molecular red cell genotyping of rare blood donors in South Africa to enhance rare donor-patient blood matching.

Afr J Lab Med 2021 27;10(1):1400. Epub 2021 Sep 27.

Medical Department, Specialised Laboratory Services, South African National Blood Service, Durban, South Africa.

Background: Molecular red cell genotyping is devoid of serology limitations such as the scarcity of rare antisera and the possibility of inconclusive results due to biological interferences. Blood incompatibility can result in immune transfusion reactions such as haemolytic transfusion reactions or haemolytic disease of the foetus and newborn.

Objective: The study aimed to use molecular red cell genotyping to identify rare blood group donors among South African blood donors. Read More

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September 2021

Hemolytic Disease of the Newborn: A Review of Current Trends and Prospects.

Pediatric Health Med Ther 2021 7;12:491-498. Epub 2021 Oct 7.

Preventive Medicine and Public Health, Ministry of Health, Makkah City, Kingdom of Saudi-Arabia.

Hemolytic disease of the newborn (HDN), also known as , is a hemolytic condition that predominantly affects rhesus-positive fetuses and infants born to rhesus-negative mothers. The pathophysiology of HDN begins with maternal antibodies attacking fetal red blood cells following alloimmunization due to rhesus or ABO incompatibility between the maternal and fetal blood. Previously, HDN was known to cause fetal death in 1% of all pregnancies, but with the advent of immunoprophylactic therapies, the condition can be currently fairly well managed with fewer complications if diagnosed early. Read More

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October 2021

Transcranial direct current stimulation for provoked vestibulodynia: What roles do psychosexual factors play in treatment response?

J Clin Neurosci 2021 Nov 11;93:54-60. Epub 2021 Sep 11.

School of Rehabilitation, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12th Avenue North, Sherbrooke, Québec J1H 5N4, Canada. Electronic address:

There is growing evidence that provoked vestibulodynia (PVD), a frequent and debilitating condition, is characterized by central sensitization. This study aimed to examine predictive factors of transcranial direct current stimulation (tDCS) efficacy in this chronic pain population. Exploratory analysis derived from a randomized controlled trial was performed to assess predictors of pain reduction among 39 women with PVD who received 10 daily sessions of either active or sham tDCS. Read More

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November 2021

The Spectrum of Hemolytic Disease of the Newborn: Evaluating the Etiology of Unconjugated Hyperbilirubinemia Among Neonates Pertinent to Immunohematological Workup.

Cureus 2021 Aug 6;13(8):e16940. Epub 2021 Aug 6.

Department of Transfusion Medicine, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.

Background and objective The exact burden of hemolytic disease of the newborn (HDN) attributed to neonatal unconjugated hyperbilirubinemia (NUH) in developing nations is still unclear. Still, anti-D is reported to be the most common cause of HDN in India. ABO incompatibility has emerged as a leading cause of exchange transfusion (ET) in many countries. Read More

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Work with cancer or stop working after diagnosis? Variables affecting the decision.

Work 2021 ;70(1):177-185

European Institute of Oncology (IEO), Milan, Italy.

Background: Studies about work and cancer predominantly considered the return to work of cancer survivors. However, some studies highlighted that many patients work with cancer even immediately after the diagnosis. Little is known about the frequency, causes, and consequences of this behavior. Read More

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October 2021

Anterior Cruciate Ligament Injury and its Rehabilitation in Nepal.

JNMA J Nepal Med Assoc 2021 Jul 30;59(239):730-733. Epub 2021 Jul 30.

Orthoplast Rehabilitation and Sports Centre, Gwarko, Kathmandu, Nepal.

Anterior cruciate ligament is one of the most common ligaments to get injured especially in athletic population. It is a band of dense connective tissue which arises from the antero-medial aspect of the inter condylar area on the tibial plateau and passes upwards and backwards to attach to the posteromedial aspect of the lateral femoral condyle. There is increasing rate of its reported injuries among athletes in Nepal and surgeons report increased consultations among athletes regarding adequate intervention strategies. Read More

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Hemolytic Disease of Newborn: Beyond Rh-D and ABO Incompatibility.

Indian Pediatr 2021 Aug;58(8):794-795

Department of Neonatology, Indira Gandhi Institute of Child Health, Bangalore, Karnataka.

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Non-immune hydrops fetalis: Two case reports.

World J Clin Cases 2021 Aug;9(22):6531-6537

Fetal Medicine and Prenatal Diagnosis Unit, Villa Sofia Cervello Hospitals, Palermo 90146, Italy.

Background: Fetal hydrops is a serious condition difficult to manage, often with a poor prognosis, and it is characterized by the collection of fluid in the extravascular compartments. Before 1968, the most frequent cause was the maternal-fetal Rh incompatibility. Today, 90% of the cases are non-immune hydrops fetalis. Read More

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A window of opportunity: systems thinking for prevention of haemolytic disease of the fetus and newborn with transfusion policy.

Authors:
Meghan Delaney

Br J Haematol 2021 11 16;195(4):487-489. Epub 2021 Aug 16.

Children's National Hospital &, The George Washington University School of Health Sciences, Washington, DC, USA.

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November 2021

Noninvasive Fetal RhD Blood Group Genotyping: A Systematic Review of Economic Evaluations.

J Obstet Gynaecol Can 2021 Dec 11;43(12):1416-1425.e5. Epub 2021 Aug 11.

Ontario Health (Health Technology Assessment, Clinical Institutes and Quality Programs), Toronto, ON.

Objective: Noninvasive fetal rhesus D (RhD) blood group genotyping may prevent unnecessary use of anti-D immunoglobulin (RhIG) in non-alloimmunized RhD-negative pregnancies and can guide management of alloimmunized pregnancies. We conducted a systematic review of the economic literature to determine the cost-effectiveness of this intervention over usual care.

Data Sources: Systematic literature searches of bibliographic databases (Ovid MEDLINE, Embase, and Cochrane) until February 26, 2019, and auto-alerts until October 30, 2020, and of grey literature sources were performed to retrieve all English-language studies. Read More

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December 2021

[Investigation and Analysis of Non-ABO Hemolytic Disease of the Newborn].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Aug;29(4):1330-1333

Department of Clinical Laboratory, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China,E-mail:

Objective: To study the serological detection characteristics and antibody specific distribution of hemolytic disease of the newborn (HDN) caused by irregular antibodies through retrospective case analysis.

Methods: A total of 3 047 suspected cases of HDN were submitted by the Neonatal Department of our hospital from January 2014 to December 2019. Non ABO-HDN cases confirmed in our laboratory were taken as the research objects, while some cases of ABO-HDN were randomly selected as control. Read More

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The effect of extended c, E and K matching in females under 45 years of age on the incidence of transfusion-induced red blood cell alloimmunisation.

Br J Haematol 2021 11 3;195(4):604-611. Epub 2021 Aug 3.

Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands.

Maternal alloantibodies directed against fetal red blood cell (RBC) antigens may cause potentially life-threatening haemolytic disease of the fetus and newborn (HDFN). Dutch transfusion guidelines therefore prescribe preventive cEK matching for all (pre-)fertile females. To quantify the impact of cEK matching, we compared overall and antigen-specific cumulative RBC alloimmunisation incidences in females and males aged <45 years. Read More

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November 2021

Exchange Transfusion for Hyperbilirubinemia among Term and Near Term in NICU of a Tertiary Care Hospital of Bangladesh: Findings from a Prospective Study.

Euroasian J Hepatogastroenterol 2021 Jan-Jun;11(1):21-26

Department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Background: Exchange transfusion in newborns is recommended as emergency management of hyperbilirubinemia to prevent bilirubin encephalopathy and kernicterus.

Aim: This study aimed to determine the frequency and document common side effects of exchange transfusion and outcomes of newborns requiring exchange transfusion.

Materials And Methods: This prospective study was done in the Neonatal Intensive Care Unit (NICU) of Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh, from January 2016 to December 2019. Read More

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A nonS-locus F-box gene breaks self-incompatibility in diploid potatoes.

Nat Commun 2021 07 6;12(1):4142. Epub 2021 Jul 6.

Key Laboratory for Potato Biology of Yunnan Province, The CAAS-YNNU-YINMORE Joint Academy of Potato Science, Yunnan Normal University, Kunming, China.

Potato is the third most important staple food crop. To address challenges associated with global food security, a hybrid potato breeding system, aimed at converting potato from a tuber-propagated tetraploid crop into a seed-propagated diploid crop through crossing inbred lines, is under development. However, given that most diploid potatoes are self-incompatible, this represents a major obstacle which needs to be addressed in order to develop inbred lines. Read More

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Different Types of Minor Blood Group Incompatibility Causing Haemolytic Disease of Neonates in one of the National Children's Medical Centre in China.

J Blood Med 2021 25;12:497-504. Epub 2021 Jun 25.

Neonatal Department, Children's Hospital of Fudan University, Shanghai, 201102, People's Republic of China.

Purpose: To review the neonatal cases with different types of minor blood group incompatible haemolytic diseases in China, and to improve the clinical understanding and management.

Materials And Methods: Seven cases from January, 1st, 2013 to December 31st, 2019 were searched out and reviewed retrospectively. All clinical data and laboratory findings were collected. Read More

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Neonatal Hyperbilirubinemia treatment by Locally Made Low-Cost Phototherapy Units.

Ethiop J Health Sci 2021 Jan;31(1):55-62

Medical Center of the University of Munich (LMU), Germany.

Background: Hyperbilirubinemia is a very common finding in neonates and may occasionally cause severe morbidity and even mortality. Severe hyperbilirubinemia is typically treated, either with phototherapy or exchange transfusions. This study assessed the effectiveness of a locally manufactured phototherapy device for reducing serum bilirubin in neonates with severe hyperbilirubinemia. Read More

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January 2021

Recommendation for validation and quality assurance of non-invasive prenatal testing for foetal blood groups and implications for IVD risk classification according to EU regulations.

Vox Sang 2022 Feb 21;117(2):157-165. Epub 2021 Jun 21.

Department of Transfusion Medicine, University Medical Center Göttingen, Göttingen, Germany.

Background And Objectives: Non-invasive assays for predicting foetal blood group status in pregnancy serve as valuable clinical tools in the management of pregnancies at risk of detrimental consequences due to blood group antigen incompatibility. To secure clinical applicability, assays for non-invasive prenatal testing of foetal blood groups need to follow strict rules for validation and quality assurance. Here, we present a multi-national position paper with specific recommendations for validation and quality assurance for such assays and discuss their risk classification according to EU regulations. Read More

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February 2022

Evaluation of Extended-Wear Hearing Aids as a Solution for Intermittently Noise-Exposed Listeners With Hearing Loss.

Ear Hear 2021 Nov-Dec 01;42(6):1544-1559

Audiology and Speech Pathology Center, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Objectives: Many individuals with noise-related hearing loss continue working in environments where they are periodically exposed to high levels of noise, which increases their risk for further hearing loss. These individuals often must remove their hearing aids in operational environments because of incompatibility with the mandated personal protective equipment, thus reducing situational awareness. Extended-wear hearing aids might provide a solution for these individuals because they can be worn for weeks or months at a time, protect users from high-level noise exposures, and are compatible with communication headsets, earmuffs, and other types of personal protective equipment. Read More

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Direct antiglobulin test in the prediction of hyperbilirubinemia and predischarge bilirubin levels in infants with mother-infant blood type incompatibility.

Pediatr Neonatol 2021 07 22;62(4):406-411. Epub 2021 Apr 22.

Department of Pediatrics, Robert Wood Johnson Medical School - Rutgers University, New Brunswick, NJ 08903, USA. Electronic address:

Background: This research evaluated the association between the mother-infant blood type or rhesus (ABO or Rh) incompatibility, the pattern of neonatal jaundice, and serum bilirubin (TSB) values obtained prior to discharge from hospital of healthy born neonates with gestational age >34 weeks and birth weight >2000 g.

Methods: We utilized a laboratory and neonatal database to identify the cord blood ABO/Rh and direct antiglobulin test (DAT) and TSB measured during hospitalization and re-admission with hyperbilirubinemia for phototherapy treatment. We used hour-specific TSB to analyze the TSB levels for ABO/Rh compatibility and isoimmunization using chi-square, analysis of variance, and regression models. Read More

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Blood group genotyping in alloimmunized multi-transfused thalassemia patients from Iran.

Mol Genet Genomic Med 2021 07 8;9(7):e1701. Epub 2021 May 8.

Blood transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.

Objectives: Serological methods may not be reliable for RBC antigen typing, especially in multi-transfused patients. The blood group systems provoking the most severe transfusion reactions are mainly Rh, Kell, Kidd, and Duffy. We intended to determine the genotype of these blood group system antigens among Iranian alloimmunized thalassemia patients using molecular methods and compare the results with serological phenotyping. Read More

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Prevalence of Rhesus D negativity among reproductive age women in Southern Ethiopia: a cross-sectional study.

BMC Womens Health 2021 04 19;21(1):161. Epub 2021 Apr 19.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Background: The Rhesus (Rh) blood group system is the next most clinically significant blood group system following the ABO blood group. Rh D-negative women are at risk of alloimmunization following exposure to Rh D-positive blood. The exposure of Rh D-negative women to Rh D-positive fetal blood may cause hemolytic disease of the fetus or new-born due to Rh incompatibility. Read More

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Nucleated red blood cell levels in the diagnosis of patients with indirect hyperbilirubinemia.

Minerva Pediatr (Torino) 2021 Apr 15. Epub 2021 Apr 15.

Neonatal Intensive Care Unit, Ankara Training and Research Hospital, Ankara, Turkey -

Background: Nucleated red blood cells (NRBCs) are progenitores of red blood cells that are physiologically seen in the peripheral blood of the fetus and newborn at birth. The increased numbers of NRBCs in the circulation is associated with pathologic conditions such as prematurity, hemolytic diseases and bleeding, intrauterine growth restriction. We aimed to evaluate the relationship between NRBCs and the demographic and clinical characteristics of the patients with indirect hyperbilirubinemia who were followed up in the neonatal intensive care unit. Read More

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Design, implementation, and assessment of an interactive simulation to teach undergraduate immunology students hemolytic disease of the newborn.

Adv Physiol Educ 2021 Jun;45(2):299-306

Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.

Hemolytic disease of the newborn (HDN) is a potentially fatal condition caused by a Rhesus (Rh) antigen incompatibility between a mother and fetus. As a result, determining the Rh status of expectant parents is a routine clinical assessment. Both the physiological and immunological basis of this condition are taught to undergraduate students. Read More

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Developing a databank for multiple transfusion patients: Rh antigen and phenotype distribution among 3000 regular blood donors in Iran.

Transfus Apher Sci 2021 Jun 2;60(3):103124. Epub 2021 Apr 2.

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. Electronic address:

Background: Rhesus (Rh) blood group system is clinically the most significant protein-based grouping system. The Rh system is of vital importance in blood transfusion, and incompatibility between the donor and recipient leads to alloimmunization. Alloimmunization is commonly seen in multiple-transfusion recipients (e. Read More

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Critical analysis of two cases of major crossmatch incompatibility in tertiary care hospital in Delhi.

Asian J Transfus Sci 2020 Jul-Dec;14(2):192-194. Epub 2020 Dec 19.

Department of Pathology, Lady Hardinge Medical College, New Delhi, India.

Rh blood group is one of the most complexes of the human blood groups system. RHD gene encodes the D antigen, and the RHCE encodes the C, c, E, and e antigens. Out of these, Rh D antigen is the most immunogenic while e antigen is the least immunogenic. Read More

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December 2020