2,199 results match your criteria Rh Incompatibility


Pregnancy Outcomes Of Consanguinity Among Antenatal Patients Attending Combined Military Hospital Quetta, Pakistan.

J Ayub Med Coll Abbottabad 2018 Jul-Sep;30(3):423-427

Combined Military Hospital Quetta, Pakistan.

Background: All definitions of consanguinity encompass the basic concept of close blood relation. Highest rates of consanguineous unions are observed for North and Sub Saharan Africa, Middle East, and west, central and south Asia, where 20-50% marriages are consanguineous. In Pakistan, we can hardly find any rigorous research on the pregnancy outcomes of consanguinity except those conducted by Allan Bittles. Read More

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January 2019
9 Reads

Biocatalyst-artificial metalloenzyme cascade based on alcohol dehydrogenase.

Chem Sci 2018 Oct 14;9(38):7447-7454. Epub 2018 Aug 14.

Faculty of Engineering , University of Nottingham , University Park, NG7 2RD , Nottingham , UK . Email:

Chemo-enzymatic cascades of enzymes with transition metal catalysts can offer efficient synthetic strategies, but their development is challenging due to the incompatibility between proteins and transition metal complexes. Rhodium catalysts can be combined with alcohol dehydrogenases to regenerate nicotinamide cofactors using formate as the hydride donor. However, their use is limited, due to binding of the metals to residues on the enzyme surface, leading to mutual enzyme and catalyst inactivation. Read More

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http://xlink.rsc.org/?DOI=C8SC02371A
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http://dx.doi.org/10.1039/c8sc02371aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180310PMC
October 2018
15 Reads

Somatic mosaicisms of chromosome 1 at two different stages of ontogenetic development detected by Rh blood group discrepancies.

Haematologica 2018 Sep 20. Epub 2018 Sep 20.

Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna;

Spontaneous Rh blood group changes are a striking sign, reported to occur preferably in patients with hematological disorders. Upon routine blood grouping, two unrelated individuals showed unexplained mixed red cell phenotype regarding the highly immunogenic c antigen (RH4) clinically relevant for blood transfusion and fetomaternal incompatibility. About half of their red cells were c-positive, whereas the other half was c-negative. Read More

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http://dx.doi.org/10.3324/haematol.2018.201293DOI Listing
September 2018
3 Reads

Impact of Red Blood Cell Antigen Matching on Alloimmunization and Transfusion Complications in Patients with Sickle Cell Disease: A Systematic Review.

Transfus Med Rev 2019 01 26;33(1):12-23. Epub 2018 Jul 26.

Department of Hematology & Oncology, Emory University School of Medicine, Atlanta, GA.

Red blood cells (RBC) transfusion is critical in managing acute and chronic complications in sickle cell disease (SCD); however, it is complicated by RBC alloimmunization, iron overload, transfusion reactions and infection. Several reports documented an increased incidence of alloantibodies in transfused individuals with SCD, especially for Rh and Kell antigens. As a result, the National Institutes of Health Expert Panel and British Society for Haematology guidelines recommend primary matching for C/c, E/e and K antigens in addition to ABO/RhD for RBC transfusions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08877963183004
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http://dx.doi.org/10.1016/j.tmrv.2018.07.003DOI Listing
January 2019
21 Reads

Is Cord Blood Bilirubin Level a Reliable Predictor for Developing Significant Hyperbilirubinemia?

Am J Perinatol 2019 Feb 6;36(3):317-321. Epub 2018 Aug 6.

Department of Pediatrics, Gaziosmanpasa Taksim Research and Training Hospital, Istanbul, Turkey.

Objective:  We aimed to investigate whether cord blood bilirubin (CBB) level could be used to identify the newborns at a high risk of developing hyperbilirubinemia.

Study Design:  Total and direct serum bilirubin level were evaluated from umbilical cord blood of newborns. We checked blood groups and Rh status of all mothers and determined blood groups and direct Coombs test (DC) of newborns born to mothers whose blood group was O type or Rh negative to determine the maternal-fetal blood group or Rh incompatibility. Read More

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http://dx.doi.org/10.1055/s-0038-1667368DOI Listing
February 2019
7 Reads

B/L Basal Ganglia Lesions in a Child Leading to a Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency.

Ann Neurosci 2018 Apr 21;25(1):50-52. Epub 2017 Nov 21.

Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.

Bilateral basal ganglia lesions are a common non-specific finding seen in many diseases. One of the differential diagnoses for it, in a child, is kernicterus occurring due to hyperbilirubinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of severe hyperbilirubinemia. Read More

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https://www.karger.com/Article/FullText/481907
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http://dx.doi.org/10.1159/000481907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981589PMC
April 2018
13 Reads

A new biosensor for noninvasive determination of fetal RHD status in maternal blood of RhD negative pregnant women.

PLoS One 2018 6;13(6):e0197855. Epub 2018 Jun 6.

Department of Medical Biochemistry, Faculty of Medicine, University of Cukurova, Adana, Turkey.

Prenatal detection of the fetal RHD status can be useful in the management of RhD incompatibility to identify fetuses at risk of hemolytic disease. Hemolytic disease causes morbidity and mortality of the fetus in the neonatal period. The routine use of antenatal and postnatal anti-D prophylaxis has reduced the incidence of hemolytic disease of the fetus and newborn. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197855PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991352PMC
December 2018
12 Reads

Degradation caused by incompatibility between sodium stearyl fumarate (PRUV) and AZD7986 in the drug product.

J Pharm Biomed Anal 2018 Sep 22;158:82-87. Epub 2018 May 22.

Early Product Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.

During compatibility study of the AZD7986 project, a peak of 3 area% at the tail (RRT 1.03) of the active pharmaceutical ingredient (API) was discovered for all tablets containing sodium stearyl fumarate (PRUV) under humid condition (e.g. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183086
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http://dx.doi.org/10.1016/j.jpba.2018.05.036DOI Listing
September 2018
56 Reads

Umbilical cord blood bilirubins, gestational age, and maternal race predict neonatal hyperbilirubinemia.

PLoS One 2018 1;13(6):e0197888. Epub 2018 Jun 1.

Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California Los Angeles, UCLA Mattel Children's Hospital, Los Angeles, California, United States of America.

Objective: No validated biomarker at birth exists to predict which newborns will develop severe hyperbilirubinemia. This study's primary aim was to build and validate a prediction model for severe hyperbilirubinemia using umbilical cord blood bilirubins (CBB) and risk factors at birth in neonates at risk for maternal-fetal blood group incompatibility. This study's secondary aim was to compare the accuracy of CBB to the direct antigen titer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197888PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983417PMC
December 2018
3 Reads

UV/O3 treatment as a surface modification of rice husk towards preparation of novel biocomposites.

PLoS One 2018 30;13(5):e0197345. Epub 2018 May 30.

School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.

The use of rice husks (RH) to reinforce polymers in biocomposites are increasing tremendously. However, the incompatibility between the hydrophilic RH fibers and the hydrophobic thermoplastic matrices leads to unsatisfactory biocomposites. Surface modification of the fiber surface was carried out to improve the adhesion between fiber and matrix. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197345PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976143PMC
December 2018
1 Read

Learning from claims: hyperbilirubinaemia and kernicterus.

Arch Dis Child Fetal Neonatal Ed 2019 Mar 25;104(2):F202-F204. Epub 2018 May 25.

Maternity and Newborn, NHS Improvement, London, UK.

We examined claims made against the National Health Service (NHS) involving neonatal jaundice in order to determine whether there were lessons that could be learnt from common themes.This was a retrospective anonymised study using information from the NHS Resolution database for 2001-2011.Twenty cases (16 males) had sufficient information for analysis. Read More

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http://dx.doi.org/10.1136/archdischild-2017-314622DOI Listing
March 2019
8 Reads

[Clinical analysis of seven cases of rare hemolytic disease of the newborn].

Zhonghua Er Ke Za Zhi 2018 May;56(5):369-372

Department of Neonatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To summarize the clinical features of 7 rare cases of hemolytic disease of newborn (HDN), and to improve the understanding of rare HDN. Data of clinical information, laboratory findings, treatments and outcomes were collected and analyzed for four cases with HDN due to anti-M, two cases due to anti-Kidd, and one case due to anti-Duffy. All of them were admitted to the Department of Neonatology, Beijing Children's Hospital Affiliated to Capital Medial University from July 2007 to June 2017. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.05.012DOI Listing

Feminine identity and functional benefits are key factors in women's decision making about upper limb prostheses: a case series.

Disabil Rehabil Assist Technol 2018 May 9:1-15. Epub 2018 May 9.

b Ocean State Research Institute Research , Providence , RI , USA.

Purpose: Although the DEKA Arm promises new abilities, it is unclear if women with upper limb amputation are willing to avail themselves of this new technology. The study purpose was to understand key factors and tradeoffs that shape women's attitudes towards the DEKA Arm.

Methods: This case series includes three women with transradial amputation. Read More

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http://dx.doi.org/10.1080/17483107.2018.1467973DOI Listing
May 2018
3 Reads

Transfusion policy in allogeneic hematopoietic stem cell transplantation.

Authors:
Pervin Topcuoglu

Transfus Apher Sci 2018 Apr 18;57(2):174-177. Epub 2018 Apr 18.

Ankara University, School of Medicine, Turkey. Electronic address:

The incompatibility of ABO blood group between the recipient and the donor is not a barrier to perform allogeneic hematopoietic stem cell transplantation (Allo-HSCT). However, ABO incompatibility may lead to many complications during and after stem cell transplantation at the early or late period. Therefore, the typing of the blood group of the recipient and the donor should be done prior to the transplantation. Read More

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http://dx.doi.org/10.1016/j.transci.2018.04.017DOI Listing
April 2018
6 Reads

Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.

EMBO Mol Med 2018 06;10(6)

School of Biochemistry, University of Bristol, Bristol, UK

Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle-cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level of minor blood group antigens. We use CRISPR-mediated genome editing of an immortalised human erythroblast cell line (BEL-A) to generate multiple enucleation competent cell lines deficient in individual blood groups. Read More

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http://dx.doi.org/10.15252/emmm.201708454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991592PMC
June 2018
6 Reads
8.660 Impact Factor

ABO incompatibility and RhIG immunoprophylaxis protect against non-D alloimmunization by pregnancy.

Transfusion 2018 07 6;58(7):1611-1617. Epub 2018 Apr 6.

Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam.

Background: Hemolytic disease of the fetus and newborn (HDFN) is caused by maternal antibodies against fetal red blood cell antigens, most often anti-D, -K, or -c. ABO incompatibility between mother and child and anti-D immunoprophylaxis (RhIG) are known to reduce the risk of D immunization and subsequent HDFN. However, no immunoprophylaxis has been developed to prevent non-D immunizations. Read More

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http://dx.doi.org/10.1111/trf.14606DOI Listing
July 2018
24 Reads

An approach to incompatible cross-matched red cells: Our experience in a major regional blood transfusion center at Kolkata, Eastern India.

Asian J Transfus Sci 2018 Jan-Jun;12(1):51-56

Department of Immunohaematology and Blood Transfusion, Kolkata Medical College, Kolkata, West Bengal, India.

Introduction: With the increased utilization of immunohematology (IH) analyzers in the transfusion medicine, type, and screen policy is the method of choice. Still, the importance of routine crossmatching could not be overruled. Here, we tried to understand the clinical conditions and safety of red cell transfusion and their outcomes. Read More

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http://dx.doi.org/10.4103/ajts.AJTS_157_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850698PMC

Maternal-fetal Rhesus (Rh) factor incompatibility in Arar, northern Saudi Arabia.

Electron Physician 2017 Dec 25;9(12):5908-5913. Epub 2017 Dec 25.

Intern, Faculty of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia.

Background And Aim: Rh isoimmunization still contributes to the neonatal morbidity and mortality due to non-immunization, under-immunization, and in rare cases, false Rh typing. The main objective of this study was to determine the prevalence of Rh incompatibility, mothers' knowledge about Rh incompatibility, mothers' knowledge about anti-D immunoglobulin and to show the pregnancy outcome of Rh negative mothers.

Methods: A cross-sectional study was carried out at the Maternity and Children Hospital in Arar city from November 2016 to May 2017. Read More

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http://www.ephysician.ir/index.php/browse-issues/2017/12/903
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http://dx.doi.org/10.19082/5908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843415PMC
December 2017
9 Reads

Immunoglobulin for alloimmune hemolytic disease in neonates.

Cochrane Database Syst Rev 2018 03 18;3:CD003313. Epub 2018 Mar 18.

Department of Obstetrics, Leiden University Medical Center, Leiden, Netherlands.

Background: Exchange transfusion and phototherapy have traditionally been used to treat jaundice and avoid the associated neurological complications. Because of the risks and burdens of exchange transfusion, intravenous immunoglobulin (IVIg) has been suggested as an alternative therapy for alloimmune hemolytic disease of the newborn (HDN) to reduce the need for exchange transfusion.

Objectives: To assess the effect and complications of IVIg in newborn infants with alloimmune HDN on the need for and number of exchange transfusions. Read More

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http://dx.doi.org/10.1002/14651858.CD003313.pub2DOI Listing
March 2018
30 Reads

Is the management of Rh-Rh incompatibility with noninvasive fetal Rh genotyping for targeted prophylaxis cost-effective in the Turkish population?

Turk J Med Sci 2018 Feb 23;48(1):1-4. Epub 2018 Feb 23.

Background/aim: The aim of this study was to assess unnecessary immunization rates and compare the cost-effectiveness of targeted prophylaxis with fetal Rh genotyping with that of traditional management of Rh-Rh incompatibility in a virtual economic model. Materials and methods: This retrospective data analysis was conducted at two tertiary centers between 2011 and 2015. The data of 1135 pregnant women were analyzed. Read More

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http://dx.doi.org/10.3906/sag-1511-87DOI Listing
February 2018
3 Reads

Evaluation of Risk Factors for Exchange Range Hyperbilirubinemia and Neurotoxicity in Neonates from Hilly Terrain of India.

Int J Appl Basic Med Res 2017 Oct-Dec;7(4):228-232

Department of Pediatrics, Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India.

Background And Aim: Neonatal hyperbilirubinemia continues to be the most common cause of hospital admissions and readmissions in the neonatal population worldwide and this pattern continues despite attempts to identify neonates at risk of pathological hyperbilirubinemia. Therefore, this study aimed to study the risk factors for severe hyperbilirubinemia in neonates.

Materials And Methods: An observational prospective study was undertaken for 1 year in neonates with hyperbilirubinemia requiring double volume exchange transfusion in neonatology unit of a tertiary rural health care hospital. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_298_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752806PMC
January 2018
5 Reads

Do triple test results predict risk for neonatal hyperbilirubinemia?

Pak J Med Sci 2017 Jul-Aug;33(4):979-983

Merih Cetinkaya, Assistant Professor, Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

Objective: Neonatal jaundice is the most common condition that requires hospital admission and outpatient follow-up after discharge in neonates. The values of more than 17 mg/dL in term infants are accepted as neonatal significant hyperbilirubinemia. We aimed to define if there is any relationship between second trimester serum markers and neonatal severe hyperbilirubinemia to protect the neonates from its neurological damage. Read More

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http://dx.doi.org/10.12669/pjms.334.12420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648976PMC
October 2017
6 Reads

Hyperbilirubinemia due to minor blood group (anti-E) incompatibility in a newborn: a case report.

Turk Pediatri Ars 2017 Sep 1;52(3):162-164. Epub 2017 Sep 1.

Department of Pediatrics, Division of Neonatology, Ufuk University Faculty of Medicine, Ankara, Turkey.

In addition to Rh and ABO incompatibilities subgroup incompatibilities may rarely play a role among the causes of hemolytic anemia and indirect hyperbilirubinemia in newborns. The most common minor blood group antigens that cause blood incompatibility between the mother and baby are C, c, E, e, Kell, Duffy, Diego, Kidd and MNSs antigens. In this article, a newborn in whom hyperbilirubinemia due to anti-E minor blood group incompatibility developed and was treated with phototherapy succesfully is presented and minor blood group incompatibilities due to anti-E are reviewed. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2017.2658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644583PMC
September 2017
1 Read

Rhesus Alloimunization Occurs After Rh Incompatible Liver Transplantation in Children.

Transplantation 2018 01;102(1):e1

Department of Gastroenterology and Clinical Nutrition, The Royal Children's Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1097/TP.0000000000001976DOI Listing
January 2018
7 Reads

Genotyping to prevent Rh disease: has the time come?

Curr Opin Hematol 2017 Nov;24(6):544-550

aSanquin Research, Department of Experimental Immunohematology bLandsteiner Laboratory, Academic Medical Centre, University of Amsterdam cSanquin Diagnostic Services, Department of Immunohematology Diagnostics, Amsterdam dSanquin Research, Department of Immunohematology and Blood Transfusion, Center for Clinical Transfusion Research, Leiden and Leiden University Medical Center, Leiden, The Netherlands eDepartment of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Purpose Of Review: In this review, we analyzed the current literature on noninvasive fetal RHD typing to answer the question whether the administration of RhIg to prevent D-alloimmunization during pregnancy can be safely guided by fetal RHD typing.

Recent Findings: Recently the first centers that implemented large-scale nationwide fetal RHD typing in the second trimester for targeted RhIg administration have published their studies evaluating the diagnostic accuracy of their screening programs. These data show that fetal RHD typing in a routine setting is, at least in a population of European descent, accurate enough to guide both antenatal and postnatal immunoprophylaxis. Read More

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http://Insights.ovid.com/crossref?an=00062752-201711000-0001
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http://dx.doi.org/10.1097/MOH.0000000000000379DOI Listing
November 2017
25 Reads

[Anti-D prophylaxis in fetal-maternal erythrocyte incompatibility in Tunisia].

Arch Pediatr 2017 Oct;24(10):942-949

Service de médicine et de réanimation néonatale, centre de maternité et de néonatologie de Tunis (CMNT), faculté de médicine de Tunis, université Tunis-El-Manar, Tunis, Tunisie.

Generalization of postnatal prophylaxis using anti-D immunoglobulins decreased the incidence of erythrocyte fetal-maternal incompatibility (EFMI) in the Rhesus system. Few recent studies have investigated the situation of anti-D prophylaxis in Tunisia and its effects on maternal and neonatal health. The aim of this study was therefore to analyze the situation of anti-D prophylaxis in Tunisia to detect defects and propose solutions. Read More

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http://dx.doi.org/10.1016/j.arcped.2017.07.007DOI Listing
October 2017

An international investigation into O red blood cell unit administration in hospitals: the GRoup O Utilization Patterns (GROUP) study.

Transfusion 2017 10 25;57(10):2329-2337. Epub 2017 Aug 25.

University of Pittsburgh and the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania.

Background: Transfusion of group O blood to non-O recipients, or transfusion of D- blood to D+ recipients, can result in shortages of group O or D- blood, respectively. This study investigated RBC utilization patterns at hospitals around the world and explored the context and policies that guide ABO blood group and D type selection practices.

Study Design And Methods: This was a retrospective study on transfusion data from the 2013 calendar year. Read More

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http://dx.doi.org/10.1111/trf.14255DOI Listing
October 2017
27 Reads

Red blood cell minor antigen mismatches during chronic transfusion therapy for sickle cell anemia.

Transfusion 2017 11 24;57(11):2738-2746. Epub 2017 Aug 24.

Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.

Background: Red blood cell (RBC) alloimmunization occurs at a high frequency in sickle cell anemia (SCA) despite serologic matching for Rh (C/c, E/e) and K antigens. RBC minor antigen genotyping allows for prediction of antigens and RH variants that may lead to alloimmunization.

Study Design And Methods: RBC antigen genotyping was performed on chronically transfused pediatric SCA patients, using PreciseType human erythrocyte antigen (HEA), RHCE, and RHD BeadChip arrays. Read More

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http://dx.doi.org/10.1111/trf.14282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673534PMC
November 2017
28 Reads

[Blood Transfusion Selection in Patients with Autoimmune Hemolytic Anemia Producing Class Antibodies].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2017 Aug;25(4):1208-1211

Department of Blood Transfusion, The First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province, China. E-mail:

Objective: To analyze the reasons for the incompatibility of cross matching in lymphoma patients complicated by autoimmune hemolytic anemia (AIHA), and to provide compatible blood to patients for multiple blood transfusion.

Methods: The test tube method was used for routine identification of ABO blood group, Rh typing and direct anti-globulin test; the patients antibody was identified by saline water method, micro column gel card; and the saline water method, Polybrene method and antiglobulin method were used for blood cross matching test of the patients.

Results: In the serum of the patient, positive autoantibodies were detected, in the elution, the Ce antibody was detected. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2017.04.043DOI Listing
August 2017
21 Reads

Alloimmune hemolysis due to major RhE incompatibility after unrelated cord blood transplantation.

Leuk Lymphoma 2018 04 20;59(4):1000-1003. Epub 2017 Jul 20.

a Department of Hematology/Oncology , The Institute of Medical Science, The University of Tokyo , Tokyo , Japan.

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http://dx.doi.org/10.1080/10428194.2017.1352095DOI Listing
April 2018
7 Reads

Enhanced opsonisation of Rhesus D-positive human red blood cells by recombinant polymeric immunoglobulin G anti-G antibodies.

Blood Transfus 2018 02 30;16(2):200-208. Epub 2017 May 30.

Cellular and Molecular Pathology Laboratory, Experimental Medicine Centre, Venezuelan Institute of Scientific Investigation (IVIC), Caracas, Venezuela.

Background: Anti-RhD antibodies (anti-D) are important in the prophylaxis of haemolytic disease of the foetus and newborn (HDFN) due to RhD incompatibility. Current preparations of anti-D are sourced from hyperimmune human plasma, so its production carries a risk of disease and is dependent on donor availability. Despite the efforts to develop a monoclonal preparation with similar prophylactic properties to the plasma-derived anti-D, no such antibody is yet available. Read More

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http://dx.doi.org/10.2450/2017.0176-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839618PMC
February 2018
26 Reads

Medical and economic implications of strategies to prevent alloimmunization in sickle cell disease.

Transfusion 2017 09 26;57(9):2267-2276. Epub 2017 Jun 26.

Department of Pathology, Johns Hopkins University, Baltimore, Maryland.

Background: The pathogenesis of alloimmunization is not well understood, and initiatives that aim to reduce the incidence of alloimmunization are generally expensive and either ineffective or unproven. In this review, we summarize the current medical literature regarding alloimmunization in the sickle cell disease (SCD) population, with a special focus on the financial implications of different approaches to prevent alloimmunization.

Study Design And Methods: A review of EMBASE and MEDLINE data from January 2006 through January 2016 was conducted to identify articles relating to complications of SCD. Read More

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http://dx.doi.org/10.1111/trf.14212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695925PMC
September 2017
6 Reads

NGS and blood group systems: State of the art and perspectives.

Authors:
Y Fichou C Férec

Transfus Clin Biol 2017 Sep 21;24(3):240-244. Epub 2017 Jun 21.

Établissement français du sang Bretagne, 46 rue Félix-Le-Dantec, CS 51819, 29218 Brest cedex 2, France; Institut national de la santé et de la recherche médicale (Inserm), UMR1078, Brest, France; Laboratoire de génétique moléculaire et d'histocompatibilité, centre hospitalier régional universitaire (CHRU), hôpital Morvan, Brest, France; Faculté de médecine et des sciences de la santé, université de Bretagne occidentale (UBO), Brest, France.

Molecular analysis, or genotyping, of genes involved in the expression of blood group antigens has been a standard strategy used in immunohaematology laboratories routinely. For the past ten years, next-generation sequencing (NGS), or second-generation sequencing, has become the reference method in genetics. Extensive study of distinct targets, large genomic regions, and even whole genome is henceforth possible by this approach at minimal cost. Read More

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http://dx.doi.org/10.1016/j.tracli.2017.06.002DOI Listing
September 2017
6 Reads

[Identification of alloantibodies and their associations: Balance sheet of 3 years at the Regional Center of Blood Transfusion in Rabat/Morocco and difficult in transfusion management].

Transfus Clin Biol 2017 Nov 31;24(4):422-430. Epub 2017 May 31.

Centre régional de transfusion sanguine, immuno-hématologie, Bab-El-Irfane, rue M'FadeL-Cherka, 10000 Rabat, Maroc.

Red blood cell immunization can lead to delays or even an impasse in a transfusion.

Objectives: Determine the specificities of the most common of alloantibodies and their associations to correct management of red blood cell transfused.

Methods And Materials: A retrospective study between 2013 and 2015 in immunohematology laboratories at the Blood Transfusion Center of Rabat in Morocco. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12467820173006
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http://dx.doi.org/10.1016/j.tracli.2017.04.006DOI Listing
November 2017
22 Reads

Potential Use of Polyvinyl Acetate-Polyvinylpyrrolidone Mixture for the Development of Atenolol Sustained Release Matrix Tablets: Optimization of Formulation through in Vitro-in Vivo Assessment Study.

Chem Pharm Bull (Tokyo) 2017 ;65(6):545-557

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University.

The objective of this study was to develop sustained release matrix tablets of atenolol (AT) using different concentrations of polyvinyl acetate-polyvinylpyrrolidone mixture (KSR) (20, 30, or 40%) with various types of fillers such as spray dried lactose (SP.D.L), avicel pH 101 (AV), and emcompress (EMS). Read More

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http://dx.doi.org/10.1248/cpb.c17-00028DOI Listing
July 2017
8 Reads

Translation, cross-cultural adaptation, and validation of the Liverpool Oral Rehabilitation Questionnaire (LORQ) into the Dutch language.

J Prosthet Dent 2018 Feb 26;119(2):239-243. Epub 2017 May 26.

Maxillofacial prosthodontist, Centre for Special Oral Care, Radboud University Medical Centre, Nijmegen, The Netherlands.

Statement Of Problem: The Liverpool Oral Rehabilitation Questionnaire (LORQ) is a health-related quality of life instrument assessing the impact of oral rehabilitation on patients' health-related quality of life. Because a validated Dutch version of the LORQ is not available, the questionnaire cannot be used in the Netherlands.

Purpose: The purpose of this study was to translate and adapt the LORQv3 into a Dutch-language version and to evaluate the internal consistency, reliability, and validity of the resulting LORQv3-NL. Read More

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http://dx.doi.org/10.1016/j.prosdent.2017.03.023DOI Listing
February 2018
40 Reads

Incomplete Antibodies May Reduce ABO Cross-Match Incompatibility: A Pilot Study.

Turk J Haematol 2018 Mar 23;35(1):54-60. Epub 2017 May 23.

Ankara University Faculty of Medicine, Department of Hematology, Ankara, Turkey.

Objective: Any erythrocyte transfusion among humans having type A or B blood groups is impossible due to antibodies causing fatal transfusion complications. A cross-match test is performed to prevent immune transfusion complications before transfusion. Our hypothesis is that the fragment antibody (Fab) part of the antibody (incomplete antibody) may be used to prevent an immune stimulus related to the complete antibody. Read More

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http://dx.doi.org/10.4274/tjh.2016.0504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843775PMC
March 2018
16 Reads

A rare, potentially life-threatening presentation of passenger lymphocyte syndrome.

Transfusion 2017 May 28;57(5):1262-1266. Epub 2017 Mar 28.

Department of Pathology, Division of Transfusion Medicine, Johns Hopkins Hospital, Baltimore, Maryland.

Background: Passenger lymphocyte syndrome occurs when donor lymphocytes are transplanted with a solid organ and produce alloantibodies that react with antigens on the recipient's red blood cells (RBCs). Typically, passenger lymphocyte syndrome presents as immunoglobulin G antibody-mediated, extravascular hemolytic anemia with reticulocytosis. Often, the donor was alloimmunized before transplantation. Read More

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http://dx.doi.org/10.1111/trf.14055DOI Listing
May 2017
19 Reads

Molecular insight into atypical instability behavior of fixed-dose combination containing amlodipine besylate and losartan potassium.

J Pharm Biomed Anal 2017 Mar 29;136:66-80. Epub 2016 Dec 29.

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar 160 062, Punjab, India. Electronic address:

Combination therapy with the use of fixed-dose combinations (FDCs) is evincing increasing interest of prescribers, manufacturers and even regulators, evidently due to the primary benefit of improved patient compliance. However, owing to potential of drug-drug interaction, FDCs require closer scrutiny with respect to their physical and chemical stability. Accordingly, the purpose of the present study was to explore stability behavior of a popular antihypertensive combination of amlodipine besylate (AML) and losartan potassium (LST). Read More

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http://dx.doi.org/10.1016/j.jpba.2016.12.035DOI Listing
March 2017
8 Reads

Navigating the journey of Aboriginal childhood disability: a qualitative study of carers' interface with services.

BMC Health Serv Res 2016 12 1;16(1):680. Epub 2016 Dec 1.

University of Technology Sydney, Center for Cardiovascular and Chronic Care, Faculty of Health, PO Box 123, Broadway, Sydney, NSW, 2007, Australia.

Background: The disadvantage experienced by Aboriginal and Torres Strait Islander children with a disability is well recognized. The long term consequences of failing to address disability on health, education and employment underlies the importance of early intervention. Caregivers experience a disproportionate burden and have challenges accessing services. Read More

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http://dx.doi.org/10.1186/s12913-016-1926-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134075PMC
December 2016
72 Reads

Prediction of significant hyperbilirubinemia in term neonates by early non-invasive bilirubin measurement.

World J Pediatr 2017 Jun 23;13(3):222-227. Epub 2016 Nov 23.

Department of Obstetrics & Gynecology, MGIMS, Sevagram, Wardha, Maharashtra, India.

Background: Neonatal jaundice is a common problem. We evaluated the utility and best cut-off values of 24-and 48-hour transcutaneous bilirubin indices (TcBI) in predicting subsequent significant hyperbilirubinemia and evaluated various associated maternal and fetal risk factors.

Methods: TcBI at 24 and 48 hours and serum bilirubin levels at 72 hours of age were obtained for healthy, term, appropriate for gestational age neonates. Read More

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http://dx.doi.org/10.1007/s12519-016-0067-1DOI Listing
June 2017
9 Reads

Circulating Cell-Free DNA to Determine the Fetal RHD Status in All Three Trimesters of Pregnancy.

Obstet Gynecol 2016 12;128(6):1340-1346

Departments of Obstetrics and Gynecology at the Baylor College of Medicine, Houston, Texas; The Ohio State University Wexner Medical Center, Columbus, Ohio; Columbia University Medical Center, New York, New York; the University of North Carolina School of Medicine, Chapel Hill, North Carolina; Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania; Tristate Maternal Fetal Medicine Association, Inc, Cincinnati, Ohio; and the Department of Obstetrics, Gynecology and Reproductive Sciences, Icahn School of Medicine at Mt. Sinai, New York, New York; the Departments of Obstetrics and Gynecology at Wayne State University/Detroit Medical Center, Detroit, Michigan; New York Presbyterian Queens and Weill Cornell Medical College, New York, New York; Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; Evergreen Hospital, Seattle, Washington; Phoenix Perinatal Associates, Phoenix, Arizona; McGill University, Montréal, Quebec, Canada; the University of British Columbia, Vancouver, Canada; Medical University of South Carolina, Charleston, South Carolina; Spectrum Health Hospitals, Grand Rapids, Michigan; William Beaumont Hospital, Royal Oak, Michigan; Drexel University College of Medicine, Philadelphia, Pennsylvania; and Sequenom, Inc, and the Sequenom Center for Molecular Medicine, San Diego, California.

Objective: To estimate the accuracy of a new assay to determine the fetal RHD status using circulating cell-free DNA.

Methods: This was a prospective, observational study. Maternal blood samples were collected in each trimester of pregnancy in 520 nonalloimmunized RhD-negative patients. Read More

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http://dx.doi.org/10.1097/AOG.0000000000001741DOI Listing
December 2016
32 Reads

Diagnostic accuracy of fetal rhesus D genotyping using cell-free fetal DNA during the first trimester of pregnancy.

Am J Obstet Gynecol 2016 Nov 5;215(5):606.e1-606.e5. Epub 2016 Jul 5.

Département de Biologie Spécialisée et de Génétique, Laboratoire CERBA, Saint-Ouen l'Aumône, France. Electronic address:

Background: Rhesus D genotyping with cell-free fetal DNA currently is used throughout the world. Although this technique has spread rapidly, its optimal use is still a matter of debate. This screening test has been introduced mainly for the treatment of RhD-negative pregnant women during the third trimester of pregnancy, thereby avoiding systematic anti-D prophylaxis, yet such a strategy has proved cost-ineffective. Read More

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http://dx.doi.org/10.1016/j.ajog.2016.06.054DOI Listing
November 2016
17 Reads

Development and statistical optimization of nefopam hydrochloride loaded nanospheres for neuropathic pain using Box-Behnken design.

Saudi Pharm J 2016 Sep 25;24(5):588-599. Epub 2015 Mar 25.

Chitkara College of Pharmacy, Chitkara University, Chandigarh Patiala National-Highway (NH-64), Rajpura, Patiala 140401, Punjab, India.

Nefopam hydrochloride (NFH) is a non-opioid centrally acting analgesic drug used to treat chronic condition such as neuropathic pain. In current research, sustained release nefopam hydrochloride loaded nanospheres (NFH-NS) were auspiciously synthesized using binary mixture of eudragit RL 100 and RS 100 with sorbitan monooleate as surfactant by quasi solvent diffusion technique and optimized by 3 Box-Behnken designs to evaluate the effects of process and formulation variables. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetric (DSC) and X-ray diffraction (XRD) affirmed absence of drug-polymer incompatibility and confirmed formation of nanospheres. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13190164150008
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http://dx.doi.org/10.1016/j.jsps.2015.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059834PMC
September 2016
11 Reads

Severe Sepsis After Living Donor Liver Transplantation: Risk Factors and Outcomes.

Transplant Proc 2016 Jul-Aug;48(6):2124-9

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background: The post-operative mortality and morbidity rates associated with living-donor liver transplantation (LDLT) are still relatively high. Several papers have reported the risk factors associated with post-operative infectious complications, but few have analyzed the risk factors with respect to the severity of sepsis. The aim of this study was to clarify the risk factors that affect severe sepsis after LDLT. Read More

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http://dx.doi.org/10.1016/j.transproceed.2016.03.040DOI Listing
April 2017
2 Reads

Flow Cytometry in Detection of Fetal Red Blood Cells and Maternal F Cells to Identify Fetomaternal Hemorrhage.

Fetal Pediatr Pathol 2016 5;35(6):385-391. Epub 2016 Aug 5.

e Department of Obstetrics and Gynecology , Hospital de Clinicas de Porto Alegre , Porto Alegre , Brazil.

Accurate detection and quantitation of fetomaternal hemorrhage (FMH) is critical to the obstetric management of rhesus D alloimmunization in Rh-negative pregnant women. The flow cytometry is based on the detection of fetal red blood cells using a monoclonal anti-HbF antibody, and is the method most indicated for this estimation. The objective of this study was to quantify fetal red blood cell levels of pregnant women using flow cytometry. Read More

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http://dx.doi.org/10.1080/15513815.2016.1209260DOI Listing
February 2018
8 Reads

Hyperbilirubinemia in Neonates: Types, Causes, Clinical Examinations, Preventive Measures and Treatments: A Narrative Review Article.

Iran J Public Health 2016 May;45(5):558-68

Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Iran.

Background: Hyperbilirubinemia, or jaundice, is a life threatening disorder in newborns. It is a multifactorial disorder with many symptoms. Generally, the physiological jaundice is the most prevalent type however in some regions pathological jaundice is also common. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935699PMC
May 2016
50 Reads
1 Citation
0.580 Impact Factor

Hemolytic Disease of the Fetus and Newborn: Modern Practice and Future Investigations.

Transfus Med Rev 2016 10 26;30(4):159-64. Epub 2016 May 26.

Laboratory Medicine, Seattle Children's Hospital, Seattle, WA; Bloodworks NW, Seattle, WA.

Red blood cell (RBC) sensitization occurs in some women in response to exposure to paternally derived RBC antigens during pregnancy or to nonself antigens on transfused RBCs during their lifetime. Once sensitized, future pregnancies may be at risk for hemolytic disease of the fetus and newborn. Although great strides have been made over the past few decades in terms of identifying blood group antigens and in predicting fetal anemia through the use of noninvasive monitoring, many questions remain in terms of understanding RBC alloimmunization risk factors, preventative therapies, and treatment strategies. Read More

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http://dx.doi.org/10.1016/j.tmrv.2016.05.008DOI Listing
October 2016
80 Reads