3,806 results match your criteria Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion[Journal]


CHRONIC OBSTRUCTIVE PULMONARY DISEASE: PERSPECTIVES FOR PRIMARY HEALTH CARE.

Rev Invest Clin 2019 ;71(1):55-63

Department of Research in Tobacco and COPD, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.

Background: Chronic obstructive pulmonary disease (COPD) has become a major health challenge worldwide due to its increasing incidence and mortality, which have serious repercussions for health-care systems.

Methods: We conducted a review of international efforts to control COPD in primary care.

Results: The WHO created the Alma-Ata declaration which established for the first time, access to health care as a human right. Read More

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http://dx.doi.org/10.24875/RIC.18002630DOI Listing
January 2019
6 Reads

SMOKING CESSATION TREATMENTS: CURRENT PSYCHOLOGICAL AND PHARMACOLOGICAL OPTIONS.

Rev Invest Clin 2019 ;71(1):7-16

Smoking Cessation Service, Comunidad Madrid, Spain.

Background: Smoking is considered an epidemic, indeed, one of the most important public health problems worldwide. It is also the most significant preventable cause of death, of a high number of premature deaths, and avoidable chronic diseases. It is considered an enormous economic burden for the world. Read More

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http://dx.doi.org/10.24875/RIC.18002629DOI Listing
January 2019

RESPIRATORY IMPACT OF ELECTRONIC CIGARETTES AND "LOW-RISK" TOBACCO.

Rev Invest Clin 2019 ;71(1):17-27

Department of Tobacco Research, Center for Population Health Research, Instituto Nacional de Salud Pública, Cuernavaca, Mexico.

Electronic cigarettes, handheld devices that generate an aerosol that may contain nicotine by heating a solution or e-liquid, have been increasingly used especially in the young population. The aerosol's composition is determined by temperature, and by the substances contained in the heated liquid: glycerin, propylene glycol, nicotine in variable concentrations, flavoring agents, and other non-nicotine compounds. >80 compounds (including known toxics, e. Read More

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http://dx.doi.org/10.24875/RIC.18002616DOI Listing
January 2019
5 Reads

PREFACE.

Rev Invest Clin 2019 ;71(1):5-6

Research Unit, National Institute of Respiratory Diseases Ismael Cosío Villegas, Mexico City, Mexico.

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January 2019

SMALLa AIRWAY DISEASE IN COPD ASSOCIATED TO BIOMASS EXPOSURE.

Rev Invest Clin 2019 ;71(1):70-78

Department of Respiratory Medicine, Fundación Médica Sur, Mexico City, Mexico.

Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous entity that may result from different causative agents and risk factors and may follow diverse clinical courses, including COPD secondary to biomass smoke exposure. At present, this phenotype is becoming more important for two reasons: first, because at least almost half of the world's population is exposed to biomass smoke, and second, because the possibility of it being diagnosed is increasing. Biomass smoke exposure COPD affects primarily women and is related with insults to the airways occurred during early life. Read More

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http://dx.doi.org/10.24875/RIC.18002652DOI Listing
January 2019
1 Read

CONTROVERSIES AND LIMITATIONS IN THE DIAGNOSIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

Rev Invest Clin 2019 ;71(1):28-35

Department of Research on Tobacco and COPD, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.

Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality worldwide. While the cut-off point to define airflow obstruction has been controversial, it is widely accepted that the spirometry test is vital, as well as performing it after using a bronchodilator. The 6-second spirometry and the forced expiratory volume in 1 second/forced expiratory volume in 6 seconds (FEV/FEV) have demonstrated validity for defining obstruction, and it would be advisable to incorporate them in the definitions of obstruction. Read More

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http://dx.doi.org/10.24875/RIC.18002626DOI Listing
January 2019
2 Reads

ROLE OF GENETIC SUSCEPTIBILITY IN NICOTINE ADDICTION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

Rev Invest Clin 2019 ;71(1):36-54

HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in developed countries. Although cigarette smoking is the major risk factor, only 10-20% of smokers develop COPD. The extent of cigarette smoking (pack-years and smoking duration) accounts for only 15% of the variation in lung function, indicating that differences in susceptibility to COPD must exist. Read More

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http://dx.doi.org/10.24875/RIC.18002617DOI Listing
January 2019

SYMPTOMATIC AND ASYMPTOMATIC SMOKERS WITHOUT AIRFLOW OBSTRUCTION: A NEW CLINICAL ENTITY?

Rev Invest Clin 2019 ;71(1):64-69

Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Padova, Italy.

Non-obstructed ever-smokers, with or without symptoms, have generated a great deal of information recently, but few reviews. Even individuals with normal spirometry can present changes in sputum with inflammatory biomarkers (cellular and molecular) and airways and parenchyma with remodeling; when symptomatic (cough, sputum, wheezing, and dyspnea) exacerbations are frequent affecting the individuals' quality of life, there is an increased use of health resources: more medication, emergency visits, and hospital admissions. Non-obstructed smokers may have exercise limitations, increased lung volumes, low diffusion capacity, air entrapment, peripheral airways obstruction, elevated airways resistance, and abnormal multiple breath nitrogen washout, as well as abnormalities in computed tomography studies, such as airway wall thickening, emphysema, or interstitial lung abnormalities. Read More

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http://dx.doi.org/10.24875/RIC.18002648DOI Listing
January 2019
1 Read

The Effect of Single-Dose Intraperitoneal Bevacizumab on Peritoneal Adhesion Formation.

Rev Invest Clin 2018 ;70(6):279-284

Department of General Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Background: Intra-abdominal adhesions and their complications following abdominal surgery are serious problems, with an incidence of 67-93%. Prevention of peritoneal adhesion formation may eliminate the need for surgical intervention, decreasing complications, morbidity, and cost. Bevacizumab is a recombinant monoclonal antibody which specifically binds vascular endothelial growth factor, an important cytokine in adhesion formation, and neutralizes its biological activity. Read More

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http://dx.doi.org/10.24875/RIC.18002589DOI Listing
April 2019
1 Read

The Role of Stents as Bridge to Surgery for Acute Left-Sided Obstructive Colorectal Cancer: Meta-Analysis of Randomized Controlled Trials.

Rev Invest Clin 2018 ;70(6):269-278

Department of Gastrointestinal Surgery, Eastern Hospital, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China Affiliated Hospital & Sichuan Provincial People's Hospital. Sichuan Province, China.

Background: The role of self-expanding metallic stents (SEMS) as a bridge to surgery for acute left-sided obstructive colorectal cancer has remained controversial.

Objective: To study the efficacy of this approach, we performed a meta-analysis at the gastrointestinal surgery center of Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital (Eastern Hospital).

Methods: Two PubMed and science-direct electronic databases were searched up to December 30, 2017. Read More

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http://dx.doi.org/10.24875/RIC.18002516DOI Listing
April 2019
3 Reads

Integrative View of the Mechanisms that Induce Acute Kidney Injury and its Transition to Chronic Kidney Disease.

Rev Invest Clin 2018 ;70(6):261-268

Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, and Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City, Mexico.

There is ample evidence showing that acute kidney injury (AKI) increases the risk of developing chronic kidney disease (CKD). Although considerable efforts have been undertaken in recent years to elucidate the mechanisms responsible for the AKI to CKD transition, many questions remain to be answered. In this review, we address most of the latest studies elucidating the mechanisms involved in this transition. Read More

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http://dx.doi.org/10.24875/RIC.18002546DOI Listing
April 2019
1 Read

Diagnostic Utility of [11C]DTBZ Positron Emission Tomography In Clinically Uncertain Parkinsonism: Experience of a Single Tertiary Center.

Rev Invest Clin 2018 ;70(6):285-290

Movement Disorders Clinic. Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.

Background: The use of single-photon emission computed tomography and positron emission tomography (PET) has proven to be helpful in differentiating Parkinson's disease (PD) from other movement disorders with a sensitivity of up to 95%.

Objective: The objective of this study was to determine the accuracy of [11C]DTBZ PET imaging in patients with clinically uncertain parkinsonism from a tertiary referral center in Mexico City.

Materials And Methods: Patients who underwent [11C]DTBZ PET brain scan due to clinically uncertain parkinsonism where divided into two groups: PD or non-PD. Read More

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http://dx.doi.org/10.24875/RIC.18002644DOI Listing
April 2019
1 Read

Type 2 Diabetes Mellitus is Associated with Carotid Artery Plaques in Patients with Premature Coronary Heart Disease.

Rev Invest Clin 2018 ;70(6):301-309

Department of Nephrology, Laboratory of Renal Physiopathology. Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Background: In subjects without a history of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) is associated with carotid artery plaques (CAP), which is a better marker than high carotid intima-media thickness (hCIMT) for predicting first or recurrent cardiovascular events.

Objective: The objective of this study is to analyze the association of T2DM with CAP and hCIMT in premature CHD patients.

Methods: Premature CHD was considered before the age of 55 years in men and before 65 in women. Read More

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http://dx.doi.org/10.24875/RIC.18002591DOI Listing
April 2019
2 Reads

Calculated Versus Measured Urine Osmolarity: Accuracy of Estimated Urine Density.

Rev Invest Clin 2018 ;70(6):310-318

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City, México.

Background: Urine osmolarity (OsmU) is the gold standard for the evaluation of the kidney's urine concentration capacity; nevertheless, urinary density (UD) is often used as a surrogate for its estimation.

Objective: The objective of this study was to analyze the accuracy of UD in estimating OsmU.

Materials And Methods: A transversal study including patients with simultaneous determination of UD measured with refractometry and OsmU measured by osmometer (OsmUm). Read More

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http://dx.doi.org/10.24875/RIC.18002598DOI Listing
April 2019
7 Reads

Oncological Implications of Lymph Nodes Retrieval and Perineural Invasion in Colorectal Cancer: Outcomes from a Referral Center.

Rev Invest Clin 2018 ;70(6):291-300

Department of Endocrine Surgery. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: In colorectal cancer (CRC), regional lymphadenectomy provides prognostic information and guides management. The current consensus states that at least 12 lymph nodes (LN) should be evaluated. The aims of this study were to identify whether the number of LN is a predictor for survival and recurrence, and to reveal the role of LN ratio (LNR) and perineural invasion (PNI) in predicting prognosis after curative resection of CRC. Read More

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http://dx.doi.org/10.24875/RIC.18002505DOI Listing
April 2019
1 Read

GENOMICS AND SYSTEMS BIOLOGY APPROACHES IN THE STUDY OF LIPID DISORDERS.

Rev Invest Clin 2018 ;70(5):217-223

Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, USA.

Cardiovascular disease (CVD) is a broad definition for diseases of the heart and blood vessels with high mortality and morbidity worldwide. Atherosclerosis and hypertension are the most common causes of CVD, and multiple factors confer the susceptibility. Some of the predisposing factors are modifiable such as diet, smoking, and exercise, whereas others, including age, sex, and individual's genetic variations contributing to the CVD composition traits, are non-modifiable. Read More

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http://dx.doi.org/10.24875/RIC.18002576DOI Listing
December 2018
20 Reads

NEW BIOTECHNOLOGICAL TREATMENTS FOR LIPID DISORDERS.

Rev Invest Clin 2018 ;70(5):244-254

Department of Medicine, Universidad de los Andes School of Medicine, Bogotá, Colombia.

Disorders of lipid and lipoprotein metabolism play a central role in the pathogenesis of atherosclerotic cardiovascular diseases (CVDs). Despite the widespread use of efficacious lipid-modifying therapies, the residual risk of CVD remains unacceptably high. The purpose of this manuscript is to review the application of new technologies in the treatment of lipid disorders. Read More

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http://dx.doi.org/10.24875/RIC.18002577DOI Listing
December 2018
2 Reads

FAMILIAL COMBINED HYPERLIPIDEMIA: CURRENT KNOWLEDGE, PERSPECTIVES, AND CONTROVERSIES.

Rev Invest Clin 2018 ;70(5):224-236

Metabolic Diseases Research Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Familial combined hyperlipidemia (FCHL) is the most prevalent primary dyslipidemia; however, it frequently remains undiagnosed and its precise definition is a subject of controversy. FCHL is characterized by fluctuations in serum lipid concentrations and may present as mixed hyperlipidemia, isolated hypercholesterolemia, hypertriglyceridemia, or as a normal serum lipid profile in combination with abnormally elevated levels of apolipoprotein B. FCHL is an oligogenic primary lipid disorder, which can occur due to the interaction of several contributing variants and mutations along with environmental triggers. Read More

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http://dx.doi.org/10.24875/RIC.18002575DOI Listing
December 2018
7 Reads

CONTROVERSIAL ISSUES IN THE TREATMENT OF DYSLIPIDEMIAS IN PATIENTS WITH DIABETES MELLITUS.

Authors:
Klaus G Parhofer

Rev Invest Clin 2018 ;70(5):237-243

Medizinische Klinik IV - Grosshadern, University of Munich, Munich, Germany.

Patients with diabetes mellitus have an elevated cardiovascular risk. Lipid-lowering therapy is a successful strategy to prevent atherosclerotic events in these patients. Therefore, almost all professional societies recommend statin therapy for patients with diabetes under certain conditions. Read More

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http://dx.doi.org/10.24875/RIC.18002574DOI Listing
December 2018
16 Reads

DYSLIPIDEMIA IN MEXICO, A CALL FOR ACTION.

Rev Invest Clin 2018 ;70(5):211-216

Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

The purpose of this manuscript is to highlight the peculiarities of the Mexican population regarding the clinical expression, genetics, and treatment of lipid disorders. Furthermore, it is a call for action to address the existing gaps in care and research of dyslipidemias. The Mexican Mestizos are highly susceptible to metabolic disorders (i. Read More

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http://dx.doi.org/10.24875/RIC.18002573DOI Listing
December 2018
15 Reads

LIPID DISORDERS: ADVANCES IN RESEARCH AND CHALLENGES IN CLINICAL PRACTICE.

Rev Invest Clin 2018 ;70(5):209-210

Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México.

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http://dx.doi.org/10.24875/RIC.M18000001DOI Listing
January 2018
1 Read

[Combined Preimplantation Genetic Testing for Aneuploidy and Monogenic Disease in a Mexican Family Affected by X-linked Hypohidrotic Ectodermal Dysplasia].

Rev Invest Clin 2018 ;70(4):164-168

Institute of Sciences in Human Reproduction "Vida", León, Gto., Mexico.

Background: Hypohidrotic ectodermal dysplasia (HED) is a genetic skin condition presenting as hypohidrosis, hypodontia, and hypotrichosis, resulting in an important burden for affected families. The most common form of HED has an X-linked inheritance and female carriers have the option of prenatal or preimplantation genetic testing (PGT) to avoid transmission of the disease. A combined PGT for a mutation in EDA gene and aneuploidies in a Mexican carrier of X-linked HED is reported. Read More

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http://dx.doi.org/10.24875/RIC.18002562DOI Listing
December 2018
28 Reads

[Roles of Donor/Recipient Body Surface Area Ratio and Donor Kidney Glomerular Filtration Rate in Kidney Selection for Living Transplantation from Family Members].

Rev Invest Clin 2018 ;70(4):169-176

Department of Urology, Army General Hospital of PLA, No. 5 Nanmencang, Dongsishitiao, Dongcheng District, Beijing, P. R. China.

Background: Accurate assessing donor renal function is crucial to the success of living kidney transplants. We studied the roles of donor kidney glomerular filtration rate (GFR) and donor/recipient body surface area (BSA) ratio in kidney selection for living transplantation from family members.

Methods: We included 204 recipients who were subjected to living kidney transplantation from family members in our hospital from February 2011 to February 2015 and followed up for over 2 years. Read More

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http://dx.doi.org/10.24875/RIC.18002518DOI Listing
December 2018
1 Read

[Primary Tumors of the Central Nervous System. Clinical Experience at a Third Level Center].

Rev Invest Clin 2018 ;70(4):177-183

Emergency Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.

Background: Central nervous system (CNS) tumors are a group of neoplasms that originate from various cells in the CNS. The increasing incidence and prevalence of this type of tumor in developing countries are striking; however, there are few current studies in Latin America including Mexico estimating the impact of these pathological entities on the general population.

Objective: The objective of the study was to study the characteristics of primary CNS tumors over a period of 52 years. Read More

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http://dx.doi.org/10.24875/RIC.18002399DOI Listing
December 2018
6 Reads

[Prediction of Molecular Signature, Potential Biomarkers, and Molecular Pathways Associated with Membranous Nephropathy Based on Protein Protein Interactions].

Rev Invest Clin 2018 ;70(4):184-191

Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Membranous nephropathy (MN) is one of the causes of nephrotic syndrome in adults that lead to end-stage renal disease with an unknown molecular signature. The current diagnosis is based on renal biopsy, which is an invasive method and has several complications and challenges. Thus, identification of the novel biomarker candidates, as well as impaired pathways, will be helpful for non-invasive molecular-based diagnosis. Read More

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http://dx.doi.org/10.24875/RIC.18002551DOI Listing
December 2018
21 Reads

[Association of Notified Cases and Treatment Success Rates in Pulmonary Tuberculosis].

Rev Invest Clin 2018 ;70(4):198-202

Division of Epidemiologic Surveillance of Transmissible Diseases, Coordinación de Vigilancia Epidemiológica, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Background: Tuberculosis has long been recognized as a public health problem in large cities. The goals of the "Stop TB" strategy of the WHO specifically promote its study at the subnational level. Therefore, we aimed to describe the state of pulmonary tuberculosis (PTB) at the municipality level in Mexico. Read More

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http://dx.doi.org/10.24875/RIC.17002389DOI Listing
December 2018
25 Reads

[Multimorbidity, Depressive Symptoms, and Self-Reported Health in Older Adults: a Secondary Analysis of the Sabe Bogota Study].

Rev Invest Clin 2018 ;70(4):192-197

Semillero de Neurociencias y Envejecimiento, Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.

Background: Multimorbidity and depressive symptoms (DSs) are common in older adults. Self-rated health (SRH) allows detection of elderly adults with a high burden of multimorbidity plus depression. The aim of this study was to test the association of groups of multimorbidity and DS on SRH in Colombian older adults. Read More

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http://dx.doi.org/10.24875/RIC.18002478DOI Listing
December 2018
2 Reads

[Clinical Applications of Next-Generation Sequencing].

Rev Invest Clin 2018 ;70(4):153-157

Genomics Laboratory, Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

The significant drop in sequencing costs boosted by chemistries optimization and sample multiplexation has resulted in an immense growth within the field of next-generation sequencing (NGS) in the last decade. This has allowed a diversification of techniques, promoting a rapid advance in knowledge on the molecular basis of human disease. Due to the applicability and importance of this technology in basic research, it has quickly migrated to the clinical setting. Read More

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http://dx.doi.org/10.24875/RIC.18002544DOI Listing
December 2018
18 Reads

[Borrelia Infection in Latin America].

Rev Invest Clin 2018 ;70(4):158-163

Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.

Lyme disease (LD) is a multisystemic inflammatory disease caused by pathogenic spirochetes, belonging to the genospecies complex Borrelia burgdorferi sensu lato (B.b.s. Read More

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http://dx.doi.org/10.24875/RIC.18002509DOI Listing
December 2018
10 Reads

Epidemiological Data on the Nutritional Status of Cancer Patients Receiving Treatment with Concomitant Chemoradiotherapy, Radiotherapy or Sequential Chemoradiotherapy to the Abdominopelvic Area.

Rev Invest Clin 2018 ;70(3):117-120

Instituto de Investigaciones Biomédicas UNAM-Instituto Nacional de Cancerología, Mexico City, Mexico.

Cancer patients are particularly susceptible to undernourishment so associated weight loss is frequent. Approximately 15% of patients lose >10% of their usual body weight, 40-80% become undernourished, and about 20% die as a result. Well-nourished patients have a higher survival rate when compared with patients at risk of undernourishment (19. Read More

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http://dx.doi.org/10.24875/RIC.18002523DOI Listing
December 2018
6 Reads

Effects of Dietary Components During and After Concomitant Chemoradiotherapy, Radiotherapy, or Sequential Chemoradiotherapy to the Abdominopelvic Area.

Rev Invest Clin 2018 ;70(3):126-129

Departments of Clinical Research, Medical Oncology, and Nutrition, Instituto Nacional de Cancerología, Mexico City, Mexico.

Radiotherapy is a fundamental part of the treatment of pelvic neoplasms. Up to 90% of patients develop gastrointestinal symptoms as a result of acute injury to the small and large intestine, particularly in the mucosa. Radiotherapy leads to atrophy of the intestinal epithelium, acute crypt inflammation, inflammatory infiltration of the epithelium, malabsorption of lactose, and biliary salts as well as alterations in pancreatic enzymes and biliary salts, resulting in the malabsorption syndrome and dysbiosis. Read More

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http://dx.doi.org/10.24875/RIC.18002525DOI Listing
December 2018
10 Reads

Nutrient Recommendations for Cancer Patients Treated with Pelvic Radiotherapy, with or without Comorbidities.

Rev Invest Clin 2018 ;70(3):130-135

Department of Clinical Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Radiotherapy is one of the main treatment options used in pelvic cancers. Ionizing radiation induces damage to surrounding tissues, resulting in disruption of normal physiological functions and symptoms such as diarrhea, tenesmus, incontinence, and rectal bleeding, which can all significantly alter the patient's quality of life. These patients are at increased risk of developing protein-calorie malnutrition and micronutrient deficiencies. Read More

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http://dx.doi.org/10.24875/RIC.18002526DOI Listing
December 2018
27 Reads

Nutritional Assessment Tools for the Identification of Malnutrition and Nutritional Risk Associated with Cancer Treatment.

Rev Invest Clin 2018 ;70(3):121-125

Nutrition Division, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Malnutrition and muscle wasting are common features of cancer cachexia that may interfere with the patient's response to cancer treatment, survival, and quality of life. An accurate nutritional screening at the time of diagnosis and throughout the patient's treatment fosters better control of the disease. Several screening tools have proven to be useful for this purpose. Read More

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http://dx.doi.org/10.24875/RIC.18002524DOI Listing
December 2018
2 Reads

Epidemiological Profile, Gastrointestinal Toxicity, and Treatment of Pelvic Cancers in Patients Managed with Radiotherapy to the Abdominal Pelvic Area.

Rev Invest Clin 2018 ;70(3):112-116

General Direction, Instituto Nacional de Cancerología, Mexico City, Mexico.

Mexico has seen an increase in cancer prevalence in its entire population as well as particular age ranges, predominantly the older segment. The most frequently reported pelvic cancers in Mexico are cervical, endometrial, bladder, prostate, rectum, and anal canal. Approximately 80% of the population diagnosed with pelvic cancers present with locally advanced tumors and require concomitant chemoradiotherapy, sequential chemoradiotherapy, or radiotherapy alone. Read More

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http://dx.doi.org/10.24875/RIC.18002528DOI Listing
December 2018
25 Reads

Nutrition in Patients with Cancer Treated with Chemo-radiotherapy to the Abdominopelvic Area. A consensus report.

Rev Invest Clin 2018;70(3):109-111

Department of Clinical Research, Instituto Nacional de Cancerología, Mexico City, and Revista de Investigación Clínica - Clinical and Translational Investigation, Mexico City, Mexico.

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http://dx.doi.org/10.24875/RIC.18002521DOI Listing
December 2018
3 Reads

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment.

Rev Invest Clin 2018 ;70(3):136-146

Departments of Nutrition, Medical Oncology, and Clinical Research, Instituto Nacional de Cancerología, Mexico City, Mexico.

In cancer patients treated with radiotherapy to the abdominopelvic region, dietary modifications and the use of functional foods (fortified food with added ingredients to provide specific health improving benefits, such as antioxidants, omega-3 fatty acids, and glutamine), may contribute to the improvement of the toxic effects of treatment, including nausea, diarrhea, and constipation, among others. With the aim of analyzing which coadjuvant foods benefit these patients, scientific evidence was gathered by a group of experts. For these patients, the authors recommend a diet that includes sufficient foods rich in antioxidants and polyphenols instead of supplements. Read More

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http://dx.doi.org/10.24875/RIC.18002527DOI Listing
December 2018
13 Reads

Ketamine for Treatment-Resistant Depression: a New Advocate.

Rev Invest Clin 2018 ;70(2):65-7

Department of Neuropsychiatry, Instituto Nacional de Neurología y Neurocirugía, SSA, Mexico City, Mexico.

Current alternatives for the treatment of major depressive disorder lack efficacy and have a delayed onset of action. Recently, the glutamatergic neurotransmission system has been noted to play an important role in the pathophysiology of this disorder. Ever since the first report of the antidepressant effects of the N-methyl-D-aspartate receptor antagonist, ketamine, research has been redirected to novel therapeutic targets. Read More

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http://dx.doi.org/10.24875/RIC.18002501DOI Listing
October 2018
6 Reads

Schwann Cell Precursor Transplant in a Rat Spinal Cord Injury Model.

Rev Invest Clin 2018 ;70(2):88-95

Department of Human Anatomy, Microsurgery Laboratory, Universidad Autónoma de Nuevo León, N.L., Mexico.

Background: Differentiation of mesenchymal stem cells into Schwann cell precursors could reverse established lesions and sequelae of medullary transection.

Objective: The objective of this study was to study the clinical response of mesenchymal stem cell transplantation with Schwann precursor cell transplantation in a rat spinal cord injury model, using motor function and histopathologic studies.

Materials And Methods: A total of 28 Sprague-Dawley rats were randomly divided among four groups (n = 7 in each): sham group, control group, mesenchymal stem cell transplant group, and Schwann cell precursor transplant group. Read More

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http://dx.doi.org/10.24875/RIC.18002466DOI Listing
October 2018
1 Read

Association of Intron-2 Variable Numbers of an 86-bp Tandem Repeat-Polymorphisms of Interleukin-1 Receptor Antagonist Gene and Idiopathic Recurrent Spontaneous Abortion.

Rev Invest Clin 2018 ;70(2):96-102

Universidad Nacional Autónoma de México School of Medicine, Branch at Instituto Nacional de Medicina Genómica, Mexico City, Mexico.

Background: It has been proposed that abnormal modulation of inflammatory response is involved in the physiopathology of idiopathic recurrent spontaneous abortion (iRSA). Factors that may participate in this process include the genetic background such as carrying specific polymorphisms of genes with functional effects.

Objective: The objective is to study the association between iRSA and the frequency of intron-2 variable number tandem repeat-polymorphisms of interleukin-1 receptor antagonist gene (IL1RN). Read More

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http://dx.doi.org/10.24875/RIC.18002485DOI Listing
October 2018
12 Reads

Phenotypic Variability in a Mexican Mestizo Family with Retinal Vasculopathy with Cerebral Leukodystrophy and TREX1 Mutation p.V235Gfs*6.

Rev Invest Clin 2018 ;70(2):68-75

Clinical Laboratory of Neurodegenerative Diseases, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico.

Background: Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an adult-onset, autosomal dominant disease involving microvessels of the brain and eye resulting in central nervous system degeneration with visual disturbances, stroke, motor impairment, and cognitive decline. Frameshift mutations at the C-terminus of TREX1 gene are the molecular cause of this disorder.

Objectives: The objective of this study is to present the different clinical manifestations of RVCL in three-related patients and to investigate the presence of TREX1 mutation in the extended genealogy. Read More

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http://dx.doi.org/10.24875/RIC.18002492DOI Listing
October 2018
11 Reads

Pulmonary Vasoreactivity and Phenotypes in Pulmonary Arterial Hypertension Associated to Connective Tissue Diseases.

Rev Invest Clin 2018 ;70(2):82-7

Department of Cardiopulmonary Disease, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Background: Pulmonary arterial hypertension (PAH) is a fatal complication in patients with connective tissue disease (CTD).

Objective: The objective of the study was to study the prognostic value of the acute pulmonary vasoreactivity test with inhaled iloprost and its association with clinical deterioration in a tertiary care academic medical center.

Methods: We conducted a prospective study of patients with CTD and the diagnosis of PAH established by right heart catheterization. Read More

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http://dx.doi.org/10.24875/RIC.18002437DOI Listing
October 2018
6 Reads

Correlation between Lung and Joint Involvement in Patients with Rheumatoid Arthritis and Interstitial Lung Disease: A Cross-Sectional Study.

Rev Invest Clin 2018 ;70(2):76-81

Interstitial Lung Disease Clinic, María Ferrer Hospital, Buenos Aires, Argentina, PA, USA.

Background: Rheumatoid arthritis (RA) can affect the lungs in different manners, with interstitial lung disease (ILD) as the most serious manifestation. Although lung and joint compromise could be thought to evolve in parallel, there are data suggesting the opposite. In this study, we evaluated the relationship between lung and joint involvement in RA ILD. Read More

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http://dx.doi.org/10.24875/RIC.18002474DOI Listing
October 2018
5 Reads

A prognostic score for survival in patients older than 65 years with Diffuse Large B-Cell Lymphoma.

Rev Invest Clin 2018 ;70(1):46-52

Clinical Research Division, Instituto Nacional de Cancerología, Mexico City, Mexico.

Background: Available prognosis scores for patients with diffuse large B-cell lymphoma (DLBCL) included a limited number of patients ≥ 65 years of age, and most of them did not include comorbidities. Here, we propose a prognostic score for overall survival (OS) for this group of patients.

Materials And Methods: Patients ≥ 65 years with DLBCL treated at a single national reference center were included. Read More

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http://dx.doi.org/10.24875/RIC.18002450DOI Listing
September 2018
2 Reads

Chewing Xylitol Gum could Accelerate Bowel motility Recovery after Elective Open Proctectomy for Rectal Cancer.

Rev Invest Clin 2018 ;70(1):53-58

Department of Gastrointestinal Surgery, The East Branch of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China Affiliated Hospital & Sichuan Provincial People's Hospital, Chengdu 610110, Sichuan Province, China.

Background: A number of studies with conflicting results have evaluated the effect of chewing gum on post-operative gastrointestinal recovery in patients after major colorectal surgery.

Objective: The objective of the study was to study the efficacy of chewing gum in patients with rectal cancer after elective open proctectomy only.

Methods: A randomized controlled clinical trial was performed. Read More

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http://dx.doi.org/10.24875/RIC.18002428DOI Listing
September 2018
6 Reads

Innate Immunity in Coronary Disease. The Role of Interleukin-12 Cytokine Family in Atherosclerosis.

Rev Invest Clin 2018 ;70(1):5-17

Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Atherosclerosis is a chronic, progressive, and multifactorial disease modulated by genetic and environmental factors. In recent years, the paradigm that explained atherosclerosis as resulting from a complex interaction between factors not accessible to medical intervention, and modifiable risk factors has changed. In this paradigm, alterations in lipid metabolism were the pivotal concept of atherosclerosis as a chronic degenerative disease. Read More

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http://dx.doi.org/10.24875/RIC.17002335DOI Listing
September 2018
4 Reads

Changing Trends in Gastric Polyps.

Rev Invest Clin 2018 ;70(1):40-45

Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: The prevalence of gastric polyps varies around the world reflecting regional associations. We describe demographic features of patients with gastric polyp diagnosis treated between 1980 and 2016 at a referral center in Mexico City and analyzed trends of polyp subtype.

Materials And Methods: We conducted a blind review of archival slides of gastric biopsies with polyp diagnosis from the years 1980, 1990, 2000, 2010, and 2016. Read More

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http://dx.doi.org/10.24875/RIC.17002430DOI Listing
September 2018
11 Reads

Heading Toward the Elimination of Hepatitis C Virus.

Rev Invest Clin 2018 ;70(1):29-31

Direction of Interinstitutional and Social Communication, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Chronic hepatitis C is often asymptomatic and may progress over the years to cirrhosis and hepatocellular carcinoma. Although the prevalence and incident cases are decreasing, the peak mortality of hepatitis C virus (HCV)-related complications is ahead of us in most countries. The economic impact of this burden is enormous. Read More

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http://dx.doi.org/10.24875/RIC.18002467DOI Listing
September 2018
2 Reads

Cytotoxic Activity of a Black Bean (Phaseolus vulgaris L.) Extract and its Flavonoid Fraction in Both In Vitro and In Vivo Models of Lymphoma.

Rev Invest Clin 2018 ;70(1):32-39

Tecnológico de Monterrey, Centro de Biotecnología-FEMSA, Monterrey, N.L., Mexico.

Background: Black bean (Phaseolus vulgaris L.) is a very common legume seed in Mexican diet. Flavonoids and crude extracts from different plants have been reported as effective agents for chemoprevention and cytotoxicity in several cancer cell lines. Read More

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http://dx.doi.org/10.24875/RIC.17002395DOI Listing
September 2018
5 Reads

NOD2: Activation During Bacterial and Viral Infections, Polymorphisms and Potential as Therapeutic Target.

Rev Invest Clin 2018 ;70(1):18-28

Sección de Inmunovirología, Laboratorio de Virología, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.

Nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptors or NLRs are a family of receptors that detect both, molecules associated to pathogens and alarmins, and are located mainly in the cytoplasm. NOD2 belongs to the NLR family and is a dynamic receptor capable of interacting with multiple proteins and modulate immune responses in a stimuli-dependent manner. The experimental evidence shows that interaction between NOD2 structural domains and the effector proteins shape the overall response against bacterial or viral infections. Read More

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http://dx.doi.org/10.24875/RIC.17002327DOI Listing
September 2018
4 Reads

Two-hundred Years Later: Is Parkinson's Disease a Single Defined Entity?

Rev Invest Clin 2017 Nov-Dec;69(6):308-313

Neurological Tissue Bank, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid and Universidad de Barcelona, Barcelona, Spain.

An Essay on the Shaking Palsy, by James Parkinson, was published in 1817. Later, Jean-Martin Charcot better described some of the motor features of the disease and named the condition as "La Maladie de Parkinson." As understanding about the disease progressed, aided by both clinical expertise and technological developments, the definition of what is Parkinson's disease has evolved. Read More

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http://dx.doi.org/10.24875/RIC.17002291DOI Listing
July 2018
3 Reads