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Rev Neurol 2019 Feb;68(4):179-180

Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia, Portugal.

Rev Neurol 2019 Feb;68(4):171-178

Rev Neurol 2019 Feb;68(4):169-170

Hospital Universitario Donostia, San Sebastian, Espana.

Rev Neurol 2019 Feb;68(4):160-168

Hospital Universitari de Bellvitge, Hospitalet de Ll., Espana.

Cognitive toxicity induced by cranial radiation is one of the most important limitations of radiation therapy and has a significant impact on brain tumor survivors' quality of life. This review comprehends an up to date of recent studies including complete neuropsychological battery and/or advanced neuroimaging techniques. These studies identified critical anatomical and/or functional brain areas related to radiation-induced brain injury, thus improving clinical and radiological diagnosis. Read More

Rev Neurol 2019 Feb;68(4):155-159

Hospital de Ninos de la Santisima Trinidad, Cordoba, Argentina.

Introduction: CLN8 disease is one of the thirteen recognized genetic types of neuronal ceroid lipofuscinosis, a group of neurodegenerative lysosomal storage disorders, most frequent in childhood. A putative 286 amino acids transmembrane CLN8 protein with unknown function is affected. Pathological variants in the CLN8 gene were associated with two different phenotypes: variant late-infantile in individuals from many countries worldwide, and epilepsy progressive with mental retardation, appearing in Finnish and Turkish subjects. Read More

Rev Neurol 2019 Feb;68(4):147-154

Departamento de Salud del Gobierno Vasco, Bilbao, Espana.

Introduction: The relationship between socioeconomic status and incidence or stroke mortality rates is well established. The evidence of an association between this variable and survival is less conclusive. Level of education is a widely-used measure of socioeconomic status in elderly people. Read More

Rev Neurol 2019 Feb;68(4):137-146

Division de Ciencias de la Salud. Universidad de Quintana Roo, Chetumal, Quintana Roo, Mexico.

Introduction: Hazardous alcohol consumption (HAC) is a pattern of alcohol use that may result in harm for the user and/or for those around them. Prior research has suggested that HAC and alcohol dependence share some neurophysiological features but differ in others.

Aim: To determine whether HAC and alcohol dependence presented different neurophysiological correlates. Read More

Rev Neurol 2019 Feb;68(4):135-136

Hospital Rey Juan Carlos, Mostoles, Espana.

Rev Neurol 2019 Feb;68(3):134

CARIBRO/ I.C.B.P , Habana, Cuba.

Rev Neurol 2019 Feb;68(3):132-133

Hospitals Vall d'Hebron, 08035 Barcelona, Espana.

Rev Neurol 2019 Feb;68(3):131-132

Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Rev Neurol 2019 Feb;68(3):125-130

Rev Neurol 2019 Feb;68(3):123-124

Hospital San Juan de la Cruz, 23400 Ubeda, Espana.

Rev Neurol 2019 Feb;68(3):118-122

Universidad Miguel Hernandez, Elche, Espana.

Aim: To develop a proposal for a portfolio of services and a set of indicators for Headache Units.

Development: Qualitative study that applied techniques of consensus with the participation of 15 professionals who are experts in the treatment of headaches (experience of 15 years) and in quality assurance. The description of the indicators included: statement, definition, standard, type of indicator, dimension, source, level of evidence, and clarification of terms. Read More

Rev Neurol 2019 Feb;68(3):111-117

Hospital San Pedro, Logrono, Espana.

Introduction: The microbiota is the set of millions of microorganisms that coexist in a symbiotic way in our body. It is mainly located in the digestive tract, being distributed in function of the chemical properties and the functions of the different organs. The factors that influence its composition are multiple (diet, individual habits, diseases or drugs). Read More

Rev Neurol 2019 Feb;68(3):107-110

Hospital General Universitario Gregorio Maranon, Madrid, Espana.

Introduction: The pathophysiology of restless legs syndrome (RLS) is complex. Secondary RLS with iron deficiency -which suggests disturbed iron homeostasis- remains to be elucidated.

Case Reports: We report the findings from a unique blood donor family with RLS. Read More

Rev Neurol 2019 Feb;68(3):99-106

Facultad de Psicologia. Universidad Autonoma de Barcelona., Bellaterra (Cerdanyola del Valles), Espanya.

Introduction: The 22q11 deletion syndrome (S22q11) is a genetic disorder caused by the loss of a fragment of the chromosome 22. The clinical manifestations associated with the syndrome are diverse, including learning difficulties and alterations in voice, speech and language. However, to date we have not found any study that evaluates these aspects in the Spanish population with S22q11. Read More

Rev Neurol 2019 Feb;68(3):91-98

Hospital General de Mexico OD, Cuauhtemoc, Mexico.

Introduction: Since, under certain circumstances, defensive or attacking behaviours display a pattern of motor dominance, as observed in subjects who participate in contact or fighting sports, aggressive behaviour was considered to have a dominant motor pattern. With the aim of preventing the functional problems reported with bilateral lesion procedures involving both the central nucleus of the amygdala and the posteromedial hypothalamus, the decision was made to combine them; thus, an amygdalotomy of the central nucleus of the amygdala and a posteromedial hypothalamotomy were to be performed simultaneously and unilaterally, on the basis of the motor dominance of the patient determined by means of the Edinburgh test.

Patients And Methods: This study describes the surgical experience in a series of nine patients diagnosed with refractory neuroaggressive syndrome. Read More

Rev Neurol 2019 Jan;68(2):89-90

Complejo Hospitalario Universitario de Vigo, Vigo, Espana.

Rev Neurol 2019 Jan;68(2):82-88

Hospital Clinico de la Universidad de Chile, Santiago de Chile, Chile.

Lethargic encephalitis is a neurological illness that shows a wide range of symptoms and signs, including neurological and psychiatric spectrum. It presented in an epidemic way, following influaenza relapses. The last relapse started at the beginning of 20th century and it was deeply described by Constantin von Economo. Read More

Rev Neurol 2019 Jan;68(2):75-81

Omakase Consulting, Barcelona, Espana.

Introduction: Dravet syndrome (DS) is a rare, drug resistant epilepsy that starts very early in life with febrile seizures followed by cognitive impairment and diverse seizure types.

Aim: To generate evidence on the epidemiology of DS, its diagnosis, patient-flow, treatment and unmet needs from the perspective of Spanish experts.

Development: A two-round Delphi study involving 19 physicians was conducted. Read More

Rev Neurol 2019 Jan;68(2):66-74

Fundacion Argibide, Pamplona, Espana.

Introduction: Lafora disease is autosomal recessive progressive myoclonus epilepsy with late childhood-to teenage-onset caused by loss-of-function mutations in either EPM2A or EPM2B genes encoding laforin or malin, respectively.

Development: The main symptoms of Lafora disease, which worsen progressively, are: myoclonus, occipital seizures, generalized tonic-clonic seizures, cognitive decline, neuropsychiatric syptoms and ataxia with a fatal outcome. Pathologically, Lafora disease is characterized by the presence of polyglucosans deposits (named Lafora bodies), in the brain, liver, muscle and sweat glands. Read More

Rev Neurol 2019 Jan;68(2):59-65

Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico DF, Mexico.

Introduction: Primary lymphoma of the central nervous system is a variety of non-Hodgkin's lymphoma that accounts for 4-5% of intracranial tumours and 5% of all lymphomas. It has its origin in the brain, the eyes, the leptomeninges and the spinal cord with no systemic evidence of lymphomatoid activity; the subtype of lymphoma is predominantly of B-type cells.

Patients And Methods: We conducted a descriptive study of the patients diagnosed with primary brain lymphoma who were attended to at third-level centres in Mexico between the years 1980 and 2016. Read More

Rev Neurol 2019 Jan;68(2):47-58

Universidad de Valencia, 46071 Valencia, Espana.

Introduction: Kahneman and Tversky's prospect theory has become the main model for the study of decision-making. One of its cornerstones, the loss aversion bias (greater sensitivity to losses than to gains), has been demonstrated from the behavioural perspective.

Aims: To analyse the evidence from neuroeconomics and check whether it is consistent with the existence of a neural mechanism of loss aversion. Read More

Rev Neurol 2019 Jan;68(1):45-46

Hospital General Universitario Gregorio Maranon, Madrid, Espana.

Rev Neurol 2019 Jan;68(1):44-45

Centro Nacional de Investigaciones Cientificas (CNIC), Playa, La Habana, Cuba.

Rev Neurol 2019 Jan;68(1):44

Universidad de Ciencias Medicas de La Habana, La Habana, Cuba.

Rev Neurol 2019 Jan;68(1):37-43

Rev Neurol 2019 Jan;68(1):23-36

Universidad del Pais Vasco, Leioa, Espana.

Introduction: Perinatal asphyxia remains a major cause of both mortality and neurological morbidity. Neonatal encephalopathy affects to 1-3/1,000 newborns, leading to significant brain damage and childhood disability. The only standard therapy is moderate hypothermia, whose efficacy, despite proved, is limited, being partially effective. Read More

Rev Neurol 2019 Jan;68(1):18-22

Hospital de Mataro. Consorci Sanitari del Maresme, 08304 Mataro, Espana.

Introduction: Encephalitis due to anti-NMDA receptor antibodies is an acute and severe condition, which, if identified and treated quickly, can entail recovery without any sequelae. It is more prevalent in young females and is often associated with an underlying tumour. The initial symptoms are usually of a psychiatric nature, and in a matter of days or weeks take on a characteristic neurological profile. Read More

Rev Neurol 2019 Jan;68(1):11-17

Universidad Complutense de Madrid, Madrid, Espana.

Introduction: Pusher behaviour is an alteration of postural control and the perception of the midline which occurs in some patients after suffering a stroke and it has important functional consequences, so its evaluation is essential.

Aim: To translate into Spanish and to validate the Burke Lateropulsion Scale (BLS), used to evaluate the signs of pusher behaviour in patients.

Patients And Methods: To achieve the proposed objectives, a translation-back translation into Spanish of the scale was performed and the validity and reliability of a sample of post-stroke patients was evaluated. Read More

Rev Neurol 2019 Jan;68(1):7-10

HUMS. Hospital Universitario Miguel Servet, 50009 Zaragoza, Espana.

Introduction: Patients with neurofibromatosis type 1 (NF1) have a high predisposition to develop attention-deficit disorder. The aim of this study is to determine the prevalence of NF1 patients with attention-deficit/hyperactivity disorder (ADHD) diagnosis attending our Child Neurology Department. We assess patient adherence and medical treatment outcomes. Read More

Rev Neurol 2019 Jan;68(1):1-6

Universidad de Alicante, 03080 Alicante, Espana.

Introduction: There is great interest in studies on the implications that gut microbiota exerts on the behavior of people with autism spectrum disorders (ASD), through the microbiota-gut-brain axis. Most studies on microbiota are focused on the possible involvement of bacteria on people with ASD, but few of them are focussed on the effect of microorganisms in the Fungi kingdom.

Subjects And Methods: The present study performs a systematic review of the presence of Candida spp. Read More

Rev Neurol 2018 Dec;67(12):513-514

Hospital General de Ciudad Real, Ciudad Real, Espana.

Rev Neurol 2018 Dec;67(12):505-512

Universidad Autonoma Metropolitana-Xochimilco, Mexico DF, Mexico.

Introduction: Recent contributions to the specialised literature address the topic of body transplantation, mostly produced by Sergio Canavero and a group of researchers from China. For several years they have been announcing that they will carry out the procedure, but it has still not been performed.

Aims: The aim of this study is to perform a neuroethical analysis of body transplantation, based on the methodology of Diego Gracia on ethics and bioethics and an analysis of facts, values and duties. Read More

Rev Neurol 2018 Dec;67(12):491-504

Centro de Biologia Molecular Severo Ochoa. Universidad Autonoma de Madrid, Madrid, Espana.

Introduction: The amino acids glutamate and glycine, apart from their role in protein synthesis, are two fundamental neurotransmitters in the central nervous system of mammals. The first one is ubiquitous and is involved in excitatory pathways of the neocortex, the retina and the cerebellum, and the second is involved in inhibitory pathways of brain caudal areas. However, both share their way of acting by integrating into the functioning of glutamate receptors of the NMDA type fundamentals in the regulation of motor, sensory and cognitive systems. Read More

Rev Neurol 2018 Dec;67(12):484-490

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

Introduction: The different types of viral meningitis constitute a condition that is relatively frequent in newborn infants, although in many cases they are underdiagnosed due to the absence of pleocytosis in the cerebrospinal fluid (CSF).

Aims: To describe the clinical features and laboratory findings of newborn infants with viral meningitis and to highlight the importance of the polymerase chain reaction (PCR) in the CSF to diagnose this condition.

Patients And Methods: A retrospective review of the medical records of newborn infants hospitalised in the neonatology section who had been diagnosed with viral meningitis between May 2014 and May 2017. Read More

Rev Neurol 2018 Dec;67(12):473-483

Universidad Rey Juan Carlos, 28922 Alcorcon, Espana.

Introduction: New treatment options are emerging within the information and communication technologies field through smartphones in order to treat multiple sclerosis (MS) patients.

Aim: To carry out a systematic review about the information related to mobile applications specifically designed in the field of MS, in order to classify them and carry out a description of their main characteristics.

Subjects And Methods: A literature search of articles published in English and Spanish has been carried out from 2012 until 2017 that presents, analyzes and validates a system based on an application with utility or specific design for MS. Read More

Rev Neurol 2018 Dec;67(12):465-472

Hospital Clinico San Carlos, 28040 Madrid, Espana.

Introduction: Studies on focal dystonia showed that the formulations of botulinum toxin type A, incobotulinumtoxin-A (Inco-BTA) and onabotulinumtoxin-A (Ona-BTA), have equivalent efficacy and safety.

Aim: To carry-out a cost-utility analysis of Inco-BTA administered on flexible intervals vs. Ona-BTA on a fixed interval, in the treatment of blepharospasm and cervical dystonia. Read More

Rev Neurol 2018 Dec;67(11):464

IMSS. Instituto Mexicano del Seguro Social, Veracruz, Mexico.

Rev Neurol 2018 Dec;67(11):463-464

Facultad de Ciencias Medicas Doctor Miguel Enriquez, La Habana, Cuba.

Rev Neurol 2018 Dec;67(11):461-463

Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

Rev Neurol 2018 Dec;67(11):453-460

Universidad Autonoma de la Ciudad de Mexico, Mexico DF, Mexico.

Introduction: Adverse life experiences promote the development of mental illness such as depression, anxiety or schizophrenia. However, some individuals are capable to overcome adversity, achieving a physical and psychological normal development; this process is known as resilience.

Aim: To discuss the neuronal substrates of resilience. Read More

Rev Neurol 2018 Dec;67(11):441-452

Universidad Complutense de Madrid. Facultad de Medicina, 28040 Madrid, Espana.

Introduction: Genitourinary cancers constitute a heterogeneous and increasingly frequent group of malignant tumors that have the potential to derive directly, or indirectly from the treatment applied, in a series of neurological complications that negatively impact on the quality of life of the patients who suffer them.

Aims: To report the most relevant data on the main neurological complications of genitourinary cancers.

Development: We conducted a PubMed search for articles, latest books, leading clinical practice guidelines, and scientific societies, regarding the appearance of such complications. Read More

Rev Neurol 2018 Dec;67(11):436-440

Complejo Hospitalario Universitario de Vigo, 36200 Vigo, Espana.

Introduction: The behavioural variant of frontotemporal dementia is characterised by progressive social, cognitive and personality deterioration associated with several molecular pathologies of frontotemporal lobar dementia (FTLD): FTLD-tau, FTLD-TDP and FTLD-FUS. Its diagnosis requires pathological studies.

Case Report: A 61-year-old male, with a three-year progressive history of behavioural disorder, apathy, poor language skills, perseveration, lack of empathy, bulimia and executive dysfunction. Read More

Rev Neurol 2018 Dec;67(11):425-435

Universitat Internacional de Catalunya, Sant Cugat del Valles, Espana.

Introduction: The quality of life related to health of children with pediatric neuromuscular diseases is studied from the perspective of self-perception and parent-perception. It is therefore essential to dispose valid scales such as Pediatric Quality of Life inventory (PedsQL) Neuromuscular Module for its correct assessment.

Aim: To assess the validity and reliability of the Spanish version of PedsQL Neuromuscular Module for self-perceived and parent-perceived quality of life of children aged 8-18 with neuromuscular disorders. Read More

Rev Neurol 2018 Dec;67(11):417-424

Hospital Universitario Central de Asturias, Oviedo, Espana.

Introduction: The course of multiple sclerosis is characterised by the development of cerebral atrophy. It is of interest to monitor it in order to evaluate the treatment response, and the preferred technique consists in performing brain volume analyses, which are currently restricted to the field of research.

Aim: To analyse the corpus callosum index (CCI) as a possible alternative to the methods based on brain segmentation. Read More

Rev Neurol 2018 Nov;67(s01):S1-S21

Hospital La Fe, 46009 Valencia, Espana.

«Apuntes en Neurologia» is an initiative in which prominent national and international leaders, with broad academic recognition, came together to synthesise the most outstanding clinical aspects within their area of interest and to discuss the latest developments in a more accessible language. Understanding the factors that affect the onset and progression of any neurological disease through a review is important to be able to develop strategies to reduce the burden of these diseases. Moreover, knowledge of the clinical aspects is essential to solve the problems of daily clinical practice. Read More

Rev Neurol 2018 Nov;67(10):415-416

Hospital Universitario Puerta del Mar, 11009 Cadiz, Espana.

Rev Neurol 2018 Nov;67(10):403-414