466 results match your criteria Reviews on Recent Clinical Trials[Journal]


Preface.

Rev Recent Clin Trials 2019 ;14(1)

Associate Professor of Gastroenterology Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.

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http://dx.doi.org/10.2174/157488711401190110101233DOI Listing
January 2019

Mitral Stenosis in Pregnancy: A Comprehensive Review of a Challenging Cardio-Obstetric Clinical Entity.

Rev Recent Clin Trials 2019 Feb 7. Epub 2019 Feb 7.

Department of Cardiology, University Heart Center at university Hospital Zurich. Switzerland.

Background: Mitral stenosis is one of the most commonly encountered valvular heart diseases during pregnancy, the majority are rheumatic in origin and poorly tolerated due to cardio circulatory changes that occur during pregnancy, labor and postpartum.

Objective: The distinctive physiological events that arise during pregnancy and labor and the influence of mitral stenosis are tackled in this article.

Method: Through PUBMED and MEDLINE searches, we reviewed the literature of the last decade as well as the recommendations from guidelines of high-impact worldwide. Read More

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http://dx.doi.org/10.2174/1574887114666190207154413DOI Listing
February 2019
1 Read

Clinical Trial Data Management Software: A Review of the Technical Features.

Rev Recent Clin Trials 2019 Feb 7. Epub 2019 Feb 7.

Department of Epidemiology, School of Health, Iran University of Medical Sciences, Tehran. Iran.

Background: Data management is an important, complex and multidimensional process in clinical trials. The execution of this process is very difficult and expensive without the use of information technology. A clinical data management system is software that is vastly used for managing the data generated in clinical trials. Read More

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http://dx.doi.org/10.2174/1574887114666190207151500DOI Listing
February 2019

Effect of a Physical Activity Program on Serum Biochemical Parameters among Elderly Women.

Rev Recent Clin Trials 2019 Jan 31. Epub 2019 Jan 31.

Social Determinants of Health Research Center (SDH), Qazvin University of Medical Sciences, Qazvin. Iran.

Background: The present study examined the efficacy of walking program on biochemical parameters among elderly women.

Methods: A total of one hundred elderly women participated in this randomized clinical trial study. The intervention group attended a 24-week walking exercise meeting five times per week. Read More

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http://dx.doi.org/10.2174/1574887114666190201113809DOI Listing
January 2019

Laparoscopic Incisional and Ventral Hernia Repair with Absorbable Tacks in a Long Term Follow-up: A Retrospective Control Study.

Rev Recent Clin Trials 2019 Jan 31. Epub 2019 Jan 31.

General Surgery, S. Maria del Carmine Hospital, Rovereto. Italy.

Background: Laparoscopic incisional and ventral hernia repair (LIVHR) is a safety and worldwide accepted procedure performed using also absorbable tacks. The aim of the study was to evaluate recurrence rate in a long term follow-up and whether the results of laparoscopic IVH repair in the elderly (≥65 years old) are different with respect to results obtained in younger patients.

Patients And Methods: One hundred and twenty-nine consecutive patients (74 women and 55 men, median age 67 years, range=30-87years) with ventral (N=42, 32. Read More

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http://dx.doi.org/10.2174/1574887114666190201111332DOI Listing
January 2019
1 Read

Off-pump Techniques of Surgical Myocardial Revascularization.

Rev Recent Clin Trials 2019 Jan 31. Epub 2019 Jan 31.

Cardiac Surgery Department San Camillo-Forlanini Hospital Circumvallation Gianicolense 87 Rome. Italy.

Background: Before the advent of CABG, standardized in the late '60s by Favaloro and Effler, patients with myocardial ischemia were treated with indirect methods and Off--pump procedures to achieve myocardial revascularization have been quite heterogeneous in the past.

Methods & Results: Indirect revascularization such as Periaortic nerve plexus interruption, Vineberg operation, Sen procedure, TMR Laser and stem cell transplantation represented some of the way to obtain a revascularization in the past period. Direct revascularization represents nowadays the most used technique in order to obtain a blood supply to ischemic heart. Read More

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http://dx.doi.org/10.2174/1574887114666190201112053DOI Listing
January 2019
1 Read

Trials Comparing Percutaneous And Surgical Myocardial Revascularization: A Review.

Rev Recent Clin Trials 2019 Jan 31. Epub 2019 Jan 31.

Department of Emergency and Organ Transplant, Division of Cardiac Surgery, University of Bari Aldo Moro, Bari. Italy.

Introduction: Ischemic heart diseases are the major leading cause of death worldwide. Revascularization procedures dramatically reduced the overall risk for death related to acute coronary syndromes. Two kind of myocardial revascularization can grossly be outlined: percutaneous coronary intervention (PCI) and surgical coronary artery bypass graft intervention (CABG). Read More

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http://dx.doi.org/10.2174/1574887114666190201102353DOI Listing
January 2019
3 Reads

Age-related Trends in Adults with Urinary Tract Infections Presenting to the Emergency Department: A 5-Year Experience.

Rev Recent Clin Trials 2018 Dec 26. Epub 2018 Dec 26.

Emergency Department, Catholic University of Rome, Fondazione Policlinico A. Gemelli. Italy.

Introduction: Urinary tract infections (UTIs) are among the most common bacterial infections, affecting 150 million people worldwide each year. Importantly, the incidence of UTI increases markedly with age. The increasing resistance to empirically prescribed antimicrobial agents complicates the management of this disease. Read More

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http://dx.doi.org/10.2174/1574887114666181226161338DOI Listing
December 2018
1 Read

Advanced Non Small Cell Lung Cancer with activating Epidermal Growth Factor Receptor mutation: First line treatment and beyond.

Rev Recent Clin Trials 2018 Dec 5. Epub 2018 Dec 5.

Division of Medical Oncology, AORN Giuseppe Moscati, Avellino. Italy.

Background: Lung cancer is the leading cause of cancer mortality, being responsible for more than 1.6 million deaths each year worldwide and non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers; moreover, 10 to 15% of all NSCLCs harbors EGFR (epidermal growth factor receptor) activating mutations, being suitable for EGFR-Tyrosine Kinase Inhibitors (TKI) molecular targeted therapy. However, EGFR+ NSCLCs gain acquired resistance to these agents, representing one of the key challenges for modern precision oncology. Read More

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http://dx.doi.org/10.2174/1574887114666181205155211DOI Listing
December 2018
4 Reads

Unsolved issues in the treatment of spontaneous peritonitis in patients with cirrhosis: nosocomial versus community-acquired infections and the role of fungi.

Rev Recent Clin Trials 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples Federico II, 80131, Naples. Italy.

Introduction: Historically, spontaneous bacterial peritonitis (SBP) has represented one of the most frequent and relevant infectious complications of advanced liver disease, and this is still valid today. Nevertheless, in recent years the role of fungi as causative pathogens of primary peritonitis in patients with cirrhosis has become not negligible. Another issue is linked with the traditional distinction, instrumental in therapeutic choice, between community-acquired and nosocomial forms, according to the onset. Read More

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http://dx.doi.org/10.2174/1574887114666181204102516DOI Listing
December 2018
4 Reads

Malignant Pleural Effusion: Still a Long Way to Go.

Authors:
Fausto Meriggi

Rev Recent Clin Trials 2019 ;14(1):24-30

Oncology Department - Poliambulanza Foundation, Brescia, Italy.

Background: Malignant pleural effusion, which is a common clinical problem in patients with cancer, may be due to both primary thoracic tumours or to a metastatic spread in the chest and constitutes the first sign of disease in approximately 10% of patients. Almost all cancers can potentially produce a pleural effusion. The presence of malignant tumour cells in the pleural fluid is generally indicative of advanced disease and is associated with high morbidity and mortality with reduced therapeutic options. Read More

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http://dx.doi.org/10.2174/1574887114666181204105208DOI Listing
January 2019
3 Reads

Hair Loss Prevention by a Scalp Cooling Device in Early Breast Cancer Patients: The Poliambulanza Preliminary Experience.

Rev Recent Clin Trials 2019 ;14(1):66-71

Medical Oncology Unit, Fondazione Poliambulanza, Brescia, Italy.

Background: The most effective agents in the treatment of breast cancer have a common side effect, the hair loss. Some studies reported a reduction of hair loss with the use of the scalp cooling device. Indeed, it decreases the drug accumulation in the hair follicles. Read More

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http://dx.doi.org/10.2174/1574887113666181120111104DOI Listing
January 2019
19 Reads

Association Between Pulmonary Hypertension and Transcatheter Aortic Valve Replacement: Analysis of a Nationwide Inpatient Sample Database.

Rev Recent Clin Trials 2019 ;14(1):56-60

Department of Cardiology, St. Joseph Mercy Oakland Hospital, 44405 Woodward Ave, Pontiac, MI 48341, United States.

Introduction: This study was done to review the association of pulmonary hypertension (PH) with Transcatheter Aortic Valve Replacement (TAVR) procedures done in the US for years 2010 to 2012.

Methods: We used Nationwide Inpatient Sample (NIS) data to extract data for patients who were hospitalized with a primary/secondary diagnosis of TAVR as specified by International Classification of Disease (ICD-9) codes 35.05 and 35. Read More

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http://dx.doi.org/10.2174/1574887113666181120113034DOI Listing
January 2019
12 Reads

Effect of Chondroitin Sulfate on Blood Serum Cytokine Profile during Carrageenan-induced Edema and Monoiodoacetate-induced Osteoarthritis in Rats.

Rev Recent Clin Trials 2019 ;14(1):50-55

Department of Biochemistry, Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.

Background: Blood cytokines affect the development of inflammatory processes in both normal and pathological states. We have studied changes in the concentration of interleukins (ILs) - 1β, IL-4, IL-10, IL-12B p40, transforming growth factor β (TGF β), tumor necrosis factor (TNF-α) in acute carrageenan-induced inflammation and degenerative-dystrophic changes of knee joint caused by monoiodoacetate-induced Osteoarthritis (OA) in experimental models on rats. We also investigated the change in the cytokine profile during prophylactic and therapeutic administration of chondroitin sulfate to animals under experimental conditions. Read More

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http://dx.doi.org/10.2174/1574887113666181102111247DOI Listing
January 2019
2 Reads

Rosmarinic Acid as Potential Anti-Inflammatory Agent.

Rev Recent Clin Trials 2018 ;13(4):240-242

Department of Health Sciences, University "Magna Graecia" of Catanzaro, Campus "Salvatore Venuta", 88100 Germaneto, Catanzaro, Italy.

Rosmarinus officinalis L. (Lamiaceae), popularly known as rosemary, is used for food flavoring, and in folk medicine, as an antispasmodic, analgesic, anti-rheumatic, diuretic, and antiepileptic agent. Rosemary is an herb widely used in folk medicine, cosmetics, and phytotherapy and for flavoring of food products. Read More

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http://dx.doi.org/10.2174/157488711304180911095818DOI Listing
January 2018
9 Reads

Effect of Kangaroo Mother Care on Successful Breastfeeding: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Rev Recent Clin Trials 2019 ;14(1):31-40

Tabriz Health Services Management Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Background & Aims: Evaluating the effect of Kangaroo Mother Care (KMC) on breastfeeding success shows conflicting results. Regarding the importance of breastfeeding and uncertainties about its effect, this study intended to conduct a systematic review and meta-analysis of randomised controlled trials on the effect of KMC on success of breastfeeding.

Methods: In this systematic review and meta-analysis study, required data were collected by searching the following keywords: breastfeeding, Breast-Feeding, "skin-to-skin", "Kangaroo Mother Care", randomized clinical trial. Read More

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http://dx.doi.org/10.2174/1574887113666180924165844DOI Listing
January 2019
3 Reads

A Review of Clinical Data Management Systems Used in Clinical Trials.

Rev Recent Clin Trials 2019 ;14(1):10-23

Department of Epidemiology, School of Health, Iran University of Medical Sciences, Tehran, Iran.

Background: A clinical data management system is a software supporting the data management process in clinical trials. In this system, the effective support of clinical data management dimensions leads to the increased accuracy of results and prevention of diversion in clinical trials. The aim of this review article was to investigate the dimensions of data management in clinical data management systems. Read More

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http://dx.doi.org/10.2174/1574887113666180924165230DOI Listing
January 2019
2 Reads

A Concise History of Thiopurines for Inflammatory Bowel Disease: From Anecdotal Reporting to Treat-to-Target Algorithms.

Rev Recent Clin Trials 2019 ;14(1):4-9

Department of Medical Sciences, University of Turin, Turin, Italy.

Background: The need for immune suppressive strategies in the control of chronic inflammatory bowel diseases originated in the 1960s following the perception of a relative inefficacy of salazopyrin and its derivatives. In some 50 years upon an anecdotal claim, the indication for thiopurines in the management of inflammatory bowel diseases has come of age.

Objective: The aim of this minireview is to give an overview, after the historical premises, of the current use of thiopurines in the context of inflammatory bowel diseases. Read More

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http://dx.doi.org/10.2174/1574887113666180910120959DOI Listing
January 2019
23 Reads

The Management of Newly Diagnosed HIV in a Sudanese Refugee in Canada: Commentary and Review of Literature.

Rev Recent Clin Trials 2019 ;14(1):61-65

Vancouver Virology Centre, Vancouver, Canada.

Background: Human Immunodeficiency Virus (HIV) prevalence rates in refugee camps are inconclusive in current literature, with some studies highlighting the increased risk of transmission due to poor living conditions and lower levels of education. With the increasing number of refugees from HIV endemic countries, it is important to assess the programs established to support patients upon arrival. Refugees have been reported to have a lower health literacy and face disease-related stigmatization, which must be overcome for the lifelong treatment of HIV. Read More

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http://dx.doi.org/10.2174/1574887113666180903145323DOI Listing
January 2019
13 Reads

Gender Differences in Types, Frequency, Clinical Manifestations and Atherosclerotic Burden of Coronary Artery Anomalies.

Rev Recent Clin Trials 2019 ;14(1):41-46

Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland.

Background: Although not well established; gender may play a role in the incidence, clinical manifestations, and atherosclerotic burden of Coronary Artery Anomalies (CAAS). Our aim is to investigate the impact of gender on coronary artery anomalies.

Methods: All coronary angiograms performed at the University Heart Center Zurich, Switzerland, between January 2000 and December 2016 were investigated. Read More

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http://dx.doi.org/10.2174/1574887113666180820111341DOI Listing
January 2019
9 Reads

Prevention of Infection in Adults Receiving Intravenous Antibiotic Treatment via Indwelling Central Venous Access Devices.

Rev Recent Clin Trials 2019 ;14(1):47-49

Breakspear Medical Group, Hemel Hempstead, Hertfordshire, United Kingdom.

Background: The use of indwelling Central Venous Access Devices (CVADs) is associated with the development of bloodstream infections. When CVADs are used to administer systemic antibiotics, particularly second- or higher-generation cephalosporins, there is a particular risk of developing Clostridium difficile infection. The overall bloodstream infection rate is estimated to be around 1. Read More

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http://dx.doi.org/10.2174/1574887113666180817125036DOI Listing
January 2019
12 Reads

Cardiometabolic Comorbidities in Autoimmune Rheumatic Diseases: From Pathogenesis to Treatment.

Rev Recent Clin Trials 2018;13(3):162-163

Rheumatology Section, Department of Biotechnological and Applied Clinical Sciences, University of L`Aquila, L`Aquila, Italy.

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http://dx.doi.org/10.2174/157488711303180712162841DOI Listing
December 2018
2 Reads

Successful Use of Aliskiren in a Case of IgA- Mesangial Glomerulonephritis Unresponsive to Conventional Therapies.

Rev Recent Clin Trials 2019 ;14(1):72-76

Nephrology Unit, University Hospital 'Magna Graecia', Department of Medical and Surgical Sciences, Catanzaro, Italy.

Introduction: The early suspension of Altitude trial in recent years has induced most nephrologists and cardiologists to abandon Aliskiren use. Consequently, the potential usefulness of the direct renin inhibition in IgA glomerulonephritis remained an under-investigated therapeutic option.

Case Report: We report the case of a 53 years old IgA GMN patient unresponsive to all conventional anti-angiotensin-2 agents, steroids and immunosuppressants, in which the administration of Aliskiren permitted to achieve and maintain a complete proteinuria remission in the absence of any adverse event. Read More

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http://dx.doi.org/10.2174/1574887113666180726103648DOI Listing
January 2019
7 Reads

Trends in Vena Cava Filter Placement: An Analysis of Nationwide Inpatient Sample Database Over an 11 Year Period.

Rev Recent Clin Trials 2018 ;13(4):305-311

Department of Internal Medicine, Western Michigan University Homer Stryker School of Medicine, Kalamazoo, MI, United States.

Objectives: There have been increasing concerns regarding inappropriate usage of vena caval filters. Our study was done to analyze the current trends in vena caval filter placement.

Methods: This study used the data from Nationwide Inpatient Sample database for the years 2002- 2012 to identify patients with vena caval filter placement. Read More

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http://dx.doi.org/10.2174/1574887113666180626161130DOI Listing
January 2018
9 Reads

Association Between Delayed Graft Function (DGF) Biomarkers and Long-term Outcomes After Living Donor Kidney Transplantation.

Rev Recent Clin Trials 2018 ;13(4):312-318

Department of Clinical Pharmacy, School of Pharmacy, Shohadaye-7 Tir Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background And Objectives: The association between preoperative Urine Neutrophil Gelatinase-associated Lipocalin (uNGAL) and interleukin-18 (uIL-18) with poor 1-year allograft function has been shown in deceased-donor kidney transplant recipients previously, and also these markers could predict 3-month allograft function. However, it is unknown whether there is an association between these postoperative biomarkers with important recipient outcomes beyond this time in livedonor transplants.

Methods: NGAL and IL-18 four and 24 hours were measured in live-donor kidney transplant recipients after transplantation. Read More

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http://dx.doi.org/10.2174/1574887113666180522082930DOI Listing
January 2018
4 Reads

Risk Factors for Prolonged Postoperative Ileus in Adult Patients Undergoing Elective Colorectal Surgery: An Observational Cohort Study.

Rev Recent Clin Trials 2018 ;13(4):295-304

Department of Surgery II, San Paolo Hospital, University of Milan, Via A di Rudinì 8, I-20142 Milan, Italy.

Purpose: Prolonged Postoperative Ileus (PPOI) after abdominal surgery may affect unfavourably the patient recovery. The aim of this study was to estimate the incidence of PPOI in patients elective for colorectal resection and investigate perioperative variables associated with PPOI.

Methods: A consecutive series of 428 patients undergoing colorectal resection (median age 72, range 24-92, years; men/women ratio 1. Read More

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http://dx.doi.org/10.2174/1574887113666180521111153DOI Listing
January 2018
7 Reads

TGN-1412 and BIA-2474 Trials with Tragic End: Lessons Learnt To Make Clinical Trials Safer.

Rev Recent Clin Trials 2018 ;13(4):252-256

Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, India.

Background: Globally, there have been tremendous efforts by regulatory authorities to make clinical trials safer by making stringent clinical trial regulations. Despite this, we witnessed several tragic events. TGN1412 and BIA 10-2474 phase I trials are infamous trails in which healthy volunteers either succumbed to severe adverse effects or faced irreversible impairments of the test drug. Read More

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http://dx.doi.org/10.2174/1574887113666180521093529DOI Listing
January 2018
15 Reads

Biochemical and Haematological Predictors of Reduced Neutrophil Granulocyte Count associated with Intravenous Ceftriaxone Treatment.

Rev Recent Clin Trials 2018 ;13(4):287-294

Breakspear Medical Group, Hemel Hempstead, Hertfordshire, United Kingdom.

Background: Intravenous treatment with ceftriaxone, a commonly used third-generation cephalosporin, is associated with a risk of the potentially fatal side-effect of neutropenia.

Objective: The first systematic study to determine whether six to 12 days' intravenous ceftriaxone treatment is associated with a reduction in the neutrophil count and the extent to which biochemical and/or haematological parameters routinely measured at baseline predict such a fall.

Method: Baseline and follow-up haematological and biochemical blood indices were measured in 86 patients (mean age 39. Read More

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http://dx.doi.org/10.2174/1574887113666180517072744DOI Listing
January 2018
3 Reads

Atrial Fibrillation in Autoimmune Rheumatic Diseases: from Pathogenesis to Treatment.

Rev Recent Clin Trials 2018;13(3):170-175

Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milano, Italy.

Atrial Fibrillation (AF) is the most commonly described cardiac arrhythmia found in the general population and can lead to adverse outcomes. Its onset and maintenance requires the presence of an arrhythmogenic substrate that predisposes the patient for risk of these types of arrhythmias and the occurrence of a trigger event. A major characteristic of AF-related structural remodelling is atrial fibrosis, a process closely related to inflammation. Read More

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http://dx.doi.org/10.2174/1574887113666180418110721DOI Listing
December 2018
7 Reads

Efficacy of Transcranial Direct Current Stimulation Combined with Cognitive Training in the Treatment of Apathy in Patients with Alzheimer's Disease: Study Protocol for a Randomized Trial.

Rev Recent Clin Trials 2018 ;13(4):319-327

Service de geriatrie, CHU hopital Bellier, 44000 Nantes, France.

Background: Apathy, commonly defined as the loss of motivation, is a symptom frequently encountered in Alzheimer's Disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial Magnetic Stimulation (rTMS) or Transcranial Direct Current Stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Read More

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http://dx.doi.org/10.2174/1574887113666180416153316DOI Listing
January 2018
4 Reads

Role of Point-of-Care Ultrasonography for the Management of Sepsis and Septic Shock.

Rev Recent Clin Trials 2018 ;13(4):243-251

Department of Critical Care Medicine, Manipal Hospital, Dwarka, New Delhi, India.

Background: Sepsis and septic shock remain a major cause of morbidity and mortality globally. In recent years, the outcome of patients with sepsis and septic shock has gradually improved, in part due to early recognition and timely appropriate management. Bedside physical examination can be of limited value to identify the source of infection and to decide appropriate management. Read More

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http://dx.doi.org/10.2174/1574887113666180412165405DOI Listing
January 2018
2 Reads

Clinical Significance of Anti-Ribosomal P Protein Antibodies in Patients with Lupus Nephritis.

Rev Recent Clin Trials 2018 ;13(4):281-286

Department of Immunology & Molecular Biology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

Background: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disorder affecting multiple systems of the body. Clinical features show wide variations in patients with the different ethnic background. Renal involvement is a predictor of poor prognosis. Read More

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http://www.eurekaselect.com/161136/article
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http://dx.doi.org/10.2174/1574887113666180409154641DOI Listing
January 2018
4 Reads

Overall and Multiphasic Findings of the Prostate, Lung, Colorectal and Ovarian (PLCO) Randomized Cancer Screening Trial.

Rev Recent Clin Trials 2018 ;13(4):257-273

National Institutes of Health, Bethesda, MD, United States.

Background: Screening tests are typically evaluated for a single disease, but multiple tests for multiple diseases are performed in practice. The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial assessed testing for four cancers simultaneously and can be viewed as a multiphasic cancer intervention. This paper presents overall and multiphasic findings of this trial. Read More

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http://dx.doi.org/10.2174/1574887113666180409153059DOI Listing
January 2018
4 Reads

Impact of a Psycho-Educational Team in early Breast Cancer Patients' Coping Strategies: The Venere Project.

Rev Recent Clin Trials 2018 ;13(4):274-280

Oncology Department, Fondazione Poliambulanza, Brescia, Italy.

Aims And Background: The main purpose of our psycho-educational groups was to help women with breast cancer, learn how to cope with the physical, emotional, and lifestyle changes associated with cancer as well as with medical treatments that can be painful and traumatic. With this study, we wanted to detect the effects that group action had on the women who participated in it.

Methods: We studied a total of 97 patients who participated in 13 psycho-education groups. Read More

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http://dx.doi.org/10.2174/1574887113666180409152025DOI Listing
January 2018
18 Reads

Treatment of Metastatic, Castration-resistant, Docetaxel-resistant Prostate Cancer: A Systematic Review of Literature With a Network Meta-analysis of Randomized Clinical Trials.

Rev Recent Clin Trials 2018;13(3):226-237

Department of Internal Medicine, Arcispedale S. Anna, Ferrara, Italy.

Introduction: To compare the efficacy of abiraterone acetate, enzalutamide, cabazitaxel and Radium-223 in the treatment of castration-resistant, docetaxel-resistant metastatic prostate cancer.

Methods: An indirect comparison of Overall Survival (OS) and time to PSA progression among abiraterone acetate, enzalutamide, cabazitaxel and Radium-223 was performed with a network metaanalysis. OS in the entire population of patients was the primary endpoint. Read More

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http://www.eurekaselect.com/160980/article
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http://dx.doi.org/10.2174/1574887113666180404120540DOI Listing
December 2018
7 Reads

Association Between Hypothyroidism and Takotsubo Cardiomyopathy: Analysis of Nationwide Inpatient Sample Database.

Rev Recent Clin Trials 2018 ;13(3):222-225

Department of Cardiology, Michigan State University/ Borgess Medical Center, 1521 Gull Rd, Kalamazoo, MI 49048, United States.

Background: Takotsubo Cardiomyopathy (TC), also called transient left ventricular (LV) ballooning syndrome, resembles myocardial infarction and is characterized by LV dysfunction in the absence of coronary artery disease. Hypothesis described for TC has been an intense social stressor, pheochromocytoma, thyrotoxicosis among others. We performed this study to analyze the association of hypothyroidism with TC. Read More

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http://dx.doi.org/10.2174/1574887113666180402144600DOI Listing
December 2018
8 Reads

The Use of Probiotics in Different Phases of Diverticular Disease.

Rev Recent Clin Trials 2018;13(2):89-96

Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli, Catholic University of Rome, Rome, Italy.

Background & Aims: Diverticular Disease (DD) is a common clinical condition with a dramatic increasing of the prevalence among industrialized countries. Based on the most used classification, DD may be divided into asymptomatic diverticulosis, symptomatic uncomplicated diverticular disease and complicated diverticular disease. Since recent studies pointed out the role of GUT microbiota imbalance in promoting diverticular formation and inflammation, we have designed a systematic review focusing on the possible role of probiotics in the management of this condition. Read More

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http://dx.doi.org/10.2174/1574887113666180402143140DOI Listing
December 2018
6 Reads

Impact of Primary Tumor Location on First-line Bevacizumab or Cetuximab in Metastatic Colorectal Cancer.

Rev Recent Clin Trials 2018;13(2):139-149

Brown University Oncology Group, Providence, RI, United States.

Background: Colorectal cancer is one of the most common malignancies in the United States, with a large proportion of patients presenting with metastatic disease or developing a recurrence. Systemic chemotherapy is the mainstay of therapy in this setting. There is a clear benefit in the addition of bevacizumab or cetuximab (for rat sarcoma [RAS] wild type tumors) to oxaliplatin- and irinotecan-based regimens which can be considered for first-line therapy. Read More

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http://www.eurekaselect.com/160800/article
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http://dx.doi.org/10.2174/1574887113666180328104109DOI Listing
December 2018
7 Reads

Dyspnea in Cancer Patients: A Well-Known and Neglected Symptom.

Authors:
Fausto Meriggi

Rev Recent Clin Trials 2018;13(2):84-88

Oncology Department, Poliambulanza, Via Leonida Bissolati 57, 25124, Brescia, Italy.

Background: Dyspnea is a very common and well-known symptom in patients with advanced cancer, but it is often neglected by physicians. Moreover, despite the high frequency of dyspnea, few controlled studies have been conducted on cancer patients. In most cases, this 'awareness of breathing with difficulty' and its severity can only be judged by the patient. Read More

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http://dx.doi.org/10.2174/1574887113666180326112116DOI Listing
December 2018
3 Reads

Arnica compositum, Hekla lava and Acidum Nitricum Together are Superior to Arnica compositum Alone in the Local Treatment of Symptomatic Calcific Periarthritis of the Shoulder: A Pilot Study.

Rev Recent Clin Trials 2018;13(2):150-155

Department of Surgery, Oncology & Gastroenterology, University of Padua, School of Medicine, Via Giustiniani 2, 35128 Padova, Italy.

Background: To evaluate the usefulness of Arnica compositum (AC) + Acidum nitricum (AN) + Hekla lava (HL) ointment in Emergency Medicine Department (EMD) as alternative nonpharmacological local treatment of patients with symptomatic calcific periarthritis of the shoulder (CPS) and to compare the effectiveness of this mixture against AC ointment alone.

Methods: A series of 41 consecutive patients (20 women, 19 men, median age 49 years, range 25-80 years) with non-traumatic painful unilateral CPS were randomly assigned to receive local treatment with AC+AN+HL ointment mixture (Group A, cases, N=21) or AC ointment alone (Group B, controls, N=20). The radiological Gartner classification of the CPS, and the quantification of pre- and post-treatment pain intensity using a Visual Analogue Scale (VAS) were obtained. Read More

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http://dx.doi.org/10.2174/1574887113666180319165700DOI Listing
December 2018
9 Reads

The Emerging Role of IL-1 Inhibition in Patients Affected by Rheumatoid Arthritis and Diabetes.

Rev Recent Clin Trials 2018;13(3):210-214

Rheumatology Section, Department of Biotechnological and Applied Clinical Sciences, University of L`Aquila, L`Aquila, Italy.

Background: Although in the past, prevention of the joint destruction and disability was strongly emphasised in Rheumatoid Arthritis (RA), at present, a growing body of evidence is focused at identifying the best management of associated comorbidities, such as Type 2 Diabetes (T2D). Recently, the hypothesis that blocking pro-inflammatory activity may be helpful in the treatment of some comorbidities has been proposed in RA patients.

Objective: We reviewed the role of IL-1β during RA and T2D, the efficacy of IL-1 blocking agents in controlling both diseases and, possible, decreasing the concomitant enhanced atherosclerotic process. Read More

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http://dx.doi.org/10.2174/1574887113666180314102651DOI Listing
December 2018
34 Reads

Serum Complement C3 and Type 2 Diabetes in Rheumatoid Arthritis: A Case-Control Study.

Rev Recent Clin Trials 2018;13(3):215-221

Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.

Background: Recent evidence demonstrated a potential role of complement C3 as a candidate biomarker of cardiometabolic risk in the general population.

Objective: Aim of the present study was to investigate the correlation between complement C3 levels and comorbid Type 2 Diabetes (T2DM) in Rheumatoid Arthritis (RA) patients.

Methods: For the present study, 40 consecutive diabetic RA patients (RA/T2DM+ group) and 80 consecutive RA patients without diabetes (RA/T2DM- group) were recruited. Read More

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http://dx.doi.org/10.2174/1574887113666180314092757DOI Listing
December 2018
7 Reads

Insulin-Sensiting Effects of Tumor Necrosis Factor Alpha Inhibitors in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Rev Recent Clin Trials 2018;13(3):184-191

Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.

Background: Rheumatoid Arthritis (RA) has been associated with insulin resistance (IR), a well-established pathophysiological feature of Type 2 Diabetes (T2DM). Inconsistent literature evidence suggests that IR could be ameliorated by biological medications targeting TNFα.

Objective: The aim of this systematic review was to evaluate the effect of TNFα inhibitors (TNFi) on IR in RA patients. Read More

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http://dx.doi.org/10.2174/1574887113666180314100340DOI Listing
December 2018
7 Reads

Endothelial Dysfunction in Systemic Lupus Erythematosus: Pathogenesis, Assessment and Therapeutic Opportunities.

Rev Recent Clin Trials 2018;13(3):192-198

Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.

Background: Systemic Lupus Erythematosus (SLE) is characterised by increased mortality secondary to Cardiovascular Diseases (CVD). Despite being common in SLE, traditional cardiovascular risk factors cannot entirely justify such increase in CVD-associated mortality. The endothelium is a key regulator of the vascular homeostasis; lupus-associated persistent systemic inflammation may impair endothelium functionality, thus initiating a cascade of events that, in concert with traditional CVD-risk factors, leads to atherosclerosis development and progression. Read More

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http://dx.doi.org/10.2174/1574887113666180314091831DOI Listing
December 2018
3 Reads

Diabetic Ketoacidosis in Patients with Type 2 Diabetes on Sodium-Glucose Cotransporter-2 Inhibitors - A Case Series.

Rev Recent Clin Trials 2018;13(2):156-160

Department of Internal Medicine, University of Miami Palm Beach Regional Consortium, Atlantis, FL, United States.

Background: Diabetic ketoacidosis (DKA) is a serious complication of diabetes seen commonly in autoimmune Type 1 diabetes mellitus (DM), however patients with Type 2 diabetes are also at risk. Diabetic ketoacidosis may be precipitated by the catabolic stress of acute illness such as trauma, surgery, or infections. Recent studies have suggested that sodium-glucose cotransporter-2 (SGLT-2) inhibitors precipitate DKA in Type 2 diabetes. Read More

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http://dx.doi.org/10.2174/1574887113666180314101436DOI Listing
December 2018
9 Reads

Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients.

Rev Recent Clin Trials 2018 ;13(3):199-209

Department of Clinical Medicine and Surgery - Rheumatology Research Unit - Federico II University, Naples, Italy.

Background: Psoriatic arthritis is a chronic inflammatory arthropathy that affects 14%- 30% of patients with skin and/or nail psoriasis, leading to severe physical limitations and disability. It has been included in the group of spondyloarthropathy with which it shares clinical, radiologic, and serologic features in addition to familial and genetic relationship. Beyond skin and joint involvement, psoriatic arthritis is characterized by a high prevalence of extra-articular manifestation and comorbidities, such as autoimmune, infectious and neoplastic diseases. Read More

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http://dx.doi.org/10.2174/1574887113666180314105511DOI Listing
December 2018
7 Reads

Bariatric Surgery and Rheumatic Diseases: A Literature Review.

Rev Recent Clin Trials 2018;13(3):176-183

Department of Medical and Surgical Sciences, O.U. of General Surgery, University of Catanzaro, Catanzaro, Italy.

Background: Obesity is a debilitating growing condition and represents a challenge for every surgeon. It is associated with the activation of the inflammatory pathway and this may have a negative impact on the natural history of some rheumatic diseases. Bariatric surgery, reducing obesity, could bring to a minor activation of the well-known inflammatory pathway with improvement of these diseases. Read More

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http://dx.doi.org/10.2174/1574887113666180314095445DOI Listing
December 2018
8 Reads

Cardiovascular Disease in Primary Sjögren's Syndrome.

Rev Recent Clin Trials 2018;13(3):164-169

Division of Rheumatology, University of L`Aquila, L`Aquila, Italy.

Background: A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjögren's syndrome (pSS) experienced an increased risk of CVD.

Objective: This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients. Read More

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http://dx.doi.org/10.2174/1574887113666180315130336DOI Listing
December 2018
10 Reads

Evaluating the Effect of Oral N-acetylcysteine as an Adjuvant Treatment on Clinical Outcomes of Patients with Rheumatoid Arthritis: A Randomized, Double Blind Clinical Trial.

Rev Recent Clin Trials 2018 ;13(2):132-138

Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: Oxidative stress and Overproduction of pro-inflammatory cytokines are contributed in Rheumatoid Arthritis (RA) pathogenesis. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent which demonstrated analgesic effects in some studies. This study is designed to assess the effects of oral NAC as an adjuvant therapy on the clinical outcomes of patients with active RA. Read More

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http://dx.doi.org/10.2174/1574887113666180307151937DOI Listing
December 2018
14 Reads

Pharmacology, Systematic Review and Recent Clinical Trials of Metadoxine.

Rev Recent Clin Trials 2018;13(2):114-125

Department of Neuropharmacology, Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester, LE1 9BH, United Kingdom.

Background: Metadoxine is composed of pyroglutamic acid and vitamin B6. Administrations of metadoxine are indicated in cases of acute alcohol intoxication or in chronic alcoholism.

Objectives: To reference all available clinical trials investigating the effects of metadoxine on humans. Read More

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http://dx.doi.org/10.2174/1574887113666180227100217DOI Listing
December 2018
35 Reads