775 results match your criteria Reviews in Medical Virology[Journal]


Role of iron in cancer development by viruses.

Rev Med Virol 2019 Apr 17:e2045. Epub 2019 Apr 17.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Increased levels of iron in body are attributed to higher cancer risk. Given the fact that 16% of all human cancers are caused by viral infections, iron is suggested to play an important role in carcinogenesis particularly those induced by viral infections. The present study provides an updated summary of the literature and the plausible mechanisms of iron involvement in cancer development by viruses. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rmv.2045
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April 2019
1 Read

BK virus: Current understanding of pathogenicity and clinical disease in transplantation.

Rev Med Virol 2019 Apr 8:e2044. Epub 2019 Apr 8.

Department of Renal Medicine, Royal Free Hospital, University College London, London, UK.

BK polyomavirus (BKV) is an important cause of graft loss in renal transplant recipients that continues to pose a significant challenge to clinicians due to its frequently unpredictable onset, persistence, and the lack of effective antiviral agents or prevention strategies. This review covers our current understanding of epidemiology, viral transmission and disease progression, and treatment and prevention strategies that have been used to manage this disease. Read More

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April 2019
1 Read

Marine glycan-based antiviral agents in clinical or preclinical trials.

Rev Med Virol 2019 Apr 3:e2043. Epub 2019 Apr 3.

Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao, PR China.

The constant outbreak of diseases caused by viral infections has caused serious harm to human health all over the world. Although many antiviral drugs have been approved for clinical use during the past decade, important issues, such as unsatisfactory efficacy, toxicity, and high cost of drugs, remain unresolved. Glycans are major components of the surfaces of both host cells and most viruses and play critical roles in the steps of viral infection. Read More

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http://dx.doi.org/10.1002/rmv.2043DOI Listing
April 2019
2 Reads
5.574 Impact Factor

Current weight of evidence of viruses associated with peri-implantitis and peri-implant health: A systematic review and meta-analysis.

Rev Med Virol 2019 Mar 22:e2042. Epub 2019 Mar 22.

Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.

The pathological role of human herpesviruses (HHVs) (Epstein-Barr virus [EBV], Human cytomegalovirus [CMV], and Herpes simplex virus [HSV]) in peri-implant health needs clarification quantitatively. To determine the weight of evidence for HHVs in patients with peri-implantitis (PI) and substantiate the significance of HHVs in peri-implant inflammation, electronic databases including EMBASE, MEDLINE, Cochrane Oral Health Group Trials Register, and Cochrane Central Register of Controlled Trials were searched from 1964 up to and including November 2018. Meta-analyses were conducted for prevalence of HHVs in PI and healthy controls. Read More

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http://dx.doi.org/10.1002/rmv.2042DOI Listing
March 2019
2 Reads
5.574 Impact Factor

Annexin A2 extracellular translocation and virus interaction: A potential target for antivirus-drug discovery.

Rev Med Virol 2019 Feb 11:e2038. Epub 2019 Feb 11.

Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Science, University Putra Malaysia, Seri Kembangan, Malaysia.

Annexin A2 is a membrane scaffolding and binding protein, which mediated various cellular events. Its functions are generally affected by cellular localization. In the cytoplasm, they interacted with different phospholipid membranes in Ca -dependent manner and play vital roles including actin binding, remodeling and dynamics, cytoskeletal rearrangement, and lipid-raft microdomain formation. Read More

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February 2019
8 Reads

Structural and functional similarities in bunyaviruses: Perspectives for pan-bunya antivirals.

Rev Med Virol 2019 Feb 11:e2039. Epub 2019 Feb 11.

Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium.

The order of Bunyavirales includes numerous (re)emerging viruses that collectively have a major impact on human and animal health worldwide. There are no vaccines for human use or antiviral drugs available to prevent or treat infections with any of these viruses. The development of efficacious and safe drugs and vaccines is a pressing matter. Read More

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http://dx.doi.org/10.1002/rmv.2039DOI Listing
February 2019
6 Reads

Turning cost effectiveness analysis on its head.

Authors:
Paul D Griffiths

Rev Med Virol 2019 Mar 7;29(2):e2040. Epub 2019 Feb 7.

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March 2019
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Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis.

Rev Med Virol 2019 Jan 31:e2034. Epub 2019 Jan 31.

Department of Virology, Royal Free NHS Foundation Trust, London, UK.

Cytomegalovirus (CMV) infection does not usually produce symptoms when it causes primary infection, reinfection, or reactivation because these three types of infection are all controlled by the normal immune system. However, CMV becomes an important pathogen in individuals whose immune system is immature or compromised, such as the unborn child. Several vaccines against CMV are currently in clinical trials that aim to induce immunity in seronegative individuals and/or to boost the immunity of those with prior natural infection (seropositives). Read More

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January 2019
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Is tetherin a true antiviral: The influenza a virus controversy.

Rev Med Virol 2019 Jan 31:e2036. Epub 2019 Jan 31.

School of Science, Monash University, Sunway Campus, Bandar Sunway, Malaysia.

Tetherin, an interferon-inducible gene was first discovered to be an antiviral factor in 2008. A vast range of viruses, such as influenza A virus (IAV), dengue virus, Ebola virus, HIV, and RSV, have been reported to be susceptible to the antiviral activity of tetherin. Multiple reports have been published encompassing the role of tetherin in the IAV life cycle. Read More

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http://dx.doi.org/10.1002/rmv.2036DOI Listing
January 2019
6 Reads

Rotavirus VP6 as a potential vaccine candidate.

Rev Med Virol 2019 Mar 6;29(2):e2027. Epub 2019 Jan 6.

Virology Department, Pasteur Institute of Iran, Tehran, Iran.

By the age of 5 years, virtually all children have been infected by group A rotavirus (RVA), which is responsible for around half million mortality annually prior to vaccination. Relatively high rate of the morbidity and mortality highlights the necessity of applying preventive procedures particularly in developing countries. Two live attenuated RVA vaccines (Rotarix and RotaTeq) are licensed and now being used in many countries worldwide. Read More

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http://doi.wiley.com/10.1002/rmv.2027
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March 2019
12 Reads

Hepatitis C virus protein interaction network for HCV clearance and association of DAA to HCC occurrence via data mining approach: A systematic review and critical analysis.

Rev Med Virol 2019 Mar 6;29(2):e2033. Epub 2019 Jan 6.

University of Tunis El Manar, Biology department, Tunish, Tunisia.

HCV has been associated with a pro-inflammatory state, which predisposes to hepatocellular carcinoma (HCC). However, the different molecular mechanisms underlying the effect of HCV infection on HCC progression remain unclear. Although HCV infection illustrates the potential role of host genetics in the outcome of infectious diseases, there is no clear overview of some single nucleotide polymorphisms (SNPs) influencing spontaneous or treatment-induced HCV eradication. Read More

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http://dx.doi.org/10.1002/rmv.2033DOI Listing
March 2019
2 Reads
5.574 Impact Factor

The interplay between vitamin D and viral infections.

Rev Med Virol 2019 Mar 6;29(2):e2032. Epub 2019 Jan 6.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

The pleiotropic role of vitamin D has been explored over the past decades and there is compelling evidence for an epidemiological association between poor vitamin D status and a variety of diseases. While the potential anti-viral effect of vitamin D has recently been described, the underlying mechanisms by which vitamin D deficiency could contribute to viral disease development remain poorly understood. The possible interactions between viral infections and vitamin D appear to be more complex than previously thought. Read More

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http://dx.doi.org/10.1002/rmv.2032DOI Listing
March 2019
2 Reads

Expressional activation and functional roles of human endogenous retroviruses in cancers.

Rev Med Virol 2019 Mar 6;29(2):e2025. Epub 2019 Jan 6.

Cancer Institute, Second Affiliated Hospital, and Ministry of Education Key Laboratory of Cancer Prevention and Intervention, Zhejiang University School of Medicine, Hangzhou, China.

Human endogenous retroviruses (HERVs) are widely believed to be remnants of ancestral germ line infections by exogenous retroviruses. Although HERVs are deemed as "nonfunctional DNAs" due to loss of most of their viral protein coding capacity during evolution as part of the human genome, cumulative evidences are showing the expressional activation and potential roles of HERVs in diseases especially cancers. Work by other researchers and us has observed the dysregulation of HERVs in cancers, identified new HERV-related genes, and revealed their potential importance in cancer development. Read More

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http://doi.wiley.com/10.1002/rmv.2025
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March 2019
16 Reads

The interplay between viruses and TRIM family proteins.

Rev Med Virol 2019 Mar 4;29(2):e2028. Epub 2019 Jan 4.

Molecular Virology Laboratory, Centre for Applied Molecular Biology (CAMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan.

Novel therapeutic options are urgently needed to improve the global treatment of viral infections. Tripartite motif (TRIM) family proteins are involved in various biological and cellular functions including differentiation, development, proliferation, oncogenesis, innate immunity, and viral autophagy. Various TRIM proteins show antiviral properties against different viral infections and are now transitioning from ubiquitin proteins to an efficient and emerging therapeutic class of proteins. Read More

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http://doi.wiley.com/10.1002/rmv.2028
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March 2019
3 Reads

Tat basic domain: A "Swiss army knife" of HIV-1 Tat?

Rev Med Virol 2019 Mar 4;29(2):e2031. Epub 2019 Jan 4.

LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, CNRS, Villejuif, France.

Tat (transactivator of transcription) regulates transcription from the HIV provirus. It plays a crucial role in disease progression, supporting efficient replication of the viral genome. Tat also modulates many functions in the host genome via its interaction with chromatin and proteins. Read More

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http://dx.doi.org/10.1002/rmv.2031DOI Listing
March 2019
2 Reads

Disease severity in respiratory syncytial virus infection: Role of host genetic variation.

Rev Med Virol 2019 Mar 4;29(2):e2026. Epub 2019 Jan 4.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs only in a minority of the population. There are many factors (host, viral, and environmental) that contribute to the complicated disease phenotype. Read More

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http://doi.wiley.com/10.1002/rmv.2026
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March 2019
9 Reads
5.574 Impact Factor

Systematic review of spontaneous splenic rupture in dengue-infected patients.

Rev Med Virol 2019 Mar 4;29(2):e2029. Epub 2019 Jan 4.

Evidence Based Medicine Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Dengue infection varies from a mild febrile form to more severe disease with plasma leakage, shock, and multiorgan failure. Several serious complications such as cardiomyopathy, encephalopathy, encephalitis, hepatic damage, and neural manifestations cause organ damage in dengue infection. Splenic rupture, a less well known but life-threatening complication, can occur in dengue. Read More

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http://dx.doi.org/10.1002/rmv.2029DOI Listing
March 2019
4 Reads

Influenza: the centennial of a zoonosis.

Rev Med Virol 2019 01 21;29(1):e2030. Epub 2018 Dec 21.

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http://dx.doi.org/10.1002/rmv.2030DOI Listing
January 2019
1 Read

Systematic review of ganciclovir pharmacodynamics during the prevention of cytomegalovirus infection in adult solid organ transplant recipients.

Rev Med Virol 2019 Mar 17;29(2):e2023. Epub 2018 Dec 17.

Serology and Virology Division, NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.

Human cytomegalovirus (CMV) represents the most common infection among recipients of solid organ transplants (SOTs). Previous meta-analysis showed 0.8% of SOT recipients developed CMV disease whilst receiving valganciclovir (ValGCV) prophylaxis. Read More

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http://dx.doi.org/10.1002/rmv.2023DOI Listing
March 2019
2 Reads

Etiology of acute viral respiratory infections common in Pakistan: A review.

Rev Med Virol 2019 Mar 12;29(2):e2024. Epub 2018 Dec 12.

Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan.

Respiratory infections, especially those of the lower respiratory tract, remain a foremost cause of mortality and morbidity of children greater than 5 years in developing countries including Pakistan. Ignoring these acute-level infections may lead to complications. Particularly in Pakistan, respiratory infections account for 20% to 30% of all deaths of children. Read More

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http://dx.doi.org/10.1002/rmv.2024DOI Listing
March 2019
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Research advancements in the neurological presentation of flaviviruses.

Rev Med Virol 2019 01 12;29(1):e2021. Epub 2018 Dec 12.

Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.

Owing to the large-scale epidemic of Zika virus disease and its association with microcephaly, properties that allow flaviviruses to cause nervous system diseases are an important area of investigation. At present, although potential pathogenic mechanisms of flaviviruses in the nervous system have been examined, they have not been completely elucidated. In this paper, we review the possible mechanisms of blood-brain barrier penetration, the pathological effects on neurons, and the association between virus mutations and neurotoxicity. Read More

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http://dx.doi.org/10.1002/rmv.2021DOI Listing
January 2019
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Rotavirus infections in children in Turkey: A systematic review.

Rev Med Virol 2019 01 4;29(1):e2020. Epub 2018 Dec 4.

Department of Public Health, Gazi University Faculty of Medicine, Ankara, Turkey.

We aimed to describe rotavirus epidemiology and clinical findings including extraintestinal manifestations in a setting that has yet to introduce rotavirus vaccines in the national immunization program. A literature search was performed by using the key words "Turkey" and "rotavirus." Ninety-eight studies published between 1987 and 2016 including epidemiological, clinical, and genotypical data at least 1 year duration were included. Read More

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http://dx.doi.org/10.1002/rmv.2020DOI Listing
January 2019
4 Reads

DNA methyltransferases in virus-associated cancers.

Rev Med Virol 2019 Mar 3;29(2):e2022. Epub 2018 Dec 3.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Human tumor viruses are either casually linked or contribute in the development of human cancers. Viruses can stimulate oncogenesis through affecting diverse biological pathways in human cells. Growing data have demonstrated frequent involvement of one of the most characteristic parts of cellular epigenetic machinery, DNA methylation, in the oncogenesis. Read More

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http://doi.wiley.com/10.1002/rmv.2022
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March 2019
2 Reads

Virus detection by transmission electron microscopy: Still useful for diagnosis and a plus for biosafety.

Rev Med Virol 2019 01 9;29(1):e2019. Epub 2018 Nov 9.

INSERM U1259, Université de Tours et CHU de Tours, Tours, France.

Transmission electron microscopy (TEM) is the only imaging technique allowing the direct visualization of viruses, due to its nanometer-scale resolution. Between the 1960s and 1990s, TEM contributed to the discovery of many types of viruses and served as a diagnostic tool for identifying viruses directly in biological samples, either in suspension or in sections of tissues or mammalian cells grown in vitro in contact with clinical samples. The diagnosis of viral infections improved considerably during the 1990s, with the advent of highly sensitive techniques, such as enzyme-linked immunosorbent assay (ELISA) and PCR, rendering TEM obsolete for this purpose. Read More

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http://doi.wiley.com/10.1002/rmv.2019
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January 2019
23 Reads

An emerging novel virus: Atypical porcine pestivirus (APPV).

Rev Med Virol 2019 01 9;29(1):e2018. Epub 2018 Nov 9.

College of Veterinary Medicine, Yangzhou University, Yangzhou, China.

Emerging porcine pestivirus diseases frequently challenge prevention and control strategies in the swine industry. Over the past decade, a few novel pestiviruses have been identified in pigs. This article focuses on the recently emerging atypical porcine pestivirus (APPV) that potentially threatens global swine herd health security. Read More

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http://doi.wiley.com/10.1002/rmv.2018
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January 2019
21 Reads

Influenza vaccine: Where are we and where do we go?

Rev Med Virol 2019 01 8;29(1):e2014. Epub 2018 Nov 8.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

The alarming rise of morbidity and mortality caused by influenza pandemics and epidemics has drawn attention worldwide since the last few decades. This life-threatening problem necessitates the development of a safe and effective vaccine to protect against incoming pandemics. The currently available flu vaccines rely on inactivated viral particles, M2e-based vaccine, live attenuated influenza vaccine (LAIV) and virus like particle (VLP). Read More

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http://doi.wiley.com/10.1002/rmv.2014
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January 2019
27 Reads
5.574 Impact Factor

An update on enterovirus 71 infection and interferon type I response.

Rev Med Virol 2019 01 30;29(1):e2016. Epub 2018 Oct 30.

Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Enteroviruses are members of Pichornaviridae family consisting of human enterovirus group A, B, C, and D as well as nonhuman enteroviruses. Hand, foot, and mouth disease (HFMD) is a serious disease which is usually seen in the Asia-Pacific region in children. Enterovirus 71 and coxsackievirus A16 are two important viruses responsible for HFMD which are members of group A enterovirus. Read More

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http://doi.wiley.com/10.1002/rmv.2016
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January 2019
19 Reads

Orf virus: A promising new therapeutic agent.

Rev Med Virol 2019 01 28;29(1):e2013. Epub 2018 Oct 28.

Department of Laboratory Medicine, School of Stomatology and Medicine, Foshan University, Foshan, Guangdong Province, China.

The orf virus (ORFV) is a zoonotic, epitheliotropic, DNA parapoxvirus that infects principally sheep and goats. Exposure of animals to the virus or immunization by an ORFV preparation can accentuate the severity of disease, which has provoked an interest in the underlying cellular, virological, and molecular mechanisms. The identified ORFV virulence genes and the fact that the virus can repeatedly infect a host, owing to its evasive mechanisms, contribute to the development of potent immune modulators in various animal species. Read More

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http://doi.wiley.com/10.1002/rmv.2013
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January 2019
14 Reads
5.574 Impact Factor

Going beyond serology for stratifying the risk of CMV infection in transplant recipients.

Rev Med Virol 2019 01 25;29(1):e2017. Epub 2018 Oct 25.

National Center of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

Knowledge of donor and recipient (D/R) cytomegalovirus (CMV) serostatus is critical for risk stratification of CMV infection and disease in transplant recipients, particularly in the solid organ transplantation (SOT) setting. Despite its broad availability and the success of it use, the risk stratification based on the D/R serostatus is not free of limitations since there are a nondepreciable number of patients that are not accurately categorized by this approach. In fact, up to 20% of seropositive SOT recipients, classically considered at intermediate risk, develop episodes of CMV infection and disease after transplantation. Read More

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http://doi.wiley.com/10.1002/rmv.2017
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January 2019
2 Reads
5.574 Impact Factor

Reply to Simon et al. on "The neurological complications of chikungunya virus: A systematic review".

Rev Med Virol 2018 11 24;28(6):e2012. Epub 2018 Oct 24.

National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK.

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November 2018
2 Reads

Viral disease of the year: Anterior uveitis.

Authors:
Paul D Griffiths

Rev Med Virol 2018 11 24;28(6):e2015. Epub 2018 Oct 24.

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http://doi.wiley.com/10.1002/rmv.2015
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November 2018
16 Reads

Cytomegalovirus infection in day care centres: A systematic review and meta-analysis of prevalence of infection in children.

Rev Med Virol 2019 01 10;29(1):e2011. Epub 2018 Oct 10.

School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

Maternofetal transmission of cytomegalovirus (CMV) is the most common infectious cause of congenital malformation in developed countries. Maternal infection often results from close contact with infected children, and this may occur in day care centres (DCCs). A systematic review of observational studies was conducted to examine the prevalence of CMV infection among children attending DCCs. Read More

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http://doi.wiley.com/10.1002/rmv.2011
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January 2019
4 Reads

Harnessing CRISPR/Cas 9 System for manipulation of DNA virus genome.

Rev Med Virol 2019 01 27;29(1):e2009. Epub 2018 Sep 27.

Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

The recent development of the Clustered Regularly Interspaced Palindromic Repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system, a genome editing system, has many potential applications in virology. The possibility of introducing site specific breaks has provided new possibilities to precisely manipulate viral genomics. Here, we provide diagrams to summarize the steps involved in the process. Read More

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http://doi.wiley.com/10.1002/rmv.2009
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January 2019
11 Reads

Emerging trends of Nipah virus: A review.

Rev Med Virol 2019 01 24;29(1):e2010. Epub 2018 Sep 24.

Centre for Biotechnology, Maharshi Dayanand University, Rohtak, India.

Since emergence of the Nipah virus (NiV) in 1998 from Malaysia, the NiV virus has reappeared on different occasions causing severe infections in human population associated with high rate of mortality. NiV has been placed along with Hendra virus in genus Henipavirus of family Paramyxoviridae. Fruit bats (Genus Pteropus) are known to be natural host and reservoir of NiV. Read More

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January 2019
4 Reads

Defects in interferon pathways as potential biomarkers of sensitivity to oncolytic viruses.

Rev Med Virol 2018 11 13;28(6):e2008. Epub 2018 Sep 13.

Engelhardt Institute of Molecular Biology, Moscow, Russia.

Increased sensitivity of cancer cells to viruses is a prerequisite for the success of oncolytic virotherapy. One of the major causes of such a phenotype is the disruption of innate antiviral defenses associated with dysfunction of type 1 interferons (IFNs) that permits unlimited replication of viruses in cancer cells. Defects in IFN pathways help cancer progression by providing additional advantages to tumor cells. Read More

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http://doi.wiley.com/10.1002/rmv.2008
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November 2018
28 Reads

Immune function of plasmacytoid dendritic cells, natural killer cells, and their crosstalk in HBV infection.

Rev Med Virol 2018 11 2;28(6):e2007. Epub 2018 Sep 2.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Chronic hepatitis B virus infection is a major health problem, with over 245 million chronic carriers worldwide. This persistent infection is thought to be associated with inefficient innate and adaptive immune responses. Natural killer cells (NK cells) and plasmacytoid dendritic cells (pDCs) are the major innate immune cells which respond to viral infection at the early phase and are considered major components of the antiviral immune response. Read More

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November 2018
25 Reads

Rotavirus: Genetics, pathogenesis and vaccine advances.

Rev Med Virol 2018 11 29;28(6):e2003. Epub 2018 Aug 29.

Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.

Since its discovery 40 years ago, rotavirus (RV) is considered to be a major cause of infant and childhood morbidity and mortality particularly in developing countries. Nearly every child in the world under 5 years of age is at the risk of RV infection. It is estimated that 90% of RV-associated mortalities occur in developing countries of Africa and Asia. Read More

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http://doi.wiley.com/10.1002/rmv.2003
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November 2018
17 Reads

Simplified approach to uncertainty of measurement in the clinical virology laboratory.

Rev Med Virol 2018 11 15;28(6):e2006. Epub 2018 Aug 15.

National Health Laboratory Service, Polokwane, Department of Medical Microbiology, South Africa and Department of Pathology, Division of Medical Microbiology, University of Limpopo, Polokwane, South Africa.

Medical laboratories are required to ensure the quality of their diagnostic results. Quality assurance procedures include quality assessments (internal and external), quality controls (negative, positive, or internal controls), equipment monitoring, and audits. Quality control data may be used to evaluate the uncertainty of measurement. Read More

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November 2018
4 Reads

Dengue hemophagocytic syndrome: A systematic review and meta-analysis on epidemiology, clinical signs, outcomes, and risk factors.

Rev Med Virol 2018 11 15;28(6):e2005. Epub 2018 Aug 15.

Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

We systematically searched and meta-analyzed the epidemiological characteristics, frequency of clinical signs, and outcomes of dengue-associated hemophagocytic lymphohistiocytosis. Ten electronic databases were searched systematically plus manual search of reference lists to identify relevant articles published until May 2017. The highest number of reported cases were from South-East Asia region (62 cases), followed by Western Pacific region (20 cases), and America (31 cases). Read More

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http://dx.doi.org/10.1002/rmv.2005DOI Listing
November 2018
12 Reads
5.574 Impact Factor

Systematic review of the impact of point-of-care testing for influenza on the outcomes of patients with acute respiratory tract infection.

Rev Med Virol 2018 09 13;28(5):e1995. Epub 2018 Aug 13.

Virology Research Laboratory, Prince of Wales Hospital, University of New South Wales, Sydney, NSW, Australia.

Acute respiratory tract infections are a major cause of morbidity and mortality and represent a significant burden on the health care system. Laboratory testing is required to definitively distinguish infecting influenza virus from other pathogens, resulting in prolonged emergency department (ED) visits and unnecessary antibiotic use. Recently available rapid point-of-care tests (POCT) may allow for appropriate use of antiviral and antibiotic treatments and decrease patient lengths of stay. Read More

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http://dx.doi.org/10.1002/rmv.1995DOI Listing
September 2018
14 Reads

"Therapeutic applications of the 'NPGP' family of viral 2As".

Rev Med Virol 2018 11 9;28(6):e2001. Epub 2018 Aug 9.

Centre for Biomolecular Sciences, School of Biology, University of St Andrews, St Andrews, UK.

Oligopeptide "2A" and "2A-like" sequences ("2As"; 18-25aa) are found in a range of RNA virus genomes controlling protein biogenesis through "recoding" of the host-cell translational apparatus. Insertion of multiple 2As within a single open reading frame (ORF) produces multiple proteins; hence, 2As have been used in a very wide range of biotechnological and biomedical applications. During translation, these 2A peptide sequences mediate a eukaryote-specific, self-"cleaving" event, termed "ribosome skipping" with very high efficiency. Read More

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http://dx.doi.org/10.1002/rmv.2001DOI Listing
November 2018
2 Reads

Zooepidemic: Thinking about the HIV pandemic, 40 years on.

Rev Med Virol 2018 09 7;28(5):e2004. Epub 2018 Aug 7.

formerly of Central Public Health Laboratory.

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http://dx.doi.org/10.1002/rmv.2004DOI Listing
September 2018
2 Reads

The wide spectrum of neurological consequences of chikungunya disease.

Rev Med Virol 2018 11 3;28(6):e1999. Epub 2018 Aug 3.

Department of Neurology, CHU Guadeloupe, Les Abymes, Guadeloupe, France.

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http://dx.doi.org/10.1002/rmv.1999DOI Listing
November 2018
3 Reads

Untold stories of the Zika virus epidemic in Brazil.

Rev Med Virol 2018 11 3;28(6):e2000. Epub 2018 Aug 3.

Department of Infectious and Parasitic Diseases, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.

The Zika virus infection outbreak in Brazil in 2014 to 2015 resulted in the identification of previously unknown consequences of the disease, including the notorious microcephaly among many defects in fetuses born to women infected during pregnancy. A number of individuals were involved in this remarkable discovery, from the detection of viral circulation in the country to the studies on the causal link with congenital abnormalities and the provision of awareness and social support to families affected by the disease. In this article, we review the background to this experience, describing aspects of the epidemiology, medical research, and scientific response to the Zika virus outbreak in Brazil. Read More

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http://dx.doi.org/10.1002/rmv.2000DOI Listing
November 2018
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Molecular epidemiology and phylogenetics of human enteroviruses: Is there a forest behind the trees?

Rev Med Virol 2018 11 1;28(6):e2002. Epub 2018 Aug 1.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany.

Enteroviruses are among the best studied small non-enveloped enteric RNA viruses. Most enteroviruses are easy to isolate in cell culture, and many non-polio enterovirus strains were archived worldwide as a byproduct of the WHO poliovirus surveillance system. Common outbreaks and epidemics, most prominently the epidemic of hand-foot-and-mouth disease with severe neurological complications in East and South-East Asia, justify practical interest of non-polio enteroviruses. Read More

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http://dx.doi.org/10.1002/rmv.2002DOI Listing
November 2018
14 Reads

Can we distinguish respiratory viral infections based on clinical features? A prospective pediatric cohort compared to systematic literature review.

Rev Med Virol 2018 09 24;28(5):e1997. Epub 2018 Jul 24.

Vienna Vaccine Safety Initiative, Berlin, Germany.

Studies have shown that the predictive value of "clinical diagnoses" of influenza and other respiratory viral infections is low, especially in children. In routine care, pediatricians often resort to clinical diagnoses, even in the absence of robust evidence-based criteria. We used a dual approach to identify clinical characteristics that may help to differentiate infections with common pathogens including influenza, respiratory syncytial virus, adenovirus, metapneumovirus, rhinovirus, bocavirus-1, coronaviruses, or parainfluenza virus: (a) systematic review and meta-analysis of 47 clinical studies published in Medline (June 1996 to March 2017, PROSPERO registration number: CRD42017059557) comprising 49 858 individuals and (b) data-driven analysis of an inception cohort of 6073 children with ILI (aged 0-18 years, 56% male, December 2009 to March 2015) examined at the point of care in addition to blinded PCR testing. Read More

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http://dx.doi.org/10.1002/rmv.1997DOI Listing
September 2018
4 Reads

Developmental progress of CRISPR/Cas9 and its therapeutic applications for HIV-1 infection.

Rev Med Virol 2018 09 19;28(5):e1998. Epub 2018 Jul 19.

Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.

The CRISPR/Cas9 system has been developed as a powerful tool for targeted gene editing. As a result of technical enhancements in recent years, this technology has become the method of choice for efficiently modifying targeted HIV-1 genome efficiently as part of HIV therapy. CRISPR can be modified to target specific sequences that Cas9 then cuts. Read More

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http://dx.doi.org/10.1002/rmv.1998DOI Listing
September 2018
11 Reads

Contribution of herpesviruses in the progression of periodontal and peri-implant diseases in systemically healthy individuals.

Rev Med Virol 2018 09 19;28(5):e1996. Epub 2018 Jul 19.

Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA.

The aim of this review was to assess the contribution of herpesviruses in the subgingival oral biofilm in the progression of periodontal and peri-implant diseases in systemically healthy individuals. The literature review was customized to summarize the pertinent information for the following reasons: (1) A systematic review regarding the role of herpesviruses in the etiopathogenesis of periodontal disease has recently been published; and (2) a limited number of studies have assessed the association of herpesviruses with peri-implant diseases. To date, five observational studies have assessed the presence of herpesviruses in the subgingival oral biofilm of individuals with peri-implant diseases. Read More

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http://doi.wiley.com/10.1002/rmv.1996
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http://dx.doi.org/10.1002/rmv.1996DOI Listing
September 2018
13 Reads
5.574 Impact Factor

Deregulation of the Notch pathway as a common road in viral carcinogenesis.

Rev Med Virol 2018 09 28;28(5):e1988. Epub 2018 Jun 28.

Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

The Notch pathway is a conserved signaling pathway and a form of direct cell-cell communication related to many biological processes during development and adulthood. Deregulation of the Notch pathway is involved in many diseases, including cancer. Almost 20% of all cancer cases have an infectious etiology, with viruses responsible for at least 1. Read More

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http://dx.doi.org/10.1002/rmv.1988DOI Listing
September 2018
2 Reads