6,700 results match your criteria Review of Cornea & Contact Lenses [Journal]


Medical and surgical management of conjunctivochalasis.

Ocul Surf 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address:

Conjunctivochalasis (CCH) is a bilateral conjunctival condition characterized by loose, redundant conjunctival folds, typically in the inferior bulbar conjunctiva. It is a common cause of ocular irritation, especially in older age. For asymptomatic CCH, no treatment is necessary. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15420124183045
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http://dx.doi.org/10.1016/j.jtos.2019.04.008DOI Listing
April 2019
6 Reads

[Panorama of limbal alterations].

J Fr Ophtalmol 2019 Apr 17. Epub 2019 Apr 17.

Service d'ophtalmologie, hôpital Charles Nicolle, Rouen university hospital, CHU de Rouen, 1, rue de Germont, 76000 Rouen, France.

The corneal limbus is a privileged region on the border between two quite different microenvironments, where corneal epithelial stem cells, numerous melanocytes, and antigen-presenting cells are all concentrated within a richly vascularized and innervated stroma. This situation within the ocular surface confers on it the key functions of barrier, epithelial renewal and defense of the cornea. As an immunological crossroads and since the corneoscleral limbus is directly exposed to external insults such as caustic agents, ultraviolet radiation, microbial agents, and allergens, it is the potential site of many tumoral, degenerative or inflammatory pathologies and may progress under certain conditions to limbal stem cell deficiency. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.08.016DOI Listing

Regulation of Matrix Metalloproteinase 2 and 9 in Corneal Neovascularization.

Chem Biol Drug Des 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, 2nd Hospital of Jilin University, Changchun, 130041, China.

Corneal neovascularization (CNV), a pathological process of angiogenesis, can lead to serious consequences in the cornea. CNV is generally proved to associate with inflammation in the cornea closely, which is mainly elicited by the disruption of equilibrium between angiogenic and anti-angiogenic factors. Angiogenic factors including vascular endothelial growth factors (VEGFs), basic fibroblast growth factors (bFGFs) and matrix metalloproteinases (MMPs) are vital factors in the formation of CNV. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13529
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http://dx.doi.org/10.1111/cbdd.13529DOI Listing
April 2019
1 Read

Corneal Tomography Changes and Refractive Outcomes After Descemet Stripping Without Endothelial Keratoplasty.

Cornea 2019 Apr 16. Epub 2019 Apr 16.

Cornea and Refractive Surgery Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.

Purpose: To investigate corneal tomography changes and refractive outcomes after Descemetorhexis without endothelial keratoplasty (DWEK).

Methods: Retrospective chart review of 25 eyes from 16 patients with Fuchs corneal endothelial dystrophy that underwent successful DWEK combined with cataract surgery.

Results: There was no significant change in anterior corneal curvature on tomography maps. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001896DOI Listing

Implementations of 3D printing in ophthalmology.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 16. Epub 2019 Apr 16.

Department of Ophthalmology, Rambam Health Care Campus, 9602, 31096, Haifa, Israel.

Purpose: The purpose of this paper is to provide an in-depth understanding of how to best utilize 3D printing in medicine, and more particularly in ophthalmology in order to enhance the clinicians' ability to provide out-of-the-box solutions for unusual challenges that require patient personalization. In this review, we discuss the main applications of 3D printing for diseases of the anterior and posterior segments of the eye and discuss their current status and implementation. We aim to raise awareness among ophthalmologists and report current and future developments. Read More

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http://link.springer.com/10.1007/s00417-019-04312-3
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http://dx.doi.org/10.1007/s00417-019-04312-3DOI Listing
April 2019
1 Read

Step-by-step Descemet's membrane endothelial keratoplasty surgery.

Taiwan J Ophthalmol 2019 Jan-Mar;9(1):18-26

Cornea Services, Devers Eye Institute, Portland, OR, USA.

With the success of Descemet's stripping automated endothelial keratoplasty (DSAEK) technique providing better outcomes in visual prognosis and theoretically lower rejection rate than penetrating keratoplasty, DSAEK dominated the realm of endothelial keratoplasty for the past decade. However, Descemet's membrane endothelial keratoplasty (DMEK) has become more and more popular worldwide due to its even lower rejection rate, faster visual recovery, better visual outcome, and lower long-term endothelial loss. In this article, we demonstrate the techniques and nuances of DMEK surgery in detail for corneal specialists who are beginning their DMEK surgeries. Read More

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http://dx.doi.org/10.4103/tjo.tjo_108_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432849PMC
April 2019
2 Reads

Clinical Outcomes of Lifitegrast 5% Ophthalmic Solution in the Treatment of Dry Eye Disease.

Eye Contact Lens 2019 Apr 10. Epub 2019 Apr 10.

Division of Cornea and External Disease, Kellogg Eye Center (A.Y.T.), University of Michigan, Ann Arbor, MI; Department of Ophthalmology (S.F.P.), Duke University Eye Center, Durham, NC; and Division of Cornea and Refractive Surgery (P.K.G.), Department of Ophthalmology, Duke University Eye Center, Durham, NC.

Purpose: To evaluate the clinical characteristics, outcomes, and adverse reactions after the use of lifitegrast 5% ophthalmic solution for the treatment of patients with dry eye disease (DED).

Methods: Retrospective chart review was performed in 121 patients seen at the Duke Eye Center with DED who were prescribed lifitegrast 5% and seen for follow-up after treatment initiation. Charts were reviewed for meibomian gland dysfunction (MGD) grading, conjunctival and corneal staining scores, and tear breakup time (TBUT), as well as matrix metalloproteinase-9 (MMP-9) levels. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000601DOI Listing
April 2019
1 Read

Mesenchymal Stromal Cells for Ocular Surface Repair.

Expert Opin Biol Ther 2019 Apr 12. Epub 2019 Apr 12.

a Student. Institute of Genetic Medicine, Newcastle University, International Centre for Life , Newcastle upon Tyne , UK.

Introduction: Cornea is a transparent, robust tissue that comprises highly organized cells. Disruption of this specialized tissue, can lead to scarring and subsequent blindness, making corneal damage a considerable challenge worldwide. At present, the available medical treatments are unable to address the wide range of corneal diseases. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2019.1
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http://dx.doi.org/10.1080/14712598.2019.1607836DOI Listing
April 2019
4 Reads

Tectonic keratoplasty using femtosecond laser lenticule in pediatric patients with corneal perforation secondary to blepharokeratoconjunctivitis: a case report and literature review.

J Int Med Res 2019 Apr 11:300060519841163. Epub 2019 Apr 11.

1 Department of Ophthalmology, the First Hospital of Jilin University, Changchun, Jilin Province, China.

Blepharokeratoconjunctivitis secondary to ocular demodicosis in the pediatric population is often neglected and may result in a serious sight-threatening condition. In severe cases, it can lead to corneal perforation necessitating urgent corneal transplantation. However, the shortage and high cost of donor corneas is the foremost limitation of keratoplasty in developing countries. Read More

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http://dx.doi.org/10.1177/0300060519841163DOI Listing
April 2019
1 Read
1.095 Impact Factor

Sterile keratitis following standard corneal collagen crosslinking: A case series and literature review.

J Fr Ophtalmol 2019 Apr 5. Epub 2019 Apr 5.

Quinze-Vingts national ophthalmology hospital, 28, rue de Charenton, 75012 Paris, France; UMR S 968, Sorbonne université - UPMC université Paris 06, 75012 Paris, France; Institut de la vision, 75012 Paris, France. Electronic address:

Standard corneal collagen crosslinking (S-CXL) is a safe, approved procedure, but it may result in severe pain, early vision loss and possible complications, such as infectious or sterile keratitis, in some cases. We describe four cases of sterile infiltrates after uneventful S-CXL for keratoconus, from diagnosis to medical management with six months of follow-up, reporting their pathophysiological features, and comparing our findings with published reports. We discuss various possibilities for diagnosing sterile infiltration more rapidly. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.11.015DOI Listing

Strategies for Improving Ocular Drug Bioavailability and Corneal Wound Healing with Chitosan-Based Delivery Systems.

Polymers (Basel) 2018 Nov 3;10(11). Epub 2018 Nov 3.

Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", Bucharest 020956, Romania.

The main inconvenience of conventional eye drops is the rapid washout of the drugs due to nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be improved by either prolonging retention time in the cul-de-sac or by increasing the ocular permeability. The focus of this review is to highlight some chitosan-based drug delivery approaches that proved to have good clinical efficacy and high potential for use in ophthalmology. Read More

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http://dx.doi.org/10.3390/polym10111221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290606PMC
November 2018
1 Read

MicroRNAs in the cornea: Role and implications for treatment of corneal neovascularization.

Ocul Surf 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology, Institute for Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linköping, Sweden; Department of Ophthalmology, Sørlandet Hospital Arendal, Arendal, Norway. Electronic address:

With no safe and efficient approved therapy available for treating corneal neovascularization, the search for alternative and effective treatments is of great importance. Since the discovery of miRNAs as key regulators of gene expression, knowledge of their function in the eye has expanded continuously, facilitated by high throughput genomic tools such as microarrays and RNA sequencing. Recently, reports have emerged implicating miRNAs in pathological and developmental angiogenesis. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.04.002DOI Listing
April 2019
1 Read

In vivo confocal microscopy of the inflamed anterior segment: a review of clinical and research applications.

Clin Exp Ophthalmol 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

In vivo confocal microscopy (IVCM) allows non-invasive imaging of the living human cornea, specifically enabling the detection of immune cells in the healthy and diseased ocular anterior segment. Studies using IVCM have provided insight into the effects of contact lens wear on corneal Langerhans cell density and morphology, and the effects of eye drops on conjunctiva-associated lymphoid tissue. IVCM has also been shown to be a useful adjunctive diagnostic tool in distinguishing infective and non-infective uveitis and in diagnosing atypical infective keratitis. Read More

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http://dx.doi.org/10.1111/ceo.13512DOI Listing

Corneal Edema Associated With Systemic Dopaminergic Agents.

Cornea 2019 Apr 2. Epub 2019 Apr 2.

James A Haley VA Eye Clinic.

Purpose: To describe the development and resolution of corneal edema in 3 patients who were exposed to compounds that stimulate dopaminergic pathways.

Methods: We conducted a review of the literature on bilateral corneal edema secondary to amantadine use and report a case series of corneal edema seen in an outpatient ophthalmology specialty clinic, shortly after exposure to agents that enhance dopamine transmission.

Results: Cases 1 and 2 report a 25-year-old man with attention-deficit hyperactivity disorder and a 73-year-old man with Parkinson disease who were placed on dopaminergic medications to treat their conditions. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001941DOI Listing
April 2019
2 Reads

Phacolytic glaucoma: A nearly forgotten entity.

Eur J Ophthalmol 2019 Apr 5:1120672119841972. Epub 2019 Apr 5.

1 Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose:: To report a case of phacolytic glaucoma with rupture of anterior lens capsule in a case of hypermature cataract.

Methods:: Case report and literature review.

Results:: An 80-year-old woman presented with cloudiness and pain in the left eye for 1 day. Read More

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http://dx.doi.org/10.1177/1120672119841972DOI Listing
April 2019
9 Reads

Protocol for a systematic review, meta-analysis, and trial sequential analysis of clinical outcomes following accelerated versus conventional corneal collagen cross-linking for corneal ectasia.

Syst Rev 2019 Apr 4;8(1):85. Epub 2019 Apr 4.

Health Sciences Library, McMaster University, Hamilton, Ontario, Canada.

Background: Collagen cross-linking (CXL) is an evolving procedure that enhances the biomechanical rigidity of the cornea and can slow or halt ectatic disease. CXL requires delivery of 5.4 J/cm of ultraviolet A (UVA) radiation to a cornea saturated with riboflavin in order to induce cross-link formation. Read More

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http://dx.doi.org/10.1186/s13643-019-1004-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449983PMC
April 2019
4 Reads

Ocular surface system alterations in ocular graft-versus-host disease: all the pieces of the complex puzzle.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 3. Epub 2019 Apr 3.

Ophthalmology Unit, St. Orsola-Malpighi University Hospital, University of Bologna, Via Palagi 9, 40138, Bologna, Italy.

Purpose: Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cells transplantation, occurring in about half of transplanted patients. This condition seems to be the result of a progressive immune-mediated damage that can involve various tissues, including the eyes. The ocular surface system is the ocular structure most frequently impaired, and dry eye disease is considered the hallmark of ocular GVHD. Read More

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http://link.springer.com/10.1007/s00417-019-04301-6
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http://dx.doi.org/10.1007/s00417-019-04301-6DOI Listing
April 2019
3 Reads

Recent Surgical Trends in Pediatric Corneal Transplantation: A 13-Year Review.

Cornea 2019 May;38(5):546-552

Department of Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, MD.

Purpose: Corneal transplantation is the standard of care for pediatric corneal opacities, but little consensus exists on optimal surgical management. Our goal was to evaluate cross-sectional data of donor and recipient characteristics collected from eye banks providing tissue for pediatric corneal transplant cases to assess surgical trends in pediatric keratoplasty over the past 13 years.

Methods: We performed a retrospective review of recipient data, collected from 4 major eye banks, for pediatric patients (<18 years) who underwent corneal transplantation between January 2005 and December 2017. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001900DOI Listing
May 2019
2 Reads

Advances in Corneal Imaging: Current Applications and Beyond.

Asia Pac J Ophthalmol (Phila) 2019 Apr 1. Epub 2019 Apr 1.

Department of Ophthalmology, The University of Hong Kong, Hong Kong.

Recent advances in corneal imaging have allowed for more objective diagnosis and disease monitoring, as well as provided valuable guidance for treatment progress. However, there has been limited literature providing comprehensive insight into advances across different imaging modalities. The aim of this review was to provide a brief summary of significant advances in the field of corneal imaging over the past 5 years. Read More

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http://dx.doi.org/10.22608/APO.2018537DOI Listing
April 2019
1 Read

Methylprednisolone Acetate (Depo-MedrolTM) Injection During Cataract Surgery Causing Retinal Necrosis.

Ophthalmology 2019 Mar 28. Epub 2019 Mar 28.

Retina Consultants of Michigan, Southfield, MI.

Purpose: To report a case of retinal necrosis after Depo-Medrol injection during complicated cataract surgery.

Methods: Interventional case report. A PubMed search was conducted using the search terms "methylprednisolone acetate" and "intraocular" as well as "methylprednisolone acetate" and "cataract surgery. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.03.034DOI Listing
March 2019
1 Read

Matrix metalloproteinases in keratoconus - Too much of a good thing?

Exp Eye Res 2019 Mar 23;182:137-143. Epub 2019 Mar 23.

Section of Ophthalmology and Neuroscience, Leeds Institute of Medical Research, University of Leeds, Wellcome Trust Brenner Building, Beckett Street, Leeds, LS9 7TF, United Kingdom. Electronic address:

Keratoconus (KC) is a progressive, early onset, and often bilateral eye condition, in which the cornea gradually weakens and bulges out, and in advanced cases may eventually become cone-shaped. The available evidence suggests that it is a multifactorial disease with environmental and genetic contributions. Matrix Metalloproteinases (MMPs) are a family of 24 zinc-dependent proteases with the ability to degrade collagen and other extracellular matrix (ECM) proteins, which are important components of the cornea. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183079
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http://dx.doi.org/10.1016/j.exer.2019.03.016DOI Listing
March 2019
2 Reads

Utility of nanomedicine targeting scar-forming myofibroblasts to attenuate corneal scarring and haze.

Nanomedicine (Lond) 2019 Apr 22;14(8):1049-1072. Epub 2019 Mar 22.

Nanomedicine-Laboratory of Immunology & Molecular Biomedical Research (NLIMBR), School of Medicine (SOM), Faculty of Health, Deakin University, Waurn Ponds, Geelong 3216, Australia.

Corneal scarring refers to the loss of normal corneal tissue, replaced by fibrotic tissue (during wound repair) thereby affecting corneal transparency and vision quality. The corneal wound healing process involves a complex series of physiological events resulting in the transformation of transparent keratocytes into opaque myofibroblasts; the prominent cause of irregular extracellular matrix synthesis leading to the development of corneal opacity/hazy vision. Globally, corneal scarring/haze is one of the most prevalent causes of blindness. Read More

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http://dx.doi.org/10.2217/nnm-2017-0305DOI Listing

Corneal wasp sting: A case report and review of literature.

J Curr Ophthalmol 2019 Mar 10;31(1):95-97. Epub 2018 Apr 10.

Department of Ophthalmology, Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To report severe immunologic and toxic reaction due to corneal wasp sting that may cause catastrophic sight-threatening outcomes.

Methods: A 45-year-old man referred to the emergency room with corneal wasp sting of Vespa Orientalis. The authors review previous Medline literature about this topic. Read More

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http://dx.doi.org/10.1016/j.joco.2018.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407084PMC

Acanthamoeba keratitis - Clinical signs, differential diagnosis and treatment.

J Curr Ophthalmol 2019 Mar 19;31(1):16-23. Epub 2018 Oct 19.

Department of Ophthalmology, Saarland University Medical Center, UKS, Homburg, Saar, Germany.

Purpose: To summarize actual literature data on clinical signs, differential diagnosis, and treatment of acanthamoeba keratitis.

Methods: Review of literature.

Results: Clinical signs of acanthamoeba keratitis are in early stages grey-dirty epithelium, pseudodendritiformic epitheliopathy, perineuritis, multifocal stromal infiltrates, ring infiltrate and in later stages scleritis, iris atrophy, anterior synechiae, secondary glaucoma, mature cataract, and chorioretinitis. Read More

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http://dx.doi.org/10.1016/j.joco.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407156PMC
March 2019
2 Reads

Retinal structural-vascular-functional relationship using optical coherence tomography and optical coherence tomography - angiography in myopia.

Eye Vis (Lond) 2019 7;6. Epub 2019 Mar 7.

1Department of Retina and Vitreous, Narayana Nethralaya, #121/C, 1st R Block, Chord RoadRajaji Nagar, Bengaluru, 560010 India.

Background: To examine the retinal structure-vascular-function relationship using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in myopia.

Methods: This was a prospective cross-sectional study comprising 86 eyes of 45 individuals with varying axial lengths and spherical equivalents and no posterior segment abnormalities. All eyes underwent optical coherence tomography with the Spectralis SD-OCT and OCTA with RTVue-XR Avanti; Optovue. Read More

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http://dx.doi.org/10.1186/s40662-019-0133-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404328PMC
March 2019
3 Reads

Severe mycotic keratoconjunctivitis caused by sp. in an immunocompetent child successfully treated with intravenous voriconazole and keratoplasty: case report and short review of the literature.

Ther Adv Infect Dis 2019 Jan-Dec;6:2049936118811213. Epub 2018 Nov 12.

University of Texas Rio Grande Valley, Rio Grande Valley, TX, USA.

Background: Pediatric mycotic infections in the eye are uncommon. However, ophthalmic infections by several fungal species have been described in immunocompetent subjects. Mycotic keratitis with or without conjunctivitis (MK) may account for more than 50% of all cases, particularly in tropical and sub-tropical areas. Read More

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http://dx.doi.org/10.1177/2049936118811213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416680PMC
November 2018

Topical application of polymeric nanomicelles in ophthalmology: a review on research efforts for the noninvasive delivery of ocular therapeutics.

Expert Opin Drug Deliv 2019 Mar 20:1-17. Epub 2019 Mar 20.

a Department of Food and Drug , University of Parma , Parma , Italy.

Introduction: Polymeric micelles represent nowadays an interesting formulative approach for ocular drug delivery, as they act as solubility enhancers of poorly soluble drugs and promote drug transport across cornea and sclera. In particular, in the last 5 years polymeric nanomicelles have been increasingly investigated to overcome some of the important challenges of the topical treatment of ocular diseases. Areas covered: The aim of this review was to gather up-to-date information on the different roles that polymeric micelles (commonly in the nanosize scale) can play in ocular delivery. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2019.1
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http://dx.doi.org/10.1080/17425247.2019.1597848DOI Listing
March 2019
7 Reads

Equine ulcerative keratitis with furrow: A review of the outcomes of 72 cases from 1987 to 2015.

Equine Vet J 2019 Mar 18. Epub 2019 Mar 18.

Comparative Ophthalmology, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.

Background: Ulcerative keratitis with peripheral furrow formation is a poorly-described condition which has been associated with a grave prognosis due to rapid necrosis of the cornea.

Objective: To describe the infectious aetiologies associated with furrow-forming ulcerative keratitis, its overall clinical course and the efficacy of medical and surgical intervention in horses.

Study Design: Retrospective clinical case series. Read More

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http://dx.doi.org/10.1111/evj.13101DOI Listing

Corneal Cross-Linking: The Science Beyond the Myths and Misconceptions.

Cornea 2019 Mar 12. Epub 2019 Mar 12.

Department of Pharmacy, University Federico II of Naples, Naples, Italy.

Purpose: There has been a recent explosion in the variety of techniques used to accomplish corneal cross-linking (CXL) for the treatment of ectatic corneal diseases. To understand the success or failure of various techniques, we review the physicochemical basis of corneal CXL and re-evaluate the current principles and long-standing conventional wisdom in the light of recent, compelling, and sometimes contradictory research.

Methods: Two clinicians and a medicinal chemist developed a list of current key topics, controversies, and questions in the field of corneal CXL based on information from current literature, medical conferences, and discussions with international practitioners of CXL. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9657
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http://dx.doi.org/10.1097/ICO.0000000000001912DOI Listing
March 2019
5 Reads

Iatrogenic Damage of Eye Tissues: Current Problems and Possible Solutions.

Biochemistry (Mosc) 2018 Dec;83(12):1563-1574

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.

Visual system is at high risk of iatrogenic damage. Laser ocular surgery, the use of powerful illumination devices in diagnostics and surgical treatment of eye diseases, as well as long surgeries under general anesthesia provoke the development of chronic degenerative changes in eye tissues, primarily in the cornea and the retina. Despite the existence of approaches for prevention and treatment of these complications, the efficacy of these approaches is often limited. Read More

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http://dx.doi.org/10.1134/S0006297918120143DOI Listing
December 2018
1 Read

Impact of human leukocyte antigen and calculated panel reactive antibody on BK viremia in kidney transplant recipients: A single-center experience and literature review.

Transpl Infect Dis 2019 Mar 13:e13071. Epub 2019 Mar 13.

Division of Nephrology and Transplant Program, University of Kentucky, Lexington, KY, United States.

Background: The aim of this retrospective analysis was to investigate the effect of human leukocyte antigen (HLA) and calculated panel reactive antibody (cPRA) on BK virus activation as evidenced by BK viremia (BKV).

Patients And Methods: At our institution, 649 kidney transplant patients were screened for BKV from 2009 to 2017. Patients were considered to have BKV if they had greater than 10,000 copies/ml of BK DNA in their blood. Read More

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http://dx.doi.org/10.1111/tid.13071DOI Listing

A Critical Overview of the Biological Effects of Mitomycin C Application on the Cornea Following Refractive Surgery.

Adv Ther 2019 Apr 11;36(4):786-797. Epub 2019 Mar 11.

Clínica Novovisión, Madrid, Spain.

During the last 2 decades, modifying the shape of the cornea by means of laser photoablation has emerged as a successful and popular treatment option for refractive errors. Corneal surface ablation techniques such as photorefractive keratectomy (PRK) and laser-assisted subepithelial keratomileusis (LASEK) offer good refractive results while having a minimal impact on corneal biomechanical stability. Past limitations of these techniques included the long-term regression of refractive outcome and a vigorous healing response that reduced corneal clarity in some patients (giving rise to what is clinically described as "haze"). Read More

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http://dx.doi.org/10.1007/s12325-019-00905-wDOI Listing

[Presbyopia and refractive surgery].

Authors:
C Albou-Ganem

J Fr Ophtalmol 2019 Mar 8. Epub 2019 Mar 8.

Appartenance clinique de la vision, 230, rue du Fg St Honoré, 75008 Paris, France. Electronic address:

Presbyopia is the progressive loss of accommodation. Accommodation is a quick, precise and involuntary action which enables the eye to change the power of the young crystalline lens to see clearly at all distances. Presbyopia is and age-linked physiologic phenomenon: it results from aging of the lens, which loses its elasticity, gradually becomes rigid and loses the ability to accommodate. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.08.009DOI Listing
March 2019
3 Reads

[Boston keratoprosthesis type 1].

J Fr Ophtalmol 2019 Mar 8;42(3):295-302. Epub 2019 Mar 8.

Centre hospitalier de l'université de Montréal, département d'ophtalmologie, 1000 St-Denis, Montréal, Québec, H2X 0C1 Canada; Fellow en cornée et maladies du segment antérieur de l'université de Montréal, 1000 St-Denis, Montréal, Québec, H2X 0C1 Canada. Electronic address:

Penetrating keratoplasty is the most commonly performed tissue transplant in the world. However, its success depends on the health of the ocular surface and the intact immune privilege of the eye. In the absence of these two conditions, corneal transplants have an increased failure rate and result in corneal blindness. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.08.010DOI Listing
March 2019
6 Reads

Bacteroides Spp. Blebitis, Keratitis, and Endophthalmitis Following Uncomplicated Trabeculectomy.

J Glaucoma 2019 Mar 6. Epub 2019 Mar 6.

University of Alabama at Birmingham Callahan Eye Hospital, Birmingham, USA.

Purpose: To describe the first known case of Bacteroides spp. related blebitis, keratitis, and endophthalmitis following uncomplicated trabeculectomy METHODS:: Case report and literature review CASE: A: 63-year-old immunocompetent white male underwent uncomplicated trabeculectomy of his right eye. Two weeks later, a blebitis with adjacent keratitis was diagnosed, progressing over several days to endophthalmitis despite hourly topical fortified antibiotic therapy. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001235DOI Listing

Late-onset diffuse lamellar keratitis following laser in situ keratomileusis.

Can J Ophthalmol 2019 Feb 30;54(1):125-129. Epub 2018 Mar 30.

Department of Ophthalmology, Beaumont Health System, Oakland University William Beaumont School of Medicine, Royal Oak, MI.; Michigan Cornea Consultants, Southfield, MI. Electronic address:

Objective: To analyze 12 cases of late-onset diffuse lamellar keratitis (DLK) following uncomplicated LASIK and propose a method of management.

Design: Retrospective observational case series, literature review.

Participants: Patients who developed late-onset DLK following LASIK. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00084182173072
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http://dx.doi.org/10.1016/j.jcjo.2018.02.028DOI Listing
February 2019
9 Reads

Corneal keloid presenting forty years after penetrating injury: case report and literature review.

Surv Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

A 64-year-old Caucasian man had been diagnosed with presumed ocular surface squamous neoplasia in the left eye and started on topical interferon alpha 2b drops. When we saw him, he provided a history of penetrating corneal injury more than forty years prior. Slit lamp examination revealed a large, elevated, opaque lesion involving the left cornea. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396257183019
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http://dx.doi.org/10.1016/j.survophthal.2019.02.010DOI Listing
March 2019
12 Reads

Combined intrastromal injection of ganciclovir and depot betamethasone for the management of nummular keratitis: Case series.

Arch Soc Esp Oftalmol 2019 Mar 4. Epub 2019 Mar 4.

Sociedad de Oftalmología Eduardo Arenas Archila, Bogotá, Colombia; Universidad Nacional de Colombia, Bogotá, Colombia. Electronic address:

Nummular keratitis is an inflammatory process of the cornea that is characterised by multiple sub-epithelial deposits, for which a variety of therapeutic approaches have been proposed. A retrospective review was performed using the medical records of patients diagnosed with nummular keratitis and treated with a combined intrastromal injection of ganciclovir and depot betamethasone between the years 2009 and 2017. A total of 21 eyes of 16 patients were finally included. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.01.009DOI Listing

Efficacy of Vectored Thermal Pulsation and Warm Compress Treatments in Meibomian Gland Dysfunction: A Meta-Analysis of Randomized Controlled Trials.

Cornea 2019 Mar 4. Epub 2019 Mar 4.

Center for Evidence-Based Health Care and Shared Decision Making Resource Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Purpose: Meibomian gland dysfunction is the main cause of dry eye disease (DED) and is traditionally managed using warm compress treatment (WCT). Vectored thermal pulsation treatment (VTPT) is a novel method for treating DED.

Methods: We conducted a systematic review and meta-analysis of randomized controlled trials that compared the efficacy of VTPT and WCT in treating DED. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001907DOI Listing

Corneal confocal microscopy: ready for prime time.

Clin Exp Optom 2019 Mar 4. Epub 2019 Mar 4.

Division of Research, Qatar Foundation, Weill Cornell Medicine-Qatar, Doha, Qatar.

Corneal confocal microscopy is a non-invasive ophthalmic imaging modality, which was initially used for the diagnosis and management of corneal diseases. However, over the last 20 years it has come to the forefront as a rapid, non-invasive, reiterative, cost-effective imaging biomarker for neurodegeneration. The human cornea is endowed with the densest network of sensory unmyelinated axons, anywhere in the body. Read More

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http://dx.doi.org/10.1111/cxo.12887DOI Listing
March 2019
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1.256 Impact Factor

Panorama of limbal changes.

J Fr Ophtalmol 2019 Mar 2;42(3):e83-e94. Epub 2019 Mar 2.

Ophthalmology service, hôpital Charles-Nicolle, Rouen University hospital, 1, rue de Germont, 76000 Rouen, France.

The corneal limbus is a privileged region on the border between two quite different microenvironments, where corneal epithelial stem cells, numerous melanocytes, and antigen-presenting cells are all concentrated within a richly vascularized and innervated stroma. This situation within the ocular surface confers on it the key functions of barrier, epithelial renewal and defense of the cornea. As an immunological crossroads and since the corneoscleral limbus is directly exposed to external insults such as caustic agents, ultraviolet radiation, microbial agents, and allergens, it is the potential site of many tumoral, degenerative or inflammatory pathologies and may progress under certain conditions to limbal stem cell deficiency. Read More

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http://dx.doi.org/10.1016/j.jfo.2019.02.001DOI Listing
March 2019
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[Prognostic value of changes in the cornea and conjunctiva in diabetes mellitus].

Vestn Oftalmol 2019;135(1):90-97

Ufa Eye Research Institute, 90 Pushkina St., Ufa, Republic of Bashkortostan, Russian Federation, 450008.

Diabetes mellitus (DM) is the most common endocrine disease, and therefore a pressing medical and social problem. In many cases, ocular manifestations of DM are considered the particular cause of patients' disability. The review presents an analysis of morphological, experimental and clinical studies of the cornea in patients with diabetes mellitus - full articles, reviews and monographs of Russian and foreign authors, mostly those published in the recent years. Read More

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http://dx.doi.org/10.17116/oftalma201913501190DOI Listing
January 2019
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Performance and predictability of a new large diameter contact lens design in keratoconic corneae.

Cont Lens Anterior Eye 2019 Feb 26. Epub 2019 Feb 26.

Centro Fernández-Velazquez, C./Matilde Landa, 16, Madrid, Spain. Electronic address:

Objectives: To evaluate the clinical performance and predictability using corneal topography in the fitting of a new large-diameter rigid gas permeable (RGP) contact lens design in eyes with keratoconus (KCN).

Methods: This study presents a review of eyes fitted with Alexa ES lenses for nonsurgical optimisation of visual correction. Anterior steep simulated keratometry (sim-K steep), corneal diameter (HVID), the Curvature at the apex in diopters (Cc), and distance from the corneal apex to the centre of the cornea (Lc) in millimetres derived from the Cone Location and Magnitude Index (CLMI) were recorded. Read More

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http://dx.doi.org/10.1016/j.clae.2019.02.014DOI Listing
February 2019
5 Reads

Management Strategies of Ocular Abnormalities in Patients with Marfan Syndrome: Current Perspective.

J Ophthalmic Vis Res 2019 Jan-Mar;14(1):71-77

Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, USA.

Marfan syndrome is an autosomal dominant genetic connective tissue disorder that results from mutations in the fibrillin-1 gene located on chromosome band 15q15-21. Fibrillin, a glycoprotein, is widely expressed throughout the body and contributes to the elasticity and force-bearing capacity of connective tissue. In the eye, fibrillin is a key constituent of the ciliary zonules, which suspend the crystalline lens in place. Read More

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http://dx.doi.org/10.4103/jovr.jovr_29_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388525PMC
March 2019
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[Search for genetic markers for precise diagnostics of keratoconus].

Biomed Khim 2019 Jan;65(1):9-20

Fyodorov Eye Microsurgery Complex Federal State Institution, Moscow, Russia.

Keratoconus is a chronic disorder of the cornea, characterized by its progressive thinning, stretching, and conical protrusion. Diagnostics of subclinical keratoconus, as well as its early stages (forme fruste), is a complex problem. The presence of these forms of keratoconus in a patient is one of the reasons for the development of keratectasia after laser refractive surgery. Read More

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http://dx.doi.org/10.18097/PBMC20196501009DOI Listing
January 2019

Reducing porcine corneal graft rejection, with an emphasis on porcine endogenous retrovirus transmission safety: a review.

Int J Ophthalmol 2019 18;12(2):324-332. Epub 2019 Feb 18.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China.

Donor cornea shortage is a primary hurdle in the development of corneal transplantation. Of all species, porcine corneas are the ideal transplantation material for humans. However, the xenoimmune rejection induced by porcine corneal xenotransplantation compromises surgical efficacy. Read More

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http://dx.doi.org/10.18240/ijo.2019.02.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376240PMC
February 2019
3 Reads

Trends in contact lens microbial keratitis 1999-2015; a retrospective clinical review.

Clin Exp Ophthalmol 2019 Feb 22. Epub 2019 Feb 22.

School of Optometry and Vision Science, University of New South Wales, Australia.

Importance: Contact lens microbial keratitis (CLMK) is the most common cause of microbial keratitis in our community.

Background: Define the trend in rate of CLMK and define patient demographics/culture results that may have a predictive value in patients with CLMK DESIGN: Retrospective review of clinical records of patients with MK PARTICIPANTS: All patients with positive corneal scraping between 1999-2015 at the Princess Alexandra Hospital, Brisbane, Queensland identified through local microbiology database METHODS: Trend in CLMK tested with chi-squared test of peak 3 years vs other years and Poisson regression of interrupted time series. Patient characteristics predictive of CLMK were defined by creating a polynomial regression model by stepwise variable selection. Read More

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http://dx.doi.org/10.1111/ceo.13484DOI Listing
February 2019
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Indications, Clinical Outcomes, and Survival Rate of Pediatric Penetrating Keratoplasty in Suburban Malaysia: A 10-year Experience.

Cureus 2018 Dec 17;10(12):e3744. Epub 2018 Dec 17.

Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, MYS.

Purpose To describe the demographics, indications, clinical outcomes and survival rate of penetrating keratoplasty in Malaysian children living in a suburban area, and discuss the literature on paediatric penetrating keratoplasty. Methodology A retrospective review of medical records was performed on children younger than 17 years of age who had undergone penetrating keratoplasty in Hospital Universiti Sains Malaysia from January 2008 to December 2017. We recorded demographic data, presenting visual acuity, indications, final visual acuity, and graft survival at 12 months into the postoperative period. Read More

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http://dx.doi.org/10.7759/cureus.3744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384040PMC
December 2018
1 Read