6,633 results match your criteria Review of Cornea & Contact Lenses [Journal]


Recurrent corneal erosion syndrome.

Br J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Ophthalmology, Massachusetts Eye and Ear, Howe Laboratory, Harvard Medical School, Boston, Massachusetts, USA

Recurrent corneal erosion syndrome (RCES) is a disorder characterised by a dysfunctional epithelial ecosystem. It often begins after trauma, or in the setting of epithelial basement membrane degeneration or dystrophy. Historically, RCES has been understood as a structural derangement of the anterior corneal architecture. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-313835DOI Listing
February 2019

Novel dynamic corneal response parameters in a practice use: a critical review.

Biomed Eng Online 2019 Feb 13;18(1):17. Epub 2019 Feb 13.

Department of Biomedical Computer Systems, Faculty of Computer Science and Materials Science, Institute of Computer Science, University of Silesia, ul. Będzińska 39, 41-200, Sosnowiec, Poland.

Background: Non-contact tonometers based on the method using air puff and Scheimpflug's fast camera are one of the latest devices allowing the measurement of intraocular pressure and additional biomechanical parameters of the cornea. Biomechanical features significantly affect changes in intraocular pressure values, as well as their changes, may indicate the possibility of corneal ectasia. This work presents the latest and already known biomechanical parameters available in the new offered software. Read More

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http://dx.doi.org/10.1186/s12938-019-0636-3DOI Listing
February 2019

Algorithmic approach to management of acute ocular chemical injuries-I's and E's of Management.

Ocul Surf 2019 Feb 8. Epub 2019 Feb 8.

CJ Shah Cornea Services/Dr G Sitalakshmi Memorial Clinic for Ocular Surface Disorders, Medical Research Foundation, Sankara Nethralaya, 18 College Road, Chennai, 600006, Tamil Nadu, India.

Ocular chemical injuries are associated with significant morbidity leading to vision loss and ocular surface damage. Appropriate management and intervention in the acute stage dictates the final outcome as well as the prognosis for visual rehabilitative procedures in chronic stage. Classifying the parameters to be addressed in the acute stage and providing an algorithmic approach for managing the alterations in each of them will facilitate the primary goal of ensuring epithelialisation of the ocular surface. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.02.002DOI Listing
February 2019
4 Reads

Xenotransplantation in China: Present status.

Xenotransplantation 2019 Feb 11:e12490. Epub 2019 Feb 11.

Organ Transplant and Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Academy of an Transplant Science & Sichuan Provincial People's Hospital, Chengdu, China.

The main obstacle to organ transplantation is the shortage of organs from deceased individuals. Especially in China, the ratio of patients on the waiting list versus the transplant recipients is 30:1. Therefore, there is an urgent need for organ donors. Read More

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http://dx.doi.org/10.1111/xen.12490DOI Listing
February 2019
1 Read

Long-term outcomes of penetrating keratoplasty for corneal complications of herpes zoster ophthalmicus.

Br J Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

Background/aim: To review the long-term outcomes of penetrating keratoplasty (PKP) for corneal complications of herpes zoster ophthalmicus (HZO).

Methods: We reviewed the medical records of 53 eyes of 53 patients who underwent PKP due to corneal complications of HZO at the Kellogg Eye Center.

Results: The mean age of patients at the time of PKP was 68. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3136
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http://dx.doi.org/10.1136/bjophthalmol-2018-313602DOI Listing
February 2019
3 Reads

Systematic Review on Therapeutic Strategies to Minimize Corneal Stromal Scarring After Injury.

Eye Contact Lens 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology (S.S.K., K.C.S., Y.B., A.C.-Y.L., and J.S.-M.L.), Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China; Department of Ophthalmology (T.C.-Y.C.), Hong Kong Sanatorium and Hospital, Hong Kong, China; Department of Ophthalmology (V.J.), University of Pittsburgh Medical Centre, Pittsburgh, PA; Cornea and External Eye Disease Service (L.T.), Singapore National Eye Centre, Singapore; and Ocular Surface Research Group (L.T.), Singapore Eye Research Institute, Singapore.

Objectives: To evaluate recent studies on available and experimental therapies in preventing or minimizing corneal stromal scarring after injury.

Methods: We performed an Entrez PubMed literature search using keywords "cornea," "scarring," "haze," "opacity," "ulcer," "treatments," "therapies," "treatment complications," and "pathophysiology" resulting in 390 articles of which 12 were analyzed after filtering, based on English language and publication within 8 years, and curation for relevance by the authors.

Results: The 12 articles selected included four randomized control trials (RCTs) (two were double-blinded placebo-controlled RCTs, one was a prospective partially masked RCT, and one was an open-label RCT), two retrospective observational studies, and six laboratory-based studies including two studies having in vivo and in vitro experiments, one was in vivo study, one was ex vivo study, and the last two were in vitro studies. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000584DOI Listing
February 2019
2 Reads

Chronic Conjunctivitis From a Retained Contact Lens.

Eye Contact Lens 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology and Visual Sciences (J.I.A., A.S., and R.R.S.), Case Western Reserve University and University Hospitals Eye Institute, Cleveland, OH; Skyvision Centers (D.E.W.), Westlake, OH; and Division of Cornea and Refractive Surgery (N.A.A.), Shiley Eye Institute, University of California San Diego, San Diego, CA.

Purpose: To help clinicians diagnose and manage unilateral recalcitrant chronic bacterial conjunctivitis secondary to a retained soft contact lens and describe the first report of Gram-negative bacteria causing this condition.

Methods: Chart review of successive cases presenting with unilateral chronic conjunctivitis with positive cultures and a retained contact lens.

Results: Three cases were identified and described. Read More

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http://Insights.ovid.com/crossref?an=00140068-900000000-9917
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http://dx.doi.org/10.1097/ICL.0000000000000587DOI Listing
February 2019
2 Reads

Optical coherence tomography and optical coherence tomography angiography in uveitis: a review.

Clin Exp Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy.

Optical coherence tomography (OCT) has dramatically changed the understanding and management of uveitis and other ocular conditions. Currently, OCT angiography (OCTA) combines structural information with the visualization of blood flow within the imaged area. The aim of this review is to present the basic principles of OCT and OCTA interpretation and to investigate the role of these imaging techniques in the diagnosis and management of uveitis. Read More

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http://dx.doi.org/10.1111/ceo.13470DOI Listing
February 2019

Ophthalmology specialist trainee survey in the United Kingdom.

Eye (Lond) 2019 Feb 1. Epub 2019 Feb 1.

The Royal College of Ophthalmologists, London, UK.

Background: Currently there are a total of 780 post-graduate ophthalmology trainees in the United Kingdom (UK). Post-graduate ophthalmology training in the UK is 7 years in duration, and follows a comprehensive competency-based curriculum. Changes to training have been proposed as part of the government's Shape of Training paper. Read More

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http://dx.doi.org/10.1038/s41433-019-0344-zDOI Listing
February 2019

Clinical and microbiological characteristics of Moraxella keratitis.

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland

Background/aims: To describe the risk factors, clinical features, bacterial subspecies characteristics and treatment outcomes of Moraxella keratitis in a single centre.

Methods: A retrospective review of all patients diagnosed with Moraxella keratitis between November 2012 and December 2017 at the Royal Victoria Eye and Ear Hospital, Dublin, Ireland was performed. Matrix-assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry was used to identify subspecies. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313557DOI Listing
February 2019

[Current and experimental treatment approaches for neurotrophic keratopathy].

Ophthalmologe 2019 Feb;116(2):127-137

Univ.-Klinik für Augenheilkunde, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Neurotrophic Keratopathy: Neurotrophic keratopathy (NK) is a rare corneal disease caused by an impaired corneal innervation. It leads to spontaneous recurrent epithelial defects potentially leading to corneal ulcers and perforation. To avoid severe corneal damage, a prompt and stage-adjusted treatment is necessary. Read More

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http://link.springer.com/10.1007/s00347-018-0843-5
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http://dx.doi.org/10.1007/s00347-018-0843-5DOI Listing
February 2019
3 Reads

Statins in Ophthalmology.

Surv Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

3-Hydroxy-3-methyl-gutaryl coenzyme A (HMG-CoA) reductase inhibitors or 'statins' are a class of lipid lowering drugs with anti-inflammatory, immunomodulatory, and vascular effects. Statins are increasingly being used in the treatment of a variety of medical conditions. We examine the actions of statins on the eye and its associated ophthalmic disorders. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.01.013DOI Listing
January 2019
7 Reads

Polyquaternium-1-Associated Dendritiform Keratopathy.

Cornea 2019 Jan 29. Epub 2019 Jan 29.

Department of Ophthalmology, Baylor College of Medicine, Houston, TX.

Purpose: To report a case of polyquaternium-1 (Polyquad, PQ-1)-associated dendritiform keratopathy that developed after exposure to the tear substitute Systane (Alcon Laboratories, Inc, Fort Worth, TX).

Methods: A retrospective review of the case was performed.

Results: Dendritiform keratopathy developed in the patient after an increase in the use of topical Systane from 4 times per day to every hour. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001885DOI Listing
January 2019

The therapeutic application of mesenchymal stem cells at the ocular surface.

Ocul Surf 2019 Jan 26. Epub 2019 Jan 26.

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, 02114, USA. Electronic address:

The therapeutic potential of mesenchymal stem cells (MSCs) has been heralded by their multipotentiality and immunomodulatory capacity. MSCs migrate toward sites of tissue damage, where specific pro-inflammatory factors 'license' their immunosuppressive functions. Recent studies in animal models of ocular surface disease have demonstrated the potential of MSC-derived therapies to limit inflammation and promote tissue repair. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.01.006DOI Listing
January 2019
1 Read

Dry Eye Disease: Consideration for Women's Health.

J Womens Health (Larchmt) 2019 Jan 29. Epub 2019 Jan 29.

6 Division of Cornea and Refractive Surgery, Department of Ophthalmology, Duke University Eye Center , Durham, North Carolina.

Dry eye disease (DED) is a multifactorial disorder of the ocular surface and tear homeostasis that can result in discomfort, pain, and visual disturbance. Untreated, DED can become chronic, progressive, and significantly affect an individual's quality of life. Women are disproportionately affected by DED, are diagnosed at a younger age, and experience more severe symptoms compared with men. Read More

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http://dx.doi.org/10.1089/jwh.2018.7041DOI Listing
January 2019

Nanomaterials as potential and versatile platform for next generation tissue engineering applications.

J Biomed Mater Res B Appl Biomater 2019 Jan 28. Epub 2019 Jan 28.

Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India.

Tissue engineering (TE) is an emerging field where alternate/artificial tissues or organ substitutes are implanted to mimic the functionality of damaged or injured tissues. Earlier efforts were made to develop natural, synthetic, or semisynthetic materials for skin equivalents to treat burns or skin wounds. Nowadays, many more tissues like bone, cardiac, cartilage, heart, liver, cornea, blood vessels, and so forth are being engineered using 3-D biomaterial constructs or scaffolds that could deliver active molecules such as peptides or growth factors. Read More

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http://dx.doi.org/10.1002/jbm.b.34327DOI Listing
January 2019
1 Read

Autophagy in corneal health and disease: A concise review.

Ocul Surf 2019 Jan 25. Epub 2019 Jan 25.

Harry S. Truman Memorial Veteran Hospital, Columbia, MO, United States; One-Health One-Medicine Vision Research Center, University of Missouri, Columbia, MO, United States; College of Veterinary Medicine, University of Missouri, Columbia, MO, United States; Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO, United States. Electronic address:

Autophagy is a well-conserved self-eating mechanism of cell survival during periods of nutrient deprivation, stress and injury. Autophagy is implicated in many pathophysiological conditions across all organ systems. The cornea is an avascular transparent tissue that is prone to damage by trauma, injury and infection. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.01.008DOI Listing
January 2019
1 Read

Cell sheet tissue engineering: cell sheet preparation, harvesting/manipulation and transplantation.

J Biomed Mater Res A 2019 Jan 26. Epub 2019 Jan 26.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, TWIns, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan.

Cell sheet tissue engineering is a concept for creating transplantable two-dimensional (2D) and three-dimensional (3D) tissues and organs. This review describes three elements of cell sheet tissue engineering in terms of the chemical and physical effects of material surfaces and the interfacial properties of cell sheets: preparation, harvesting/manipulation and transplantation of cell sheets. An essential technology for the preparation of cell sheets is the use of a temperature-responsive cell culture surface, where the surface of tissue culture polystyrene (TCPS) dish is modified with thin layer of temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). Read More

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http://dx.doi.org/10.1002/jbm.a.36627DOI Listing
January 2019
3 Reads

Sjögren's Syndrome: More Than Just Dry Eye.

Cornea 2019 Jan 22. Epub 2019 Jan 22.

Department of Health Services, Policy, and Practice, Center for Evidence Synthesis in Health, Brown University School of Public Health, Providence, RI.

Purpose: Sjögren's syndrome (SS) is a common autoimmune disease affecting about four million Americans. Although approximately 1 in 10 patients with clinically-significant aqueous deficient dry eye has underlying SS, widespread underappreciation of SS leads to significant underdiagnosis, delays in diagnosis, and consequent morbidity and mortality. The purpose of this article is to illustrate that in addition to dry eye, SS can cause serious, vision-threatening extraglandular ocular manifestations. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001865DOI Listing
January 2019
3 Reads

Influence of Lens Status on Outcomes of Descemet Membrane Endothelial Keratoplasty.

Cornea 2019 Jan 21. Epub 2019 Jan 21.

Division of Cornea and Refractive Surgery, Department of Ophthalmology, Duke University Eye Center, Durham, NC.

Purpose: To evaluate whether lens status influences clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) in patients who underwent DMEK in phakia, pseudophakia, or combined with cataract surgery (triple).

Methods: A retrospective review of 139 eyes (107 patients) with symptomatic Fuchs' dystrophy or secondary corneal edema was performed. Patients were divided into 3 groups: 1) DMEK + cataract surgery, 2) DMEK in pseudophakia, and 3) DMEK in phakia. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001872DOI Listing
January 2019
4 Reads

Feasibility of Intraocular Projection for Treatment of Intractable Corneal Opacity.

Cornea 2019 Jan 16. Epub 2019 Jan 16.

Department of Ophthalmology and Visual Sciences, The University of Illinois Chicago, Chicago, IL.

Despite many decades of research and development, corneal opacity remains a leading cause of reversible blindness worldwide. Corneal transplantation and keratoprosthesis can restore corneal clarity, but both have well-known limitations. High-resolution electronic microdisplays may offer an alternative to traditional methods of treating corneal disease using an intraocular implant to project imagery onto the retina, obviating the need for a clear cornea. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001852DOI Listing
January 2019
2 Reads

Challenges in management of epidemic keratoconjunctivitis with emerging recombinant human adenoviruses.

J Clin Virol 2019 Jan 11;112:1-9. Epub 2019 Jan 11.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan; Department of Ophthalmology, Health Sciences University of Hokkaido, Sapporo, Japan. Electronic address:

Adenoviral epidemic keratoconjunctivitis (EKC) presents as severe conjunctival inflammations involving the cornea that can lead to the development of corneal opacities and blurred vision, which can persist for months. EKC is highly contagious and responsible for outbreaks worldwide, therefore accurate diagnosis and rapid containment are imperative. EKC is caused by a number of types within Human adenovirus species D (HAdV-D): 8, 37 and 64 (formerly known as 19a) and these types were considered the major causes of EKC for over fifty years. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.01.004DOI Listing
January 2019

Review and analysis of grading scales for ocular surface staining.

Ocul Surf 2019 Jan 14. Epub 2019 Jan 14.

Department of Ophthalmology, HealthPartners Medical Group, Bloomington, MN, USA.

Vital dye staining has been used for over a century to assess the severity of ocular surface disease. However, despite common usage, a universally accepted "gold standard" grading scale does not exist for corneal and conjunctival staining, which can impact the ability to diagnose and monitor ocular surface conditions such as dry eye. The Food and Drug Administration (FDA) and other international regulatory agencies rely on ocular surface staining as a primary endpoint for new drug approvals, so that absence of a "gold standard" scale may affect approval of new drug treatments. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.01.004DOI Listing
January 2019
6 Reads

Influence of diabetes mellitus on anterior segment of the eye.

Clin Interv Aging 2019 27;14:53-63. Epub 2018 Dec 27.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Diabetes mellitus (DM) has been emerging as one of the most serious health problems worldwide. Ocular complications of DM are currently one of the major causes of blindness in developed countries, among which diabetic retinopathy is relatively well studied and understood. However, although ocular surface complications of DM are common, diabetic complications of anterior segment of the eye, such as, cornea, conjunctiva, and lacrimal glands, are often overlooked. Read More

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https://www.dovepress.com/influence-of-diabetes-mellitus-on-
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http://dx.doi.org/10.2147/CIA.S190713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312050PMC
December 2018
8 Reads

Medical interventions for traumatic hyphema.

Cochrane Database Syst Rev 2019 01 14;1:CD005431. Epub 2019 Jan 14.

Department of Special Surgery-Ophthalmology, Faculty of Medicine, The University of Jordan, P.O. Box 13046, Amman, Jordan.

Background: Traumatic hyphema is the entry of blood into the anterior chamber (the space between the cornea and iris) subsequent to a blow or a projectile striking the eye. Hyphema uncommonly causes permanent loss of vision. Associated trauma (e. Read More

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http://doi.wiley.com/10.1002/14651858.CD005431.pub4
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http://dx.doi.org/10.1002/14651858.CD005431.pub4DOI Listing
January 2019
4 Reads

Imaging in myopia: potential biomarkers, current challenges and future developments.

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Singapore National Eye Centre, Singapore, Singapore.

Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal neovascularisation detection, while multimodal imaging is important for monitoring treatment response. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
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http://dx.doi.org/10.1136/bjophthalmol-2018-312866DOI Listing
January 2019
7 Reads
2.976 Impact Factor

Anterior segment optical coherence tomography and its clinical applications: a review.

Clin Exp Optom 2019 Jan 12. Epub 2019 Jan 12.

Faculty of Medicine and Health, Save Sight Institute, The University of Sydney, Sydney Eye Hospital, Sydney, New South Wales, Australia.

Anterior segment optical coherence tomography (AS-OCT) has become one of the cornerstones of non-contact imaging modalities for assessing such structures as the cornea, anterior chamber angle, aqueous outflow pathway, sclera, and ocular surface structures. As such, it has a broad range of clinical applications, which have been independently reported in the literature. This paper aims to present a review of extant literature on the utility of AS-OCT and its efficacy in clinical applications, and to evaluate the quality of available evidence. Read More

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http://doi.wiley.com/10.1111/cxo.12869
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http://dx.doi.org/10.1111/cxo.12869DOI Listing
January 2019
4 Reads

The application of human amniotic membrane in the surgical management of limbal stem cell deficiency.

Ocul Surf 2019 Jan 8. Epub 2019 Jan 8.

Stein Eye Institute, Cornea Division, David Geffen School of Medicine, University of California, Los Angeles, USA. Electronic address:

The application of human amniotic membrane (AM) has a wide spectrum of indications in the treatment of ocular surface disorders. Transplantation of AM has been incorporated routinely as a component of ocular surface reconstruction in a variety of ocular pathologies. The application of human AM can be combined with nearly all types of limbal transplantation in treating limbal stem cell deficiency (LSCD). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15420124183028
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http://dx.doi.org/10.1016/j.jtos.2019.01.003DOI Listing
January 2019
6 Reads

Strategies for reconstructing the limbal stem cell niche.

Ocul Surf 2019 Jan 8. Epub 2019 Jan 8.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address:

The epithelial cell layer that covers the surface of the cornea provides a protective barrier while maintaining corneal transparency. The rapid and effective turnover of these epithelial cells depends, in part, on the limbal epithelial stem cells (LESCs) located in a specialized microenvironment known as the limbal niche. Many disorders affecting the regeneration of the corneal epithelium are related to deficiency and/or dysfunction of LESCs and the limbal niche. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.01.002DOI Listing
January 2019
1 Read

Clinical Characteristics of Autosomal Dominant GJA1 Missense Mutation Linked to Oculodentodigital Dysplasia in a Korean Family.

J Glaucoma 2019 Jan 8. Epub 2019 Jan 8.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: We aimed to present a comprehensive assessment of the ophthalmic characteristics of genetically confirmed oculodentodigital dysplasia (ODDD) in four members of a single Korean family across three generations.

Patients And Methods: The characteristics of four affected ODDD patients were evaluated. Comprehensive ophthalmic and medical examinations were performed in three patients including the proband, together with genetic analysis, and retrospective chart review was conducted for an affected ancestor. Read More

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http://Insights.ovid.com/crossref?an=00061198-900000000-9822
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http://dx.doi.org/10.1097/IJG.0000000000001190DOI Listing
January 2019
3 Reads

Trehalose in ophthalmology.

Histol Histopathol 2019 Jan 9:18082. Epub 2019 Jan 9.

Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.

Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is synthetized by many organisms when cells are exposed to stressful conditions, including dehydration, heat, oxidation, hypoxia or even anoxia. Although trehalose is not synthesized by mammalian cells, it has recently been demonstrated to have a number of important properties that indicate its utility in humans. Read More

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http://dx.doi.org/10.14670/HH-18-082DOI Listing
January 2019
3 Reads

A Multicenter Study Evaluating the Risk Factors and Outcomes of Repeat Descemet Stripping Endothelial Keratoplasty.

Cornea 2019 Feb;38(2):177-182

Department of Ophthalmology, Loyola University Medical Center, Maywood, IL.

Purpose: Descemet stripping endothelial keratoplasty (DSEK), currently the most common procedure for managing corneal endothelial dysfunction, may be repeated following DSEK failure from a variety of causes. This multicenter study reports the risk factors and outcomes of repeat DSEK.

Methods: This was an institutional review board-approved multicenter retrospective chart review of patients who underwent repeat DSEK. Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9667
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http://dx.doi.org/10.1097/ICO.0000000000001817DOI Listing
February 2019
6 Reads

Novel Use of Telemedicine for Corneal Tissue Evaluation in Eye Banking: Establishing a Standardized Approach for the Remote Evaluation of Donor Corneas for Transplantation.

Cornea 2018 Dec 31. Epub 2018 Dec 31.

Department of Ophthalmology, Weill Cornell Medical College, New York, NY.

Purpose: To determine the feasibility of using telemedicine consultations in the evaluation of recovered donor corneas for transplant suitability.

Methods: This study aims to establish and test the minimum imaging requirements for telemedical consultations of corneal tissue by remote eye bank medical directors. Digital images from the slit lamp, optical coherence tomography, and/or specular microscope were assembled into telemedical consults and emailed to 4 eye bank medical directors (M. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001848DOI Listing
December 2018
3 Reads

Advances in culture, expansion and mechanistic studies of corneal endothelial cells: a systematic review.

J Biomed Sci 2019 Jan 4;26(1). Epub 2019 Jan 4.

Tissue Tech, Inc., 7235 Corporate Center Drive, Suite B, Miami, Florida, 33126, USA.

Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo and in vitro. Hence, injury or dysfunction of these cells may easily result in blindness. Currently, the only treatment is to transplant a donor cornea that contains a healthy corneal endothelium. Read More

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https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929
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http://dx.doi.org/10.1186/s12929-018-0492-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320592PMC
January 2019
6 Reads
2.736 Impact Factor

Reports of Post-keratoplasty Infections for Eye Bank-prepared and Non-Eye Bank-prepared Corneas: 12 Years of Data From a Single Eye Bank.

Cornea 2019 Mar;38(3):263-267

Lions VisionGift, Portland, OR.

Purpose: To examine postoperative reports of infection rates for eye bank-prepared and non-eye bank-prepared corneas from January 1, 2006 to December 31, 2017, from a single eye bank.

Method: A retrospective review of reported fungal and bacterial infections with corneal transplant surgeries using corneas distributed by our eye bank was conducted. The reported number of infections for corneas that underwent eye bank preparation (pre-cut and pre-stripped corneas) and for those distributed without eye bank preparation was quantified. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001839DOI Listing
March 2019
1 Read

The Persistent Dilemma of Microbial Keratitis: Global Burden, Diagnosis, and Antimicrobial Resistance.

Surv Ophthalmol 2018 Dec 24. Epub 2018 Dec 24.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA; Infectious Disease Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Microbial keratitis (MK) is a potentially blinding condition which must be treated emergently to preserve vision. Although long recognized as a significant cause of corneal blindness, our understanding of its true global scale, associated burden of disease, and etiological patterns remains somewhat limited. Current epidemiological data suggests that MK may be epidemic in parts of the world--particularly within South, South-East and East Asia--and may exceed two million cases per year world-wide. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396257183021
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http://dx.doi.org/10.1016/j.survophthal.2018.12.003DOI Listing
December 2018
9 Reads

Research progress about the effect and prevention of blue light on eyes.

Int J Ophthalmol 2018 18;11(12):1999-2003. Epub 2018 Dec 18.

Department of Ophthalmology, Xi'an No.4 Hospital, Xi'an 710004, Shaanxi Province, China.

In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.12.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288536PMC
December 2018
11 Reads

Monitoring the microbial contamination of donor cornea during all preservation phases: A prospective study in the Eye Bank of Rome.

Transpl Infect Dis 2018 Dec 24:e13041. Epub 2018 Dec 24.

Eye Bank of Rome, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy.

Background: In most European eye banks, human donor corneas are microbiologically tested after storage in organ culture conditions, and the tissues that are free of contamination are distributed for transplantation. In this prospective study, 100 donor corneas were tested for microbial contamination after cold storage, corneal culture and corneal deswelling at the Eye Bank of Rome.

Methods: Samples of cold storage medium (EUSOL-C), corneal culture medium (TISSUE-C) and deswelling medium (CARRY-C) were tested after three, seven and one days of corneal storage, respectively. Read More

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http://dx.doi.org/10.1111/tid.13041DOI Listing
December 2018
3 Reads

Keratan sulfate (KS)-proteoglycans and neuronal regulation in health and disease: the importance of KS-glycodynamics and interactive capability with neuroregulatory ligands.

Authors:
James Melrose

J Neurochem 2018 Dec 22. Epub 2018 Dec 22.

Raymond Purves Bone and Joint Research Laboratory, Kolling Institute, St. Leonards, New South Wales, Australia.

Compared to the other classes of glycosaminoglycans (GAGs), that is, chondroitin/dermatan sulfate, heparin/heparan sulfate and hyaluronan, keratan sulfate (KS), have the least known of its interactive properties. In the human body, the cornea and the brain are the two most abundant tissue sources of KS. Embryonic KS is synthesized as a linear poly-N-acetyllactosamine chain of d-galactose-GlcNAc repeat disaccharides which become progressively sulfated with development, sulfation of GlcNAc is more predominant than galactose. Read More

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http://doi.wiley.com/10.1111/jnc.14652
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http://dx.doi.org/10.1111/jnc.14652DOI Listing
December 2018
7 Reads

Crystalline Keratopathy in Post-LASIK Ectasia: A Case Report.

Cornea 2018 Dec 19. Epub 2018 Dec 19.

Department of Ophthalmology, McGill University, Montreal, QC, Canada.

Purpose: To report an unusual case of bilateral crystalline keratopathy presenting several years after a laser in situ keratomileusis (LASIK) procedure.

Methods: Case report and review of the literature.

Results: A healthy 42-year-old woman with post-LASIK ectasia, treated with long-term corneoscleral contact lenses, developed new-onset crystalline keratopathy in both eyes. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001849DOI Listing
December 2018
1 Read

Current concepts in crosslinking thin corneas.

Indian J Ophthalmol 2019 Jan;67(1):8-15

Cornea, Cataract and Refractive Services, Centre for Sight Hospital, New Delhi, India.

Corneal cross-linking (CXL), introduced by Wollensak et al. in 2003, is a minimally invasive procedure to halt the progression of keratoconus. Conventional CXL is recommended in eyes with corneal thickness of at least 400 microns after de-epithelialization to prevent endothelial toxicity. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1403_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324097PMC
January 2019
0.927 Impact Factor

Tissue-Engineered Grafts from Human Decellularized Extracellular Matrices: A Systematic Review and Future Perspectives.

Int J Mol Sci 2018 Dec 18;19(12). Epub 2018 Dec 18.

Department of Neuroscience, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy.

Tissue engineering and regenerative medicine involve many different artificial and biologic materials, frequently integrated in composite scaffolds, which can be repopulated with various cell types. One of the most promising scaffolds is decellularized allogeneic extracellular matrix (ECM) then recellularized by autologous or stem cells, in order to develop fully personalized clinical approaches. Decellularization protocols have to efficiently remove immunogenic cellular materials, maintaining the nonimmunogenic ECM, which is endowed with specific inductive/differentiating actions due to its architecture and bioactive factors. Read More

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http://dx.doi.org/10.3390/ijms19124117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321114PMC
December 2018
1 Read
2.862 Impact Factor

Glaucoma in children with facial port wine stain.

Eur J Ophthalmol 2018 Dec 19:1120672118819668. Epub 2018 Dec 19.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose:: To report on the clinical presentation and surgical treatment (procedure and outcome(s)) of glaucoma in children with facial port wine stain.

Materials And Methods:: This is a retrospective chart review of children with facial port wine stain referred to Alexandria University paediatric ophthalmology practice from 2005 to 2016. The charts of 22 children (44 eyes) with facial port wine stain were reviewed. Read More

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http://dx.doi.org/10.1177/1120672118819668DOI Listing
December 2018
3 Reads
1.058 Impact Factor

Corneal endothelial cell dysfunction: etiologies and management.

Authors:
Sepehr Feizi

Ther Adv Ophthalmol 2018 Jan-Dec;10:2515841418815802. Epub 2018 Dec 7.

Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran 16666, Iran.

A transparent cornea is essential for the formation of a clear image on the retina. The human cornea is arranged into well-organized layers, and each layer plays a significant role in maintaining the transparency and viability of the tissue. The endothelium has both barrier and pump functions, which are important for the maintenance of corneal clarity. Read More

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http://dx.doi.org/10.1177/2515841418815802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293368PMC
December 2018
7 Reads

Deep anterior lamellar keratoplasty: A surgeon's guide.

J Curr Ophthalmol 2018 Dec 10;30(4):297-310. Epub 2018 Jul 10.

Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Brighton, United Kingdom.

Purpose: To review and highlight important practical aspects of deep anterior lamellar keratoplasty (DALK) surgery and provide some useful tips for surgeons wishing to convert to this procedure from the conventional penetrating keratoplasty (PK) technique.

Methods: In this narrative review, the procedure of DALK is described in detail. Important pre, intra, and postoperative considerations are discussed with illustrative examples for better understanding. Read More

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http://dx.doi.org/10.1016/j.joco.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276733PMC
December 2018

Gene-based therapeutic tools in the treatment of Cornea Disease.

Curr Gene Ther 2018 Dec 13. Epub 2018 Dec 13.

Tianjin Medical University Eye Hospital, The College of Optometry, Tianjin 300384. China.

Background: As one of the main blinding ocular diseases, corneal blindness results from neovascularization that disrupts the angiogenic privilege of corneal avascularity. Following neovascularization, inflammatory cells are infiltrating into corneal to strengthen corneal injury. How to maintain corneal angiogenic privilege to treat corneal disease has been investigated for decades. Read More

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http://dx.doi.org/10.2174/1566523219666181213120634DOI Listing
December 2018
2 Reads

[Corneal deposits in monoclonal gammopathy of undetermined significance. Review of the literature and case report].

Orv Hetil 2018 Sep;159(39):1575-1583

Szemészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.

To summarize ophthalmological signs of monoclonal gammopathy of undetermined significance (MGUS) and to present a case report. Summary of the literature data and presentation of the history of a 46-year-old female patient. In MGUS, pathological, but non-malignant plasma cells produce abnormal monoclonal immunoglobulin. Read More

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http://dx.doi.org/10.1556/650.2018.31196DOI Listing
September 2018
2 Reads

Suction Stability Management in SMILE: Development of a Decision Tree for Managing Eye Movements and Suction Loss.

J Refract Surg 2018 Dec;34(12):809-816

Purpose: To develop a comprehensive protocol for suction stability management during small incision lenticule extraction (SMILE).

Methods: This was a retrospective video review of all SMILE cases where suction loss occurred or eye movement was noted in the medical record. The different types of eye movement were collated. Read More

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http://dx.doi.org/10.3928/1081597X-20181023-01DOI Listing
December 2018