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    Organ-specific biomarkers in lupus.
    Autoimmun Rev 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China. Electronic address:
    Systemic lupus erythematosus (SLE) is a complex and highly heterogeneous disease, which affects multiple organs, including joints, skin, kidneys, heart, hematopoietic system, and nerve system. While the etiopathogenesis of SLE still remains unclear, genetic susceptibilities and aberrant epigenetic modifications are believed to be involved. For precision therapy, it is necessary to assess accurately and objectively organ involvements and disease activity, which is difficult by current clinical laboratory tests. Read More

    Neonatal lupus: Follow-up in infants with anti-SSA/Ro antibodies and review of the literature.
    Autoimmun Rev 2017 Feb 14. Epub 2017 Feb 14.
    Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy.
    Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clinical manifestations: complete congenital heart block (CCHB) and cutaneous lupus are the most common, while hepatobiliary disease, hematological manifestations and central nervous system involvement may occur. Read More

    Burden and treatment patterns of invasive fungal infections in hospitalized patients in the Middle East: real-world data from Saudi Arabia and Lebanon.
    Infect Drug Resist 2017 2;10:35-41. Epub 2017 Feb 2.
    Real-world Evidence/Data Analytics Center of Excellence, Pharmerit International, Bethesda, MD, USA.
    Objectives: The objective of this study was to document the burden and treatment patterns associated with invasive fungal infections (IFIs) due to Candida and Aspergillus species in Saudi Arabia and Lebanon.

    Methods: A retrospective chart review study was conducted using data recorded from 2011 to 2012 from hospitals in Saudi Arabia and Lebanon. Patients were included if they had been discharged with a diagnosis of IFI due to Candida or Aspergillus, which was culture proven or suspected based on clinical criteria. Read More

    Early disease progression of Hurler syndrome.
    Orphanet J Rare Dis 2017 Feb 14;12(1):32. Epub 2017 Feb 14.
    Program for the Study of Neurodevelopment in Rare Disorders, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA, 15224, USA.
    Background: Newborn screening for mucopolysaccharidosis type I (MPS I) shows promise to improve outcomes by facilitating early diagnosis and treatment. However, diagnostic tests for MPS I are of limited value in predicting whether a child will develop severe central nervous system disease associated with Hurler syndrome, or minimal or no central nervous system involvement associated with the attenuated phenotypes (Hurler-Scheie and Scheie syndromes). Given that the optimal treatment differs between Hurler syndrome and the attenuated MPS I phenotypes, the absence of a reliable prognostic biomarker complicates clinical decision making for infants diagnosed through newborn screening. Read More

    Team work and cytopathology molecular diagnosis of solid pancreatic lesions: A review.
    Dig Endosc 2017 Feb 11. Epub 2017 Feb 11.
    Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Bologna, Italy.
    Pancreatic ductal adenocarcinoma (PDAC) is supposed to become the second leading cancer-associated death by the next years. It is widely accepted that tumorigenesis is linked to specific alterations in key genes and pancreatic neoplasms are some of the best characterized at the genomic level. Recent whole-exome and whole-genome sequencing analyses confirmed that PDAC is frequently characterized by mutations in a set of four genes among the others: KRAS, TP53, CDKN2A/p16, and SMAD4. Read More

    Alkaline Phosphatase: A Biomarker of Cardiac Function in Pediatric Patients.
    Pediatr Cardiol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Myocardial dysfunction and heart failure are common in pediatric patients with congenital and acquired heart disease. Alkaline phosphatase (AP) has been suggested as a biomarker for myocardial dysfunction after Fontan operation. We hypothesized that pediatric patients with myocardial dysfunction requiring orthotopic heart transplant (OHT) have diminished AP compared to normal. Read More

    Physiological responses during the practice of synchronized swimming: a systematic review.
    Clin Physiol Funct Imaging 2017 Feb 6. Epub 2017 Feb 6.
    Translational Physiology Laboratory, Postgraduation in Physical Education of Sao Judas Tadeu University, Sao Paulo, SP, Brazil.
    This study is aimed at analysing the scientific literature related to physiological responses in synchronized swimmers, produced from 2006 to 2016. A systematic review was conducted using electronic databases (Google Scholar, PubMed, SportDiscus, Web Science, Scielo and Scopus) in national and international journals. The articles were selected using the following inclusion criteria: composed samples of synchronized swimmers of both sexes, articles in English, Spanish and Portuguese, published from 2006 to 2016. Read More

    Retrospective study of prognostic factors in pediatric invasive pneumococcal disease.
    PeerJ 2017 25;5:e2941. Epub 2017 Jan 25.
    Hsinchu MacKay Memorial Hospital , Hsinchu , Taiwan.
    Streptococcus pneumoniae remains the leading causative pathogen in pediatric pneumonia and bacteremia throughout the world. The invasive pneumococcal disease (IPD) is known as isolation of S. pneumoniae from a normally sterile site (e. Read More

    The Impact of the Right Ventricular Outflow Tract Patch on Right Ventricular Strain in Tetralogy of Fallot: A Comparison with Valvar Pulmonary Stenosis Utilizing Cardiac Magnetic Resonance.
    Pediatr Cardiol 2017 Jan 31. Epub 2017 Jan 31.
    Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia PA. 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
    A non-contractile transannular patch (TAP) in the right ventricular outflow tract (RVOT) contributes to ventricular dysfunction after tetralogy of Fallot (TOF) repair. We compared regional right ventricular (RV) strain in repaired TOF with valvar pulmonary stenosis (VPS) after balloon valvuloplasty to investigate the effects of TAP. Retrospective review of 26 cardiac magnetic resonance studies of TOF (n = 13) and VPS (n = 13) subjects matched by degree and duration of pulmonary regurgitation (PR). Read More

    Fetal Echocardiographic Findings in Right Pulmonary Artery to Left Atrium Communication: A Case Report and Review of the Literature.
    J Matern Fetal Neonatal Med 2017 Jan 31:1-15. Epub 2017 Jan 31.
    a Department of Perinatology and Gynecology , National Cerebral and Cardiovascular Center , Suita , Japan.
    Right pulmonary artery to left atrium communication (RPALA com) is a fatal congenital heart disease with right-to-left shunting. We present a rare case of RPALA com that was prenatally diagnosed and confirmed by autopsy. We focus on some unique echocardiographic findings for prenatal diagnosis of RPALA com by reviewing our case and the literature. Read More

    Corticosteroids for the treatment of Kawasaki disease in children.
    Cochrane Database Syst Rev 2017 Jan 27;1:CD011188. Epub 2017 Jan 27.
    Congenital Heart Disease, Bristol Royal Hospital for Children and Bristol Heart Institute, Upper Maudlin Street, Bristol, UK, BS2 8BJ.
    Background: Kawasaki disease (KD), or mucocutaneous syndrome, is the leading cause of childhood-acquired heart disease in the developed world. There is much controversy on how best to treat children with KD and in particular who may benefit from additional treatment beyond the standard intravenous immunoglobulin (IVIG) and aspirin, such as the addition of corticosteroids.

    Objectives: To assess the impact of corticosteroid use on the incidence of coronary artery abnormalities in KD as either first-line or second-line treatment. Read More

    [Bacteremia caused by ciprofloxacin-resistant Salmonella serotype Kentucky: a case report and the review of literature].
    Mikrobiyol Bul 2016 Oct;50(4):598-605
    Ankara Atatürk Training and Research Hospital, Medical Microbiology Laboratory, Ankara, Turkey.
    Salmonella infections can be seen in four clinical types, namely gastroenteritis, bacteremia/sepsis, enteric fever and carriage. These infections can result in uncomplicated diarrhea in most cases, but can lead to invasive disease requiring antimicrobial therapy and can be life-threatening in elderly or immunocomprimised patients. Broad-spectrum cephalosporins and fluoroquinolones are crucial options in the treatment of the invasive infections. Read More

    Clinical and historical features of emergency department patients with pericardial effusions.
    World J Emerg Med 2017 ;8(1):29-33
    Department of Emergency Medicine, University of Arizona, Tucson, AZ 85721, USA.
    Background: Diagnosing pericardial effusion is critical for optimal patient care. Typically, clinicians use physical examination findings and historical features suggesting pericardial effusion to determine which patients require echocardiography. The diagnostic characteristics of these tools are not well described. Read More

    Prognostic significance of exercise-induced premature ventricular complexes: a systematic review and meta-analysis of observational studies.
    Heart Asia 2017 4;9(1):14-24. Epub 2017 Jan 4.
    University College London , London , UK.
    Background: Exercise-induced premature ventricular complexes (EI-PVCs) are common during exercise stress tests. Their optimal management and prognostic significance remain uncertain.

    Aim: To perform meta-analysis of observational studies on the prognostic significance of EI-PVCs. Read More

    Cardiovascular disease in cancer survivors.
    Postgrad Med J 2017 Feb 8;93(1096):82-90. Epub 2016 Oct 8.
    Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, Illinois, USA.
    Certain cancer therapies, including radiation therapy and some types of chemotherapies, are associated with increased risk of cardiovascular disease (CVD) and events. Some of these effects such as those presented by anthracyclines, radiation therapy, cisplatin, as well as those presented by hormone therapy for breast cancer-usually taken for many years for some breast and prostate cancers-are long-lasting and associated with cardiovascular events risk more than 20 years after cancer treatment. Cardiovascular testing, diagnostic assessment of suspected cardiovascular symptomatology, as well as laboratory tests for CVD risk factors are imperative. Read More

    Pharmacological Tests in Atrial Fibrillation Ablation.
    Arrhythm Electrophysiol Rev 2016 ;5(3):170-176
    Electrophysiology Service, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada.
    The invasive management of atrial fibrillation (AF) has been considerably changed by the identification of major sites of AF initiation and/or maintenance within the pulmonary vein antra. Percutaneous catheter ablation of these targets has become the standard of care for sustained maintenance of sinus rhythm. Long-term failure of ablation is related to an inability to create a durable transmural lesion or to identify all of the non-pulmonary vein arrhythmia triggers. Read More

    Does N-terminal Pro-brain Type Natriuretic Peptide Predict Cardiac Complications After Hip Fracture Surgery?
    Clin Orthop Relat Res 2017 Jan 18. Epub 2017 Jan 18.
    Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Higashi-Ku, Hamamatsu, Shizuoka, Japan.
    Background: Elderly patients with hip fracture are at risk for cardiac complications. N-terminal pro-brain type natriuretic peptide (NT-proBNP) has been shown to predict cardiac complications in surgical patients; however, to our knowledge, only two studies have evaluated the utility of this test in patients with hip fracture. We believe it is important to assess a more accurate cutoff value of NT-proBNP with exclusion of patients with renal failure. Read More

    Natural history of nonimmune-mediated thrombocytopenia and acute kidney injury in pediatric open-heart surgery.
    Paediatr Anaesth 2017 Jan 18. Epub 2017 Jan 18.
    Pediatric Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
    Objective: Thrombocytopenia and acute kidney injury (AKI) are common following pediatric cardiac surgery with cardiopulmonary bypass (CPB). However, the relationship between postoperative nadir platelet counts and AKI has not been investigated in the pediatric population. Our objective was to investigate this relationship and examine independent predictors of AKI. Read More

    The Differential Diagnosis of Dyspnea.
    Dtsch Arztebl Int 2016 Dec;113(49):834-845
    Department of Cardiology and Angiology, Hannover Medical School; Institute for General Practice, Hannover Medical School; Department of Respiratory Medicine, Hannover Medical School.
    Background: Dyspnea is a common symptom affecting as many as 25% of patients seen in the ambulatory setting. It can arise from many different underlying conditions and is sometimes a manifestation of a life-threatening disease.

    Methods: This review is based on pertinent articles retrieved by a selective search in PubMed, and on pertinent guidelines. Read More

    The use of therapeutic magnesium for neuroprotection during global cerebral ischemia associated with cardiac arrest and cardiac surgery in adults: a systematic review.
    JBI Database System Rev Implement Rep 2017 Jan;15(1):86-118
    1Joanna Briggs Institute, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia 2School of Medical Sciences, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia 3School of Nursing, Midwifery and Paramedicine, Australian Catholic University, Canberra, Australia.
    Background: Global cerebral ischemia occurs due to reduced blood supply to the brain. This is commonly caused by a cessation of myocardial activity associated with cardiac arrest and cardiac surgery. Survival is not the only important outcome because neurological dysfunction impacts on quality of life, reducing independent living. Read More

    Evaluating the survivor or the relatives of those who do not survive: the role of genetic testing.
    Cardiol Young 2017 Jan;27(S1):S19-S24
    Departments of Cardiovascular Diseases,Pediatrics and Molecular Pharmacology & Experimental Therapeutics,Divisions of Heart Rhythm Services and Pediatric Cardiology,Windland Smith Rice Sudden Death Genomics Laboratory,Mayo Clinic,Rochester,Minnesota,United States of America.
    The molecular millennium has bestowed clinicians and researchers with the essential tools to identify the underlying genetic substrates for thousands of genetic disorders, most of which are rare and follow Mendelian inheritance patterns. The genetic basis of potentially lethal and heritable cardiomyopathies and cardiac channelopathies has been identified and are now better understood. Genetic testing for several of these heritable conditions has made its transition from discovery through translation and have been commercially available clinical tests for over a decade. Read More

    Sudden cardiac death in the young: the value of exercise testing.
    Cardiol Young 2017 Jan;27(S1):S10-S18
    Division of Cardiology,The Children's Hospital of Philadelphia,Philadelphia,Pennsylvania,United States of America.
    Paediatric exercise stress testing has historically been used to assess the functional status of patients after repair of CHDs and to assess the efficacy of medical or device therapy in patients with arrhythmias. Exercise stress testing is one of very few hospital- or clinic-based tests that can assess the response of the cardiopulmonary system in an environment that simulates the body's response to vigorous play and competitive sport. Exercise stress testing is therefore a useful modality in the assessment of child and athletes at risk for sudden cardiac death. Read More

    Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk?
    Sleep Med Rev 2016 Nov 10. Epub 2016 Nov 10.
    Sleep Disorder Unit, Pitie-Salpetriere Hospital, APHP, Pierre and Marie Curie University, Paris, France. Electronic address:
    Most people with idiopathic REM sleep behavior disorder (iRBD) have an underlying synucleinopathy, mainly Parkinson's disease (PD) or dementia with Lewy bodies, with median conversion time of 4-9 y from iRBD diagnosis and of 11-16 y from symptom onset. Subtle signs and imaging tests indicate concomitant neurodegeneration in widespread brain areas. Risk factor studies suggest that iRBD patients may have prior head injury, occupational farming, pesticide exposure, low education level and possibly more frequent family history of dream-enactment behavior (but not of PD), plus unexpected risk factors (smoking, ischemic heart disease and inhaled corticosteroid use). Read More

    Use of Biomarkers in Predicting the Onset, Monitoring the Progression, and Risk Stratification for Patients with Type 2 Diabetes Mellitus.
    Clin Chem 2017 Jan;63(1):186-195
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
    Background: As the worldwide prevalence of type 2 diabetes mellitus (T2DM) increases, it is even more important to develop cost-effective methods to predict and diagnose the onset of diabetes, monitor progression, and risk stratify patients in terms of subsequent cardiovascular and diabetes complications.

    Content: Nonlaboratory clinical risk scores based on risk factors and anthropomorphic data can help identify patients at greatest risk of developing diabetes, but glycemic indices (hemoglobin A1c, fasting plasma glucose, and oral glucose tolerance tests) are the cornerstones for diagnosis, and the basis for monitoring therapy. Although family history is a strong predictor of T2DM, only small populations of patients carry clearly identifiable genetic mutations. Read More

    Organ transplantation and drug eluting stents: Perioperative challenges.
    World J Transplant 2016 Dec;6(4):620-631
    Aparna Dalal, Department of Anesthesiology, Icahn School of Medicine, New York, NY 10029, United States.
    Patients listed for organ transplant frequently have severe coronary artery disease (CAD), which may be treated with drug eluting stents (DES). Everolimus and zotarolimus eluting stents are commonly used. Newer generation biolimus and novolimus eluting biodegradable stents are becoming increasingly popular. Read More

    Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.
    Int J Cardiol 2017 Mar 21;230:384-401. Epub 2016 Dec 21.
    Department of Surgery, Duke University School of Medicine, Durham, NC, 27710, USA. Electronic address:
    For most of Medicine's past, the best that physicians could do to cope with disease prevention and treatment was based on the expected response of an average patient. Currently, however, a more personalized/precise approach to cardiology and medicine in general is becoming possible, as the cost of sequencing a human genome has declined substantially. As a result, we are witnessing an era of precipitous advances in biomedicine and bourgeoning understanding of the genetic basis of cardiovascular and other diseases, reminiscent of the resurgence of innovations in physico-mathematical sciences and biology-anatomy-cardiology in the Renaissance, a parallel time of radical change and reformation of medical knowledge, education and practice. Read More

    Iron Therapy in Patients with Heart Failure and Iron Deficiency: Review of Iron Preparations for Practitioners.
    Am J Cardiovasc Drugs 2016 Dec 30. Epub 2016 Dec 30.
    Cardiology Department, Centre for Heart Diseases, Military Hospital, Wroclaw, Poland.
    In patients with heart failure (HF), iron deficiency (ID) correlates with decreased exercise capacity and poor health-related quality of life, and predicts worse outcomes. Both absolute (depleted iron stores) and functional (where iron is unavailable for dedicated tissues) ID can be easily evaluated in patients with HF using standard laboratory tests (assessment of serum ferritin and transferrin saturation). Intravenous iron therapy in iron-deficient patients with HF and reduced ejection fraction has been shown to alleviate HF symptoms and improve exercise capacity and quality of life. Read More

    Primarily isolated hepatic involvement of amyloidosis: A case report and overview.
    Medicine (Baltimore) 2016 Dec;95(52):e5645
    Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
    Background: Amyloidosis is particularly difficult to diagnose because the signs and symptoms are subtle. Additionally, there are no specific imaging or laboratory tests, except histopathology. Although it is considered to be a systemic disorder, a small portion of cases may be localized. Read More

    Congenital anomalies of the pulmonary arteries: spectrum of findings on computed tomography.
    Radiologia 2016 Dec 23. Epub 2016 Dec 23.
    Departamento de Radiología, Fundación Valle del Lili, Cali, Valle del Cauca, Colombia.
    Objective: Congenital anomalies of the pulmonary arteries are uncommon. They can occur in isolation or in association with congenital heart defects. Isolated congenital anomalies remain undiscovered until they are reported as incidental findings on imaging tests, usually not until adolescence. Read More

    Closing in on the PumpKIN Trial of the Jarvik 2015 Ventricular Assist Device.
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2017 Jan;20:9-15
    Jarvik Heart, Inc., New York, NY.
    The Infant Jarvik ventricular assist device (VAD; Jarvik Heart, Inc., New York, NY) has been developed to support the circulation of infants and children with advanced heart failure. The first version of the device was determined to have elevated hemolysis under certain conditions. Read More

    An unfortunate case of acquired hemochromatosis: a case report review of the clinical presentation, diagnosis, management, and prognosis.
    Int Med Case Rep J 2016 8;9:385-387. Epub 2016 Dec 8.
    Department of Pathology, Virginia College of Osteopathic Medicine-Virginia Tech, Blacksburg, VA, USA.
    Background: While blood transfusions are commonly used for prophylaxis and treatment for acute chest syndromes and strokes in sickle cell patients, accumulation of excess iron resulting in secondary hemochromatosis remains a rare disease. Chelation is the mainstay for preventing and treating iron overload to deter potential end-organ damages; it is rare when therapy fails.

    Case Report: A 52-year-old African American woman with chronic anemia secondary to sickle cell anemia and history of multiple blood transfusions presented with elevated serum ferritin (8000 ng/mL) and bilirubin (16. Read More

    An elderly male with tingly legs and a heavy heart: Persisting with the diagnosis!
    Ann Indian Acad Neurol 2016 Oct-Dec;19(4):444-447
    Department of Endocrinology, Diabetes and Bariatric Medicine, Naryanana Health City, Bengaluru, Karnataka, India.
    Pursuing a diagnosis despite a negative nerve biopsy report requires a strong clinical conviction. Paying attention to clinical details and a diligent review of medical records is needed to solve cases in which the diagnosis is not obvious despite numerous tests. We present once such case of an elderly man with chronic diarrhea, weight loss, and peripheral neuropathy and elaborate on a step by step basis on how the clinical thought process evolved after sifting through the reports of scan and tests done during his work up. Read More

    Statin use and kidney cancer survival outcomes: A systematic review and meta-analysis.
    Cancer Treat Rev 2017 Jan 27;52:105-116. Epub 2016 Nov 27.
    Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Canada. Electronic address:
    Background: Statin use has been associated with improved survival outcomes in various malignancies. Randomized controlled trials are currently underway evaluating their utility as adjunctive cancer therapies. However, studies evaluating the association between statin use and outcomes in kidney cancer yield conflicting results. Read More

    An approach to interpreting restrictive spirometric pattern results in occupational settings.
    Med Lav 2016 Dec 13;107(6):419-436. Epub 2016 Dec 13.
    Dipartimento di Medicina Clinica e Sperimentale Università degli studi di Parma.
    Objectives: The aim of this review is to provide an updated overview of definition, epidemiology, diagnostic algorithm and occupational exposures related to abnormal restrictive spirometrical pattern (RSP) in order to improve the correct interpretation of spirometry test results by occupational healthcare providers.

    Methods: A review of the scientific English literature of the last 25 years was carried out with MEDLINE and related keywords [(restricti* AND spirometr*) AND occupational]. The first step analysis covered 40 studies and the second step the reference list. Read More

    Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA(2)LEN).
    Asthma Res Pract 2016 28;2:12. Epub 2016 Oct 28.
    Allergy and Respiratory Diseases Department DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.
    Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these diseases. Starting from an extensive literature review, both organizations developed, discussed, and approved the manifesto, which was subsequently approved and endorsed by the chairs of ARIA and GA(2)LEN. The manifesto describes the evidence gathered to date and defines and proposes issues on small airway involvement and management in asthma and COPD with the aim of challenging assumptions, fostering commitment, and bringing about change. Read More

    Automated telephone communication systems for preventive healthcare and management of long-term conditions.
    Cochrane Database Syst Rev 2016 12 14;12:CD009921. Epub 2016 Dec 14.
    Centre for Population Health Sciences (CePHaS), Lee Kong Chian School of Medicine, Nanyang Technological University, 3 Fusionopolis Link, #06-13, Nexus@one-north, Singapore, Singapore, 138543.
    Background: Automated telephone communication systems (ATCS) can deliver voice messages and collect health-related information from patients using either their telephone's touch-tone keypad or voice recognition software. ATCS can supplement or replace telephone contact between health professionals and patients. There are four different types of ATCS: unidirectional (one-way, non-interactive voice communication), interactive voice response (IVR) systems, ATCS with additional functions such as access to an expert to request advice (ATCS Plus) and multimodal ATCS, where the calls are delivered as part of a multicomponent intervention. Read More

    Uncommon localizations of hydatid cyst. Review of the literature.
    G Chir 2016 Jul-Aug;37(4):180-185
    Introduction: Hydatid disease is an endemic anthropozoonosis with usual localization in liver and lungs. Rarely it localizes in uncommon sites as spleen, skeleton, kidney, brain, cardiac muscle, peritoneum, sub cutis. Complications of uncommon localizations are the same that for usual ones. Read More

    Diagnosing Myocardial Contusion after Blunt Chest Trauma.
    J Tehran Heart Cent 2016 Apr;11(2):49-54
    Department of General Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
    A myocardial contusion refers to a bruise of the cardiac muscle, the severity of which can vary depending on the severity of the injury and when the injury occurs. It is a major cause of rapid death which happens after blunt chest trauma and should be suspected at triage in the emergency department. We demonstrated that suspected myocardial contusion patients who have normal electrocardiograms (ECGs) and biomarker tests can be safely discharged. Read More

    Coronary computed tomographic angiography for patients with low-to-intermediate risk chest pain: A systematic review and meta-analysis.
    Oncotarget 2017 Jan;8(2):2096-2103
    Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Coronary computed tomographic angiography (CCTA) can image the coronary vasculature rapidly and detect the presence and severity of luminal stenosis accurately. However, whether CCTA based care strategy could gain more benefits than conventional strategy with functional tests for patients with low-to-intermediate risk chest pain remains unknown. In this study we performed a meta-analysis to compare the clinical efficacy of CCTA versus conventional strategy. Read More

    Diagnostic accuracy of treadmill exercise tests among Chinese women with coronary artery diseases: A systematic review and meta-analysis.
    Int J Cardiol 2017 Jan 9;227:894-900. Epub 2016 Nov 9.
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037), China.
    Background: The treadmill exercise test (TET) is one of the most common noninvasive diagnosis approaches for ischemic heart diseases, but potential reduction of TET accuracy among Chinese female patients was ignored by most studies, especially in perimenopause women. Hence, we aim to perform a systematic review and meta-analysis evaluating the TET diagnostic accuracy for Chinese women compared with coronary angiography (CAG).

    Methods: PubMed, MEDLINE, EMBASE, CNKI and WANFANG (1990 to 2015) were performed to identify studies assessing the diagnostic accuracy of TET versus CAG. Read More

    Aortic Root Dilatation in Mucopolysaccharidosis I-VII.
    Int J Mol Sci 2016 Nov 29;17(12). Epub 2016 Nov 29.
    Department of Pediatrics, University of California-Irvine School of Medicine, Orange, CA 92868, USA.
    The prevalence of aortic root dilatation (ARD) in mucopolysaccharidosis (MPS) is not well documented. We investigated aortic root measurements in 34 MPS patients at the Children's Hospital of Orange County (CHOC). The diagnosis, treatment status, age, gender, height, weight and aortic root parameters (aortic valve annulus (AVA), sinuses of Valsalva (SoV), and sinotubular junction (STJ)) were extracted by retrospective chart review and echocardiographic measurements. Read More

    Interactive In-Vitro Training In Physics Of Radiofrequency Ablation For Physicians And Medical Engineering Students.
    J Atr Fibrillation 2016 Jun-Jul;9(1):1403. Epub 2016 Jun 30.
    Peter Osypka Institute for Pacing and Ablation at Offenburg University of Applied Sciences.
    Radiofrequency (RF) ablation requires a complex set of devices as well as profound electrophysiological experience and substantial knowledge of physical science basics. To establish RF ablation in-vitro teaching-system, six workstations were equipped with computer-controlled RF ablation generators. Universal connection boxes allow ablation-essays with catheters of different make and model. Read More

    Low-Pressure Pericardial Tamponade: Case Report and Review of the Literature.
    J Emerg Med 2016 Nov 21. Epub 2016 Nov 21.
    Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.
    Background: Focused cardiac ultrasound (FoCUS) is accurate for determining the presence of a pericardial effusion. Using FoCUS to evaluate for pericardial tamponade, however, is more involved. Many experts teach that tamponade is unlikely if the inferior vena cava (IVC) shows respiratory variation and is not distended. Read More

    The Changing Face of HDL and the Best Way to Measure It.
    Clin Chem 2017 Jan 22;63(1):196-210. Epub 2016 Nov 22.
    Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
    Background: HDL cholesterol (HDL-C) is a commonly used lipid biomarker for assessing cardiovascular health. While a central focus has been placed on the role of HDL in the reverse cholesterol transport (RCT) process, our appreciation for the other cardioprotective properties of HDL continues to expand with further investigation into the structure and function of HDL and its specific subfractions. The development of novel assays is empowering the research community to assess different aspects of HDL function, which at some point may evolve into new diagnostic tests. Read More

    The preoperative use of field tests of exercise tolerance to predict postoperative outcome in intra-abdominal surgery: a systematic review.
    J Clin Anesth 2016 Dec 18;35:446-455. Epub 2016 Oct 18.
    Department of Anaesthesia and Intensive Care, St James's Hospital, Dublin, Ireland. Electronic address:
    Study Objective: To assess the ability of field tests of exercise tolerance, such as the 6-minute walk test (6MWT) and incremental shuttle walk test (ISWT), to predict postoperative outcome following intra-abdominal surgery.

    Design: A systematic review.

    Setting: A hospital-affiliated university. Read More

    Efficacy and safety of sugammadex compared to neostigmine for reversal of neuromuscular blockade: a meta-analysis of randomized controlled trials.
    J Clin Anesth 2016 Dec 4;35:1-12. Epub 2016 Aug 4.
    Department of Medicine, Anesthesiology and Intensive Care, University of Padova, Via C. Battisti, 267, 35121 Padova, Italy. Electronic address:
    Background And Objective: Sugammadex has been introduced for reversal of rocuronium (or vecuronium)-induced neuromuscular blockade (NMB). Although its efficacy has been established, data are conflicting whether it is safer than neostigmine traditionally used for reversing NMB.

    Design: Meta-analysis of data about effectiveness and safety of sugammadex compared to neostigmine for reversing NMB in adults was performed using the PRISMA methodology. Read More

    High flow nasal cannula use outside of the ICU; factors associated with failure.
    Pediatr Pulmonol 2016 Nov 21. Epub 2016 Nov 21.
    Emory University, Atlanta, Georgia.
    Objectives: High flow nasal cannula (HFNC) use is increasing in pediatrics. Few studies exist examining the safety of HFNC use outside the intensive care unit (ICU). This study aimed to characterize patient qualities associated with failure of HFNC use outside the ICU. Read More

    The Use of Recombinant Antithrombin III in Pediatric and Neonatal ECMO Patients.
    ASAIO J 2017 Jan/Feb;63(1):93-98
    From the *Department of Pediatrics, University of Louisville, Louisville, Kentucky; †Norton Children's Hospital, Louisville, Kentucky; ‡Pediatric Acute Care Associates of North Texas PLLC, Medical City Children's Hospital, Dallas, Texas; and §Kosair Charities Pediatric Clinical Research Unit, Louisville, Kentucky.
    A retrospective review of 77 pediatric and neonatal extracorporeal membranous oxygenation (ECMO) patients who received recombinant antithrombin III (ATIII) for ATIII activity greater than 80% was conducted. Anticoagulation management was per institutional protocol. An ATIII activity greater than 80% was targeted. Read More

    Effects of paraoxonase 1 gene polymorphisms on heart diseases: Systematic review and meta-analysis of 64 case-control studies.
    Medicine (Baltimore) 2016 Nov;95(44):e5298
    aJuarez Autonomous University of Tabasco, Multidisciplinary Academic Division of Jalpa de Mendez Jalpa de MendezbJuarez Autonomous University of Tabasco, Multidisciplinary Academic Division of Comalcalco, ComalcalcocJuarez Autonomous University of Tabasco, Academic Sciences Division Health, Villahermosa, TabascodYajalón General Hospital, Ministry of Health, Yajalón, ChiapaseNational Institute of Cardiology "Ignacio Chavez", Department of Molecular Biology, Mexico City, Mexico.
    Background: Associations between paraoxonase 1 (PON1) gene polymorphisms and heart diseases (HD) risk remain inconsistent. In order to obtain address this issue we performed a meta-analysis to assess the association between the L55M and Q192R polymorphisms of PON1 gene and heart diseases risk.

    Methods: Relevant studies were enrolled by searching databases systematically. Read More

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