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BMC Infect Dis 2019 Apr 16;19(1):326. Epub 2019 Apr 16.

Bacteriology Laboratory, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland.

Background: Endograft infection is a rare but extremely dangerous complication of aortic repair (25-100% of mortality). We describe here the first case of Listeria monocytogenes abdominal periaortitis associated with a vascular graft. We also discuss the differential diagnosis of periaortitis and provide a literature review of L. Read More

Global Spine J 2019 Apr 13;9(2):126-132. Epub 2018 Aug 13.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Study Design: Retrospective analysis.

Objective: The incidence of intradural extramedullary (IDEM) spinal tumors is increasing. Excisional laminectomy for removal and decompression is the standard of care, but complications associated with patient age are unreported in the literature. Read More

J Matern Fetal Neonatal Med 2019 Apr 14:1-131. Epub 2019 Apr 14.

d Neonatal Intensive Care Unit , Ca' Foncello Hospital , Treviso , Italy.

Background: Food Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE cell-mediated gastrointestinal food allergy that primarily presents in infancy, as early as the first hours of life. FPIES is often misdiagnosed as sepsis, severe gastroenteritis, abdominal surgical emergency or even metabolic, neurologic or cardiac disorders.

Methods: We report two neonatal cases of cow's milk protein (CMP)-induced FPIES masquerading as surgical diseases. Read More

Allergy 2019 Apr 6. Epub 2019 Apr 6.

National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Health Effects Laboratory, Division Morgantown, WV, USA.

Industrial sensitizing agents (allergens) in living and working environments play an important role in eliciting type I allergic disorders including asthma and allergic rhinitis. Successful management of allergic diseases necessitates identifying their specific causes (i.e. Read More

Radiologe 2019 Apr 4. Epub 2019 Apr 4.

Praxis für Endokrinologie und Nuklearmedizin, Brückenstraße 21, 69210, Heidelberg, Deutschland.

Background: Adequate intake of iodine is essential for normal thyroid function. However, sudden exposure to high amounts of iodine may cause thyroid dysfunction.

Aim: The aims of this paper are to summarize the literature on the effects of iodinated contrast medium (CM) on thyroid function, the risk to develop CM-induced hyper- and hypothyroidism, and to describe procedures for clinical practice regarding diagnosis, prevention, and treatment of CM-induced hyperthyroidism. Read More

Heart 2019 Apr 4. Epub 2019 Apr 4.

Center for the Diagnosis and Treatment of Pericardial Diseases, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Hypothyroidism is a well-known cause of pericardial effusion (with an incidence of 3%-37%) and can cause cardiac tamponade in severe cases. In this review, we present the current knowledge on the epidemiology of hypothyroid-induced pericardial diseases, the mechanism through which low thyroid hormone levels affect the pericardium, the associated clinical manifestations, diagnostic tests and management options. Hypothyroidism causes pericardial effusion through increased permeability of the epicardial vessels and decreased lymphatic drainage of albumin, resulting in accumulation of fluid in the pericardial space. Read More

Drugs Aging 2019 Apr 2. Epub 2019 Apr 2.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Parkinson's disease is a chronic neurodegenerative movement disorder affecting people mainly beyond their 50s. Geriatric patients with Parkinson's disease experience a specific profile of comorbidities. Multimorbidity and resulting polypharmacotherapy are frequent at this age. Read More

Kidney Int 2019 Mar 4. Epub 2019 Mar 4.

Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium. Electronic address:

Fluid therapy, which is provided to restore and maintain tissue perfusion, is part of routine management for almost all critically ill patients. However, because either too much or too little fluid can have a negative impact on patient outcomes, fluid administration must be titrated carefully for each patient. The "salvage, optimization, stabilization, de-escalation" (SOSD) mnemonic should be used as a general guide to fluid resuscitation, and fluid administration should be adapted according to the course of the disease. Read More

Prog Cardiovasc Dis 2019 Mar 25. Epub 2019 Mar 25.

Department of Internal Medicine, Division of Cardiology, East Tennessee State University, Johnson City, TN, USA. Electronic address:

Diabetes causes cardiomyopathy and increases the risk of heart failure independent of hypertension and coronary heart disease. This condition called "Diabetic Cardiomyopathy" (DCM) is becoming a well- known clinical entity. Recently, there has been substantial research exploring its molecular mechanisms, structural and functional changes, and possible development of therapeutic approaches for the prevention and treatment of DCM. Read More

Circ Res 2019 Mar 29. Epub 2019 Mar 29.

Cardiology, Barts Heart Centre.

Rationale: Cell based therapies are a novel potential treatment for refractory angina (RFA) and have been found to improve markers of angina. However, the effects on mortality and major adverse cardiac events (MACE) have not been definitively investigated.

Objective: To investigate the efficacy and safety of stem cell treatment compared with optimal medical treatment (OMT) for RFA by conducting an updated meta-analysis, looking at clinical outcomes. Read More

Pan Afr Med J 2018 4;31. Epub 2018 Sep 4.

Service de Gynéco-Obstétrique Monastir CMNM 5000 Monastir, Tunisia.

Intraoperative search for the sentinal node using patent blue is considered a non risk procedure. We emphasize the highly exceptional nature of this adverse effect previously observed in other disciplines using this coloring agent. We present a case of allergic reaction to patent blue in a patient who underwent left mastectomy with sentinel lymph node. Read More

J Clin Med 2019 Mar 26;8(3). Epub 2019 Mar 26.

University Côte d'Azur, CNRS, INSERM, IRCAN, Team 4, FHU OncoAge, 06001 Nice, France.

Lung cancer is one of the most lethal malignancies worldwide, mainly due to its late diagnoses. The detection of molecular markers on samples provided from routine bronchoscopy including several liquid-based cytology tests (e.g. Read More

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):2234-2243

Department of Biological Science, Universidade Estadual de Santa Cruz, Ilhéus, BA, Brazil.

Cardiovascular diseases (CVDs) have shown a high prevalence every year, presenting arterial hypertension as prime factor for their development, also driven by population growth, the aging of population and epidemiologic changes in disease. One of the main challenges in the study of CVD is the identification of reliable biomarkers that can be used in clinical practice and, in this context, microRNAs (miRNAs) have attracted much attention recently. MiRNAs are small non-coding RNAs, identified as post-transcriptional regulators of the expression of several genes both in physiologic and pathologic conditions. Read More

IEEE Rev Biomed Eng 2019 Mar 18. Epub 2019 Mar 18.

Heart failure (HF) is the most rapidly growing cardiovascular condition with an estimated prevalence of >37.7 million individuals globally. HF is associated with increased mortality and morbidity and confers a substantial burden, in terms of cost and quality of life, for the individuals and the healthcare systems, highlighting thus the need for early and accurate diagnosis of HF. Read More

Medicina (Kaunas) 2019 Mar 16;55(3). Epub 2019 Mar 16.

Department of Respiratory Medicine, Okinawa Chubu Hospital, 904-2293 Miyazato 281, Uruma City, Okinawa, Japan.

Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonia. Idiopathic pulmonary fibrosis is often seen in elderly men who smoke. A diagnosis of IPF is based on a combination of a detailed clinical history, specific physical examination, laboratory findings, pulmonary function tests, high-resolution computed tomography (HRCT) of the chest, and histopathology. Read More

EJIFCC 2019 Mar 1;30(1):7-13. Epub 2019 Mar 1.

Section of Clinical Biochemistry, University of Verona, Italy.

There is a common perception that laboratory medicine may be occasionally perceived as neglected discipline by clinicians, and that laboratory tests may be considered ordinary commodities. Although there is still debate on the real contribution of diagnostic testing in care pathways, many clinical diagnoses cannot be made without laboratory data. In support of evidence-based added value of laboratory diagnostics, this article aims to discuss the over-reaching contribution of some recent tests to the clinical decision making, and the unquestionable role they have played in revolutionizing clinical practice. Read More

JAMA Netw Open 2019 Mar 1;2(3):e190703. Epub 2019 Mar 1.

Division of Cardiology, University of Colorado School of Medicine, Aurora.

Importance: Standard tools used to diagnose pulmonary edema in acute decompensated heart failure (ADHF), including chest radiography (CXR), lack adequate sensitivity, which may delay appropriate diagnosis and treatment. Point-of-care lung ultrasonography (LUS) may be more accurate than CXR, but no meta-analysis of studies directly comparing the 2 tools was previously available.

Objective: To compare the accuracy of LUS with the accuracy of CXR in the diagnosis of cardiogenic pulmonary edema in adult patients presenting with dyspnea. Read More

J Am Coll Cardiol 2019 Mar;73(10):1189-1206

Cardiac Arrhythmia Center and Neurocardiology Research Center of Excellence, University of California-Los Angeles Los Angeles, California.

Autonomic nervous system control of the heart is a dynamic process in both health and disease. A multilevel neural network is responsible for control of chronotropy, lusitropy, dromotropy, and inotropy. Intrinsic autonomic dysfunction arises from diseases that directly affect the autonomic nerves, such as diabetes mellitus and the syndromes of primary autonomic failure. Read More

J Clin Med 2019 Mar 12;8(3). Epub 2019 Mar 12.

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Background And Objectives: Fluid overload and central sleep apnea are highly prevalent in patients with heart failure (HF). We performed this meta-analysis to assess the effects of acetazolamide therapy on acid/base balance and apnea indexes.

Methods: A literature search was conducted using EMBASE, MEDLINE, and Cochrane Database from inception through 18 November 2017 to identify studies evaluating the use of acetazolamide in HF. Read More

J Cardiovasc Nurs 2019 Mar 6. Epub 2019 Mar 6.

Jennifer L. Smith, PhD, RN Postdoctoral Fellow, College of Nursing, University of Kentucky, Lexington. Terry A. Lennie, PhD, RN, FAHA, FAAN Senior Associate Dean and Professor, College of Nursing, University of Kentucky, Lexington. Misook L. Chung, PhD, RN, FAHA, FAAN Professor, College of Nursing, University of Kentucky, Lexington. Gia Mudd-Martin, PhD, MPH, RN, FAHA Associate Professor, University of Kentucky, College of Nursing Lexington, Kentucky.

Background: Low-sodium diet adherence is foundational to heart failure (HF) self-management. Altered salt taste perception caused by angiotensin-converting enzyme (ACE) inhibitors commonly prescribed to patients with HF may increase sodium consumption. We hypothesized sodium intake, indicated by dietary sodium density, would be significantly higher among patients with HF prescribed ACE inhibitors compared with those not prescribed the drug. Read More

Biosens Bioelectron 2019 Apr 19;131:287-298. Epub 2019 Feb 19.

Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520-IEMN, F-59000 Lille, France. Electronic address:

Cardiovascular diseases (CVD) remain the leading cause of death within industrialized nations as well as an increasing cause of mortality and morbidity in many developing countries. Smoking, alcohol consumption and increased level of blood cholesterol are the main CVD risk factors. Other factors, such as the prevalence of overweight/obesity and diabetes, have increased considerably in recent decades and are indirect causes of CVD. Read More

J Am Board Fam Med 2019 Mar-Apr;32(2):234-247

From the Department of Epidemiology and Biostatistics, College of Public Health, (CSM, MHE, APD, YS, CCW), Department of Infectious Diseases, College of Veterinary Medicine (EH), University of Georgia, Athens, GA.

Background: A systematic review of clinical decision rules to identify patients at low risk for community-acquired pneumonia (CAP) has not been previously presented in the literature.

Methods: A systematic review of MEDLINE for prospective studies that used at least 2 signs, symptoms, or point-of-care tests to determine the likelihood of CAP. We included studies that enrolled adults and adolescents in the outpatient setting where all or a random sample of patients received a chest radiograph as the reference standard. Read More

Card Fail Rev 2019 Feb;5(1):24-26

Karolinska Institutet, Department of Medicine Stockholm, Sweden.

Despite advances in heart failure treatment, advanced heart failure affects 5-10% of people with the condition and is associated with poor prognosis. Selection for heart transplantation and left ventricular assist device implantation is a rigorous and validated process performed by specialised heart failure teams. This entails comprehensive assessment of complex diagnostic tests and risk scores, and selecting patients with the optimal benefit-risk profile. Read More

Ment Health Clin 2019 Mar 1;9(2):93-99. Epub 2019 Mar 1.

Pharmacy Librarian, Marshall B. Ketchum University, MB Ketchum Memorial Library, Fullerton, California.

Introduction: Synthetic cannabinoids (SCs) are psychoactive substances that are gaining popularity for their availability and lack of detection by standardized drug tests. Although some users may perceive SCs as safer alternatives to marijuana, some SCs are more potent and result in more severe toxicities.

Methods: A search of the literature was conducted in the PubMed and SciFinder databases. Read More

BMC Nephrol 2019 Mar 6;20(1):84. Epub 2019 Mar 6.

Department of Renal Medicine, Royal Berkshire Hospital, Royal Berkshire NHS Foundation Trust, Reading, UK.

Background: ANCA-associated vasculitis is a life-threatening, systemic autoimmune disease. There is an increased risk of organ infarction but in many cases this is asymptomatic. We described here the first reported case of PR3 vasculitis presenting with symptomatic bilateral renal wedge infarction. Read More

Front Physiol 2019 19;10:103. Epub 2019 Feb 19.

Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, China.

with Brugada syndrome (BrS) is not commonly considered as an independent risk marker for subsequent cardiac events. However, the risk of combined with other clinical characteristics has not been fully investigated. The aim of this study is to investigate and evaluate risk stratification and related risk factors of in BrS. Read More

Eur Heart J Suppl 2019 Feb 26;21(Suppl A):A2-A5. Epub 2019 Feb 26.

Institute of Clinical Medicine, Copenhagen University, Blegdamsvej 3B, Copenhagen, Denmark.

Determination of potassium level is one of the most frequent laboratory tests in clinical medicine. Hyperkalaemia is defined as a potassium level >5.0 mmol/L and is one of the most clinically important electrolyte abnormalities, because it may cause dangerous cardiac arrhythmia and sudden cardiac death. Read More

Cardiol Res 2019 Feb 24;10(1):1-8. Epub 2019 Feb 24.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital/Harvard Medical School, 75 Francis Street, CWN-L1, Boston, MA 02115, USA.

Background: The role of anesthesiologists has expanded from operating rooms to preoperative evaluation clinics. This role involves performing preoperative cardiovascular evaluation and optimization of patients before elective surgery, which can include ordering cardiac stress tests. We aimed to study the ordering patterns by anesthesiologists for preoperative cardiac stress tests, focusing on whether societal and institutional guidelines and recommendations were used. Read More

Cardiovasc Revasc Med 2019 Feb 10. Epub 2019 Feb 10.

Unique Medical Centre, Kowloon, Hong Kong.

Background: The Magmaris bioresorbable magnesium scaffold was successfully tested in in-vitro and in clinical premarket studies. Subsequently the Magmaris postmarket program aimed to review intraprocedural data of at least 2000 patients to assess user preferences, guideline adherence and intraprocedural performance in clinical routine.

Methods: This international multicentre survey encompasses data from 356 hospitals across 45 countries. Read More

Resuscitation 2019 Feb 27;138:20-27. Epub 2019 Feb 27.

University of Colorado School of Medicine, Department of Emergency Medicine, Campus Box B-215, 1240 E. 17th Avenue, Aurora, CO 80045, United States.

Introduction: Survival from traumatic cardiopulmonary arrest (TCA) has been reported at a rate as low as 0-2.6% in the civilian pre-hospital setting, and many consider resuscitation of this group to be futile. The aim of this investigation was to describe patients who received cardiac massage during TCA in a battlefield setting; we also aimed to identify predictors of survival. Read More

Sports Med 2019 Apr;49(4):587-600

PROFITH "PROmoting FITness and Health through physical activity" Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Background: Cardiorespiratory fitness (CRF) assessment provides key information regarding general health status that has high clinical utility. In addition, in the sports setting, CRF testing is needed to establish a baseline level, prescribe an individualized training program and monitor improvement in athletic performance. As such, the assessment of CRF has both clinical and sports utility. Read More

Breast 2019 Jan 8;45:29-35. Epub 2019 Jan 8.

Department of Genetics, Institut Curie, Paris, France; Paris Descartes Sorbonne-Paris-Cité University, Paris, France; INSERM U830, Institut Curie Paris, Paris, France. Electronic address:

Multigene panel testing for breast and ovarian cancer predisposition diagnosis is a useful tool as it makes possible to sequence a considerable number of genes in a large number of individuals. More than 200 different multigene panels in which the two major BRCA1 and BRCA2 breast cancer predisposing genes are included are proposed by public or commercial laboratories. We review the clinical validity and clinical utility of the 26 genes most oftenly included in these panels. Read More

Eur Heart J 2019 Feb 27. Epub 2019 Feb 27.

Department of Cardiology, Icahn School of Medicine at Mount Sinai, Mount Sinai Saint Luke's Medical Center, 1111 Amsterdam Ave, New York, NY, USA.

The 2016 National Institute of Health and Care Excellence clinical guideline for the assessment and diagnosis of chest pain positions coronary computed tomography angiography as the first test for all stable chest pain patients without confirmed coronary artery disease and discards the previous emphasis on calculation of pre-test likelihood recommended in their 2012 edition of the guidelines. On the other hand, the American College of Cardiology Foundation/American Heart Association and the European Society of Cardiology guidelines continue to present the stress testing functional modalities as the tests of choice. The aim of this review is to present, in the form of a debate, the pros and cons of these paradigm changing recommendations, with an emphasis on literature review and projection of future needs, with conclusions to be drawn by the reader. Read More

Curr Diabetes Rev 2019 Feb 26. Epub 2019 Feb 26.

Faculty of Medicine, Alexandria University. Egypt.

Diabetic polyneuropathy (DPN) is a complex and multifactorial entity in which various factors besides hyperglycemia play an important role. Symptoms of DPN are sensory, motor or autonomic. Intensive research proved that oxidative stress is the common denominator for the four major destructive pathways of hyperglycemia including increased hexosamine pathway flux, activation of Protein kinase-C (PKC) pathway, increased Advanced Glycated End-products (AGEs) formation, and increased Polyol Pathway flux. Read More

Braz J Cardiovasc Surg 2019 Jan-Feb;34(1):76-84

Department of Cardiology, The First Hospital of Putian, Teaching Hospital, Fujian Medical University, Putian, Fujian Province, People's Republic of China.

Postoperative cognitive dysfunction is a common complication following cardiac surgery. The incidence of cognitive dysfunction is more pronounced in patients receiving a cardiac operation than in those undergoing a non-cardiac operation. Clinical observations demonstrated that pulsatile flow was superior to nonpulsatile flow, and membrane oxygenator was superior to bubble oxygenator in terms of postoperative cognitive status. Read More

Braz J Cardiovasc Surg 2019 Jan-Feb;34(1):28-32

Cardiac Surgery Department, King Abdullah Medical City, Makkah, Kingdom of Saudi Arabia.

Objective: The diabetic population has a high prevalence of coronary artery disease, and frequently patients with diabetes undergo coronary artery bypass graft (CABG) surgery. Elevated glycated hemoglobin (HbA1c) in diabetics is shown to be associated with morbidity and mortality, but the association of HbA1c with postoperative length of hospital stay (LOS) has conflicting results. In this study, we aim to identify if elevated HbA1c levels are associated with prolonged LOS after CABG surgery. Read More

Front Neurol 2019 12;10:53. Epub 2019 Feb 12.

Neurological University Clinic Carl Gustav Carus, Dresden, Germany.

The autonomic nervous system as operating system of the human organism permeats all organ systems with its pathways permeating that it is involved with virtually all diseases. Anatomically a central part, an afferent part and sympathetic and parasympathetic efferent system can be distinguished. Among the different functional subsystems of the autonomic nervous system, the cardiovascular autonomic nervous system is most frequently examined with easily recordable cardiovascular biosignals as heart rate and blood pressure. Read More

Crit Care Nurs Q 2019 Apr/Jun;42(2):208-214

Sciamanda Total Health and Wellness, Erie, Pennsylvania (Dr DuCharme); Robert Morris University, Moon Township, Pennsylvania (Ms Macci Bires); and Emergency Department, Saint Vincent Hospital, Erie, Pennsylvania (Drs Montanye, Khan, DuCharme, and Carlson and Mr Linse).

This article provides research of cardiac biomarkers being drawn in the prehospital setting compared with the emergency department (ED) on intervals critical to the diagnosis of acute myocardial infarction. This is a retrospective chart review of patients brought to the ED of a single, urban teaching hospital by a single emergency medical service (EMS) agency with a chief complaint of "chest pain." We abstracted specific patient characteristics, intervals, positive troponin values, and rates of hemolysis from hospital records utilizing a custom data abstraction tool designed for this study through consensus of the authors. Read More

Seizure 2019 Mar 15;66:53-60. Epub 2019 Feb 15.

Department of Neurology, West China Hospital, Sichuan University, Wai Nan Guo Xue Lane 37 #, Chengdu 610041, Sichuan, China. Electronic address:

Purpose: To evaluate the predictors of seizure reduction outcome after vagus nerve stimulation (VNS) in patients with drug-resistant epilepsy (DRE).

Methods: A meta-analysis was performed using relevant research from databases such as PubMed, Embase, Cochrane Online Library, and Clinicaltrials.gov. Read More

F1000Res 2018 19;7:204. Epub 2018 Feb 19.

P.N. Lee Statistics and Computing Ltd., Sutton, SM2 5DA, UK.

 To present up-to-date meta-analyses of evidence from Japan relating smoking to major smoking-related diseases.   We restricted attention to lung cancer, chronic obstructive pulmonary disease (COPD), ischemic heart disease (IHD) and stroke, considering relative risks (RRs) for current and ex-smokers relative to never smokers.  Evidence by amount smoked and time quit was also considered. Read More

BMC Anesthesiol 2019 Feb 23;19(1):25. Epub 2019 Feb 23.

Department of Anesthesia, Toronto Western Hospital, University Health Network, 2-434 McLaughlin Wing, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada.

Background: Post-operative delirium (POD) is a common post-operative complication in elderly individuals and imposes a significant health and financial burden. Identifying predictive biomarkers may help understand the pathophysiology of POD. Our objective is to summarize the evidence of pre-operative biomarkers and imaging tests to predict POD in patients undergoing non-cardiac surgery. Read More

Diabetes Metab J 2019 Feb;43(1):3-30

Division of Endocrinology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Read More

Ther Hypothermia Temp Manag 2019 Feb 21. Epub 2019 Feb 21.

1 Lehigh Valley Health Network, OACIS/Palliative Medicine, Allentown, Pennsylvania.

Few studies have been done assessing the impact of palliative care on patients suffering cardiac arrest and requiring therapeutic hypothermia (TH). We conducted a retrospective cohort study to compare resource utilization and quality indicators among patients undergoing TH with and without palliative care consultation. Data were collected, over a two-year period, from the institutional international cardiac arrest registry database and electronic medical record review. Read More

Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):266-272

HOUSTON METHODIST HOSPITAL, HOUSTON, TEXAS.

Coronary artery disease (CAD) is the leading cause of morbidity and mortality in patients with diabetes mellitus. Patients with diabetes have a higher prevalence of CAD and a larger magnitude of ischemia, and they are more likely to have silent myocardial ischemia and myocardial infarction. However, recent large cohort studies demonstrate that diabetic patients are not a homogenous group with similar high risk for cardiac events. Read More

Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):257-265

HOUSTON METHODIST HOSPITAL, HOUSTON, TEXAS.

Type 2 diabetes negatively impacts heart failure outcomes. Insulin resistance, central adiposity, dyslipidemia, and altered cellular substrate metabolism each have a mechanistic role. Management strategies focused solely on glycemic control have had limited success. Read More