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    Multiple myeloma masquerading as diabetic macular oedema.
    BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.
    LV Prasad Eye Institute, Hyderabad, India.
    A 58-year-old man, a known diabetic and hypertensive for 5 years was presented to us with a drop in reading vision in both eyes of 2 months duration. His best-corrected visual acuity was 6/24, N36 in both eyes. Fundus findings revealed moderate non-proliferative diabetic retinopathy with bilateral diffuse macular oedema. Read More
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    Quantitative evaluation of OCT angiography images of diabetic retinopathy eyes before and after removal of projection artifacts.
    J Biophotonics 2018 Apr 16:e201800003. Epub 2018 Apr 16.
    Imaging, Biomechanics and Mathematical Modeling Solutions, Narayana Nethralaya Foundation, Bangalore, India.
    Projection artifacts (PA) affect the quantification of vascular parameters in the deep layer OCT angiography image. This study eliminated PA and quantified its effect on imaging. 53 eyes (30 subjects) of normal Indian subjects and 113 eyes (92 patients) of type 2 diabetes mellitus with retinopathy (DR) underwent imaging with a scan area of 3 mm × 3 mm. Read More
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    Uric acid is not associated with diabetic nephropathy and other complications in type 1 diabetes.
    Nephrol Dial Transplant 2018 Apr 11. Epub 2018 Apr 11.
    Steno Diabetes Center Copenhagen, Gentofte, Denmark.
    Background: To examine the association between plasma uric acid (UA) and the presence of diabetic complications including diabetic nephropathy and cardiovascular risk factors in patients with type 1 diabetes.

    Methods: This study, which is cross-sectional in design, included 676 Caucasian type 1 diabetes patients from the Steno Diabetes Center Copenhagen. Participants with UA within the three lowest sex-specific quartiles were compared with participants with levels in the highest quartile. Read More
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    Inhibition of miR-21-5p suppresses high glucose-induced proliferation and angiogenesis of human retinal microvascular endothelial cells by the regulation of AKT and ERK pathways via maspin.
    Biosci Biotechnol Biochem 2018 Apr 15:1-11. Epub 2018 Apr 15.
    a Department of Ophthalmology , The First Affiliated Hospital of China Medical University , Shenyang , People's Republic of China.
    The aim of the present study is to investigate the role of miR-21-5p in angiogenesis of human retinal microvascular endothelial cells (HRMECs). HRMECs were incubated with 5 mM glucose, 30 mM glucose or 30 mM mannitol for 24 h, 48 h or 72 h. Then, HRMECs exposed to 30 mM glucose were transfected with miR-21-5p inhibitor. Read More
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    Resistive index of ophthalmic artery correlates with retinal pigment epithelial alterations on spectral domain optical coherence tomography in diabetic retinopathy.
    Int J Retina Vitreous 2018 9;4:12. Epub 2018 Apr 9.
    Department of Ophthalmology, Pallas Klinik, Aarau, Switzerland.
    Background: Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapillaries. RPE topographic alterations have been observed to be associated with severity of retinopathy. Read More
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    Alteration of layer thickness in the choroid of diabetic patients.
    Clin Exp Ophthalmol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.
    Importance: Choroidal thickness changes in diabetic retinopathy improve understanding the pathophysiology and managements of this disease.

    Background: To examine the choroidal layer thickness in diabetes mellitus (DM) patients and normal individuals, and to compare the findings based on medical history of systemic DM treatments, and stage of diabetic retinopathy (DR).

    Design: Case control study. Read More
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    Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis via regulating miR-2113/RP11-982M15.8/Zeb1 pathway.
    Biochem Biophys Res Commun 2018 Apr 11. Epub 2018 Apr 11.
    Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Electronic address:
    Recent study has showed that Ginsenoside Rg1, the mian active compound of Panax ginseng, could ameliorate oxidative stress and myocardial apoptosis in diabetes mellitus. However, the roles and mechanisms of Rg1 in proliferative diabetic retinopathy (PDR) are still unclear. In the present study, we aimed to investigate the effects of Rg1 on mesenchymal activation of high-glucose (HG) cultured müller cells. Read More
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    The Correlation between Changes in Biochemical Parameters and Central Macular Thickness in Patients with Non-Proliferative Diabetic Retinopathy.
    Med Hypothesis Discov Innov Ophthalmol 2018 ;7(1):10-16
    Associate Professor, University of Health Sciences, Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.
    This study aimed at evaluating the correlation between changes in Hemoglobin A1c (HbA1c) and fasting serum lipids, and Central Macular Thickness (CMT) in patients with Non-Proliferative Diabetic Retinopathy (NPDR). In the current research, both eyes of 68 patients with mild or moderate NPDR, without clinically significant macular edema, were studied. Levels of fasting serum lipids, HbAlc, and CMT were measured during the first visit and at the end of the follow-up period (3 months). Read More
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    Optical Coherence Tomography Angiography of Foveal Neovascularization in Diabetic Retinopathy.
    Case Rep Ophthalmol 2018 Jan-Apr;9(1):87-91. Epub 2018 Jan 29.
    1st Department of Ophthalmology, University of Athens, Georgios Gennimatas General Hospital, Athens, Greece.
    Purpose: To report a case of foveal neovascularization in a patient with proliferative diabetic retinopathy as seen on optical coherence tomography angiography (OCT-A).

    Methods: Multimodal imaging was used for diagnostic investigation.

    Patient: A 61-year-old male with a 16-year history of insulin-dependent diabetes mellitus was referred to our medical retina department for examination and management. Read More
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    Clinical Efficacy and Safety of the EX-PRESS Filtration Device in Patients with Advanced Neovascular Glaucoma and Proliferative Diabetic Retinopathy.
    Case Rep Ophthalmol 2018 Jan-Apr;9(1):61-69. Epub 2018 Jan 23.
    Department of Ophthalmology, Rabin Medical Center, Beilinson Hospital, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: The prognosis of conventional filtration surgery in eyes with neovascular glaucoma (NVG) is limited due to increased fibrovascular proliferation or bleeding. This study aims to evaluate the safety and efficacy of the EX-PRESS filtration device in the management of NVG associated with proliferative diabetic retinopathy (PDR).

    Methods: In this retrospective case series, we reviewed the medical records of patients diagnosed as having NVG associated with PDR who underwent EX-PRESS filtration surgery. Read More
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    Prevalence of diabetic retinopathy among self-reported adult diabetics in districts of Eastern Nepal in a community based study.
    Nepal J Ophthalmol 2017 Jul;9(18):136-142
    Introduction: Diabetic retinopathy (DR) is the leading cause of blindness among working age adults around the world. Each year more and more people live with this condition, which can result in life-changing complications.

    Objective: To determine the prevalence and risk factors of diabetic retinopathy (DR) in a large community based screening programme, in order to estimate the future burden of the disease. Read More
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    Venous beading in two or more quadrants might not be a sensitive grading criterion for severe nonproliferative diabetic retinopathy.
    Graefes Arch Clin Exp Ophthalmol 2018 Apr 6. Epub 2018 Apr 6.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
    Purpose: To determine whether venous beading (VB) in two or more quadrants is an appropriate grading criterion for severe nonproliferative diabetic retinopathy (NPDR).

    Methods: A hospital-based, retrospective, cross-sectional study. A total of 806 patients admitted with diabetic retinopathy (DR) from January 2014 to April 2017 were included in this study. Read More
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    The ROCK pathway inhibitor Y-27632 mitigates hypoxia and oxidative stress-induced injury to retinal Müller cells.
    Neural Regen Res 2018 Mar;13(3):549-555
    Department of Ophthalmology, Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an, Shaanxi Province, China.
    Rho kinase (ROCK) was the first downstream Rho effector found to mediate RhoA-induced actin cytoskeletal changes through effects on myosin light chain phosphorylation. There is abundant evidence that the ROCK pathway participates in the pathogenesis of retinal endothelial injury and proliferative epiretinal membrane traction. In this study, we investigated the effect of the ROCK pathway inhibitor Y-27632 on retinal Müller cells subjected to hypoxia or oxidative stress. Read More
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    Angiopoietin-like 3 is a Potential Biomarker for Retinopathy in Type 2 Diabetic Patients.
    Am J Ophthalmol 2018 Apr 2. Epub 2018 Apr 2.
    Beijing Key Laboratory of Diabetes Prevention and Research, Department of Endocrinology, Lu He hospital, Capital Medical University, Beijing 101149, China. Electronic address:
    Purpose: To investigate whether angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are differentially associated with the severity of retinopathy in patients with type 2 diabetes mellitus (T2DM).

    Design: Cross-sectional study.

    Methods: Serum levels of ANGPTL3, ANGPTL4, high-sensitivity C-reactive protein (CRP), vascular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) were quantified by ELISA. Read More
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    Pupillary Abnormalities with Varying Severity of Diabetic Retinopathy.
    Sci Rep 2018 Apr 4;8(1):5636. Epub 2018 Apr 4.
    Shri Bhagwan Mahavir Vitreoretinal services, 18, College Road, Sankara Nethralaya, Chennai, 600 006, Tamil Nadu, India.
    Our aim is to study the dynamics of pupillary abnormalities in varying severity of diabetic retinopathy. A non-interventional case-control study with 405 eyes of 244 subjects with diabetes, and 41 eyes of 26 subjects with no history of diabetes was done. Diabetes group was classified according to retinopathy severity: no retinopathy, mild non-proliferative diabetic retinopathy (NPDR), moderate NPDR, severe NPDR and proliferative diabetic retinopathy (PDR). Read More
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    Cost Evaluation of Early Vitrectomy versus Panretinal Photocoagulation and Intravitreal Ranibizumab for Proliferative Diabetic Retinopathy.
    Ophthalmology 2018 Mar 29. Epub 2018 Mar 29.
    Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida. Electronic address:
    Purpose: To evaluate costs and cost-utility of early vitrectomy (pars plana vitrectomy [PPV]) compared with panretinal photocoagulation (PRP) and intravitreal ranibizumab (IVR) for proliferative diabetic retinopathy (PDR) without diabetic macular edema.

    Design: A decision analysis model of cost-utility.

    Participants: There were no participants. Read More
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    Loss to Follow-Up in Patients with Proliferative Diabetic Retinopathy after Panretinal Photocoagulation or Intravitreal Anti-VEGF Injections.
    Ophthalmology 2018 Mar 29. Epub 2018 Mar 29.
    The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania. Electronic address:
    Purpose: Loss to follow-up (LTFU) may contribute to vision loss in patients with active proliferative diabetic retinopathy (PDR). The aim of this study is to determine and compare the rates of LTFU in patients with PDR receiving panretinal photocoagulation (PRP) or intravitreal injections (IVIs) with anti-vascular endothelial growth factor (VEGF) over approximately 4 years. Moreover, this study evaluates various risk factors for LTFU. Read More
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    Regional differences in the prevalence of diabetic retinopathy: a multi center study in Brazil.
    Diabetol Metab Syndr 2018 14;10:17. Epub 2018 Mar 14.
    1Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro, 77, Vila Isabel, Rio de Janeiro, RJ Zip Code: 20551-030 Brazil.
    Background: Diabetic retinopathy has a significant impact in every healthcare system. Despite that fact, there are few accurate estimates in the prevalence of DR in Brazil's different geographic regions, particularly proliferative DR and diabetic macular edema. This study aims to determine the prevalence of diabetic retinopathy in Brazil's five continental regions and its determinant factors. Read More
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    Diabetic retinopathy in patients with diabetic foot syndrome in South India.
    Indian J Ophthalmol 2018 Apr;66(4):547-550
    Department of Ophthalmology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
    Purpose: The purpose was to study the retinopathy status in diabetic patients with a risk of diabetic foot (DF) syndrome visiting a tertiary care hospital in South India.

    Methods: In this cross sectional study all patients with diabetes mellitus (DM) with a risk of DF syndrome, visiting a tertiary care hospital during the study period, underwent an ophthalmological evaluation for documentation of their retinopathy status.

    Results: One hundred and eighty-two patients diagnosed to have a risk profile for DF syndrome were included in the study. Read More
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    Prevalence, progression, and outcomes of diabetic retinopathy during pregnancy in Indian scenario.
    Indian J Ophthalmol 2018 Apr;66(4):541-546
    Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
    Purpose: The objective of this study is to evaluate pattern of diabetic retinopathy (DR) during pregnancy in females with pregestational diabetes mellitus (DM).

    Methods: This is an ambispective observational cohort study conducted at an Indian tertiary care centre. A total of 50 pregnant females with pregestational DM were included while those with gestational DM were excluded from the study. Read More
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    (Pro)renin receptor: Involvement in diabetic retinopathy and development of molecular targeted therapy.
    J Diabetes Investig 2018 Mar 25. Epub 2018 Mar 25.
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.
    The renin-angiotensin system (RAS), a crucial regulator of systemic blood pressure (circulatory RAS), plays distinct roles in pathological angiogenesis and inflammation in various organs (tissue RAS) such as diabetic microvascular complications. Using ocular clinical samples and animal disease models, we elucidated molecular mechanisms in which tissue RAS excites the expression of vascular endothelial growth factor (VEGF)-A responsible for retinal inflammation and angiogenesis, the two major pathological events in diabetic retinopathy (DR). Furthermore, we revealed the involvement of (pro)renin receptor [(P)RR] in retinal RAS activation and its concurrent intracellular signal transduction [e. Read More
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    Impact of Incidence and Progression of Diabetic Retinopathy on Vision-Specific Functioning.
    Ophthalmology 2018 Mar 20. Epub 2018 Mar 20.
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Duke-NUS Medical School, Office of Clinical Sciences, Singapore. Electronic address:
    Purpose: To investigate the independent impact of the incidence and progression of diabetic retinopathy (DR) on visual functioning (VF).

    Design: Population-based cohort study.

    Participants: A total of 518 participants aged 40 to 80 years (baseline visit 2007-2009 and second visit 6 years later, 2013-2015), with diabetes, clinical data, and VF information at both visits. Read More
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    Association Between Self-reported Physical Activity and Skin Autofluorescence, a Marker of Tissue Accumulation of Advanced Glycation End Products in Adults With Type 1 Diabetes: A Cross-sectional Study.
    Clin Ther 2018 Mar 19. Epub 2018 Mar 19.
    Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.
    Purpose: The accumulation of advanced glycation end products (AGEs) in local tissue is an important cause of low-grade inflammation and oxidative stress and is linked to late diabetic complications. Physical activity has various beneficial cardiometabolic effects in type 1 diabetes (T1D) and is associated with lower frequency of chronic complications of diabetes, although the specific mechanisms still remain unclear. The present study determines the association between self-reported physical activity and skin autofluorescence (AF), a marker of tissue accumulation of AGEs in adults with T1D. Read More
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    Clinical features of patients with diabetic anterior uveitis.
    Br J Ophthalmol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan.
    Aim: To describe clinical features and outcomes of new-onset anterior uveitis associated with poorly controlled or undiagnosed diabetes mellitus.

    Methods: Retrospective analysis of 25 eyes of 18 patients (14 men, 4 women; mean age 44 years) who presented between December 2001 and October 2016 to the Kyorin Eye Center.

    Results: Ocular findings at presentation included posterior synechiae (15 eyes, 60%), anterior chamber fibrin (13 eyes, 52%), keratic precipitates (10 eyes, 40%), Descemet membrane folds (7 eyes, 28%) and hypopyon (3 eyes, 12%). Read More
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    Individuals' Perspectives on Coping with Vision Loss from Diabetic Retinopathy.
    Optom Vis Sci 2018 Apr;95(4):362-372
    Centre for Eye Research Australia, University of Melbourne, Australia, Royal Victorian Eye and Ear Hospital.
    Significance: People with vision loss from diabetic retinopathy (DR) and diabetic macular edema (DME) use problem-focused and emotion-regulation strategies that may influence their short- and longer-term adaptation and psychological outcomes. Our findings can assist the development of models of adjustment to DR/DME-related vision loss and treatments focused on adaptation.

    Purpose: To qualitatively determine the coping strategies used by participants with vision loss resulting from DR/DME. Read More
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    Procoagulant Activity of Blood and Endothelial Cells via Phosphatidylserine Exposure and Microparticle Delivery in Patients with Diabetic Retinopathy.
    Cell Physiol Biochem 2018 Mar 15;45(6):2411-2420. Epub 2018 Mar 15.
    Department of Hematology, First Affiliated Hospital, Harbin Medical University, Harbin, China.
    Background/aims: The mechanisms for thrombosis in diabetic retinopathy (DR) are complex and need to be further elucidated. The purpose of this study was to test phosphatidylserine (PS) exposure on microparticles (MPs) and MP-origin cells from the circulation and to analyze cell-/MP-associated procoagulant activity (PCA) in DR patients.

    Methods: PS-positive MPs and cells from healthy controls (n = 20) and diabetic patients (n = 60) were analyzed by flow cytometry and confocal microscopy. Read More
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    ASYMMETRIC DIABETIC RETINOPATHY PROGRESSION IN PATIENTS WITH AXIAL ANISOMETROPIA.
    Retina 2018 Mar 15. Epub 2018 Mar 15.
    Department of Ophthalmology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
    Purpose: To investigate the differences in the progression of diabetic retinopathy (DR) in both eyes of patients with axial anisometropia.

    Methods: A retrospective review was conducted on diabetic patients who had different axial lengths (difference greater than 1 mm) in each eye. The primary objective of this study was to analyze the differences in the progression of DR in both eyes of patients with axial anisometropia. Read More
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    Different lasers and techniques for proliferative diabetic retinopathy.
    Cochrane Database Syst Rev 2018 03 15;3:CD012314. Epub 2018 Mar 15.
    Ophthalmology Department, Royal Victoria Hospital, Grosvenor Road, Belfast, UK, BT12 6BA.
    Background: Diabetic retinopathy (DR) is a chronic progressive disease of the retinal microvasculature associated with prolonged hyperglycaemia. Proliferative DR (PDR) is a sight-threatening complication of DR and is characterised by the development of abnormal new vessels in the retina, optic nerve head or anterior segment of the eye. Argon laser photocoagulation has been the gold standard for the treatment of PDR for many years, using regimens evaluated by the Early Treatment of Diabetic Retinopathy Study (ETDRS). Read More
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    [Effect of internal limiting membrane peeling on morpho-functional state of the retina in patients with proliferative diabetic retinopathy (preliminary report)].
    Vestn Oftalmol 2018 ;134(1):63-69
    Ufa Eye Research Institute, 90 Pushkin St., Ufa, Republic of Bashkortostan, Russian Federation, 450008.
    Purpose: To compare morpho-functional parameters of retina during vitrectomy with and without internal limiting membrane (ILM) peeling in patients with proliferative diabetic retinopathy.

    Material And Methods: The study included 55 patients (55 eyes) that had underwent vitreoretinal surgery in the setting of antivasoproliferative therapy for proliferative diabetic retinopathy. Patients of the 1 group (n=27) underwent vitrectomy with silicone tamponade, 2 group (n=28) received similar treatment with the addition of ILM peeling. Read More
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    Electroretinogram evaluation for the treatment of proliferative diabetic retinopathy by short-pulse pattern scanning laser panretinal photocoagulation.
    Lasers Med Sci 2018 Mar 15. Epub 2018 Mar 15.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No. 54 South Xianlie Road, Guangzhou, Guangdong, 510060, China.
    Panretinal photocoagulation (PRP) is a standard method for proliferative diabetic retinopathy (PDR) treatment. However, conventional PRP usually significantly damages the retinal structure and vision. Retinal pattern scanning laser (PASCAL) photocoagulation has emerged as a new technique with fewer complications for the treatment of retinal disorders. Read More
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    Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis.
    Clin Proteomics 2018 9;15:12. Epub 2018 Mar 9.
    1Department of Ophthalmology, Shanghai General Hospital, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai Engineering Center for Visual Science and Photomedicine, No. 100 Haining Road, Shanghai, 200080 China.
    Background: Preoperative treatment of anti-vascular endothelial growth factor (VEGF) agents is extensively used in proliferative diabetic retinopathy (PDR), but the molecular mechanism is not fully understood. The objective of this research is to observe change of protein profile induced by ranibizumab (an anti-VEGF agent) in vitreous humor from PDR patients and reveal the effects of anti-VEGF treatment on PDR.

    Methods: A proteomic method was used to identify differentially expressed proteins in vitreous humor. Read More
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    The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization.
    J Pathol 2018 Mar 13. Epub 2018 Mar 13.
    Research Programmes Unit, Genome-Scale Biology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
    Proliferative diabetic retinopathy (PDR) is a major diabetic microvascular complication characterized by pathological angiogenesis. Several retinopathy animal models have been developed to study the disease mechanisms and putative targets. However, knowledge on the human proliferative disease remains incomplete, relying on steady-state results from thin histological neovascular tissue sections and vitreous samples. Read More
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    Diabetic Retinopathy Awareness and Associations with Multiple Comorbidities: Insights from DIAMOND Study.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):30-35
    Chairman and Medical Director, Aditya Jyot Eye Hospital Pvt. Ltd., Mumbai, Maharashtra, India.
    Background: Diabetic retinopathy (DR) is leading cause of visual impairment in working-age adults. Macular edema can occur with or without other signs of retinopathy.

    Methods: This was a single-center, retrospective study conducted over 2 years in patients (>40 years of age) having type 2 diabetes mellitus (T2DM). Read More
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    Thin Rigid Contact Lens Used in Vitreous-Retinal Surgery for Corneal Protection: A Randomized Controlled Trial.
    Eye Contact Lens 2018 Mar 12. Epub 2018 Mar 12.
    Department of Ophthalmology (Z.H., Y.D., X.Z., S.Y., J.L., P.X., and Q.L.), The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Department of Ophthalmology (Y.D.), Zhongda Hospital Southeast University, Nanjing, China; and Department of Ophthalmology (X.Z.), Wuxi Children's Hospital, Wuxi, China.
    Purpose: To design a rigid contact lens (CL) to be used in combination with a wide-angle viewing system and analyze its protection for corneal epithelial during vitreous-retinal surgery.

    Methods: A thin and lightweight rigid CL was designed and constructed. The impact of the CL on the visualized fundus range was evaluated using a concrete eye model. Read More
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    Feasibility and patient acceptability of a novel artificial intelligence-based screening model for diabetic retinopathy at endocrinology outpatient services: a pilot study.
    Sci Rep 2018 Mar 12;8(1):4330. Epub 2018 Mar 12.
    Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, Melbourne, Australia.
    The purpose of this study is to evaluate the feasibility and patient acceptability of a novel artificial intelligence (AI)-based diabetic retinopathy (DR) screening model within endocrinology outpatient settings. Adults with diabetes were recruited from two urban endocrinology outpatient clinics and single-field, non-mydriatic fundus photographs were taken and graded for referable DR ( ≥ pre-proliferative DR). Each participant underwent; (1) automated screening model; where a deep learning algorithm (DLA) provided real-time reporting of results; and (2) manual model where retinal images were transferred to a retinal grading centre and manual grading outcomes were distributed to the patient within 2 weeks of assessment. Read More
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    Recent clinically relevant highlights from the Diabetic Retinopathy Clinical Research Network.
    Curr Opin Ophthalmol 2018 May;29(3):199-205
    Retina Division, Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland, USA.
    Purpose Of Review: To present some recent clinically relevant results from Diabetic Retinopathy Clinical Research (DRCR) Network trials that may guide management of diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR).

    Recent Findings: Among eyes with DME and visual acuity 20/50 or worse, aflibercept, on average, had greater improvement in visual acuity over 2 years compared with bevacizumab or ranibizumab. Aflibercept is associated with higher rates of improvements in diabetic retinopathy severity among eyes with PDR and vision-impairing DME at baseline compared with bevacizumab or ranibizumab. Read More
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    Automated diabetic retinopathy detection in smartphone-based fundus photography using artificial intelligence.
    Eye (Lond) 2018 Mar 9. Epub 2018 Mar 9.
    Dr. Mohan's Diabetes Specialities Centre & Madras Diabetes Research Foundation, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, IDF Centre of Excellence in Diabetes Care & ICMR Centre for Advanced Research on Diabetes, Chennai, Tamil Nadu, India.
    Objectives: To assess the role of artificial intelligence (AI)-based automated software for detection of diabetic retinopathy (DR) and sight-threatening DR (STDR) by fundus photography taken using a smartphone-based device and validate it against ophthalmologist's grading.

    Methods: Three hundred and one patients with type 2 diabetes underwent retinal photography with Remidio 'Fundus on phone' (FOP), a smartphone-based device, at a tertiary care diabetes centre in India. Grading of DR was performed by the ophthalmologists using International Clinical DR (ICDR) classification scale. Read More
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    Association of serum vitamin D levels and diabetic retinopathy in Asian Indians with type 2 diabetes.
    Diabetes Res Clin Pract 2018 Mar 5;139:308-313. Epub 2018 Mar 5.
    Emory University School of Medicine, Atlanta, GA, United States. Electronic address:
    Background: Vitamin D deficiency (VDD) is a condition that has been associated with diabetic retinopathy (DR) in various populations, but has not been studied in Asian Indians.

    Aims: To evaluate the association of serum 25-hydroxyvitamin D (25(OH)D) levels with presence and severity of DR among Asian Indians with type 2 diabetes.

    Methods: We collected information on individuals with type 2 diabetes that received care at a tertiary diabetes centre in India, between 2012 and 2015. Read More
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    Anatomical results and complications after silicone oil removal.
    Rom J Ophthalmol 2017 Oct-Dec;61(4):261-266
    Ophthalmology Clinic, "Sf. Spiridon" Clinical Emergency Hospital, Iasi, Romania.
    of the report was to evaluate anatomical results and intra and postoperative complications after silicone oil (SIO) removal.

    Methods: Retrospective, interventional study evaluating consecutive cases with ambulatory SIO removal after vitrectomy for complex retinal detachments. The anatomical result was the main followed parameter. Read More
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    Observation of optic disc neovascularization using OCT angiography in proliferative diabetic retinopathy after intravitreal conbercept injections.
    Sci Rep 2018 Mar 5;8(1):3972. Epub 2018 Mar 5.
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
    This study reports the short-term efficacy and safety of intravitreal conbercept injections for neovascularization at the disc (NVD) in patients with proliferative diabetic retinopathy (PDR). Conbercept is a recombinant fusion protein with a high affinity for all isoforms of vascular endothelial growth factor (VEGF)-A, placental growth factor and VEGF-B. A prospective case series study was conducted in 15 patients (15 eyes). Read More
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    Correlation of retinal neurodegeneration with measures of peripheral autonomic neuropathy in type 1 diabetes.
    Acta Ophthalmol 2018 Mar 5. Epub 2018 Mar 5.
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
    Purpose: To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR).

    Methods: Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation. Read More
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    Prevalence of diabetic retinopathy and visual impairment in patients with diabetes mellitus in Zambia through the implementation of a mobile diabetic retinopathy screening project in the Copperbelt province: a cross-sectional study.
    Eye (Lond) 2018 Mar 5. Epub 2018 Mar 5.
    Department of Ophthalmology, Frimley Park Hospital, Frimley, UK.
    Aims: A paucity of literature exists on prevalence of diabetic retinopathy (DR) in sub-Saharan Africa. We aim to estimate the prevalence of DR and visual impairment in Zambia's Copperbelt province through a cross-sectional study.

    Methods: All patients with a diagnosis of diabetes mellitus attending a DR screening programme were eligible to participate. Read More
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    Progression of diabetic retinopathy severity after treatment with dexamethasone implant: a 24-month cohort study the 'DR-Pro-DEX Study'.
    Acta Diabetol 2018 Mar 1. Epub 2018 Mar 1.
    Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
    Purpose: Intravitreal anti-vascular endothelial growth factor agents have been shown to reduce diabetic retinopathy (DR) progression; data on the effects of intravitreal corticosteroids on modifying disease severity are limited. This study evaluates the long-term effect of intravitreal dexamethasone implant (DEX) on the severity and progression of non-proliferative DR (NPDR).

    Methods: This was a retrospective cohort study. Read More
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    Fundus fluorescence Angiography in diagnosing diabetic retinopathy.
    Pak J Med Sci 2017 Nov-Dec;33(6):1328-1332
    Bin Tong, Department of Ophthalmology, Binzhou People's Hospital, Shandong, 256600, China.
    Objective: To investigate the manifestation characteristics of fundus fluorescence angiography (FFA) and its values in diagnosing diabetic retinopathy through comparing direct ophthalmoscopy.

    Methods: Two hundred fifty patients (500 eyes) who were suspected as diabetic retinopathy and admitted to the hospital between February 2015 and December 2016 were selected. They underwent direct ophthalmoscopy and FFA. Read More
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    Hybrid wide-angle viewing-endoscopic vitrectomy using a 3D visualization system.
    Clin Ophthalmol 2018 12;12:313-317. Epub 2018 Feb 12.
    Department of Ophthalmology, National Organization Kyoto Medical Center, Kyoto, Japan.
    Purpose: To introduce a hybrid wide-angle viewing-endoscopic vitrectomy, which we have reported, using a 3D visualization system developed recently.

    Subjects And Methods: We report a single center, retrospective, consecutive surgical case series of 113 eyes that underwent 25 G vitrectomy (rhegmatogenous retinal detachment or proliferative vitreoretinopathy, 49 eyes; epiretinal membrane, 18 eyes; proliferative diabetic retinopathy, 17 eyes; vitreous opacity or vitreous hemorrhage, 11 eyes; macular hole, 11 eyes; vitreomacular traction syndrome, 4 eyes; and luxation of intraocular lens, 3 eyes).

    Results: This system was successfully used to perform hybrid vitrectomy in the difficult cases, such as proliferative vitreoretinopathy and proliferative diabetic retinopathy. Read More
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    Fractal dimension and lacunarity analysis of retinal microvascular morphology in hypertension and diabetes.
    Microvasc Res 2018 Feb 22;118:36-43. Epub 2018 Feb 22.
    Faculty for Information Systems and Technologies, University of Donja Gorica, Podgorica, Montenegro.
    Hypertension and diabetes mellitus represent modifiable risk factors for vascular disease. They cause microvascular remodeling, and ultimately result in end-organ damage. Therefore, development of methods for noninvasive quantification of the effects of hypertension and diabetes mellitus on microvasculature is of paramount importance. Read More
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    Comparison of Subjective Assessment and Precise Quantitative Assessment of Lesion Distribution in Diabetic Retinopathy.
    JAMA Ophthalmol 2018 Feb 22. Epub 2018 Feb 22.
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California.
    Importance: Predominantly peripheral disease in eyes with nonproliferative diabetic retinopathy (DR) is suggested as a potential strong risk factor for progression to proliferative disease. However, the reliability and optimal method for the assessment of lesion distribution are still uncertain.

    Objective: To compare agreement between subjective assessment and precise quantification of lesion burden in ultrawidefield (UWF) images of eyes with DR. Read More
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    Ranibizumab-induced retinal reperfusion and regression of neovascularization in diabetic retinopathy: An angiographic illustration.
    Am J Ophthalmol Case Rep 2018 Mar 4;9:41-44. Epub 2018 Jan 4.
    Department of Vitreo-Retina, Giridhar Eye Institute, Ponneth Temple Road, Kadavanthara, Kochi, India.
    Purpose: To report regression of neovascularization and reperfusion of ischemic areas of the retina on Wide-field Digital Fluorescein Angiography following anti-vascular endothelial growth factor injections in a patient with active Proliferative Diabetic Retinopathy.

    Observations: Case report of sixty-one-year-old male patient with proliferative diabetic retinopathy and diabetic macular edema documented on wide field digital fluorescein angiography. The patient was treated with three intravitreal injections of ranibizumab given at monthly intervals. Read More
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