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    Long-term Effect of Panretinal Photocoagulation on Spectral Domain Optical Coherence Tomography Measurements in Diabetic Retinopathy.
    Curr Eye Res 2017 Mar 24:1-5. Epub 2017 Mar 24.
    a Department of Ophthalmology , Chungnam National University College of Medicine , Daejeon , South Korea.
    Purpose: To evaluate the effects of panretinal photocoagulation on spectral domain optical coherence tomography measurements in diabetic retinopathy by comparing the thicknesses of the central macula, retinal nerve fiber layer, and ganglion cell layer, we used a Cirrus HD OCT® (Carl Zeiss Meditec, Dublin, CA, USA) in normal and diabetic retinopathy cohorts.

    Methods: We analyzed patients who visited our retinal clinic between May 2013 and July 2014. The patients were classified into four groups: normal (Group A), diabetes without diabetic retinopathy (Group B), severe nonproliferative or proliferative diabetic retinopathy (Group C), and at least 3 years after panretinal photocoagulation treatment (Group D). Read More

    Association of increased levels of MCP-1 and cathepsin-D in young onset type 2 diabetes patients (T2DM-Y) with severity of diabetic retinopathy.
    J Diabetes Complications 2017 Mar 10. Epub 2017 Mar 10.
    Department of Cell and Molecular Biology and Dr. Rema Mohan High-Throughput Screening (HTS) Lab, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai 600086, India.. Electronic address:
    Aim: Young onset type 2 diabetes patients (T2DM-Y) have been shown to possess an increased risk of developing microvascular complications particularly diabetic retinopathy. However, the molecular mechanisms are not clearly understood. In this study, we investigated the serum levels of monocyte chemotactic protein 1 (MCP-1) and cathepsin-D in patients with T2DM-Y without and with diabetic retinopathy. Read More

    QUANTIFICATION OF RETINAL VESSEL TORTUOSITY IN DIABETIC RETINOPATHY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
    Retina 2017 Mar 22. Epub 2017 Mar 22.
    Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
    Purpose: To investigate the association of vessel tortuosity with severity of diabetic retinopathy (DR) using optical coherence tomography angiography.

    Methods: We retrospectively analyzed 30 healthy eyes and 121 eyes of diabetic subjects with no DR, mild nonproliferative DR (NPDR), moderate to severe NPDR and proliferative DR (PDR). Binarized images were used to quantify the vessel tortuosity, vessel density, foveal avascular zone (FAZ) area, and FAZ acircularity. Read More

    PREDICTING VISUAL OUTCOMES OF SECOND EYE VITRECTOMY FOR PROLIFERATIVE DIABETIC RETINOPATHY.
    Retina 2017 Mar 22. Epub 2017 Mar 22.
    *Oxford Eye Hospital, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; †Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; ‡Eye Clinic University Medical Center Ljubljana, Ljubljana, Slovenia; and §Faculty of Medicine, University Ljubljana, Ljubljana, Slovenia.
    Purpose: To investigate predictive factors for visual outcome in the second operated eye of patients undergoing bilateral vitrectomy for proliferative diabetic retinopathy.

    Methods: Clinical records of 55 patients undergoing bilateral vitrectomy for proliferative diabetic retinopathy at the University Eye Hospital Ljubljana between January 2009 and December 2014 were examined retrospectively. Statistical analysis was performed to identify variables associated with good visual outcomes. Read More

    Pupillary responses in non-proliferative diabetic retinopathy.
    Sci Rep 2017 Mar 23;7:44987. Epub 2017 Mar 23.
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1855 W. Taylor St., Chicago, IL 60612, USA.
    The goal of this study was to determine the extent of rod-, cone-, and melanopsin-mediated pupillary light reflex (PLR) abnormalities in diabetic patients who have non-proliferative diabetic retinopathy (NPDR). Fifty diabetic subjects who have different stages of NPDR and 25 age-equivalent, non-diabetic controls participated. PLRs were measured in response to full-field, brief-flash stimuli under conditions that target the rod, cone, and intrinsically-photosensitive (melanopsin) retinal ganglion cell pathways. Read More

    Acute macular edema and peripapillary soft exudate after pancreas transplantation with accelerated progression of diabetic retinopathy.
    J Chin Med Assoc 2017 Mar 18. Epub 2017 Mar 18.
    Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Surgery, National Yang-Ming University, School of Medicine, Taipei, Taiwan, ROC.
    Background: The effect of pancreas transplantation on diabetic retinopathy remains inconclusive. Herein, we report six patients with type 1 diabetes mellitus (DM) who underwent pancreas transplantation and developed acute macular edema and peripapillary soft exudate with rapid progression to proliferative diabetic retinopathy.

    Methods: In this retrospective observational study, diabetic patients who underwent pancreas transplantation in a single medical center and developed symptomatic acute macular edema and peripapillary soft exudate within 3 months after the operation were enrolled. Read More

    A Review of Ranibizumab for the Treatment of Diabetic Retinopathy.
    Ophthalmol Ther 2017 Mar 21. Epub 2017 Mar 21.
    Mayo School of Medicine, Jacksonville, FL, USA.
    Introduction: Laser photocoagulation has been the standard treatment for diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) for several decades. The discovery of vascular endothelial growth factor (VEGF) and the subsequent determination of its critical role in the development DME and PDR has led to the development of VEGF inhibitory drugs. Ranibizumab was the first anti-VEGF drug approved for the treatment of both DME and diabetic retinopathy in eyes with DME. Read More

    The Prevalence of Diabetic Retinopathy in Australian Adults with Self-Reported Diabetes: The National Eye Health Survey.
    Ophthalmology 2017 Mar 15. Epub 2017 Mar 15.
    Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, Melbourne, Australia.
    Purpose: To determine the prevalence of and factors associated with diabetic retinopathy (DR) among non-Indigenous and Indigenous Australian adults with self-reported diabetes.

    Design: Population-based cross-sectional study.

    Participants: Non-Indigenous Australians (50-98 years of age) and Indigenous Australians (40-92 years of age) with known diabetes. Read More

    Evaluation of vitreous levels of advanced glycation end products and angiogenic factors as biomarkers for severity of diabetic retinopathy.
    Int Ophthalmol 2017 Mar 15. Epub 2017 Mar 15.
    Department of Medicine, Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
    Background/aims: Glyceraldehyde-derived advanced glycation end products (glycer-AGE; also called Toxic-AGE [TAGE]) play a crucial role in the pathogenesis of diabetic angiopathy. However, the relationships between vitreous glycer-AGE levels and diabetic retinopathy (DR) severity, and between glycer-AGE levels and the levels of other angiogenic factors remain unknown. We investigated the correlation between levels of vitreous biomarkers, including glycer-AGE and angiogenic factors (vascular endothelial growth factor [VEGF], interleukin [IL]-8, leptin, placental growth factor [PlGF], endoglin, and fibroblast growth factor [FGF]-2) in patients with DR, using three DR staging groups. Read More

    Association of Skin Intrinsic Fluorescence with Retinal Microvascular Complications of Long Term Type 1 Diabetes in the Wisconsin Epidemiologic Study of Diabetic Retinopathy.
    Ophthalmic Epidemiol 2017 Mar 13:1-6. Epub 2017 Mar 13.
    a Department of Ophthalmology and Visual Sciences , University of Wisconsin School of Medicine and Public Health , Madison , WI , USA.
    Objective: To determine the association between skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation endproducts and oxidative stress in skin, and retinal microvascular complications of long duration type 1 diabetes, proliferative diabetic retinopathy (PDR) and macular edema.

    Methods: A cross-sectional cohort study of persons with type 1 diabetes in the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) who participated in a 32-year follow-up examination in 2012-2014. Subjects underwent a physical examination, answered a health questionnaire, and had fundus photographs taken. Read More

    Retinal pigment epithelium-secretome: A diabetic retinopathy perspective.
    Cytokine 2017 Mar 7;95:126-135. Epub 2017 Mar 7.
    Stem Cell Research Laboratory, GROW Laboratory, Narayana Nethralaya Foundation, Bangalore, India. Electronic address:
    Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE is a highly specialized pigmented layer regulating not only physiological functions such as transport of nutrients, ions, absorption of light, phagocytosis of photoreceptor membranes, but also secretion of a number of cytokines, chemokines, angiogenic and anti-angiogenic factors. Read More

    Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus.
    Clin Ophthalmol 2017 2;11:481-486. Epub 2017 Mar 2.
    Department of Optometry and Vision Sciences, Sulaiman Al Habib Hospital, Riyadh, Saudi Arabia.
    Purpose: This study was conducted to compare the corneal endothelial cell density (ECD), morphological features, and central corneal thickness (CCT) in type 2 diabetes mellitus (DM) with age-matched, nondiabetic control subjects using EM-3000 Specular Microscope.

    Study Design: This was a prospective, hospital-based, nonrandomized, case-control, observational, and quantitative study.

    Subjects And Methods: The study included 57 patients (57 eyes) with type 2 DM and 45 control (nondiabetic) subjects (45 eyes). Read More

    Association of serum levels of anti-myeloperoxidase antibody with retinal photoreceptor ellipsoid zone disruption in diabetic retinopathy.
    J Diabetes Complications 2017 Feb 28. Epub 2017 Feb 28.
    Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. Electronic address:
    Aim: To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy.

    Methods: Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n=20); non-proliferative diabetic retinopathy (NPDR; n=18); proliferative diabetic retinopathy (PDR; n=16)] and healthy controls (n=20) between the ages of 40 and 65years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ. Read More

    Bevacizumab and Panretinal photocoagulation protect against ocular hypertension after posterior subtenon injection of triamcinolone acetonide for diabetic macular edema.
    J Formos Med Assoc 2016 Oct 27. Epub 2016 Oct 27.
    Division of Biostatistics, Graduate Institute of Epidemiology & Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: To analyze the prognostic factors for ocular hypertension after posterior subtenon injection of triamcinolone acetonide (PSTA) for the treatment of diabetic macular edema (DME).

    Methods: Patients who received PSTA for DME from January 2006 to December 2011 were enrolled retrospectively and were followed until December 2012 in one hospital. Modified Cox regression models were used to analyze the factors associated with ocular hypertension, which was defined as an intraocular pressure>21 mmHg after PSTA. Read More

    The effect of laser pan-retinal photocoagulation with or without intravitreal bevacizumab injections on the OCT-measured macular choroidal thickness of eyes with proliferative diabetic retinopathy.
    Clinics (Sao Paulo) 2017 Feb 1;72(2):81-86. Epub 2017 Feb 1.
    Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Oftalmologia, São Paulo/SP, Brazil.
    Objectives:: To investigate the effect of laser pan-retinal photocoagulation with or without intravitreal bevacizumab injections on macular choroidal thickness parameters in eyes with high-risk proliferative diabetic retinopathy.

    Methods:: High-risk proliferative diabetic retinopathy patients undergoing laser treatment were prospectively enrolled in this study. One eye was randomly selected for laser treatment combined with bevacizumab injections, study group, whereas the corresponding eye was subjected to laser treatment alone, control group. Read More

    Vitreous and plasma changes of endothelin-1, adrenomedullin and vascular endothelium growth factor in patients with proliferative diabetic retinopathy.
    Eur Rev Med Pharmacol Sci 2017 Feb;21(4):662-668
    Department of Medical-Surgical Sciences and Biotechnologies, U.O.S. Ophthalmology, "Sapienza" University of Rome, Terracina, Italy.
    Objective: To assess vitreous and plasma changes of vascular endothelial growth factor A (VEGF-A), adrenomedullin (ADM) and endothelin-1 (ET-1) in proliferative diabetic retinopathy (PDR).

    Patients And Methods: 9 patients with PDR in type 2 diabetes (T2DM) and 11 age-matched non-diabetic patients were enrolled. The levels of VEGF-A, ADM and ET-1 were measured using an enzyme (ELISA) and a radioimmunoassay (RIA) both in vitreous and plasma samples. Read More

    Neovascular glaucoma after vitrectomy in patients with proliferative diabetic retinopathy.
    Medicine (Baltimore) 2017 Mar;96(10):e6263
    Department of Ophthalmology and Visual Science, St. Vincent's Hospital, College of Medicine, Catholic University of Korea, Suwon, Kyunggi-do, South Korea.
    To evaluate the prevalence and risk factors of neovascular glaucoma (NVG) after vitrectomy in patients with vitreous hemorrhage associated with proliferative diabetic retinopathy (PDR). This retrospective, noncomparative, observational study included 127 eyes of 127 patients with PDR who received vitrectomy with a follow-up period of at least 6 months. The prevalence of NVG and associated risk factors were assessed including sex, age, previous panretinal photocoagulation, baseline intraocular pressure, combined phacovitrectomy, and pretreatment with intravitreal bevacizumab (IVB) before vitrectomy for the treatment of vitreous hemorrhage. Read More

    NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.
    Acta Ophthalmol 2017 Mar 8. Epub 2017 Mar 8.
    School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
    Purpose: Innate immunity and dysregulation of inflammatory processes play a role in vascular diseases like atherosclerosis or diabetes. Nucleotide-binding domain and Leucine-rich repeat Receptor containing a Pyrin domain 3 (NLRP3) inflammasomes are pro-inflammatory signalling complexes that were found in 2002. In addition to pathogens and other extracellular threats, they can be activated by various endogenous danger signals. Read More

    Characteristics of patients with spontaneous dislocation of in-the-bag intraocular lens after pars plana vitrectomy.
    Jpn J Ophthalmol 2017 Mar 7. Epub 2017 Mar 7.
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-0856, Japan.
    Purpose: To determine the characteristics of eyes with late in-the-bag dislocation of an intraocular lens (IOL) after pars plana vitrectomy (PPV).

    Methods: Fourteen eyes of 14 patients with a dislocated IOL after PPV were studied retrospectively. The data collected from the medical charts included the age, sex, history of eye diseases, axial length, and interval from PPV to time of IOL dislocation. Read More

    Automatic detection of neovascularization on optic disk region with feature extraction and support vector machine.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:1324-1327
    Neovascularization (NV) is a definitive indicator for the onset of Proliferative Diabetic Retinopathy (PDR). The new vessels are fragile and prone to bleed, leading to high risk of sudden vision loss. Automatic detection of NV is an important task in automatic Diabetic Retinopathy (DR) screening as a consequence of the unmet requirement between the growing number of DR patients and limited number of ophthalmologists. Read More

    Automated detection of neovascularization for proliferative diabetic retinopathy screening.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:1300-1303
    Neovascularization is the primary manifestation of proliferative diabetic retinopathy (PDR) that can lead to acquired blindness. This paper presents a novel method that classifies neovascularizations in the 1-optic disc (OD) diameter region (NVD) and elsewhere (NVE) separately to achieve low false positive rates of neovascularization classification. First, the OD region and blood vessels are extracted. Read More

    Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls.
    PLoS One 2017 6;12(3):e0173379. Epub 2017 Mar 6.
    Department of Ophthalmology, University of Groningen, University Medical Center Groningen (UMCG), the Netherlands.
    Purpose: Advanced glycation endproducts (AGEs) and their precursors α-dicarbonyls are implicated in the progression of diabetic retinopathy. The purpose of this study was to assess AGEs and α-dicarbonyls in the vitreous of patients with type 2 diabetes mellitus (T2DM) with early stages or absence of diabetic retinopathy.

    Methods: We examined vitreous samples obtained during vitrectomy from 31 T2DM patients presenting themselves with rhegmatogenous retinal detachment and compared these to 62 non-diabetic rhegmatogenous retinal detachment patients, matched on age, estimated glomerular filtration rate, smoking, intra-ocular lens implantation, and proliferative vitreoretinopathy. Read More

    Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy.
    Exp Eye Res 2017 Feb 28;159:1-15. Epub 2017 Feb 28.
    Eye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China. Electronic address:
    Aberrant neovascularization is a consequence of inappropriate angiogenic signaling and contributes to several diseases. Although many regulators of pathogenic angiogenesis have been identified, the understanding of this process remains incomplete. Galectin-1 (Gal-1), as a homodimeric protein with a single carbohydrate-recognition domain, is implicated in several pathologic processes, including angiogenesis; however, its involvement in retinal neovascularization (RNV) remains unknown. Read More

    Diabetic phenotype of transgenic pigs introduced by dominant-negative mutant hepatocyte nuclear factor 1α.
    J Diabetes Complications 2017 Feb 13. Epub 2017 Feb 13.
    Meiji University International Institute for Bio-Resource Research, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan; Laboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan. Electronic address:
    Aim: The present study aimed to identify the characteristics of genetically modified pigs carrying a mutant human gene as a research model for diabetes and its complications.

    Methods: We developed a transgenic cloned pig (founder, male) carrying a mutant gene, i.e. Read More

    Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial.
    Croat Med J 2017 Feb;58(1):49-55
    Aleksej Medić, Ulica Velimira Terzića 7, 21000 Split, Croatia,
    Aim: To determine if preoperative treatment with a topical non-steroidal anti-inflammatory drug (NSAID) lowers the concentration of intraocular interleukin (IL)-12 and the incidence of postoperative macular edema in patients with non-proliferative diabetic retinopathy undergoing cataract surgery.

    Methods: A total of 55 patients were randomized to diclofenac (n=27) or placebo (n=28). Patients receiving diclofenac started preoperative treatment with 0. Read More

    The Role of Dyslipidemia Control in the Progression of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus.
    Diabetes Ther 2017 Feb 28. Epub 2017 Feb 28.
    2nd Department of Ophthalmology, University of Athens, Athens, Greece.
    Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM) and is considered as the leading cause of visual impairment in working-aged adults worldwide. Dyslipidemia has been associated with DR, but not with progression to the proliferative form of DR, although the exact role in the pathogenesis of DR and diabetic macular edema (DME) remains controversial. As a result, a reasonable question arising is whether control of dyslipidemia may alter the course of DR. Read More

    Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy.
    Invest Ophthalmol Vis Sci 2017 Feb;58(2):1346-1351
    Vanderbilt Genetics Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States.
    Purpose: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes.

    Methods: Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank. Read More

    Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization.
    Invest Ophthalmol Vis Sci 2017 Feb;58(2):1208-1217
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
    Purpose: To determine the relationship between the different isoforms of apolipoprotein E (ApoE) and retinal neovascularization.

    Methods: The concentrations of ApoE and VEGF in vitreous humor samples with either a macular hole (MH), or diabetic macular edema (DME), or proliferative diabetic retinopathy (PDR) with or without intravitreal injection of bevacizumab (IVB) were measured by ELISA. The effects of each isoform of ApoE on human retinal microvascular endothelial cells (HRMECs) in culture or on the retina of oxygen-induced retinopathy (OIR) mice were investigated. Read More

    Retinal neurodegeneration in patients with type 1 diabetes mellitus: the role of glycemic variability.
    Acta Diabetol 2017 Feb 25. Epub 2017 Feb 25.
    Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
    Aims: Recent studies have identified neuroretinal abnormalities in persons affected by diabetes mellitus, before the onset of microvascular alterations. However, the role of glycemic variability (GV) on early retinal neurodegeneration is still not clarified.

    Methods: To explore the relationship between glycemic control and neuroretinal characteristics, 37 persons with Type 1 diabetes mellitus (Type 1 DM) divided into two groups with no signs (noRD) and with mild non-proliferative diabetic retinopathy (NPDR) compared to 13 healthy control participants (C) were recruited. Read More

    Slow-Release Dexamethasone in Proliferative Vitreoretinopathy: A Prospective, Randomized Controlled Clinical Trial.
    Ophthalmology 2017 Feb 22. Epub 2017 Feb 22.
    Moorfields Eye Hospital, London, United Kingdom; NIHR Clinical Research Facility at Moorfields Eye Hospital, London, United Kingdom.
    Purpose: To test the hypothesis that adjunctive slow-release dexamethasone implant (Ozurdex; Allergan Inc, Irvine, CA) can improve the outcomes of vitreoretinal surgery for established proliferative vitreoretinopathy (PVR).

    Design: A 2-year, single-center, prospective, participant- and surgeon-masked randomized controlled clinical trial (EudraCT No. 2011-004498-96). Read More

    [Automatic Retinal Oxymetry in Patients with Diabetic Retinopathy].
    Cesk Slov Oftalmol 2016 ;72(5):182-186
    Aim: To determine if oxygen saturation in retinal vessels depends on the degree of diabetic retinopathy.

    Material And Methods: A prospective study comparing values of oxygen saturation in retinal arteries, veins, and arterio - venous (A-V) difference in healthy persons and in patients with diagnosed diabetes. The study included 114 eyes of 76 patients with diagnosed diabetes, and 57 eyes of 57 patients without diabetes as a control group. Read More

    DOUBLE ARCUATE RELAXING RETINOTOMY FOR A LARGE MACULAR HOLE.
    Retin Cases Brief Rep 2017 Feb 17. Epub 2017 Feb 17.
    Istanbul Retina Institute, Istanbul, Turkey.
    Purpose: To describe double arcuate relaxing retinotomy as an alternative surgical technique in a case with a secondary large macular hole.

    Methods: The management of a patient who developed a large macular hole and macular tractional rhegmatogenous retinal detachment after pars plana vitrectomy for proliferative diabetic retinopathy was retrospectively assessed. Despite surgical procedures, such as dissection of a preretinal membrane from the retina and peeling of the retinal internal limiting membrane, the macular hole could not be closed. Read More

    Stronger relationship of serum apolipoprotein A-1 and B with diabetic retinopathy than traditional lipids.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):102-105
    Department of Physiology, S. P. Medical College, Bikaner, Rajasthan, India.
    Aim: Diabetic retinopathy (DR) is the most common preventable cause of blindness where early detection and treatment can be sight-saving. Search for biomarkers of the disease has been relentless. We aimed to determine whether lipoproteins apolipoproteins A1 and B1 (Apo-A1 and Apo-B1) have stronger associations with DR in contrast to conventionally measured low-density lipoprotein (LDL) and high-density lipoprotein cholesterol levels. Read More

    Nationwide diabetes-related lower extremity amputation rates in secondary care treated patients with diabetes in the Netherlands (DUDE-7).
    J Diabetes Complications 2017 Apr 2;31(4):675-678. Epub 2017 Feb 2.
    Medical Research group, Langerhans, Dr Spanjaardweg 11, 8025 BT Zwolle, The Netherlands; Department of Internal Medicine, Gelre Hospital, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands.
    Aims: To estimate the annual amputation rate in all secondary care treated patients with diabetes in the Netherlands and specifically in patients known with diabetic retinopathy.

    Methods: A nationwide population-based retrospective cohort study was performed including the years 2007-2011. Data of patients were retrieved from reimbursement registries for hospital care from a nationwide insurance database including codes for diabetes, retinopathy and amputation. Read More

    Acircularity index and axis ratio of the foveal avascular zone in diabetic eyes and healthy controls measured by optical coherence tomography angiography.
    Vision Res 2017 Feb 26. Epub 2017 Feb 26.
    Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY, USA; New York Eye and Ear Infirmary of Mount Sinai, 310 East 14th Street, New York, NY, USA. Electronic address:
    Given the complexity of the current system used to stage diabetic retinopathy (DR) and the risks and limitations associated with intravenous fluorescein angiography (IVFA), noninvasive quantification of DR severity is desirable. We examined the utility of acircularity index and axis ratio of the foveal avascular zone (FAZ), metrics that can noninvasively quantify the severity of diabetic retinopathy without the need for axial length to correct for individual retinal magnification. A retrospective review was performed of type 2 diabetics and age-matched controls imaged with optical coherence tomography angiography (OCTA). Read More

    Optical Coherence Tomographic Angiography in Type 2 Diabetes and Diabetic Retinopathy.
    JAMA Ophthalmol 2017 Feb 16. Epub 2017 Feb 16.
    Vitreo-retinal Department, Singapore National Eye Center, Singapore, Singapore2Singapore Eye Research Institute, Singapore, Singapore3Duke-National University Singapore Medical School, Singapore, Singapore.
    Importance: Optical coherence tomographic angiography (OCT-A) is able to visualize retinal microvasculature without the need for injection of fluorescein contrast dye. Nevertheless, it is only able to capture a limited view of macula and does not show leakage.

    Objectives: To evaluate the retinal microvasculature using OCT-A in patients with type 2 diabetes as well as the association of OCT-A characteristics with diabetic retinopathy (DR) and systemic risk factors. Read More

    Long-term survival following diabetic vitrectomy.
    N Z Med J 2017 Feb 17;130(1450):69-77. Epub 2017 Feb 17.
    Consultant Ophthalmologist, Department of Ophthalmology, Waikato District Health Board, Hamilton.
    Aim: To update long-term survival data on patients with proliferative diabetic retinopathy undergoing vitrectomy and to identify associated risk factors.

    Methods: Retrospective clinical record review at a single New Zealand tertiary referral centre. A total of 182 eyes that underwent a vitrectomy for a diabetic vitreous haemorrhage and/or tractional retinal detachment between March 2000 and December 2010 were included. Read More

    EFFECT OF AN INTRAVITREAL DEXAMETHASONE IMPLANT ON DIABETIC MACULAR EDEMA AFTER CATARACT SURGERY.
    Retina 2017 Feb 10. Epub 2017 Feb 10.
    *IIS-Aragon, Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain; †University of Zaragoza, Zaragoza, Spain; ‡Department of Ophthalmology, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia; §Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand; and ¶Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.
    Purpose: To analyze the effects of a dexamethasone intravitreal implant (DEX; Ozurdex 700 μg; Allergan) administered immediately after cataract surgery in diabetic patients.

    Methods: This prospective, single-arm, open label study (NCT01748487 at ClinicalTrials.gov) involved Type 2 diabetic patients with at least mild diabetic retinopathy (DR) who underwent cataract surgery and DEX insertion after phacoemulsification, and intraocular lens implantation were enrolled. Read More

    CHOROIDAL THICKNESS IN DIABETIC RETINOPATHY ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY.
    Retina 2017 Feb 10. Epub 2017 Feb 10.
    *Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; †Faculty of Medicine, University of Coimbra, Coimbra, Portugal; ‡Department of Ophthalmology, Coimbra University Hospital, Coimbra, Portugal; §Association for Innovation and Biomedical Research on Light, Coimbra, Portugal; and ¶School of Allied Health Technologies, Polytechnic Institute of Porto, Porto, Portugal.
    Purpose: To compare the choroidal thickness (CT) of diabetic eyes (different stages of disease) with controls, using swept-source optical coherence tomography.

    Methods: A multicenter, prospective, cross-sectional study of diabetic and nondiabetic subjects using swept-source optical coherence tomography imaging. Choroidal thickness maps, according to the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, were obtained using automated software. Read More

    Changes in choroidal thickness in patients with diabetic retinopathy.
    Int Ophthalmol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
    Purpose: To investigate the changes in choroidal thickness (ChT) following panretinal photocoagulation (PRP) for diabetic retinopathy (DR) and compare ChT in relation to DR severity.

    Methods: Thirty-two eyes [19 eyes with proliferative DR (PDR) and 13 eyes with severe nonproliferative DR (NPDR)] for which PRP was necessary were analyzed. ChT was measured before PRP and at 1, 3, and 6 months after PRP using the swept-source optical coherence tomography. Read More

    [Indications for Retinal Laser Therapy Revisited].
    Klin Monbl Augenheilkd 2017 Feb 10. Epub 2017 Feb 10.
    Zentrum für Augenheilkunde, Universität zu Köln.
    Background Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications for the use of laser treatment need to be reviewed carefully, especially with respect to their significance in first line therapy. Read More

    Comparison of Efficacy and Side Effects of Multispot Lasers and Conventional Lasers for Diabetic Retinopathy Treatment.
    Turk J Ophthalmol 2017 Jan 17;47(1):34-41. Epub 2017 Jan 17.
    Marmara University Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey.
    Panretinal photocoagulation (PRP) is a standard treatment for proliferative diabetic retinopathy. Conventional laser (CL) therapy is performed in one or more sessions in single spot mode. Visual disabilities have been reported after treatment with CL, including central vision loss due to macular edema and peripheral visual field loss resulting from extensive inner retinal scarring. Read More

    Extended targeted retinal photocoagulation versus conventional pan-retinal photocoagulation for proliferative diabetic retinopathy in a randomized clinical trial.
    Int Ophthalmol 2017 Feb 6. Epub 2017 Feb 6.
    Ophthalmology Department and Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Purpose: To determine the clinical efficacy of extended targeted retinal photocoagulation (ETRP) compared to conventional panretinal photocoagulation (CPRP) in proliferative diabetic retinopathy (PDR).

    Methods: In a single-masked randomized clinical trial, 270 eyes of 234 patients with naïve early or high-risk PDR were randomly assigned to receive either CPRP or ETRP (135 eyes, each treatment arm). Best-corrected visual acuity (BCVA) measurement, fundus examination, wide-field fluorescein angiography (WFFA) and optical coherence tomography were carried out before and 3 months after retinal photocoagulation. Read More

    Ocular Inflammatory Disease as a Predictor for In-Hospital Mortality in Patients Hospitalized with Disseminated Tuberculosis.
    Cureus 2017 Jan 5;9(1):e956. Epub 2017 Jan 5.
    Lilavati Hospital.
    Aim: To ascertain whether the presence of ocular inflammatory disease is a predictor for death in patients hospitalized with disseminated tuberculosis.

    Methods: This is an IRB-approved retrospective study of patients admitted with a diagnosis of disseminated tuberculosis within a seven-year period (2002-2009). The following data was collected from each record: age, sex, details of previous surgeries or therapy, the findings of anterior segment examination, the findings of dilated indirect ophthalmoscopy, systemic findings, investigations done, treatment rendered, and final status (died or discharged). Read More

    Lower prevalence of proliferative diabetic retinopathy in elderly onset patients with diabetes.
    Diabetes Res Clin Pract 2017 Mar 21;125:47-52. Epub 2016 Sep 21.
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. Electronic address:
    Aims: To assess diabetic retinopathy (DR) prevalence between elderly onset and younger onset diabetes with similar diabetes duration and evaluate the association between DR prevalence and serum insulin-like growth factor 1 (IGF-1) levels.

    Methods: A total of 1787 patients with diabetes were enrolled between January 2010 and November 2015. Fundoscopy examination was performed. Read More

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