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    Chlorogenic acid attenuates diabetic retinopathy by reducing VEGF expression and inhibiting VEGF-mediated retinal neoangiogenesis.
    Vascul Pharmacol 2017 Nov 13. Epub 2017 Nov 13.
    The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:
    Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes mellitus (DM). This study aims to investigate the amelioration of chlorogenic acid (CGA) on proliferative DR (PDR) via focusing on inhibiting retinal neoangiogenesis. CGA reduced the increased cell proliferation, migration and tube formation induced by vascular endothelial growth factor (VEGF) in human retinal endothelial cells (HREC) and choroid-retinal endothelial RF/6A cells. Read More

    Retina 2017 Nov 10. Epub 2017 Nov 10.
    *Feinberg School of Medicine, Northwestern University, Chicago, Illinois; †Jaeb Center for Health Research, Tampa, Florida; ‡Paducah Retinal Center, Paducah, Kentucky; §Washington University School of Medicine, St. Louis, Missouri; ¶Medical College of Wisconsin, Milwaukee, Wisconsin; **Department of Ophthalmology, Duke University, Durham, North Carolina; and ††Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Purpose: Compare changes in retinal nerve fiber layer (RNFL) thickness between eyes assigned to intravitreous ranibizumab or panretinal photocoagulation and assess correlations between changes in RNFL and visual field sensitivity and central subfield thickness.

    Methods: Eyes with proliferative diabetic retinopathy were randomly assigned to ranibizumab or panretinal photocoagulation. Baseline and annual follow-up spectral domain optical coherence tomography RNFL imaging, optical coherence tomography macular imaging, and automated static perimetry (Humphrey visual field 60-4 algorithm) were performed. Read More

    Levels of adhesion molecules in peripheral blood correlat with stages of diabetic retinopathy and may serve as bio markers for microvascular complications.
    Cytokine 2017 Nov 10. Epub 2017 Nov 10.
    Department of Ophthalmology, Baruch Padeh Poria Medical Center, Faculty of Medicine in the Galilee Bar Ilan University, Galilee 15208, Israel.
    Background: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy.

    Methods: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus. Read More

    Gambogic acid ameliorates diabetes-induced proliferative retinopathy through inhibition of the HIF-1α/VEGF expression via targeting PI3K/AKT pathway.
    Life Sci 2017 Nov 10. Epub 2017 Nov 10.
    Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, People's Republic of China. Electronic address:
    Aims: Gambogic acid (GA) is one of active components of Chinese medicine gamboges resin. Diabetic retinopathy (DR) is a most serious microvascular complication of diabetes and also the leading cause of blindness. The aim of this study is to evaluate the beneficial effect of GA on diabetes-induced retinal angiogenesis and further explore the potential mechanisms. Read More

    Single-Spot Yellow Laser Versus Conventional Green Laser on Panretinal Photocoagulation: Patient Pain Scores and Preferences.
    Ophthalmic Surg Lasers Imaging Retina 2017 Nov;48(11):902-905
    Background And Objective: Panretinal photocoagulation (PRP) is the mainstay therapy for proliferative diabetic retinopathy. Pain during and after its application is a complication that affects patients' therapeutic adherence. This study aimed to compare pain perception and patient preference for the 577-nm yellow laser (YL-577) (LIGHTL as 577; LIGHTMED, San Clemente, CA) and the conventional 532-nm green laser (GL-532) (Purepoint Laser; Alcon, Fort Worth, TX) with PRP. Read More

    Foveal neovascularization in a patient with Type 2 diabetes mellitus.
    Oman J Ophthalmol 2017 Sep-Dec;10(3):255-256
    Guru Nanak Eye Centre, New Delhi, India.
    Retinal neovascularization in Diabetes mellitus (DM) is commonly seen at the optic disc and mid-periphery. It is rare at the fovea as the fovea is an avascular zone and there are very few case reports of foveal neovascularization in Type 1 DM. We report a case of unilateral foveal neovascularization in Type 2 DM. Read More

    Vitreous Fibronectin and Fibrinogen Expression Increased in Eyes With Proliferative Diabetic Retinopathy After Intravitreal Anti-VEGF Therapy.
    Invest Ophthalmol Vis Sci 2017 Nov;58(13):5783-5791
    Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
    Purpose: To evaluate vitreous humor (VH) protein expression profiles in patients with proliferative diabetic retinopathy (PDR), with and without intravitreal injection (IVI) of anti-vascular endothelial growth factor (anti-VEGF) before vitrectomy.

    Methods: We enrolled consecutive PDR patients who needed pars plana vitrectomy (PPV) with or without IVI or pan-retinal photocoagulation (PRP). Visual acuity, duration, and treatment of diabetes mellitus, ocular treatment history, and fundus examinations were recorded. Read More

    The profile of angiogenic factors in vitreous humor of the patients with proliferative diabetic retinopathy.
    Curr Mol Med 2017 Nov 5. Epub 2017 Nov 5.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060. China.
    Objective: To explore the expression profile of angiogenic factors associated with proliferative diabetic retinopathy (PDR).

    Methods: Undiluted vitreous humor samples were obtained from 10 diabetic patients with PDR (10 eyes) and 9 non-diabtic patients (9 eyes). The concentrations of 60 angiogenic factors in the vitreous humor samples were measured by RayBio Angiogenic Cytokine Antibody Array. Read More

    VEGF-B Levels in the Vitreous of Diabetic and Non-Diabetic Patients with Ocular Diseases and Its Correlation with Structural Parameters.
    Med Sci (Basel) 2017 Aug 9;5(3). Epub 2017 Aug 9.
    CICS-UBI-Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6201-506 Covilhã, Portugal.
    Vascular endothelial growth factor B (VEGF-B) is one of the enigmatic members of the VEGF family. The knowledge gap about VEGF-B expression and how its levels are altered in diabetic eyes were the focus of this investigation that was addressed by comparing and correlating vitreous VEGF-B between diabetic and non-diabetic patients. VEGF-B levels were measured by enzyme-linked immunosorbent assay in vitreous samples (n = 33) from diabetic (n = 25) and non-diabetic (n = 8) patients. Read More

    Association of 150-kDa oxygen-regulated protein with vascular endothelial growth factor in proliferative diabetic retinopathy.
    Acta Ophthalmol 2017 Nov 2. Epub 2017 Nov 2.
    Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, KU Leuven, Leuven, Belgium.
    Purpose: 150-kDa oxygen-regulated protein (ORP150), a member of heat-shock protein family located in endoplasmic reticulum (ER), has a critical role in secretion of vascular endothelial growth factor (VEGF). We investigated expression levels of ORP150 and correlated these levels with VEGF and total vitreous antioxidant capacity (TAC) in proliferative diabetic retinopathy (PDR). We also examined expression of ORP150 in retinas of diabetic rats and in human retinal microvascular endothelial cells (HRMEC). Read More

    Identification of proteins associated with clinical and pathological features of proliferative diabetic retinopathy in vitreous and fibrovascular membranes.
    PLoS One 2017 2;12(11):e0187304. Epub 2017 Nov 2.
    Ocular Angiogenesis Group, Departments of Ophthalmology and Medical Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
    Purpose: To identify the protein profiles in vitreous associated with retinal fibrosis, angiogenesis, and neurite formation in epiretinal fibrovascular membranes (FVMs) in patients with proliferative diabetic retinopathy (PDR).

    Methods: Vitreous samples of 5 non-diabetic control patients with vitreous debris and 7 patients with PDR membranes were screened for 507 preselected proteins using the semi-quantitative RayBio® L-series 507 antibody array. From this array, 60 proteins were selected for a custom quantitative antibody array (Raybiotech, Human Quantibody® array), analyzing 7 control patients, 8 PDR patients with FVMs, and 5 PDR patients without FVMs. Read More

    The role of SIRT1 in diabetic retinopathy.
    Biomed Pharmacother 2017 Oct 26;97:190-194. Epub 2017 Oct 26.
    Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    The prevalence of diabetes mellitus (DM), has been increasing worldwide. Diabetic retinopathy (DR) is the most common microvascular complication in diabetes. It is a multifactorial disease that occurs primarily through the long-term detrimental effects of hyperglycemia. Read More

    Novel strategy for Screening of Diabetic Retinopathy.
    J Diabetes Investig 2017 Nov 1. Epub 2017 Nov 1.
    Department of Ophthalmology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, 216-8511, Japan.
    Diabetic retinopathy is the most common cause of blindness in adults. Visual deficiency is mainly caused from clinically significant macular edema or vision-threatening proliferative diabetic retinopathy. Recent advances in the treatment modalities such as laser photocoagulation or with intraocular glucocorticoids or anti-vascular endothelial growth factor (VEGF) agents can substantially reduce loss of vision. Read More

    The RELATION study: efficacy and safety of ranibizumab combined with laser photocoagulation treatment versus laser monotherapy in NPDR and PDR patients with diabetic macular oedema.
    Acta Ophthalmol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Ophthalmology, University of Leipzig, Leipzig, Germany.
    Purpose: To assess efficacy and safety of intravitreal ranibizumab 0.5 mg plus laser (COMBI) versus laser monotherapy (LASER) in patients with visual impairment due to diabetic macular oedema (DME) in either nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) and to analyse the relevance of inner versus outer retinal thickness.

    Methods: In this double-masked, multicentre phase IIIb study, patients (N = 128) were randomized (2:1) to receive COMBI (n = 85) versus LASER (n = 43). Read More

    Distribution of Different Sized Ocular Surface Vessels in Diabetics and Normal Individuals.
    J Ophthalmic Vis Res 2017 Oct-Dec;12(4):361-367
    Department of Electrical Engineering, University of Texas at Dallas, Richardson, USA.
    Purpose: To compare the distribution of different sized vessels using digital photographs of the ocular surface of diabetic and normal individuals.

    Methods: In this cross-sectional study, red-free conjunctival photographs of diabetic and normal individuals, aged 30-60 years, were taken under defined conditions and analyzed using a Radon transform-based algorithm for vascular segmentation. The image areas occupied by vessels (AOV) of different diameters were calculated. Read More

    Total Serum Cholesterol Increases Risk for Development and Progression of Nonproliferative Retinopathy in Patients with Type 1 Diabetes Without Therapeutic Intervention: Prospective, Observational Study.
    Arch Med Res 2017 Oct 28. Epub 2017 Oct 28.
    Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, Zagreb, Croatia; Medical School, University of Zagreb, Zagreb, Croatia.
    Introduction: Results from studies investigating relationship between serum lipids and risk of development and progression of diabetic retinopathy (DR) in patients with type 1 diabetes (T1DM) are not consistent. The objective of this study was to explore the relationship between serum lipids and risk of development and progression of nonproliferative diabetic retinopathy (NPDR) in T1DM with normal renal function and with no therapeutic intervention that might influence on retinopathy and serum lipids status.

    Methods: A total of 103 T1DM with normal renal function (urinary albumin excretion rate <30 mg/24 h, estimated glomerular filtration rate (eGFR) >60 mL min(‒1)1. Read More

    Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data.
    Diabetes Metab J 2017 Oct;41(5):393-404
    Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
    Background: This is part of a prospective study carried out as a national project to secure standardized public resources for type 2 diabetes mellitus (T2DM) patients in Korea. We compared various characteristics of long-standing T2DM patients with diabetic retinopathy (DR) and macular edema (ME).

    Methods: From September 2014 to July 2015, T2DM patients with disease duration of at least 15 years were recruited at a single university hospital. Read More

    Assessment of Neurotrophins and Inflammatory Mediators in Vitreous of Patients With Diabetic Retinopathy.
    Invest Ophthalmol Vis Sci 2017 Oct;58(12):5594-5603
    Kresge Eye Institute/Department of Ophthalmology, Wayne State University, Detroit, Michigan, United States.
    Purpose: To assess vitreous levels of inflammatory cytokines and neurotrophins (NTs) in diabetic retinopathy (DR) and elucidate their potential roles.

    Methods: A prospective study was performed on 50 vitreous samples obtained from patients with DR (n = 22) and the nondiabetic controls (n = 28). All patients were candidates for vitrectomy. Read More

    Retinal Oximetry and Vessel Diameter Measurements With a Commercially Available Scanning Laser Ophthalmoscope in Diabetic Retinopathy.
    Invest Ophthalmol Vis Sci 2017 Oct;58(12):5556-5563
    Department of Ophthalmology, University of Southern California, Los Angeles, California, United States.
    Purpose: To test the hypothesis that retinal vascular diameter and hemoglobin oxygen saturation alterations, according to stages of diabetic retinopathy (DR), are discernible with a commercially available scanning laser ophthalmoscope (SLO).

    Methods: One hundred eighty-one subjects with no diabetes (No DM), diabetes with no DR (No DR), nonproliferative DR (NPDR), or proliferative DR (PDR, all had photocoagulation) underwent imaging with an SLO with dual lasers (532 nm and 633 nm). Customized image analysis software determined the diameters of retinal arteries and veins (DA and DV) and central retinal artery and vein equivalents (CRAE and CRVE). Read More

    Anti-VEGF Therapy for Diabetic Eye Diseases.
    Asia Pac J Ophthalmol (Phila) 2017 Oct 26. Epub 2017 Oct 26.
    Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.
    Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness in the working-age population. The identification of vascular endothelial growth factor (VEGF) as a key mediator in the pathogenesis of DR has revolutionized the management of this vision-threatening disease. There is now strong evidence supporting intravitreal anti-VEGF therapy as first line in the management of sight-threatening diabetic macular edema (DME), along with a growing body of evidence to support the use of anti-VEGF drugs for proliferative DR. Read More

    Risk factors for progression of diabetic retinopathy in Alberta First Nations communities.
    Can J Ophthalmol 2017 Nov;52 Suppl 1:S19-S29
    Department of Ophthalmology, Faculty of Medicine, Dentistry, University of Alberta, Edmonton, Alta.
    Objective: The Screening for Limb, I-Eye, Cardiovascular, and Kidney Complications (SLICK) Program was implemented in 1999 to improve diabetic care for Alberta First Nations individuals living on reserve. The purpose of this review is to determine the rate and predictors of progression of diabetic retinopathy (DR) over a 10-year period.

    Design: Cohort study. Read More

    Automatic non-proliferative diabetic retinopathy screening system based on color fundus image.
    Biomed Eng Online 2017 Oct 26;16(1):122. Epub 2017 Oct 26.
    Tianjin Medical University Metabolic Diseases Hospital, Tianjin, 300070, China.
    Background: Non-proliferative diabetic retinopathy is the early stage of diabetic retinopathy. Automatic detection of non-proliferative diabetic retinopathy is significant for clinical diagnosis, early screening and course progression of patients.

    Methods: This paper introduces the design and implementation of an automatic system for screening non-proliferative diabetic retinopathy based on color fundus images. Read More

    Elevated serum fetuin-A levels are associated with grades of retinopathy in type 2 diabetic patients.
    Int Ophthalmol 2017 Oct 25. Epub 2017 Oct 25.
    Department of Biochemistry, Mengucek Gazi Education and Research Hospital, Erzincan, Turkey.
    Purpose: Fetuin-A is a physiological inhibitor of insulin receptor tyrosine kinase and thus associated with insulin resistance, metabolic syndrome, and an increased risk for type 2 diabetes mellitus (T2DM). This study aims to investigate the possible relation between the serum fetuin-A levels and the stages of diabetic retinopathy (DR) in patients with T2DM.

    Methods: This prospective study included 82 patients with T2DM and 19 age- and gender-matched healthy controls (HCs) (group 1). Read More

    Relationship between retinal vessel diameters and retinopathy in the Inter99 Eye Study.
    J Clin Transl Endocrinol 2017 Jun 21;8:22-28. Epub 2017 Mar 21.
    Center of Eye Research, Department of Ophthalmology, Oslo University Hospital and University of Oslo, Oslo, Norway.
    Purpose: To examine the association between retinal vessel diameters and retinopathy in participants with and without type 2 diabetes in a Danish population-based cohort.

    Methods: The study included 878 persons aged 30 to 60 years from the Inter99 Eye Study. Retinopathy was defined as a presence of one or more retinal hemorrhages or one or more microaneurysms. Read More

    Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography.
    Int J Ophthalmol 2017 18;10(10):1545-1551. Epub 2017 Oct 18.
    Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti 66100, Italy.
    Aim: To investigate foveal avascular zone (FAZ) and parafoveal vessel densities (PRVD) by means of optical coherence tomography angiography (OCTA) in diabetic patients with or without diabetic retinopathy (DR) and to assess the reproducibility of FAZ and PRVD measurements.

    Methods: Sixty diabetic patients (60 eyes) with different stage of DR (graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners. FAZ area in all patients was also assessed using fluorescein angiography (FA). Read More

    Nogo-B Promotes Angiogenesis in Proliferative Diabetic Retinopathy via VEGF/PI3K/Akt Pathway in an Autocrine Manner.
    Cell Physiol Biochem 2017 Oct 19;43(5):1742-1754. Epub 2017 Oct 19.
    Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
    Background/aims: Nogo-B, a conservative protein of endoplasmic reticulum, is a member of the reticulon family of proteins. Proliferative diabetic retinopathy (PDR) is the major concerning problem of diabetic retinopathy. This study explored the role of Nogo-B in the regulation of angiogenesis in PDR patients and primary human retinal endothelial cells (HRMECs). Read More

    "Epigenetic control of early neurodegenerative events in Diabetic Retinopathy by the histone deacetylase SIRT6".
    J Neurochem 2017 Oct 19. Epub 2017 Oct 19.
    Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET), 1ª Cátedra de Farmacología, Facultad de Medicina, UBA, Buenos AiresArgentina.
    Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus (DM) and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes. Moreover, glucose-induced neuron and glial cell damage may occur shortly after the onset of diabetes which makes the disease hard to diagnose at early stages. Read More

    Proliferative diabetic retinopathy characterization based on fractal features: Evaluation on a publicly available dataset.
    Med Phys 2017 Oct 17. Epub 2017 Oct 17.
    Pladema Institute, UNCPBA, Gral. Pinto 399, Tandil, Argentina.
    Purpose: Diabetic retinopathy (DR) is one of the most widespread causes of preventable blindness in the world. The most dangerous stage of this condition is proliferative DR (PDR), in which the risk of vision loss is high and treatments are less effective. Fractal features of the retinal vasculature have been previously explored as potential biomarkers of DR, yet the current literature is inconclusive with respect to their correlation with PDR. Read More

    Twenty-seven-gauge vitrectomy for combined tractional and rhegmatogenous retinal detachment involving the macula associated with proliferative diabetic retinopathy.
    Int J Retina Vitreous 2017 9;3:38. Epub 2017 Oct 9.
    Department of Ophthalmology, Río Piedras Medical Center, University of Puerto Rico, San Juan, 00909 Puerto Rico.
    Background: To report our experience using 27-gauge pars plana vitrectomy (PPV) system for treating patients with combined tractional and rhegmatogenous retinal detachments (CTRRD) involving the macula associated with proliferative diabetic retinopathy (PDR).

    Methods: Retrospective noncomparative interventional cases series of 12 patients with CTRRD associated with PDR who underwent 3-port, transconjunctival 27-gauge PPV by a single surgeon. Main outcome measures were change in Snellen best corrected visual acuity (BCVA) and occurrence of intra- and post-operative complications. Read More

    Enhanced diffusometric immunosensing with grafted gold nanoparticles for detection of diabetic retinopathy biomarker tumor necrosis factor-α.
    Biosens Bioelectron 2018 Mar 11;101:75-83. Epub 2017 Oct 11.
    Department of Biomedical Engineering, National Cheng Kung University, Taiwan.
    Diffusometry is sensitive to geometric changes of particles. Target antigens can be detected through diffusivity changes resulting from their immunoreactions by functionalizing particle surface with a specific antibody. Considering that Brownian motion is a self-driven phenomenon, diffusometric immunosensing features several characteristics, such as no-washing steps, rapid detection, high flexibility, and high sensitivity. Read More

    Quantitative analysis of neural tissues around the optic disc after panretinal photocoagulation in patients with diabetic retinopathy.
    PLoS One 2017 17;12(10):e0186229. Epub 2017 Oct 17.
    Department of Ophthalmology, University of Ulsan, College of Medicine, Ulsan University Hospital, Ulsan, South Korea.
    In this retrospective cross-sectional study, we quantitatively analyzed the tomographic features in the neural tissues around the optic disc in patients with diabetic retinopathy with and without panretinal photocoagulation. We analyzed 206 eyes, comprising 33 normal eyes in subjects without diabetes (group I), 30 eyes without diabetic retinopathy (group II), 66 eyes with non-proliferative diabetic retinopathy (group III), 45 eyes with panretinal photocoagulation (group IV), and 32 eyes with normal tension glaucoma (group V). Sequential images acquired using swept-source optical coherence tomography in three-dimensional mode were used to measure peripapillary retinal nerve fiber layer thickness, neuro-retinal rim thickness, anterior lamina cribrosa depth, prelaminar thickness, and thickness of the lamina cribrosa. Read More

    Differential association of elevated inflammatory cytokines with postoperative fibrous proliferation and neovascularization after unsuccessful vitrectomy in eyes with proliferative diabetic retinopathy.
    Clin Ophthalmol 2017 19;11:1697-1705. Epub 2017 Sep 19.
    Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences, Fukuoka.
    Background: Pars plana vitrectomy is the only treatment for advanced proliferative diabetic retinopathy (PDR). However, vitrectomy is not always successful despite current progress in vitreoretinal surgical techniques. The aim of our study was to investigate whether the vitreal concentrations of MCP-1, IL-6, IL-8, and VEGF are elevated after unsuccessful vitrectomy in patients with PDR and to investigate whether the altered levels of these cytokines are associated with the cause for the reoperation. Read More

    ANGPTL-4 induces diabetic retinal inflammation by activating Profilin-1.
    Exp Eye Res 2017 Oct 13;166:140-150. Epub 2017 Oct 13.
    Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, China. Electronic address:
    Diabetic retinopathy (DR), the most common cause of irreversible blindness in working-age adults, results in central vision loss that is caused by microvascular damage to the inner lining of the back of the eye, the retina. The aim of this work was to assess the temporal relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor, and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway(s) and upstream mediator(s) of ANGPTL-4 were then determined under high glucose (HG) conditions. Read More

    VEGF-A gene polymorphisms and responses to intravitreal ranibizumab treatment in patients with diabetic macular edema.
    Int Ophthalmol 2017 Oct 13. Epub 2017 Oct 13.
    Department of Ophthalmology, Dumlupinar University School of Medicine, 43270, Kutahya, Turkey.
    Purpose: To investigate the association between VEGF gene polymorphisms and the responses to treatment with intravitreal ranibizumab (IVR) in patients with diabetic macular edema (DME).

    Methods: This prospective study, conducted at the Kutahya Dumlupinar University Faculty of Medicine, included 95 patients with DME that were treated with IVR and 32 patients without DME despite proliferative diabetic retinopathy (PDR). The participants were divided into three groups: DME with non-proliferative diabetic retinopathy, DME with PDR, and PDR without DME; patients with DME who were treated with IVR were further divided into two groups based on their response to the treatment. Read More

    Associations of Physical Activity and Sedentary Behaviour with Vision-Threatening Diabetic Retinopathy in Indonesian Population with Type 2 Diabetes Mellitus: Jogjakarta Eye Diabetic Study in the Community (JOGED.COM).
    Ophthalmic Epidemiol 2017 Oct 12:1-7. Epub 2017 Oct 12.
    a Department of Ophthalmology, Faculty of Medicine , Universitas Gadjah Mada , Yogyakarta , Indonesia.
    Purpose: To investigate the association of physical activity (PA) and sedentary behaviour with diabetic retinopathy (DR) in type 2 diabetes adults.

    Methods: A community-based cross-sectional study of adults with type 2 diabetes. DR was assessed from disc- and macula-centred fundus photograph, and categorised into mild, moderate non-proliferative DR (NPDR), and Vision-Threatening DR (VTDR). Read More

    Improvement of Recalcitrant Diabetic Macular Edema After Peritoneal Dialysis.
    Ophthalmic Surg Lasers Imaging Retina 2017 Oct;48(10):834-837
    Nephropathy may be an independent and contributory risk factor for diabetic macular edema (DME). A 69-year-old man who had previously been treated with panretinal laser photocoagulation for proliferative diabetic retinopathy as well as with steroid and anti-vascular endothelial growth factor injections for DME declined additional treatment for the DME, which was worse in the right eye. The DME was observed without further treatment for the next 36 months. Read More

    Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy with Swept-Source Optical Coherence Tomography.
    Am J Ophthalmol 2017 Oct 5. Epub 2017 Oct 5.
    Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 243 Charles Street, Boston, MA 02114. Electronic address:
    Purpose: To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT).

    Design: Prospective cross-sectional study.

    Methods: ▪▪▪ SETTING: Multicenter PATIENT POPULATION: 143 diabetic eyes - 27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 with proliferative DR (PDR), and 64 age-matched non-diabetic control eyes. Read More

    Preoperative photocoagulation reduces corneal endothelial cell damage after vitrectomy in patients with proliferative diabetic retinopathy.
    Medicine (Baltimore) 2017 Oct;96(40):e7971
    Department of Ophthalmology, Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
    Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes and is a leading cause of visual decline and irreversible blindness. So we designed this study to investigate retrospectively the effect of preoperative photocoagulation on corneal endothelial cells after vitrectomy in patients with PDR.The study included 52 eyes of 46 patients with PDR complicated with vitreous hemorrhage, who underwent vitrectomy. Read More

    Retina 2017 Oct 3. Epub 2017 Oct 3.
    Department of Ophthalmology, Aarhus University Hospital, Aarhus C, Denmark.
    Purpose: Retinal neovascularizations in proliferative diabetic retinopathy have been proposed to develop from larger retinal venules. However, angiographic evidence suggests that the new vessels may originate from both arterioles and venules, and the vitreous oxygen tension near retinal neovascularizations is similar to that of retinal arterioles. An assessment of the oxygen saturation in neovascularizations may help characterizing the vascular origin of these vessels in proliferative diabetic retinopathy. Read More

    Role of Angiopoietins and Tie-2 in Diabetic Retinopathy.
    Electron Physician 2017 Aug 25;9(8):5031-5035. Epub 2017 Aug 25.
    Medical Biochemistry Unit, Research Institute of Ophthalmology, Giza, Egypt.
    Objective: The aim of this study was to determine the serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble vascular endothelial tyrosine kinase receptor (Tie-2) and vascular endothelial growth factor (VEGF), in the serum of type 2 diabetic patients having non-proliferative (NPDR) or proliferative diabetic retinopathy (PDR).

    Methods: One hundred patients with type 2 diabetes mellitus were involved in this cross-sectional study. They were classified into 25 diabetic patients without retinopathy, 35 patients with NPDR and 40 PDR patients. Read More

    Long-term evaluation of spontaneous release of epiretinal membrane and its possible pathogenesis.
    Clin Ophthalmol 2017 1;11:1607-1610. Epub 2017 Sep 1.
    Department of Ophthalmology, Osaka Medical College, Takatsuki.
    Purpose: To investigate the characteristics in spontaneous release of epiretinal membrane (ERM) during watchful waiting and to introduce a possible mechanism of pathogenesis as a photo essay.

    Methods: Records from all patients with ERM were obtained from Osaka Medical College Hospital from January 2001 to October 2012. Visual acuity (VA), fundus photo, and optical coherence tomography (OCT) were reviewed using the medical records. Read More

    A case of pseudoxanthoma elasticum with proliferative diabetic retinopathy.
    BMC Ophthalmol 2017 Oct 4;17(1):184. Epub 2017 Oct 4.
    Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.
    Background: To report the case of a patient with pseudoxanthoma elasticum (PXE) and proliferative diabetic retinopathy (PDR), and discuss the relationship between PXE and diabetic retinopathy (DR).

    Case Presentation: A 47-year-old man with PXE presented with angioid streaks and DR in both eyes, and bilateral panretinal photocoagulation was performed for treatment. Vitrectomy had previously been performed in his right eye for vitreous hemorrhage due to PDR. Read More

    The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy.
    PLoS One 2017 3;12(10):e0185795. Epub 2017 Oct 3.
    Department of Ophthalmology, Peking University People's Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China.
    Purpose: The Slit-Robo signal has an important role in vasculogenesis and angiogenesis. Our study examined the expression of Slit2 and its receptor, Robo1, in a rat model of streptozotocin-induced diabetes and in patients with proliferative diabetic retinopathy.

    Methods: Diabetes was induced in male Sprague-Dawley rats via a single, intraperitoneal injection of streptozotocin. Read More

    Association of functional SNP-1562C>T in MMP9 promoter with proliferative diabetic retinopathy in north Indian type 2 diabetes mellitus patients.
    J Diabetes Complications 2017 Dec 26;31(12):1648-1651. Epub 2017 Aug 26.
    Department of Molecular & Human Genetics, Banaras Hindu University, Varanasi 221005, India. Electronic address:
    Objective: Retinal angiogenesis is a hallmark of diabetic retinopathy. Matrix Metalloproteinases (MMPs) are involved in degradation of extracellular matrix (ECM). Functional SNP-1562C>T in the promoter of the MMP-9 gene results increase in transcriptional activity. Read More

    Resveratrol reverses the adverse effects of bevacizumab on cultured ARPE-19 cells.
    Sci Rep 2017 Sep 25;7(1):12242. Epub 2017 Sep 25.
    Stem Cell Lab, GROW Laboratories, Narayana Nethralaya Foundation, Bangalore, Karnataka, India.
    Age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR) are one of the major causes of blindness caused by neo-vascular changes in the retina. Intravitreal anti-VEGF injections are widely used in the treatment of wet-AMD and PDR. A significant percentage of treated patients have complications of repeated injections. Read More

    Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy.
    Curr Eye Res 2017 Sep 22:1-10. Epub 2017 Sep 22.
    a Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine , Hokkaido University , Sapporo , Japan.
    Purpose/Aim of the study: To explore the possible role of vascular adhesion protein-1 (VAP-1) via its enzymatic function as a semicarbazide-sensitive amine oxidase (SSAO) in the pathogenesis of proliferative diabetic retinopathy (PDR).

    Materials And Methods: The levels of soluble VAP-1/SSAO and the unsaturated aldehyde acrolein (ACR)-conjugated protein, N(ε)-(3-formyl-3, 4-dehydropiperidino) lysine adduct (FDP-Lys), were measured in vitreous fluid samples of PDR and non-diabetic patients using ELISA. Recombinant human VAP-1/SSAO (rhVAP-1/SSAO) was incubated with spermine, with or without semicarbazide or RTU-1096 (a specific inhibitor for VAP-1/SSAO). Read More

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