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    5364 results match your criteria Retinopathy Diabetic Proliferative

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    Retinal neurodegeneration in patients with type 1 diabetes mellitus: the role of glycemic variability.
    Acta Diabetol 2017 Feb 25. Epub 2017 Feb 25.
    Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
    Aims: Recent studies have identified neuroretinal abnormalities in persons affected by diabetes mellitus, before the onset of microvascular alterations. However, the role of glycemic variability (GV) on early retinal neurodegeneration is still not clarified.

    Methods: To explore the relationship between glycemic control and neuroretinal characteristics, 37 persons with Type 1 diabetes mellitus (Type 1 DM) divided into two groups with no signs (noRD) and with mild non-proliferative diabetic retinopathy (NPDR) compared to 13 healthy control participants (C) were recruited. Read More

    Slow-Release Dexamethasone in Proliferative Vitreoretinopathy: A Prospective, Randomized Controlled Clinical Trial.
    Ophthalmology 2017 Feb 22. Epub 2017 Feb 22.
    Moorfields Eye Hospital, London, United Kingdom; NIHR Clinical Research Facility at Moorfields Eye Hospital, London, United Kingdom.
    Purpose: To test the hypothesis that adjunctive slow-release dexamethasone implant (Ozurdex; Allergan Inc, Irvine, CA) can improve the outcomes of vitreoretinal surgery for established proliferative vitreoretinopathy (PVR).

    Design: A 2-year, single-center, prospective, participant- and surgeon-masked randomized controlled clinical trial (EudraCT No. 2011-004498-96). Read More

    Automatic detection of neovascularization on optic disk region with feature extraction and support vector machine.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:1324-1327
    Neovascularization (NV) is a definitive indicator for the onset of Proliferative Diabetic Retinopathy (PDR). The new vessels are fragile and prone to bleed, leading to high risk of sudden vision loss. Automatic detection of NV is an important task in automatic Diabetic Retinopathy (DR) screening as a consequence of the unmet requirement between the growing number of DR patients and limited number of ophthalmologists. Read More

    Automated detection of neovascularization for proliferative diabetic retinopathy screening.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:1300-1303
    Neovascularization is the primary manifestation of proliferative diabetic retinopathy (PDR) that can lead to acquired blindness. This paper presents a novel method that classifies neovascularizations in the 1-optic disc (OD) diameter region (NVD) and elsewhere (NVE) separately to achieve low false positive rates of neovascularization classification. First, the OD region and blood vessels are extracted. Read More

    [Automatic Retinal Oxymetry in Patients with Diabetic Retinopathy].
    Cesk Slov Oftalmol 2016 ;72(5):182-186
    Aim: To determine if oxygen saturation in retinal vessels depends on the degree of diabetic retinopathy.

    Material And Methods: A prospective study comparing values of oxygen saturation in retinal arteries, veins, and arterio - venous (A-V) difference in healthy persons and in patients with diagnosed diabetes. The study included 114 eyes of 76 patients with diagnosed diabetes, and 57 eyes of 57 patients without diabetes as a control group. Read More

    DOUBLE ARCUATE RELAXING RETINOTOMY FOR A LARGE MACULAR HOLE.
    Retin Cases Brief Rep 2017 Feb 17. Epub 2017 Feb 17.
    Istanbul Retina Institute, Istanbul, Turkey.
    Purpose: To describe double arcuate relaxing retinotomy as an alternative surgical technique in a case with a secondary large macular hole.

    Methods: The management of a patient who developed a large macular hole and macular tractional rhegmatogenous retinal detachment after pars plana vitrectomy for proliferative diabetic retinopathy was retrospectively assessed. Despite surgical procedures, such as dissection of a preretinal membrane from the retina and peeling of the retinal internal limiting membrane, the macular hole could not be closed. Read More

    Stronger relationship of serum apolipoprotein A-1 and B with diabetic retinopathy than traditional lipids.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):102-105
    Department of Physiology, S. P. Medical College, Bikaner, Rajasthan, India.
    Aim: Diabetic retinopathy (DR) is the most common preventable cause of blindness where early detection and treatment can be sight-saving. Search for biomarkers of the disease has been relentless. We aimed to determine whether lipoproteins apolipoproteins A1 and B1 (Apo-A1 and Apo-B1) have stronger associations with DR in contrast to conventionally measured low-density lipoprotein (LDL) and high-density lipoprotein cholesterol levels. Read More

    Nationwide diabetes-related lower extremity amputation rates in secondary care treated patients with diabetes in the Netherlands (DUDE-7).
    J Diabetes Complications 2017 Feb 2. Epub 2017 Feb 2.
    Medical Research group, Langerhans, Dr Spanjaardweg 11, 8025 BT Zwolle, The Netherlands; Department of Internal Medicine, Gelre Hospital, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands.
    Aims: To estimate the annual amputation rate in all secondary care treated patients with diabetes in the Netherlands and specifically in patients known with diabetic retinopathy.

    Methods: A nationwide population-based retrospective cohort study was performed including the years 2007-2011. Data of patients were retrieved from reimbursement registries for hospital care from a nationwide insurance database including codes for diabetes, retinopathy and amputation. Read More

    Acircularity index and axis ratio of the foveal avascular zone in diabetic eyes and healthy controls measured by optical coherence tomography angiography.
    Vision Res 2017 Feb 14. Epub 2017 Feb 14.
    Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY, USA; New York Eye and Ear Infirmary of Mount Sinai, 310 East 14th Street, New York, NY, USA. Electronic address:
    Given the complexity of the current system used to stage diabetic retinopathy (DR) and the risks and limitations associated with intravenous fluorescein angiography (IVFA), noninvasive quantification of DR severity is desirable. We examined the utility of acircularity index and axis ratio of the foveal avascular zone (FAZ), metrics that can noninvasively quantify the severity of diabetic retinopathy without the need for axial length to correct for individual retinal magnification. A retrospective review was performed of type 2 diabetics and age-matched controls imaged with optical coherence tomography angiography (OCTA). Read More

    Optical Coherence Tomographic Angiography in Type 2 Diabetes and Diabetic Retinopathy.
    JAMA Ophthalmol 2017 Feb 16. Epub 2017 Feb 16.
    Vitreo-retinal Department, Singapore National Eye Center, Singapore, Singapore2Singapore Eye Research Institute, Singapore, Singapore3Duke-National University Singapore Medical School, Singapore, Singapore.
    Importance: Optical coherence tomographic angiography (OCT-A) is able to visualize retinal microvasculature without the need for injection of fluorescein contrast dye. Nevertheless, it is only able to capture a limited view of macula and does not show leakage.

    Objectives: To evaluate the retinal microvasculature using OCT-A in patients with type 2 diabetes as well as the association of OCT-A characteristics with diabetic retinopathy (DR) and systemic risk factors. Read More

    Long-term survival following diabetic vitrectomy.
    N Z Med J 2017 Feb 17;130(1450):69-77. Epub 2017 Feb 17.
    Consultant Ophthalmologist, Department of Ophthalmology, Waikato District Health Board, Hamilton.
    Aim: To update long-term survival data on patients with proliferative diabetic retinopathy undergoing vitrectomy and to identify associated risk factors.

    Methods: Retrospective clinical record review at a single New Zealand tertiary referral centre. A total of 182 eyes that underwent a vitrectomy for a diabetic vitreous haemorrhage and/or tractional retinal detachment between March 2000 and December 2010 were included. Read More

    EFFECT OF AN INTRAVITREAL DEXAMETHASONE IMPLANT ON DIABETIC MACULAR EDEMA AFTER CATARACT SURGERY.
    Retina 2017 Feb 10. Epub 2017 Feb 10.
    *IIS-Aragon, Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain; †University of Zaragoza, Zaragoza, Spain; ‡Department of Ophthalmology, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia; §Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand; and ¶Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.
    Purpose: To analyze the effects of a dexamethasone intravitreal implant (DEX; Ozurdex 700 μg; Allergan) administered immediately after cataract surgery in diabetic patients.

    Methods: This prospective, single-arm, open label study (NCT01748487 at ClinicalTrials.gov) involved Type 2 diabetic patients with at least mild diabetic retinopathy (DR) who underwent cataract surgery and DEX insertion after phacoemulsification, and intraocular lens implantation were enrolled. Read More

    CHOROIDAL THICKNESS IN DIABETIC RETINOPATHY ASSESSED WITH SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY.
    Retina 2017 Feb 10. Epub 2017 Feb 10.
    *Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; †Faculty of Medicine, University of Coimbra, Coimbra, Portugal; ‡Department of Ophthalmology, Coimbra University Hospital, Coimbra, Portugal; §Association for Innovation and Biomedical Research on Light, Coimbra, Portugal; and ¶School of Allied Health Technologies, Polytechnic Institute of Porto, Porto, Portugal.
    Purpose: To compare the choroidal thickness (CT) of diabetic eyes (different stages of disease) with controls, using swept-source optical coherence tomography.

    Methods: A multicenter, prospective, cross-sectional study of diabetic and nondiabetic subjects using swept-source optical coherence tomography imaging. Choroidal thickness maps, according to the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, were obtained using automated software. Read More

    Changes in choroidal thickness in patients with diabetic retinopathy.
    Int Ophthalmol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
    Purpose: To investigate the changes in choroidal thickness (ChT) following panretinal photocoagulation (PRP) for diabetic retinopathy (DR) and compare ChT in relation to DR severity.

    Methods: Thirty-two eyes [19 eyes with proliferative DR (PDR) and 13 eyes with severe nonproliferative DR (NPDR)] for which PRP was necessary were analyzed. ChT was measured before PRP and at 1, 3, and 6 months after PRP using the swept-source optical coherence tomography. Read More

    [Indications for Retinal Laser Therapy Revisited].
    Klin Monbl Augenheilkd 2017 Feb 10. Epub 2017 Feb 10.
    Zentrum für Augenheilkunde, Universität zu Köln.
    Background Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications for the use of laser treatment need to be reviewed carefully, especially with respect to their significance in first line therapy. Read More

    Comparison of Efficacy and Side Effects of Multispot Lasers and Conventional Lasers for Diabetic Retinopathy Treatment.
    Turk J Ophthalmol 2017 Jan 17;47(1):34-41. Epub 2017 Jan 17.
    Marmara University Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey.
    Panretinal photocoagulation (PRP) is a standard treatment for proliferative diabetic retinopathy. Conventional laser (CL) therapy is performed in one or more sessions in single spot mode. Visual disabilities have been reported after treatment with CL, including central vision loss due to macular edema and peripheral visual field loss resulting from extensive inner retinal scarring. Read More

    Extended targeted retinal photocoagulation versus conventional pan-retinal photocoagulation for proliferative diabetic retinopathy in a randomized clinical trial.
    Int Ophthalmol 2017 Feb 6. Epub 2017 Feb 6.
    Ophthalmology Department and Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Purpose: To determine the clinical efficacy of extended targeted retinal photocoagulation (ETRP) compared to conventional panretinal photocoagulation (CPRP) in proliferative diabetic retinopathy (PDR).

    Methods: In a single-masked randomized clinical trial, 270 eyes of 234 patients with naïve early or high-risk PDR were randomly assigned to receive either CPRP or ETRP (135 eyes, each treatment arm). Best-corrected visual acuity (BCVA) measurement, fundus examination, wide-field fluorescein angiography (WFFA) and optical coherence tomography were carried out before and 3 months after retinal photocoagulation. Read More

    Ocular Inflammatory Disease as a Predictor for In-Hospital Mortality in Patients Hospitalized with Disseminated Tuberculosis.
    Cureus 2017 Jan 5;9(1):e956. Epub 2017 Jan 5.
    Lilavati Hospital.
    Aim: To ascertain whether the presence of ocular inflammatory disease is a predictor for death in patients hospitalized with disseminated tuberculosis.

    Methods: This is an IRB-approved retrospective study of patients admitted with a diagnosis of disseminated tuberculosis within a seven-year period (2002-2009). The following data was collected from each record: age, sex, details of previous surgeries or therapy, the findings of anterior segment examination, the findings of dilated indirect ophthalmoscopy, systemic findings, investigations done, treatment rendered, and final status (died or discharged). Read More

    Lower prevalence of proliferative diabetic retinopathy in elderly onset patients with diabetes.
    Diabetes Res Clin Pract 2017 Mar 21;125:47-52. Epub 2016 Sep 21.
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. Electronic address:
    Aims: To assess diabetic retinopathy (DR) prevalence between elderly onset and younger onset diabetes with similar diabetes duration and evaluate the association between DR prevalence and serum insulin-like growth factor 1 (IGF-1) levels.

    Methods: A total of 1787 patients with diabetes were enrolled between January 2010 and November 2015. Fundoscopy examination was performed. Read More

    Factors Associated with Worsening Proliferative Diabetic Retinopathy in Eyes Treated with Panretinal Photocoagulation or Ranibizumab.
    Ophthalmology 2017 Feb 1. Epub 2017 Feb 1.
    Loma Linda University Health Care, Loma Linda, California.
    Purpose: To compare rates and identify predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in eyes treated with panretinal photocoagulation (PRP) or ranibizumab.

    Design: Randomized clinical trial (55 United States sites).

    Participants: Three hundred ninety-four study eyes from 305 adults with PDR, visual acuity (VA) 20/320 or better, and no history of PRP. Read More

    Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population.
    Int J Ophthalmol 2017 18;10(1):135-139. Epub 2017 Jan 18.
    Biomedical Research Department, Autonomous University of Queretaro, Queretaro 76170, Mexico.
    Aim: To assess if the included vascular endothelial growth factor (VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus (T2DM).

    Methods: A case-control study was conducted in adult individuals with T2DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. Read More

    The role of patient's systemic characteristics and plateletcrit in developing toxic anterior segment syndrome after uneventful phaco surgery: A case-control study.
    Int Ophthalmol 2017 Jan 27. Epub 2017 Jan 27.
    Department of Ophthalmology, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
    Purpose: To compare the systemic and ocular characteristics and laboratory findings of patients developing toxic anterior segment syndrome (TASS) after uneventful phaco surgery with unaffected subjects undergoing the same surgery in the same session.

    Design: A retrospective case-control study.

    Methods: The study group consisted of 26 eyes of 26 patients who underwent uneventful phaco surgery and who went on to develop TASS, while the control group included 39 subjects who had routine phaco surgery in the same session by the same surgeon. Read More

    Intravitreal Bevacizumab for The Treatment of Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy.
    Am J Ophthalmol 2017 Jan 24. Epub 2017 Jan 24.
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 North 39(th) Street, Philadelphia, PA 19104. Electronic address:
    Purpose: To evaluate the outcomes of intravitreal bevacizumab (IVB) use in patients with a vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR).

    Design: Retrospective, interventional case series.

    Methods: Patients who presented to Scheie Eye Institute between January 2008 and January 2015 with a new VH secondary to PDR and treated with IVB were included. Read More

    Prevalence of referable, sight-threatening retinopathy in type 1 diabetes and its relationship to diabetes duration and systemic risk factors.
    Eye (Lond) 2017 Feb 27;31(2):333-341. Epub 2017 Jan 27.
    Southampton Eye Unit, University Hospital Southampton, University Hospital Southampton NHS Foundation Trust, Hampshire, UK.
    PurposeThe purpose of the study was to provide contemporary estimates for diabetic retinopathy (DR) prevalence in a well-defined UK cohort of patients with type 1 diabetes (T1DM) and investigate potential risk factors for proliferative diabetic retinopathy (PDR) and diabetic maculopathy.Patients and MethodsFour hundred and sixty four T1DM patients in North Hampshire had T1DM duration, demographic and systemic risk factor data evaluated retrospectively alongside their DR status in 2010 using logistic regression analysis.ResultsOverall prevalence of any retinopathy, PDR, and maculopathy was 71. Read More

    Association of High-Mobility Group Box-1 With Th Cell-Related Cytokines in the Vitreous of Ocular Sarcoidosis Patients.
    Invest Ophthalmol Vis Sci 2017 Jan;58(1):528-537
    Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Saitama, Japan.
    Purpose: High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in ocular sarcoidosis with those in noninflammatory vitreoretinal diseases and evaluated its association with Th cell-related and proinflammatory cytokines.

    Methods: The study group consisted of 24 patients with ocular sarcoidosis. Read More

    INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS.
    Retina 2017 Feb;37(2):344-349
    *Retina Service, Department of Ophthalmology, King George's Medical University, Lucknow, India;Departments of †Social and Preventive Medicine, and‡Pathology, King George's Medical University, Lucknow, India;§Department of Ophthalmology, Pallas Klinik, Olten, Switzerland;¶Department of Ophthalmology, University of Adelaide, Adelaide, South Australia, Australia;**Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; and††Department of Ophthalmology, Saint Louis University Eye Institute, Saint Louis University, St. Louis, Missouri.
    Purpose: To evaluate the role of serum urea and creatinine as surrogate markers for disruption of retinal photoreceptor external limiting membrane (ELM) and inner segment ellipsoid zone (EZ) in Type 2 diabetic retinopathy (DR) using spectral-domain optical coherence tomography, for the first time.

    Methods: One hundred and seventeen consecutive cases of Type 2 diabetes mellitus (diabetes without retinopathy [No DR; n = 39], nonproliferative diabetic retinopathy [NPDR; n = 39], proliferative diabetic retinopathy [PDR; n = 39]) and 40 healthy control subjects were included. Serum levels of urea and creatinine were assessed using standard protocol. Read More

    Co-Evaluation of Peripapillary RNFL Thickness and Retinal Thickness in Patients with Diabetic Macular Edema: RNFL Misinterpretation and Its Adjustment.
    PLoS One 2017 23;12(1):e0170341. Epub 2017 Jan 23.
    Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, South Korea.
    We investigated the relationship between the peripapillary retinal nerve fiber layer and peripapillary retinal thickness in patients with diabetic macular edema. Fifty eyes (group I) with non-proliferative diabetic retinopathy and diabetic macular edema receiving intravitreal anti-VEGF injection, and 90 eyes (group II) without diabetic macular edema were included in this case-control study. The peripapillary retinal nerve fiber layer thickness, peripapillary retinal thickness, and a new retinal nerve fiber layer index using a modeled relationship between the two parameters were evaluated with spectral-domain optical coherence tomography, at baseline and at the 6-month follow-up. Read More

    Plasma microRNA-21 expression: an indicator for the severity of type 2 diabetes with diabetic retinopathy.
    Biosci Rep 2017 Jan 20. Epub 2017 Jan 20.
    Department of Ophthalmology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, China
    Objective: To investigate the roles of plasma microRNA-21 (miR-21) in the pathogenic process of type 2 diabetes (T2D) with diabetic retinopathy (DR).

    Methods: T2D patients included patients without DR (NDR group), patients with non-proliferative/background DR (BDR group) and patients with proliferative DR (PDR group). Healthy individuals served as control group. Read More

    Mini Review: Changes in the Incidence of and Progression to Proliferative and Sight-Threatening Diabetic Retinopathy Over the Last 30 Years.
    Ophthalmic Epidemiol 2017 Jan 19:1-8. Epub 2017 Jan 19.
    c Save Sight Institute , University of Sydney , Sydney , Australia.
    Purpose: Diabetic retinopathy is a leading cause of blindness worldwide. The last 3 decades have seen major improvements in glycemic and blood pressure control as well as the introduction of national screening programs, and we sought to determine if rates of proliferative diabetic retinopathy have changed as a result.

    Methods: We conducted a systematic review to determine whether the incidence and progression rates of proliferative diabetic retinopathy and sight-threatening retinopathy have changed, focusing on large population-based studies with objective assessment of diabetic retinopathy. Read More

    Prediction of risk of diabetic retinopathy for all-cause mortality, stroke and heart failure: Evidence from epidemiological observational studies.
    Medicine (Baltimore) 2017 Jan;96(3):e5894
    aDepartment of Endocrinology bDepartment of Ophthalmology, Beijing Tongren Hospital, Capital Medical University cDepartment of Geratology, Beijing Haidian Hospital dBeijing Key Laboratory of Diabetes Research and Care, Beijing China.
    To examine and quantify the potential relation between diabetic retinopathy (DR) and risk of all-cause mortality, stroke and heart failure (HF).The resources of meta-analysis of epidemiological observational studies were from Pub-med, EMBASE, CINAHL, Cochrane Library, conference, and proceedings.Random/fixed effects models were used to calculate pooled subgroup analysis stratified by different grades of DR was performed to explore the potential source of heterogeneity. Read More

    PERSISTENT OVERPRODUCTION OF INTRAOCULAR VASCULAR ENDOTHELIAL GROWTH FACTOR AS A CAUSE OF LATE VITREOUS HEMORRHAGE AFTER VITRECTOMY FOR PROLIFERATIVE DIABETIC RETINOPATHY.
    Retina 2017 Jan 16. Epub 2017 Jan 16.
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
    Purpose: The purpose of this study was to investigate whether vitreous levels of vascular endothelial growth factor (VEGF) predict late vitreous hemorrhage (VH) after vitrectomy for proliferative diabetic retinopathy, and how VEGF level changes in patients with postoperative late VH.

    Methods: Eighty-five eyes of 68 patients with proliferative diabetic retinopathy who underwent vitrectomy were analyzed retrospectively. Vitreous samples were collected from eyes undergoing primary vitrectomy and from eyes with late VH undergoing second vitrectomy. Read More

    ASSESSMENT OF RETINAL BLOOD FLOW IN DIABETIC RETINOPATHY USING DOPPLER FOURIER-DOMAIN OPTICAL COHERENCE TOMOGRAPHY.
    Retina 2017 Jan 16. Epub 2017 Jan 16.
    *Doppler OCT Reading Center, Doheny Eye Institute, Los Angeles, California; †Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; ‡Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, Oklahoma; §Department of Ophthalmology, Northwestern University, Chicago, Illinois; and ¶Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.
    Purpose: To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT).

    Methods: Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Read More

    Refractive aim and visual outcome after phacoemulsification: A 2-year review from a Tertiary Private Eye Hospital in Sub-Saharan Africa.
    Niger J Clin Pract 2017 Feb;20(2):147-152
    Anterior Segment and Cataract Unit, Eye Foundation Hospital, Lagos, Nigeria.
    Aim: To review the short-term visual outcome of phacoemulsification in adults with uncomplicated cataracts in Eye Foundation Hospital, Lagos, Nigeria.

    Materials And Methods: A retrospective review of records of patients that had phacoemulsification between January 2012 and December 2013 in Eye Foundation Hospital, Lagos, Nigeria, was done. Preoperative visual acuity, refractive aim, intraoperative complications, postoperative unaided, and best-corrected visual acuity at 1 and 3 months were analyzed. Read More

    Elevated Levels of Plasma IgA Autoantibodies against Oxidized LDL Found in Proliferative Diabetic Retinopathy but Not in Nonproliferative Retinopathy.
    J Diabetes Res 2016 20;2016:2614153. Epub 2016 Dec 20.
    PEDEGO Research Unit, Department of Ophthalmology, Medical Research Center (MRC Oulu), Oulu University Hospital and University of Oulu, Oulu, Finland; Research Unit of Internal Medicine, Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and University of Oulu, Oulu, Finland.
    Aims. This study investigated the association of autoantibodies binding to oxidized low-density lipoproteins (oxLDL) in diabetic retinopathy (DR). Methods. Read More

    Efficacy of 0.2 μg/day fluocinolone acetonide implant (ILUVIEN) in eyes with diabetic macular edema and prior vitrectomy.
    Eye (Lond) 2017 Jan 13. Epub 2017 Jan 13.
    Department of Ophthalmology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany.
    PurposeLimited data are available on the efficacy of the 0.2 μg/day fluocinolone acetonide (FAc) implant in eyes with prior vitrectomy. Here, we present a collection of 26 vitrectomized eyes treated with the 0. Read More

    Inflammation and N-formyl peptide receptors mediate the angiogenic activity of human vitreous humour in proliferative diabetic retinopathy.
    Diabetologia 2017 Jan 13. Epub 2017 Jan 13.
    Department of Molecular and Translational Medicine, University of Brescia, Via Branze 39, Brescia, 25123, Italy.
    Aims/hypothesis: Angiogenesis and inflammation characterise proliferative diabetic retinopathy (PDR), a major complication of diabetes mellitus. However, the impact of inflammation on the pathogenesis of PDR neovascularisation has not been elucidated. Here, we assessed the capacity of PDR vitreous fluid to induce pro-angiogenic/proinflammatory responses in endothelium and the contribution of the inflammation-related pattern recognition N-formyl peptide receptors (FPRs) in mediating these responses. Read More

    Long-term Effects of Intravitreal 0.19 mg Fluocinolone Acetonide Implant on Progression and Regression of Diabetic Retinopathy.
    Ophthalmology 2017 Jan 9. Epub 2017 Jan 9.
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
    Objective: To investigate the effects of fluocinolone acetonide (FAc) on the progression to proliferative diabetic retinopathy (PDR) and the impact of FAc on changes in Early Treatment Diabetic Retinopathy Study (ETDRS) diabetic retinopathy (DR) severity scale (DRSS) grade during the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) A and B Phase III clinical trials.

    Design: Post hoc analysis of data from the 36-month prospective, randomized, FAME A and B trials.

    Participants: Patients with diabetic macular edema (DME) who received sham control or FAc 0. Read More

    Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy.
    J Clin Lab Anal 2017 Jan 12. Epub 2017 Jan 12.
    Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, China.
    Objective: Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR).

    Methods: This study was performed in a population of 189 diabetic patients and 48 control subjects. Read More

    Profiles of Inflammatory Cytokines in the Vitreous Fluid from Patients with Rhegmatogenous Retinal Detachment and Their Correlations with Clinical Features.
    Biomed Res Int 2016 15;2016:4256183. Epub 2016 Dec 15.
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
    Purpose. To characterize the profiles for inflammatory cytokines in the vitreous fluid from patients with rhegmatogenous retinal detachment (RRD) by comparing those of other vitreoretinal diseases and to analyze the correlation between intravitreal cytokines and clinical features. Materials and Methods. Read More

    The Prevention and Treatment of Retinal Complications in Diabetes.
    Dtsch Arztebl Int 2016 Dec;113(48):816-823
    German Agency for Quality in Medicine (ÄZQ), Berlin.
    Background: Microvascular complications of diabetes mellitus can cause retino pathy and maculopathy, which can irreversibly damage vision and lead to blindness. The prevalence of retinopathy is 9-16% in patients with type 2 diabetes and 24-27% in patients with type 1 diabetes. 0. Read More

    Absence of macrophage migration inhibitory factor reduces proliferative retinopathy in a mouse model.
    Acta Diabetol 2017 Jan 9. Epub 2017 Jan 9.
    5th Medical Department, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
    Aims: Ischemia-induced neovascularization is the key feature of proliferative diabetic retinopathy. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory and proangiogenic cytokine, and its levels are elevated in the vitreous of patients with proliferative diabetic retinopathy. In this study, we aimed at investigating the relative potential of MIF in the ischemia-induced retinal neovascularization. Read More

    Prevalence of diabetic retinopathy among 13473 patients with diabetes mellitus in China: a cross-sectional epidemiological survey in six provinces.
    BMJ Open 2017 Jan 9;7(1):e013199. Epub 2017 Jan 9.
    Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
    Objective: To describe the prevalence and severity of diabetic retinopathy (DR) and sight-threatening DR (STDR) among Chinese adults with diabetes.

    Design, Setting And Participants: A cross-sectional epidemiological survey across Mainland China (N=13 473). Participants were diagnosed with diabetes mellitus by physicians and transferred to our screening clinics (1/3 from hospital patients, 1/3 from city residents, the other 1/3 from rural residents). Read More

    Vitrectomy for complications of proliferative diabetic retinopathy in young adults: clinical features and surgical outcomes.
    Graefes Arch Clin Exp Ophthalmol 2017 Jan 6. Epub 2017 Jan 6.
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
    Purpose: To investigate the clinical manifestations and surgical results after vitrectomy for proliferative diabetic retinopathy (PDR) in young patients.

    Methods: Clinical features of patients between 18 to 40 years old who received vitrectomy for PDR between January 2009 and January 2015 were retrospectively reviewed. Those older than 40 years who received vitrectomy for PDR during the same period were retrospectively enrolled and compared as the control group. Read More

    The Efficacy of Intravitreal Bevacizumab in Vitreous Hemorrhage of Diabetic Subjects.
    Turk J Ophthalmol 2016 Oct 17;46(5):221-225. Epub 2016 Oct 17.
    Beyoğlu Eye Training and Research Hospital, İstanbul, Turkey.
    Objectives: To evaluate the efficacy of intravitreal bevacizumab (IVB) in the resolution of vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR).

    Materials And Methods: Seventy eyes of 70 patients (43 male, mean age 55.6±12. Read More

    VEGF, the underlying factor for metabolic syndrome; fact or fiction?
    Diabetes Metab Syndr 2016 Dec 9. Epub 2016 Dec 9.
    UMR INSERM U 1122, IGE-PCV "Interactions Gène-Environnement en Physiopathologie CardioVasculaire ", Université de Lorraine, Nancy, France.
    Metabolic syndrome (MetS) is currently diagnosed by the co-presence of at least three of the five following abnormalities: abdominal obesity, dysglycaemia, elevated serum triglycerides, low high-density cholesterol (HDL) and finally elevated blood pressure. Metabolic syndrome increases the risk of developing cardiovascular disease and diabetes. This review is on the associations between MetS and vascular endothelial growth factor (VEGF). Read More

    Association between microfibrillar-associated protein 4 (MFAP4) and micro- and macrovascular complications in long-term type 1 diabetes mellitus.
    Acta Diabetol 2016 Dec 30. Epub 2016 Dec 30.
    Department of Ophthalmology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.
    Aims: To evaluate microfibrillar-associated protein 4 (MFAP4) as a marker of micro- and macrovascular complications in patients with type 1 diabetes.

    Methods: This cross-sectional study included 203 persons with a long duration of type 1 diabetes from a population-based cohort ascertained in the former Funen County, Denmark. Detection of plasma-MFAP4 (pMFAP4) was performed by the AlphaLISA Technique. Read More

    Periodontitis is associated with diabetic retinopathy in non-obese adults.
    Endocrine 2016 Dec 28. Epub 2016 Dec 28.
    Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    Purpose: Patients with diabetes retinopathy appear to show increased susceptibility to periodontal disease. This study was performed to assess the relationship between periodontitis and the prevalence of diabetic retinopathy in a large probability sample of the Korean population. A subgroup analysis was performed using body mass index <25 kg/m(2) as the criterion to evaluate the effect of obesity on this relationship. Read More

    Automated Diabetic Retinopathy Image Assessment Software: Diagnostic Accuracy and Cost-Effectiveness Compared with Human Graders.
    Ophthalmology 2017 Mar 23;124(3):343-351. Epub 2016 Dec 23.
    Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, United Kingdom.
    Objective: With the increasing prevalence of diabetes, annual screening for diabetic retinopathy (DR) by expert human grading of retinal images is challenging. Automated DR image assessment systems (ARIAS) may provide clinically effective and cost-effective detection of retinopathy. We aimed to determine whether ARIAS can be safely introduced into DR screening pathways to replace human graders. Read More

    Ocular pulse amplitude after panretinal photocoagulation in normotensive eyes with proliferative diabetic retinopathy.
    Eur J Ophthalmol 2016 Nov 28. Epub 2016 Nov 28.
    University Eye Hospital, Belgrade - Serbia.
    Purpose: To assess the effect of panretinal laser photocoagulation on ocular pulse amplitude (OPA) in normotensive eyes with proliferative diabetic retinopathy.

    Methods: Prospectively, we performed unilateral argon laser panretinal photocoagulation (PRP) in 30 patients with diabetes mellitus type II and previously untreated bilateral proliferative diabetic retinopathy. Before and 7 and 30 days after the treatment, OPA was measured using dynamic contour tonometer. Read More

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