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    Statins and Fibrates for Diabetic Retinopathy: Protocol for a Systematic Review.
    JMIR Res Protoc 2017 Feb 22;6(2):e30. Epub 2017 Feb 22.
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
    Background: Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus, and more than 75% of patients who have had diabetes for more than 20 years will have some degree of DR. This disease is highly destructive to self-esteem and puts a high burden on public health and pension systems due to the effects that it has on people of working age. The current mainstay of treatment is laser photocoagulation, which causes impairment of vision and discomfort to patients. Read More

    Deep neural ensemble for retinal vessel segmentation in fundus images towards achieving label-free angiography.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:1340-1343
    Automated segmentation of retinal blood vessels in label-free fundus images entails a pivotal role in computed aided diagnosis of ophthalmic pathologies, viz., diabetic retinopathy, hypertensive disorders and cardiovascular diseases. The challenge remains active in medical image analysis research due to varied distribution of blood vessels, which manifest variations in their dimensions of physical appearance against a noisy background. Read More

    What do patients with diabetes and providers think of an innovative Australian model of remote diabetic retinopathy screening? A qualitative study.
    BMC Health Serv Res 2017 Feb 22;17(1):158. Epub 2017 Feb 22.
    Discipline of General Practice, University of Queensland, Royal Brisbane Hospital, Level 8 Health Sciences Building, Herston, QLD, 4029, Australia.
    Background: Diabetic retinopathy (DR) is the commonest cause of preventable blindness in working age populations, but up to 98% of visual loss secondary to DR can be prevented with early detection and treatment. In 2012, an innovative outreach DR screening model was implemented in remote communities in a state of Australia. The aim of this study was to explore the acceptability of this unique DR screening model to patients, health professionals and other key stakeholders. Read More

    Blocking IL-17A Alleviates Diabetic Retinopathy in Rodents.
    Cell Physiol Biochem 2017 Feb 21;41(3):960-972. Epub 2017 Feb 21.
    Background/aims: Interleukin (IL)-17A, a proinflammatory cytokine, has been implicated in several autoimmune diseases. However, it is unclear whether IL-17A is involved in diabetic retinopathy (DR), one of the most serious complications of autoimmune diabetes. This study aimed to demonstrate that IL-17A exacerbates DR by affecting retinal Müller cell function. Read More

    A low prevalence of non alcoholic fatty liver disease in patients with type 1 diabetes is associated to decreased subclinical cardiovascular disease.
    J Diabetes 2017 Feb 20. Epub 2017 Feb 20.
    Service of Endocrinology and Nutrition, Department of Medicine, Institute of Research and Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERDEM and CIBERER, Instituto de Salud Carlos III, Spain.
    Background: Non-alcoholic fatty liver disease (NAFLD) has been proposed as an independent cardiovascular risk factor. This study evaluated the prevalence of NAFLD in a cohort of Type 1 Diabetic (T1D) patients and its potential relationship with subclinical cardiovascular disease (CVD).

    Methods: Cross-sectional study in which 100 T1D patients (39. Read More

    Pseudophakic cystoid macular edema prevention and risk factors; prospective study with adjunctive once daily topical nepafenac 0.3% versus placebo.
    BMC Ophthalmol 2017 Feb 20;17(1):16. Epub 2017 Feb 20.
    Arizona Eye Consultants, 355 N. Silverbell Ave, Tucson, AZ, 85745, USA.
    Background: Define the effectiveness of a topical non-steroidal anti-inflammatory drug (NSAID) added to topical steroid use after uncomplicated phacoemulsification for the prevention of pseudophakic cystoid macular edema (PCME) using a prospective, randomized, double-masked, placebo-controlled clinical study.

    Methods: Eyes (1000) were randomized to placebo (497) or nepafenac 0.3% (503) used once daily, post-operatively for 5 weeks at two ophthalmology clinics. Read More

    Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients.
    Cardiovasc Diabetol 2017 Feb 15;16(1):24. Epub 2017 Feb 15.
    INSERM U-1088, Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications, 80025, Amiens, France.
    Background: Vascular calcification (VC) is common in type 2 diabetes, and is associated with cardiovascular complications. Recent preclinical data suggest that metformin inhibits VC both in vitro and in animal models. However, metformin's effects in patients with diabetic VC have not previously been characterized. Read More

    Efficacy of the Intravitreal Sustained-Release Dexamethasone Implant for Diabetic Macular Edema Refractory to Anti-Vascular Endothelial Growth Factor Therapy: Meta-Analysis and Clinical Implications.
    Ophthalmic Surg Lasers Imaging Retina 2017 Feb;48(2):160-166
    Background And Objective: To assess the effect on best-corrected visual acuity (BCVA) and efficacy of the intravitreal sustained-release 0.7 mg dexamethasone implant (Ozurdex; Allergan, Irvine, CA) in patients with recalcitrant diabetic macular edema (DME).

    Patients And Methods: Meta-analysis utilizing the MOOSE framework and a random effects model. Read More

    [Indications for Retinal Laser Therapy Revisited].
    Klin Monbl Augenheilkd 2017 Feb 10. Epub 2017 Feb 10.
    Zentrum für Augenheilkunde, Universität zu Köln.
    Background Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications for the use of laser treatment need to be reviewed carefully, especially with respect to their significance in first line therapy. Read More

    The A445C Variant in Apelin Receptor and Diabetic Retinopathy in Tunisian Patients.
    Clin Lab 2017 Feb;63(2):379-383
    Background: Apelin and apelin receptor (APLN/APLNR) are involved in the retinal neovascularization of diabetic retinopathy (DR).

    Methods: This study investigated the impact of the APLNR A445C variant on the risk of DR in a sample of the Tunisian population (100 patients with DR and 105 healthy controls) using PCR-RFLP.

    Results: The genotype frequencies of the APLNR A445C variant were not significantly different between the patient and control groups. Read More

    Circulating monocytes and B-lymphocytes in neovascular age-related macular degeneration.
    Clin Ophthalmol 2017 17;11:179-184. Epub 2017 Jan 17.
    Clinical Eye Research Unit, Zealand University Hospital, Roskilde; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Background: Individuals with neovascular age-related macular degeneration (AMD) have altered number and distribution of retinal macrophages and show changes in circulating antibodies. We wanted to investigate the corresponding precursors, with subpopulations. We therefore measured monocyte and B-lymphocyte populations in individuals with neovascular AMD. Read More

    Auckland Cataract Study 2: clinical outcomes of phacoemulsification cataract surgery in a public teaching hospital.
    Clin Exp Ophthalmol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Science, University of Auckland, Auckland, New Zealand.
    Importance: A contemporary benchmark for the most common ophthalmic surgery.

    Background: To assess patient characteristics and outcomes of contemporary phacoemulsification cataract surgery in a New Zealand public teaching hospital setting.

    Design: Prospective observational study. Read More

    [The protective effect of human umbilical cord mesenchymal stem cells-induced neural stem cells in the vitreous on the blood-retinal barrier in diabetic rats].
    Zhonghua Yan Ke Za Zhi 2017 Jan;53(1):53-58
    Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science, Tianjin Institute of Ophthalmology, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin 300020, China.
    Objective: To investigate the effect of intravitreal injection of neural stem cells (NSC) induced from human umbilical cord mesenchymal stem cells, and to provide a theoretical basis for the clinical treatment of blood-retinal barrier damage due to diabetic retinopathy (DR). Methods: Experimental study. Sixty male Sprague-Dawley rats were randomly divided into control group, DR group and NSC group. Read More

    Membranous nephropathy occurring with type 2 diabetes mellitus
.
    Clin Nephrol 2017 Mar;87 (2017)(3):140-146
    Background: The incidence of type 2 diabetes mellitus (T2DM) is increasing, and membranous nephropathy (MN) occurs frequently with T2DM. We investigated the clinicopathological features and outcomes of patients with T2DM and MN.

    Methods: A total of 137 patients with biopsy-proven MN and T2DM were enrolled in this retrospective study. Read More

    Role of oxidative stress in epigenetic modification of MMP-9 promoter in the development of diabetic retinopathy.
    Graefes Arch Clin Exp Ophthalmol 2017 Jan 25. Epub 2017 Jan 25.
    Kresge Eye Institute, Wayne State University, Detroit, MI, 48201, USA.
    Background: In the pathogenesis of diabetic retinopathy, damaged retinal mitochondria accelerate apoptosis of retinal capillary cells, and regulation of oxidative stress by manipulating mitochondrial superoxide dismutase (SOD2) protects mitochondrial homeostasis and prevents the development of diabetic retinopathy. Diabetes also activates matrix metalloproteinase-9 (MMP-9), and activated MMP-9 damages retinal mitochondria. Recent studies have shown a dynamic DNA methylation process playing an important role in regulation of retinal MMP-9 transcription in diabetes; the aim of this study is to investigate the role of oxidative stress in MMP-9 transcription. Read More

    Progranulin, a new adipokine at the crossroads of metabolic syndrome, diabetes, dyslipidemia and hypertension.
    Curr Pharm Des 2017 Jan 24. Epub 2017 Jan 24.
    Department of Pathophysiology, Medical University, Lublin, Poland.
    Background: Progranulin is a multifunctional regulatory protein with growth-promoting, neuroprotective and antiinflammatory activities. Recent studies indicate that progranulin is one of the adipose tissue hormones (adipokines). Progranulin expression in visceral adipose tissue and circulating progranulin concentration are increased in obesity and hyperprogranulinemia is involved in the pathogenesis of obesity-associated insulin resistance. Read More

    Blood pressure regulation determined by ambulatory blood pressure profiles in children and adolescents with type 1 diabetes mellitus: Impact on diabetic complications.
    Pediatr Diabetes 2017 Jan 24. Epub 2017 Jan 24.
    Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.
    Background: The combination of high blood pressure and hyperglycemia contributes to the development of diabetic complications. Ambulatory monitoring of blood pressure (ABPM) is seen as standard to assess blood pressure (BP) regulation.

    Objective: We evaluated 24-hour BP regulation in 3529 children with type 1 diabetes, representing 5. Read More

    Detection of exudates in fundus photographs using deep neural networks and anatomical landmark detection fusion.
    Comput Methods Programs Biomed 2016 Dec 6;137:281-292. Epub 2016 Oct 6.
    Faculty of Electrical Engineering and Computing, University of Zagreb, Unska 3, 10000 Zagreb, Croatia.
    Background And Objective: Diabetic retinopathy is one of the leading disabling chronic diseases and one of the leading causes of preventable blindness in developed world. Early diagnosis of diabetic retinopathy enables timely treatment and in order to achieve it a major effort will have to be invested into automated population screening programs. Detection of exudates in color fundus photographs is very important for early diagnosis of diabetic retinopathy. Read More

    Plasma microRNA-21 expression: an indicator for the severity of type 2 diabetes with diabetic retinopathy.
    Biosci Rep 2017 Jan 20. Epub 2017 Jan 20.
    Department of Ophthalmology, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, China
    Objective: To investigate the roles of plasma microRNA-21 (miR-21) in the pathogenic process of type 2 diabetes (T2D) with diabetic retinopathy (DR).

    Methods: T2D patients included patients without DR (NDR group), patients with non-proliferative/background DR (BDR group) and patients with proliferative DR (PDR group). Healthy individuals served as control group. Read More

    Bariatric surgery and diabetic retinopathy: a systematic review and meta-analysis of controlled clinical studies.
    Obes Rev 2017 Mar 13;18(3):309-316. Epub 2017 Jan 13.
    Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.
    Background: Uncontrolled studies have indicated appearance or progression of diabetic retinopathy in obese diabetic patients after bariatric surgery. The aim of this systematic review and meta-analysis was to compare the rate of appearance, as well as progression or regression of diabetic retinopathy in studies comparing medical and surgical treatment of obese type 2 diabetes.

    Methods And Findings: Intervention effect (new cases of retinopathy, and cases with any change of diabetic retinopathy score) was expressed as odds ratio (OR), with 95% confidence intervals (CIs); change of diabetic retinopathy score was expressed as standardized mean difference (SMD), with 95% CIs. Read More

    The potential of spectral domain optical coherence tomography imaging based retinal biomarkers.
    Int J Retina Vitreous 2017 9;3. Epub 2017 Jan 9.
    Harvard Medical School, Massachusetts Eye and Ear, Boston, MA USA.
    Background: Biomarker", a merged word of "biological marker", refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases. Read More

    The Prevention and Treatment of Retinal Complications in Diabetes.
    Dtsch Arztebl Int 2016 Dec;113(48):816-823
    German Agency for Quality in Medicine (ÄZQ), Berlin.
    Background: Microvascular complications of diabetes mellitus can cause retino pathy and maculopathy, which can irreversibly damage vision and lead to blindness. The prevalence of retinopathy is 9-16% in patients with type 2 diabetes and 24-27% in patients with type 1 diabetes. 0. Read More

    Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy.
    Cardiovasc Diabetol 2017 Jan 7;16(1). Epub 2017 Jan 7.
    Department of Ophthalmology, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon, 16499, South Korea.
    Background: To investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes.

    Methods: The medical records of 110 patients with type 2 diabetes (70 statin users and 40 non-users) were retrospectively reviewed. The two outcome measures were progression of diabetic retinopathy by two or more steps on the early treatment diabetic retinopathy study scale and diabetic macular edema based on optical coherence tomography. Read More

    Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy.
    J Diabetes Res 2016 13;2016:7592402. Epub 2016 Dec 13.
    University of Health Sciences Antalya Training and Research Hospital, Department of Internal Medicine, Antalya, Turkey.
    Background and Objectives. Nailfold capillaroscopy is an easy and noninvasive technique used to investigate dermal microvasculature. Traditional investigations of vascularity do not detect changes until they are well-established in type 2 diabetics. Read More

    Prevalent Rate of Nonalbuminuric Renal Insufficiency and Its Association with Cardiovascular Disease Event in Korean Type 2 Diabetes.
    Endocrinol Metab (Seoul) 2016 Dec;31(4):577-585
    Department of Internal Medicine, Pusan National University School of Medicine and Diabetes Center, Pusan National University Yangsan Hospital, Yangsan, Korea.
    Background: Nonalbuminuric renal insufficiency is a unique category of diabetic kidney diseases. The objectives of the study were to evaluate prevalent rate of nonalbuminuric renal insufficiency and to investigate its relationship with previous cardiovascular disease (CVD) event in Korean patients with type 2 diabetes mellitus (T2DM).

    Methods: Laboratory and clinical data of 1,067 subjects with T2DM were obtained and reviewed. Read More

    Changes in Quality of Diabetes Care and Morbidity over 20 Years in People with Type 1 Diabetes and Long Diabetes Duration: The JEVIN Trial.
    Exp Clin Endocrinol Diabetes 2016 Dec 22. Epub 2016 Dec 22.
    Department of Internal Medicine III, University Hospital Jena, Jena, Germany.
    Background: The JEVIN trial started as a cross-sectional study in 1989/90 in Jena, a city of the former German Democratic Republic. At that time, the centralized diabetes care system was broken down and restarted 10 years later; structured treatment and teaching programs were implemented, blood glucose self-monitoring, insulin pump-systems and analogue insulin were introduced. We surveyed people with type-1-diabetes of the baseline JEVIN trial in a 20-year follow-up. Read More

    Retinopathy predicts progression of fasting plasma glucose: An Early Diabetes Intervention Program (EDIP) analysis.
    J Diabetes Complications 2016 Nov 12. Epub 2016 Nov 12.
    Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
    Background: Retinopathy is increasingly recognized in prediabetic populations, and may herald increased risk of metabolic worsening. The Early Diabetes Intervention Program (EDIP) evaluated worsening of glycemia in screen-detected Type 2 diabetes, following participants for up to 5years. Here we have evaluated whether the presence of retinopathy at the time of detection of diabetes was associated with accelerated progression of glycemia. Read More

    DIABSAT Telemedicine Itinerant Screening of Chronic Complications of Diabetes Using a Satellite.
    Telemed J E Health 2016 Dec 21. Epub 2016 Dec 21.
    1 Department of Diabetology, University Hospital of Toulouse , Toulouse, France .
    Background: Health authorities recommend regular screening for the chronic complications of diabetes. The ENTRED (*) survey results show that insufficient screening is undertaken. The DIABSAT (†) program aims to improve care for diabetes patients in rural areas of the Midi-Pyrénées region, telemonitoring complications of diabetes through an itinerant screening service. Read More

    Blocking Mammalian Target of Rapamycin (mTOR) Attenuates HIF-1α Pathways Engaged-Vascular Endothelial Growth Factor (VEGF) in Diabetic Retinopathy.
    Cell Physiol Biochem 2016 21;40(6):1570-1577. Epub 2016 Dec 21.
    Department of Ophthalmology, General Hospital of Jinan Military Command, Jinan, China.
    Background/aims: Prior studies demonstrate that hypoxia inducible factor subtype 1α (HIF-1α) in retinal tissues is involved in development of diabetic retinopathy (DR). In this report, we particularly examined the role played by mammalian target of rapamycin (mTOR) in regulating expression of HIF-1α and its downstream pathway, namely vascular endothelial growth factor (VEGF).

    Methods: Streptozotocin (STZ) was systemically injected to induce hyperglycemia in rats. Read More

    Diabetes microvascular complications-A clinical update.
    Diabetes Metab Syndr 2016 Dec 13. Epub 2016 Dec 13.
    Monash University, Monash Rural Health, Moe, Victoria, 3825, Australia. Electronic address:
    Background: The purpose of this study is to summarise the empirical evidence addressing diabetes microvascular complications and management. The effects of diabetes mellitus include long-term damage, dysfunction and failure of various organs. Microvascular disease tends to occur predominantly in tissues where glucose uptake is independent of insulin activity because these tissues are exposed to glucose levels that correlate very closely with blood glucose levels. Read More

    A Case of Proliferative Diabetic Retinopathy with HIV Infection in Which HAART Possibly Influenced the Prognosis of Visual Function.
    Case Rep Ophthalmol 2016 Sep-Dec;7(3):239-244. Epub 2016 Nov 17.
    Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.
    Background: We report on a patient with proliferative diabetic retinopathy (PDR) and human immunodeficiency virus (HIV) infection who exhibited extremely active PDR followed by a rapid onset of blindness in the right eye. The progression of visual disturbance in the patient's left eye was slowed after starting highly active anti-retroviral therapy (HAART), and vision in that eye was rescued after vitrectomy.

    Case Report: A 72-year-old male developed pneumocystis carinii pneumonia stemming from an HIV infection and began HAART at the Department of Hematology, Osaka Medical College, Takatsuki City, Japan. Read More

    Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy.
    Clin Chim Acta 2016 Oct 28. Epub 2016 Oct 28.
    Department of Diabetic Complications, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan. Electronic address:
    Background: Vascular endothelial growth factor (VEGF) signaling is an important pathway in the development of diabetic retinopathy (DR). A recent report showed that leukocyte cell-derived chemotaxin 2 (LECT2) suppresses the VEGF signaling in endothelial cells. However, the clinical relevance of LECT2 in DR is unknown. Read More

    An observational study to assess if automated diabetic retinopathy image assessment software can replace one or more steps of manual imaging grading and to determine their cost-effectiveness.
    Health Technol Assess 2016 Dec;20(92):1-72
    Population Health Research Institute, St George's, University of London, London, UK.
    Background: Diabetic retinopathy screening in England involves labour-intensive manual grading of retinal images. Automated retinal image analysis systems (ARIASs) may offer an alternative to manual grading.

    Objectives: To determine the screening performance and cost-effectiveness of ARIASs to replace level 1 human graders or pre-screen with ARIASs in the NHS diabetic eye screening programme (DESP). Read More

    Association of diabetic vascular complications with poor sleep complaints.
    Diabetol Metab Syndr 2016 8;8:80. Epub 2016 Dec 8.
    Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tongan Road 66, Heping District, Tianjin, 300070 China.
    Background: Literatures reported that poor sleep complaints were associated with a great deal of health outcomes. However, there are few studies on the association of poor sleep complaints with diabetic vascular complications.

    Methods: Aiming on the association, a cross-sectional survey was conducted among 1220 diabetic patients in this study. Read More

    Anti-vascular endothelial growth factor for choroidal neovascularisation in people with pathological myopia.
    Cochrane Database Syst Rev 2016 12 15;12:CD011160. Epub 2016 Dec 15.
    Department of Gastroenterology, Linyi People's Hospital affiliated to Shandong University, 27 Jie Fang Road, Linyi, Shandong, China, 276000.
    Background: Choroidal neovascularisation (CNV) is a common complication of pathological myopia. Once developed, most eyes with myopic CNV (mCNV) experience a progression to macular atrophy, which leads to irreversible vision loss. Anti-vascular endothelial growth factor (anti-VEGF) therapy is used to treat diseases characterised by neovascularisation and is increasingly used to treat mCNV. Read More

    The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus.
    Turk J Med Sci 2016 Nov 17;46(5):1292-1299. Epub 2016 Nov 17.
    Department of Internal Medicine, Kafkas University, Kars, Turkey.
    Background/aim: Patients with diabetes mellitus have an increased risk of developing micro- and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. Read More

    Correlation of Vascular Endothelial Growth Factor Production with Photochemical Reaction-induced Retinal Edema.
    Chin Med J (Engl) 2016 20th Dec;129(24):2944-2950
    Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080; Shanghai Key Laboratory of Fundus Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
    Background: Retinal edema is the major complication of retinal vein occlusion and diabetic retinopathy; it can damage visual function by influencing macular region. This study was to establish a rat retinal edema model and explore the related VEGF expression and observe the responses to anti-VEGF drugs in this model.

    Methods: A rat retinal edema model was established by inducing photochemical reaction using a 532 nm laser after the intravenous injection of Erythrosin B. Read More

    Morphological differences between optic disc collaterals and neovascularization on optical coherence tomography angiography.
    Graefes Arch Clin Exp Ophthalmol 2016 Dec 9. Epub 2016 Dec 9.
    Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, 160012, India.
    Background: To study morphological features of optic disc venous collaterals (OVCs) and neovascularization of optic disc (NVD) on optical coherence tomography angiography (OCTA).

    Methods: Patients with OVCs and NVDs secondary to ischemic retinal diseases were prospectively enrolled. Multimodal imaging was performed using color fundus photography, fluorescein angiography (FA), and OCTA. Read More

    The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy.
    PLoS One 2016 12;11(12):e0167853. Epub 2016 Dec 12.
    5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.
    Background/aims: Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control in type 2 diabetes, however, their influence on the retinal neurovascular unit remains unclear.

    Methods: Vasculo- and neuroprotective effects were assessed in experimental diabetic retinopathy and high glucose-cultivated C. elegans, respectively. Read More

    Elevated plasma levels of copeptin linked to diabetic retinopathy in type 2 diabetes.
    Mol Cell Endocrinol 2017 Feb 8;442:106-112. Epub 2016 Dec 8.
    Department of Ophthalmology, The Second Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
    Background: The arginine vasopressin (AVP) system has been postulated to play a role in glucose homeostasis, insulin resistance, and diabetes mellitus in human and animal studies. The aim of this study was to evaluate the role of plasma copeptin in Chinese patients with type 2 diabetes mellitus (T2DM) with and without diabetic retinopathy (DR).

    Method: Plasma copeptin concentrations were determined in 281 patients with T2DM. Read More

    Epidemiology of diabetic kidney disease in adult patients with type 1 diabetes in Italy: The AMD-Annals initiative.
    Diabetes Metab Res Rev 2016 Dec 9. Epub 2016 Dec 9.
    Department of Medical Sciences, Scientific Institute "Casa Sollievo della Sofferenza", San Giovanni Rotondo (FG), Italy.
    Background: Patients with type 1 diabetes mellitus are at increased risk of death. This risk appears to be modulated by kidney dysfunction. The aim of this study was to evaluate the prevalence of diabetic kidney disease (DKD), its traits, and clinical correlates in a large sample of patients with type 1 diabetes. Read More

    miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling.
    J Neuroinflammation 2016 Dec 8;13(1):305. Epub 2016 Dec 8.
    Department of Anatomy and Cell Biology, Wayne State University, 9314 Scott Hall, Detroit, MI, 48202, USA.
    Background: Hyperglycemia is a significant risk factor for diabetic retinopathy and induces increased inflammatory responses and retinal leukostasis, as well as vascular damage. Although there is an increasing amount of evidence that miRNA may be involved in the regulation in the pathology of diabetic retinopathy, the mechanisms by which miRNA mediate cellular responses to control onset and progression of diabetic retinopathy are still unclear. The purpose of our study was to investigate the hypothesis that miR-15a/16 inhibit pro-inflammatory signaling to reduce retinal leukostasis. Read More

    Self-care tools to treat depressive symptoms in patients with age-related eye disease: a randomized controlled clinical trial.
    Clin Exp Ophthalmol 2016 Dec 7. Epub 2016 Dec 7.
    Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
    Background: Depression is very common in people with age-related eye disease. Our goal was to determine if self-care tools plus limited telephone support could reduce depressive symptoms in patients with age-related macular degeneration or diabetic retinopathy.

    Design: A single-blind randomized controlled clinical trial was conducted at Maisonneuve-Rosemont Hospital in Montreal, Canada. Read More

    Increased levels of alphaB-crystallin in vitreous fluid of patients with proliferative diabetic retinopathy and correlation with vascular endothelial growth factor.
    Clin Exp Ophthalmol 2016 Dec 7. Epub 2016 Dec 7.
    Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
    Background: AlphaB-crystallin has been shown to have angiogenic properties. The purpose of this study was to determine the levels of alphaB-crystallin in the vitreous fluid of patients with proliferative diabetic retinopathy and to confirm the association between the expression level of alphaB-crystallin and vascular endothelial growth factor.

    Methods: Vitreous samples were collected before vitrectomy from 46 eyes of 46 consecutive patients with proliferative diabetic retinopathy, and 19 patients without diabetes mellitus had vitrectomy for idiopathic macular hole. Read More

    Colour Doppler analysis of ophthalmic vessels in the diagnosis of carotic artery and retinal vein occlusion, diabetic retinopathy and glaucoma: systematic review of test accuracy studies.
    BMC Ophthalmol 2016 Dec 7;16(1):214. Epub 2016 Dec 7.
    Eye Clinic, Cantonal Hospital of Lucerne, Spitalstrasse, CH-6001, Lucerne, Switzerland.
    Background: Colour Doppler analysis of ophthalmic vessels has been proposed as a promising tool in the diagnosis of various eye diseases, but the available diagnostic evidence has not yet been assessed systematically. We performed a comprehensive systematic review of the literature on the diagnostic properties of Colour Doppler imaging (CDI) assessing ophthalmic vessels and provide an inventory of the available evidence.

    Methods: Eligible papers were searched electronically in (Pre) Medline, Embase and Scopus, and via cross-checking of reference lists. Read More

    A study on the association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes mellitus.
    J Nephropathol 2016 Oct 26;5(4):139-143. Epub 2016 Jul 26.
    Students Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
    Background: Diabetic dermopathy is one of the most prevalent skin complications in diabetes patients. Some studies have pointed to association of diabetic dermopathy with retinopathy and nephropathy in patients with type 2 diabetes as microangiopathy presentations, but no rigorous study has been conducted to confirm this association.

    Objectives: This study investigated association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes referring specialty clinic of Shahrekord. Read More

    Bariatric surgery is associated with less progression of diabetic retinopathy: A systematic review and meta-analysis.
    Surg Obes Relat Dis 2016 Oct 5. Epub 2016 Oct 5.
    Department of Ophthalmology, Soonchunhyang University College of Medicine, Soonchunhyang University Seoul Hospital, Seoul, South Korea. Electronic address:
    Background: The impact of bariatric surgery on diabetic retinopathy (DR) remains underexplored, and conflicting results have been reported.

    Objective: To clarify the impact of bariatric surgery on DR.

    Setting: A systematic review and meta-analysis. Read More

    Incidence of complications in young-onset diabetes: Comparing type 2 with type 1 (the young diab study).
    Diabetes Res Clin Pract 2017 Jan 17;123:1-8. Epub 2016 Nov 17.
    Emory Global Diabetes Research Center, Rollins School of Public Health, Emory University, Atlanta, USA.
    Background: There is little data on the incidence of diabetes complications in young onset type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in non European populations.

    Methods: From a tertiary diabetes centre, Chennai, India, we recruited 108 T1DM (defined by abrupt onset of symptoms or diabetic ketoacidosis, absent insulin reserve requiring insulin treatment) and 90 T2DM participants (defined by absence of ketosis, good beta-cell reserve, and good response to oral agents) who were diagnosed between the ages of 10 and 25years, and without any evidence of diabetes complications at diagnosis. We estimated the incidence of various complications (median follow up of five years); retinopathy was defined by presence of at least one definite microaneurysm by retinal photography, nephropathy by urinary albumin excretion ⩾30μg/mg of creatinine, neuropathy by vibration perception threshold ⩾20V on biothesiometry, peripheral vascular disease by an ankle-brachial index <0. Read More

    Automated System for Referral of Cotton-Wool Spots.
    Curr Diabetes Rev 2016 Dec 1. Epub 2016 Dec 1.
    Department of Electronic Engineering, Faculty of Engineering and Technology, International Islamic University, Islamabad, Pakistan.
    Background: Cotton-wool spots also referred as soft exudates are the early sign of complications in the eye fundus of the patients suffering from diabetic retinopathy. Early detection of exudates helps in diagnosis of the disease and provides better medical attention.

    Methods: In the paper an automated system for detection of soft exudates has been suggested. Read More

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