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    Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy.
    Asia Pac J Clin Nutr 2017 May;26(3):406-411
    School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China. Email:
    Background And Objectives: The purpose of this study was to determine whether supplementation with lutein improved visual function in patients with nonproliferative diabetic retinopathy (NPDR).

    Methods And Study Design: In this randomized, double-blind, placebo-controlled trial, 31 patients with NPDR were assigned randomly to 10 mg/d of lutein or identical placebo for 36 weeks. Visual performance indices, including visual acuity (VA), contrast sensitivity (CS) and glare sensitivity (GS) at four different spatial frequencies, were measured at baseline, week 18 and 36. Read More

    Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes.
    • Authors:
    N Engl J Med 2017 04;376(16):1507-1516
    Background In patients who have had type 1 diabetes for 5 years, current recommendations regarding screening for diabetic retinopathy include annual dilated retinal examinations to detect proliferative retinopathy or clinically significant macular edema, both of which require timely intervention to preserve vision. During 30 years of the Diabetes Control and Complications Trial (DCCT) and its longitudinal follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study, retinal photography was performed at intervals of 6 months to 4 years. Methods We used retinal photographs from the DCCT/EDIC study to develop a rational screening frequency for retinopathy. Read More

    The Association of a Genetic Variant in SCAF8-CNKSR3 with Diabetic Kidney Disease and Diabetic Retinopathy in a Chinese Population.
    J Diabetes Res 2017 19;2017:6542689. Epub 2017 Mar 19.
    National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210016, China.
    Background. Genome-wide association studies found rs955333 located in 6q25.2 was associated with diabetic kidney disease in multiple ethnic populations, including European Americans, African Americans, and Mexican Americans. Read More

    Diabetic nephropathy as the cause of end-stage kidney disease reported on the medical evidence form CMS2728 at a single center.
    Clin Kidney J 2017 Apr 22;10(2):257-262. Epub 2016 Dec 22.
    Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
    Background: End-stage renal disease (ESRD) incidence due to Type 2 diabetic nephropathy (DN) is 35-50%, according to the United States Renal Data System. Methods: A single-center, retrospective cohort study to determine incidence and diagnostic accuracy for Type 2 DN as the primary cause of ESRD (Code 250.40) on the Center for Medicare & Medicaid (CMS) Medical Evidence Report form (CMS2728) submitted at renal replacement therapy initiation. Read More

    Rhodopsin in plasma from patients with diabetic retinopathy - development and validation of digital ELISA by Single Molecule Array (Simoa) technology.
    J Immunol Methods 2017 Apr 5. Epub 2017 Apr 5.
    Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Denmark; Faculty of Health Science, University of Southern Denmark, Odense, Denmark.
    Background: Diabetic retinopathy (DR) is the most frequent cause of blindness among younger adults in the western world. No blood biomarkers exist to detect DR. Hypothetically, Rhodopsin concentrations in blood has been suggested as an early marker for retinal damage. Read More

    Screening for diabetic retinopathy in children and young people in the UK: potential gaps in ascertainment of those at risk.
    Diabet Med 2017 Apr 4. Epub 2017 Apr 4.
    GOS Institute of Child Health, University College London, London, UK.
    Guidelines in the UK recommend that children and young people living with Type 1 and Type 2 diabetes undergo annual screening for diabetic retinopathy from the age of 12 years [1]. This is currently delivered though a large number of regional diabetic eye screening programmes that are responsible for identifying eligible children and young people, and inviting them to a screening appointment (Fig. 1). Read More

    The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy.
    BMC Complement Altern Med 2017 Apr 4;17(1):187. Epub 2017 Apr 4.
    Institute of Chinese Medicine, Beijing University of Chinese medicine, Beijing, China.
    Background: The Hippo signaling pathway is reported to be involved in angiogenesis, but the roles of the Hippo pathway in diabetic retinopathy have not been addressed. Fufang Xueshuantong Capsule has been used to treat diabetic retinopathy in China; however, the effect of Fufang Xueshuantong Capsule on the Hippo pathway has not been investigated.

    Methods: In this study, diabetes was induced in Sprague-Dawley rats with intraperitoneal injection of streptozotocin. Read More

    Platelet volume indices as predictive biomarkers for diabetic complications in Type 2 diabetic patients.
    J Lab Physicians 2017 Apr-Jun;9(2):84-88
    Department of Pathology, Dr. D. Y. Patil Medical College Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.
    Background: Platelet volume indices (PVI) such as mean platelet volume (MPV), platelet distribution width (PDW), and platelet-large cell ratio (P-LCR) are the indicators of increased platelet activity and can be considered as potential biomarkers for diabetic complications.

    Purpose: To study PVI in Type 2 diabetics with and without complications in comparison to nondiabetic patients.

    Materials And Methods: A case-control study was conducted on 300 Type 2 diabetics and 200 nondiabetics. Read More

    Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials.
    Lancet Diabetes Endocrinol 2017 Mar 29. Epub 2017 Mar 29.
    The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia.
    Background: Intensive glucose control is understood to prevent complications in adults with type 2 diabetes. We aimed to more precisely estimate the effects of more intensive glucose control, compared with less intensive glucose control, on the risk of microvascular events.

    Methods: In this meta-analysis, we obtained de-identified individual participant data from large-scale randomised controlled trials assessing the effects of more intensive glucose control versus less intensive glucose control in adults with type 2 diabetes, with at least 1000 patient-years of follow-up in each treatment group and a minimum of 2 years average follow-up on randomised treatment. Read More

    Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function.
    PLoS One 2017 30;12(3):e0174529. Epub 2017 Mar 30.
    Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
    Background: Aim of this study was to evaluate the prevalence of plantar fascia (PF) enthesopathy in Type 2 diabetes mellitus (T2DM) patients without distal peripheral neuropathy (DPN).

    Methods: We recruited 50 T2DM patients without DPN and 50 healthy controls. DPN was excluded using the Michigan Neuropathy Screening Instrument (MNSI). Read More

    HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo.
    Drug Des Devel Ther 2017 15;11:783-795. Epub 2017 Mar 15.
    Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, China.
    Background: Diabetic retinopathy (DR), one of the most common complications of late-phase diabetes, is associated with many risk factors, among which continuous low-grade inflammation is one of the principal ones. As such, lowering inflammation levels and maintain the viability of human retinal endothelial cells (HRECs) are critical for DR therapy. HMGB1 is a well-known proinflammatory cytokine. Read More

    Central Macular Thickness Monitoring after a Taxane-Based Therapy in Visually Asymptomatic Patients.
    Chemotherapy 2017 29;62(3):199-204. Epub 2017 Mar 29.
    Department of Ophthalmology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
    Background: Taxanes are drugs used in various chemotherapeutical protocols to treat solid tumors. They have multiple systemic adverse effects, such as bone marrow suppression, alopecia, nausea, and vomiting, and may rarely cause ocular symptoms. In the past decade, a few reported cases have shown the occurrence of a cystoid macular edema with significant visual loss after the use of a taxane-based chemotherapy. Read More

    Diabetic retinopathy: Knowledge, awareness and practices of physicians in primary-care centers in Riyadh, Saudi Arabia.
    Saudi J Ophthalmol 2017 Jan-Mar;31(1):2-6. Epub 2017 Jan 17.
    Department of Ophthalmology, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
    Purpose: Diabetic retinopathy (DR) is a serious cause of irreversible blindness and is the most common complication of diabetes. Annual fundus examination for diabetics aids in the prevention of blindness and allows intervening at a timely manner. As primary care physicians (PCP) are the main providers for diabetic care in Saudi Arabia, we aim to evaluate the current knowledge and awareness, and to assess practices among PCP regarding DR. Read More

    The incidence of diabetes mellitus and diabetic retinopathy in a population-based cohort study of people age 50 years and over in Nakuru, Kenya.
    BMC Endocr Disord 2017 Mar 23;17(1):19. Epub 2017 Mar 23.
    International Centre for Eye Health, Clinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.
    Background: The epidemic rise of diabetes carries major negative public health and economic consequences particularly for low and middle-income countries. The highest predicted percentage growth in diabetes is in the sub-Saharan Africa (SSA) region where to date there has been no data on the incidence of diabetic retinopathy from population-based cohort studies and minimal data on incident diabetes. The primary aims of this study were to estimate the cumulative six-year incidence of Diabetes Mellitus (DM) and DR (Diabetic Retinopathy), respectively, among people aged ≥50 years in Kenya. Read More

    Acute macular edema and peripapillary soft exudate after pancreas transplantation with accelerated progression of diabetic retinopathy.
    J Chin Med Assoc 2017 May 18;80(5):319-325. Epub 2017 Mar 18.
    Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Surgery, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
    Background: The effect of pancreas transplantation on diabetic retinopathy remains inconclusive. Herein, we report six patients with type 1 diabetes mellitus (DM) who underwent pancreas transplantation and developed acute macular edema and peripapillary soft exudate with rapid progression to proliferative diabetic retinopathy.

    Methods: In this retrospective observational study, diabetic patients who underwent pancreas transplantation in a single medical center and developed symptomatic acute macular edema and peripapillary soft exudate within 3 months after the operation were enrolled. Read More

    Time to Refocus Assessment of Vision in Older Adults? Contrast Sensitivity but Not Visual Acuity Is Associated With Gait in Older Adults.
    J Gerontol A Biol Sci Med Sci 2017 Feb 28. Epub 2017 Feb 28.
    Department of Medical Physics and Bioengineering, Mercer's Institute for Successful Ageing, St. James's Hospital, Dublin, Ireland.
    Background: The relationship between measures of visual function and gait related risk factors for falls is unclear. In this study, we examine the relationship between visual function (visual acuity [VA] and contrast sensitivity [CS] at multiple spatial frequencies) and quantitative spatiotemporal gait, using a large, nationally representative sample of community dwelling older adults.

    Methods: Participants aged 50 and over were recruited as part of The Irish Longitudinal Study on Ageing (TILDA). Read More

    Hyperglycaemic memory affects the neurovascular unit of the retina in a diabetic mouse model.
    Diabetologia 2017 Mar 20. Epub 2017 Mar 20.
    Fifth Medical Department, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
    Aims/hypothesis: The aim of this study was to evaluate damage to the neurovascular unit in a mouse model of hyperglycaemic memory.

    Methods: A streptozotocin-induced mouse model of diabetes (C57BL/6J background) received insulin-releasing pellets and pancreatic islet-cell transplantation. Damage to the neurovascular unit was studied by quantitative retinal morphometry for microvascular changes and microarray analysis, with subsequent functional annotation clustering, for changes of the retinal genome. Read More

    Evaluation of vitreous levels of advanced glycation end products and angiogenic factors as biomarkers for severity of diabetic retinopathy.
    Int Ophthalmol 2017 Mar 15. Epub 2017 Mar 15.
    Department of Medicine, Diabetes Center, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
    Background/aims: Glyceraldehyde-derived advanced glycation end products (glycer-AGE; also called Toxic-AGE [TAGE]) play a crucial role in the pathogenesis of diabetic angiopathy. However, the relationships between vitreous glycer-AGE levels and diabetic retinopathy (DR) severity, and between glycer-AGE levels and the levels of other angiogenic factors remain unknown. We investigated the correlation between levels of vitreous biomarkers, including glycer-AGE and angiogenic factors (vascular endothelial growth factor [VEGF], interleukin [IL]-8, leptin, placental growth factor [PlGF], endoglin, and fibroblast growth factor [FGF]-2) in patients with DR, using three DR staging groups. Read More

    Optometry Australia Scope of Practice Survey 2015.
    Clin Exp Optom 2017 Mar 13. Epub 2017 Mar 13.
    Primary Health Care Research & Information Service, Flinders University, Bedford Park, South Australia, Australia.
    Background: This paper presents results from the inaugural Scope of Practice Survey of Optometry Australia members conducted in October 2015. The survey gathered information related to confidence in detecting and diagnosing key ocular conditions, grading diabetic retinopathy, prescribing scheduled medicines, access to equipment, confidence using equipment, incidence of patients requiring therapeutic management, referral practices and services provided.

    Methods: The survey was developed, piloted, modified and administered to members of Optometry Australia (excluding student and retired members), who had a current email address. Read More

    Availability and variability in guidelines on diabetic retinopathy screening in Asian countries.
    Br J Ophthalmol 2017 Mar 14. Epub 2017 Mar 14.
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
    Background: Diabetic retinopathy (DR) is a blinding yet treatable complication of diabetes. DR screening is highly cost-effective at reducing blindness. Amidst the rapidly growing diabetic population in Asia, the prevalence of DR in the region is relatively less well known. Read More

    Retin Cases Brief Rep 2017 Mar 13. Epub 2017 Mar 13.
    *Department of Ophthalmology, University Hospital Geelong, Geelong, Australia; and †Department of Haematology, University Hospital Geelong, Geelong, Australia.
    Purpose: To report on a 39-year-old gentleman with a background of Type 2 diabetes mellitus who was diagnosed with acute promyelocytic leukemia (APL), which was treated by all-trans retinoic acid (ATRA), and subsequently developed bilateral neovascularization of the disk (NVD).

    Methods: Ophthalmic examination and investigation including fundus photography and fluorescein angiography.

    Results: Three months after commencement of ATRA therapy, the patient was found to have florid bilateral NVD with adjacent preretinal and intraretinal hemorrhages. Read More

    Bevacizumab and Panretinal photocoagulation protect against ocular hypertension after posterior subtenon injection of triamcinolone acetonide for diabetic macular edema.
    J Formos Med Assoc 2016 Oct 27. Epub 2016 Oct 27.
    Division of Biostatistics, Graduate Institute of Epidemiology & Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: To analyze the prognostic factors for ocular hypertension after posterior subtenon injection of triamcinolone acetonide (PSTA) for the treatment of diabetic macular edema (DME).

    Methods: Patients who received PSTA for DME from January 2006 to December 2011 were enrolled retrospectively and were followed until December 2012 in one hospital. Modified Cox regression models were used to analyze the factors associated with ocular hypertension, which was defined as an intraocular pressure>21 mmHg after PSTA. Read More

    Differences in incidence of diabetic retinopathy between type 1 and 2 diabetes mellitus: a nine-year follow-up study.
    Br J Ophthalmol 2017 Mar 7. Epub 2017 Mar 7.
    Ophthalmology Service, University Hospital Sant Joan, Reus, Spain.
    Background/aims: To determine the incidence of any diabetic retinopathy (any-DR), sight-threatening diabetic retinopathy (STDR) and diabetic macular oedema (DMO) and their risk factors in type 1 diabetes mellitus (T1DM) over a screening programme.

    Methods: Nine-year follow-up, prospective population-based study of 366 patients with T1DM and 15 030 with T2DM. Epidemiological risk factors were as follows: current age, age at DM diagnosis, sex, type of DM, duration of DM, arterial hypertension, levels of glycosylated haemoglobin (HbA1c), triglycerides, cholesterol fractions, serum creatinine, estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR). Read More

    Deep neural ensemble for retinal vessel segmentation in fundus images towards achieving label-free angiography.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:1340-1343
    Automated segmentation of retinal blood vessels in label-free fundus images entails a pivotal role in computed aided diagnosis of ophthalmic pathologies, viz., diabetic retinopathy, hypertensive disorders and cardiovascular diseases. The challenge remains active in medical image analysis research due to varied distribution of blood vessels, which manifest variations in their dimensions of physical appearance against a noisy background. Read More

    Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls.
    PLoS One 2017 6;12(3):e0173379. Epub 2017 Mar 6.
    Department of Ophthalmology, University of Groningen, University Medical Center Groningen (UMCG), the Netherlands.
    Purpose: Advanced glycation endproducts (AGEs) and their precursors α-dicarbonyls are implicated in the progression of diabetic retinopathy. The purpose of this study was to assess AGEs and α-dicarbonyls in the vitreous of patients with type 2 diabetes mellitus (T2DM) with early stages or absence of diabetic retinopathy.

    Methods: We examined vitreous samples obtained during vitrectomy from 31 T2DM patients presenting themselves with rhegmatogenous retinal detachment and compared these to 62 non-diabetic rhegmatogenous retinal detachment patients, matched on age, estimated glomerular filtration rate, smoking, intra-ocular lens implantation, and proliferative vitreoretinopathy. Read More

    Retinal imaging with smartphone.
    Niger J Clin Pract 2017 Mar;20(3):341-345
    Department of Ophthalmology, University of Ilorin and University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
    Background: The use of smartphones for various purposes among health professionals is increasing, especially with the availability of different applications. On account of cost, fundus cameras are not readily available in ophthalmic practice in developing countries. Since smartphones are readily available, easy to use and portable, they may present a cheap alternative in a resource-limited economy. Read More

    Prevalence and factors associated with diabetic retinopathy among diabetic patients at Arbaminch General Hospital, Ethiopia: Cross sectional study.
    PLoS One 2017 2;12(3):e0171987. Epub 2017 Mar 2.
    Department of Maternity and Reproductive Health Nursing, Wolaita Sodo University, Wolaita, Ethiopia.
    Background: Currently 93 million people are estimated as living with diabetic retinopathy worldwide. The prevalence and risk factors of diabetic retinopathy in developed countries have been well documented; but in Ethiopia, data on prevalence and associated factors of diabetic retinopathy is lacking.

    Objective: To determine prevalence and factors associated with development of diabetic retinopathy among diabetic patients at Arbaminch General Hospital, Ethiopia. Read More

    Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy.
    J Nanobiotechnology 2017 Mar 1;15(1):18. Epub 2017 Mar 1.
    Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
    Background: Diabetic retinopathy is the most common complication in diabetic patients relates to high expression of VEGF and microaneurysms. Scutellarin (Scu) turned out to be effective against diabetes related vascular endothelial cell dysfunction. However, its clinical applications have been limited by its low bioavailability. Read More

    Long noncoding RNA MIAT acts as a biomarker in diabetic retinopathy by absorbing of miR-29b and regulating cell apoptosis.
    Biosci Rep 2017 Feb 28. Epub 2017 Feb 28.
    The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
    Background: Diabetic retinopathy (DR) is the complication of diabetic mellitus (DM), and is a leading cause of vision loss globally. However, the pathogenic mechanism and clinical therapy still needs further improvement. The biologic significance of myocardial infarction associated transcript (MIAT) in DR remains unknown, Here we aims to explore the mechanism between MIAT and DR, which was essential for RD. Read More

    Pulmonary Function and Retrobulbar Hemodynamics in Subjects With Type 2 Diabetes Mellitus.
    Respir Care 2017 Feb 28. Epub 2017 Feb 28.
    Department of Endocrinology and Metabolism, Shenyang the Fourth Hospital of People, Shenyang, China.
    Background: The primary goals of this study were to evaluate early changes in pulmonary function and retrobulbar hemodynamics and to examine the correlation between these parameters in patients with type 2 diabetes during the preclinical stages of diabetic retinopathy.

    Methods: For the single-time point measurements, 63 subjects with type 2 diabetes without diabetic retinopathy (diabetes group) and 32 healthy subjects (control group) were selected to evaluate any early changes in pulmonary function and retrobulbar hemodynamics and to examine the correlation between these parameters. In the longitudinal follow-up study, 32 subjects who were newly diagnosed with type 2 diabetes were divided into 2 groups according to their resistivity index (≤0. Read More

    Ischemic Optic Neuropathy in Cardiac Surgery: Incidence and Risk Factors in the United States from the National Inpatient Sample 1998 to 2013.
    Anesthesiology 2017 May;126(5):810-821
    From the Department of Anesthesia and Critical Care (D.S.R., A.T.), and Department of Anesthesia and Critical Care, The Center for Health and the Social Sciences (S.R.), The University of Chicago Medicine, Chicago, Illinois; Pritzker School of Medicine of the University of Chicago, Chicago, Illinois (M.M.M.); Department of Ophthalmology and Visual Science, Department of Neurology and Rehabilitation, College of Medicine, University of Illinois at Chicago, Chicago, Illinois (H.E.M.); Department of Ophthalmology and Visual Science, College of Medicine, Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois (C.E.J.); and Department of Anesthesiology, Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, Illinois (S.R.). Current position: Department of Ophthalmology, Byers Eye Center, Stanford University, Palo Alto, California (H.E.M.).
    Background: Ischemic optic neuropathy is the most common form of perioperative visual loss, with highest incidence in cardiac and spinal fusion surgery. To date, potential risk factors have been identified in cardiac surgery by only small, single-institution studies. To determine the preoperative risk factors for ischemic optic neuropathy, the authors used the National Inpatient Sample, a database of inpatient discharges for nonfederal hospitals in the United States. Read More

    Anatomical and visual outcome of intravitreal bevacizumab (Avastin) in patients with diabetic macular edema.
    Nepal J Ophthalmol 2016 Jan;8(15):54-61
    Background: Intravitreal bevacizumab has been shown to be an effective treatment of diabetic macular edema.

    Objective: To assess the anatomical and visual outcome of intravitrealbevacizumab (Avastin) in patients of diabetic macular edema.

    Materials And Methods: 52 eyes of 33 patients with diabetic retinopathy with CSME were included in this study. Read More

    An improved arteriovenous classification method for the early diagnostics of various diseases in retinal image.
    Comput Methods Programs Biomed 2017 Apr 17;141:3-9. Epub 2017 Jan 17.
    The Key Laboratory of Biomedical Information Engineering, Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China. Electronic address:
    (background And Objectives): Retinal artery and vein classification is an important task for the automatic computer-aided diagnosis of various eye diseases and systemic diseases. This paper presents an improved supervised artery and vein classification method in retinal image.

    (methods): Intra-image regularization and inter-subject normalization is applied to reduce the differences in feature space. Read More

    Statins and Fibrates for Diabetic Retinopathy: Protocol for a Systematic Review.
    JMIR Res Protoc 2017 Feb 22;6(2):e30. Epub 2017 Feb 22.
    Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
    Background: Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus, and more than 75% of patients who have had diabetes for more than 20 years will have some degree of DR. This disease is highly destructive to self-esteem and puts a high burden on public health and pension systems due to the effects that it has on people of working age. The current mainstay of treatment is laser photocoagulation, which causes impairment of vision and discomfort to patients. Read More

    What do patients with diabetes and providers think of an innovative Australian model of remote diabetic retinopathy screening? A qualitative study.
    BMC Health Serv Res 2017 Feb 22;17(1):158. Epub 2017 Feb 22.
    Discipline of General Practice, University of Queensland, Royal Brisbane Hospital, Level 8 Health Sciences Building, Herston, QLD, 4029, Australia.
    Background: Diabetic retinopathy (DR) is the commonest cause of preventable blindness in working age populations, but up to 98% of visual loss secondary to DR can be prevented with early detection and treatment. In 2012, an innovative outreach DR screening model was implemented in remote communities in a state of Australia. The aim of this study was to explore the acceptability of this unique DR screening model to patients, health professionals and other key stakeholders. Read More

    Blocking IL-17A Alleviates Diabetic Retinopathy in Rodents.
    Cell Physiol Biochem 2017 Feb 21;41(3):960-972. Epub 2017 Feb 21.
    Background/aims: Interleukin (IL)-17A, a proinflammatory cytokine, has been implicated in several autoimmune diseases. However, it is unclear whether IL-17A is involved in diabetic retinopathy (DR), one of the most serious complications of autoimmune diabetes. This study aimed to demonstrate that IL-17A exacerbates DR by affecting retinal Müller cell function. Read More

    A low prevalence of non alcoholic fatty liver disease in patients with type 1 diabetes is associated to decreased subclinical cardiovascular disease.
    J Diabetes 2017 Feb 20. Epub 2017 Feb 20.
    Service of Endocrinology and Nutrition, Department of Medicine, Institute of Research and Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERDEM and CIBERER, Instituto de Salud Carlos III, Spain.
    Background: Non-alcoholic fatty liver disease (NAFLD) has been proposed as an independent cardiovascular risk factor. This study evaluated the prevalence of NAFLD in a cohort of Type 1 Diabetic (T1D) patients and its potential relationship with subclinical cardiovascular disease (CVD).

    Methods: Cross-sectional study in which 100 T1D patients (39. Read More

    Pseudophakic cystoid macular edema prevention and risk factors; prospective study with adjunctive once daily topical nepafenac 0.3% versus placebo.
    BMC Ophthalmol 2017 Feb 20;17(1):16. Epub 2017 Feb 20.
    Arizona Eye Consultants, 355 N. Silverbell Ave, Tucson, AZ, 85745, USA.
    Background: Define the effectiveness of a topical non-steroidal anti-inflammatory drug (NSAID) added to topical steroid use after uncomplicated phacoemulsification for the prevention of pseudophakic cystoid macular edema (PCME) using a prospective, randomized, double-masked, placebo-controlled clinical study.

    Methods: Eyes (1000) were randomized to placebo (497) or nepafenac 0.3% (503) used once daily, post-operatively for 5 weeks at two ophthalmology clinics. Read More

    Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients.
    Cardiovasc Diabetol 2017 Feb 15;16(1):24. Epub 2017 Feb 15.
    INSERM U-1088, Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications, 80025, Amiens, France.
    Background: Vascular calcification (VC) is common in type 2 diabetes, and is associated with cardiovascular complications. Recent preclinical data suggest that metformin inhibits VC both in vitro and in animal models. However, metformin's effects in patients with diabetic VC have not previously been characterized. Read More

    Efficacy of the Intravitreal Sustained-Release Dexamethasone Implant for Diabetic Macular Edema Refractory to Anti-Vascular Endothelial Growth Factor Therapy: Meta-Analysis and Clinical Implications.
    Ophthalmic Surg Lasers Imaging Retina 2017 Feb;48(2):160-166
    Background And Objective: To assess the effect on best-corrected visual acuity (BCVA) and efficacy of the intravitreal sustained-release 0.7 mg dexamethasone implant (Ozurdex; Allergan, Irvine, CA) in patients with recalcitrant diabetic macular edema (DME).

    Patients And Methods: Meta-analysis utilizing the MOOSE framework and a random effects model. Read More

    [Indications for Retinal Laser Therapy Revisited].
    Klin Monbl Augenheilkd 2017 Feb 10. Epub 2017 Feb 10.
    Zentrum für Augenheilkunde, Universität zu Köln.
    Background Laser therapy is an important treatment option in retinal diseases, especially in cases of vascular involvement. Most approaches are based on coagulation of retinal structures. As there is increasing use of agents targetting vascular endothelial growth factor in the treatment of macular diseases, indications for the use of laser treatment need to be reviewed carefully, especially with respect to their significance in first line therapy. Read More

    The A445C Variant in Apelin Receptor and Diabetic Retinopathy in Tunisian Patients.
    Clin Lab 2017 Feb;63(2):379-383
    Background: Apelin and apelin receptor (APLN/APLNR) are involved in the retinal neovascularization of diabetic retinopathy (DR).

    Methods: This study investigated the impact of the APLNR A445C variant on the risk of DR in a sample of the Tunisian population (100 patients with DR and 105 healthy controls) using PCR-RFLP.

    Results: The genotype frequencies of the APLNR A445C variant were not significantly different between the patient and control groups. Read More

    Circulating monocytes and B-lymphocytes in neovascular age-related macular degeneration.
    Clin Ophthalmol 2017 17;11:179-184. Epub 2017 Jan 17.
    Clinical Eye Research Unit, Zealand University Hospital, Roskilde; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Background: Individuals with neovascular age-related macular degeneration (AMD) have altered number and distribution of retinal macrophages and show changes in circulating antibodies. We wanted to investigate the corresponding precursors, with subpopulations. We therefore measured monocyte and B-lymphocyte populations in individuals with neovascular AMD. Read More

    Auckland cataract study 2: clinical outcomes of phacoemulsification cataract surgery in a public teaching hospital.
    Clin Exp Ophthalmol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Science, University of Auckland, Auckland, New Zealand.
    Importance: A contemporary benchmark for the most common ophthalmic surgery.

    Background: To assess patient characteristics and outcomes of contemporary phacoemulsification cataract surgery in a New Zealand public teaching hospital setting.

    Design: Prospective observational study. Read More

    [The protective effect of human umbilical cord mesenchymal stem cells-induced neural stem cells in the vitreous on the blood-retinal barrier in diabetic rats].
    Zhonghua Yan Ke Za Zhi 2017 Jan;53(1):53-58
    Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science, Tianjin Institute of Ophthalmology, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin 300020, China.
    Objective: To investigate the effect of intravitreal injection of neural stem cells (NSC) induced from human umbilical cord mesenchymal stem cells, and to provide a theoretical basis for the clinical treatment of blood-retinal barrier damage due to diabetic retinopathy (DR). Methods: Experimental study. Sixty male Sprague-Dawley rats were randomly divided into control group, DR group and NSC group. Read More

    Membranous nephropathy occurring with type 2 diabetes mellitus
    Clin Nephrol 2017 Mar;87 (2017)(3):140-146
    Background: The incidence of type 2 diabetes mellitus (T2DM) is increasing, and membranous nephropathy (MN) occurs frequently with T2DM. We investigated the clinicopathological features and outcomes of patients with T2DM and MN.

    Methods: A total of 137 patients with biopsy-proven MN and T2DM were enrolled in this retrospective study. Read More

    Role of oxidative stress in epigenetic modification of MMP-9 promoter in the development of diabetic retinopathy.
    Graefes Arch Clin Exp Ophthalmol 2017 May 25;255(5):955-962. Epub 2017 Jan 25.
    Kresge Eye Institute, Wayne State University, Detroit, MI, 48201, USA.
    Background: In the pathogenesis of diabetic retinopathy, damaged retinal mitochondria accelerate apoptosis of retinal capillary cells, and regulation of oxidative stress by manipulating mitochondrial superoxide dismutase (SOD2) protects mitochondrial homeostasis and prevents the development of diabetic retinopathy. Diabetes also activates matrix metalloproteinase-9 (MMP-9), and activated MMP-9 damages retinal mitochondria. Recent studies have shown a dynamic DNA methylation process playing an important role in regulation of retinal MMP-9 transcription in diabetes; the aim of this study is to investigate the role of oxidative stress in MMP-9 transcription. Read More

    Progranulin, a new adipokine at the crossroads of metabolic syndrome, diabetes, dyslipidemia and hypertension.
    Curr Pharm Des 2017 Jan 24. Epub 2017 Jan 24.
    Department of Pathophysiology, Medical University, Lublin, Poland.
    Background: Progranulin is a multifunctional regulatory protein with growth-promoting, neuroprotective and antiinflammatory activities. Recent studies indicate that progranulin is one of the adipose tissue hormones (adipokines). Progranulin expression in visceral adipose tissue and circulating progranulin concentration are increased in obesity and hyperprogranulinemia is involved in the pathogenesis of obesity-associated insulin resistance. Read More

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