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    Possible neuroprotective role of P2X2 in the retina of diabetic rats.
    Diabetol Metab Syndr 2018 12;10:31. Epub 2018 Apr 12.
    1Department of Ophthalmology, Nanomedicine & Vision Group, Facultad de Ciencias Biomédicas, Universidad Austral, Av. Juan D. Perón 1500, B1629AHJ Pilar, Buenos Aires Argentina.
    Background: Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P2 receptors. Read More

    Review of economic evaluations of teleophthalmology as a screening strategy for chronic eye disease in adults.
    Br J Ophthalmol 2018 Apr 21. Epub 2018 Apr 21.
    Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Canada
    Background/aims: Teleophthalmology is well positioned to play a key role in screening of major chronic eye diseases. Economic evaluation of cost-effectiveness of teleophthalmology, however, is lacking. This study provides a systematic review of economic studies of teleophthalmology screening for diabetic retinopathy (DR), glaucoma and macular degeneration. Read More

    Abnormally low Bispectral index and severe hypoglycemia during maintenance of and recovery from general anesthesia in diabetic retinopathy surgery: two case reports.
    BMC Anesthesiol 2018 Apr 20;18(1):45. Epub 2018 Apr 20.
    Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Tieyilu 10, Yangfangdian, Haidian District, Beijing, 100038, China.
    Background: Hypoglycemia is one of the most fatal complications during the perioperative period. General anesthesia or sedation can mask a hypoglycemia-altered mental status. Acute hypoglycemia might result in permanent brain injury. Read More

    Associations of Diabetic Retinopathy with Retinal Neurodegeneration on the Background of Diabetes Mellitus. Overview of Recent Medical Studies with an Assessment of the Impact on Healthcare systems.
    Open Med (Wars) 2018 18;13:130-136. Epub 2018 Apr 18.
    Ophthalmology Clinic Medical Centre of Postgraduate Education Warsaw, Warsaw Poland.
    Diabetes Mellitus (DM) is one of the biggest healthcare and financial problems worldwide. The disease is strongly associated with microvascular and macrovascular complications, causing co-existing diseases like Diabetic Retinopathy, Diabetic Neuropathy and Diabetic Nephropathy. Annual healthcare expenditures for diabetes treatment and complications prevention cost 727 billion USD in year 2017. Read More

    Recovery from Diabetic Macular Edema in a Diabetic Patient After Minimal Dose of a Sodium Glucose Co-Transporter 2 Inhibitor.
    Am J Case Rep 2018 Apr 19;19:462-466. Epub 2018 Apr 19.
    Wakisaka Internal Medicine Clinic, Fukuoka City, Fukuoka, Japan.
    BACKGROUND Diabetic macular edema (DME) causes serious visual impairments in diabetic patients. The standard treatments of DME are intra-vitreous injections of corticosteroids or anti-vascular endothelial growth factor antibodies and pan-photocoagulation. These treatments are unsatisfactory in their effects and impose considerable physical and economic burdens on the patients. Read More

    The effect of fenofibrate on early retinal nerve fiber layer loss in type 2 diabetic patients: a case-control study.
    BMC Ophthalmol 2018 Apr 18;18(1):100. Epub 2018 Apr 18.
    Department of Ophthalmology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.
    Background: Previous studies suggested that use of fenofibrate could significantly reduce the rate of progression into diabetic retinopathy (DR), and that retinal nerve fiber layer (RNFL) loss, which has been considered an important indicator for retinal neurodegeneration, might precede microvascular changes. The aim of this study was to assess the effect(s) of fenofibrate on RNFL thickness at early stage of DR in patients with type 2 diabetes mellitus (DM).

    Methods: In this retrospective matched case-control study we included a cohort of 89 patients with type 2 DM, aged 40 or above, between Jan 1, 2017 and March 31, 2017. Read More

    Association Between Metabolic Syndrome and Microvascular and Macrovascular Disease in Type 2 Diabetic Mellitus.
    Am J Med Sci 2018 Apr 9;355(4):342-349. Epub 2017 Dec 9.
    Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Background: The prevalence of metabolic syndrome (MetS) in patients with type 2 diabetes mellitus is high. The aim of this study was to investigate the association between MetS and micro- and macrovascular disease in patients with diabetes and the associated risk factors.

    Methods: The study enrolled 1,986 (854 men and 1,132 women) patients with type 2 diabetes mellitus from outpatient clinics. Read More

    Uric acid is not associated with diabetic nephropathy and other complications in type 1 diabetes.
    Nephrol Dial Transplant 2018 Apr 11. Epub 2018 Apr 11.
    Steno Diabetes Center Copenhagen, Gentofte, Denmark.
    Background: To examine the association between plasma uric acid (UA) and the presence of diabetic complications including diabetic nephropathy and cardiovascular risk factors in patients with type 1 diabetes.

    Methods: This study, which is cross-sectional in design, included 676 Caucasian type 1 diabetes patients from the Steno Diabetes Center Copenhagen. Participants with UA within the three lowest sex-specific quartiles were compared with participants with levels in the highest quartile. Read More

    Resistive index of ophthalmic artery correlates with retinal pigment epithelial alterations on spectral domain optical coherence tomography in diabetic retinopathy.
    Int J Retina Vitreous 2018 9;4:12. Epub 2018 Apr 9.
    Department of Ophthalmology, Pallas Klinik, Aarau, Switzerland.
    Background: Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapillaries. RPE topographic alterations have been observed to be associated with severity of retinopathy. Read More

    Alteration of layer thickness in the choroid of diabetic patients.
    Clin Exp Ophthalmol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.
    Importance: Choroidal thickness changes in diabetic retinopathy improve understanding the pathophysiology and managements of this disease.

    Background: To examine the choroidal layer thickness in diabetes mellitus (DM) patients and normal individuals, and to compare the findings based on medical history of systemic DM treatments, and stage of diabetic retinopathy (DR).

    Design: Case control study. Read More

    Calcium dobesilate: A drug treatment for diabetic retinopathy can negatively interfere with the measurement of glycated albumin using the enzymatic method.
    Clin Chim Acta 2018 Apr 10;483:1-5. Epub 2018 Apr 10.
    Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College, Beijing, PR China. Electronic address:
    Background: We reported that calcium dobesilate, a vasoprotective agent mainly used for diabetic retinopathy (DR), negatively interferes with glycated albumin (GA) assays involving enzymatic methods.

    Methods: A calcium dobesilate standard was added to 3serum pools in vitro to prepare concentration-response series according to Clinical and Laboratory Standards Institute EP7-A2 guidelines. Percentage deviation between each drug concentration and the drug-free sample was calculated for 6 commercially available GA assays. Read More

    The prevalence and systemic risk factors of diabetic macular edema: a cross-sectional study from Turkey.
    BMC Ophthalmol 2018 Apr 12;18(1):91. Epub 2018 Apr 12.
    Department of Ophthalmology, Dokuz Eylul University School of Medicine, Izmir, Turkey.
    Background: The aim of this study was to evaluate the prevalence of diabetic macular edema (DME) utilizing optical coherence tomography (OCT), and to clarify the effects of the systemic findings and risk factors on the development of DME.

    Methods: This cross-sectional study was conducted in the departments of ophthalmology and endocrinology at the Dokuz Eylul University School of Medicine in Izmir, Turkey. The demographics, type and duration of diabetes mellitus, treatment modality, smoking and alcohol consumption habits, as well as the systemic blood pressure, renal functional tests, hemoglobulin A1c level, serum lipid profile, and 24-h urine albumin level were noted and statistically analyzed. Read More

    Clinical Efficacy and Safety of the EX-PRESS Filtration Device in Patients with Advanced Neovascular Glaucoma and Proliferative Diabetic Retinopathy.
    Case Rep Ophthalmol 2018 Jan-Apr;9(1):61-69. Epub 2018 Jan 23.
    Department of Ophthalmology, Rabin Medical Center, Beilinson Hospital, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: The prognosis of conventional filtration surgery in eyes with neovascular glaucoma (NVG) is limited due to increased fibrovascular proliferation or bleeding. This study aims to evaluate the safety and efficacy of the EX-PRESS filtration device in the management of NVG associated with proliferative diabetic retinopathy (PDR).

    Methods: In this retrospective case series, we reviewed the medical records of patients diagnosed as having NVG associated with PDR who underwent EX-PRESS filtration surgery. Read More

    Diabetic retinopathy may predict the renal outcomes of patients with diabetic nephropathy.
    Ren Fail 2018 Nov;40(1):243-251
    a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , China.
    Background: The patients with Type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) are prone to develop diabetic nephropathy (DN). In this study, we aimed to clarify the relationship between DR and the progression of DN in patients with T2DM.

    Methods: In the cross-section study, 250 patients with T2DM and biopsy-proven DN were divided into two groups: 130 in the DN without DR group (DN group) and 120 in the DN + DR group. Read More

    Lower limb ischemia and microrheological alterations in patients with diabetic retinopathy.
    Clin Hemorheol Microcirc 2018 Apr 3. Epub 2018 Apr 3.
    First Department of Medicine, University of Pecs, Medical School, Hungary.
    Background: Diabetes mellitus is frequently associated with vascular pathologies and hemorheological disorders.

    Methods: 105 patients with diabetic retinopathy (DRP) (mean age 64.64±9. Read More

    Influences of Pinpoint Plantar Long-Wavelength Infrared Light Irradiation (Stress-Free Therapy) on Chorioretinal Hemodynamics, Atherosclerosis Factors, and Vascular Endothelial Growth Factor.
    Integr Med Res 2018 Mar 3;7(1):103-107. Epub 2018 Jan 3.
    Faculty of Health Sciences, Ryotokuji University, Urayasu, Japan.
    Background: We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) is useful for alleviating insulin resistance and improving intracranial blood flow in patients with type 2 diabetes mellitus. This study was undertaken to evaluate the influences of SFT on chorioretinal hemodynamics (retinal artery and vein blood flows) as well as atherosclerosis-related factors (TG, LDL-C) and VEGF in patients with dyslipidemia.

    Methods: Four patients with dyslipidemia received 15-minute irradiation with a stress-free apparatus (far-infrared wavelength, 30 mW). Read More

    Awareness of diabetic retinopathy among people with diabetes in Jeddah, Saudi Arabia.
    Ther Adv Endocrinol Metab 2018 Apr 4;9(4):103-112. Epub 2018 Mar 4.
    Department of Pediatrics, Faculty of Medicine, Assiut University Assiut, Egypt.
    Background: Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus (DM) and the foremost cause of blindness. This study aimed to assess the level of awareness of DR and its related risk factors among patients with DM in Jeddah, Saudi Arabia.

    Methods: A cross-sectional study was conducted among patients with DM attending primary health care centers at the Ministry of Health in Jeddah. Read More

    Knowledge, attitude, and practice of diabetic retinopathy among physicians in Northwestern Nigeria.
    Niger J Clin Pract 2018 Apr;21(4):478-483
    Department of Internal Medicine, Bayero University Kano, Aminu Kano Teaching Hospital, Kano, Kano State, Nigeria.
    Background: Diabetic retinopathy (DR) is the leading cause of preventable blindness in the productive population that poses a considerable global public health burden.

    Objective: The objective of this study is to assess the knowledge, attitude, and practice of DR screening among physicians in Northwestern Nigeria. Materials and Methods: Survey responses were obtained from 105 physicians in 4 tertiary hospitals using a Likert scale questionnaire. Read More

    Regional differences in the prevalence of diabetic retinopathy: a multi center study in Brazil.
    Diabetol Metab Syndr 2018 14;10:17. Epub 2018 Mar 14.
    1Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro, 77, Vila Isabel, Rio de Janeiro, RJ Zip Code: 20551-030 Brazil.
    Background: Diabetic retinopathy has a significant impact in every healthcare system. Despite that fact, there are few accurate estimates in the prevalence of DR in Brazil's different geographic regions, particularly proliferative DR and diabetic macular edema. This study aims to determine the prevalence of diabetic retinopathy in Brazil's five continental regions and its determinant factors. Read More

    Orthopedic aspects of the diabetic foot.
    Curr Pharm Des 2018 Mar 28. Epub 2018 Mar 28.
    Department of Internal Medicine / Infectious Diseases, University of Groningen, University Medical Centre Groningen, Groningen. Netherlands.
    Background Diabetes Mellitus (DM) is a common medical condition affecting more than 6% of the world population. Besides well-known pathology like diabetic retinopathy and renal insufficiency, it carries important orthopedic implications, especially around the foot and ankle (diabetic foot). Focus This article focusses on the three major areas confronting the orthopedist: 1) changes in foot statics and biology leading to ulceration with or without osteomyelitis, 2) ankle fractures, particularly complications after a fracture and 3) Charcot foot. Read More

    Biochemical scenario behind initiation of diabetic retinopathy in type 2 diabetes mellitus.
    Indian J Ophthalmol 2018 Apr;66(4):535-540
    Department of Ophthalmology, IPGME and R, Kolkata, West Bengal, India.
    Purpose: Despite the disease having similar glycemic status and duration microangiopathy in some patients develop within few years whereas it doesn't appear as a health complication in some diabetics for a considerable period. This study is undertaken to assess the hyperglycemia-induced biochemical background behind the development of diabetic retinopathy (DR) in type 2 diabetes mellitus (DM).

    Methods: Following proper diagnosis, 100 patients of type 2 DM of 10-12 years duration having no DR, and 42 patients of type 2 DM of the same duration and glycemic status as the second group, with mild retinopathy were recruited in the study. Read More

    Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis.
    J Vis Exp 2018 Mar 8(133). Epub 2018 Mar 8.
    Department of Clinical Neuroscience, Section of Eye and Vision, St Erik Eye Hospital, Karolinska Institutet;
    We describe a model of puncture-induced iris neovascularization as a general model for noninvasive evaluation of angiogenesis. The model is also relevant for targeting neovascular glaucoma, a sight-threatening complication of diabetic retinopathy. This method is based on the induction of iris vascular response by a series of self-sealing uveal punctures on BALB/c mice and takes advantage of the postpartum maturation of mouse ocular vasculature. Read More

    Immune thrombocytopenic purpura presenting in a patient after renal transplant for diabetic nephropathy.
    BMC Nephrol 2018 Mar 20;19(1):69. Epub 2018 Mar 20.
    Rawalpindi Medical College, Rawalpindi, Pakistan.
    Background: Immune thrombocytopenic purpura (ITP) is primarily characterized by immune-mediated destruction of platelets in circulation. Major treatment options range from careful observation, steroids, immunosuppressive medications, immunoglobulins to splenectomy. Interestingly and rarely, ITP has also been reported after solid organ transplantation in patients receiving immunosuppressive medications. Read More

    Procoagulant Activity of Blood and Endothelial Cells via Phosphatidylserine Exposure and Microparticle Delivery in Patients with Diabetic Retinopathy.
    Cell Physiol Biochem 2018 Mar 15;45(6):2411-2420. Epub 2018 Mar 15.
    Department of Hematology, First Affiliated Hospital, Harbin Medical University, Harbin, China.
    Background/aims: The mechanisms for thrombosis in diabetic retinopathy (DR) are complex and need to be further elucidated. The purpose of this study was to test phosphatidylserine (PS) exposure on microparticles (MPs) and MP-origin cells from the circulation and to analyze cell-/MP-associated procoagulant activity (PCA) in DR patients.

    Methods: PS-positive MPs and cells from healthy controls (n = 20) and diabetic patients (n = 60) were analyzed by flow cytometry and confocal microscopy. Read More

    Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections.
    Br J Ophthalmol 2018 May 15;102(5):575-585. Epub 2018 Mar 15.
    Brien Holden Vision Institute, Sydney, New South Wales, Australia.
    Background: Within a surveillance of the prevalence and causes of vision impairment in high-income regions and Central/Eastern Europe, we update figures through 2015 and forecast expected values in 2020.

    Methods: Based on a systematic review of medical literature, prevalence of blindness, moderate and severe vision impairment (MSVI), mild vision impairment and presbyopia was estimated for 1990, 2010, 2015, and 2020.

    Results: Age-standardised prevalence of blindness and MSVI for all ages decreased from 1990 to 2015 from 0. Read More

    Hard exudates segmentation based on learned initial seeds and iterative graph cut.
    Comput Methods Programs Biomed 2018 May 20;158:173-183. Epub 2018 Feb 20.
    School of Computing and Communications, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, Australia. Electronic address:
    (Background and Objective): The occurrence of hard exudates is one of the early signs of diabetic retinopathy which is one of the leading causes of the blindness. Many patients with diabetic retinopathy lose their vision because of the late detection of the disease. Thus, this paper is to propose a novel method of hard exudates segmentation in retinal images in an automatic way. Read More

    Automated choroid segmentation of three-dimensional SD-OCT images by incorporating EDI-OCT images.
    Comput Methods Programs Biomed 2018 May 4;158:161-171. Epub 2017 Nov 4.
    Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address:
    Background And Objective: The measurement of choroidal volume is more related with eye diseases than choroidal thickness, because the choroidal volume can reflect the diseases comprehensively. The purpose is to automatically segment choroid for three-dimensional (3D) spectral domain optical coherence tomography (SD-OCT) images.

    Methods: We present a novel choroid segmentation strategy for SD-OCT images by incorporating the enhanced depth imaging OCT (EDI-OCT) images. Read More

    Different lasers and techniques for proliferative diabetic retinopathy.
    Cochrane Database Syst Rev 2018 03 15;3:CD012314. Epub 2018 Mar 15.
    Ophthalmology Department, Royal Victoria Hospital, Grosvenor Road, Belfast, UK, BT12 6BA.
    Background: Diabetic retinopathy (DR) is a chronic progressive disease of the retinal microvasculature associated with prolonged hyperglycaemia. Proliferative DR (PDR) is a sight-threatening complication of DR and is characterised by the development of abnormal new vessels in the retina, optic nerve head or anterior segment of the eye. Argon laser photocoagulation has been the gold standard for the treatment of PDR for many years, using regimens evaluated by the Early Treatment of Diabetic Retinopathy Study (ETDRS). Read More

    Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis.
    Clin Proteomics 2018 9;15:12. Epub 2018 Mar 9.
    1Department of Ophthalmology, Shanghai General Hospital, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai Engineering Center for Visual Science and Photomedicine, No. 100 Haining Road, Shanghai, 200080 China.
    Background: Preoperative treatment of anti-vascular endothelial growth factor (VEGF) agents is extensively used in proliferative diabetic retinopathy (PDR), but the molecular mechanism is not fully understood. The objective of this research is to observe change of protein profile induced by ranibizumab (an anti-VEGF agent) in vitreous humor from PDR patients and reveal the effects of anti-VEGF treatment on PDR.

    Methods: A proteomic method was used to identify differentially expressed proteins in vitreous humor. Read More

    Exocrine Dysfunction Correlates with Endocrinal Impairment of Pancreas in Type 2 Diabetes Mellitus.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):121-125
    Department of Microbiology, JSS Medical College, JSS University, Mysore, Karnataka, India.
    Background: Diabetes mellitus (DM) is a chronic abnormal metabolic condition, which manifests elevated blood sugar level over a prolonged period. The pancreatic endocrine system generally gets affected during diabetes, but often abnormal exocrine functions are also manifested due to its proximity to the endocrine system. Fecal elastase-1 (FE-1) is found to be an ideal biomarker to reflect the exocrine insufficiency of the pancreas. Read More

    Diabetic Retinopathy Awareness and Associations with Multiple Comorbidities: Insights from DIAMOND Study.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):30-35
    Chairman and Medical Director, Aditya Jyot Eye Hospital Pvt. Ltd., Mumbai, Maharashtra, India.
    Background: Diabetic retinopathy (DR) is leading cause of visual impairment in working-age adults. Macular edema can occur with or without other signs of retinopathy.

    Methods: This was a single-center, retrospective study conducted over 2 years in patients (>40 years of age) having type 2 diabetes mellitus (T2DM). Read More

    Vitamin D deficiency is associated with poorer satisfaction with diabetes-related treatment and quality of life in patients with type 2 diabetes: a cross-sectional study.
    Health Qual Life Outcomes 2018 Mar 12;16(1):44. Epub 2018 Mar 12.
    Department of Endocrinology and Nutrition, Health Sciences Research Institute Germans Trias i Pujol, 08916, Badalona, Spain.
    Background: In this cross-sectional study, we assessed the possible association of vitamin D deficiency with self-reported treatment satisfaction and health-related quality of life in patients with type 2 diabetes.

    Methods: We performed a sub-analysis of a previous study and included a total of 292 type 2 diabetic patients. We evaluated treatment satisfaction and health-related quality of life through specific tools: the Diabetes Treatment Satisfaction Questionnaire and the Audit of Diabetes-Dependent Quality of Life. Read More

    Complement C3 and Risk of Diabetic Microvascular Disease: A Cohort Study of 95202 Individuals from the General Population.
    Clin Chem 2018 Mar 9. Epub 2018 Mar 9.
    Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Herlev, Denmark.
    Background: Whether the complement system is involved in the development of diabetic microvascular disease is unknown. We tested the hypothesis that high concentrations of complement C3 are associated with increased risk of diabetic retinopathy, nephropathy, and neuropathy in individuals from the general population.

    Methods: We studied 95202 individuals from the general population with baseline measurements of complement C3, genotyped for rs1065489, rs429608, and rs448260 determining concentrations of complement C3, and enrolled in the Copenhagen General Population Study from 2003 through 2013, following them until April 10, 2013. Read More

    Association of serum vitamin D levels and diabetic retinopathy in Asian Indians with type 2 diabetes.
    Diabetes Res Clin Pract 2018 Mar 5;139:308-313. Epub 2018 Mar 5.
    Emory University School of Medicine, Atlanta, GA, United States. Electronic address:
    Background: Vitamin D deficiency (VDD) is a condition that has been associated with diabetic retinopathy (DR) in various populations, but has not been studied in Asian Indians.

    Aims: To evaluate the association of serum 25-hydroxyvitamin D (25(OH)D) levels with presence and severity of DR among Asian Indians with type 2 diabetes.

    Methods: We collected information on individuals with type 2 diabetes that received care at a tertiary diabetes centre in India, between 2012 and 2015. Read More

    Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.
    Lancet Diabetes Endocrinol 2018 May 5;6(5):361-369. Epub 2018 Mar 5.
    Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. Electronic address:
    Background: Diabetes is presently classified into two main forms, type 1 and type 2 diabetes, but type 2 diabetes in particular is highly heterogeneous. A refined classification could provide a powerful tool to individualise treatment regimens and identify individuals with increased risk of complications at diagnosis.

    Methods: We did data-driven cluster analysis (k-means and hierarchical clustering) in patients with newly diagnosed diabetes (n=8980) from the Swedish All New Diabetics in Scania cohort. Read More

    HbA1c levels in children with type 1 diabetes and correlation to diabetic retinopathy.
    J Pediatr Endocrinol Metab 2018 Mar;31(4):369-374
    Department of Pediatrics, Helsingborg Hospital, Lund University, Helsingborg, Sweden.
    Background: Type 1 diabetes mellitus (T1D) is a metabolic disease causing hyperglycemia due to β-cell destruction. Despite adequate treatment, complications such as diabetic retinopathy (DR) are common. The first aim was to investigate if acute onset of type 1 diabetes differed between those who had developed retinopathy and who had not after 15 years from diagnosis. Read More

    Quantitative evaluation of early retinal changes in children with type 1 diabetes mellitus without retinopathy.
    Clin Exp Optom 2018 Feb 28. Epub 2018 Feb 28.
    Department of Pediatric Endocrinology, Dr. Sami Ulus Children's Health and Disease Training and Research Hospital, Ankara, Turkey.
    Background: To investigate whether abnormal glucose metabolism and duration of diabetes mellitus (DM) caused the thinning in retinal layers in children with type 1 DM without retinopathy by using spectral domain optical coherence tomography (SD-OCT) and to compare the results obtained with those in healthy children.

    Methods: This cross-sectional prospective study included 73 patients with type 1 DM (DM group) and 62 age-matched control subjects (control group). The duration of DM and the glycosylated haemoglobin (HbA1c) levels of the diabetic children were recorded. Read More

    Treating Diabetic Macular Oedema (DMO): real world UK clinical outcomes for the 0.19mg Fluocinolone Acetonide intravitreal implant (Iluvien™) at 2 years.
    BMC Ophthalmol 2018 Feb 27;18(1):62. Epub 2018 Feb 27.
    Ophthalmology Department, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHSFT, Mindelsohn Way, Birmingham, B15 2TH, United Kingdom.
    Background: To compare visual function and structural improvements in pseudophakic eyes with diabetic macular oedema (DMO) treated with the 0.19mg Fluocinolone Acetonide (FAc) intravitreal implant (Iluvien) in a 'real world' setting.

    Methods: A single centre retrospective evaluation of patients with DMO unresponsive to conventional treatment treated with the FAc implant according to UK guidelines. Read More

    Interaction of renin-angiotensin system gene polymorphisms with hypertension in Chinese patients with type 1 diabetes and retinopathy.
    Oncotarget 2018 Jan 9;9(7):7582-7589. Epub 2018 Jan 9.
    Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
    Background: The objective of this research was to investigate the interaction of RAS gene polymorphisms in Chinese patients with type 1 diabetes mellitus (T1DM) and diabetic retinopathy (DR).

    Methods: Genomic DNA was extracted from peripheral blood leukocytes and genotyping for the angiotensin converting enzyme (ACE) gene I/D and angiotensinogen (AGT) gene M/T polymorphisms was performed using the polymerase chain reaction method. 311 T1DM patients were recruited for the assessment of ACE and AGT polymorphisms relating to DR. Read More

    The prevalence and risk factors of peripheral neuropathy among patients with type 2 diabetes mellitus; the case of Jordan.
    Diabetol Metab Syndr 2018 21;10. Epub 2018 Feb 21.
    1National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, P.O Box 13165, Amman, 11942 Jordan.
    Background: Peripheral neuropathy is one of the most common microvascular complication of diabetes mellitus. This study is conducted to determine the prevalence of diabetic peripheral neuropathy (DPN) and its associated factors among patients with type 2 diabetes mellitus in Jordan.

    Methods: A cross-sectional study was conducted at the National Center for Diabetes, Endocrinology and Genetics, Jordan. Read More

    P66Shc expression in diabetic rat retina.
    BMC Ophthalmol 2018 Feb 27;18(1):58. Epub 2018 Feb 27.
    Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
    Background: P66Shc is partially localised within the mitochondrial fraction. It is primarily related to the generation of mitochondrial reactive oxygen species and apoptosis. Based on previous studies, we hypothesize that in the retina, p66Shc may exist and affect the development of diabetic retinopathy. Read More

    Neuroprotective strategies for retinal disease.
    Prog Retin Eye Res 2018 Feb 23. Epub 2018 Feb 23.
    Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA, 30033, USA.
    Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of sight affects patient quality of life and puts an economic burden both on individuals and the greater healthcare system. Read More

    Neutrophil-to-lymphocyte ratio and microvascular complications in subjects with type 2 diabetes: Pakistan’s perspective
    Turk J Med Sci 2018 Feb 23;48(1):157-161. Epub 2018 Feb 23.
    Background/aim: The aim of this study is to find the association between diabetic microvascular complications and the neutrophil-to-lymphocyte ratio (NLR) in subjects with type 2 diabetes. Materials and methods: This was a retrospective study based on hospital data records from January 2005 to May 2016 at the Baqai Institute of Diabetology and Endocrinology. The eligibility criteria included subjects with type 2 diabetes with their latest complete blood count while subjects with conditions such as chronic inflammation, cancer, heart failure, and end-stage renal disease were not eligible for inclusion. Read More

    Long-term visit-to-visit glycemic variability as predictor of micro- and macrovascular complications in patients with type 2 diabetes: The Rio de Janeiro Type 2 Diabetes Cohort Study.
    Cardiovasc Diabetol 2018 Feb 24;17(1):33. Epub 2018 Feb 24.
    Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rua Croton, 72, Jacarepagua, Rio de Janeiro, RJ, CEP: 22750-240, Brazil.
    Background: Long-term visit-to-visit glycemic variability is an additional measure of glycemic control. We aimed to evaluate the prognostic value of several measures of glycemic variability for the occurrence of micro- and macrovascular complications, and all-cause mortality in patients with type 2 diabetes.

    Methods: 654 individuals were followed-up over a median of 9. Read More

    Effects of Diets with Different Proportions of Protein/Carbohydrate on Retinal Manifestations in Mice.
    In Vivo 2018 Mar-Apr;32(2):265-272
    Department of Hygiene and Health Promotion Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Background/aim: Diabetic nephropathy is aggravated by a higher intake of total protein. The effects of diets with different proportions of protein and carbohydrate on diabetic retinopathy in db mice, a type-2 diabetes animal model, were examined, as well as diabetic nephropathy.

    Materials And Methods: Control and db mice at 5 weeks of age were fed the diets (% energy of protein/carbohydrate/fat; L-diet: 12/71/17; H-diet: 24/59/17) under ad libitum conditions and pair-feeding conditions for 6 weeks, respectively. Read More

    Diabetic Complications and Insight into Antidiabetic Potentialities of Ethno-medicinal Plants: A review.
    Recent Pat Inflamm Allergy Drug Discov 2018 Feb 21. Epub 2018 Feb 21.
    Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N.L., CP 64849. Mexico.
    Background: The naturally inspired treatment options for several disease conditions and human-health related disorders such as diabetes mellitus have gained considerable research interest. In this context, naturally occurring plants and herbs with medicinal functionalities have gained special place than ever before in the current medicinal world.

    Objective: The objective of this review is to extend the current knowledge in the clinical field related to the diabetic complications. Read More

    A Clinical Decision Support System for Diabetic Retinopathy Screening: Creating a Clinical Support Application.
    Telemed J E Health 2018 Feb 21. Epub 2018 Feb 21.
    2 Department of Computer Engineering and Mathematics, Universitat Rovira i Virgili , Reus, Spain .
    Background: The aim of this study was to build a clinical decision support system (CDSS) in diabetic retinopathy (DR), based on type 2 diabetes mellitus (DM) patients.

    Method: We built a CDSS from a sample of 2,323 patients, divided into a training set of 1,212 patients, and a testing set of 1,111 patients. The CDSS is based on a fuzzy random forest, which is a set of fuzzy decision trees. Read More

    Genetic basis of diabetic kidney disease and other diabetic complications.
    Curr Opin Genet Dev 2018 Feb 13;50:17-24. Epub 2018 Feb 13.
    Folkhälsan Institute of Genetics, Folkhälsan Research Center, 00290 Helsinki, Finland; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
    Diabetic kidney disease and other long-term complications are common in diabetes, and comprise the main cause of co-morbidity and premature mortality in individuals with diabetes. While familial clustering and heritability have been reported for all diabetic complications, the genetic background and the molecular mechanisms remain poorly understood. In recent years, genome-wide association studies have identified a few susceptibility loci for the renal complications as well as for diabetic retinopathy, diabetic cardiovascular disease and mortality. Read More

    Diabetic Retinopathy Awareness among Diabetic Patients Attending COMS-TH.
    Kathmandu Univ Med J (KUMJ) 2017 Jan.-Mar.;15(57):79-83
    Department of Ophthalmology, College of Medical Science-Teaching Hospital, Bharatpur, Nepal.
    Background Diabetic retinopathy (DR) is one of the leading causes of blindness in Nepal. Objective The main objective of the study is to know the awareness of diabetic retinopathy among new cases of diabetes mellitus (DM) attending the college of medical science- teaching hospital, Bharatpur, Nepal. Method All the diabetic cases referred for ophthalmic consultation and also referred outpatient department cases from other departments to ophthalmic outpatient department was carried out. Read More

    Gender Difference in the Association of Early- vs. Late-Onset Type 2 Diabetes with Non-Fatal Microvascular Disease in China: A Cross-sectional Study.
    Front Endocrinol (Lausanne) 2018 31;9:15. Epub 2018 Jan 31.
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
    Background: This study aimed to test whether early-onset (defined as <40 years of age) type 2 diabetes mellitus (T2DM) imparted different risks of microvascular disease to Chinese men and women.

    Methods: 222,537 Chinese patients with T2DM were recruited in 630 hospitals from 106 cities in 30 provinces of China in 2012 using a cross-sectional design. Logistic regression analysis was performed to obtain odds ratios (ORs) of male vs. Read More

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