4,164 results match your criteria Retinopathy Diabetic Background


Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history.

Diabetol Metab Syndr 2020 2;12:55. Epub 2020 Jul 2.

Department of Endocrinology and Metabolism, The Second People's Hospital of Yunnan Province, Fourth Affiliated Hospital of Kunming Medical University, Kunming, 650021 China.

Background: Diabetic retinopathy (DR) is a specific neurovascular complication of diabetes mellitus (DM). Clinically, family history is a widely recognized risk factor for DR, assisting diagnosis and risk strata. However, among a great amount of DR patients without hereditary history like hypertension and diabetes, direct and simple risk factors to assist clinical decisions are still required. Read More

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http://dx.doi.org/10.1186/s13098-020-00562-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331251PMC

Prevalence of Diabetic Retinopathy and Its Associated Factors among Diabetic Patients at Debre Markos Referral Hospital, Northwest Ethiopia, 2019: Hospital-Based Cross-Sectional Study.

Diabetes Metab Syndr Obes 2020 24;13:2179-2187. Epub 2020 Jun 24.

Department of Biomedical Sciences (Medical Physiology), College of Medicine and Health Sciences, Debre Tabur University, Debre Tabur, Ethiopia.

Background: Diabetic retinopathy is a well-known sight-threatening microvascular complication of diabetes mellitus. Currently, 93 million people live with diabetic retinopathy worldwide. There are insufficient studies addressing the prevalence of diabetic retinopathy and risk factors in Ethiopia. Read More

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http://dx.doi.org/10.2147/DMSO.S260694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328291PMC

Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein occlusion.

Cochrane Database Syst Rev 2020 Jul 7;7:CD009510. Epub 2020 Jul 7.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Background: Branch retinal vein occlusion (BRVO) is one of the most commonly occurring retinal vascular abnormalities. The most common cause of visual loss in people with BRVO is macular oedema (MO). Grid or focal laser photocoagulation has been shown to reduce the risk of visual loss. Read More

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http://dx.doi.org/10.1002/14651858.CD009510.pub3DOI Listing

Comparison of smartphone-based retinal imaging systems for diabetic retinopathy detection using deep learning.

BMC Bioinformatics 2020 Jul 6;21(Suppl 4):259. Epub 2020 Jul 6.

Dept. of Computer Science, University of Central Arkansas, 201 Donaghey Ave, Conway, AR, 72035, USA.

Background: Diabetic retinopathy (DR), the most common cause of vision loss, is caused by damage to the small blood vessels in the retina. If untreated, it may result in varying degrees of vision loss and even blindness. Since DR is a silent disease that may cause no symptoms or only mild vision problems, annual eye exams are crucial for early detection to improve chances of effective treatment where fundus cameras are used to capture retinal image. Read More

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http://dx.doi.org/10.1186/s12859-020-03587-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336606PMC

Relationships between microvascular complications of diabetes mellitus and levels of macro and trace elements.

Minerva Endocrinol 2020 Jul 3. Epub 2020 Jul 3.

Internal Medicine, Girne Univercıty, Kuzey Kıbrıs Türk Cumhuriyeti, Ciprus.

Background: The aim of this study was to determine relationships between microvascular complications of type 2 diabetes mellitus (T2DM) and trace element levels measured by ICP-MS.

Methods: One hundred eighteen patients with T2DM, ages 30-65 years, and 40 control subjects were included in the study. The T2DM patients were divided into three groups according to their types of microvascular complications. Read More

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http://dx.doi.org/10.23736/S0391-1977.20.03139-9DOI Listing

MicroRNA-199a-3p inhibits angiogenesis by targeting the VEGF/PI3K/AKT signalling pathway in an in vitro model of diabetic retinopathy.

Exp Mol Pathol 2020 Jul 1:104488. Epub 2020 Jul 1.

Department of Ophthalmology, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, PR China. Electronic address:

Background: Diabetic retinopathy (DR) is a major inducer of blindness and visual impairment. As a critical cause for DR, hyperglycaemia is able to trigger multiple biochemical alterations. MiRNAs, which contain various functions, can effectively regulate blood glucose levels. Read More

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http://dx.doi.org/10.1016/j.yexmp.2020.104488DOI Listing

Optical coherence tomography features of neovascularization in proliferative diabetic retinopathy: a systematic review.

Int J Retina Vitreous 2020 29;6:26. Epub 2020 Jun 29.

Department of Ophthalmology, Centro Hospitalar Universitário de Lisboa Norte, EPE-Hospital de Santa Maria, Avenida Professor Egas Moniz, 1649-035 Lisbon, Portugal.

Background: Diabetic retinopathy (DR) is a leading cause of blindness due to diabetic macular edema (DME) or complications of proliferative diabetic retinopathy (PDR). Optical coherence tomography (OCT) is a noninvasive imaging technique well established for DME but less used to assess neovascularization in PDR. Developments in OCT imaging and the introduction of OCT angiography (OCTA) have shown significant potential in PDR. Read More

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http://dx.doi.org/10.1186/s40942-020-00230-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322867PMC

Factors Associated with Untreated Depression Among Type 2 Diabetic Patients at Halaba Kulito Hospital, South Ethiopia: A Cross-Sectional Study.

Diabetes Metab Syndr Obes 2020 24;13:2189-2198. Epub 2020 Jun 24.

Department of Anesthesia, College of Health Science and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Background: Depressed type 2 diabetes mellitus patients (T2DM) show poorer compliance with treatment and self-care recommendations than non-depressed T2DM patients. This contributes to poor prognosis and accelerates diabetic-related complications including poor glucose regulation, diabetic retinopathy, neuropathy, nephropathy, and escalated healthcare expenditure.

Objective: This study aimed to determine the magnitude of untreated depression and associated factors among people living with T2DM at outpatient diabetic clinic in Halaba Kulito General Hospital, Southern Ethiopia. Read More

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http://dx.doi.org/10.2147/DMSO.S255360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323570PMC

Prospective evaluation of an artificial intelligence-enabled algorithm for automated diabetic retinopathy screening of 30 000 patients.

Br J Ophthalmol 2020 Jun 30. Epub 2020 Jun 30.

Population Health Research Institute, St George's, University of London, London, UK

Background/aims: Human grading of digital images from diabetic retinopathy (DR) screening programmes represents a significant challenge, due to the increasing prevalence of diabetes. We evaluate the performance of an automated artificial intelligence (AI) algorithm to triage retinal images from the English Diabetic Eye Screening Programme (DESP) into test-positive/technical failure versus test-negative, using human grading following a standard national protocol as the reference standard.

Methods: Retinal images from 30 405 consecutive screening episodes from three English DESPs were manually graded following a standard national protocol and by an automated process with machine learning enabled software, EyeArt v2. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316594DOI Listing

Elevated vitreous Lipocalin-2 levels of patients with proliferative diabetic retinopathy.

BMC Ophthalmol 2020 Jun 30;20(1):260. Epub 2020 Jun 30.

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, China.

Background: Lipocalin-2 (LCN2) is a novel adipokine with potential roles in obesity, insulin resistance, and inflammation. This study aims to assess the concentrations of LCN2 and vascular endothelial growth factor (VEGF) expressed in the vitreous humors of patients with proliferative diabetic retinopathy (PDR).

Methods: The concentrations of LCN2 and VEGF were measured from the vitreous of 67 patients undergoing vitrectomy (20 controls and 47 PDR) via enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.1186/s12886-020-01462-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329527PMC

Clinical Utilization Pattern of Multiple Strengths of Glimepiride and Metformin Fixed Dose Combinations in Indian Type 2 Diabetes Patients.

J Assoc Physicians India 2020 Jul;68(7):57-61

Vice President, Scientific Services, USV Private Limited, Mumbai, Maharashtra.

Background: In Indian clinical set-up, modern sulfonylurea, particularly glimepiride is still preferred as an add-on to metformin due to its efficacy, safety and cost effectiveness. In view of this, a case-based questionnaire survey was conducted to analyze the clinical utility of multiple strengths of glimepiride and metformin fixed dose combination in type 2 diabetes mellitus (T2DM).

Methods: The case-based questionnaire survey was conducted with 174 health care professionals across India to assess the use of glimepiride and metformin fixed dose combination according to age, duration of diabetes, body mass index (BMI), diabetes complications, concomitant medications like insulin, and statin. Read More

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Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis.

Ann Intern Med 2020 Jun 30. Epub 2020 Jun 30.

Clinical Research and Evidence-Based Medicine Unit and Diabetes Centre, Aristotle University of Thessaloniki, Thessaloniki, Greece (E.B.).

Background: Several pharmacologic options for type 2 diabetes are available.

Purpose: To compare benefits and harms of glucose-lowering drugs in adults with type 2 diabetes.

Data Sources: Several databases from inception through 18 December 2019 and ClinicalTrials. Read More

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http://dx.doi.org/10.7326/M20-0864DOI Listing

An evidence map of clinical practice guideline recommendations and quality on diabetic retinopathy.

Eye (Lond) 2020 Jun 24. Epub 2020 Jun 24.

Evidence-Based Nursing Center, School of Nursing, Lanzhou University, Lanzhou City, Gansu Province, China.

To present an evidence map for explicating research trends and gaps, we systematically review clinical practice guidelines (CPGs) on diabetic retinopathy (DR) and assess the quality of CPGs and consistency of recommendations. A literature search was performed in PubMed, Embase, Web of Science, CPG databases, and website of diabetes society to include the CPGs. The basic information, methodological quality, and reporting quality of CPGs, recommendations for DR were exacted by the Excel 2013. Read More

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http://dx.doi.org/10.1038/s41433-020-1010-1DOI Listing

A robust method for the automatic location of the optic disc and the fovea in fundus images.

Comput Methods Programs Biomed 2020 Jun 12;196:105599. Epub 2020 Jun 12.

Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Paseo Belén 15, Valladolid 47011, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain; Instituto de Investigación en Matemáticas (IMUVA), Universidad de Valladolid, Valladolid 47011, Spain.. Electronic address:

Background And Objective: The location of the optic disc (OD) and the fovea is usually crucial in automatic screening systems for diabetic retinopathy. Previous methods aimed at their location often fail when these structures do not have the standard appearance. The purpose of this work is to propose novel, robust methods for the automatic detection of the OD and the fovea. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105599DOI Listing

Vitamin A and fish oils for preventing the progression of retinitis pigmentosa.

Cochrane Database Syst Rev 2020 06 18;6:CD008428. Epub 2020 Jun 18.

Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA.

Background: Retinitis pigmentosa (RP) comprises a group of hereditary eye diseases characterized by progressive degeneration of retinal photoreceptors. It results in severe visual loss that may lead to blindness. Symptoms may become manifest during childhood or adulthood which include poor night vision (nyctalopia) and constriction of peripheral vision (visual field loss). Read More

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http://dx.doi.org/10.1002/14651858.CD008428.pub3DOI Listing

Deep Learning-Based Detection of Pigment Signs for Analysis and Diagnosis of Retinitis Pigmentosa.

Sensors (Basel) 2020 Jun 18;20(12). Epub 2020 Jun 18.

Division of Electronics and Electrical Engineering, Dongguk University, 30 Pildong-ro 1-gil, Jung-gu, Seoul 04620, Korea.

Ophthalmological analysis plays a vital role in the diagnosis of various eye diseases, such as glaucoma, retinitis pigmentosa (RP), and diabetic and hypertensive retinopathy. RP is a genetic retinal disorder that leads to progressive vision degeneration and initially causes night blindness. Currently, the most commonly applied method for diagnosing retinal diseases is optical coherence tomography (OCT)-based disease analysis. Read More

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http://dx.doi.org/10.3390/s20123454DOI Listing

Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications.

J Immunol Res 2020 28;2020:9680508. Epub 2020 May 28.

College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China.

Chlorogenic acid (CA) is a phenolic compound commonly found in human plant-based diets. CA is the main component of many traditional Chinese medicine preparations, and in recent years, it has been found to have hypoglycemic, hypolipidemic, anti-inflammatory, antioxidant, and other pharmacological properties. Specifically, CA relieves the effects of, and prevents, diabetes mellitus (DM). Read More

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http://dx.doi.org/10.1155/2020/9680508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275206PMC

Association of transcription factor 7-like 2 (rs7903146) gene polymorphism with diabetic retinopathy.

Ophthalmic Genet 2020 Jun 21:1-7. Epub 2020 Jun 21.

Department of Clinical Pathology, Faculty of Medicine, Mansoura University , Mansoura, Egypt.

Background: Diabetic retinopathy (DR) is one of the most common diabetic complications. Genetic factors play an important role in the development and progression of DR. So, the present study aimed to investigate the association of (rs7903146) gene polymorphism with the risk of DR in type1 and type2 DM (T1DM and T2DM) in the Egyptian population. Read More

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http://dx.doi.org/10.1080/13816810.2020.1780620DOI Listing

Altered resting cerebral blood flow specific to patients with diabetic retinopathy revealed by arterial spin labeling perfusion magnetic resonance imaging.

Acta Radiol 2020 Jun 17:284185120932391. Epub 2020 Jun 17.

Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China.

Background: Previous neuroimaging studies have shown that patients with diabetic retinopathy (DR) were accompanied by abnormalities in cerebral functional and structural architecture, whereas the resting cerebral blood flow (CBF) alterations in patients with DR are not well understood.

Purpose: To explore CBF alterations in patients with DR using pseudo-continuous arterial spin labeling (pCASL) imaging.

Material And Methods: Thirty-one individuals with DR (15 men, 16 women; mean age = 53. Read More

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http://dx.doi.org/10.1177/0284185120932391DOI Listing

Hyperoside Ameliorates Diabetic Retinopathy Anti-Oxidation, Inhibiting Cell Damage and Apoptosis Induced by High Glucose.

Front Pharmacol 2020 29;11:797. Epub 2020 May 29.

Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China.

Background: Hyperoside (Hyp) is a flavonoid substance extracted from plants, which has the functions of anti-cancer, anti-inflammatory, and anti-oxidation. In the previous study, we found that Hyp reduced the injury of rat retinal vascular endothelial cells (RVECs) induced by HO.

Method: In the present research, we evaluated the protective effect of Hyp on the pathological damage of retina caused by high glucose of diabetes mellitus (DM) in and experiments. Read More

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http://dx.doi.org/10.3389/fphar.2020.00797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273924PMC

Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study.

Diabetes Metab Syndr Obes 2020 28;13:1863-1872. Epub 2020 May 28.

Department of Biostatistics, Physiotherapy Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Increase in the prevalence of type 2 diabetic mellitus (T2DM) as a complex disease, its complications, and spread has become a dominant global health threat in recent decades.

Objective: The aim of the current study was to investigate the impact of risk factors and transition probability on the development and progression of the late complications of T2DM.

Methods: This study was an open cohort one which was conducted at Isfahan Endocrine and Metabolism Research Center (IEMRC). Read More

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http://dx.doi.org/10.2147/DMSO.S234563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266524PMC

Serum CA125 Level Is Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes.

Diabetes Metab Syndr Obes 2020 22;13:1803-1812. Epub 2020 May 22.

Department of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, People's Republic of China.

Background: To investigate the association between serum carbohydrate antigen 125 (CA125) and the presence as well as severity of diabetes retinopathy (DR) in Chinese adult patients with type 2 diabetes.

Methods: A hospital-based cross-sectional study was conducted from February 2012 to November 2018. DR was assessed using Early Treatment Diabetic Retinopathy Study criteria. Read More

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http://dx.doi.org/10.2147/DMSO.S250928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250309PMC

Oxidative Stress Induces a VEGF Autocrine Loop in the Retina: Relevance for Diabetic Retinopathy.

Cells 2020 Jun 11;9(6). Epub 2020 Jun 11.

Department of Biology, University of Pisa, 56126 Pisa, Italy.

Background: Oxidative stress (OS) plays a central role in diabetic retinopathy (DR), triggering expression and release of vascular endothelial growth factor (VEGF), the increase of which leads to deleterious vascular changes. We tested the hypothesis that OS-stimulated VEGF induces its own expression with an autocrine mechanism.

Methods: MIO-M1 cells and ex vivo mouse retinal explants were treated with OS, with exogenous VEGF or with conditioned media (CM) from OS-stressed cultures. Read More

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http://dx.doi.org/10.3390/cells9061452DOI Listing

Follow-Up Compliance for Patients Diagnosed with Diabetic Retinopathy After Teleretinal Imaging in Primary Care.

Telemed J E Health 2020 Jun 15. Epub 2020 Jun 15.

Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Teleretinal imaging has been demonstrated to increase diabetic patient compliance with annual retinal examinations, but few studies have examined patient behavior after screening. Compliance with eye specialist follow-up is critical to ensure remote detection programs improve long-term vision outcomes for patients with diabetes. The purpose of this study was to assess the rate of eye specialist follow-up compliance after referral for diabetic retinopathy (DR) from a teleretinal imaging program in a large primary care group practice. Read More

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http://dx.doi.org/10.1089/tmj.2019.0264DOI Listing

Retinal blood oxygen saturation and vascular endothelial growth factor-A in early diabetic retinopathy: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(24):e20562

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Diabetic retinopathy (DR) remains the most common microvascular complication of diabetes; both its high prevalence and associated high risk of vision loss lead it to the major global health burden. Despite significant research efforts, there still remains much of the underlying pathology not fully understand. In the past studies, inner retinal blood flow disturbances are widely assessed as a potential biomarker of DR. Read More

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http://dx.doi.org/10.1097/MD.0000000000020562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302675PMC

Relationship between Clinical Features of Diabetic Retinopathy and Systemic Factors in Patients with Newly Diagnosed Type II Diabetes Mellitus.

J Korean Med Sci 2020 Jun 15;35(23):e179. Epub 2020 Jun 15.

Department of Ophthalmology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.

Background: We investigated the relationship between clinical features of diabetic retinopathy (DR) and systemic factors in patients with newly diagnosed type II diabetes mellitus (T2DM).

Methods: Retrospective review of newly diagnosed T2DM-patients who underwent complete ophthalmic examinations at the time of T2DM diagnosis were conducted. We reviewed DM related systemic factor data and investigated systemic factors related to the presence of DR at T2DM diagnosis. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295598PMC

Epidemiology of visual impairment, sight-threatening or treatment-requiring diabetic eye disease in children and young people in the UK: findings from DECS.

Br J Ophthalmol 2020 Jun 14. Epub 2020 Jun 14.

Great Ormond Street Institute of Child Health, University College London, London, UK

Background: We investigated the incidence and causes of sight-threatening diabetes-related eye disease in children living with diabetes in the UK, to inform the national eye screening programme and enable monitoring of trends.

Methods: We undertook a prospective active national surveillance via the British Ophthalmic Surveillance Unit. Eligible cases were children aged 18 years or younger, with type 1 or 2 diabetes, newly diagnosed between January 2015 and February 2017 with sight-threatening diabetic eye disease. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315886DOI Listing

Changes in choroidal thickness in advanced diabetic retinopathy treated with pan-retinal photocoagulation using a pattern scanning laser versus a conventional laser.

BMC Ophthalmol 2020 Jun 12;20(1):226. Epub 2020 Jun 12.

Department of Ophthalmology, College of Medicine, Chung-Ang University Hospital, 102 Heukseok-ro, Dongjak-gu, Seoul, 06974, South Korea.

Background: To compare the effect of pan-retinal photocoagulation (PRP) using pattern scanning or conventional laser on subfoveal choroidal thickness (SFChT).

Methods: Thirty-eight patients (64 eyes) with advanced diabetic retinopathy (DR) who underwent PRP using pattern scanning or conventional laser were included. Changes in SFChT were compared with baseline values at 1, 3, 6, and 12 months after PRP using swept-source optical coherence tomography. Read More

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http://dx.doi.org/10.1186/s12886-020-01501-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291646PMC

Plasma angiogenesis and oxidative stress markers in patients with diabetic retinopathy.

Biomarkers 2020 Jul 12;25(5):397-401. Epub 2020 Jun 12.

Department of Medicine, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Neovascularization in the retina and hyperglycaemia-induced oxidative stress are implicated in the pathogenesis of diabetic retinopathy (DR). In this study, we hypothesized that the plasma angiogenic and oxidative stress markers associated with these derangements could aid in the screening of diabetic patients who are at an increased risk of developing retinopathy. This study included normal ( = 148), type2 diabetes without retinopathy (DNR;  = 148), proliferative DR (PDR;  = 74) and non-PDR (NPDR;  = 148) subjects. Read More

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http://dx.doi.org/10.1080/1354750X.2020.1774654DOI Listing

Microaneurysms visualisation using five different optical coherence tomography angiography devices compared to fluorescein angiography.

Br J Ophthalmol 2020 Jun 11. Epub 2020 Jun 11.

Eye Clinic, Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, Milano, Italy.

Background: To compare fluorescein angiography (FA) and five different optical coherence tomography angiography (OCTA) devices and to test their reproducibility in the evaluation of retinal microaneurysms (MAs) secondary to diabetic retinopathy (DR).

Methods: On the same day, patients with DR were imaged with FA and five OCTA devices: prototype Spectralis OCTA, prototype PlexElite, RTVue XR Avanti, AngioPlex and DRI OCT Triton. For all OCTA devices, a 3×3 volume scan pattern was performed. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316817DOI Listing

Patient Satisfaction Toward a Tele-Retinal Screening Program in Endocrinology Clinics at a Tertiary Hospital in Riyadh, Saudi Arabia.

Cureus 2020 May 6;12(5):e7986. Epub 2020 May 6.

Ophthalmology, Princess Nourah Bint Abdulrahman University (PNU), Riyadh, SAU.

Purpose: Tele-retinal screening programs use a nonmydriatic camera for retinal imaging. These images are reviewed by ophthalmologists, for interpretation and planning of appropriate treatment and follow up. Patient satisfaction is a critical tool to assess the quality of healthcare delivery and to reframe the current screening programs. Read More

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http://dx.doi.org/10.7759/cureus.7986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273468PMC

Visual and anatomic outcomes of sustained single agent anti-VEGF treatment versus double anti-VEGF switching in the treatment of persistent diabetic macular edema.

Int J Retina Vitreous 2020 8;6:17. Epub 2020 Jun 8.

New England Eye Center, Tufts Medical Center, Tufts University, Boston, MA USA.

Background: To compare the anatomical and visual outcomes in eyes with persistent diabetic macular edema (DME) after initial anti-VEGF therapy that were retreated continuously with the same anti-VEGF drug versus those that underwent two successive cycles of medication change in anti-VEGF drugs (double anti-VEGF switch).

Methods: Retrospective review of eyes with persistent DME after 3 initial consecutive monthly anti-VEGF injections. This cohort was divided into two groups: Group 1 continued to receive the same initial anti-VEGF drug for at least 18 months while group 2 eyes were switched to different anti-VEGF medications twice. Read More

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http://dx.doi.org/10.1186/s40942-020-00220-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278067PMC

Ten-year incidence and assessment of safe screening intervals for diabetic retinopathy: the OPHDIAT study.

Br J Ophthalmol 2020 Jun 10. Epub 2020 Jun 10.

Ophthalmology Department, Assistance Publique des Hôpitaux de Paris, Paris, France.

Background: To estimate the 10-year incidence of referable diabetic retinopathy (DR) in a French population with type 1 and 2 diabetes mellitus (DM). A secondary objective was the assessment of safe screening intervals in patients with diabetes without retinopathy.

Methods: Observational, prospective and multicentric study between June 2004 and September 2017 based on a regional screening programme for DR in the Paris region. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316030DOI Listing

Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography.

Eye Vis (Lond) 2020 1;7:29. Epub 2020 Jun 1.

Department of Ophthalmology, New England Eye Center, Tufts Medical Center, 800 Washington Street, Box 450, Boston, MA 02111 USA.

Background: To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities (IRMAs) in response to anti-vascular endothelial growth factor (anti-VEGF) treatment, documented by optical coherence tomography angiography (OCTA) in diabetic eyes.

Methods: In this retrospective study, IRMAs were evaluated with multimodal imaging (fundus photography, fluorescein angiography, OCTA) in treatment-naïve diabetic eyes before and after anti-VEGF treatment for diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR) and compared to diabetic control eyes with similar diabetic retinopathy (DR) severity that did not receive anti-VEGF therapy. The morphological characteristics of IRMAs on enface OCTA imaging were graded by masked readers at baseline, then after anti-VEGF therapy in treated eyes or after observation in control eyes. Read More

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http://dx.doi.org/10.1186/s40662-020-00195-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262762PMC

Personalising screening of sight-threatening diabetic retinopathy - qualitative evidence to inform effective implementation.

BMC Public Health 2020 Jun 8;20(1):881. Epub 2020 Jun 8.

Eye and Vision Science, University of Liverpool and St. Paul's Eye Unit, Royal Liverpool University Hospital, Preston, UK.

Background: Internationally, systematic screening for sight-threatening diabetic retinopathy (STDR) usually includes annual recall. Researchers and policy-makers support extending screening intervals, citing evidence from observational studies with low incidence rates. However, there is little research around the acceptability to people with diabetes (PWD) and health care professionals (HCP) about changing eye screening intervals. Read More

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http://dx.doi.org/10.1186/s12889-020-08974-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278114PMC

The relationship of central corneal thickness with the status of diabetic retinopathy.

BMC Ophthalmol 2020 Jun 8;20(1):220. Epub 2020 Jun 8.

Department of Ophthalmology, Acibadem Adana Hospital, Adana, Turkey.

Background: To compare central corneal thickness (CCT) values measured by three different devices: slit-scanning topography (SST), ultrasonic pachymetry (UP), and optical coherence tomography (OCT) in diabetic eyes and compare the CCT values in patients with and without diabetic retinopathy.

Methods: Ninety-six patients with diabetes mellitus were included in this prospective study and divided into two groups according to the presence of diabetic retinopathy, as Group I with retinopathy and Group II without. The CCT of 96 eyes was measured by three different devices; SST (Orbscan II), UP and OCT. Read More

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http://dx.doi.org/10.1186/s12886-020-01411-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278140PMC

Assessment of Eye Disease and Visual Impairment in the Nursing Home Population Using Mobile Health Technology.

Ophthalmic Surg Lasers Imaging Retina 2020 05;51(5):262-270

Background And Objective: To characterize the burden of eye disease and the utility of teleophthalmology in nursing home patients, a population with ophthalmic needs not commensurate with care received.

Patients And Methods: Informed consent was obtained from 78 California Bay Area skilled nursing facility patients. Near visual acuity (VA) and anterior/posterior segment photographs were taken with a smartphone-based VA app and ophthalmic camera system. Read More

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http://dx.doi.org/10.3928/23258160-20200501-03DOI Listing

Albumin excretion rate among patients with diabetic retinopathy.

Caspian J Intern Med 2020 ;11(2):177-182

Department of Biostatistics, Faculty of Public Health, University of Hasanuddin, Makassar, Indonesia.

Background: Chronic microvascular complications consist of diabetic nephropathy (DN), diabetic retinopathy (DR), and diabetic neuropathy. Diabetic nephropathy is assessed through albuminuria, and diabetic retinopathy is assessed through fundoscopy. Several studies have assessed the albuminuria in diabetic retinopathy but have found inconclusive results. Read More

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http://dx.doi.org/10.22088/cjim.11.2.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265519PMC
January 2020

Sirtuin (Sirt) 3 Overexpression Prevents Retinopathy in Streptozotocin-Induced Diabetic Rats.

Med Sci Monit 2020 May 27;26:e920883. Epub 2020 May 27.

Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).

BACKGROUND Sirtuin (Sirt) 3 could promote autophagy by downregulating the expression of genes related to neovascularization in retinal endothelial cells. In this study, we aimed to investigate the effect of Sirt3 overexpression on retinopathy in streptozotocin (STZ)-induced diabetic rats, and to assess its mechanisms. MATERIAL AND METHODS Ntraperitoneal injection of STZ in rats was used to produce a diabetic model. Read More

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http://dx.doi.org/10.12659/MSM.920883DOI Listing

Dysregulation of miR-210 is involved in the development of diabetic retinopathy and serves a regulatory role in retinal vascular endothelial cell proliferation.

Eur J Med Res 2020 May 29;25(1):20. Epub 2020 May 29.

Department of Ophthalmology, Qingdao Chengyang People's Hospital, No. 600, Changcheng Road, Qingdao, Shandong, 266000, China.

Background: Diabetic retinopathy is a common complication of diabetes mellitus (DM). The purpose of this study was to investigate the expression and clinical significance of miR-210 in DR patients and explore the regulatory effect of miR-210 on vascular endothelial cell function under high-glucose condition.

Methods: Quantitative real-time PCR was used to estimate miR-210 expression. Read More

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http://dx.doi.org/10.1186/s40001-020-00416-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271497PMC

What Is the Impact of Intraoperative Microscope-Integrated OCT in Ophthalmic Surgery? Relevant Applications and Outcomes. A Systematic Review.

J Clin Med 2020 Jun 2;9(6). Epub 2020 Jun 2.

Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of the Critical Area, University of Pisa, 56126 Pisa, Italy.

Background: Optical coherence tomography (OCT) has recently been introduced in the operating theatre. The aim of this review is to present the actual role of microscope-integrated optical coherence tomography (MI-OCT) in ophthalmology.

Method: A total of 314 studies were identified, following a literature search adhering to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Read More

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http://dx.doi.org/10.3390/jcm9061682DOI Listing

Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (≥ 30 years) type 2 diabetes without diabetic retinopathy.

Clin Epigenetics 2020 Jun 3;12(1):77. Epub 2020 Jun 3.

Shanghai Eye Diseases Prevention & Treatment Center/Shanghai Eye Hospital, No. 380, Kangding Road, Shanghai, 200040, China.

Background: This study aimed to determine the epigenetic biomarkers of diabetic retinopathy (DR) in subjects with type 2 diabetes mellitus (T2DM). This retrospective study is based on the Shanghai Xinjing community prevention and treatment administrative system of chronic diseases. The subjects enrolled herein were T2DM patients who had undergone long-term follow-up evaluation in the system. Read More

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http://dx.doi.org/10.1186/s13148-020-00871-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268721PMC

The findings of corneal specular microscopy in patients with type-2 diabetes mellitus.

BMC Ophthalmol 2020 Jun 3;20(1):214. Epub 2020 Jun 3.

Erzincan Binali Yildirim University Faculty of Medicine Department of Ophthalmology, 24100, Erzincan, Turkey.

Background: We aimed to compare the morphological characteristics of corneal endothelial cells in type 2 diabetic patients and age-matched healthy subjects by specular microscopy. We also aimed to determine the association of corneal morphological features with the general characteristics and laboratory data of diabetic patients, including disease duration, haemoglobin A1c (HbA1c) levels and urine albumin creatinine ratio.

Methods: A total of 195 diabetic patients and 100 healthy controls were enrolled in the study. Read More

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http://dx.doi.org/10.1186/s12886-020-01488-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271396PMC

Knowledge, attitudes, and practices regarding diabetic retinopathy among primary health care physicians in Al-Hasa, Saudi Arabia.

J Prev Med Hyg 2020 Mar 2;61(1):E85-E91. Epub 2020 Apr 2.

Department of Community Medicine, College of Medicine, King Faisal University, Saudi Arabia.

Background: Diabetic retinopathy (DR) has been shown to be the third most observed cause of visual loss in Saudi Arabia. In the Al-Hasa region in particular, the prevalence of DR has been shown to be 30%. Primary health centre (PHC) physicians play a central role in the early detection and prevention of DR. Read More

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http://dx.doi.org/10.15167/2421-4248/jpmh2020.61.1.1229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225646PMC

Prevalence and Correlates of Cardiovascular Autonomic Neuropathy Among Patients with Diabetes in Uganda: A Hospital-Based Cross-sectional Study.

Glob Heart 2020 Mar 2;15(1):21. Epub 2020 Mar 2.

Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, UG.

Background: Cardiovascular autonomic neuropathy (CAN) is a common complication in individuals with diabetes mellitus (DM) but often overlooked in clinical practice. The burden and correlates of CAN have not been extensively studied in low-income countries, particularly in sub-Saharan Africa.

Objectives: To determine the prevalence and correlates of CAN among adults in ambulatory diabetes care in southwestern Uganda. Read More

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http://dx.doi.org/10.5334/gh.765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218768PMC

Cost Analysis of Teleophthalmology Screening for Diabetic Retinopathy Using Teleophthalmology Billing Codes.

Ophthalmic Surg Lasers Imaging Retina 2020 05;51(5):S26-S34

Background And Objective: To evaluate the financial sustainability of teleophthalmology screening for diabetic retinopathy (DR) using telehealth billing codes.

Patients And Methods: The authors performed an Institutional Review Board-approved retrospective review of medical records, billing data, and quality metrics at the University of California Davis Health System from patients screened for DR through an internal medicine-based telemedicine program using CPT codes 92227 or 92228.

Results: A total of 290 patients received teleophthalmology screening over a 12-month period, resulting in an increase in the DR screening rate from 49% to 63% (P < . Read More

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http://dx.doi.org/10.3928/23258160-20200108-04DOI Listing

Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy.

Diabetol Metab Syndr 2020 19;12:42. Epub 2020 May 19.

1Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000 China.

Background: Neuregulin 4 (Nrg4) is a novel neurotrophic adipokine associated with the development of diabetic peripheral neuropathy (DPN), however, the pathological mechanism remains poorly understood. The purpose of our study was to investigate the association of circulating Nrg4 with DPN and 25-hydroxy vitamin D [25(OH)D], a multifunctional secosteroid hormone that regulates other neurotrophic factors and adipokines gene expression, and other diabetic vascular complications.

Methods: Circulating Nrg4 levels were measured with an ELISA kit in 164 newly diagnosed type 2 diabetes mellitus (nT2DM) patients. Read More

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http://dx.doi.org/10.1186/s13098-020-00550-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236347PMC

PI3Kβ-Regulated Pericyte Maturation Governs Vascular Remodeling.

Circulation 2020 May 29. Epub 2020 May 29.

Vascular Biology and Signalling Group, ProCURE, Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Gran Via de l'Hospitalet 199, 08908 L'Hospitalet de Llobregat, Barcelona, Spain; CIBERONC, Instituto de Salud Carlos III, Av. de Monforte de Lemos, 5, 28029, Madrid, Spain.

Pericytes regulate vessel stabilization and function and their loss is associated with diseases such as diabetic retinopathy or cancer. Despite their physiological importance, pericyte function and molecular regulation during angiogenesis remain poorly understood. To decipher the transcriptomic programs of pericytes during angiogenesis, we crossed the into the RiboTag mice. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.042354DOI Listing

Autoimmune Thyroid Disease is Associated with a Lower Prevalence of Diabetic Retinopathy in Patients with Type 1 Diabetic Mellitus.

Medicina (Kaunas) 2020 May 26;56(6). Epub 2020 May 26.

Clinic of Endocrinology, Diabetology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.

: The aim of the study was to assess the correlation of autoimmune thyroid diseases (AITD) in patients with diabetes mellitus type 1 (DM1) with the occurrence of diabetic retinopathy (DR). : The inclusion criteria for the study were: type 1 diabetes diagnosed on the basis of WHO criteria lasting at least a year, presence of AITD for at least a year, and age over 18 years. The control group consisted of patients without diagnosed AITD (DM1noAITD), selected according to age, BMI and DM1 duration. Read More

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http://dx.doi.org/10.3390/medicina56060255DOI Listing

Hyperspectral Ophthalmoscope Images for the Diagnosis of Diabetic Retinopathy Stage.

J Clin Med 2020 May 26;9(6). Epub 2020 May 26.

Department of Mechanical Engineering and Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, 168, University Rd., Min Hsiung, Chia Yi 62102, Taiwan.

A methodology that applies hyperspectral imaging (HSI) on ophthalmoscope images to identify diabetic retinopathy (DR) stage is demonstrated. First, an algorithm for HSI image analysis is applied to the average reflectance spectra of simulated arteries and veins in ophthalmoscope images. Second, the average simulated spectra are categorized by using a principal component analysis (PCA) score plot. Read More

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http://dx.doi.org/10.3390/jcm9061613DOI Listing