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    A Clinical Decision Support System for Diabetic Retinopathy Screening: Creating a Clinical Support Application.
    Telemed J E Health 2018 Feb 21. Epub 2018 Feb 21.
    2 Department of Computer Engineering and Mathematics, Universitat Rovira & Virgili , Reus, Spain .
    Background: The aim of this study was to build a clinical decision support system (CDSS) in diabetic retinopathy (DR), based on type 2 diabetes mellitus (DM) patients.

    Method: We built a CDSS from a sample of 2,323 patients, divided into a training set of 1,212 patients, and a testing set of 1,111 patients. The CDSS is based on a fuzzy random forest, which is a set of fuzzy decision trees. Read More

    Genetic basis of diabetic kidney disease and other diabetic complications.
    Curr Opin Genet Dev 2018 Feb 13;50:17-24. Epub 2018 Feb 13.
    Folkhälsan Institute of Genetics, Folkhälsan Research Center, 00290 Helsinki, Finland; Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, 00290 Helsinki, Finland; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
    Diabetic kidney disease and other long-term complications are common in diabetes, and comprise the main cause of co-morbidity and premature mortality in individuals with diabetes. While familial clustering and heritability have been reported for all diabetic complications, the genetic background and the molecular mechanisms remain poorly understood. In recent years, genome-wide association studies have identified a few susceptibility loci for the renal complications as well as for diabetic retinopathy, diabetic cardiovascular disease and mortality. Read More

    Diabetic Retinopathy Awareness among Diabetic Patients Attending COMS-TH.
    Kathmandu Univ Med J (KUMJ) 2017 Jan.-Mar.;15(57):79-83
    Department of Ophthalmology, College of Medical Science-Teaching Hospital, Bharatpur, Nepal.
    Background Diabetic retinopathy (DR) is one of the leading causes of blindness in Nepal. Objective The main objective of the study is to know the awareness of diabetic retinopathy among new cases of diabetes mellitus (DM) attending the college of medical science- teaching hospital, Bharatpur, Nepal. Method All the diabetic cases referred for ophthalmic consultation and also referred outpatient department cases from other departments to ophthalmic outpatient department was carried out. Read More

    Gender Difference in the Association of Early- vs. Late-Onset Type 2 Diabetes with Non-Fatal Microvascular Disease in China: A Cross-sectional Study.
    Front Endocrinol (Lausanne) 2018 31;9:15. Epub 2018 Jan 31.
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
    Background: This study aimed to test whether early-onset (defined as <40 years of age) type 2 diabetes mellitus (T2DM) imparted different risks of microvascular disease to Chinese men and women.

    Methods: 222,537 Chinese patients with T2DM were recruited in 630 hospitals from 106 cities in 30 provinces of China in 2012 using a cross-sectional design. Logistic regression analysis was performed to obtain odds ratios (ORs) of male vs. Read More

    Optometry-facilitated teleophthalmology: an audit of the first year in Western Australia.
    Clin Exp Optom 2018 Feb 14. Epub 2018 Feb 14.
    Lions Outback Vision, Lions Eye Institute, Perth, Western Australia, Australia.
    Background: Lions Outback Vision has run a state-wide teleophthalmology service since 2011. In September 2015 the Australian federal government introduced a Medicare reimbursement for optometry-facilitated teleophthalmology consultations under specific circumstances. This audit demonstrates the first 12 months experience with this scheme. Read More

    Higher concentrations of osteoprotegerin in type 1 diabetic patients are related to retinopathy: Results from the Poznań Prospective Study.
    Adv Clin Exp Med 2017 Dec;26(9):1343-1349
    Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland.
    Background: Osteoprotegerin (OPG) is an arterial calcification marker which has been associated with vascular damage. Elevated OPG concentrations associated with low-grade inflammatory processes are found in diabetic subjects.

    Objectives: The aim of the study was to assess concentrations of OPG in relation to the presence of diabetic complications in patients with diabetes type 1 (DM 1) participating in the Poznań Prospective Study (PoProStu). Read More

    A model to study complement involvement in experimental retinal degeneration.
    Ups J Med Sci 2018 Feb 13:1-15. Epub 2018 Feb 13.
    d School of Medical Sciences , Örebro University , Örebro , Sweden.
    Background: The complement system (CS) plays a role in the pathogenesis of a number of ocular diseases, including diabetic retinopathy (DR), glaucoma, uveitis, and age-related macular degeneration (AMD). Given that many of the complex eye-related degenerative diseases have limited treatment opportunities, we aimed to mimic the in vivo retinal degenerative process by developing a relevant co-culture system.

    Method And Materials: The adult porcine retina was co-cultured with the spontaneously arising human retinal pigment epithelial cells-19 (ARPE-19). Read More

    A robust technique based on VLM and Frangi filter for retinal vessel extraction and denoising.
    PLoS One 2018 12;13(2):e0192203. Epub 2018 Feb 12.
    Al-Khawarizmi Institute of Computer Science, UET Lahore, Pakistan.
    The exploration of retinal vessel structure is colossally important on account of numerous diseases including stroke, Diabetic Retinopathy (DR) and coronary heart diseases, which can damage the retinal vessel structure. The retinal vascular network is very hard to be extracted due to its spreading and diminishing geometry and contrast variation in an image. The proposed technique consists of unique parallel processes for denoising and extraction of blood vessels in retinal images. Read More

    Rapidly progressive neovascular glaucoma following coronary artery bypass graft surgery in a patient with type 1 diabetes mellitus: a case report.
    J Med Case Rep 2018 Feb 12;12(1):36. Epub 2018 Feb 12.
    Royal Eye Infirmary, Level 3, Derriford Hospital, Plymouth, PL6 8DH, UK.
    Background: Proliferative diabetic retinopathy leading to vitreous hemorrhage, tractional retinal detachment, and neovascular glaucoma is a major cause of severe sight impairment in adults of working age worldwide. Neovascular glaucoma occurs in 2.5% of patients with proliferative diabetic retinopathy, which is difficult to treat and often leads to blindness. Read More

    Metabolic control and complications in Italian people with diabetes treated with continuous subcutaneous insulin infusion.
    Nutr Metab Cardiovasc Dis 2017 Dec 9. Epub 2017 Dec 9.
    Metabolic Diseases, Department of Medicine-DIMED, University of Padua, Padua, Italy. Electronic address:
    Background And Aim: The objective of this cross-sectional study was to evaluate the degree of glycaemic control and the frequency of diabetic complications in Italian people with diabetes who were treated with continuous subcutaneous insulin infusion (CSII).

    Methods And Results: Questionnaires investigating the organisation of diabetes care centres, individuals' clinical and metabolic features and pump technology and its management were sent to adult and paediatric diabetes centres that use CSII for treatment in Italy. Information on standard clinical variables, demographic data and acute and chronic diabetic complications was derived from local clinical management systems. Read More

    Pre-treatment clinical features in central retinal vein occlusion that predict visual outcome following intravitreal ranibizumab.
    BMC Ophthalmol 2018 Feb 9;18(1):37. Epub 2018 Feb 9.
    Glasgow Centre for Ophthalmic Research, Tennent Institute of Ophthalmology, Gartnavel General Hospital, Greater Glasgow and Clyde, Glasgow, UK.
    Background: Predicting how patients with central retinal vein occlusion (CRVO) will respond to intravitreal anti-VEGF is challenging. The purpose of this study was to identify pre-treatment clinical features in CRVO that predict visual acuity (VA) following intravitreal ranibizumab.

    Methods: Medical records, fundus images and optical coherence tomography (OCT) scans of treatment naïve patients with CRVO receiving PRN intravitreal ranibizumab were retrospectively reviewed. Read More

    Region-specific ischemia, neovascularization and macular edema in treatment-naïve proliferative diabetic retinopathy.
    Clin Exp Ophthalmol 2018 Feb 7. Epub 2018 Feb 7.
    Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, USA.
    Importance: Region-specific pathology in proliferative diabetic retinopathy enhances our understanding and management of this disease.

    Background: To investigate non-perfusion, neovascularization, and macular edema.

    Design: A cross-sectional, observational, non-randomized study. Read More

    Downregulation of MicroRNA 29a/b exacerbated diabetic retinopathy by impairing the function of Müller cells via Forkhead box protein O4.
    Diab Vasc Dis Res 2018 Feb 1:1479164118756239. Epub 2018 Feb 1.
    Department of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.
    Background: Diabetic retinopathy is a neurological disease, which can lead to blindness in severe cases. The pathogenesis underlying diabetic retinopathy is unclear. The aim of this study was to explore the role of dysregulated microRNA 29a/b in the onset and progression of diabetic retinopathy. Read More

    Α-Melanocyte-Stimulating Hormone Protects Early Diabetic Retina from Blood-Retinal Barrier Breakdown and Vascular Leakage via MC4R.
    Cell Physiol Biochem 2018 25;45(2):505-522. Epub 2018 Jan 25.
    Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, College of Optometry and Ophthalmology, Tianjin Medical University, Tianjin, China.
    Background/aims: Blood-retinal barrier (BRB) breakdown and vascular leakage is the leading cause of blindness of diabetic retinopathy (DR). Hyperglycemia-induced oxidative stress and inflammation are primary pathogenic factors of this severe DR complication. An effective interventional modality against the pathogenic factors during early DR is needed to curb BRB breakdown and vascular leakage. Read More

    Long non-coding RNA nuclear paraspeckle assembly transcript 1 inhibits the apoptosis of retina Müller cells after diabetic retinopathy through regulating miR-497/brain-derived neurotrophic factor axis.
    Diab Vasc Dis Res 2018 Jan 1:1479164117749382. Epub 2018 Jan 1.
    Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    Background: The role of long non-coding RNA in diabetic retinopathy, a serious complication of diabetes mellitus, has attracted increasing attention in recent years. The purpose of this study was to explore whether long non-coding RNA nuclear paraspeckle assembly transcript 1 was involved in the context of diabetic retinopathy and its underlying mechanisms.

    Results: Our results revealed that nuclear paraspeckle assembly transcript 1 was significantly downregulated in the retina of diabetes mellitus rats. Read More

    The economic impact of sight loss and blindness in the UK adult population.
    BMC Health Serv Res 2018 01 30;18(1):63. Epub 2018 Jan 30.
    Leeds Institute of Health Sciences, University of Leeds, London, UK.
    Background: To quantify the economic impact of sight loss and blindness in the United Kingdom (UK) population, including direct and indirect costs, and its burden on health.

    Methods: Prevalence data on sight loss and blindness by condition, Census demographic data, data on indirect costs, and healthcare cost databases were used. Blindness was defined as best corrected visual acuity (BCVA) of < 6/60, and sight loss as BCVA < 6/12 to 6/60, in the better-seeing eye. Read More

    The Beijing Desheng Diabetic Eye Study: rationale, design, methodology and baseline data.
    Int J Ophthalmol 2018 18;11(1):108-116. Epub 2018 Jan 18.
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China.
    Aim: To present the rationale, design, methodology, and the baseline data of the Beijing Desheng Diabetic Eye Study (BDDES), and to determine the prevalence of diabetic retinopathy (DR) and possible risk factors in patients with type 2 diabetes mellitus (T2DM) in an urban community of Beijing, China.

    Methods: Community-based prospective cohort study of persons diagnosed with T2DM aged 30y or older. The main variables of interest are the presence and progression of DR as determined by the standardized ETDRS grading of seven fields fundus photographs. Read More

    Prevalence of Chronic Diabetic Complications in Newly Diagnosed versus Known Type 2 Diabetic Subjects in a Sample of Alexandria Population, Egypt.
    Curr Diabetes Rev 2018 Jan 24. Epub 2018 Jan 24.
    Department of Ophthalmology, Faculty of Medicine, Alexandria University. Egypt.
    Background: In Egypt, data on the prevalence of chronic diabetic complications, which are essential for the adjustment of policies and practices related to diabetes care, are scarce. Therefore, the aim of this study was to determine the frequency of chronic complications of diabetes; namely neuropathy, diabetic kidney disease (DKD), retinopathy and peripheral arterial disease (PAD) in newly-diagnosed versus known type 2 diabetic patients.

    Subjects & Methods: This is a cross-sectional study that is based on a previous household survey conducted on a representative sample of the population of Alexandria, Egypt. Read More

    Automated diabetic retinopathy detection using optical coherence tomography angiography: a pilot study.
    Br J Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Bioengineering Department, University of Louisville, Louisville, Kentucky, USA.
    Background: Optical coherence tomography angiography (OCTA) is increasingly being used to evaluate diabetic retinopathy, but the interpretation of OCTA remains largely subjective. The purpose of this study was to design a computer-aided diagnostic (CAD) system to diagnose non-proliferative diabetic retinopathy (NPDR) in an automated fashion using OCTA images.

    Methods: This was a two-centre, cross-sectional study. Read More

    Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Eye & Vision Health, College of Medicine & Public Health, Flinders University, Adelaide, Australia.
    Background: Over-production of reactive oxygen species (ROS) and resulting oxidative stress contribute to retinal damage in vascular diseases that include diabetic retinopathy, retinopathy of prematurity and major retinal vessel occlusions. NADPH oxidase (Nox) proteins are professional ROS-generating enzymes, and therapeutic targeting in these diseases has strong appeal. Pharmacological inhibition of Nox4 reduces the severity of experimental retinal vasculopathy. Read More

    Diet soft drink is associated with increased odds of proliferative diabetic retinopathy.
    Clin Exp Ophthalmol 2018 Jan 23. Epub 2018 Jan 23.
    Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Australia.
    Importance: While consumption of soft drink may increase risk of cardiovascular disease, the relationship between soft drink consumption and diabetes complications is unknown.

    Background: To explore the association between regular and diet soft drink consumption, and diabetic retinopathy (DR) and diabetic macular edema (DME).

    Design: Clinical, cross-sectional study PARTICIPANTS: Adult patients with diabetes recruited from a tertiary eye hospital (Melbourne, Australia) answered a Food Frequency Questionnaire. Read More

    Diabetic retinopathy and the use of laser photocoagulation: is it cost-effective to treat early?
    BMJ Open Ophthalmol 2017 25;2(1):e000021. Epub 2017 Sep 25.
    Warwick Medical School, University of Warwick, Coventry, UK.
    Background/aims: The aim of the study was to explore whether it would be cost-effective to apply panretinal photocoagulation (PRP) at the severe non-proliferative diabetic retinopathy (NPDR) (early treatment) stage, compared with waiting until high-risk proliferative diabetic retinopathy (HR-PDR) characteristics (deferred treatment) developed.

    Methods: A Markov model with a 30-year time horizon was developed, in which patients presenting with moderate NPDR could progress through all stages of DR (severe NPDR>early PDR>HR-PDR>severe PDR) to severe vision loss and blindness (and to death). A National Health Service and personal social services perspective was adopted. Read More

    Diabetic retinopathy screening and treatment in Myanmar: a pilot study.
    BMJ Open Ophthalmol 2017 9;1(1):e000084. Epub 2017 Jun 9.
    Department of Ophthalmology, Sitagu international Missionary Association, Sagaing Hills, Sagaing, Myanmar.
    Background/aims: The goals of this pilot study were (a) to demonstrate the feasibility of identifying patients with vision-threatening diabetic retinopathy (DR) in a provincial area of Myanmar and treating them with portable lasers and (b) to gather data specific to Myanmar to help design larger cross-sectional studies of DR prevalence in Myanmar.

    Methods: 97 consecutive patients with diabetes mellitus (DM) were identified by local ophthalmologists over a period of 1 month in Pyinmana, Myanmar and were referred to the pilot screening programme. Patients' demographics were recorded and their eyes were examined. Read More

    Bilateral Hypopyon Uveitis in Chronic Myeloid Leukemia.
    Ocul Oncol Pathol 2017 Dec 3;4(1):12-15. Epub 2017 Jun 3.
    Army College of Medical Sciences, New Delhi, India.
    Background: A leukemic hypopyon is considered an early sign of central nervous system involvement or systemic relapse. A differential diagnosis of masquerade syndromes should be considered in cases of hypopyon uveitis that are atypical or unresponsive to treatment. We report a case of a 45-year-old man who presented with bilateral hypopyon uveitis and was subsequently diagnosed as having chronic myeloid leukemia. Read More

    Effect of intravitreal triamcinolone acetonide injection at the end of vitrectomy for vitreous haemorrhage related to proliferative diabetic retinopathy.
    Br J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida, Fukui, Japan.
    Background/aims: To investigate whether intravitreal injection of triamcinolone acetonide (IVTA) combined with vitrectomy prevents postoperative inflammation in patients with vitreous haemorrhage (VH) due to proliferative diabetic retinopathy (PDR).

    Methods: This prospective, multicentre, randomised study conducted at seven sites in Japan enrolled patients diagnosed as having VH following PDR. Patients underwent vitrectomy with (IVTA+VIT group) or without (VIT group) IVTA at the end of the surgery. Read More

    Interventions to increase attendance for diabetic retinopathy screening.
    Cochrane Database Syst Rev 2018 01 15;1:CD012054. Epub 2018 Jan 15.
    Centre for Applied Vision Research, School of Health Sciences, City University of London, Northampton Square, London, UK, EC1V 0HB.
    Background: Despite evidence supporting the effectiveness of diabetic retinopathy screening (DRS) in reducing the risk of sight loss, attendance for screening is consistently below recommended levels.

    Objectives: The primary objective of the review was to assess the effectiveness of quality improvement (QI) interventions that seek to increase attendance for DRS in people with type 1 and type 2 diabetes.Secondary objectives were:To use validated taxonomies of QI intervention strategies and behaviour change techniques (BCTs) to code the description of interventions in the included studies and determine whether interventions that include particular QI strategies or component BCTs are more effective in increasing screening attendance;To explore heterogeneity in effect size within and between studies to identify potential explanatory factors for variability in effect size;To explore differential effects in subgroups to provide information on how equity of screening attendance could be improved;To critically appraise and summarise current evidence on the resource use, costs and cost effectiveness. Read More

    Relationship between cardiac microvascular dysfunction measured with 82Rubidium-PET and albuminuria in patients with diabetes mellitus.
    Cardiovasc Diabetol 2018 Jan 11;17(1):11. Epub 2018 Jan 11.
    Paris Diderot-Sorbonne Paris Cité University, Paris, France.
    Background: Albuminuria is of one the strongest predictors of cardiovascular disease (CVD) in diabetes. Diabetes is associated with cardiac microvascular dysfunction (CMD), a powerful, independent prognostic factor for cardiac mortality. The aim of this study was to evaluate the relationship between CMD and microvascular complications in patients without known CVD. Read More

    Implementation of medical retina virtual clinics in a tertiary eye care referral centre.
    Br J Ophthalmol 2018 Jan 6. Epub 2018 Jan 6.
    Medical Retina Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
    Background: The increasing incidence of medical retinal diseases has created capacity issues across UK. In this study, we describe the implementation and outcomes of virtual medical retina clinics (VMRCs) at Moorfields Eye Hospital, South Division, London. It represents a promising solution to ensure that patients are seen and treated in a timely fashion METHODS: First attendances in the VMRC (September 2016-May 2017) were included. Read More

    Small-Gauge Endoscopy-Guided Pneumatic Anterior Hyaloid Detachment: A New Surgical Technique for Combined Pars Plana Vitrectomy and Pars Plana Glaucoma Drainage Implant.
    Ophthalmic Surg Lasers Imaging Retina 2018 Jan;49(1):48-50
    Background And Objective: Pars plana glaucoma drainage implant (GDI) occlusion is mainly related to entrapment of residual anterior vitreous gel in the implant. The aim of the present report is to describe a new surgical technique to induce pneumatic anterior hyaloid detachment in eyes with GDI.

    Patients And Methods: This is a description of the surgical technique used to induce pneumatic anterior hyaloid detachment. Read More

    Propranolol for Proliferative Diabetic Retinopathy.
    Ophthalmic Surg Lasers Imaging Retina 2018 01;49(1):35-40
    Background And Objective: To determine the effect of propranolol on retinal neovascularization due to proliferative diabetic retinopathy (PDR).

    Patients And Methods: For this prospective pilot, interventional, case series, patients with diabetes with PDR (n = 10 subjects; 12 eyes) were recruited at the ophthalmology clinic of the University of Wisconsin - Madison. Subjects were administered oral propranolol for 12 weeks and retinopathy and area of retinal neovascularization were monitored with fundus photography and fluorescein angiography (FA). Read More

    Prevalence and determinants of diabetes distress in patients of diabetes mellitus in a tertiary care centre.
    Diabetes Metab Syndr 2017 Dec 22. Epub 2017 Dec 22.
    Department of Psychiatry, Pt. B.D.S. PGIMS, Rohtak, Haryana, India.
    Background: Patients of diabetes mellitus experience psychological difficulties associated with their disease which remains unrecognized involving several states related to coping with diabetes. Diabetes distress is a distinct condition which is often mistaken for depression and is related to adverse disease outcomes.

    Aims And Objective: To study the prevalence and predictors of diabetes distress in patients of Type 2 Diabetes mellitus (T2DM) in a tertiary care centre. Read More

    Idiopathic macular telangiectasis type 2 and co-existent diabetic retinopathy.
    Int J Retina Vitreous 2017 25;3:50. Epub 2017 Dec 25.
    Srimati Kanuri Santhamma Retina Vitreous Center, L.V. Prasad Eye Institute, Kallam Anji Reddy Campus, L V Prasad Marg, Banjara Hills, Hyderabad, Telangana 500 034 India.
    Background: To study the interaction between idiopathic macular telangiectasis type 2 (MacTel2) and coexistent diabetic retinopathy (DR) during long term follow up.

    Methods: A retrospective chart review was done for all eyes with MacTel2 and DR with a minimum 2 years follow up. Eyes with other retinal disorders and poor quality imaging were excluded. Read More

    Predictors of uptake of eye examination in people living with diabetes mellitus in three counties of Kenya.
    Trop Med Health 2017 21;45:41. Epub 2017 Dec 21.
    London School of Hygiene and Tropical Medicine, London, UK.
    Background: Diabetic retinopathy (DR) is a significant public health concern that is potentially blinding. Clinical practice guidelines recommend annual eye examination of patients with diabetes for early detection of DR. Our aim was to identify the demand-side factors that influence uptake of eye examination among patients already utilizing diabetes services in three counties of Kenya. Read More

    Expression, distribution and function of kinin Breceptor in the rat diabetic retina.
    Br J Pharmacol 2017 Dec 29. Epub 2017 Dec 29.
    École d'optométrie, Université de Montréal, Montréal, QC, Canada.
    Background And Purpose: The kinin Breceptor contributes to vascular inflammation and blood-retinal barrier breakdown in diabetic retinopathy (DR). We investigated the changes in expression, cellular localization and vascular inflammatory effect of Breceptors in retina of streptozotocin diabetic rats.

    Experimental Approach: The distribution of Breceptors on retinal cell types was investigated by immunocytochemistry. Read More

    Neutrophil-lymphocyte Ratio is a Novel Reliable Predictor of Nephropathy, Retinopathy, and Coronary Artery Disease in Indians with Type-2 Diabetes.
    Indian J Endocrinol Metab 2017 Nov-Dec;21(6):864-870
    Department of Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
    Background And Aims: Neutrophil-lymphocyte ratio (NLR) has been suggested to be a predictor of coronary artery disease (CAD), and end-organ damage in type-2 diabetes mellitus (T2DM). Similar data are lacking from Indians with T2DM. Hence, this study aimed to evaluate the role of NLR as a predictor of microvascular complications and CAD in T2DM. Read More

    Assessment of visual morbidity amongst diabetic retinopathy at tertiary eye care center, Nepal: a cross-sectional descriptive study.
    BMC Ophthalmol 2017 Dec 28;17(1):263. Epub 2017 Dec 28.
    Universal College of Medical Sciences, Bhairahawa, Nepal.
    Background: Diabetic retinopathy (DR) is one of the leading causes of preventable blindness in low and middle income countries. In Nepal, there are less studies regarding DR and they too are limited around Kathmandu valley. This study was done to assess visual morbidity in patients with DR at a peripheral tertiary eye care center of Nepal. Read More

    Prevalence of thyroid disorders in North Indian Type 2 diabetic subjects: A cross sectional study.
    Diabetes Metab Syndr 2017 Dec 20. Epub 2017 Dec 20.
    Rajiv Gandhi Centre for Diabetes and Endocrinology, Faculty of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, India. Electronic address:
    Background: Type 2 diabetes mellitus (T2DM) is a major health burden worldwide with many patients encountering thyroid dysfunction later in their life. Various studies have found that diabetes and thyroid disorders mutually influence each other and both disorders tend to coexists. However, the prevalence of thyroid dysfunction and associated clinical variables in these patients has not been investigated. Read More

    Protective Effects of Leukemia Inhibitory Factor on Retinal Vasculature and Cells in Streptozotocin-induced Diabetic Mice.
    Chin Med J (Engl) 2018 Jan;131(1):75-81
    Department of Ophthalmology, The Friendship Hospital, Capital Medical University, Beijing 100050, China.
    Background: Leukemia inhibitory factor (LIF) has been reported to possess various pharmacological effects, including displaying vascular and neuroprotective properties, during retinal disease. The aim of this study was to investigate the vascular and structural changes in the retina of diabetic mice and to explore whether LIF prevents experimental diabetes-induced retinal injury in the early stages.

    Methods: Diabetes was induced in C57Bl/6J mice with streptozotocin (STZ) injections. Read More

    Retinal malperfusion in albuminuric Type 1 diabetes mellitus patients without clinical signs of diabetic retinopathy: a prospective pilot study.
    Int J Retina Vitreous 2017 18;3:49. Epub 2017 Dec 18.
    Department of Endocrinology, Federal University of São Paulo, São Paulo, Brazil.
    Background: To report fluorescein angiography findings in a group of albuminuric Type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy.

    Methods: Fifteen albuminuric T1DM patients with normal/near normal estimated glomerular filtration rate without diabetic retinopathy underwent fluorescein angiography; presence of microaneurysms, vascular permeability changes and retinal malperfusion were evaluated.

    Results: Fluorescein angiography revealed microaneurysms, blood-retinal barrier breakdown and retinal ischemia in 10 (67%) and 11 (73%); 8 (53%) and 9 (60%); 2 (13%) and 5 (33%) of patients at baseline and follow up, respectively. Read More

    Quantitative assessment of angiogenesis and pericyte coverage in human cell-derived vascular sprouts.
    Inflamm Regen 2017 18;37. Epub 2017 Jan 18.
    Institute of Metabolic Physiology, Heinrich-Heine University, Düsseldorf, Germany.
    Background: Pericytes, surrounding the endothelium, fulfill diverse functions that are crucial for vascular homeostasis. The loss of pericytes is associated with pathologies, such as diabetic retinopathy and Alzheimer's disease. Thus, there exists a need for an experimental system that combines pharmacologic manipulation and quantification of pericyte coverage during sprouting angiogenesis. Read More

    A case of proliferative diabetic retinopathy in which scintillating particles appeared in the intravitreal cavity after laser photocoagulation.
    BMC Ophthalmol 2017 Dec 19;17(1):254. Epub 2017 Dec 19.
    Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.
    Background: To report a case of proliferative diabetic retinopathy (PDR) exhibiting the appearance of scintillating particles presumed to be crystallin inside the intravitreal cavity after laser photocoagulation.

    Case Presentation: A 56-year-old male patient presented at our outpatient clinic after becoming aware of decreased vision in his right eye. Ocular examination performed at the patient's initial visit revealed a massive preretinal macular hemorrhage due to PDR in his right eye. Read More

    Choroidal Thickness Change in Patients With Diabetic Macular Edema.
    Ophthalmic Surg Lasers Imaging Retina 2017 Dec;48(12):970-977
    Background And Objective: To evaluate subfoveal choroidal thickness (SFCT) in diabetic macular edema (DME) and its relationships.

    Patients And Methods: One hundred and six eyes were included in this prospective, nonrandomized case control study. They were divided into 37 cases of healthy, normal subjects and 69 cases of nonproliferative diabetic retinopathy (NPDR) with DME. Read More

    Predictions of ocular changes caused by diabetes in glaucoma patients.
    Comput Methods Programs Biomed 2018 Feb 15;154:183-190. Epub 2017 Nov 15.
    University of Medicine and Farmacy "Gr. T. Popa" Iasi, Surgery Department, Romania; Ophthalmology Clinic, University Street No 16, Iasi 700115, Romania.
    Background And Objective: This paper builds different neural network models with simple topologies, having one or two hidden layers which were subsequently employed in the prediction of ocular changes progression in patients with diabetes associated with primer open-angle glaucoma.

    Material And Methods: For attempting to indicate whether there is a relationship between glaucoma and diabetes, a simulation method, based on artificial neural networks (ANN), Jordan Elman networks (JEN) type, in particular, was applied in conjunction with clinical observation. The study was conducted on a sample of 101 eyes with open angle glaucoma included and, in each case, the patients had associated diabetes mellitus. Read More

    The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes.
    Biochim Biophys Acta 2018 Mar 13;1864(3):758-763. Epub 2017 Dec 13.
    Chair & Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.
    Background And Aims: KLOTHO is an anti-ageing circulating hormone involved in insulin signaling, inflammation and vascular homeostasis through its protective effects on the endothelium and antioxidant actions. The common functional "KL-VS" variant of the KLOTHO gene is reproducibly associated with longevity in humans. Large number of studies have evaluated close relationship between KLOTHO protein and diabetes but the association between KL-VS variant and retinopathy in type 1 diabetes mellitus (T1D) is unknown. Read More

    Antivascular endothelial growth factor agents pretreatment before vitrectomy for complicated proliferative diabetic retinopathy: a meta-analysis of randomised controlled trials.
    Br J Ophthalmol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    Background/aims: To evaluate the efficacy of antivascular endothelial growth factor (anti-VEGF) agents pretreatment before vitrectomy for patients with complicated proliferative diabetic retinopathy (PDR).

    Methods: The PubMed, Embase and the Cochrane Central Register of Controlled Trials were searched up to June 2017 to identify related studies. The Peferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed. Read More

    Dexamethasone implants in paediatric patients with noninfectious intermediate or posterior uveitis: first prospective exploratory case series.
    BMC Ophthalmol 2017 Dec 16;17(1):252. Epub 2017 Dec 16.
    Department of Ophthalmology, Campus Virchow- Klinikum, Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt- Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
    Background: To evaluate the efficacy and safety of dexamethasone (DEX) implants in paediatric patients with noninfectious intermediate or posterior uveitis.

    Methods: Prospective single center exploratory case series. Children and adolescents, 6 to 17 years old, with a vitreous haze score of ≥1. Read More

    Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus.
    Med Sci Monit 2017 Dec 14;23:5916-5923. Epub 2017 Dec 14.
    Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
    BACKGROUND Several studies demonstrated that bilirubin, a potent endogenous antioxidant, is a strong protective factor for many diabetic complications such as nephropathy, retinopathy, neuropathy, and vasculopathy. The purpose of this study was to assess the association between serum bilirubin levels and diabetic foot (DF) in Chinese patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS The present cross-sectional study of bilirubin levels in relation to DF was conducted in 1,269 T2DM patients with (n=578) and without (n=691) DF. Read More

    Association of -1082A>G Polymorphism in the Interleukin-10 Gene with Estimated Glomerular Filtration Rate in Type 2 Diabetes.
    Kidney Blood Press Res 2017 8;42(6):1164-1174. Epub 2017 Dec 8.
    Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil.
    Background/aims: The -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene has been associated with type 2 diabetes and diabetic retinopathy, but its relationship with diabetic kidney disease (DKD) is uncertain. The aim of this case-control study was to investigate whether the -1082A>G polymorphism is associated with DKD in white Brazilians with type 2 diabetes mellitus.

    Methods: Genotyping was done by real-time polymerase chain reaction for 597 type 2 diabetic outpatients. Read More

    Five-year visual outcome among people with correctable visual impairment: the Liwan Eye Study.
    Clin Exp Ophthalmol 2017 Dec 7. Epub 2017 Dec 7.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
    Importance: Longitudinal data on visual outcome of correctable visual impairments (VI) are of paramount importance for decision-maker to estimate burden and demand to treat avoidable VI.

    Background: To assess the 5-year visual outcome among participants with correctable VI and to identify associated risk factors.

    Design: Population-based longitudinal cohort study. Read More

    miRNA-1273g-3p Involvement in Development of Diabetic Retinopathy by Modulating the Autophagy-Lysosome Pathway.
    Med Sci Monit 2017 Dec 3;23:5744-5751. Epub 2017 Dec 3.
    Department of Ophthalmology, The PLA General Hospital, Beijing, China (mainland).
    BACKGROUND Diabetic retinopathy (DR) is one of the most common and serious complications of diabetes mellitus (DM). The autophagy-lysosome pathway (ALP) is one of the main intracellular self-digestive degradation systems. Lysosomal impairment and autophagic dysfunction are early events in the pathogenesis of DR, suggesting autophagy might be a novel therapeutic strategy for DR treatment. Read More

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