1,129 results match your criteria Retinoblastoma Imaging

Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma.

Acta Pharm Sin B 2022 Jun 22;12(6):2731-2739. Epub 2021 Oct 22.

Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.

Photothermal therapy has the characteristics of minimal invasiveness, controllability, high efficiency, and strong specificity, which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. However, due to the limited tissue penetration of infrared light, it is difficult to promote and apply in clinical practice. The eye is the only transparent tissue in human, and infrared light can easily penetrate the eye tissue, so it is expected that photothermal therapy can be used to treat fundus diseases. Read More

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MRI can reliably differentiate optic nerve inflammation from tumor invasion in retinoblastoma with orbital cellulitis.

Ophthalmology 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands; European Retinoblastoma Imaging Collaboration (ERIC).

Objective: To investigate prevalence and MRI phenotype of retinoblastoma-associated orbital cellulitis. Additionally, this study aimed to identify postlaminar optic nerve enhancement patterns differentiating between inflammation and tumor invasion.

Design: A monocenter cohort study assessed the prevalence of orbital cellulitis features on MRI in retinoblastoma patients. Read More

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An atypical clinical/radiological presentation of Retinoblastoma in a 4-year-old child: A case report & educational lessons from Syria.

Ann Med Surg (Lond) 2022 Jun 18;78:103830. Epub 2022 May 18.

Department of Pathology, Cancer Research Center, Tishreen University Hospital, Latakia, Syria.

Introduction: Retinoblastoma (Rb), the most common intraocular malignancy of children, typically presents with leukocoria or strabismus, and in later stages, the most common sign may be proptosis. Radiological techniques show calcification as an important finding for the diagnoses. This neoplasm can mimic any orbital or ocular disease in its atypical clinical/radiological presentations, which delay the diagnosis leading to high mortality rates. Read More

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Recent advances in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms.

World J Gastrointest Surg 2022 May;14(5):383-396

Clinic of General Surgery, Molecular Oncology and Immunotherapy, Rostock University Medical Center, 18057 Rostock, Germany.

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a rare group of tumors originating from neuroendocrine cells of the digestive system. Their incidence has increased over the last decades. The specific pathogenetic mechanisms underlying GEP-NEN development have not been completely revealed. Read More

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Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022.

Eur J Cancer 2022 Jun 19;171:203-231. Epub 2022 Jun 19.

Universite' de Paris, INSERM U976, AP-HP, Dermatology Department, Saint Louis Hospital, Paris, France. Electronic address:

Merkel cell carcinoma (MCC) is a rare skin cancer, accounting for less than 1% of all cutaneous malignancies. It is found predominantly in white populations and risk factors include advanced age, ultraviolet exposure, male sex, immunosuppression, such as AIDS/HIV infection, haematological malignancies or solid organ transplantation, and Merkel cell polyomavirus infection. MCC is an aggressive tumour with 26% of cases presenting lymph node involvement at diagnosis and 8% with distant metastases. Read More

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Pediatric Oculo-orbital Tumor Characteristics, Imaging and Histopathology Agreement in a Tertiary Level Teaching Hospital, Ethiopia.

Ethiop J Health Sci 2022 Mar;32(2):313-320

Department of Radiology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Oculo-orbital tumors are frequently encountered pathologies and late diagnosis results in high morbidity and mortality in developing countries. This study aims to assess the computed tomography and magnetic resonance imaging patterns of pediatric oculo-orbital tumors with particular emphasis on retinoblastoma and compare agreement between imaging and histopathology diagnosis.

Methods: A retrospective analysis of 101 pediatric patients with oculo-orbital lesions from February 2017 to January 2020 at Tikur Anbessa Specialized Hospital oncology center. Read More

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Tumor specifically internalizing peptide 'HN-1': Targeting the putative receptor retinoblastoma-regulated discoidin domain receptor 1 involved in metastasis.

World J Clin Oncol 2022 May;13(5):323-338

Research & Development, Bio-Synthesis, Inc., Lewisville, TX 75057, United States.

Background: Less than 0.5% of intravenously injected drugs reach tumors, contributing to side effects. To limit damage to healthy cells, various delivery vectors have been formulated; yet, previously developed vectors suffer from poor penetration into solid tumors. Read More

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Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles.

Drug Deliv 2022 Dec;29(1):1785-1799

Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.

Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are expected to realize the integration of early diagnosis and early treatment. Read More

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December 2022

[Near-infrared Fundus Autofluorescence: Clinical Application and Diagnostic Relevance].

Klin Monbl Augenheilkd 2022 May 24. Epub 2022 May 24.

Near-infrared autofluorescence (NIA) is a non-invasive retinal imaging technique for examination of the retinal pigment epithelium (RPE) based on the autofluorescence of melanin. Melanin has several functions within the RPE cells, in one of them it serves as a protective antioxidative factor within the RPE cells and is involved in the phagocytosis of photoreceptor outer segments. Disorders that affect the photoreceptor-RPE complex result in alterations of RPE cells which are detectable by alterations of NIA. Read More

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Liquid biopsy in Retinoblastoma: A review.

Semin Ophthalmol 2022 May 23:1-7. Epub 2022 May 23.

Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India.

Purpose: Retinoblastoma (RB) is the most common intraocular malignancy in children. The diagnosis of RB is mainly based on clinical features and imaging characteristics. Prognosis is based on stage of disease and response to treatment. Read More

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Ultrawide-field OCT for Retinoblastoma.

Ophthalmology 2022 06;129(6):718

Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon.

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Dual ophthalmic arteries: a new case.

Surg Radiol Anat 2022 May 22;44(5):721-725. Epub 2022 May 22.

Faculty of Medicine, Department of Radiology, Hacettepe University, 06100, Ankara, Turkey.

We report one retinoblastoma patient with dual ophthalmic arteries (also known as "double ophthalmic arteries") arising from the internal carotid artery which fuse with each other inside the orbit. The caudal ophthalmic artery with larger caliber originated from the cavernous segment of internal carotid artery and passed through the superior orbital fissure. The cranial and tiny one arose more cranially from the supraclinoid internal carotid artery and passed through the optic canal. Read More

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Single-cell imaging of the cell cycle reveals CDC25B-induced heterogeneity of G1 phase length in neural progenitor cells.

Development 2022 Jun 10;149(11). Epub 2022 Jun 10.

Unité de Biologie Moléculaire, Cellulaire et du Développement (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, Université Toulouse III - Paul Sabatier, Toulouse 31062 CEDEX 9, France.

Although lengthening of the cell cycle and G1 phase is a generic feature of tissue maturation during development, the underlying mechanism remains poorly understood. Here, we develop a time-lapse imaging strategy to measure the four cell cycle phases in single chick neural progenitor cells in their endogenous environment. We show that neural progenitors are widely heterogeneous with respect to cell cycle length. Read More

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-Negative Retinal Organoids Display Proliferation of Cone Photoreceptors and Loss of Retinal Differentiation.

Cancers (Basel) 2022 Apr 26;14(9). Epub 2022 Apr 26.

Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

Retinoblastoma is a tumor of the eye in children under the age of five caused by biallelic inactivation of the tumor suppressor gene in maturing retinal cells. Cancer models are essential for understanding tumor development and in preclinical research. Because of the complex organization of the human retina, such models were challenging to develop for retinoblastoma. Read More

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Presumed avulsed iris collarette.

S Lemaître G Hay

J Fr Ophtalmol 2022 06 4;45(6):682-683. Epub 2022 May 4.

Ocular Oncology Service, Moorfields Eye Hospital, 162, City Road, London EC1V 2PD, United Kingdom; University College London, Institute of Ophthalmology, 11-43, Bath Street, London EC1V 9EL, United Kingdom.

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Anterior chamber enhancement predicts optic nerve infiltration in retinoblastoma.

Eur Radiol 2022 May 7. Epub 2022 May 7.

Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.

Objectives: As described recently, intravenously injected gadolinium-based contrast agent (GBCA) penetrates into the anterior eye chamber (AC) and is drained from the retina to the distal optic nerve (ON) along perivascular spaces, which serves retinal homeostasis and was termed the orbital glymphatic system (GS). Independently, AC enhancement predicted ON infiltration, a major risk factor for advanced retinoblastoma (RB), in a small RB patient cohort. We aimed to review the supposed imaging biomarker for ON infiltration in a large RB cohort and with respect to the recently described orbital GS. Read More

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Clinical Characteristics and Image Manifestations of a Rare Retinoblastoma with a Bone Metastasis.

Cancer Manag Res 2022 26;14:1565-1575. Epub 2022 Apr 26.

Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.

Purpose: Retinoblastoma (RB) is the most common intraocular malignancy in infancy and childhood. This study evaluated the clinical and imaging features, treatment, and prognosis of patients with recurrent RB with limb bone metastases and without central nervous system involvement.

Patients And Methods: The clinical data of five patients with RB with limb bone metastases who were diagnosed at the Department of Pediatrics in Beijing Tongren Hospital between January 2015 and January 2021 were analyzed retrospectively. Read More

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A short-term chick embryo xenograft model to study retinoblastoma cancer stem cells.

Indian J Ophthalmol 2022 05;70(5):1703-1711

School of Medical Sciences, University of Hyderabad, Hyderabad, India.

Purpose: Cancer stem cells (CSCs) reported in various tumors play a crucial role in tumorigenesis and metastasis of retinoblastoma (Rb). Following the efforts to reduce, replace, and refine the use of mammalian models, we aimed to establish a short-term xenograft for Rb to evaluate the CSC properties of CD133 Rb Y79 cells, using the well-established chick embryo chorioallantoic membrane (CE-CAM) assay.

Methods: Y79 cells were cultured, labeled with two different dyes (CM-Dil Y79 and enhanced green fluorescent protein (eGFP)) and sorted for CD133 and CD133 + subsets. Read More

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Wide-field Fundus Imaging and Fluorescein Angiography Findings in Various Pseudoretinoblastoma Conditions.

J Pediatr Ophthalmol Strabismus 2022 Apr 21:1-15. Epub 2022 Apr 21.

Purpose: To report wide-field fundus imaging and fluorescein angiography findings in conditions mimicking retinoblastoma (pseudoretinoblastoma).

Methods: The clinical and imaging records of 28 patients (36 eyes) imaged with RetCam 3 (Clarity Medical Systems, Inc) wide-field fundus photography and fluorescein angiography who were diagnosed as having various pseudoretinoblastoma disorders between February 2020 and August 2021 were retrospectively evaluated.

Results: Most patients were referred with suspicion of retinoblastoma. Read More

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Multimodal imaging of a unilateral large retinoma.

J Fr Ophtalmol 2022 05 14;45(5):e227-e230. Epub 2022 Apr 14.

Service d'ophtalmologie, CHU de Saint-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France; Biologie, ingénierie et imagerie de la greffe de Cornée (BiiGC), campus santé innovations, 10, rue de Marandière, 42270 Saint-Priest-en-Jarez, France. Electronic address:

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Novel RB1 germline mutation in a healthy man.

Ophthalmic Genet 2022 Apr 11:1-6. Epub 2022 Apr 11.

Ocular Oncology Service, Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico.

Background: Retinoblastoma (Rb) most frequently presents as a unilateral sporadic disease up to 40% of cases, however, arise from a monoallelic germline pathogenic variant. Only 10% of the germline mutations are inherited, and high penetrance is seen in up to 90% of these cases. As an effort to optimize counseling and screening, mutations are classified according to inheritance patterns. Read More

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The Effect of Microbubble-Assisted Ultrasound on Molecular Permeability across Cell Barriers.

Pharmaceutics 2022 Feb 24;14(3). Epub 2022 Feb 24.

Imaging and Oncology Division, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

The combination of ultrasound and microbubbles (USMB) has been applied to enhance drug permeability across tissue barriers. Most studies focused on only one physicochemical aspect (i.e. Read More

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February 2022

Characterization of the Portuguese population diagnosed with retinoblastoma.

Sci Rep 2022 03 14;12(1):4378. Epub 2022 Mar 14.

Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.

The purpose of this study is to characterize demographically and genetically the Portuguese population with retinoblastoma; to report the clinical stage at presentation and its impact on survival and ocular preservation rate and, finally, to assess the incidence of retinoblastoma in Portugal. Retrospective observational study including children consecutively diagnosed with retinoblastoma at the Portuguese National Referral Center of Intraocular Tumors, between October 2015 and October 2020. Twenty-eight children were diagnosed with retinoblastoma at our center, 15 hereditary from which 12 presented with bilateral retinoblastoma and 3 were unilateral. Read More

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Imaging Findings of Pediatric Orbital Masses and Tumor Mimics.

Radiographics 2022 May-Jun;42(3):880-897. Epub 2022 Mar 4.

From the Departments of Radiology (A.K.J., J.B.G., L.J.E., G.B.L., J.C.B., W.B., V.M.S.), Ophthalmology (L.A.D.), Neurology (G.F.K.), Neurosurgery (W.B.), and Radiation Oncology (N.N.L.), Mayo Clinic, 200 1st St SW, Rochester, MN 55905.

Pediatric orbital masses are not common but encompass a wide spectrum of benign and malignant entities that range from developmental anomalies to primary and secondary orbital malignancies and metastatic disease. Certain orbital tumors are unique to pediatric patients, such as retinoblastoma and neuroblastoma. Clinical symptoms and signs are often insufficient to differentiate between orbital lesions, and imaging is essential for narrowing the diagnostic considerations and determining the most appropriate management strategy. Read More

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Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes.

Genome Biol 2022 03 3;23(1):70. Epub 2022 Mar 3.

Department of Life Sciences, Chung-Ang University, Seoul, 06974, South Korea.

Background: Cohesin is a chromosome-associated SMC-kleisin complex that mediates sister chromatid cohesion, recombination, and most chromosomal processes during mitosis and meiosis. However, it remains unclear whether meiosis-specific cohesin complexes are functionally active in mitotic chromosomes.

Results: Through high-resolution 3D-structured illumination microscopy (3D-SIM) and functional analyses, we report multiple biological processes associated with the meiosis-specific cohesin components, α-kleisin REC8 and STAG3, and the distinct loss of function of meiotic cohesin during the cell cycle of embryonic stem cells (ESCs). Read More

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Improvement of quality of life by conservative management of thoracic scoliosis at 172°: a case report.

Eric Chun-Pu Chu

J Med Life 2022 Jan;15(1):144-148

New York Chiropractic and Physiotherapy Centre, Hong Kong, China.

Adult scoliosis is a sideways curvature of the spine causing bilateral lower back pain and paresthesia of the lower limbs. Conservative treatment for scoliosis is primarily performed for youth, but scoliosis can be deteriorating as the patient ages. Rare, severe scoliosis with a Cobb angle over 40 degrees with respiratory difficulties leaves open surgery as the only option. Read More

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January 2022

Diagnostic accuracy of B-scan in predicting retinoblastoma in children, taking Magnetic Resonance Imaging of orbits as gold standard.

J Pak Med Assoc 2021 Jan;71(1(B)):349-351

Foundation University, Rawalpindi, Pakistan.

The objective of this study was to determine the diagnostic accuracy of B-scan in predicting retinoblastoma (Rb) taking Magnetic Resonance Imaging (MRI) as a gold standard. A cross-sectional validation study was conducted in the Radiology Department of Fauji Foundation Hospital from May 20 to Nov 20, 2017. Children fulfilling the inclusion criteria were selected after informed consent and detailed history was taken for investigation of Rb. Read More

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January 2021

Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy.

Drug Deliv 2022 Dec;29(1):519-533

Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.

Retinoblastoma (RB) is a malignant intraocular neoplasm that occurs in children. Diagnosis and therapy are frequently delayed, often leading to metastasis, which necessitates effective imaging and treatment. In recent years, the use of nanoplatforms allowing both imaging and targeted treatment has attracted much attention. Read More

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December 2022

Correspondence on 'Intra-arterial chemotherapy for retinoblastoma: an updated systematic review and meta-analysis' by Ravindran .

J Neurointerv Surg 2022 06 11;14(6):e6. Epub 2022 Jan 11.

Department of Ophthalmology and Visual Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada

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