903 results match your criteria Retinoblastoma Imaging


The University of California, San Francisco Documentation System for Retinoblastoma: Preparing to Improve Staging Methods for This Disease.

Ocul Oncol Pathol 2019 Jan 14;5(1):36-45. Epub 2018 Jun 14.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Background/aims: Current retinoblastoma staging systems do not adequately describe the disease, especially in eyes with multiple tumors. The aims of this study were to develop methods for documenting individual tumors and to score disease burden over time.

Methods: A coding system was devised to describe each tumor according to affected eye, meridian, anteroposterior location, activity, growth pattern, type of seed, and treatment. Read More

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https://www.karger.com/Article/FullText/488147
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http://dx.doi.org/10.1159/000488147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341334PMC
January 2019
3 Reads

A Tale of Absent Crystalline Lens in an Eye with Retinoblastoma.

Ocul Oncol Pathol 2018 Jun 19;4(4):250-253. Epub 2018 Jan 19.

Department of Vitreoretina and Oncology, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To report the clinicopathological correlation of absent crystalline lens in an eye with retinoblastoma.

Methods: A 1-year-old female child was brought to our patient services for pain and swelling in the right eye since the past few months. The child was diagnosed to have bilateral retinoblastoma and was suspected to have absence of crystalline lens in the right eye on the basis of clinical findings and ocular imaging. Read More

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https://www.karger.com/Article/FullText/484983
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http://dx.doi.org/10.1159/000484983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322079PMC
June 2018
4 Reads

Hyperreflective Vitreous Opacities on Optical Coherence Tomography in a Patient With Bilateral Retinoblastoma.

Ophthalmic Surg Lasers Imaging Retina 2019 Jan;50(1):50-52

An investigational, portable spectral-domain optical coherence tomography (SD-OCT) unit revealed small hyperreflective opacities in both eyes of a patient with bilateral retinoblastoma. There was no evidence of vitreous seeding on ophthalmoscopy of either eye. Although the opacities may initially raise concern for potential vitreous seeding, this report suggests alternate potential etiologies for such opacities, which were also seen on imaging of a cohort of normal eyes in pediatric patients. Read More

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http://dx.doi.org/10.3928/23258160-20181212-08DOI Listing
January 2019
1 Read

Diagnosis of Bilateral Retinocytoma in an Adolescent Patient Using Multimodal Imaging and Genetic Testing.

Ophthalmic Surg Lasers Imaging Retina 2018 Oct;49(10):812-814

A 12-year-old male presented for evaluation of asymptomatic bilateral retinal tumors. Both eyes contained whitish-gray retinal tumors with intralesional calcifications. Enhanced depth optical coherence tomography and high-resolution (20 MHz) ultrasonography narrowed the differentiation diagnosis to astrocytic hamartoma versus retinocytoma. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2018
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http://dx.doi.org/10.3928/23258160-20181002-11DOI Listing
October 2018
8 Reads

Early monocular enucleation selectively disrupts neural development of face perception in the occipital face area.

Exp Eye Res 2018 Oct 3. Epub 2018 Oct 3.

Centre for Vision Research and Department of Psychology, York University, Toronto, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada. Electronic address:

Retinoblastoma generally occurs before 5 years of age and often requires enucleation (surgical removal of one eye) of the cancerous eye. We have previously shown using behavioural methods that this disruption in binocular vision during the critical period of visual development results in impaired face perception. In this case series study, we sought to determine the underlying neural correlates of this face perception deficit by examining brain activity in regions of cortex that preferentially respond to visual images of faces and places in 6 adults who had one eye enucleated early in life due to retinoblastoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183043
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http://dx.doi.org/10.1016/j.exer.2018.09.013DOI Listing
October 2018
2 Reads

Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.

Science 2018 10;362(6410):91-95

Department of Microbiology, Immunology, and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA 90095, USA.

The use of potent therapies inhibiting critical oncogenic pathways active in epithelial cancers has led to multiple resistance mechanisms, including the development of highly aggressive, small cell neuroendocrine carcinoma (SCNC). SCNC patients have a dismal prognosis due in part to a limited understanding of the molecular mechanisms driving this malignancy and the lack of effective treatments. Here, we demonstrate that a common set of defined oncogenic drivers reproducibly reprograms normal human prostate and lung epithelial cells to small cell prostate cancer (SCPC) and small cell lung cancer (SCLC), respectively. Read More

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http://www.sciencemag.org/lookup/doi/10.1126/science.aat5749
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http://dx.doi.org/10.1126/science.aat5749DOI Listing
October 2018
7 Reads

Lanthanide phosphate (LnPO ) rods as bio-probes: A systematic investigation on structural, optical, magnetic, and biological characteristics.

J Biomed Mater Res B Appl Biomater 2018 Sep 28. Epub 2018 Sep 28.

Centre for Nanoscience and Technology, Pondicherry University, 605014, Puducherry, India.

The proposed work involves an exclusive study on the synthesis protocol, crystal structure analysis, and imaging contrast features of unique lanthanide phosphates (LnPO ). XRD and Raman spectra affirmed the ability of the proposed synthesis technique to achieve unique LnPO devoid of impurities. The crystal structure analysis confirms the P121/c1 space setting of NdPO , EuPO , GdPO , and TbPO that all uniformly crystallizes in monoclinic unit cell. Read More

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http://doi.wiley.com/10.1002/jbm.b.34229
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http://dx.doi.org/10.1002/jbm.b.34229DOI Listing
September 2018
2 Reads

Retinoblastoma Intrinsically Regulates Niche Cell Quiescence, Identity, and Niche Number in the Adult Drosophila Testis.

Cell Rep 2018 Sep;24(13):3466-3476.e8

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

Homeostasis in adult tissues depends on the precise regulation of stem cells and their surrounding microenvironments, or niches. Here, we show that the cell cycle inhibitor and tumor suppressor Retinoblastoma (RB) is a critical regulator of niche cells in the Drosophila testis. The testis contains a single niche, composed of somatic hub cells, that signals to adjacent germline and somatic stem cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183138
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http://dx.doi.org/10.1016/j.celrep.2018.08.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226258PMC
September 2018
1 Read

Conventional, diffusion, and permeability MR findings in ocular medulloepithelioma.

Neuroradiology 2018 Nov 19;60(11):1213-1222. Epub 2018 Sep 19.

Department of Ophthalmology, Referral Center for Retinoblastoma, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

Purpose: To describe the neuroradiological features of intraocular medulloepithelioma.

Methods: We retrospectively analyzed the clinical, histopathological, and MRI data of five children with medulloepithelioma. In addition to conventional images, DWI was performed in four patients and mean ADC was calculated; this was limited to the technique of this cohort of patients. Read More

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http://dx.doi.org/10.1007/s00234-018-2094-1DOI Listing
November 2018
1 Read

Cancers of the eye.

Cancer Metastasis Rev 2018 Dec;37(4):677-690

The New York Eye Cancer Center, Suite 5B, 115 East 61st Street, New York, NY, 10065, USA.

Ocular cancers are unique among the diseases of the eye, threatening both vision and life. In most cases, the diagnosis can be made utilizing a careful clinical history and specialized ocular examination. Eye cancer diagnosis relies heavily on imaging techniques such as high-frequency ultrasound, fluorescein angiography, anterior and posterior segment optical coherence tomography, computed tomography (CT), and magnetic resonance imaging (MRI). Read More

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http://link.springer.com/10.1007/s10555-018-9762-9
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http://dx.doi.org/10.1007/s10555-018-9762-9DOI Listing
December 2018
16 Reads

Targeting the Platelet-Derived Growth Factor-beta Stimulatory Circuitry to Control Retinoblastoma Seeds.

Invest Ophthalmol Vis Sci 2018 Sep;59(11):4486-4495

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, United States.

Purpose: Vitreous seeding remains the primary reason for treatment failure in eyes with retinoblastoma (Rb). Systemic and intra-arterial chemotherapy, each with its own inherent set of complications, have improved salvage rates for eyes with advanced disease, but the location and biology of vitreous seeds present a fundamental challenge in developing treatments with minimal toxicity and risk. The aim of this study was to target the platelet-derived growth factor (PDGF)- PDGF-receptor β (PDGFRβ) signaling pathway and investigate its role in the growth of Rb seeds, apoptotic activity, and invasive potential. Read More

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http://dx.doi.org/10.1167/iovs.18-24359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133233PMC
September 2018
4 Reads

Imaging Techniques in the Diagnosis and Management of Ocular Tumors: Prospects and Challenges.

AAPS J 2018 Sep 5;20(6):97. Epub 2018 Sep 5.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, P.O. Box 346, Ajman, United Arab Emirates.

Different types of imaging modalities are used in the diagnosis of ocular cancer. Selection of an imaging modality is based on the features of a tumor as well as the inherent characteristics of the imaging technique. It is vital to select an appropriate imaging modality in diagnosis of ocular tumor with confidence. Read More

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http://dx.doi.org/10.1208/s12248-018-0259-9DOI Listing
September 2018
7 Reads

Assessing the feasibility and validity of the Toronto Childhood Cancer Stage Guidelines: a population-based registry study.

Lancet Child Adolesc Health 2018 03 1;2(3):173-179. Epub 2018 Feb 1.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MD, USA.

Background: Cancer stage at diagnosis is crucial for assessing global efforts to increase awareness of childhood cancer and improve outcomes. However, consistent information on childhood cancer stage is absent from population cancer registries worldwide. The Toronto Childhood Cancer Stage Guidelines, compiled through an international consensus process, were designed to provide a standard framework for collection of information on stage at diagnosis of childhood cancers. Read More

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http://dx.doi.org/10.1016/S2352-4642(18)30023-3DOI Listing
March 2018
20 Reads

Incomprehensible treatment of retinoblastoma with high doses of vitamin C.

Bratisl Lek Listy 2018;119(8):513-515

Purposes: To inform about a case of neglected retinoblastoma that was left untreated for more than 3 years by parents. During this time period the local finding worsened from endophytic retinoblastoma group B according IIRC (ABC classification) to extraorbital propagation.

Background: Retinoblastoma is the most common intraocular tumor in childhood, that occurs approximately in 1 : 15-20 000 births worldwide. Read More

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http://dx.doi.org/10.4149/BLL_2018_094DOI Listing
January 2019
1 Read

Lurking below: massive choroidal invasion under a calcified tumor after attempted conservative therapy for retinoblastoma.

Ophthalmic Genet 2018 Oct 24;39(5):653-657. Epub 2018 Aug 24.

a USC Roski Eye Institute, Department of Ophthalmology , University of Southern California , Los Angeles , CA , USA.

Background: In the conservative management of retinoblastoma, detection of tumor activity beneath large, calcified tumors presents a challenging aspect of care as local consolidation is limited in this area. Routine imaging modalities, including magnetic resonance imaging, B-scan ultrasound, and optical coherence tomography, are also limited in providing appropriate surveillance for recurrent disease.

Materials And Methods: Medical records were reviewed to evaluate patients' demographic data, ophthalmic exams, imaging studies, and histopathologic reports. Read More

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http://dx.doi.org/10.1080/13816810.2018.1513535DOI Listing
October 2018
14 Reads

Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling.

Clin Cancer Res 2018 Dec 21;24(23):6028-6039. Epub 2018 Aug 21.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana.

Purpose: Ewing sarcoma (ES) is a rare and highly malignant cancer that occurs in the bone and surrounding tissue of children and adolescents. The fusion transcription factor that drives ES pathobiology was previously demonstrated to modulate cyclin D1 expression. In this study, we evaluated abemaciclib, a small-molecule CDK4 and CDK6 (CDK4 and 6) inhibitor currently under clinical investigation in pediatric solid tumors, in preclinical models of ES. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279561PMC
December 2018
18 Reads

Successful treatment of metastatic congenital intraocular medulloepithelioma with neoadjuvant chemotherapy, enucleation and superficial parotidectomy.

Am J Ophthalmol Case Rep 2018 Sep 21;11:124-127. Epub 2018 Jun 21.

Department of Ophthalmology and Vision Science, University of California at Davis, Sacramento, CA, USA.

Purpose: To report a case of metastatic intraocular medulloepithelioma successfully treated with neoadjuvant chemotherapy, superficial parotidectomy, and enucleation.

Observations: A 5-year-old male with history of cataract surgery, glaucoma drainage device, endocyclophotocoagulation, scleral patch grafting, and chronic posterior "inflammation" in a blind left eye presented with a rapidly enlarging painful mass under the left upper eyelid. Biopsy of the conjunctival mass and fine needle aspiration of an enlarged preauricular lymph node revealed medulloepithelioma, which was also seen in the left parotid gland on positron emission tomography (PET) scan. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097803PMC
September 2018
3 Reads

Magnetic resonance imaging for tumor restaging after chemotherapy in retinoblastoma with optic nerve invasion.

Ophthalmic Genet 2018 Oct 8;39(5):584-588. Epub 2018 Aug 8.

d Ocular Pathology Service, Dr. Rajendra Prasad Center for Ophthalmic Sciences , All India Institute of Medical Sciences , New Delhi , India.

Purpose: Extraocular retinoblastoma with optic nerve invasion is treated by a multimodal protocol consisting of neoadjuvant chemotherapy, enucleation, and adjuvant therapy. This study was conducted to evaluate the performance of magnetic resonance imaging (MRI) used for tumor restaging in these children after systemic chemotherapy administration.

Methods: Contrast-enhanced MRI scan of orbits and brain was performed at diagnosis and patients were treated with neoadjuvant chemotherapy. Read More

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http://dx.doi.org/10.1080/13816810.2018.1502790DOI Listing
October 2018
14 Reads
1.230 Impact Factor

Point-of-Care Ultrasound Diagnosis of Retinoblastoma in the Emergency Department.

Pediatr Emerg Care 2018 Aug;34(8):599-601

Department of Emergency Medicine and Trauma Center, Meyer University Children's Hospital, Florence, Italy.

An 18-month-old girl presented to the emergency department with the chief complaint of squinting. The right eye demonstrated esotropia, heterochromia, and anisocoria. Ocular point-of-care ultrasound facilitated the rapid diagnosis of retinoblastoma, which was confirmed by computed tomography scan and orbital magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001575DOI Listing
August 2018
1 Read

Protective effect of roscovitine against rotenone-induced parkinsonism.

Restor Neurol Neurosci 2018 ;36(5):629-638

Department of Neurology, Affiliated Hospital of Binzhou Medical University, Shandong Province, China.

Background: Protective effect of roscovitine and deregulation of the p-RB/E2F1 have not been well studied in PD models generated by repeated oral administration of rotenone.

Objective: These experiments evaluated the effects of repeated oral gavage of rotenone on the activation of p-RB/E2F1 and the effects of roscovitine on the regulation of dopaminergic neuronal injury and the behavior of PD in mice.

Methods: Using 2. Read More

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/RNN-180817DOI Listing
November 2018
4 Reads

[Primary meningioma of the optical nerve sheet in infancy as initial presentation of neurofibromatosis type 2].

Pathologe 2018 Jul 26. Epub 2018 Jul 26.

Institut für Pathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland.

Intraorbital meningiomas are rare tumors, making up less than 4% of all intraorbital tumors. Intraorbital meningiomas of childhood are curiosities with only few documented cases. We present the case of an 8‑month-old male infant, presenting with strabismus and nystagmus. Read More

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http://dx.doi.org/10.1007/s00292-018-0464-4DOI Listing
July 2018
4 Reads

Retinoblastoma membrane models and their interactions with porphyrin photosensitisers: An infrared microspectroscopy study.

Chem Phys Lipids 2018 Sep 17;215:34-45. Epub 2018 Jul 17.

Lip(Sys)(2), Chimie Analytique Pharmaceutique, Univ. Paris-Sud, Université Paris-Saclay, F-92290 Châtenay-Malabry cedex, France. Electronic address:

Fourier Transform Infrared (FTIR) microspectroscopy was used to highlight the interactions between two photosensitisers (PS) of different geometries, TPPmOH4 and a glycoconjugated analogous, TPPDegMan, and lipid bilayers modelling retinoblastoma cell membranes. Retinoblastoma is a rare disease occurring in young infants, for whom conservative treatments may present harmful side-effects. Photodynamic therapy (PDT) is expected to induce less side-effects, as the photosensitiser is only activated when the tumour is illuminated. Read More

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http://dx.doi.org/10.1016/j.chemphyslip.2018.07.003DOI Listing
September 2018
178 Reads

MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin.

Mol Med Rep 2018 Sep 16;18(3):3099-3105. Epub 2018 Jul 16.

Department of Pediatrics, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China.

MicroRNAs (miRNAs/miRs) serve important roles in regulating gene expression by directly binding to the 3'‑untranslated regions of target genes. Multiple miRNAs are dysregulated in retinoblastoma (RB) and their dysregulation is closely related to RB malignancy. Therefore, exploring the detailed roles of miRNAs in RB is valuable to facilitate the development of effective therapeutic targets for patients with this disease. Read More

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http://dx.doi.org/10.3892/mmr.2018.9295DOI Listing
September 2018
1 Read

Optical Coherence Tomography of Small Retinoblastoma.

Asia Pac J Ophthalmol (Phila) 2018 Sep-Oct;7(5):301-306. Epub 2018 Jul 9.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.

Purpose: To investigate hand-held optical coherence tomography (HH-OCT) characteristics of small (<1 mm thickness) retinoblastoma.

Design: Retrospective observational case series.

Methods: Patient and tumor data were extracted from the medical record and analyzed along with HH-OCT scans. Read More

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http://dx.doi.org/10.22608/APO.2018189DOI Listing
October 2018
1 Read

Personalized Anatomic Eye Model From T1-Weighted Volume Interpolated Gradient Echo Magnetic Resonance Imaging of Patients With Uveal Melanoma.

Int J Radiat Oncol Biol Phys 2018 Nov 14;102(4):813-820. Epub 2018 May 14.

Radiology Department, Lausanne University Hospital, Lausanne, Switzerland; Medica Image Analysis Laboratory, Centre d'Imagerie BioMédicale, University of Lausanne, Lausanne, Switzerland; Signal Processing Laboratory, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Purpose: We present a 3-dimensional patient-specific eye model from magnetic resonance imaging (MRI) for proton therapy treatment planning of uveal melanoma (UM). During MRI acquisition of UM patients, the point fixation can be difficult and, together with physiological blinking, can introduce motion artifacts in the images, thus challenging the model creation. Furthermore, the unclear boundary of the small objects (eg, lens, optic nerve) near the muscle or of the tumors with hemorrhage and tantalum clips can limit model accuracy. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.05.004DOI Listing
November 2018
7 Reads
4.260 Impact Factor

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation.

Dis Model Mech 2018 06 15;11(6). Epub 2018 Jun 15.

Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA

In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish () somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish brain tumors caused by TALEN or CRISPR targeting are histologically similar to human central nervous system primitive neuroectodermal tumors (CNS-PNETs). Like the human oligoneural CNS-PNET subtype, zebrafish tumors show elevated expression of neural progenitor transcription factors , , and the receptor tyrosine kinase oncogene. Read More

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http://dx.doi.org/10.1242/dmm.034124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031359PMC
June 2018
21 Reads

Retinoblastoma in a 37-year-old man: Clinical aspect, imaging and histological features.

J Fr Ophtalmol 2018 Jun 15;41(6):e265-e269. Epub 2018 Jun 15.

National institute of ophthalmology, university of Tunis El Manar, faculty of medicine of Tunis (FMT), Tunis, Tunisia. Electronic address:

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http://dx.doi.org/10.1016/j.jfo.2017.09.026DOI Listing
June 2018
1 Read

The predictive value of magnetic resonance imaging of retinoblastoma for the likelihood of high-risk pathologic features.

Eur J Ophthalmol 2018 Jun 1:1120672118781200. Epub 2018 Jun 1.

1 Department of Surgery/Ophthalmology, King Hussein Cancer Center, Amman, Jordan.

Purpose: To evaluate the predictive value of magnetic resonance imaging in retinoblastoma for the likelihood of high-risk pathologic features.

Methods: A retrospective study of 64 eyes enucleated from 60 retinoblastoma patients. Contrast-enhanced magnetic resonance imaging was performed before enucleation. Read More

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http://dx.doi.org/10.1177/1120672118781200DOI Listing
June 2018
5 Reads

Diffusion-Weighted Imaging Changes in a Child With Posterior Ischemic Optic Neuropathy.

Pediatr Neurol 2018 Jul 4;84:49-52. Epub 2018 Apr 4.

Department of Neurology, Boston Children's Hospital, Boston, Massachusetts; Stroke and Cerebrovascular Center, Boston Children's Hospital, Boston, Massachusetts; Department of Radiology, Boston Children's Hospital, Boston, Massachusetts; Department of Psychiatry, Boston Children's Hospital, Boston, Massachusetts.

Background: Posterior ischemic optic neuropathy results from ischemia of the retrobulbar aspect of the optic nerve. It presents as acute loss of vision without optic disc swelling. This is rare in children, with only seven cases reported to date. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.03.014DOI Listing
July 2018
2 Reads

Upregulated miR-221/222 promotes cell proliferation and invasion and is associated with invasive features in retinoblastoma.

Cancer Biomark 2018 ;22(4):621-629

Department of Nuclear medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shangdong, China.

Background And Objectives: MicroRNA (miR-221/222) is frequently overexpressed in many cancers and is associated with poor prognosis. However, the role of miR-221/222 in retinoblastoma (RB) remains unclear. This study aimed to detect the clinical significance of miR-221/222 in RB patients and explore its role in RB cells in vitro. Read More

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http://dx.doi.org/10.3233/CBM-170721DOI Listing
November 2018
1 Read

MR Imaging Features of Retinoblastoma: Association with Gene Expression Profiles.

Radiology 2018 08 1;288(2):506-515. Epub 2018 May 1.

From the Departments of Radiology and Nuclear Medicine (R.W.J., M.C.d.J., J.A.C., P.d.G.), Clinical Genetics (I.E.K., J.C.D.), Ophthalmology (A.C.M.), Pathology (P.v.d.V.), Pediatric Oncology (J.C.), and Epidemiology and Biostatistics (I.E.), VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, the Netherlands; European Retinoblastoma Imaging Collaboration (ERIC) (R.W.J., M.C.d.J., S.S., S.G., H.J.B., P.M., P.G., J.A.C., P.d.G.); Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany (S.S., S.G.); Department of Radiology, Institut Curie, Paris, France and Paris Sciences et Lettres Research University, Paris, France (H.J.B.); Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland (P.M.); and Unit of Neuroimaging and Neurointervention, Department of Neurosciences, Siena University Hospital, Siena, Italy (P.G.).

Purpose To identify associations between magnetic resonance (MR) imaging features and gene expression in retinoblastoma. Materials and Methods A retinoblastoma MR imaging atlas was validated by using anonymized MR images from referral centers in Essen, Germany, and Paris, France. Images were from 39 patients with retinoblastoma (16 male and 18 female patients [the sex in five patients was unknown]; age range, 5-90 months; inclusion criterion: pretreatment MR imaging). Read More

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http://dx.doi.org/10.1148/radiol.2018172000DOI Listing
August 2018
7 Reads

MR Imaging Features May Help Predict Gene Expression in Retinoblastoma, with Possible Therapeutic Implications.

Authors:
Timothy N Booth

Radiology 2018 08 1;288(2):516-517. Epub 2018 May 1.

From the Department of Radiology, Children's Health of Dallas, University of Texas Southwestern Medical Center, 1935 Medical District Dr, Dallas, TX 75235.

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http://dx.doi.org/10.1148/radiol.2018180709DOI Listing
August 2018
2 Reads

Characterization, treatment and prognosis of retinoblastoma with central nervous system metastasis.

BMC Ophthalmol 2018 Apr 23;18(1):107. Epub 2018 Apr 23.

Department of Pediatrics, Beijing Tongren Hospital, West South road 2, Yizhuang Economic and Technological Development Zone, Daxing District, Beijing, 100176, China.

Background: Retinoblastoma is the most common primary intraocular tumor and more and more attention has been paid to the developing countries. This study was aimed to evaluate the clinical features, treatment, and prognosis of retinoblastoma patients with central nervous system (CNS) metastasis in Beijing Tongren Hospital, one of the largest tertiary eye centers in China.

Methods: Clinical data of 31 consecutive retinoblastoma patients with CNS metastases, who were diagnosed at the Department of Pediatrics in Beijing Tongren Hospital between September 2005 and December 2015, were retrospective analyzed. Read More

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http://dx.doi.org/10.1186/s12886-018-0772-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914066PMC
April 2018
4 Reads

Iris Hypoplasia as the Presenting Sign of Retinoblastoma in a Child With a 13q Deletion.

J Pediatr Ophthalmol Strabismus 2018 Apr 23;55:e10-e13. Epub 2018 Apr 23.

Germline partial chromosomal deletions of the entire RB1 gene (13q deletions), account for 6% of the RB1 mutational spectrum. The authors report the rare case of one patient with suspected bilateral iris heterochromia who actually had iris hypoplasia (often masquerading as heterochromia) and bilateral retinoblastoma, due to 13q deletion syndrome. [J Pediatr Ophthalmol. Read More

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http://dx.doi.org/10.3928/01913913-20180215-02DOI Listing
April 2018
30 Reads

Evaluation of recurrence of musculoskeletal tumors with thallium-201 scintigraphy plus SPECT/CT in pediatric population.

Bol Med Hosp Infant Mex 2018 ;75(1):31-40

Departamento de Medicina Nuclear e Imagen Molecular, Instituto Nacional de Cancerología. Ciudad de México, México.

Background: Imaging studies, particularly simple and contrast-enhanced tomography, constitute the first diagnostic approach to detect recurrence of musculoskeletal tumors. The aim of the present retrospective study was to demonstrate the usefulness of scintigraphy plus SPECT/CT (single photon emission computed tomography) with thallium-201 (Tl) in the evaluation of malignant musculoskeletal tumors with suspicion of recurrence or metastatic disease.

Methods: Eight weeks after the last therapy, 72 scintigraphy and SPECT/CT studies were performed to assess regional recurrence and metastatic disease in 42 patients with different types of malignant musculoskeletal tumors, such as osteosarcoma, Ewing's sarcoma, rhabdomyosarcoma, retinoblastoma, synovial sarcoma, and Wilms tumor at the Hospital Infantil de México Federico Gómez. Read More

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http://dx.doi.org/10.24875/BMHIM.M18000004DOI Listing
January 2018
4 Reads

Effects on Periocular Tissues after Proton Beam Radiation Therapy for Intraocular Tumors.

J Korean Med Sci 2018 Apr 16;33(16):e120. Epub 2018 Apr 16.

Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.

Background: To present our experience on orbital and periorbital tissue changes after proton beam radiation therapy (PBRT) in patients with intraocular tumors, apart from treatment outcomes and disease control.

Methods: Medical records of 6 patients with intraocular tumors who had been treated with PBRT and referred to oculoplasty clinics of two medical centers (Seoul National University Hospital and Seoul Metropolitan Government-Seoul National University Boramae Medical Center) from October 2007 to September 2014 were retrospectively reviewed. The types of adverse effects associated with PBRT, their management, and progression were analyzed. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897156PMC
April 2018
3 Reads

Retinoblastoma in an Adult.

J Cytol 2018 Apr-Jun;35(2):120-124

Department of Pathology, Dr B.S. Ambedkar Hospital, New Delhi, India.

Retinoblastoma is a rare malignant tumor of the retina usually seen in children before 5 years of age. The tumor is extremely rare in adults. We report here an unusual case of retinoblastoma in a 55-year-old adult female who presented to us with an orbital mass at a late stage of the disease. Read More

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http://dx.doi.org/10.4103/JOC.JOC_230_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885601PMC
April 2018
4 Reads

Autochthonous tumors driven by loss have an ongoing requirement for the RBP2 histone demethylase.

Proc Natl Acad Sci U S A 2018 04 2;115(16):E3741-E3748. Epub 2018 Apr 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215;

Inactivation of the retinoblastoma gene () product, pRB, is common in many human cancers. Targeting downstream effectors of pRB that are central to tumorigenesis is a promising strategy to block the growth of tumors harboring loss-of-function mutations. One such effector is retinoblastoma-binding protein 2 (RBP2, also called JARID1A or KDM5A), which encodes an H3K4 demethylase. Read More

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http://dx.doi.org/10.1073/pnas.1716029115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910822PMC
April 2018
9 Reads

Iterative Variance Stabilizing Transformation Denoising of Spectral Domain Optical Coherence Tomography Images Applied to Retinoblastoma.

Ophthalmic Res 2018 26;59(3):164-169. Epub 2018 Mar 26.

INSERM, U1196, Université Paris Sud, Université Paris-Saclay, Orsay, France.

Background: Due to the presence of speckle Poisson noise, the interpretation of spectral domain-optical coherence tomography (SD-OCT) images frequently requires the use of data averaging to improve the signal-to-noise ratio. This implies long acquisition times and requires patient sedation in some cases. Iterative variance stabilizing transformation (VST) is a possible approach by which to remove speckle Poisson noise on single images. Read More

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http://dx.doi.org/10.1159/000486283DOI Listing
June 2018
16 Reads

Coats' disease - disease of the eye rarely encountered by pathologists.

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):98-100

Department of Ophtholmology, Fr. Muller Medical College, Mangalore, Karnataka, India.

Coats' Disease is an idiopathic condition of the eye affecting young children although it can be seen in adults. Most patients present early in life with unilateral decreased vision, strabismus or leukocoria. The most important differential diagnosis is unilateral retinoblastoma. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_826_16DOI Listing
November 2018
3 Reads

Clinical pattern of Retinoblastoma in Pakistani population: Review of 403 eyes in 295 patients.

J Pak Med Assoc 2018 Mar;68(3):376-380

Department of Ophthalmology, Dow University of Health Sciences, Karachi, Pakistan.

Objective: To document clinical pattern of retinoblastoma in Pakistani population.

Methods: This retrospective study, which was conducted at Department of Ophthalmology, Dow University of Health Sciences, Karachi, reviewed clinical records of patients with retinoblastoma from 1997 to 2012. Staging of disease was done by referring to retinal diagrams, RetCam images, and first magnetic resonance imaging. Read More

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March 2018
5 Reads

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway.

Cancer Res 2018 Jun 7;78(11):2911-2924. Epub 2018 Mar 7.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Bone metastasis from prostate cancer can occur years after prostatectomy, due to reactivation of dormant disseminated tumor cells (DTC) in the bone, yet the mechanism by which DTCs are initially induced into a dormant state in the bone remains to be elucidated. We show here that the bone microenvironment confers dormancy to C4-2B4 prostate cancer cells, as they become dormant when injected into mouse femurs but not under the skin. Live-cell imaging of dormant cells at the single-cell level revealed that conditioned medium from differentiated, but not undifferentiated, osteoblasts induced C4-2B4 cellular quiescence, suggesting that differentiated osteoblasts present locally around the tumor cells in the bone conferred dormancy to prostate cancer cells. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984689PMC
June 2018
11 Reads

The Interdisciplinary Diagnosis and Treatment of Intraocular Tumors.

Dtsch Arztebl Int 2018 Feb;115(7):106-111

Department of Ophthalmology, Tumor Center Western Germany, Essen University Hospital; Department of Internal Medicine (Tumor Research), Tumor Center Western Germany, Essen University Hospital; Department of Pediatrics III, Tumor Center Western Germany, Essen University Hospital; Institute for Human Genetics, Tumor Center Western Germany, Essen University Hospital.

Background: Recent years have seen major changes in the diagnosis and treatment of solid intraocular tumors, mainly owing to an improved molecular biological understanding of their pathogenesis, new therapeutic approaches for the local treatment of tumors in children, and long-term follow-up observations in clinical trials.

Methods: This review is based on pertinent publications retrieved by a selective search in PubMed.

Results: Retinoblastoma is the most common type of primary intraocular tumor, with approximately 8000 new cases per year around the world, while malignant melanoma of the uvea is the most common primary intraocular tumor in adults, with approximately 7000 new cases per year around the world. Read More

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http://dx.doi.org/10.3238/arztebl.2018.0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842342PMC
February 2018
3 Reads

Multimodal imaging in a case of retinocytoma.

Indian J Ophthalmol 2018 Mar;66(3):447-448

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/ijo.IJO_908_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859606PMC
March 2018
4 Reads

Possible retinoblastoma?

Indian J Ophthalmol 2018 Mar;66(3):359

Wills Eye Hospital, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.4103/ijo.IJO_1310_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859587PMC
March 2018
2 Reads

A laser-activated multifunctional targeted nanoagent for imaging and gene therapy in a mouse xenograft model with retinoblastoma Y79 cells.

Acta Biomater 2018 04 13;70:211-226. Epub 2018 Feb 13.

Department of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China. Electronic address:

Retinoblastoma (RB) is the most common intraocular malignancy of childhood that urgently needs early detection and effective therapy methods. The use of nanosized gene delivery systems is appealing because of their highly adjustable structure to carry both therapeutic and imaging agents. Herein, we report a folic acid (FA)-modified phase-changeable cationic nanoparticle encapsulating liquid perfluoropentane (PFP) and indocyanine green (ICG) (FA-CN-PFP-ICG, FCNPI) with good plasmid DNA (pDNA) carrying capacity, favorable biocompatibility, excellent photoacoustic (PA) and ultrasound (US) contrast, enhanced gene transfection efficiency and therapeutic effect. Read More

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http://dx.doi.org/10.1016/j.actbio.2018.02.006DOI Listing
April 2018
9 Reads
6.030 Impact Factor

HAND-HELD OPTICAL COHERENCE TOMOGRAPHY MONITORING OF CHEMORESISTANT RETINOBLASTOMA.

Retin Cases Brief Rep 2018 Feb 13. Epub 2018 Feb 13.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose: Retinoblastoma (Rb) is a potentially fatal intraocular malignancy in children, and hand-held optical coherence tomography (HH-OCT) can assist in submillimeter detection and monitoring after treatment of Rb. Retinoblastoma located in the macula, or those with chemoresistance, can be among the most difficult to manage. We describe HH-OCT features in a case of chemoresistant macular Rb that eventually responded to plaque radiotherapy after failing intravenous chemotherapy and intraarterial chemotherapy. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000714DOI Listing
February 2018

Improved procedural safety following protocol changes for selective ophthalmic arterial infusion of chemotherapy for treatment of ocular retinoblastoma.

Interv Neuroradiol 2018 Jun 13;24(3):345-350. Epub 2018 Feb 13.

1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.

Purpose The aim was to evaluate the impact of protocol changes in selective ophthalmic arterial infusion (SOAI) for treatment of retinoblastoma (Rb). Methods A retrospective review was completed of 35 patients with Rb who were treated with SOAI between March 2010 and January 2017. Treatment details were tabulated for each SOAI session. Read More

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http://dx.doi.org/10.1177/1591019918755088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967188PMC
June 2018
6 Reads
0.730 Impact Factor

[Clinicopathologic features of atypical spindle cell lipomatous tumor].

Zhonghua Bing Li Xue Za Zhi 2018 Feb;47(2):99-104

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the clinicopathologic characteristics, immunophenotype, differential and diagnostic features of atypical spindle cell lipomatous tumor (ASLT). Three cases of ASLT were collected from January 2010 to March 2017 at Zhejiang Provincial People's Hospital. The clinical and imaging features, histomorphology, immunophenotype and prognosis were analyzed. Read More

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http://doi.med.wanfangdata.com.cn/10.3760/cma.j.issn.0529-58
Publisher Site
http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.02.004DOI Listing
February 2018
17 Reads