1,039 results match your criteria Retinoblastoma Imaging


Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma: a meta-analysis.

Acta Ophthalmol 2021 May 3. Epub 2021 May 3.

Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada.

Purpose: To determine the risk of patients with an early diagnosis of heritable retinoblastoma being diagnosed with TRb (or pineoblastoma) asynchronously in a later stage and its effect on screening.

Methods: We updated the search (PubMed and Embase) for published literature as performed by our research group in 2014 and 2019. Trilateral retinoblastoma (TRb) patients were eligible for inclusion if identifiable as unique and the age at which TRb was diagnosed was available. Read More

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Eye Tumors in Childhood as First Sign of Tumor Predisposition Syndromes: Insights from an Observational Study Conducted in Germany and Austria.

Cancers (Basel) 2021 Apr 14;13(8). Epub 2021 Apr 14.

Institute of Human Genetics, Medical Faculty, University Duisburg-Essen, 45122 Essen, Germany.

Retinoblastoma and other eye tumors in childhood are rare diseases. Many eye tumors are the first signs of a genetic tumor predisposition syndrome and the affected children carry a higher risk of developing other cancers later in life. Clinical and genetic data of all children with eye tumors diagnosed between 2013-2018 in Germany and Austria were collected in a multicenter prospective observational study. Read More

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Clinical and magnetic resonance imaging features of 14 patients with trilateral retinoblastoma.

Quant Imaging Med Surg 2021 Apr;11(4):1458-1469

Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Our study aimed to comprehensively investigate the age of onset, magnetic resonance imaging (MRI) features, and prognosis of children with trilateral retinoblastoma (TRB).

Methods: We included 14 patients with TRB diagnosed or followed up in our hospital. The age of onset and MRI features of the intraocular tumor and intracranial lesions were evaluated. Read More

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Screening for Retinoblastoma: A Systematic Review of Current Strategies.

Asia Pac J Ophthalmol (Phila) 2021 Mar-Apr 01;10(2):192-199

Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, India.

Purpose: The aim of this study was to review the literature on various screening programs, devices, and applications described for the early detection of retinoblastoma.

Design: Systematic review article.

Methods: A PubMed® search was performed to identify articles published with specific reference to screening of neonates, infants and children for retinoblastoma. Read More

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Prenatal diagnosis of bilateral retinoblastomas by multimodality fetal imaging: case report and review of the literature.

Clin Imaging 2021 Mar 20;78:121-126. Epub 2021 Mar 20.

Phoenix Children's Hospital, Department of Radiology, United States of America; University of Arizona School of Medicine, Department of Child Health, United States of America; University of Arizona School of Medicine, Department of Radiology, United States of America; Mayo Clinic, Department of Radiology, United States of America; Creighton University, Department of Radiology, United States of America.

Retinoblastoma is the prototypic genetic tumor. Caused by mutations in the RB1 gene, retinoblastomas are heritable in 40% of the cases and, in such cases, tumors are bilateral in 80%, unilateral in 15%, and trilateral in 5% of the cases. Trilateral retinoblastoma is a term that describes bilateral retinoblastomas plus a midline suprasellar or pineal neuroectodermal tumor. Read More

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Accuracy of Computed Tomography and Magnetic Resonance Imaging for Detection of Pathologic Risk Factors in Patients Diagnosed with Retinoblastoma.

Curr Eye Res 2021 Mar 22:1-7. Epub 2021 Mar 22.

Department of Ophthalmology, Chiang Mai University, Chiang Mai, Thailand.

: To assess and compare the diagnostic accuracy of magnetic resonance imaging (MRI) and computed tomography (CT) for detecting the extent of tumor invasion in eyes with advanced retinoblastoma prior to enucleation using histopathologic analysis as a reference.: A total of 56 patients (68 eyes) enucleated for retinoblastoma were reviewed. Eyes with complete data (CT 28, MRI 16) were included for analysis. Read More

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Bilateral Persistent Hyperplastic Primary Vitreous: A Case Report and Review of the Literature.

Cureus 2021 Feb 3;13(2):e13105. Epub 2021 Feb 3.

Medicine, Nishtar Medical University, Multan, PAK.

Bilateral persistent hyperplastic primary vitreous (PHPV) is a rare ocular disorder. Its clinical manifestations include bilateral corneal haziness, microphthalmia, and cataract. It is the second most common cause of leukocoria after retinoblastoma. Read More

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February 2021

Coincidental ocular findings during retinopathy of prematurity telescreening of 9105 neonates.

Eur J Ophthalmol 2021 Mar 15:11206721211001318. Epub 2021 Mar 15.

Department of Paediatric Retina & Ocular Oncology, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.

Purpose: To describe the magnitude and spectrum of abnormal ocular findings other than retinopathy of prematurity (ROP) detected during an ROP telescreening programme.

Methods: Retrospective review of the records of all premature babies screened for ROP from August 2015 to December 2019.

Results: A total 9105 babies were screened during the study period with total 17,075 imaging sessions. Read More

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Prolonged cetuximab treatment promotes p27-mediated G1 arrest and autophagy in head and neck squamous cell carcinoma.

Sci Rep 2021 Mar 4;11(1):5259. Epub 2021 Mar 4.

Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.

Cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is an efficient anti-tumor therapeutic agent that inhibits the activation of EGFR; however, data related to the cellular effects of prolonged cetuximab treatment are limited. In this study, the long-term cellular outcome of prolonged cetuximab treatment and the related molecular mechanism were explored in a head and neck squamous cell carcinoma cell line constitutively expressing a fluorescent ubiquitination-based cell cycle indicator. Fluorescent time-lapse imaging was used to assess clonal growth, cell motility, and cell-cycle progression. Read More

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Response criteria for intraocular retinoblastoma: RB-RECIST.

Pediatr Blood Cancer 2021 May 23;68(5):e28964. Epub 2021 Feb 23.

The Vision Center at Children's Hospital Los Angeles, Los Angeles, California, USA.

Standardized guidelines for assessing tumor response to therapy are essential for designing and conducting clinical trials. The Response Evaluation Criteria In Solid Tumors (RECIST) provide radiological standards for assessment of solid tumors. However, no such guidelines exist for the evaluation of intraocular cancer, and ocular oncology clinical trials have largely relied on indirect measures of therapeutic response-such as progression-free survival-to evaluate the efficacy of treatment agents. Read More

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Ophthalmic Magnetic Resonance Imaging: Where Are We (Heading To)?

Curr Eye Res 2021 Feb 4:1-20. Epub 2021 Feb 4.

Department Life, Light & Matter, University Rostock, Rostock, Germany.

Magnetic resonance imaging of the eye and orbit (MReye) is a cross-domain research field, combining (bio)physics, (bio)engineering, physiology, data sciences and ophthalmology. A growing number of reports document technical innovations of MReye and promote their application in preclinical research and clinical science. Realizing the progress and promises, this review outlines current trends in MReye. Read More

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February 2021

Retinoblastoma: What the Neuroradiologist Needs to Know.

AJNR Am J Neuroradiol 2021 Jan 28. Epub 2021 Jan 28.

Ophthalmology (L.A.D.), Mayo Clinic, Rochester, Minnesota

Retinoblastoma is the most common primary intraocular tumor of childhood. Accurate diagnosis at an early stage is important to maximize patient survival, globe salvage, and visual acuity. Management of retinoblastoma is individualized based on the presenting clinical and imaging features of the tumor, and a multidisciplinary team is required to optimize patient outcomes. Read More

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January 2021

Chemoreduction with topotecan and vincristine: Quantifying tumor response in bilateral retinoblastoma patients.

Pediatr Blood Cancer 2021 Apr 28;68(4):e28882. Epub 2021 Jan 28.

Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee.

Background: Evaluate the efficacy of two courses of vincristine and topotecan (VT) neoadjuvant intravenous chemotherapy in reducing retinoblastoma tumor volumes.

Methods: Twenty-seven patients with previously untreated, bilateral advanced retinoblastoma who were enrolled on a prospective treatment protocol (NCT00186888). Patients underwent high-resolution ophthalmic imaging at diagnosis and were reimaged following treatment with two cycles of VT. Read More

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Orbital Pseudocellulitis: A Retinoblastoma-Associated Masquerade Syndrome.

Ocul Oncol Pathol 2020 Dec 8;6(6):430-437. Epub 2020 Oct 8.

Unit of Ophthalmology, Department of Medicine, Surgery and Neuroscience, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

Introduction: A masquerade syndrome is an atypical presentation of a neoplastic process that mimics an inflammatory condition. In this paper, we focus on orbital pseudocellulitis.

Case Series: Our case series includes 5 retinoblastoma patients with orbital pseudocellulitis at presentation. Read More

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December 2020

Clinical characteristics, treatment and prognosis of children with unilateral retinoblastoma and intracranial segment of Retrobulbar optic nerve invasion.

BMC Ophthalmol 2021 Jan 14;21(1):38. Epub 2021 Jan 14.

Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, No. 2, Xihuan South Road, Yizhuang Economic and Technological Development Zone, Beijing, 100176, China.

Background: To analyze the clinical characteristics, treatment and prognosis of children with unilateral retinoblastoma (RB) and intracranial segment of retrobulbar optic nerve invasion.

Methods: A total of 14 children with unilateral RB and intracranial segment of retrobulbar optic nerve invasion were enrolled in this retrospective study from January 2009 to December 2018. Clinical characteristics, treatment and prognosis were collected and analyzed. Read More

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January 2021

Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion.

BMC Cancer 2021 Jan 11;21(1):53. Epub 2021 Jan 11.

Institute of Neurobiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.

Background: Prognosis for pediatric metastatic Retinoblastoma (Rb) is poor and current therapies are limited by high systemic toxicity rates and insufficient therapeutic efficacy for metastatic Rb. Tumor dissemination to the brain is promoted by the heterogeneous adhesive and invasive properties of Rb cells within the tumor. In this study we evaluate, for the first time, the expression, and roles of the ELTD1 and GPR125 adhesion G protein-coupled receptors (GPCRs) in Rb cell migration, viability and invasion. Read More

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January 2021

Correlation of Technical and Adjunctive Factors with Quantitative Tumor Reduction in Children Undergoing Selective Ophthalmic Artery Infusion Chemotherapy for Retinoblastoma.

AJNR Am J Neuroradiol 2021 01 24;42(2):354-361. Epub 2020 Dec 24.

Ophthalmology (Z.M.C.).

Background And Purpose: Selective ophthalmic artery infusion chemotherapy has improved ocular outcomes in children with retinoblastoma. Our aim was to correlate quantitative tumor reduction and dichotomous therapeutic response with technical and adjunctive factors during selective ophthalmic artery infusion chemotherapy for retinoblastoma. An understanding of such factors may improve therapeutic efficacy. Read More

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January 2021

Coexistent Retinoblastoma and Retinopathy of Prematurity in a Preterm Infant.

Ophthalmic Surg Lasers Imaging Retina 2020 Dec;51(12):732

[Ophthalmic Surg Lasers Imaging Retina. 2020;51:732.]. Read More

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December 2020

MR Imaging Features to Differentiate Retinoblastoma from Coats' Disease and Persistent Fetal Vasculature.

Cancers (Basel) 2020 Nov 30;12(12). Epub 2020 Nov 30.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081HV Amsterdam, The Netherlands.

Retinoblastoma mimickers, or pseudoretinoblastoma, are conditions that show similarities with the pediatric cancer retinoblastoma. However, false-positive retinoblastoma diagnosis can cause mistreatment, while false-negative diagnosis can cause life-threatening treatment delay. The purpose of this study is to identify the MR imaging features that best differentiate between retinoblastoma and the most common pseudoretinoblastoma diagnoses: Coats' disease and persistent fetal vasculature (PFV). Read More

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November 2020

Imaging Cellular Aerobic Glycolysis using Carbon Dots for Early Warning of Tumorigenesis.

Adv Mater 2021 Jan 27;33(1):e2005096. Epub 2020 Nov 27.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.

Early warning of tumor formation is crucial for the classification, treatment, and prognosis of tumor patients. Here, a new strategy is reported, aimed at realizing this goal based on imaging aerobic glycolysis processes using nitrogen-doped carbon dots (N-CDs) as fluorescent probes. The intensity of the photoluminescence emitted by the N-CDs is specifically enhanced by nicotinamide adenine dinucleotide (NAD , oxidized) in the physiological environment. Read More

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January 2021

Radiation dose reduction during intra-arterial chemotherapy for retinoblastoma: a retrospective analysis of 96 consecutive pediatric interventions using five distinct protocols.

Pediatr Radiol 2021 Apr 24;51(4):649-657. Epub 2020 Nov 24.

Section of Neurointerventional Radiology, Department of Radiology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Background: Intra-arterial chemotherapy (IAC) represents a mainstay of retinoblastoma treatment in children. Patients with retinoblastoma are uniquely at risk for secondary malignancies and are sensitive to the ionizing effects of radiation.

Objective: To retrospectively review a single institution's experience with IAC for retinoblastoma and the effect of variable intra-procedural imaging techniques on radiation exposure. Read More

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Different Types of Clinical Presentations and Stages of Retinoblastoma Among Children.

Cureus 2020 Sep 26;12(9):e10672. Epub 2020 Sep 26.

Internal Medicine, Creighton University, Omaha, USA.

Introduction Retinoblastoma (Rb) is the most common intraocular malignant tumor of childhood. The different modes of Rb presentation comprise proptosis, anterior chamber inflammatory signs, spontaneous hyphema, secondary glaucoma, and strabismus. The primary aim of this study was to investigate the different clinical presentations and stages of Rb that may help in early detection and timely diagnosis to prevent the advancement of the disease and increase rates of survival in children. Read More

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September 2020

Penetration of Carbon Nanotubes into the Retinoblastoma Tumor after Intravitreal Injection in LH T Transgenic Mice Reti-noblastoma Model.

J Ophthalmic Vis Res 2020 Oct-Dec;15(4):446-452. Epub 2020 Oct 25.

Electrical Engineering and Computer Science, University of Michigan Ann Arbor, MI, USA.

Purpose: To evaluate the penetration of carbon nanotubes (CNTs) throughout retinoblastoma in a transgenic mice model.

Methods: CNTs functionalized with fluorescein isothiocyanate and targeting ligands biotin (CTN-FITC-Bio, 0.5mg/ml), or folic acid (CNT-FITC-FA, 0. Read More

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October 2020

Case Report: Adult Retinoblastoma Progression in 19 Months.

Optom Vis Sci 2020 Nov;97(11):1010-1016

School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

Significance: Retinoblastoma is the most common intraocular malignancy in childhood, comprising 4% of all pediatric cancers. Adult onset is extremely rare. Enucleation is usually performed in adult cases because of the atypical presentations and malignant features of the tumor, which lead to misdiagnosis. Read More

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November 2020

Clinical Features and Survival of Chinese Children With Trilateral Retinoblastoma During 2006-2019: A Retrospective Multicenter Study.

Am J Ophthalmol 2021 03 10;223:184-192. Epub 2020 Oct 10.

Pediatric Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address:

Purpose: To summarize the clinical features and survival of Chinese patients with trilateral retinoblastoma (TRb), which may help guide early diagnosis and more effective treatments.

Design: Retrospective case series.

Methods: Clinical records of patients with TRb were reviewed to identify clinical characteristics and outcomes. Read More

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Long-Term Clinical Results and Management following Vitrectomy in Undetected Retinoblastoma Eyes.

Ocul Oncol Pathol 2020 Aug 25;6(4):244-250. Epub 2020 Feb 25.

Department of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Introduction: Given the rarity of retinoblastoma and the consequences of accidental vitrectomy in the event of misdiagnosis, reporting on clinical experience in this area is important.

Objective: The aim of this study was to analyse the management and complications with a focus on local orbital recurrence and metastatic disease in 10 children vitrectomized in an undetected retinoblastoma eye.

Methods: This is a retrospective descriptive case series conducted in a single-centre referral university hospital. Read More

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Histopathological assessment of optic nerve invasion guided by radiological findings in enucleated globes with retinoblastoma.

BMC Ophthalmol 2020 Sep 29;20(1):386. Epub 2020 Sep 29.

Pathology and Laboratory Medicine Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Background: Optic nerve (ON) invasion is an important high-risk feature, and an indicator for neoadjuvant chemotherapy and prognosis. We aim through this study to correlate the detected-ON invasion by Magnetic resonance imaging (MRI) with the corresponding confirmed histopathological level of invasion.

Methods: A retrospective study of enucleated globes with the diagnosis of retinoblastoma received in the histopathology department(s) from January 2015 to December 2016 (2 years). Read More

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September 2020

Epidemiological profile of retinoblastoma in North India: Implications for primary care and family physicians.

J Family Med Prim Care 2020 Jun 30;9(6):2843-2848. Epub 2020 Jun 30.

Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Retinoblastoma is the most common primary intraocular malignancy among children. Despite being curable in early stages, majority of the cases in India present in late stages, when outcomes are very poor.

Objectives: The aim of this study was to assess the epidemiological profile, clinical characteristics, and treatment practices among retinoblastoma patients in north India. Read More

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