981 results match your criteria Retinoblastoma Imaging


LincRNA-ROR is activated by H3K27 acetylation and induces EMT in retinoblastoma by acting as a sponge of miR-32 to activate the Notch signaling pathway.

Cancer Gene Ther 2020 May 22. Epub 2020 May 22.

Department of Obstetrics and Gynecology, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, China.

Recent studies have suggested that lincRNA-ROR is involved in the tumorigenesis of different types of cancers. However, the role of lincRNA-ROR in retinoblastoma has not been determined. We investigated lincRNA-ROR levels in 58 retinoblastoma and adjacent non-tumor tissues by quantitative reverse transcription PCR. Read More

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http://dx.doi.org/10.1038/s41417-020-0181-zDOI Listing

Whole-body magnetic resonance imaging as surveillance for subsequent malignancies in preadolescent, adolescent, and young adult survivors of germline retinoblastoma: An update.

Pediatr Blood Cancer 2020 Jul 9;67(7):e28389. Epub 2020 May 9.

Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Germline retinoblastoma (Rb) survivors are at lifelong risk for developing subsequent malignancies (SMNs). Optimal surveillance modalities are needed to detect SMN at an early stage in this high-risk cohort. We investigated the use of rapid whole-body magnetic resonance imaging (WB-MRI) as a noninvasive screening modality in this cohort. Read More

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http://dx.doi.org/10.1002/pbc.28389DOI Listing

A 20-year audit of retinoblastoma treatment outcomes.

Eye (Lond) 2020 May 6. Epub 2020 May 6.

Şanlıurfa Balıklıgöl State Hospital, Şanlıurfa, Turkey.

Objectives: To evaluate the long-term treatment outcomes in intraocular retinoblastoma (RB) including the associated factors for eventual treatment with external beam radiotherapy (EBRT) and enucleation as well as to analyse the risk factors for metastasis and death in extraocular RB.

Methods: Retrospective analysis of 390 eyes from 256 (89.8%) intraocular RB and 29 (10. Read More

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http://dx.doi.org/10.1038/s41433-020-0898-9DOI Listing

[Congenital Retinal Dystrophies: Combining Ophthalmological Techniques to Improve the Read-out].

Klin Monbl Augenheilkd 2020 Mar 17;237(3):275-287. Epub 2020 Mar 17.

Zentrum für seltene Netzhauterkrankungen, AugenZentrum Siegburg, MVZ Augenärztliches Diagnostik- und Therapiecentrum Siegburg GmbH.

An early diagnosis, differential diagnosis and possible decision about therapeutic interventions has considerable consequences for the personal and social life of patients affected with inherited retinal dystrophies (IRD). For the ophthalmologist, the clinical heterogeneity interferes with a simple diagnostic approach. The present review suggests a structured clinical approach for the ophthalmological diagnosis of IRD and discusses the relevance of different methods for diagnosis, differential diagnosis and the evaluation of progression. Read More

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http://dx.doi.org/10.1055/a-1118-3705DOI Listing

The anterior eye chamber: entry of the natural excretion pathway of gadolinium contrast agents?

Eur Radiol 2020 Mar 16. Epub 2020 Mar 16.

Department of Radiology, University Clinic Essen, Essen, Germany.

Objective: Previous studies provided evidence that gadolinium can be found in the aqueous chamber (AC) of the eye several hours post injection (p.i.) of gadolinium-based contrast agents (GBCAs). Read More

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http://dx.doi.org/10.1007/s00330-020-06762-4DOI Listing

Screening for Pineal Trilateral Retinoblastoma Revisited: A Meta-analysis.

Ophthalmology 2020 May 9;127(5):601-607. Epub 2019 Nov 9.

Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Topic: To determine the age up to which children are at risk of trilateral retinoblastoma (TRb) developing, whether its onset is linked to the age at which intraocular retinoblastomas develop, and the lead time from a detectable pineal TRb to symptoms.

Clinical Relevance: Approximately 45% of patients with retinoblastoma-those with a germline RB1 pathogenic variant-are at risk of pineal TRb developing. Early detection and treatment are essential for survival. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.10.040DOI Listing

Multimodal Imaging and Histopathological Evaluation of Berger's Space.

Ocul Oncol Pathol 2020 Jan 14;6(1):3-9. Epub 2019 May 14.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

Objective: To demonstrate the multimodal imaging and histopathology of Berger's space.

Methods: We conducted a retrospective in vivo analysis of 4 patients demonstrating Berger's space with intraocular pathological conditions, documented by slit-lamp biomicroscopic photography and, in 2 patients, also by optical coherence tomography (OCT). Additionally, we carried out a retrospective histological study of 7 enucleated eyes with retinoblastoma demonstrating Berger's space. Read More

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http://dx.doi.org/10.1159/000495724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984151PMC
January 2020

Magnetic Resonance Imaging Screening for Trilateral Retinoblastoma: The Memorial Sloan Kettering Cancer Center Experience 2006-2016.

Ophthalmol Retina 2020 Mar 31;4(3):327-335. Epub 2019 Oct 31.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Ophthalmology, Weill Cornell Medical School, New York, New York.

Purpose: Magnetic resonance imaging (MRI) has been used for baseline brain imaging and afterward as a screening tool for trilateral retinoblastoma (TRB), but there is no consensus on timing or frequency of screening worldwide. In this study, a cohort of hereditary retinoblastoma patients at increased risk for TRB was identified and the usefulness of aggressive neuroimaging was examined.

Design: Retrospective review of the medical records and MRI reports of patients with retinoblastoma treated at Memorial Sloan Kettering Cancer Center between January 1, 2006, and December 31, 2016. Read More

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http://dx.doi.org/10.1016/j.oret.2019.10.010DOI Listing

Multifunctional Nanoparticles for Multimodal Imaging-Guided Low-Intensity Focused Ultrasound/Immunosynergistic Retinoblastoma Therapy.

ACS Appl Mater Interfaces 2020 Feb 27;12(5):5642-5657. Epub 2020 Jan 27.

Department of Ophthalmology , The Second Affiliated Hospital of Chongqing Medical University , Chongqing 400010 , P. R. China.

Retinoblastoma (RB) is prone to delayed diagnosis or treatment and has an increased likelihood of metastasizing. Thus, it is crucial to perform an effective imaging examination and provide optimal treatment of RB to prevent metastasis. Nanoparticles that support diagnostic imaging and targeted therapy are expected to noninvasively integrate tumor diagnosis and treatment. Read More

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http://dx.doi.org/10.1021/acsami.9b22072DOI Listing
February 2020

Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA.

Ophthalmic Surg Lasers Imaging Retina 2019 12;51(1):43-49

Background And Objective: To describe the microvascular features of treated, clinically regressed, or reactivated retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system.

Patients And Methods: Single-center, prospective, cross-sectional, consecutive case-series of children with previously treated retinoblastoma who underwent portable OCTA of posterior retinoblastoma lesions.

Results: Eight tumors from seven eyes of five children with retinoblastoma were included. Read More

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http://dx.doi.org/10.3928/23258160-20191211-06DOI Listing
December 2019

Retinopathy in young retinoblastoma patients receiving a chemotherapy treatment: clinical trials and morphometric analysis.

Ophthalmic Genet 2019 12 10;40(6):521-533. Epub 2020 Jan 10.

Ocular Oncology Centre, Helmholtz National Medical Research Eye Disease Center, Moscow, Russian Federation.

: This research is to evaluate patients with retinoblastoma, who receive chemotherapy, with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) to compare the signs of retinopathy.: A prospective non-randomized trial included 125 eyes of 74 patients at the age of 24 ± 1.6 months with retinoblastoma. Read More

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http://dx.doi.org/10.1080/13816810.2019.1711427DOI Listing
December 2019

MCPIP1 overexpression in human neuroblastoma cell lines causes cell-cycle arrest by G1/S checkpoint block.

J Cell Biochem 2020 Jun 9;121(5-6):3406-3425. Epub 2020 Jan 9.

Laboratory of Molecular Genetics and Virology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Kraków, Poland.

Monocyte chemoattractant protein-1-induced protein 1 (MCPIP1) has a multidomain structure, which assures its pleiotropic activity. The physiological functions of this protein include repression of inflammatory processes and the prevention of immune disorders. The influence of MCPIP1 on the cell cycle of cancer cells has not been sufficiently elucidated. Read More

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http://dx.doi.org/10.1002/jcb.29614DOI Listing
June 2020
3.263 Impact Factor

The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.

Nat Commun 2020 01 7;11(1):24. Epub 2020 Jan 7.

Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892-4255, USA.

The spindle assembly checkpoint (SAC) prevents premature chromosome segregation by inactivating the anaphase promoting complex/cyclosome (APC/C) until all chromosomes are properly attached to mitotic spindles. Here we identify a role for Cullin-RING ubiquitin ligase complex 4 (CRL4), known for modulating DNA replication, as a crucial mitotic regulator that triggers the termination of the SAC and enables chromosome segregation. CRL4 is recruited to chromatin by the replication origin binding protein RepID/DCAF14/PHIP. Read More

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http://dx.doi.org/10.1038/s41467-019-13808-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946706PMC
January 2020

Multimodal imaging in pediatric arterial macroaneurysm: A case report.

Eur J Ophthalmol 2020 Jan 7:1120672119899033. Epub 2020 Jan 7.

Vita-Salute San Raffaele University, Milan, Italy.

Our aim is to report a case of asymptomatic retinal arterial macroaneurysm in a 9-year-old female patient. She was referred to our Ophthalmology clinic for a routine ophthalmologic examination and, after the detection of a juxtafoveal saccular vascular enlargement in indirect ophthalmoscopy, underwent a multimodal imaging assessment. Optical coherence tomography-angiography and fluorescein angiography were important to determine the nature of the lesion, identified as a congenital retinal arterial macroaneurysm. Read More

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http://dx.doi.org/10.1177/1120672119899033DOI Listing
January 2020

Craniofacial second primary tumors in patients with germline retinoblastoma previously treated with external beam radiotherapy: A retrospective institutional analysis.

Pediatr Blood Cancer 2020 Apr 6;67(4):e28158. Epub 2020 Jan 6.

Institut Curie, SIREDO Oncology Center (Care, Innovation and Research for children and AYA with Cancer), PSL Research University, Paris, France.

Background: The long-term survival of germline retinoblastoma patients is decreased due to the risk of second primary tumors (SPTs) that occur years after the diagnosis of retinoblastoma. This risk is related to genetic predisposition and other factors, such as the treatment of retinoblastoma by external beam radiotherapy (EBRT).

Procedure: We studied the incidence, risk factors, and prognosis of specific craniofacial SPTs developed within the margins of radiation field in a cohort of 209 patients with germline retinoblastoma treated with EBRT at our institution between 1977 and 2010. Read More

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http://dx.doi.org/10.1002/pbc.28158DOI Listing

Widefield imaging of retinal and choroidal tumors.

Int J Retina Vitreous 2019 12;5(Suppl 1):49. Epub 2019 Dec 12.

Department of Ophthalmology, Stanford University Byers Eye Institute, 2452 Watson Court MC 5353, Palo Alto, CA 94303 USA.

Background: Wide-field imaging plays an increasingly important role in ocular oncology clinics. The purpose of this review is to describe the commonly used wide-field imaging devices and review conditions seen in ocular oncology clinic that underwent wide-field imaging as part of the multimodal evaluation.

Summary Of Review: Wide-field or wide-angle imaging is defined as greater than 50° field of view. Read More

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http://dx.doi.org/10.1186/s40942-019-0196-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907111PMC
December 2019

Low retinal toxicity of intravitreal carboplatin associated with good retinal tumour control in transgenic murine retinoblastoma.

Clin Exp Ophthalmol 2019 Dec 24. Epub 2019 Dec 24.

Institut Curie, Research Center, PSL Research University, Chemistry, Modeling and Imaging for Biology (CMIB), University Centre, Orsay, France.

Background: Retinoblastoma is a rare intraocular malignancy in children. Current treatments have many adverse effects. New therapeutic approaches like intravitreal injections of chemotherapies are currently being developed but their toxicities need to be evaluated on animal models. Read More

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http://dx.doi.org/10.1111/ceo.13711DOI Listing
December 2019

Prediction of Core Signaling Pathway by Using Diffusion- and Perfusion-based MRI Radiomics and Next-generation Sequencing in Isocitrate Dehydrogenase Wild-type Glioblastoma.

Radiology 2020 Feb 17;294(2):388-397. Epub 2019 Dec 17.

From the Department of Radiology and Research Institute of Radiology (J.E.P., H.S.K., Y.J.), Department of Clinical Epidemiology and Biostatistics (S.Y.P.), Department of Pathology (S.J.N., S.M.C.), and Department of Neurosurgery (J.H.K.), University of Ulsan College of Medicine, Asan Medical Center, 43 Olympic-ro 88, Songpa-Gu, Seoul 05505, Korea.

Background Next-generation sequencing (NGS) enables highly sensitive cancer genomics analysis, but its clinical implications for therapeutic options from imaging-based prediction have been limited. Purpose To predict core signaling pathways in isocitrate dehydrogenase (IDH) wild-type glioblastoma by using diffusion and perfusion MRI radiomics and NGS. Materials and Methods The radiogenomics model was developed by using retrospective patients with glioma who underwent NGS and anatomic, diffusion-, and perfusion-weighted imaging between March 2017 and February 2019. Read More

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http://dx.doi.org/10.1148/radiol.2019190913DOI Listing
February 2020

Compound heterozygous novel frameshift variants in the gene result in Leber congenital amaurosis.

Cold Spring Harb Mol Case Stud 2019 12 13;5(6). Epub 2019 Dec 13.

Department of Ophthalmology, Columbia University, New York, New York 10019, USA.

The () gene encodes an 865-amino acid glycoprotein that is expressed in retinoblastoma cell lines and in the adult retina. The protein is localized to photoreceptor outer segment disc membranes, where it plays a structural role, and in the retinal pigment epithelium (RPE), where it acts as a cytosolic protein that mediates autophagy. Mutations in are typically associated with cone-rod dystrophy 12 (OMIM#3612657), autosomal dominant retinal macular dystrophy 2 (OMIM#608051), autosomal recessive retinitis pigmentosa 41 (OMIM#612095), and Stargardt disease 4 (OMIM#603786). Read More

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http://dx.doi.org/10.1101/mcs.a004481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913139PMC
December 2019

Accuracy of preoperative imaging in predicting optic nerve invasion in retinoblastoma: A retrospective study.

Indian J Ophthalmol 2019 12;67(12):2019-2022

Department of Orbit and Oculoplasty, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Purpose: Optic nerve invasion is an important cause of mortality in retinoblastoma. We aimed correlate preoperative imaging and surgical histopathology findings in enucleated eyes with retinoblastoma to determine the efficacy of preoperative imaging in predicting optic nerve invasion in retinoblastoma.

Methods: A retrospective review of records of all patients undergoing primary enucleation for retinoblastoma at a tertiary eyecare system between March 2013 and December 2017 with all patients having undergone preoperative imaging, either CT scan or MRI. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1611_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896533PMC
December 2019

Swept-source optical coherence tomography features of regressed macular retinoblastoma.

Indian J Ophthalmol 2019 12;67(12):2013-2018

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To describe the swept-source optical coherence tomography (SS-OCT) features of regressed macular retinoblastoma (RB).

Methods: A cross-sectional observational study was carried out in 13 patients with regressed macular RB with good fixation in at least one eye. Fundus photography and SS-OCT were documented. Read More

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http://dx.doi.org/10.4103/ijo.IJO_533_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896562PMC
December 2019
0.927 Impact Factor

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.

Genes Dev 2019 12 14;33(23-24):1718-1738. Epub 2019 Nov 14.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

More than 90% of small cell lung cancers (SCLCs) harbor loss-of-function mutations in the tumor suppressor gene The canonical function of the gene product, pRB, is to repress the E2F transcription factor family, but pRB also functions to regulate cellular differentiation in part through its binding to the histone demethylase KDM5A (also known as RBP2 or JARID1A). We show that KDM5A promotes SCLC proliferation and SCLC's neuroendocrine differentiation phenotype in part by sustaining expression of the neuroendocrine transcription factor ASCL1. Mechanistically, we found that KDM5A sustains ASCL1 levels and neuroendocrine differentiation by repressing NOTCH2 and NOTCH target genes. Read More

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http://dx.doi.org/10.1101/gad.328336.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942053PMC
December 2019
10.798 Impact Factor

Diagnosis of Postlaminar Optic Nerve Invasion in Retinoblastoma With MRI Features.

J Magn Reson Imaging 2020 Apr 16;51(4):1045-1052. Epub 2019 Oct 16.

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Retinoblastomas (RBs) with postlaminar optic nerve invasion (PLONI) increases the risk of local recurrence or systemic metastasis. Most MRI studies on PLONI focused on optic nerve enhancement and tumor size, with reported relatively high specificity (84-98%) but low sensitivity (37-78%), which shows room for improvement, especially with regard to sensitivity.

Purpose: To evaluate the diagnostic performance for detecting PLONI with RB using MRI features. Read More

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http://dx.doi.org/10.1002/jmri.26961DOI Listing

Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.

Proc Natl Acad Sci U S A 2019 10 14;116(44):22300-22306. Epub 2019 Oct 14.

Molecular Oncology Unit, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), 28040 Madrid, Spain;

High-grade neuroendocrine lung malignancies (large-cell neuroendocrine cell carcinoma, LCNEC, and small-cell lung carcinoma, SCLC) are among the most deadly lung cancer conditions with no optimal clinical management. The biological relationships between SCLC and LCNEC are still largely unknown and a current matter of debate as growing molecular data reveal high heterogeneity with potential therapeutic consequences. Here we describe murine models of high-grade neuroendocrine lung carcinomas generated by the loss of 4 tumor suppressors. Read More

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http://dx.doi.org/10.1073/pnas.1821745116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825275PMC
October 2019
1 Read
9.809 Impact Factor

Updates in imaging in ocular oncology.

F1000Res 2019 1;8. Epub 2019 Oct 1.

Ophthalmology, Stanford Byers Eye Institute, Palo Alto, CA, 94303, USA.

Innovations in ophthalmic imaging have made a profound impact on the diagnosis and treatment of ophthalmic disease. In ocular oncology, the development of optical coherence tomography with enhanced depth imaging and swept source technologies has made it possible to visualize the anatomical characteristics of retinoblastoma and uveal melanoma with a level of detail previously unobtainable on clinical exam alone. As a result, our understanding of the pathophysiology of vision loss in choroidal melanoma in particular has improved. Read More

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http://dx.doi.org/10.12688/f1000research.19979.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774056PMC
October 2019
1 Read

Management of advanced uni- or bilateral retinoblastoma with macroscopic optic nerve invasion.

Pediatr Blood Cancer 2020 01 1;67(1):e27998. Epub 2019 Oct 1.

Oncology Center SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.

Background: Retinoblastoma with macroscopic optic nerve (ON) invasion depicted by imaging at diagnosis remains a major problem and carries a poor prognosis. We sought to describe the treatment and outcome of these high-risk patients.

Methods: Retrospective mono-institutional clinical, radiological, and histological review of patients with uni- or bilateral retinoblastoma with obvious ON invasion, defined by radiological optic nerve enlargement (RONE) depicted by computed tomography scan or magnetic resonance imaging (MRI), was performed. Read More

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http://dx.doi.org/10.1002/pbc.27998DOI Listing
January 2020
1 Read

Secondary Prevention of Retinoblastoma Revisited: Laser Photocoagulation of Invisible New Retinoblastoma.

Ophthalmology 2020 01 21;127(1):122-127. Epub 2019 Aug 21.

Department of Ophthalmology and Vision Sciences, Hospital for Sick Children, Toronto, Canada; Department of Ophthalmology & Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Departments of Molecular Genetics and Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Visual Sciences, Toronto Western Research Institute, Toronto, Ontario, Canada.

Purpose: Invisible retinoblastoma tumors are now detected with screening for retinal tumors in at-risk neonates (those inheriting RB1 pathogenic alleles from affected parents) using handheld OCT. Laser photocoagulation is challenging, requiring exact localization of a tumor invisible to indirect ophthalmoscopy and standard imaging. We describe OCT-guided localization and photocoagulation of these invisible tumors with 1-year follow-up. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.08.011DOI Listing
January 2020
6 Reads

Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition.

Proc Natl Acad Sci U S A 2019 10 16;116(40):20104-20114. Epub 2019 Sep 16.

Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15213;

Viral cancers show oncogene addiction to viral oncoproteins, which are required for survival and proliferation of the dedifferentiated cancer cell. Human Merkel cell carcinomas (MCCs) that harbor a clonally integrated Merkel cell polyomavirus (MCV) genome have low mutation burden and require viral T antigen expression for tumor growth. Here, we showed that MCV MCC cells cocultured with keratinocytes undergo neuron-like differentiation with neurite outgrowth, secretory vesicle accumulation, and the generation of sodium-dependent action potentials, hallmarks of a neuronal cell lineage. Read More

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http://dx.doi.org/10.1073/pnas.1907154116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778204PMC
October 2019
2 Reads

Optical coherence tomography (OCT) to image active and inactive retinoblastomas as well as retinomas.

Acta Ophthalmol 2020 Mar 26;98(2):158-165. Epub 2019 Aug 26.

Department of Ophthalmology, Amsterdam UMC, location VUMC, HV Amsterdam, The Netherlands.

Purpose: To illustrate Optical Coherence Tomography (OCT) images of active and inactive retinoblastoma (Rb) tumours.

Methods: Current observational study included patients diagnosed with retinoblastoma and retinoma who were presented at Amsterdam UMC and Jules-Gonin Eye Hospital, between November 2010 and October 2017. Patients aged between 0 and 4 years were imaged under general anaesthesia with handheld OCT in supine position. Read More

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http://dx.doi.org/10.1111/aos.14214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078953PMC
March 2020
3 Reads

Synthesis and Biological Evaluation of Novel Tc-Labeled Palbociclib Derivatives Targeting Cyclin-Dependent Kinase 4/6 (CDK4/6) as Potential Cancer Imaging Agents.

Mol Pharm 2019 10 26;16(10):4213-4222. Epub 2019 Aug 26.

Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry , Beijing Normal University , Beijing 100875 , P. R. China.

Cancer results from cell proliferation that exceeds normal growth control. There are various specific proteins that control and regulate the cell cycle, such as cyclin-dependent kinases (CDKs), cyclins, and retinoblastoma protein (pRb). The aberration of the cyclin D-CDK4/6-INK4-pRb pathway occurs frequently in cancers; thus, CDK4/6 is an attractive target for the development of radiopharmaceuticals for tumor imaging. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00540DOI Listing
October 2019
3 Reads

Tumour size criteria for Group D and E eyes in the International Classification System for Retinoblastoma: effects on rates of globe salvage and high-risk histopathologic features.

Acta Ophthalmol 2020 Feb 17;98(1):e121-e125. Epub 2019 Aug 17.

The Vision Center at Children's Hospital Los Angeles, Los Angeles, California, USA.

Purpose: To determine the significance of large tumour size as a criteria for classifying advanced intraocular retinoblastoma, analysing rates of globe survival and high-risk (HE) histopathologic features.

Methods: Retrospective chart review of 212 eyes diagnosed with Group D (111 eyes) or Group E (101 eyes) retinoblastoma in at least one eye from January 1, 2006 to December 31, 2016 using the Los Angeles (LA) Classification System (no tumour size criteria for Group E). The 111 Group D tumours were then reclassified to Group E using 10, 12, 14, 16, 18 mm tumour size criteria, as determined by ultrasound or magnetic resonance imaging dimensions. Read More

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http://dx.doi.org/10.1111/aos.14222DOI Listing
February 2020
3 Reads

Tumor pharmacokinetics and pharmacodynamics of the CDK4/6 inhibitor ribociclib in patients with recurrent glioblastoma.

J Neurooncol 2019 Sep 9;144(3):563-572. Epub 2019 Aug 9.

Department of Neurology, Division of Neuro-Oncology, University of Virginia Health System, P.O. Box 800432, Charlottesville, VA, 22908, USA.

Introduction: We conducted a phase Ib study (NCT02345824) to determine whether ribociclib, an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), penetrates tumor tissue and modulates downstream signaling pathways including retinoblastoma protein (Rb) in patients with recurrent glioblastoma (GBM).

Methods: Study participants received ribociclib (600 mg QD) for 8-21 days before surgical resection of their recurrent GBM. Total and unbound concentrations of ribociclib were measured in samples of tumor tissue, plasma, and cerebrospinal fluid (CSF). Read More

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http://link.springer.com/10.1007/s11060-019-03258-0
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http://dx.doi.org/10.1007/s11060-019-03258-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863163PMC
September 2019
4 Reads

Intra-arterial chemotherapy for retinoblastoma: the dosimetric impact.

Neuroradiology 2019 Sep 22;61(9):1083-1091. Epub 2019 Jul 22.

Unit of Neuroimaging and Neurointervention, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

Purpose: Purposes are (1) to measure main radiation parameters and (2) to propose a method to estimate the absorbed doses of internal organs starting from DAP values. Measuring the exposition of internal organs by repeated irradiations on an anthropomorphic phantom with the same settings used in vivo, we could establish correlations between (1) DAP and the dose recorded by a dosimeter placed along the X-ray beam entrance pathway; (2) the dose recorded by the same dosimeter and the absorbed dose in internal organs.

Methods: Forty-four consecutive patients (16 males, 28 females) (mean age 35. Read More

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http://dx.doi.org/10.1007/s00234-019-02260-7DOI Listing
September 2019
8 Reads
2.485 Impact Factor

Evaluation of the antileukemic effects of neurokinin-1 receptor antagonists, aprepitant, and L-733,060, in chronic and acute myeloid leukemic cells.

Anticancer Drugs 2019 08;30(7):e0769

Pharmaceutical Microbiology, Faculty of Pharmacy.

Neurokinin-1 receptor (NK1R) antagonists are known for their anxiolytic, antiemetic, anticancer, and anti-inflammatory effects. Aprepitant is used in vomiting and nausea, which are the most common side-effects of patients undergoing chemotherapy for cancer. L-733,060 has been shown to have anxiolytic and antidepressant effects in animal studies and anticancer effect in in-vitro studies. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000769DOI Listing
August 2019
5 Reads

Asteroid Hyalosis Simulating Vitreous Seeds in a Patient With Retinoblastoma.

J Pediatr Ophthalmol Strabismus 2019 Jul 5;56:e41-e44. Epub 2019 Jul 5.

A patient treated for retinoblastoma developed vitreous floaters 15 years later and was referred for recurrence with vitreous seeding. Clinical examination demonstrated a regressed scar and numerous calcified vitreous opacities with a "clear zone" on ultrasonography. The final diagnosis was asteroid hyalosis in an eye with regressed retinoblastoma. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01913913-2019
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http://dx.doi.org/10.3928/01913913-20190515-01DOI Listing
July 2019
6 Reads

Technical and anatomical factors affecting intra-arterial chemotherapy fluoroscopy time and radiation dose for intraocular retinoblastoma.

J Neurointerv Surg 2019 Dec 13;11(12):1273-1276. Epub 2019 Jun 13.

Diagnostic and Interventional Radiology, Baylor College of Medicine, Houston, Texas, USA.

Background: Intra-arterial chemotherapy has an increasingly prominent role in the management of retinoblastoma. One concern regarding this technique is procedural radiation exposure.

Objectives: To examine the effects of our institution's procedural technique on fluoroscopy parameters for patients undergoing intra-arterial chemotherapy infusions for intraocular retinoblastoma. Read More

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http://dx.doi.org/10.1136/neurintsurg-2019-014910DOI Listing
December 2019
5 Reads

Contemporary management of retinoblastoma in the context of a low-resource country.

Niger Postgrad Med J 2019 Apr-Jun;26(2):69-79

Retinoblastoma Unit, Royal London Hospital, Barts Health NHS Trust; Department of Paediatrics, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Retinoblastoma (RB) is the most common ocular cancer, and it typically presents before the age of 5 years in over 90% of cases. In high resource countries, RB patients tend to survive and retain their sight. This is not the case in low-resource countries because of late presentation and delayed intervention arising mostly from sociocultural and socioeconomic challenges. Read More

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http://dx.doi.org/10.4103/npmj.npmj_21_19DOI Listing
June 2019
18 Reads

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity".

Prog Retin Eye Res 2019 11 5;73:100764. Epub 2019 Jun 5.

Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Lausanne, Switzerland.

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by the first eye salvage attempts with radiotherapy. This led to the empiric delineation of a window for conservative management subject to a "state of metastatic grace" never to be violated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13509462183007
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http://dx.doi.org/10.1016/j.preteyeres.2019.05.005DOI Listing
November 2019
14 Reads

Smartphone-Based, Rapid, Wide-Field Fundus Photography for Diagnosis of Pediatric Retinal Diseases.

Transl Vis Sci Technol 2019 May 30;8(3):29. Epub 2019 May 30.

University of Michigan, Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA.

Purpose: An important, unmet clinical need is for cost-effective, reliable, easy-to-use, and portable retinal photography to evaluate preventable causes of vision loss in children. This study presents the feasibility of a novel smartphone-based retinal imaging device tailored to imaging the pediatric fundus.

Methods: Several modifications for children were made to our previous device, including a child-friendly 3D printed housing of animals, attention-grabbing targets, enhanced image stitching, and video-recording capabilities. Read More

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http://dx.doi.org/10.1167/tvst.8.3.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543857PMC
May 2019
10 Reads

Unusual ophthalmic artery origin: Implications for intraarterial chemotherapy of retinoblastoma.

Interv Neuroradiol 2019 Dec 3;25(6):638-643. Epub 2019 Jun 3.

Department of Radiology, Hacettepe University Faculty of Medicine, Sıhhiye, Ankara, Turkey.

We report two pediatric retinoblastoma patients with unusual ophthalmic artery (OA) origins who were referred to our interventional neuroradiology department for intraarterial chemotherapy. The first patient had double OAs arising from the ipsilateral internal carotid artery and a central retinal artery (CRA) arising from the more cranially located artery, whereas the second patient had an OA originating from the A1 segment of the ipsilateral anterior cerebral artery. In both cases the CRA arose from the artery entering the orbit through the optic foramen. Read More

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http://dx.doi.org/10.1177/1591019919852737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838853PMC
December 2019
2 Reads

Phase-based OCT angiography in diagnostic imaging of pediatric retinoblastoma patients: abnormal blood vessels in post-treatment regression patterns.

Biomed Opt Express 2019 May 3;10(5):2213-2226. Epub 2019 Apr 3.

Department of Physics and Astronomy, VU University, De Boelelaan 1081, Amsterdam, 1081 HV, The Netherlands.

Phase-based OCT angiography of retinoblastoma regression patterns with a novel handheld 1050 nm clinical imaging system is demonstrated for the first time in children between 0 and 4 years old under general anesthesia. Angiography is mapped at OCT resolution by flow detection at every pixel with en-face projection from the volume between nerve fiber layer and retinal pigment epithelium. We show a striking difference between blood vasculature of healthy retina, and retinoblastoma regression patterns after chemotherapy, as well as varying complexity of abnormal vasculature in regression patterns types 2, 3, and 4. Read More

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http://dx.doi.org/10.1364/BOE.10.002213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524593PMC
May 2019
6 Reads

In-utero ultrasonography detection of fetal retinoblastoma and neonatal selective ophthalmic artery chemotherapy.

Indian J Ophthalmol 2019 06;67(6):958-960

Dongguan Women and Children Hospital, Dongguan, Guangdong, China.

We report a case of non-familial, sporadic fetal retinoblastoma (RB) that was accidently detected at 39 weeks of gestation on pre-natal ultrasonography in left eye (OS). Post-natal examination revealed Group A and, Group D RB in right eye (OD) and OS, respectively. At 35 days, selective ophthalmic artery intra-arterial chemotherapy (IAC) was performed in OS and laser for OD. Read More

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http://dx.doi.org/10.4103/ijo.IJO_340_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552617PMC
June 2019
6 Reads
0.927 Impact Factor

Persistent fetal vasculature feeding a retinoblastoma.

Indian J Ophthalmol 2019 06;67(6):951

Department of Ocular Oncology, Narayana Nethralaya, Bengaluru, Karnataka, India.

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http://dx.doi.org/10.4103/ijo.IJO_353_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552584PMC
June 2019
7 Reads

Commentary: Seeing the big picture: Panoramic smartphone fundus imaging sans accessories.

Indian J Ophthalmol 2019 06;67(6):949-950

Department of Ophthalmology, Jubilee Mission Medical College, Thrissur, Kerala, India.

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http://dx.doi.org/10.4103/ijo.IJO_727_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552597PMC
June 2019
1 Read

Unmodified iPhone XS Max for fundus montage imaging in cases of retinoblastoma.

Indian J Ophthalmol 2019 06;67(6):948-949

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, AIIMS, New Delhi, India.

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http://dx.doi.org/10.4103/ijo.IJO_2144_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552607PMC
June 2019
23 Reads
0.927 Impact Factor

Clinical characterization of icotinib-induced chemoresistance in erlotinib-treated lung adenocarcinoma patient with EGFR mutations: A case report.

Medicine (Baltimore) 2019 May;98(18):e15489

Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.

Rationale: Mounting evidences reveal that mutation of epidermal growth factor receptor (EGFR) may induce the resistance of tyrosine kinase inhibitors (TKIs). TKI-resistant lung cancer cells are sensitive to inhibition of the EGFR pathway. This case report aimed to characterize the therapeutic benefits of erlotinib, a targeted drug, on an advanced lung cancer patient with somatic EGFR mutation. Read More

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http://dx.doi.org/10.1097/MD.0000000000015489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504272PMC
May 2019
20 Reads

Exudative Retinal Detachment Following Intravitreal Chemotherapeutic Treatment for Retinoblastoma.

Ophthalmic Surg Lasers Imaging Retina 2019 04;50(4):248-252

A 35-month-old boy was diagnosed with retinoblastoma and underwent combination intra-arterial (IAC) and intravitreal chemotherapy. His course was complicated by anaphylactic reaction to IAC, yet he continued to improve with sustained intravitreal therapy. Eight months into treatment, the affected eye developed exudative retinal detachment, which resolved with sub-Tenon's steroid administration. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
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http://dx.doi.org/10.3928/23258160-20190401-09DOI Listing
April 2019
9 Reads

Clinical Predictors at Diagnosis of Low-Risk Histopathology in Unilateral Advanced Retinoblastoma.

Ophthalmology 2019 09 12;126(9):1306-1314. Epub 2019 Apr 12.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Canada; Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. Electronic address:

Purpose: Attempted eye salvage for unilateral (cT2b/group D) retinoblastoma may risk tumor spread compared with primary enucleation. Identification of clinical features predictive of low histopathologic risk support safe trial salvage.

Design: Retrospective, noncomparative single-institutional observational case series. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.04.003DOI Listing
September 2019
1 Read

Effectiveness of alternative routes of intra-arterial chemotherapy administration for retinoblastoma: Potential for response and complications.

Interv Neuroradiol 2019 Oct 31;25(5):556-561. Epub 2019 Mar 31.

Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

Objective: Intra-arterial chemotherapy (IAC) is now the first line treatment for selected patients with retinoblastoma (Rb). Typically, IAC is infused following the selective catheterization of the ophthalmic artery (OA) on the affected side. However, in some patients, the OA alone may not provide vascular supply to the tumor, whereas in other instances the efficacy of IAC could be compromised due to the presence of prominent collateral vessels from the external carotid artery (ECA). Read More

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http://dx.doi.org/10.1177/1591019919831953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777104PMC
October 2019
8 Reads