22,384 results match your criteria Retinoblastoma


Unusual presentation of Retinoblastoma.

Eur J Ophthalmol 2020 Jul 2:1120672120939388. Epub 2020 Jul 2.

Department of Radiodiagnosis, Government Medical College Hospital, Chandigarh, India.

Most cases of retinoblastoma are diagnosed before the age of 5 years. The cases in older age groups can have variable presentations leading to misdiagnosis and management challenges. We report a case of retinoblastoma in an 8-year-old female who was primarily referred as a case of sympathetic ophthalmia due to a co-incidental misleading history of penetrating eye injury to other eye 3 weeks prior. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672120939388DOI Listing

Comparison of efficacy and toxicity of intravitreal melphalan formulations for retinoblastoma.

PLoS One 2020 1;15(7):e0235016. Epub 2020 Jul 1.

Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, United States of America.

Objective: Intravitreal melphalan injections are commonly used in the treatment for intraocular retinoblastoma. This study compares retinal toxicity and ocular survival between two formulations, with and without propylene glycol (Alkeran vs. Evomela, respectively). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235016PLOS

Structure based design of inhibitory peptides targeting ornithine decarboxylase dimeric interface and validation in human retinoblastoma Y79 cells.

J Biomol Struct Dyn 2020 Jun 27:1-15. Epub 2020 Jun 27.

Centre for Bioinformatics, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, Chennai, India.

Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine. Elevated levels of polyamines are manifested proliferating cancer cells and are found to promote tumour cell adhesion. Di-flouro methyl orninthine is a known inhibitor of ODC, however its usage is limited due its low affinity quick clearance and incompetent cellular uptake, thus posing a need for potential inhibitors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2020.1785331DOI Listing

[Site-directed mutagenesis of long gene by partial amplification combining with double fragments ligation].

Sheng Wu Gong Cheng Xue Bao 2020 Jun;36(6):1232-1240

Medical College, Hubei University of Arts and Science, Xiangyang 441053, Hubei, China.

Overlap extension PCR is a common method for site-directed mutagenesis. As objective gene sequence growing longer, it is often difficult to obtain the target product in the second round of PCR, and it is highly possible to introduce unexpected mutations into a long gene fragment by PCR. To circumvent these problems, we can only amplify a small gene fragment which contain the target mutation by overlap extension PCR, and then ligate it with vector to get target plasmid. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13345/j.cjb.190476DOI Listing

A single-arm study of systemic and sub-Tenon chemotherapy for Groups C and D intraocular retinoblastoma: A Children's Oncology Group study (ARET 0231).

Pediatr Blood Cancer 2020 Jun 26:e28502. Epub 2020 Jun 26.

The Retinoblastoma Center of Houston, Houston, Texas.

Background: Eyes with Group D intraocular retinoblastoma have low salvage rates. A pilot study showed safety and efficacy of sub-Tenon's fascia carboplatin with systemic chemotherapy supporting further study.

Methods: Children with newly diagnosed bilateral intraocular retinoblastoma with at least one remaining Group C or D eye were treated with six courses of carboplatin/etoposide/vincristine (CEV) with sub-Tenon's fascia carboplatin for Group C/D eyes during courses 2-4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.28502DOI Listing

Smartphone wide-field fundus photography in retinoblastoma with a nasal endoscope.

Indian J Ophthalmol 2020 Jul;68(7):1255-1256

Oculoplasty and Ocular Oncology Services, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijo.IJO_1666_19DOI Listing

Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions.

AJNR Am J Neuroradiol 2020 Jun 25. Epub 2020 Jun 25.

From the Department of Neurosurgery (A.S., J.H.W., V.X., K.S., M.P.B., S.D., S.R., S.T., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania

Background And Purpose: Intra-arterial chemotherapy for retinoblastoma has dramatically altered the natural history of the disease. The remarkable outcomes associated with a high safety profile have pushed the envelope to offer treatment for patients weighing ≤10 kg. The purpose was to determine the efficacy and safety of IAC infusions performed in infants weighing ≤10 kg with intraocular retinoblastoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3174/ajnr.A6590DOI Listing

Cataract surgery in treated retinoblastoma eyes: A study of 29 eyes.

Eur J Ophthalmol 2020 Jun 25:1120672120938575. Epub 2020 Jun 25.

Child Sight Institute, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To study the outcomes of cataract surgery in treated retinoblastoma (RB) eyes.

Methods: Retrospective study of 29 eyes of 27 patients.

Results: Based on International Classification of Intraocular Retinoblastoma, tumors belonged to group B ( = 3, 10%), C ( = 1, 4%), D ( = 10, 34%), and E ( = 3, 10%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672120938575DOI Listing

Gene expression profiling of tumor stroma interactions in retinoblastoma.

Exp Eye Res 2020 Jun 22:108067. Epub 2020 Jun 22.

Larsen & Toubro Department of Ocular Pathology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Chennai, 600006, Tamil Nadu, India; School of Medicine, Centre for Molecular and Medical Research, Deakin University, Geelong, 3216, VIC, Australia. Electronic address:

We aimed to identify the critical molecular pathways altered upon tumor stroma interactions in retinoblastoma (RB). In vitro 2 D cocultures of RB tumor cells (Weri-Rb-1 and NCC-RbC-51) with primary bone marrow stromal cells (BMSC) was established. Global gene expression patterns in coculture samples were assessed using Affymetrix Prime view human gene chip microarray and followed with bioinformatics analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2020.108067DOI Listing

Comparison of the therapeutic effects of lobaplatin and carboplatin on retinoblastoma in vitro and in vivo.

Int J Oncol 2020 Jun 22. Epub 2020 Jun 22.

Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou, Guangdong 510627, P.R. China.

Retinoblastoma (RB) is one of the most aggressive malignancies affecting infants and children. Platinum drugs are commonly used in the treatment of RB; however, their efficacy is often compromised by drug resistance and severe toxicity. The present study aimed to investigate and compare the toxicity and antitumor activity of the third‑generation platinum drugs, carboplatin and lobaplatin, in vitro and in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijo.2020.5085DOI Listing

A conserved amino acid in the C-terminus of HPV E7 mediates binding to PTPN14 and repression of epithelial differentiation.

J Virol 2020 Jun 24. Epub 2020 Jun 24.

Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

The human papillomavirus (HPV) E7 oncoprotein is a primary driver of HPV-mediated carcinogenesis. The E7 proteins from diverse HPV bind to the host cellular non-receptor protein tyrosine phosphatase type 14 (PTPN14) and direct it for degradation through the activity of the E7-associated host E3 ubiquitin ligase UBR4. Herein we show that a highly conserved arginine residue in the C-terminal domain of diverse HPV E7 mediates interaction with PTPN14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01024-20DOI Listing

A Polyphenol-Rich Extract From Muscadine Grapes Inhibits Triple-Negative Breast Tumor Growth.

Integr Cancer Ther 2020 Jan-Dec;19:1534735420917444

Wake Forest School of Medicine, Winston-Salem, NC, USA.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that tends to affect young women and has a high propensity to metastasize. No targeted treatments are available for this type of breast cancer due to a lack of estrogen or progesterone receptors or overexpression of human epidermal growth factor receptor type 2 overexpression. Currently, patients have no therapeutic options once standard of care is complete, indicating a need for safe and effective therapies to slow or prevent the progression of TNBC to metastatic disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1534735420917444DOI Listing

Preimplantation genetic diagnosis for retinoblastoma survivors: a cost-effectiveness study.

Reprod Biomed Soc Online 2020 Jun 11;10:37-45. Epub 2020 May 11.

Eye Genetics Research Unit, The Children's Hospital at Westmead, Children's Medical Research Institute, Save Sight Institute, University of Sydney, Sydney, Australia.

This study aimed to investigate the cost-effectiveness of preimplantation genetic diagnosis (PGD) for the reproductive choices of patients with heritable retinoblastoma. The study modelled the costs of three cycles of in-vitro fertilization (IVF) and PGD across all uptake rates of PGD, number of children affected with retinoblastoma at each uptake rate and the estimated quality-adjusted life years (QALYs) gained. Cost-effectiveness analysis was conducted from the Australian public healthcare perspective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rbms.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301166PMC

Clinical relevance of B7H3 expression in retinoblastoma.

Sci Rep 2020 Jun 23;10(1):10185. Epub 2020 Jun 23.

L&T Ocular Pathology Department, Vision Research Foundation, Chennai, India.

Retinoblastoma (RB) is the most common paediatric intraocular tumour. Currently, chemotherapy is widely used to reduce the chance of metastasis as well as for vision salvage. The limitations of chemotherapy for RB include chemoresistance and cytotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-67101-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311428PMC

Pathways involved in viral oncogenesis: New perspectives from virus-host protein interactomics.

Biochim Biophys Acta Mol Basis Dis 2020 Jun 20;1866(10):165885. Epub 2020 Jun 20.

Department of Bioengineering, Marmara University, Istanbul, Turkey. Electronic address:

Oncogenic viruses are among the apparent causes of cancer-associated mortality. It was estimated that 12% to 15% of human malignancies are linked to oncoviruses. Although modernist strategies and traditional genetic studies have defined host-pathogen interactions of the oncoviruses, their host functions which are critical for the establishment of infection still remain mysterious. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2020.165885DOI Listing

The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence-associated epigenomic remodeling.

Aging Cell 2020 Jun 22. Epub 2020 Jun 22.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

Senescent cells may possess the intrinsic programs of metabolic and epigenomic remodeling, but the molecular mechanism remains to be clarified. Using an RNAi-based screen of chromatin regulators, we found that knockdown of the NSD2/WHSC1/MMSET methyltransferase induced cellular senescence that augmented mitochondrial mass and oxidative phosphorylation in primary human fibroblasts. Transcriptome analysis showed that loss of NSD2 downregulated the expression of cell cycle-related genes in a retinoblastoma protein (RB)-mediated manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.13173DOI Listing

Functional genomics identifies new synergistic therapies for retinoblastoma.

Oncogene 2020 Jun 22. Epub 2020 Jun 22.

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, Canada.

Local intravitreal or intra-arterial chemotherapy has improved therapeutic success for the pediatric cancer retinoblastoma (RB), but toxicity remains a major caveat. RB initiates primarily with RB1 loss or, rarely, MYCN amplification, but the critical downstream networks are incompletely understood. We set out to uncover perturbed molecular hubs, identify synergistic drug combinations to target these vulnerabilities, and expose and overcome drug resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-020-1372-7DOI Listing

Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2.

Proc Natl Acad Sci U S A 2020 Jun 22. Epub 2020 Jun 22.

Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet, SE-171 65, Stockholm, Sweden;

Stemness encompasses the capability of a cell for self-renewal and differentiation. The stem cell maintains a balance between proliferation, quiescence, and regeneration via interactions with the microenvironment. Previously, we showed that ectopic expression of the mitochondrial ribosomal protein S18-2 (MRPS18-2) led to immortalization of primary fibroblasts, accompanied by induction of an embryonic stem cell (ESC) phenotype. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1922535117DOI Listing

High levels of global genome methylation in patients with retinoblastoma.

Oncol Lett 2020 Jul 13;20(1):715-723. Epub 2020 May 13.

Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY 10032, USA.

Retinoblastoma is a tumor of the embryonic neural retina in young children. The DNA methyltransferase 1 () gene has been demonstrated to be transcriptionally activated in cells lacking retinoblastoma 1 (). Thus, there is a direct interaction between and . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2020.11613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286142PMC

Restriction point regulation at the crossroads between quiescence and cell proliferation.

FEBS Lett 2020 Jun 21. Epub 2020 Jun 21.

Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.

The coordination of cell proliferation with reversible cell cycle exit into quiescence is crucial for the development of multicellular organisms and for tissue homeostasis in the adult. The decision between quiescence and proliferation occurs at the restriction point, which is widely thought to be located in the G1 phase of the cell cycle, when cells integrate accumulated extracellular and intracellular signals to drive this binary cellular decision. On the molecular level, decision-making is exerted through the activation of cyclin-dependent kinases (CDKs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1873-3468.13867DOI Listing

Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/β-Catenin Axis.

Invest Ophthalmol Vis Sci 2020 Jun;61(6):41

,.

Purpose: The tumor-initiating function of long non-coding RNA (lncRNA), zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) was reported in lung cancer, yet the relevance of ZFPM2-AS1 in retinoblastoma (RB), a malignancy representing 2.5% to 4% incidence of cancers among children, has not been elucidated. Thus, we attempted to assess the effect of ZFPM2-AS1 and underlying mechanism in RB progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.61.6.41DOI Listing

Expression Changes and Impact of the Extracellular Matrix on Etoposide Resistant Human Retinoblastoma Cell Lines.

Int J Mol Sci 2020 Jun 17;21(12). Epub 2020 Jun 17.

Experimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.

Retinoblastoma (RB) represents the most common malignant childhood eye tumor worldwide. Several studies indicate that the extracellular matrix (ECM) plays a crucial role in tumor growth and metastasis. Moreover, recent studies indicate that the ECM composition might influence the development of resistance to chemotherapy drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21124322DOI Listing

Association Between Genotype and Phenotype in Consecutive Unrelated Individuals With Retinoblastoma.

JAMA Ophthalmol 2020 Jun 18. Epub 2020 Jun 18.

Department of Genetics, Institut Curie, PSL Research University, Department of Genetics, Paris, France.

Importance: Retinoblastoma (RB) is the most common pediatric intraocular neoplasm. RB is a complex model in which atypical pathogenic variants, modifier genes, imprinting, and mosaicism are known to be associated with the phenotype. In-depth understanding of RB therefore requires large genotype-phenotype studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2020.2100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303903PMC

Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β).

Med Sci Monit 2020 Jun 7;26:e922673. Epub 2020 Jun 7.

Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China (mainland).

BACKGROUND Cell cycle arrest and autophagy have been demonstrated to be involved in various transforming growth factor (TGF)-ß-mediated phenotype alterations of tubular epithelial cells (TECs) and tubulointerstitial fibrosis. But the relationship between cell cycle arrest and the autophagy induced by TGF-ß has not been explored well. MATERIAL AND METHODS The effects of autophagy inhibition on TGF-ß-induced cell cycle arrest in TECs were explored in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.922673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297028PMC

Covid-19 and retinoblastoma: How we manage it.

Eur J Ophthalmol 2020 Jun 19:1120672120936484. Epub 2020 Jun 19.

Unit of Ophthalmology, Ocular Oncology-Retinoblastoma Referral Center, Department of Medicine, Surgery and Neuroscience, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672120936484DOI Listing

Retinoblastoma protein expression and its predictors in triple-negative breast cancer.

NPJ Breast Cancer 2020 5;6:19. Epub 2020 Jun 5.

Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA USA.

Retinoblastoma protein (Rb) is a product of the tumor suppressor gene. Its expression is highly prevalent in luminal breast cancers and is critical to the success of cyclin-dependent kinase (CDK) 4/6 inhibitor therapy. Expression of Rb in triple-negative breast cancer (TNBC), tumors generally associated with basal biology, is not well known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41523-020-0160-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275038PMC

Red reflex examination in reproductive and child health clinics for early detection of paediatric cataract and ocular media disorders: cross-sectional diagnostic accuracy and feasibility studies from Kilimanjaro, Tanzania.

Eye (Lond) 2020 Jun 16. Epub 2020 Jun 16.

International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.

Background/objectives: Late presentation of congenital cataract in the developing world has led to poor outcomes such that cataract is the leading cause of childhood blindness. Our hypothesis was that, sensitivity of red-reflex testing is greater than sensitivity of torchlight examination. We aimed to compare sensitivity of new red reflex screening tools and assess the feasibility of Arclight red reflex screening in the community. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41433-020-1019-5DOI Listing

Proteomic Profiling of Retinoblastoma-Derived Exosomes Reveals Potential Biomarkers of Vitreous Seeding.

Cancers (Basel) 2020 06 12;12(6). Epub 2020 Jun 12.

Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS, Ospedale Pediatrico Bambino Gesù, Piazza Sant'Onofrio 4, 00165 Rome, Italy.

Retinoblastoma (RB) is the most common tumor of the eye in early childhood. Although recent advances in conservative treatment have greatly improved the visual outcome, local tumor control remains difficult in the presence of massive vitreous seeding. Traditional biopsy has long been considered unsafe in RB, due to the risk of extraocular spread. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12061555DOI Listing

Molecular analysis confirms retinoblastoma diagnosis in a histologically undifferentiated retinal tumor in an adult.

Ophthalmic Genet 2020 Jun 16:1-4. Epub 2020 Jun 16.

Ocular Oncology Service, Princess Margaret Cancer Centre , Toronto, ON, Canada.

Retinoblastoma is the most common pediatric intraocular cancer. Rarely, it may develop in adults, with different clinical and imaging characteristics that make the diagnosis a challenge. We present a case of a white retinal tumor in a 42-year-old woman that progressed slowly over 3 years and on enucleation an undifferentiated tumor was found without a conclusive diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13816810.2020.1765398DOI Listing

miR-133a-3p promotes apoptosis and induces cell cycle arrest by targeting CREB1 in retinoblastoma.

Arch Med Sci 2020 25;16(4):941-956. Epub 2019 Jul 25.

Department of Ophthalmology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai' an, Jiangsu, China.

Introduction: Retinoblastoma (RB) is a malignant tumor that is derived from photoreceptors. It is common in children under 3 years old with a family genetic predisposition. MicroRNA-133a-3p (miR-133a-3p) is one of the tumor-related miRNAs that interprets a critical function in the genesis and development of various tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/aoms.2019.86901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286343PMC

Senescence as a therapeutically relevant response to CDK4/6 inhibitors.

Oncogene 2020 Jun 15. Epub 2020 Jun 15.

MRC London Institute of Medical Sciences (LMS), Du Cane Road, London, W12 0NN, UK.

Cyclin-dependent kinases 4 and 6 (CDK4/6) phosphorylate and inhibit retinoblastoma (RB) family proteins. Hyperphosphorylated RB releases E2F transcription factors, activating a transcriptional program that initiates S phase. Due to the critical role that this pathway has in regulating cell cycle progression, inhibiting CDK4/6 is an attractive therapeutic strategy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-020-1354-9DOI Listing

LncRNA LINC00152 Increases the Aggressiveness of Human Retinoblastoma and Enhances Carboplatin and Adriamycin Resistance by Regulating MiR-613/Yes-Associated Protein 1 (YAP1) Axis.

Med Sci Monit 2020 Jun 15;26:e920886. Epub 2020 Jun 15.

Department of Ophthalmology, Ningbo Eye Hospital, Ningbo, Zhejiang, China (mainland).

BACKGROUND Long noncoding RNA (lncRNA) acts as key regulator in human cancers, including retinoblastoma. However, the function of LINC00152 remains largely unknown in retinoblastoma. Thus, this study aimed to explore the role and molecular mechanisms of LINC00152 in retinoblastoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.920886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315805PMC

Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma.

Invest Ophthalmol Vis Sci 2020 Jun;61(6):28

,.

Purpose: Retinoblastoma (RB) is the most common intraocular malignancy in children. Deregulation of several microRNAs (miRNAs) has been identified in RB. However, the specific effect of let-7a on RB remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.61.6.28DOI Listing

Regulating tumor suppressor genes: post-translational modifications.

Signal Transduct Target Ther 2020 Jun 10;5(1):90. Epub 2020 Jun 10.

Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, School of Basic Medicine, Central South University, 410078, Changsha, Hunan, China.

Tumor suppressor genes cooperate with each other in tumors. Three important tumor suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted on chromosome ten (PTEN) are functionally associated and they regulated by post-translational modification (PTMs) as well. PTMs include phosphorylation, SUMOylation, acetylation, and other novel modifications becoming growing appreciated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-020-0196-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293209PMC

Superselective intra-arterial chemotherapy treatment for retinoblastoma: clinical experience from a tertiary referral centre.

Can J Ophthalmol 2020 Jun 8. Epub 2020 Jun 8.

Department of Radiology, Cerrahpasa Medical Faculty, Istanbul, Turkey.

Objective: To evaluate the treatment outcomes of an alternative retrograde superselective ophthalmic artery catheterization (intra-arterial chemotherapy [IAC]), while treating retinoblastoma patients.

Methods: A retrospective review of IAC for 21 treatment-naïve eyes (21 patients, primary group) and 10 eyes of previously treated 9 patients (secondary group). Statistical analysis was performed using Number Cruncher Statistical System 2007, Kaplan-Meier survival analysis, and Fisher's exact test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcjo.2020.04.009DOI Listing

A Multicenter, International Collaborative Study for AJCC-Staging of Retinoblastoma: Treatment Success and Globe Salvage.

Ophthalmology 2020 Jun 8. Epub 2020 Jun 8.

Retinoblastoma Unit, Department of Oncology, Hospital Sant Joan de Déu. Esplugues de Llobregat. Barcelona, Spain.

Purpose: To evaluate the ability of the 8 edition of the American Joint Committee on Cancer (AJCC) Staging to predict local tumor control and globe salvage for children with retinoblastoma (RB).

Design: International, multicenter, registry-based retrospective case series PARTICIPANTS: 2854 eyes of 2097 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.

Methods: International, multicenter, registry-based data was pooled from patients enrolled between January 2001-December 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2020.05.051DOI Listing

Intra-arterial chemotherapy combined with VEC intravenous chemotherapy in the treatment of advanced retinoblastoma.

J BUON 2020 Mar-Apr;25(2):1199-1205

Department of Ophthalmology, Chongqing Bright Eye Hospital, Chongqing, China.

Purpose: To explore the efficacy and safety of intra-arterial chemotherapy (IAC) combined with vincristine + etoposide + carboplatin (VEC) intravenous chemotherapy (IVC) in the treatment of advanced retinoblastoma (RB).

Methods: A total of 86 child patients (98 eyes) newly diagnosed with advanced RB (stage D and E), among whom 42 cases (49 eyes) underwent IVC and IAC combined with local ocular treatment (IVC+IAC group), and 44 cases (49 eyes) were treated with IAC combined with local ocular treatment (IAC group). At 4 weeks after treatment, the maximum diameter and thickness of the tumor were evaluated, the expression levels of serum markers [vascular endothelial growth factor (VEGF), neurone specific enolase (NSE), Livin and Survivin] were assessed. Read More

View Article

Download full-text PDF

Source

Next-Generation Sequencing Data Analysis on Pool-Seq and Low-Coverage Retinoblastoma Data.

Interdiscip Sci 2020 Jun 9. Epub 2020 Jun 9.

Department of Computer Engineering, Ankara Yildirim Beyazit University, 06010, Ankara, Turkey.

Next-generation sequencing (NGS) is related to massively parallel or deep deoxyribonucleic acid (DNA) sequencing technology which has revolutionized genomic researches in recent years. Although the cost of generating NGS data was decreased compared to the one at the time of emerging this technology, its cost might still be somewhat a problem. Hence, new strategies as pool-seq and low-coverage NGS data have been developed to overcome the cost problem. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12539-020-00374-8DOI Listing

Relationship between cell cycle and diel transcriptomic changes in metabolism in a unicellular red alga.

Plant Physiol 2020 Jun 9. Epub 2020 Jun 9.

National Institute of Genetics CITY: MIshima, Shizuoka POSTAL_CODE: 411-8540 Japan [JP].

Metabolism, cell cycle stages, and related transcriptomes in eukaryotic algae change with the diel cycle of light availability. In the unicellular red alga Cyanidioschyzon merolae, the S and M phases occur at night. To examine how diel transcriptomic changes in metabolic pathways are related to the cell cycle and to identify all genes, for which mRNA levels change depending on the cell cycle, we examined diel transcriptomic changes in C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1104/pp.20.00469DOI Listing

The top 10 retinoblastoma research priorities in Canada as determined by patients, clinicians and researchers: a patient-oriented priority-setting partnership.

CMAJ Open 2020 Apr-Jun;8(2):E420-E428. Epub 2020 Jun 9.

Department of Ophthalmology and Vision Sciences (Flegg, Gelkopf, Dimaras), The Hospital for Sick Children, Toronto, Ont.; Department of Neuroscience (Johnson), Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, Fla.; Department of Ophthalmology and Vision Sciences (Dimaras), Faculty of Medicine, and Division of Clinical Public Health (Dimaras), Dalla Lana School of Public Health, University of Toronto; Child Health Evaluative Sciences Program (Dimaras) and Centre for Global Child Health (Dimaras), SickKids Research Institute, Toronto, Ont.

Background: Retinoblastoma is a childhood cancer of the eye that can have lifelong effects on patients and families. The purpose of this study was for people affected by retinoblastoma, clinicians and researchers to jointly determine the top 10 retinoblastoma research priorities in Canada.

Methods: An adaptation of the James Lind Alliance Priority Setting Partnership (PSP) methodology was employed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.9778/cmajo.20190221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286623PMC

Long noncoding RNAs as potential biomarkers in retinoblastoma: a systematic review and meta-analysis.

Cancer Cell Int 2020 29;20:201. Epub 2020 May 29.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, School of Medicine, Shanghai, 200080 China.

Background: Retinoblastoma is the most common malignant rare intraocular tumor of childhood. Long noncoding RNAs (lncRNAs) have been reported participating in its progression, but their significance remains inconclusive. We conducted this systematic review and meta-analysis to explore specific lncRNA biomarker in patients with retinoblastoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12935-020-01281-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257223PMC

Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin.

Trends Cell Biol 2020 Jun 5. Epub 2020 Jun 5.

Faculty of Life Sciences and Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel. Electronic address:

The E2F family of transcriptional regulators sits at the center of cell cycle gene expression and plays vital roles in normal and cancer cell cycles. Whereas control of E2Fs by the retinoblastoma family of proteins is well established, much less is known about their regulation by ubiquitin pathways. Recent studies placed the Skp1-Cul1-F-box-protein (SCF) family of E3 ubiquitin ligases with the F-box protein Cyclin F at the center of E2F regulation, demonstrating temporal proteolysis of both activator and atypical repressor E2Fs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcb.2020.05.002DOI Listing

A Multicenter, International Collaborative Study for AJCC-Staging of Retinoblastoma: Metastasis-Associated Mortality.

Ophthalmology 2020 Jun 5. Epub 2020 Jun 5.

Retinoblastoma Unit, Department of Oncology, Hospital Sant Joan de Déu. Esplugues de Llobregat. Barcelona, Spain.

Purpose: To evaluate the ability of the 8 edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma(RB).

Design: International, multicenter, registry-based retrospective case series PARTICIPANTS: 2190 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.

Methods: Patient-specific data fields for RB were designed by participating eye cancer specialists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2020.05.050DOI Listing

Hemodynamic Changes Associated with Mydriatic Eye Drop Administration in Anesthetized Pediatric Patients.

Ocul Oncol Pathol 2020 May 30;6(3):203-209. Epub 2019 Oct 30.

Department of Surgery, Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Background: Dilating eye drops are routinely used in pediatric retinoblastoma patients during anesthetized ophthalmologic exams. Information on the systemic effects of ocular mydriatics, especially in anesthetized pediatric patients, is limited.

Objective: The primary aim of this study was to analyze hemodynamic changes during mydriatic eye drop administration in anesthetized pediatric patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000500593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250338PMC

Bioinformatics analyses of retinoblastoma reveal the retinoblastoma progression subtypes.

PeerJ 2020 21;8:e8873. Epub 2020 May 21.

Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, China.

Introduction: Retinoblastoma (RB) is one common pediatric malignant tumor with dismal outcomes. Heterogeneity of RB and subtypes of RB were identified but the association between the subtypes of RB and RB progression have not been fully investigated.

Methods: Four public datasets were downloaded from Gene expression omnibus and normalization was performed to remove batch effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7717/peerj.8873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246025PMC

Inhibiting the Progression of Human Retinoblastoma Cell by Downregulation of MMP-2/MMP-9 Using Short Hairpin RNAs (shRNAs) In Vitro.

J Ophthalmol 2020 13;2020:4912347. Epub 2020 May 13.

Department of General Surgery, Affiliated People's Hospital, Jiangsu University, Zhenjiang 212002, China.

Objective: To investigate the effect of downregulated matrix metalloproteinases (MMPs) gene on the proliferation, apoptosis, cell cycle, migration, and invasion of human retinoblastoma (RB) cell line in vitro.

Methods: Small hairpin RNA (shRNA) targeting MMP-2/MMP-9 was designed and transfected into WER1-Rb-1 cells. 48 hours after transfection, qRT-PCR and western blot technique were used to investigate the inhibitory effect of MMP-2 and MMP-9 shRNAs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/4912347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244976PMC

Let's Make Retinoblastoma a Zero-Death Cancer.

Authors:
Ann Marie Leahey

Ophthalmol Retina 2020 06;4(6):640-641

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oret.2020.03.016DOI Listing

Benefit of Patching Therapy to Minimize Amblyopia After Retinoblastoma Treatment.

Ophthalmol Retina 2020 06;4(6):567

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oret.2020.01.013DOI Listing

Molecular Genetics of Intraocular Tumors.

Semin Ophthalmol 2020 Apr 7;35(3):174-181. Epub 2020 Jun 7.

David G Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Harvard Medical School , Boston, MA, USA.

Purpose: To explore the value of molecular technologies in the pathologic evaluation, diagnosis, and treatment of retinoblastoma and uveal melanoma.

Methods: Review of the peer-reviewed literature on the molecular pathology of primary intraocular tumors.

Conclusion: Molecular tests are playing an increasingly important role in the diagnosis of intraocular tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/08820538.2020.1776343DOI Listing

Abnormal Red Reflex: Etiologies in a Pediatric Ophthalmology Population.

Clin Pediatr (Phila) 2020 Jul;59(8):760-765

Baylor College of Medicine, Houston, TX, USA.

Children who present with an abnormal red reflex (ARR) are often referred to ophthalmology due to concern for retinoblastoma. However, an ARR can indicate a wide variety of pathologies, all of which have the potential to develop amblyopia and irreversible vision loss. In this retrospective cohort study, we demonstrate that children who presented with an ARR had a mean age of 22. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0009922820916892DOI Listing