21,392 results match your criteria Retinoblastoma


A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family.

PLoS One 2018 12;13(12):e0208110. Epub 2018 Dec 12.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, United States of America.

The propensity for differentiation varies substantially across human pluripotent stem cell (hPSC) lines, greatly restricting the use of hPSCs for cell replacement therapy or disease modeling. Here, we investigate the underlying mechanisms and demonstrate that activation of the retinoblastoma (Rb) pathway in a transient manner is important for differentiation. In prior work, we demonstrated that pre-treating hPSCs with dimethylsulfoxide (DMSO) before directed differentiation enhanced differentiation potential across all three germ layers. Read More

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December 2018
1 Read

Lens dose-response prediction modeling and cataract incidence in retinoblastoma patients after lens-sparing or whole-eye radiotherapy.

Int J Radiat Oncol Biol Phys 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiation Oncology, Keck School of Medicine of USC and Children's Hospital Los Angeles, Los Angeles, CA. Electronic address:

Purpose: We retrospectively assessed the incidence of cataracts in retinoblastoma (Rb) patients treated with either lens-sparing (LSRT) or whole-eye radiotherapy (WERT). A secondary aim of this study was to model the dose-response risk of cataract.

Methods: We reviewed 65 retinoblastoma patients treated with radiotherapy (RT) at XXXX from 1997-2015. Read More

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December 2018

DUSP1 promotes senescence of retinoblastoma cell line SO-Rb5 cells by activating AKT signaling pathway.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7628-7632

Department of Ophthalmology, Mudanjiang Medical University Hongqi Hosptial, Mudanjiang, Heilongjiang, China.

Objective: Retinoblastoma seriously threats to human health and life. Molecular targeted therapy of retinoblastoma supplies the direction of research in the future. This study aims to investigate the impact of DUSP1 on human retinoblastoma SO-Rb5 cell senescence. Read More

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November 2018

Methylation‑associated silencing of miR‑128 promotes the development of esophageal cancer by targeting COX‑2 in areas with a high incidence of esophageal cancer.

Int J Oncol 2018 Dec 4. Epub 2018 Dec 4.

Cancer Institute, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.

Esophageal cancer is one of the most common cancer types in the world, with a widely varying incidence between different regions. Zinc deficiency (ZD) is very common in high‑risk areas for esophageal cancer. Dietary ZD is reported to be associated with esophageal squamous cell carcinoma (ESCC). Read More

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December 2018

Targeting retinoblastoma protein phosphorylation in combination with EGFR inhibition in pancreatic cancer cells.

Int J Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Biology, Pace University, Pleasantville, NY 10570, USA.

Pancreatic ductal adenocarcinoma (PDAC) remains a particularly lethal disease that is resistant to targeted therapies. Tyrosine kinase inhibitors (TKIs), including erlotinib and gefitinib, which block the action of the human epidermal growth factor receptor type 1 receptor, provide small increases in patient survival when administered with gemcitabine. The retinoblastoma (Rb) tumor suppressor protein is an additional target in pancreatic cancer, due to its documented inactivation in PDAC. Read More

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December 2018

PIN1 in Cell Cycle Control and Cancer.

Front Pharmacol 2018 26;9:1367. Epub 2018 Nov 26.

Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.

Cell cycle progression is tightly controlled by many cell cycle-regulatory proteins that are in turn regulated by a family of cyclin-dependent kinases (CDKs) through protein phosphorylation. The peptidyl-prolyl / isomerase PIN1 provides a further post-phosphorylation modification and functional regulation of these CDK-phosphorylated proteins. PIN1 specifically binds the phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif of its target proteins and catalyzes the / isomerization on the pSer/Thr-Pro peptide bonds. Read More

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November 2018

Retinoblastoma Binding Protein 5 Correlates with the Progression in Hepatocellular Carcinoma.

Biomed Res Int 2018 7;2018:1073432. Epub 2018 Nov 7.

Department of Pathology, Taizhou People's Hospital, Jiangsu Province, China.

Hepatocellular carcinoma (HCC) is one of the most common malignancy tumors with insidious onset, rapid development and metastasis, and poor prognosis. Therefore, it is necessary to understand molecular mechanisms of HCC and identify clinically useful biomarkers for it. This study aimed to investigate the role of retinoblastoma binding protein 5 (RBBP5) in HCC. Read More

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November 2018

[Pharmacological profile and clinical findings of palbociclib (IBRANCE capsule 25 mg/125 mg)].

Nihon Yakurigaku Zasshi 2018 ;152(6):306-318

Medical Affairs Oncology, Pfizer Japan Inc.

Palbociclib is the world's first cyclin dependent kinase (CDK) 4 and 6 inhibitor. It's believed that palbociclib stops the cell cycle progression by inhibiting the activity of the complex consisting of CDK 4/6 and cyclin D, and suppresses tumor growth. In preclinical study using nonclinical model, it was confirmed that most of the cell lines sensitive to palbociclib are estrogen receptor (ER) positive. Read More

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January 2018

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression.

Mol Cell 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Urology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Electronic address:

Aberrant expression of programmed death ligand-1 (PD-L1) in tumor cells promotes cancer progression by suppressing cancer immunity. The retinoblastoma protein RB is a tumor suppressor known to regulate the cell cycle, DNA damage response, and differentiation. Here, we demonstrate that RB interacts with nuclear factor κB (NF-κB) protein p65 and that their interaction is primarily dependent on CDK4/6-mediated serine-249/threonine-252 (S249/T252) phosphorylation of RB. Read More

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December 2018
1 Read

Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway.

BMC Cancer 2018 Dec 10;18(1):1230. Epub 2018 Dec 10.

Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, No.126, Xiantai Street, Changchun, Jilin, 130033, China.

Background: Curcumin, a primary active ingredient extracted from the Curcuma longa, has been recently identified as a potential anti-tumor agent in multiple kinds of cancers. However, the effect of curcumin on retinoblastoma (Rb) is still unclear. Therefore, we attempted to reveal the functional impacts and the underlying mechanisms of curcumin in Rb cells. Read More

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December 2018
1 Read

Tenascin-C Modulates Cell Cycle Progression to Enhance Tumour Cell Proliferation through AKT/FOXO1 Signalling in Pancreatic Cancer.

J Cancer 2018 31;9(23):4449-4462. Epub 2018 Oct 31.

School of medicine, Nankai University, 94 Weijin Road, Tianjin 300071, China.

Pancreatic ductal adenocarcinoma (PDAC) is a disease with an extremely poor prognosis that is characterized by a rich extracellular matrix (ECM). Tenascin-C (TNC) is a component of the ECM and plays a role in tumour progression. In this study, we reported that TNC is overexpressed in PDAC tissues and is correlated with tumour stage and cyclin D1 expression. Read More

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October 2018

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs.

Authors:
Robert Roskoski

Pharmacol Res 2018 Nov 30. Epub 2018 Nov 30.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC, 28742-8814, United States. Electronic address:

Cyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are required for the regulation and expression of the large number of components necessary for the passage through the cell cycle. The concentrations of the CDKs are generally constant, but their activities are controlled by the oscillation of the cyclin levels during each cell cycle. Additional CDK family members play significant roles in a wide range of activities including gene transcription, metabolism, and neuronal function. Read More

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November 2018
1 Read

Expression of MT4-MMP, EGFR and RB in triple negative breast cancer strongly sensitizes tumors to erlotinib and palbociclib combination therapy.

Clin Cancer Res 2018 Nov 30. Epub 2018 Nov 30.

Medical Oncology, CHU Liege and Liège University.

Purpose: Here, we investigated the clinical relevance of an unprecedented combination of three biomarkers in triple-negative breast cancer (TNBC), both in human samples and in patient-derived xenografts of TNBC (PDX-TNBC): epidermal growth factor receptor (EGFR), its recently identified partner (MT4-MMP) and retinoblastoma protein (RB).

Experimental Design: Immunohistochemistry (IHC) analyses were conducted on human and PDX-TNBC samples to evaluate the production of the three biomarkers. The sensitivity of cancer cells expressing or not MT4-MMP to anti-EGFR (E: erlotinib) or anti-CDK4/6 inhibitor (P: palbociclib) was evaluated, in vitro in 2D and 3D proliferation assays and, in vivo using xenografts and PDX-TNBC displaying different RB, MT4-MMP and EGFR status after single (E or P) or combined (E+P) treatments. Read More

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November 2018

Microperimetry and swept-source optical coherence tomography in the assessment of the preferred retinal locus in a child with macular retinoblastoma in the remaining eye.

J AAPOS 2018 Nov 28. Epub 2018 Nov 28.

Moorfields Eye Hospital, Moorfields NHS Trust, London, United Kingdom; Retinoblastoma Unit, Royal London Hospital, Barts Health NHS Trust, London, United Kingdom; National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital, NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.

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November 2018

Involvement of the STAT5-CyclinD/CDK4-pRb pathway in beta cell proliferation stimulated by prolactin during pregnancy.

Am J Physiol Endocrinol Metab 2018 Dec 4. Epub 2018 Dec 4.

Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, China.

During pregnancy, maternal pancreatic beta cells undergo a compensatory expansion in response to the state of insulin resistance, where prolactin (PRL) plays a major role. Retinoblastoma protein (Rb) has been shown to critically regulate islet proliferation and function. The aim of the study was to explore the role of Rb in beta cell mass expansion during pregnancy. Read More

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December 2018
3 Reads

TCF19 enhances cell proliferation in hepatocellular carcinoma by activating the ATK/FOXO1 signaling pathway.

Neoplasma 2018 Aug 9. Epub 2018 Aug 9.

Department of General Surgery, Guangdong Second Provincial General Hospital, Guangzhou, China.

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies because of its complexity, high metastasis, recurrence and limited treatment options. Reports state that transcription factor 19 (TCF19) is related to the susceptibility to chronic HBV infection and that it strongly increases the risk of HCC occurrence, but its molecular mechanisms remain unknown. This study analyzed the datasets and confirmed that TCF19 is significantly increased in HCC cell lines and tissues. Read More

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Genome-wide identification of RETINOBLASTOMA RELATED 1 binding sites in Arabidopsis reveals novel DNA damage regulators.

PLoS Genet 2018 Nov 30;14(11):e1007797. Epub 2018 Nov 30.

University of Hamburg, Department of Developmental Biology, Hamburg, Germany.

Retinoblastoma (pRb) is a multifunctional regulator, which was likely present in the last common ancestor of all eukaryotes. The Arabidopsis pRb homolog RETINOBLASTOMA RELATED 1 (RBR1), similar to its animal counterparts, controls not only cell proliferation but is also implicated in developmental decisions, stress responses and maintenance of genome integrity. Although most functions of pRb-type proteins involve chromatin association, a genome-wide understanding of RBR1 binding sites in Arabidopsis is still missing. Read More

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November 2018

Neoplastic Meningitis: A Study from a Tertiary Care Hospital from Coastal India.

J Cytol 2018 Oct-Dec;35(4):255-259

Department of Cellular Pathology, Leighton Hospital, Crewe, Cheshire, United Kingdom.

Introduction: Neoplastic involvement of cerebrospinal fluid (CSF) secondary to known or unknown primaries elsewhere is a poor prognostic factor and is equivalent to stage IV disease.

Aim: The aim of the study is to analyse the cytological features of neoplastic meningitis in a tertiary care center.

Materials And Methods: A retrospective study of 400 consecutive CSF samples was done in the cytology laboratory of our hospital. Read More

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December 2018
2 Reads

Myoblasts rely on TAp63 to control basal mitochondria respiration.

Aging (Albany NY) 2018 Nov;10(11):3558-3573

Department of Experimental Medicine and TOR, University of Rome "Tor Vergata", Rome, Italy.

p53, with its family members p63 and p73, have been shown to promote myoblast differentiation by regulation of the function of the retinoblastoma protein and by direct activation of p21 and p57, promoting cell cycle exit. In previous studies, we have demonstrated that the TAp63γ isoform is the only member of the p53 family that accumulates during myoblasts differentiation, and that its silencing led to delay in myotube fusion. To better dissect the role of TAp63γ in myoblast physiology, we have generated both sh-p63 and Tet-On inducible TAp63γ clones. Read More

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November 2018
7 Reads

Middle meningeal artery occlusion for intra-arterial chemotherapy of retinoblastoma.

Interv Neuroradiol 2018 Nov 28:1591019918815286. Epub 2018 Nov 28.

1 Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland.

We report the intentional occlusion of the middle meningeal artery arising from the lacrimal artery, a novel technique to improve drug delivery in a 14-month-old boy with a history of right sporadic unilateral cavitary retinoblastoma group D. The patient was referred to our institution for intra-arterial chemotherapy after two systemic chemotherapy treatments. The digital subtraction angiography showed a large middle meningeal artery arising from the right lacrimal artery and decrease choroidal enhancement thus decreased flow to the tumor. Read More

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November 2018

Single cell RNA-sequencing identifies a metabolic aspect of apoptosis in Rbf mutant.

Nat Commun 2018 11 27;9(1):5024. Epub 2018 Nov 27.

Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL, 60607, USA.

The function of Retinoblastoma tumor suppressor (pRB) is greatly influenced by the cellular context, therefore the consequences of pRB inactivation are cell-type-specific. Here we employ single cell RNA-sequencing (scRNA-seq) to profile the impact of an Rbf mutation during Drosophila eye development. First, we build a catalogue of 11,500 wild type eye disc cells containing major known cell types. Read More

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November 2018
11 Reads

Long noncoding RNA NEAT1 promotes the growth of human retinoblastoma cells via regulation of miR-204/CXCR4 axis.

J Cell Physiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Ophthalmology, the First Hospital of Jilin University, Changchun, China.

Retinoblastoma (RB) is an aggressive eye cancer of infancy and childhood with high mortality. Studies have shown that long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) is closely related to the progression of multiple cancers. However, its role in RB remains unknown. Read More

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November 2018
4 Reads

HPV-associated neuroendocrine carcinomas of the head and neck in FNA biopsies: Clinicopathologic features of a rare entity.

Cancer Cytopathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: The majority of human papillomavirus (HPV)-associated oropharyngeal carcinomas are squamous cell carcinomas; however, there are rare reports of HPV-associated neuroendocrine carcinomas (HPV-NECs) in the upper aerodigestive tract. The aim of this study was to characterize the diagnostic features of fine-needle aspiration (FNA) cases of head and neck HPV-NEC.

Methods: Cytology cases of HPV-NEC were identified over a 3-year period from 2 institutions. Read More

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November 2018
1 Read

LncRNA XIST promotes the epithelial to mesenchymal transition of retinoblastoma via sponging miR-101.

Eur J Pharmacol 2018 Nov 22;843:210-216. Epub 2018 Nov 22.

Ophthalmology of Xi'an First Hospital, Xi'an, Shaanxi 710002, China.

Accumulating evidence demonstrated that abnormal expression of long non-coding RNAs (lncRNAs) was closely associated with cancer development including retinoblastoma (RB). LncRNA X inactive specific transcript (XIST) has been found to function as an oncogene or a tumor suppressor in several cancers. However, the role and underlying mechanism of XIST in RB have not been clarified. Read More

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November 2018
1 Read

Targeting tyrosine kinases for treatment of ocular tumors.

Arch Pharm Res 2018 Nov 23. Epub 2018 Nov 23.

Fight Against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, 03080, Republic of Korea.

Uveal melanoma is the most common intraocular primary malignant tumor in adults, and retinoblastoma is the one in children. Current mainstay treatment options include chemotherapy using conventional drugs and enucleation, the total removal of the eyeball. Targeted therapies based on profound understanding of molecular mechanisms of ocular tumors may increase the possibility of preserving the eyeball and the vision. Read More

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November 2018
4 Reads

The role of vitamin D in the pathogenesis of ocular diseases.

Folia Med Cracov 2018 ;58(2):103-118

Department of Pathophysiology, Jagiellonian University Medical College, Czysta 18, Kraków, Poland.

The prevalence of vitamin D deficiency in the American and European population is estimated to be extremely high. Although fewer people today su er from serious health problems related to calcium and phosphate metabolism resulting from vitamin D deficiency, there are more and more studies suggesting that calcitriol may play an important role in the pathogenesis of other diseases in virtually every body system. A growing body of research shows that through its ubiquitously expressed receptor, calcitriol displays potent anti-angiogenic an anti-inflammatory activity. Read More

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January 2018
5 Reads

On the mechanism of the cell cycle control of suspension-cultured tobacco cells after exposure to static magnetic field.

Plant Sci 2018 Dec 10;277:139-144. Epub 2018 Aug 10.

Department of Biology, University of Mazandaran, Babolsar, Mazandaran, Iran.

One of the main sites of the magnetic fields influence on living cells is the cell cycle. The intensity of this influence however, varies depending on the cell type and the duration of the treatment. Suspension of cultured tobacco cells (Nicotiana tabacum cv. Read More

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December 2018
5 Reads

Upregulation of FOXM1 leads to diminished drug sensitivity in myeloma.

BMC Cancer 2018 Nov 21;18(1):1152. Epub 2018 Nov 21.

Department of Pathology, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa, 52242, USA.

Background: Following up on previous work demonstrating the involvement of the transcription factor forkhead box M1 (FOXM1) in the biology and outcome of a high-risk subset of newly diagnosed multiple myeloma (nMM), this study evaluated whether FOXM1 gene expression may be further upregulated upon tumor recurrence in patients with relapsed multiple myeloma (rMM). Also assessed was the hypothesis that increased levels of FOXM1 diminish the sensitivity of myeloma cells to commonly used myeloma drugs, such as the proteasome inhibitor bortezomib (Bz) and the DNA intercalator doxorubicin (Dox).

Methods: FOXM1 message was evaluated in 88 paired myeloma samples from patients with nMM and rMM, using gene expression microarrays as measurement tool. Read More

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November 2018
4 Reads

Lipoma of the Neck.

Open Access Maced J Med Sci 2018 Oct 23;6(10):1875-1877. Epub 2018 Oct 23.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery General Skobelev Nr 79, Sofia, Bulgaria.

Background: Lipomas are benign formations with the mesenchymal origin, which are found in the head and neck region in a very small percentage of cases. In these cases, they usually occur in the posterior neck and usually grow very slowly without causing complaints. However, when they cover the front of the neck, it is necessary to confirm the adipose origin of a tumour and to exclude the connection with the thyroid gland. Read More

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October 2018
2 Reads

Blood Flow in Monocular Retinoblastoma Assessed by Color Doppler and Correlations With High-Risk Pathologic Features.

Invest Ophthalmol Vis Sci 2018 Nov;59(13):5441-5446

Department of Radiology and Ultrasound, University of São Paulo, São Paulo, São Paulo, Brazil.

Purpose: To use color Doppler to analyze blood flow in the retrobulbar central retinal artery (CRA) and central retinal vein (CRV) in monocular retinoblastoma.

Methods: This prospective study included patients with group D and E retinoblastomas managed with only enucleation. Peak blood velocities were assessed in the CRA and CRV of tumor-containing eyes (CRAv and CRVv, respectively). Read More

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November 2018
1 Read

Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker.

PLoS One 2018 19;13(11):e0207483. Epub 2018 Nov 19.

Biochemistry and Cancer Biology Divisions, Basic Science Department, Ponce Health Sciences University-Ponce Research Institute, Ponce, Puerto Rico.

Prediction of lung cancer metastasis relies on post-resection assessment of tumor histology, which is a severe limitation since only a minority of lung cancer patients are diagnosed with resectable disease. Therefore, characterization of metastasis-predicting biomarkers in pre-resection small biopsy specimens is urgently needed. Here we report a biomarker consisting of the phosphorylation of the retinoblastoma protein (Rb) on serine 249 combined with elevated p39 expression. Read More

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November 2018
2 Reads

Commentary: Periocular topotecan for retinoblastoma.

Indian J Ophthalmol 2018 Dec;66(12):1838-1839

Department of Vitreoretina and Ocular Oncology, Medical Research Foundation, 18, College Road, Chennai, India.

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December 2018

Periocular topotecan for vitreous seeds in retinoblastoma.

Indian J Ophthalmol 2018 Dec;66(12):1833-1838

National Retinoblastoma Foundation, Department of Ophthalmic and Facial Plastic Surgery and Ocular Oncology, Centre for Sight Superspeciality Eye Hospital, Hyderabad, Telangana, India.

Purpose: Refractory or recurrent vitreous seeds account for a large proportion of failure of eye salvage in retinoblastoma. The purpose of this study is to evaluate the efficacy of periocular topotecan (POT) in the management of vitreous seeds in retinoblastoma.

Methods: Retrospective, interventional study of patients with retinoblastoma with vitreous seeds who received POT concurrent with intravenous chemotherapy (IVC). Read More

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December 2018
3 Reads

Giant cell tumour of frontal bone in a patient with bilateral retinoblastoma.

Arch Soc Esp Oftalmol 2018 Nov 15. Epub 2018 Nov 15.

Unidades de Oculoplastia-órbita, RETICS OftaRed, Instituto de Salud Carlos III, Madrid, España; Unidades de Retina y Oncología Ocular, UGC Oftalmología, Hospital Universitario Virgen Macarena, Sevilla, España.

A case is presented of a 5 year-old patient with bilateral hereditary retinoblastoma treated with radiotherapy in the right eye and enucleation of the left eye. After three years without evidence of progression, the patient presented with a right orbital mass that compromised the frontal bone. After surgical excision, the histology analysis was consistent with a diagnosis of giant cell tumour. Read More

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November 2018

Epigenetic knockdown of Notch1 inhibits hepatitis B virus X protein‑induced hepatocarcinogenesis of L02/HBx cells.

Oncol Rep 2018 Nov 15. Epub 2018 Nov 15.

Department of Clinical Laboratory, Chengdu Military General Hospital, Chengdu Military District, Chengdu, Sichuan 610083, P.R. China.

The present study aimed to investigate the effects of Notch1 on the development of hepatitis B virus X protein (HBx)‑induced hepatocarcinogenesis. The L02/HBx cells were transfected with a short hairpin RNA (shRNA) specially targeting Notch1 (Notch1‑shRNA). The mRNA and protein expression levels of Notch1 signaling pathway‑related molecules (Notch1, Hes1 and NICD) were detected after knockdown of Notch1. Read More

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November 2018
3 Reads

Clinicopathological and genomic comparisons between different histologic components in combined small cell lung cancer and non-small cell lung cancer.

Lung Cancer 2018 Nov 9;125:282-290. Epub 2018 Oct 9.

Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Objective: Histologic transformation from adenocarcinoma to small cell lung cancer (SCLC) is one of the mechanisms of acquired resistance after epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment. Furthermore, de novo combined SCLC/non-small cell lung cancer (NSCLC) have occasionally been reported; however, their mutational statuses and clinicopathological features have not yet been elucidated. In this study, we aimed to profile the genetic backgrounds of these 2 different histologic components by investigating patients with de novo combined SCLC/NSCLC as well as those with lung adenocarcinoma who experienced SCLC transformation after TKI treatment. Read More

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November 2018

Evidence of predisposing epimutation in retinoblastoma.

Hum Mutat 2018 Nov 14. Epub 2018 Nov 14.

Medical Genetics, University of Siena, Siena, Italy.

Retinoblastoma (RB), which represents the most common childhood eye cancer, is caused by biallelic inactivation of RB1 gene. Promoter hypermethylation is quite frequent in RB tissues but conclusive evidence of soma-wide predisposing epimutations is currently scant. Here, 50 patients who tested negative for RB1 germline sequence alterations were screened for aberrant promoter methylation using methylation-specific MLPA. Read More

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November 2018
3 Reads

Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma.

JAMA Ophthalmol 2018 Oct 25. Epub 2018 Oct 25.

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Importance: Choroidal hemangiomas are defined by a thickened choroid owing to vessel overgrowth, which may increase the intraocular pressure and lead to glaucoma. Choroidal hemangioma and glaucoma often co-occur in patients with Sturge-Weber syndrome, a rare neurocutaneous disorder characterized by capillary malformations.

Objective: To determine whether the mutation found in most capillary malformations, GNAQ R183Q (c. Read More

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October 2018
4 Reads

Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma.

FEBS Lett 2018 Nov 11. Epub 2018 Nov 11.

Department of Nanotechnology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint-based reconstruction and analysis approaches to identify and explain RB-specific survival strategies, which are RB tumor specific. Read More

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November 2018

Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer.

J Oncol 2018 16;2018:3812581. Epub 2018 Oct 16.

Department of System Biology, Unit of Biochemistry and Molecular Biology, University of Alcalá, Alcalá de Henares, Spain.

We reported that insulin receptor substrate 4 (IRS-4) levels increased in tissue from colorectal cancer (CRC) patients and promoted retinoblastoma-cyclin-dependent kinase activation. The aim of the present study was to evaluate the effect of IRS-4 on IGF-1 receptor pathway and its impact on procaspase 3 and PARP expression in RKO and HepG2 cancer cell lines. The results obtained were compared with those obtained from biopsies of patients with CRC (n = 18), tubulovillous adenomas (TA) (n = 2) and in matched adjacent normal colorectal (MANC) tissue (n = 20). Read More

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October 2018
4 Reads

ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma.

Oncogene 2018 Nov 6. Epub 2018 Nov 6.

Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

Retinoblastoma is the most common intraocular cancer in children. While the primary tumor can often be treated by local or systemic chemotherapy, metastatic dissemination is generally resistant to therapy and remains a leading cause of pediatric cancer death in much of the world. In order to identify new therapeutic targets in aggressive tumors, we sequenced RNA transcripts in five snap frozen retinoblastomas which invaded the optic nerve and five which did not. Read More

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November 2018
4 Reads

Diagnosis of Bilateral Retinocytoma in an Adolescent Patient Using Multimodal Imaging and Genetic Testing.

Ophthalmic Surg Lasers Imaging Retina 2018 Oct;49(10):812-814

A 12-year-old male presented for evaluation of asymptomatic bilateral retinal tumors. Both eyes contained whitish-gray retinal tumors with intralesional calcifications. Enhanced depth optical coherence tomography and high-resolution (20 MHz) ultrasonography narrowed the differentiation diagnosis to astrocytic hamartoma versus retinocytoma. Read More

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October 2018
4 Reads

Antiproliferative activity of microRNA-125a and its molecular targets.

Microrna 2018 Nov 4. Epub 2018 Nov 4.

Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Caserta. Italy.

Background: MicroRNA-125a is present in all animals with bilateral symmetry and displays a conserved nucleotide sequence with a section of 11 bases including the seed region that is identical in all considered species. It primarily downregulates the expression of LIN28, thereby promoting cell differentiation and larval phase transitions in nematodes, mammals and insects.

Objective: In this review we focus on the cellular control of miR-125a expression and its antiproliferative activity. Read More

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November 2018
4 Reads

miR‑34a regulates the chemosensitivity of retinoblastoma cells via modulation of MAGE‑A/p53 signaling.

Int J Oncol 2019 Jan 31;54(1):177-187. Epub 2018 Oct 31.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

The present study aimed to explore the combined role of microRNA (miR)-34a, melanoma antigen-A (MAGE‑A) and p53 in altering the chemosensitivity of retinoblastoma (RB) cells. Human RB and adjacent tumor tissues, as well as human RB cell lines (HXO‑Rb44, SO‑Rb50, Y79 and WERI‑Rb-1) were used. In addition, four chemotherapeutic drugs, including carboplatin, etoposide, Adriamycin and vincristine, were used to treat the cell lines, in order to evaluate the sensitivity of RB cells. Read More

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January 2019
1 Read

Retinoblastoma in Asia.

Eye (Lond) 2018 Nov 1. Epub 2018 Nov 1.

Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Sankara Nethralaya, Chennai, 600006, Tamil Nadu, India.

Asia-Pacific region bears a significant global burden of retinoblastoma (RB), therefore understanding RB in Asia-Pacific region is important. Based on the year 2013 population estimates, 43% (3452 of 8099 children) of the global burden of RB lives in 6 countries of Asia-Pacific region: 1486 children in India, 1103 children in China, 277 children in Indonesia, 260 children in Pakistan, 184 children in Bangladesh, 142 children in Philippines. There exists a wide disparity, technological and socio-economical, within countries in this region resulting in a varied pattern of clinical presentation and survival varies. Read More

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November 2018
1 Read

Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14.

Sci Rep 2018 Nov 1;8(1):16152. Epub 2018 Nov 1.

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

The KIF14 locus is gained and overexpressed in various malignancies, with prognostic relevance. Its protein product, a mitotic kinesin, accelerates growth of normal mammary epithelial cells in vitro and retinoblastoma tumours in a mouse model, while KIF14 knockdown blocks growth of brain, liver, ovarian, breast, prostate, and other tumour cells and xenografts. However, the tumour-initiating effects of Kif14 overexpression have not been studied. Read More

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November 2018
2 Reads

Leiomyosarcoma of the Urinary Bladder in Adult Patients: A Systematic Review of the Literature and Meta-Analysis.

Urol Int 2018 Nov 1:1-6. Epub 2018 Nov 1.

Department of Urology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.

Purpose: Leiomyosarcoma of the urinary bladder is exceedingly rare. Most clinicians come across only a few cases during their career, and information regarding treatment and outcome is scattered in the scientific literature. Interested clinicians and patients have to undertake troublesome search for treatment and outcome information. Read More

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November 2018
2 Reads

p107 Deficiency Increases Energy Expenditure by Inducing Brown-Fat Thermogenesis and Browning of White Adipose Tissue.

Mol Nutr Food Res 2018 Nov 1:e1801096. Epub 2018 Nov 1.

Centro de Investigación en Medicina Molecular (CIMUS), Universidade de Santiago de Compostela and Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), 15782, Santiago de Compostela, Spain.

Scope: The tumor suppressor p107, a pocket protein member of the retinoblastoma susceptibility protein family, plays an important role in the cell cycle and cellular adipocyte differentiation. Nonetheless, the mechanism by which it influences whole body Energy homeostasis is unknown.

Methods And Results: The phenotype of p107 knockout (KO) mixed-background C57BL6/129 mice phenotype is studied by focusing on the involvement of white and brown adipose tissue (WAT and BAT) in energy metabolism. Read More

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November 2018
9 Reads

Panaxydol Derived from Panax ginseng Inhibits G Cell Cycle Progression in Non-small Cell Lung Cancer via Upregulation of Intracellular Ca Levels.

Biol Pharm Bull 2018 ;41(11):1701-1707

Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University.

Panaxydol, a polyacetylenic compound derived from Panax ginseng has been reported to suppress the growth of cancer cells. However, the molecular mechanisms underlying cell cycle arrest by this compound in non-small cell lung cancer (NSCLC) are unknown. Our study found that panaxydol treatment induced cell cycle arrest at G phase in NSCLC cells. Read More

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January 2018