21,596 results match your criteria Retinoblastoma


Exudative Retinal Detachment Following Intravitreal Chemotherapeutic Treatment for Retinoblastoma.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):248-252

A 35-month-old boy was diagnosed with retinoblastoma and underwent combination intra-arterial (IAC) and intravitreal chemotherapy. His course was complicated by anaphylactic reaction to IAC, yet he continued to improve with sustained intravitreal therapy. Eight months into treatment, the affected eye developed exudative retinal detachment, which resolved with sub-Tenon's steroid administration. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
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http://dx.doi.org/10.3928/23258160-20190401-09DOI Listing
April 2019
4 Reads

Spectrum of mutations in the gene in Vietnamese patients with retinoblastoma.

Mol Vis 2019 4;25:215-221. Epub 2019 Apr 4.

Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Purpose: Retinoblastoma (RB) is a rare childhood malignant disorder caused by the biallelic inactivation of the gene. Early diagnosis and identification of carriers of heritable mutations in can improve disease outcome and management. In this study, we present the spectrum of mutations in the gene in Vietnamese patients with RB. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450663PMC
April 2019
1 Read

LncRNA NKILA inhibits retinoblastoma by downregulating lncRNA XIST.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a Department of Ophthalmology , China-Japan Union Hospital of Jilin University , Changchun , Jilin , 130033 , PR. China.

Purpose: Although retinoblastoma is rare but can be deadly in some severe cases. To find novel therapeutic targets for retinoblastoma, we explored the potential role of lncRNA NKILA in retinoblastoma.

Results: We found that, comparing to healthy controls, NKILA was downregulated, while lncRNA XIST was upregulated in plasma of retinoblastoma patients and they were inversely correlated. Read More

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https://www.tandfonline.com/doi/full/10.1080/02713683.2019.1
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http://dx.doi.org/10.1080/02713683.2019.1606253DOI Listing
April 2019
1 Read

Overexpression of microRNA-186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Strabismus & Pediatric Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, People's Republic of China.

Retinoblastoma (RB) represents an aggressive malignancy in the eye during the period of infancy and childhood. We delineated the ability of microRNA-186 (miR-186) to influence viability, invasion, migration, angiogenesis, and apoptosis of RB via the Hedgehog signaling pathway by targeting AAA domain-containing protein 2 (ATAD2). The microarray-based analysis was adopted to identify differentially expressed genes (DEGs) related to RB. Read More

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http://dx.doi.org/10.1002/jcp.28545DOI Listing

Prevalence of childhood ocular morbidity in a peri-urban setting in Bangladesh: a community-based study.

Public Health 2019 Apr 12;170:103-112. Epub 2019 Apr 12.

National Institute of Ophthalmology and Hospital, Dhaka, Bangladesh. Electronic address:

Objectives: To test a model of integrated pediatric eye care delivery and examine the prevalence and factors associated with childhood ocular morbidity in a peri-urban setting in Bangladesh.

Study Design: Cross-sectional, population-based study.

Methods: The study was conducted in three phases among children aged ≤15 years. Read More

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http://dx.doi.org/10.1016/j.puhe.2019.02.026DOI Listing

Correlation between the protein expression levels of A-kinase anchor protein95, p-retinoblastoma (Ser780), cyclin D2/3, and cyclin E2 in esophageal cancer tissues.

Asia Pac J Clin Oncol 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen Fujian, China.

Aim: This study aimed to investigate the correlation between the expression of A-kinase anchor protein95 (AKAP95), p-retinoblastoma (phosphorylated Rb, p-Rb), cyclin D2, cyclin D3 and cyclin E2 in esophageal cancer tissues and clinicopathological indexes.

Method: The protein expression levels of AKAP95, p-Rb, cyclin D2/3 and cyclin E2 in 40 esophageal cancer tissues were detected using immunohistochemistry, and the correlation between them was analyzed.

Result: The percentage of p-Rb (Ser780)-, cyclin D2-, cyclin D3- and cyclin E2-positive samples was 62. Read More

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http://dx.doi.org/10.1111/ajco.13146DOI Listing
April 2019
1 Read

Potential role of cyclin-dependent kinase 4/6 inhibitors in the treatment of squamous cell carcinoma of the head and neck.

Curr Opin Oncol 2019 May;31(3):122-130

Institut de Recherche Clinique et Expérimentale (Laboratory of Medical Oncology, Pole MIRO), UCLouvain.

Purpose Of Review: Human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN) is mainly driven by genetic aberrations involved in the cell cycle pathway resulting in cyclin-dependent kinase (CDK) 4 and 6 activation. This supports the investigation of the activity of CDK4/6 inhibitors in this disease. We review the therapeutic potential of CDK4/6 inhibitors in SCCHN. Read More

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http://Insights.ovid.com/crossref?an=00001622-201905000-0000
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http://dx.doi.org/10.1097/CCO.0000000000000513DOI Listing
May 2019
2 Reads

Clinical predictors at diagnosis of low risk histopathology in unilateral advanced retinoblastoma.

Ophthalmology 2019 Apr 12. Epub 2019 Apr 12.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Canada; Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. Electronic address:

Objective: Attempted eye salvage for unilateral (cT2b/Group D) retinoblastoma may increase risk of tumor spread compared to primary enucleation. Identification of clinical features predictive of low histopathologic risk would support safe trial salvage.

Design: Retrospective, non-comparative single-institutional observational case series PARTICIPANTS: Children with unilateral cT2b/Group D retinoblastoma (January 2008-February 2018) managed with primary enucleation at the Hospital for Sick Children (SickKids), Toronto, Canada. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.04.003DOI Listing

Outcomes of pediatric retinoblastoma treated with ICEV regimen: A single-center study.

Pediatr Hematol Oncol 2019 Apr 13:1-9. Epub 2019 Apr 13.

a Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand.

Retinoblastoma is the most common intraocular malignancy in children. The aim of this study was to investigate the efficacy and toxicity of combination ifosfamide, carboplatin, etoposide, and vincristine (ICEV) in advanced-stage pediatric retinoblastoma [International Classification of Retinoblastoma (ICRB) group D or E], and in ICRB group C in the second eye in simultaneously treated bilateral retinoblastoma. The medical records of retinoblastoma patients treated with concurrent ICEV regimen and focal therapy were retrospectively reviewed. Read More

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https://www.tandfonline.com/doi/full/10.1080/08880018.2019.1
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http://dx.doi.org/10.1080/08880018.2019.1600083DOI Listing
April 2019
1 Read

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix.

Mol Cell 2019 Apr 5. Epub 2019 Apr 5.

Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address:

The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by phosphorylation. However, the role of Rb phosphorylation by cyclin D-Cdk4,6 in cell-cycle progression is unclear because Rb can be phosphorylated by other cyclin-Cdks, and cyclin D-Cdk4,6 has other targets involved in cell division. Read More

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http://dx.doi.org/10.1016/j.molcel.2019.03.020DOI Listing

ALTERATION OF FACIAL GROWTH AFTER RADIOTHERAPY: ORTHODONTIC, SURGICAL AND PROSTHETIC REHABILITATION.

J Stomatol Oral Maxillofac Surg 2019 Apr 10. Epub 2019 Apr 10.

5 rue Chambovet 69003 Lyon, France.

Most patients treated in childhood with radiotherapy for head and neck tumors develop craniofacial alterations related to impaired growth of the irradiated regions. These deformities have a significant functional and aesthetic impact, generating physiological and social troubles. The therapeutic solutions are mostly surgical and multidisciplinary. Read More

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http://dx.doi.org/10.1016/j.jormas.2019.04.004DOI Listing

Primary Intra-Arterial Chemotherapy for Retinoblastoma in the Intravitreal Chemotherapy Era: Five Years of Experience.

Ocul Oncol Pathol 2019 Feb 21;5(2):139-146. Epub 2018 Aug 21.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: To report our 5-year experience with intra-arterial chemotherapy (IAC) in the intravitreal chemotherapy (IvitC) era.

Methods: Retrospective review of retinoblastoma treated with primary unilateral IAC in the IvitC era (2012-2017).

Results: There were 34 eyes treated with IAC alone versus 20 eyes treated with IAC plus IvitC for vitreous seeds. Read More

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http://dx.doi.org/10.1159/000491580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422129PMC
February 2019

Evidence of Tumour Microenvironment and Stromal Cellular Components in Retinoblastoma.

Ocul Oncol Pathol 2019 Feb 17;5(2):85-93. Epub 2018 Jul 17.

Department of Larsen and Toubro Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Background: The tumour microenvironment (TME) consisting of tumour cells and multiple stromal cell types regulate tumour growth, invasion and metastasis. While the concept of TME and presence of stromal cellular components is widely established in cancers, its significance in the paediatric intraocular malignancy, retinoblastoma (RB), remains unknown.

Methods: The study qualitatively identified the presence of multiple stromal cellular subtypes in RB TME by immunohistochemistry. Read More

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https://www.karger.com/Article/FullText/488709
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http://dx.doi.org/10.1159/000488709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422135PMC
February 2019
9 Reads

p38γ is essential for cell cycle progression and liver tumorigenesis.

Nature 2019 Apr 10. Epub 2019 Apr 10.

Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex. However, control of the G0-to-G1 transition is not completely understood. Here we demonstrate that p38 MAPK gamma (p38γ) acts as a CDK-like kinase and thus cooperates with CDKs, regulating entry into the cell cycle. Read More

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http://www.nature.com/articles/s41586-019-1112-8
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http://dx.doi.org/10.1038/s41586-019-1112-8DOI Listing
April 2019
11 Reads

Synthesis of saporin-antibody conjugates for targeting EpCAM positive tumour cells.

IET Nanobiotechnol 2019 Feb;13(1):90-99

Department of Nanobiotechnology, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, Chennai-600006, India.

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein involved in cell proliferation and differentiation. Ribosomal inactivating proteins derived from plants specifically target ribosomes and irreversibly inhibit protein synthesis. EpCAM antibody and saporin were conjugated using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride/-hydroxysuccinimide chemistry. Read More

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http://mr.crossref.org/iPage?doi=10.1049%2Fiet-nbt.2018.5222
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http://dx.doi.org/10.1049/iet-nbt.2018.5222DOI Listing
February 2019
4 Reads

Simultaneous diagnosis of unilateral retinoblastoma and contralateral optic pathway glioma in a child with neurofibromatosis type 1.

Pediatr Hematol Oncol 2019 Apr 9:1-4. Epub 2019 Apr 9.

e Department of Ophthalmology , The Calcutta Medical Research Institute , Kolkata , India.

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http://dx.doi.org/10.1080/08880018.2019.1591550DOI Listing
April 2019
1 Read

Ponatinib Inhibits Proliferation and Induces Apoptosis of Liver Cancer Cells, but Its Efficacy Is Compromised by Its Activation on PDK1/Akt/mTOR Signaling.

Molecules 2019 Apr 7;24(7). Epub 2019 Apr 7.

Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, Shanxi, China.

Ponatinib is a multi-target protein tyrosine kinase inhibitor, and its effects on hepatocellular carcinoma cells have not been previously explored. In the present study, we investigated its effects on hepatocellular carcinoma cell growth and the underlying mechanisms. Toward SK-Hep-1 and SNU-423 cells, ponatinib induces apoptosis by upregulation of cleaved caspase-3 and -7 and promotes cell cycle arrest in the G1 phase by inhibiting CDK4/6/CyclinD1 complex and phosphorylation of retinoblastoma protein. Read More

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http://dx.doi.org/10.3390/molecules24071363DOI Listing

Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer.

Cells 2019 Apr 6;8(4). Epub 2019 Apr 6.

Department of Internal Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany.

Breast Cancer (BC) is the second most common type of cancer worldwide and displays the highest cancer-related mortality among women worldwide. Targeted therapies have revolutionized the way BC has been treated in recent decades, improving the life expectancies of millions of women. Among the different molecular pathways that have been of interest for the development of targeted therapies are the Cyclin-Dependent Kinases (CDK). Read More

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http://dx.doi.org/10.3390/cells8040321DOI Listing
April 2019
5 Reads

A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration.

Cell 2019 Apr 2. Epub 2019 Apr 2.

Laboratory of Plant Developmental Biology, Wageningen University and Research, 6708 PB Wageningen, the Netherlands; Rijk Zwaan R&D, 4793 RS Fijnaart, the Netherlands. Electronic address:

Plants are sessile and have to cope with environmentally induced damage through modification of growth and defense pathways. How tissue regeneration is triggered in such responses and whether this involves stem cell activation is an open question. The stress hormone jasmonate (JA) plays well-established roles in wounding and defense responses. Read More

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http://dx.doi.org/10.1016/j.cell.2019.03.006DOI Listing
April 2019
1 Read

Frequent and Specific Involvement of Changes of the p16-RB Pathway in Esophageal Neuroendocrine Carcinoma.

Anticancer Res 2019 Apr;39(4):1927-1934

Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo, Japan.

Aim: This study investigated the immunohistochemical expression of retinoblastoma (RB) protein and p16 protein in 10 neuroendocrine carcinomas (NECs), in comparison to two mixed-type NECs; 28 squamous cell carcinomas (SCCs), and 12 carcinosarcomas (CSs) from patients with esophageal cancer.

Materials And Methods: Immunohistochemical staining was performed using the avidin-biotin complex detection method. The staining was evaluated as diffusely positive, heterogeneous (in 5-95% of tumor cells), or diffusely negative. Read More

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http://dx.doi.org/10.21873/anticanres.13302DOI Listing
April 2019
4 Reads

Phase 1 Study Evaluating the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib and Cetuximab in Recurrent/Metastatic p16-Negative Squamous Cell Carcinoma of the Head and Neck.

Front Oncol 2019 19;9:155. Epub 2019 Mar 19.

Departments of Medical Oncology and Head and Neck Surgery, Institut Roi Albert II, Institut de Recherche Clinique et Expérimentale (Pole MIRO), Cliniques Universitaires Saint-Luc, Catholic University of Louvain, Woluwe-Saint-Lambert, Belgium.

The majority of human papillomavirus (HPV)-negative squamous cell carcinoma of the head and neck (SCCHN) present upregulation of the epidermal growth factor receptor (EGFR) and frequent alterations in the cyclin D1-cyclin dependent kinase (CDK) 4/6 (CDK 4/6)-retinoblastoma protein (pRb) pathway, resulting in cell cycle progression and tumor proliferation. This study investigated the combination of ribociclib, an orally highly selective inhibitor of CDK 4/6, and cetuximab in recurrent and/or metastatic (R/M) SCCHN. A phase I trial using a 3 + 3 design was performed to determine the dose limiting toxicity (DLT) and maximum tolerated dose (MTD) of ribociclib with standard dose of weekly cetuximab in HPV-negative patients with R/M SCCHN. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00155/
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http://dx.doi.org/10.3389/fonc.2019.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433958PMC
March 2019
5 Reads

Preventing treatment abandonment for children with solid tumors: A single-center experience in Brazil.

Pediatr Blood Cancer 2019 Apr 2:e27724. Epub 2019 Apr 2.

Clinical Research Division, Brazilian National Cancer Institute, INCA, Brazil.

Background: High rates of treatment abandonment have been considered one of the major limitations to achieving high cure rates of childhood cancer in developing countries. The aims of this study were to report the prevalence and factors associated with treatment abandonment for children diagnosed with solid tumors in one reference center in Brazil and to describe effective strategies to prevent it.

Procedures: A retrospective review was conducted using data from 1139 children (0-18 years) treated for solid tumors at the Brazilian National Cancer Institute, during the period between January 2012 and December 2017. Read More

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http://dx.doi.org/10.1002/pbc.27724DOI Listing

Identification of stemness in primary retinoblastoma cells by analysis of stem-cell phenotypes and tumorigenicity with culture and xenograft models.

Exp Cell Res 2019 Jun 30;379(1):110-118. Epub 2019 Mar 30.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Electronic address:

Retinoblastoma (RB) is a primary intraocular malignancy in childhood, and may develop relapse and metastatic disease. This study was to identify the stem-cell properties of primary retinoblastoma cells critical to tumorigenesis and metastasis. Primary cells were isolated from fresh human RB tissues after enucleation, and cultured in serum-free or serum-enriched conditions, with two RB cell-lines Weri-RB1 and Y79 for comparison. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144827193013
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http://dx.doi.org/10.1016/j.yexcr.2019.03.034DOI Listing
June 2019
9 Reads

Successful Treatment of Relapsed Isolated Extraocular Retinoblastoma in the Right Fibula With High-dose Chemotherapy and Autologous Stem Cell Transplantation.

J Pediatr Hematol Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Paediatric Haematology, Oncology, Blood and Marrow Transplantation, Apollo Cancer Institutes, Chennai, Tamil Nadu, India.

Literature on high-dose chemotherapy followed by autologous stem cell rescue in relapsed retinoblastoma is limited to <150 cases reported so far. We present our experience and the challenges faced in the management of a 7-year-old boy with relapsed isolated extraocular retinoblastoma in the right fibula who received salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell rescue. Electrolyte disturbances, renal tubulopathy, and seizures were the most significant transplant-related morbidity. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001462DOI Listing
March 2019
2 Reads

Demographics of Pediatric Orbital Lesions: A Tertiary Eye Center Experience in Saudi Arabia.

J Epidemiol Glob Health 2019 Mar;9(1):3-10

Department of Diagnostic Radiology, Mansoura Faculty Of Medicine, Egypt.

Orbital lesions vary in their classification, incidence, and presentation depending on the age and geographic distribution. Such lesions in the pediatric age group have been studied extensively because of the possibility of faster progression of orbital involvement and the higher risk of morbidity in this age group in which vision is still developing. In Saudi Arabia, orbital lesions were studied over a 6-year period in the late 1980s, when retinoblastoma cases used to present late with orbital involvement. Read More

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http://dx.doi.org/10.2991/jegh.k.181224.001DOI Listing
March 2019
1 Read

Bilateral advanced (group D or E) intraocular retinoblastoma: outcomes in 72 Asian Indian patients.

Eye (Lond) 2019 Apr 1. Epub 2019 Apr 1.

Operation Eyesight Universal Institute for Eye Cancer, Hyderabad, India.

Purpose: To study the clinical presentation, treatment, and outcomes of patients with bilateral advanced intraocular retinoblastoma.

Methods: Retrospective case series of 72 patients.

Results: The mean age at presentation was 19 months. Read More

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http://dx.doi.org/10.1038/s41433-019-0409-zDOI Listing

Effectiveness of alternative routes of intra-arterial chemotherapy administration for retinoblastoma: Potential for response and complications.

Interv Neuroradiol 2019 Mar 31:1591019919831953. Epub 2019 Mar 31.

4 Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

Objective: Intra-arterial chemotherapy (IAC) is now the first line treatment for selected patients with retinoblastoma (Rb). Typically, IAC is infused following the selective catheterization of the ophthalmic artery (OA) on the affected side. However, in some patients, the OA alone may not provide vascular supply to the tumor, whereas in other instances the efficacy of IAC could be compromised due to the presence of prominent collateral vessels from the external carotid artery (ECA). Read More

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http://dx.doi.org/10.1177/1591019919831953DOI Listing

Cell cycle control by the target of rapamycin signalling pathway in plants.

J Exp Bot 2019 Apr;70(8):2275-2284

School of Biological Sciences, Bourne Laboratory. Royal Holloway, University of London, Egham, Surrey, UK.

Cells need to ensure a sufficient nutrient and energy supply before committing to proliferate. In response to positive mitogenic signals, such as light, sugar availability, and hormones, the target of rapamycin (TOR) signalling pathway promotes cell growth that connects to the entry and passage through the cell division cycle via multiple signalling mechanisms. Here, we summarize current understanding of cell cycle regulation by the RBR-E2F regulatory hub and the DREAM-like complexes, and highlight possible functional relationships between these regulators and TOR signalling. Read More

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http://dx.doi.org/10.1093/jxb/erz140DOI Listing

Reduction of circular RNA expression associated with human retinoblastoma.

Exp Eye Res 2019 Mar 24. Epub 2019 Mar 24.

Department of Ophthalmology, Xinhua Hospital, Medical School, Shanghai Jiao Tong University, 1665 Kong Jiang Road, Shanghai, 200092, China. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2019.03.017DOI Listing
March 2019
1 Read

Spindle Cell Predominant Trichodiscoma or Spindle Cell Lipoma With Adnexal Induction? A Study of 25 Cases, Revealing a Subset of Cases With RB1 Heterozygous Deletion in the Spindle Cell Stroma.

Am J Dermatopathol 2019 Mar 11. Epub 2019 Mar 11.

Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.

In our routine and consultative pathology practices, we have noticed that a relatively high proportion of spindle cell predominant trichodiscomas demonstrate a remarkable stromal admixture of adipose tissue, which along with spindle cells, prominent collagen bundles and myxoid change closely resembles spindle cell lipoma (SCL). To clarify their possible relationship to SCL, 25 cases of trichodiscoma and fibrofolliculoma with stromal "lipomatous metaplasia" were collected and examined using immunohistochemical stains [CD34 and retinoblastoma-1 (RB1) protein] and fluorescence in situ hybridization (RB1 deletion). The patients ranged in age from 35 to 81 years (median 64 years). Read More

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http://dx.doi.org/10.1097/DAD.0000000000001358DOI Listing
March 2019
1 Read

Retinoblastoma: What is the future?

Authors:
Arun D Singh

Int Ophthalmol Clin 2019 ;59(2):95-99

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http://dx.doi.org/10.1097/IIO.0000000000000267DOI Listing
January 2019

Challenges, Opportunities, and Priorities for Advancing Breast Cancer Control in Zambia: A Consultative Meeting on Breast Cancer Control.

J Glob Oncol 2019 Mar;5:1-7

6 University of Texas, MD Anderson Cancer Center, Houston, TX.

In 2016, the Zambian government made cancer control a national priority and released a National Cancer Control Strategic Plan for 2016 to 2021, which focuses on malignancies of the breast, cervix, and prostate, and retinoblastoma. The plan calls for a collective reduction in the cancer burden by 50%. In support of this vision, Susan G. Read More

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http://dx.doi.org/10.1200/JGO.18.00222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449071PMC
March 2019
1 Read

Spontaneous Regression of Florid Retinal Neovascularization Following Resolution of Traction Retinal Detachment in an Eye With Treated Retinoblastoma.

J Pediatr Ophthalmol Strabismus 2019 Mar 25;56:e24-e27. Epub 2019 Mar 25.

A 19-month-old boy with unilateral retinoblastoma with iris and retinal neovascularization at initial presentation displayed traction retinal detachment, retinal non-perfusion, and persistent retinal neovascularization after completion of intra-arterial chemotherapy. Two months following resolution of traction retinal detachment, restoration of retinal perfusion and regression of neovascularization occurred without additional intervention. Spontaneous regression of retinal neovascularization is possible following resolution of traction retinal detachment. Read More

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http://dx.doi.org/10.3928/01913913-20190219-01DOI Listing

E2F1 transactivates IQGAP3 and promotes proliferation of hepatocellular carcinoma cells through IQGAP3-mediated PKC-alpha activation.

Am J Cancer Res 2019 1;9(2):285-299. Epub 2019 Feb 1.

Central Laboratory, Sanmen People's Hospital of Zhejiang Sanmen, China.

For decades, E2F1 has been recognized as a retinoblastoma protein (RB) binding transcription factor that regulates the cell cycle. E2F1 binds preferentially to RB and accelerates the cell cycle in most cancer cells. However, it is thought that E2F1 modulates cell proliferation in other ways as well. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405983PMC
February 2019

Long Noncoding RNA LINC00202 Promotes Tumor Progression by Sponging miR-3619-5p in Retinoblastoma.

Cell Struct Funct 2019 ;44(1):51-60

Department of Ophthalmology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University.

Retinoblastoma (RB) is the most common intraocular malignancy in childhood, and the prognosis in the advanced RB is poor. It is urgent to find novel therapeutic targets. Long noncoding RNAs (lncRNAs) have critical functions in cancer progression, and lncRNA LINC00202 is found associated with poor prognosis in RB. Read More

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http://dx.doi.org/10.1247/csf.18033DOI Listing
January 2019

Management of retinal detachment in retinoblastoma with globe conserving treatment.

J Curr Ophthalmol 2019 Mar 22;31(1):43-48. Epub 2018 Sep 22.

Birmingham and Midland Eye Centre, Birmingham, United Kingdom.

Purpose: To investigate the features and outcomes of retinoblastoma (Rb) patients complicated by development of retinal detachment (RD) following systemic chemotherapy with or without local focal consolidation treatment and without external beam radiotherapy (EBRT).

Methods: A retrospective study of all Rb patients between April 2002 and April 2012 at a tertiary hospital center (Birmingham Children's Hospital and Birmingham Midlands Eye Centre, United Kingdom). All eyes that had developed RD during or after systemic treatment with or without local focal consolidation treatment were included in the study. Read More

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http://dx.doi.org/10.1016/j.joco.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407070PMC
March 2019
6 Reads

Reprogramming of CaCo2 colorectal cancer cells after using the complex of poly-(N-vinylpyrrolidone) with small non-coding RNAs.

Toxicol Rep 2019 15;6:186-192. Epub 2019 Feb 15.

Department of Biomaterials, D.I. Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow, 125047, Russia.

Small non-coding RNAs control normal development and differentiation in the embryo. These regulatory molecules play a key role in the development of human diseases and are used often today for researching new treatments for different pathologies. In this study, CaCo2 colorectal adenocarcinoma cells were initially epigenetically reprogrammed and transformed into CD4+ cells with nano-sized complexes of amphiphilic poly-(N-vinylpyrrolidone) () with miRNA-152 and piRNA-30074. Read More

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http://dx.doi.org/10.1016/j.toxrep.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405903PMC
February 2019

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.

Nat Commun 2019 03 21;10(1):1296. Epub 2019 Mar 21.

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29425, USA.

The dysregulation of Fbxo4-cyclin D1 axis occurs at high frequency in esophageal squamous cell carcinoma (ESCC), where it promotes ESCC development and progression. However, defining a therapeutic vulnerability that results from this dysregulation has remained elusive. Here we demonstrate that Rb and mTORC1 contribute to Gln-addiction upon the dysregulation of the Fbxo4-cyclin D1 axis, which leads to the reprogramming of cellular metabolism. Read More

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http://dx.doi.org/10.1038/s41467-019-09179-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428878PMC

Safety and efficacy profile of cyclin-dependent kinases 4/6 inhibitor palbociclib in cancer therapy: A meta-analysis of clinical trials.

Cancer Med 2019 Mar 21. Epub 2019 Mar 21.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Background: Palbociclib is a small-molecule, cyclin-dependent kinase 4 and 6 inhibitor, which prevents phosphorylation of the retinoblastoma (Rb) protein and inhibits cell-cycle progression from G1 to S phase. We performed this meta-analysis to estimate the safety and efficacy of palbociclib in cancer patients from clinical trials.

Methods: PubMed and EMBASE were searched for eligible studies. Read More

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http://dx.doi.org/10.1002/cam4.1970DOI Listing
March 2019
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microRNA‑485 inhibits the malignant behaviors of retinoblastoma by directly targeting Wnt3a.

Oncol Rep 2019 May 13;41(5):3137-3147. Epub 2019 Mar 13.

Department of Ophthalmology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

Deregulation of microRNAs (miRNAs) has been widely reported in retinoblastoma (RB), and the aberrantly expressed miRNAs may serve as crucial epigenetic regulators in the occurrence and development of RB. Therefore, the identification of dysregulated miRNAs in RB may be useful for the development of effective targets for the therapy patients with this disease. miRNA (miR)‑485‑5p (miR‑485) is deregulated in multiple human cancer types and serves crucial roles in their progression and development. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7061
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http://dx.doi.org/10.3892/or.2019.7061DOI Listing
May 2019
4 Reads

The antitumor function of arctigenin in human retinoblastoma cells is mediated by jagged‑1.

Mol Med Rep 2019 May 14;19(5):3642-3648. Epub 2019 Mar 14.

Department of Ophthalmology, Children's Hospital, Chongqing Medical University, Chongqing 400014, P.R. China.

Retinoblastoma is an intraocular malignant tumor that may severely affect vision and represents a life‑threatening disease in children. Arctigenin (ATG) is an active compound that exhibits numerous pharmacological activities, which is isolated from the seeds of greater burdock (Arctium lappa Linnaeus), a plant used in traditional Chinese herbal medicine. The present study aimed to investigate the effects of ATG on cancer progression by analyzing the retinoblastoma cell line Y79. Read More

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http://dx.doi.org/10.3892/mmr.2019.10026DOI Listing
May 2019
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PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis.

Proc Natl Acad Sci U S A 2019 Apr 20;116(14):7033-7042. Epub 2019 Mar 20.

Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;

High-risk human papillomavirus (HPV) E7 proteins enable oncogenic transformation of HPV-infected cells by inactivating host cellular proteins. High-risk but not low-risk HPV E7 target PTPN14 for proteolytic degradation, suggesting that PTPN14 degradation may be related to their oncogenic activity. HPV infects human keratinocytes but the role of PTPN14 in keratinocytes and the consequences of PTPN14 degradation are unknown. Read More

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http://dx.doi.org/10.1073/pnas.1819534116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452706PMC
April 2019
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Retinoblastoma Incidence Trends in Canada: A National Comprehensive Population-Based Study.

J Pediatr Ophthalmol Strabismus 2019 Mar;56(2):124-130

Purpose: To determine the incidence rates and geographic distribution of retinoblastoma in Canada to aid cancer control programs.

Methods: Patients with retinoblastoma whose data were available from the Canadian Cancer Registry (CCR) and Le Registre Québécois du Cancer (LRQC) were studied. Using third edition International Classification of Diseases for Oncology (ICD-O) codes, the authors examined the incidence rates and geographic distribution of patients with retinoblastoma between 1992 and 2010. Read More

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http://dx.doi.org/10.3928/01913913-20190128-02DOI Listing

Endoresection utilizing pars plana vitrectomy for benign and malignant intraocular tumors.

Curr Opin Ophthalmol 2019 May;30(3):151-158

Tennessee Retina, Nashville, TN, USA.

Purpose Of Review: Endoresection of intraocular tumors is a complicated procedure utilizing pars plana vitrectomy techniques. Though it has potential downsides and complications, there is potential for this technique in the treatment of malignant and benign intraocular tumors.

Recent Findings: Endoresection has been utilized in some form for the last three decades, but recent advances in vitreoretinal surgery have improved the technique. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000561DOI Listing
May 2019
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Prevalence of refractive errors in children with retinoblastoma.

Clin Ophthalmol 2019 25;13:431-435. Epub 2019 Feb 25.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, FL, USA,

Purpose: The main purpose of this study was to investigate refractive errors in children with unilateral and bilateral retinoblastoma (RB).

Methods: An institutional review board-approved consecutive retrospective cohort study was undertaken. Subjects underwent examination under general anesthesia as part of their RB follow-up, which included evaluation by a single pediatric ophthalmologist. Read More

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http://dx.doi.org/10.2147/OPTH.S195145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394233PMC
February 2019