21,504 results match your criteria Retinoblastoma


Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.

Biomed Pharmacother 2019 Feb 18;112:108602. Epub 2019 Feb 18.

Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China; Department of Radiation Oncology and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China. Electronic address:

Cervical cancer remains one of the main factors leading to tumor-related death worldwide. Many strategies of cancer treatment such as chemotherapy are developed and used nowadays. However, for the cancer chemotherapy resistance, reduction of the limitation of cancer chemotherapy efficacy is one of the aims of several oncology teams. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108602DOI Listing
February 2019

Retinoblastoma 1 (RB1) modulates the proliferation of chicken preadipocytes.

Br Poult Sci 2019 Feb 20. Epub 2019 Feb 20.

a Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province; College of Animal Science and Technology , Northeast Agricultural University , Harbin 150030 , P. R. China .

1. The objective of this study was to reveal the role of chicken RB1 (Gallus gallus RB1, gRB1) in the proliferation of preadipocytes. 2. Read More

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https://www.tandfonline.com/doi/full/10.1080/00071668.2019.1
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http://dx.doi.org/10.1080/00071668.2019.1584792DOI Listing
February 2019
1 Read

Cyclins B1, T1 and H differ in their molecular mode of interaction with cytomegalovirus protein kinase pUL97.

J Biol Chem 2019 Feb 19. Epub 2019 Feb 19.

Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany, Germany.

Human cytomegalovirus (HCMV) is a common b-herpesvirus causing life-long, latent infections. HCMV replication interferes with cell cycle regulation in host cells because the HCMV-encoded cyclin-dependent kinase (CDK) ortholog pUL97 extensively phosphorylates the checkpoint regulator retinoblastoma protein. pUL97 also interacts with cyclins B1, T1 and H and recent findings have strongly suggested that these interactions influence pUL97 substrate recognition. Read More

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http://dx.doi.org/10.1074/jbc.RA118.007049DOI Listing
February 2019

Retinoblastoma discordance in families with twins.

Indian J Ophthalmol 2019 Mar;67(3):436-439

Department of Molecular Genetics, Aravind Medical Research Foundation, Madurai, India.

Retinoblastoma has an increased inheritance risk of germline RB1 mutations in offspring and siblings, especially twins. Three families, each having one retinoblastoma-affected twin, were selected for genetic analysis and DNA profiling. Germline RB1 mutations were found in all probands. Read More

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http://www.ijo.in/text.asp?2019/67/3/436/252402
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http://dx.doi.org/10.4103/ijo.IJO_1245_18DOI Listing
March 2019
1 Read

Curious case of retrolental mass: An unusual tele-screening artifact.

Indian J Ophthalmol 2019 Mar;67(3):415-416

Department of Paediatric Retina and Ocular Oncology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.

We are presenting a case of premature baby born at 32 weeks of gestation who was under regular follow-up with our retinopathy of prematurity (ROP) tele-screening team. During final follow-up at 41 weeks of postconceptional age, anterior segment image captured with RetCam showed a retrolental mass lesion in right eye resembling retinoblastoma or medulloepithelioma. The baby was referred to our base hospital for further evaluation, where a detailed examination showed no retrolental lesion or intraocular mass. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1318_18DOI Listing

[Magnetic Resonance Imaging of the Orbital Cavity: Indications and Diagnostic Possibilities].

Klin Monbl Augenheilkd 2019 Feb 18. Epub 2019 Feb 18.

Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated with case-based examples in the context of clinical findings. Vascular pathologies (such as capillary and cavernous hemangioma), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Read More

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http://dx.doi.org/10.1055/a-0849-0000DOI Listing
February 2019

Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma.

J Control Release 2019 Feb 15. Epub 2019 Feb 15.

Departments of Pediatrics, Physiology and Pharmacology, University of Montréal, Montréal, QC, Canada. Electronic address:

Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are short non-coding single-stranded RNAs that affect a vast range of biological processes. Previously, we focused on the regulatory role of miR-181a during cancer development and progression. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.014DOI Listing
February 2019

Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: inhibition of carcinogenesis.

World J Gastroenterol 2019 Feb;25(5):567-583

Regenerative Medicine Laboratory, Faculty of Medicine, Saint-Joseph University, Beirut 1107 2180, Lebanon.

Aim: To investigate the effect of adipose-derived mesenchymal stem cells (ADMSCs) and their conditioned media (CM) on hepatocellular carcinoma (HCC) cell tumorigenesis.

Methods: The proliferation rate of HepG2 and PLC-PRF-5 HCC cancer cells was measured using the trypan blue exclusion method and confirmed using the cell-counting kit 8 (commonly known as CCK-8) assay. Apoptosis was detected by flow cytometry using annexin V-FITC. Read More

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http://dx.doi.org/10.3748/wjg.v25.i5.567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371009PMC
February 2019

Retinoblastoma mutation predicts poor outcomes in advanced non small cell lung cancer.

Cancer Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Hematology and Oncology, Case Western Reserve University, University Hospitals Seidman Cancer Center, Cleveland, Ohio.

The retinoblastoma gene (RB1) encodes the retinoblastoma (RB) pocket protein that plays an important role in cell cycle progression. Here we determine the frequency and prognostic significance of RB1 mutation in non small cell lung cancer (NSCLC), restricting inclusion to Stage III and IV patients with linked genomic and clinical data. The primary outcome was median overall survival (OS). Read More

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http://dx.doi.org/10.1002/cam4.2023DOI Listing
February 2019

PROTACs suppression of CDK4/6, crucial kinases for cell cycle regulation in cancer.

Chem Commun (Camb) 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, Texas A & M University, Box 30012, College Station, TX 77841-3012, USA.

PROTACs based on two selective, FDA approved, CDK4/6 inhibitors were formed. One of them, based on palbociclib, potently initiates degradation of these CDK proteins, and suppresses phosphorylation of retinoblastoma protein (Rb) leading to cell cycle arrest. These PROTACs are active at nanomolar concentrations, and appear to be the first for CDK4/6. Read More

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http://dx.doi.org/10.1039/c9cc00163hDOI Listing
February 2019

MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, Heze Municipal Hospital, Heze, Shandong, China.

Patients with cervical cancer have abnormal cell proliferation and invasion after many years of latency. However, the precise mechanisms remain unclear. Mitogen- and stress-activated kinase 2 (MSK2) is a serine/threonine kinase which displays a phenotype that promotes tumor growth and metastasis in many different types of tumors. Read More

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http://dx.doi.org/10.1002/jcb.28421DOI Listing
February 2019

A semi-automated whole exome sequencing workflow leads to increased diagnostic yield and identification of novel candidate variants.

Cold Spring Harb Mol Case Stud 2019 Feb 12. Epub 2019 Feb 12.

Children's Hospital Los Angeles;

Background: Advancing the clinical utility of whole exome sequencing (WES) for patients with suspected genetic disorders is largely driven by bioinformatics approaches that streamline data processing and analysis.

Methods: Herein, we describe our experience with implementing a semi-automated and phenotype-driven WES diagnostic workflow, incorporating both the DRAGEN pipeline and the Exomiser variant prioritization tool, at an academic children's hospital with an ethnically diverse pediatric patient population.

Results: We achieved a 41% molecular diagnostic rate for 66 duo-, quad- or trio- WES cases, and 28% for 40 singleton-WES cases. Read More

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http://dx.doi.org/10.1101/mcs.a003756DOI Listing
February 2019
1 Read

Non-invasive diagnosis of retinoblastoma using cell-free DNA from aqueous humour.

Br J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

West Midlands Regional Genetics Service, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

Retinoblastoma is the most common eye malignancy in childhood caused by mutations in the gene. Both alleles of the gene must be mutated for tumour development. The initial mutation may be constitutional germline or somatic (originating in one retinal cell only). Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3130
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http://dx.doi.org/10.1136/bjophthalmol-2018-313005DOI Listing
February 2019
1 Read

Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer.

J Gynecol Oncol 2018 Nov 22. Epub 2018 Nov 22.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP inhibitor, has an anti-tumor effect on high grade serous ovarian cancer, but its effects on cellular senescence have not been reported. This study intends to explore the role of olaparib in the regulation of senescence in ovarian cancer cells. Read More

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https://ejgo.org/DOIx.php?id=10.3802/jgo.2019.30.e26
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http://dx.doi.org/10.3802/jgo.2019.30.e26DOI Listing
November 2018
2 Reads

Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells.

Commun Biol 2019 3;2. Epub 2019 Jan 3.

1Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337 Japan.

Mitochondrial damage is caused by changes in the micro-environmental conditions during tumor progression. Cancer cells require mechanisms for mitochondrial quality control during this process; however, how mitochondrial integrity is maintained is unclear. Here we show that E2F3d, a previously unidentified E2F3 isoform, mediates hypoxia-induced mitophagy in cancer cells. Read More

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http://dx.doi.org/10.1038/s42003-018-0246-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318215PMC
January 2019

Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.

J Exp Med 2019 Feb 8. Epub 2019 Feb 8.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY

Cancer models based on cells derived from human embryonic stem cells (hESCs) may reveal why certain constellations of genetic changes drive carcinogenesis in specialized lineages. Here we demonstrate that inhibition of NOTCH signaling induces up to 10% of lung progenitor cells to form pulmonary neuroendocrine cells (PNECs), putative precursors to small cell lung cancers (SCLCs), and we can increase PNECs by reducing levels of retinoblastoma (RB) proteins with inhibitory RNA. Reducing levels of TP53 protein or expressing mutant or genes did not induce or expand PNECs, but tumors resembling early-stage SCLC grew in immunodeficient mice after subcutaneous injection of PNEC-containing cultures in which expression of both and was blocked. Read More

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http://dx.doi.org/10.1084/jem.20181155DOI Listing
February 2019
3 Reads

Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts.

Carbohydr Polym 2019 Apr 28;210:389-398. Epub 2019 Jan 28.

Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina, Universitat de Lleida and Institut de Recerca Biomèdica de Lleida, IRBLleida, Lleida, Catalonia, Spain. Electronic address:

β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. Unexpectedly, we have observed that this compound promoted a short-transitory proliferation arrest at 24 h after its addition on the medium. Read More

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http://dx.doi.org/10.1016/j.carbpol.2019.01.090DOI Listing
April 2019
1 Read

Ginsenoside-Rg5 Inhibits Retinoblastoma Proliferation and Induces Apoptosis through Suppressing BCL2 Expression.

Chemotherapy 2019 Feb 7;63(5):293-300. Epub 2019 Feb 7.

Record Room, Jinan Second People's Hospital, Jinan,

Background/aims: Although the cure rate for retinoblastoma is high, surviving patients are at risk for developing secondary cancers and require life-long follow-up. It is imperative to discover and develop novel therapeutic agents with better efficiency and fewer adverse effects. Ginsenoside-Rg5 is an active derivate from ginseng and exerts anti-cancer activity in breast cancer cells. Read More

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http://dx.doi.org/10.1159/000495575DOI Listing
February 2019

Preclinical characterization of SHR6390, a novel CDK 4/6 inhibitor, in vitro and in human tumor xenograft models.

Cancer Sci 2019 Feb 6. Epub 2019 Feb 6.

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Inhibition of the cyclin-dependent kinase (CDK) 4/6-retinoblastoma (RB) pathway is an effective therapeutic strategy against cancer. Here, we performed a preclinical investigation of the antitumor activity of SHR6390, a novel CDK4/6 inhibitor. SHR6390 exhibited potent antiproliferative activity against a wide range of human RB-positive tumor cells in vitro, and exclusively induced G arrest as well as cellular senescence, with a concomitant reduction in the levels of Ser780-phosphorylated RB protein. Read More

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http://dx.doi.org/10.1111/cas.13957DOI Listing
February 2019
2 Reads

Retinoblastoma with late metastatic spread-a case report.

Pediatr Blood Cancer 2019 Feb 5:e27656. Epub 2019 Feb 5.

Hopp Children's Cancer Center (KiTZ), Heidelberg University Hospital, Heidelberg, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pbc.27656
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http://dx.doi.org/10.1002/pbc.27656DOI Listing
February 2019
3 Reads

MicroRNA‑504 targets AEG‑1 and inhibits cell proliferation and invasion in retinoblastoma.

Mol Med Rep 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

The dysregulation of microRNAs (miRNAs/miRs) has become increasingly recognized as a primary feature of retinoblastoma (RB). Furthermore, miRNAs have been demonstrated to be involved in the occurrence and development of RB. Therefore, it is crucial to investigate the expression profile and roles of miRNAs in RB in order to identify potential therapeutic targets to treat patients with RB. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.9923
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http://dx.doi.org/10.3892/mmr.2019.9923DOI Listing
February 2019
2 Reads

The anthelmintic agent oxfendazole inhibits cell growth in non‑small cell lung cancer by suppressing c‑Src activation.

Mol Med Rep 2019 Jan 28. Epub 2019 Jan 28.

Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

The c‑Src protein family of tyrosine kinases are important in the tumorigenesis of many types of tumors, and may be a potential target for antitumor drug discovery. In the present study, immunoblotting was performed to analyze protein expression, CCK‑8 assay was carried out to assess cell viability and cell cycle was analyzed using a flow cytometer. The anthelmintic agent oxfendazole was observed to be a novel c‑Src inhibitor that blocked the activation of c‑Src. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.9897
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http://dx.doi.org/10.3892/mmr.2019.9897DOI Listing
January 2019
1 Read

2,3,7,8‑tetrachlorodibenzo‑p‑dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling.

Int J Oncol 2019 Jan 30. Epub 2019 Jan 30.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 700 Tiverton Avenue, Los Angeles, CA 90095‑1732, USA.

Human colorectal cancer is the third most common cancer disease with a 5‑year survival rate of 55% in USA in 2016. The investigation to identify novel biomarker factors with molecular classification may provide notable clinical information to prolong the survival of patients with colorectal cancer. The aryl hydrocarbon receptor (AHR) binds the AHR nuclear translocator in the cytoplasm of various types of cells, including liver cells, and then binds to the xenobiotic responsive element on various genes. Read More

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http://dx.doi.org/10.3892/ijo.2019.4703DOI Listing
January 2019

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary.

Nat Commun 2019 Feb 4;10(1):558. Epub 2019 Feb 4.

Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.

Inactivating mutations in SMARCA4 (BRG1), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). To reveal its druggable vulnerabilities, we perform kinase-focused RNAi screens and uncover that SMARCA4-deficient SCCOHT cells are highly sensitive to the inhibition of cyclin-dependent kinase 4/6 (CDK4/6). SMARCA4 loss causes profound downregulation of cyclin D1, which limits CDK4/6 kinase activity in SCCOHT cells and leads to in vitro and in vivo susceptibility to CDK4/6 inhibitors. Read More

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http://dx.doi.org/10.1038/s41467-018-06958-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361890PMC
February 2019
1 Read
10.742 Impact Factor

Intra-Arterial Chemotherapy for Retinoblastoma: 8-Year Experience from a Tertiary Referral Institute in Thailand.

Asia Pac J Ophthalmol (Phila) 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Purpose: To study the safety and efficacy of intra-arterial chemotherapy (IAC) as a treatment for intraocular retinoblastoma in Thailand.

Design: Retrospective, interventional case series.

Methods: In this study, IAC was performed as primary or secondary treatment for patients with intraocular retinoblastoma using melphalan with or without additional topotecan or carboplatin. Read More

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http://dx.doi.org/10.22608/APO.2018294DOI Listing
February 2019
1 Read

Unilateral retinoblastoma in a patient with Hermansky-Pudlak syndrome.

Ophthalmic Genet 2019 Feb 4:1-3. Epub 2019 Feb 4.

b Hamilton Eye Institute, Department of Ophthalmology , University of Tennessee , Memphis , TN , USA.

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http://dx.doi.org/10.1080/13816810.2019.1571618DOI Listing
February 2019

CDK4/6 Inhibitor LEE011 Is a Potential Radiation-sensitizer in Head and Neck Squamous Cell Carcinoma: An Study.

Anticancer Res 2019 Feb;39(2):713-720

Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.

Background: Radiotherapy (RT) combined with a radiosensitizer represents an important treatment for head and neck squamous cell carcinoma (HNSCC). Only few chemotherapy agents are currently approved as radiosensitizers for targeted therapy. In this study, the potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor LEE011 was tested for potential to act as a radiosensitizer during RT. Read More

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http://dx.doi.org/10.21873/anticanres.13167DOI Listing
February 2019

ANRIL acts as onco-lncRNA by regulation of microRNA-24/c-Myc, MEK/ERK and Wnt/β-catenin pathway in retinoblastoma.

Int J Biol Macromol 2019 Jan 28;128:583-592. Epub 2019 Jan 28.

Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China. Electronic address:

Retinoblastoma is the most common intraocular malignant tumor in infants and children with metastatic potential. This study aimed to investigate the effects of antisense non-coding RNA in the INK4 locus (ANRIL) on retinoblastoma cell viability, migration and invasion, as well as the potential downstream molecules and possible signaling pathways. We found that ANRIL was highly expressed in retinoblastoma tissues and cells. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.157DOI Listing
January 2019

Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer.

Oncogene 2019 Jan 30. Epub 2019 Jan 30.

Oncology Translational Research, Pfizer Inc., San Diego, CA, 92121, USA.

The CDK4/6 inhibitor palbociclib reduces tumor growth by decreasing retinoblastoma (RB) protein phosphorylation and inducing cell cycle arrest at the G1/S phase transition. Palbociclib in combination with anti-hormonal therapy brings significant benefit to breast cancer patients. In this study, novel combination approaches and underlying molecular/cellular mechanisms for palbociclib were explored in squamous cell lung cancer (SqCLC), the second most common subtype of non-small cell lung cancer. Read More

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http://dx.doi.org/10.1038/s41388-019-0708-7DOI Listing
January 2019
1 Read

Patterns of Cause-Specific Mortality Among 2053 Survivors of Retinoblastoma, 1914-2016.

J Natl Cancer Inst 2019 Jan 30. Epub 2019 Jan 30.

Background: Previous studies of hereditary retinoblastoma survivors have reported elevated mortality, particularly for sarcomas, compared with the general population. However, cause-specific mortality patterns for long-term hereditary and nonhereditary retinoblastoma survivors are poorly understood.

Methods: Among 2053 retinoblastoma patients diagnosed during 1914-2006 at two major US treatment centers and followed to 2016, we estimated cumulative mortality, standardized mortality ratios (SMRs), and absolute excess risks (AERs) compared with the US general population. Read More

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http://dx.doi.org/10.1093/jnci/djy227DOI Listing
January 2019

The Amazon Ocular Oncology Center: The first three years.

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

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http://dx.doi.org/10.5935/0004-2749.20190024DOI Listing
January 2019
1 Read

Effects of lentivirus-mediated astrocyte elevated gene-1 overexpression on proliferation and apoptosis of human retinoblastoma cells.

Acta Ophthalmol 2019 Jan 29. Epub 2019 Jan 29.

Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Purpose: To investigate the effect of astrocyte elevated gene-1 (AEG-1) overexpression on the biological behaviour of human retinoblastoma (RB) cells and its possible mechanism.

Methods: Three human RB cell lines (SO-RB50, Y79 and WERI-RB1) were infected with AEG-1-GFP recombinant lentiviral vectors to induce AEG-1 overexpression, while the cells infected with negative lentiviral vectors and cells without any intervention formed control groups.

Results: All three RB cell lines showed an overexpression of AEG-1 after lentivirus infection (p < 0. Read More

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http://dx.doi.org/10.1111/aos.14034DOI Listing
January 2019

The impact of monocular vision on motor function and quality of life in survivors of retinoblastoma.

Pediatr Blood Cancer 2019 Jan 28:e27623. Epub 2019 Jan 28.

Department of Pediatric Hematology-Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: Monocular vision has been found to have a negative effect on children's motion processing and motor functions. Yet, knowledge of motor function of survivors of retinoblastoma (RB) with monocular vision (due to enucleation, for example) is limited. This study examined motor function and its relationship to visual-related and health-related quality of life (HRQOL) in survivors of RB with monocular vision. Read More

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http://doi.wiley.com/10.1002/pbc.27623
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http://dx.doi.org/10.1002/pbc.27623DOI Listing
January 2019
2 Reads

Human Papillomavirus Detection Strategies in Retinoblastoma.

Pathol Oncol Res 2019 Jan 26. Epub 2019 Jan 26.

Department of Ocular Pathology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Room no. 725, New Delhi, 110029, India.

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http://dx.doi.org/10.1007/s12253-018-00577-xDOI Listing
January 2019
1 Read

Bisphenol S promotes the cell cycle progression and cell proliferation through ERα-cyclin D-CDK4/6-pRb pathway in MCF-7 breast cancer cells.

Toxicol Appl Pharmacol 2019 Mar 23;366:75-82. Epub 2019 Jan 23.

Marine Life Science College, Ocean University of China, 5 Yushan Road, Qingdao 266003, Shandong province, PR China. Electronic address:

Bisphenol S (BPS), exhibiting estrogenic activity, has been reported to promote cell proliferation in MCF-7 breast cancer cells; however, the underlying mechanism remains unclear. In this study, BPS (1-100 μM) significantly promoted cell proliferation in ERα positive MCF-7 cells, but not in ERα negative MDA-MB-231 or SK-BR-3 cells, confirming the important role of ERα in BPS-induced cell proliferation. Results of the flow cytometry analysis indicated that 10 μM BPS promoted MCF-7 proliferation by accelerating G to S phase transition of the cell cycle. Read More

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http://dx.doi.org/10.1016/j.taap.2019.01.017DOI Listing

The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways.

Cell Mol Life Sci 2019 Jan 25. Epub 2019 Jan 25.

Université Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75, 1200, Brussels, Belgium.

HMG box protein 1 (HBP1) is a transcription factor and a potent cell cycle inhibitor in normal and cancer cells. HBP1 activates or represses the expression of different cell cycle genes (such as CDKN2A, CDKN1A, and CCND1) through direct DNA binding, cofactor recruitment, chromatin remodeling, or neutralization of other transcription factors. Among these are LEF1, TCF4, and MYC in the WNT/beta-catenin pathway. Read More

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http://dx.doi.org/10.1007/s00018-019-03012-9DOI Listing
January 2019
4 Reads

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer.

Oncotarget 2018 Dec 3;9(101):37471-37479. Epub 2018 Jan 3.

Department of General Surgery, Yixing People's Hospital The Affiliated Hospital of Jiangsu University, Yixing 214200, Jiangsu, P.R China.

Recent studies revealed that several Long noncoding RNAs (LncRNAs) are associated with progression of gastric cancer (GC), while the functional role and molecular mechanism of many GC-associated lncRNAs remain undetermined. The tumor suppressor-gene retinoblastoma gene (RB1) was decreased in several human cancers including gastric cancer (GC). In this study, we investigated whether Linc00441 was involved in the suppression of RB1. Read More

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http://dx.doi.org/10.18632/oncotarget.23928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331029PMC
December 2018

MicroRNA-361-3p regulates retinoblastoma cell proliferation and stemness by targeting hedgehog signaling.

Authors:
Dan Zhao Zhe Cui

Exp Ther Med 2019 Feb 6;17(2):1154-1162. Epub 2018 Dec 6.

Department of Ophthalmology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China.

Retinoblastoma (RB) is the most common type of intraocular malignancy in children. During RB oncogenesis, sonic hedgehog (SHH) is commonly differentially expressed. Additionally, microRNAs (miRs) are known to serve crucial roles as oncogenes or tumor suppressors. Read More

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http://www.spandidos-publications.com/10.3892/etm.2018.7062
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http://dx.doi.org/10.3892/etm.2018.7062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327618PMC
February 2019
3 Reads

Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate.

PLoS One 2019 24;14(1):e0211153. Epub 2019 Jan 24.

Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, California, United States of America.

The tumor suppressor p16Ink4a, encoded by the INK4a gene, is an inhibitor of cyclin D-dependent kinases 4 and 6, CDK4 and CDK6. This inhibition prevents the phosphorylation of the retinoblastoma protein (pRb), resulting in cellular senescence through inhibition of E2F-mediated transcription of S phase genes required for cell proliferation. The p16Ink4a plays an important role in tumor suppression, whereby its deletion, mutation, or epigenetic silencing is a frequently observed genetic alteration in prostate cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211153PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345450PMC
January 2019
4 Reads

Regional Anesthesia for Pediatric Ophthalmic Surgery: A Review of the Literature.

Anesth Analg 2019 Jan 21. Epub 2019 Jan 21.

Department of Anesthesiology, Perioperative Medicine and Pain Management, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami Health System, Miami, Florida.

Ophthalmic pediatric regional anesthesia has been widely described, but infrequently used. This review summarizes the available evidence supporting the use of conduction anesthesia in pediatric ophthalmic surgery. Key anatomic differences in axial length, intraocular pressure, and available orbital space between young children and adults impact conduct of ophthalmic regional anesthesia. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004012DOI Listing
January 2019
12 Reads

The University of California, San Francisco Documentation System for Retinoblastoma: Preparing to Improve Staging Methods for This Disease.

Ocul Oncol Pathol 2019 Jan 14;5(1):36-45. Epub 2018 Jun 14.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.

Background/aims: Current retinoblastoma staging systems do not adequately describe the disease, especially in eyes with multiple tumors. The aims of this study were to develop methods for documenting individual tumors and to score disease burden over time.

Methods: A coding system was devised to describe each tumor according to affected eye, meridian, anteroposterior location, activity, growth pattern, type of seed, and treatment. Read More

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https://www.karger.com/Article/FullText/488147
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http://dx.doi.org/10.1159/000488147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341334PMC
January 2019
4 Reads

The Incidence of Binocular Visual Impairment and Blindness in Children with Bilateral Retinoblastoma.

Ocul Oncol Pathol 2019 Jan 19;5(1):1-7. Epub 2018 Jun 19.

The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom.

Purpose: The study aimed to assess the incidence of and risk factors leading to visual impairment and legal blindness in children with retinoblastoma.

Procedures: This is a single-center, retrospective case series of all patients with bilateral retinoblastoma presenting from 2010 to 2014.

Results: A total of 44 patients were included in the study. Read More

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http://dx.doi.org/10.1159/000489313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341332PMC
January 2019
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Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01.

Sci Transl Med 2019 Jan;11(476)

Institut de Recerca Sant Joan de Deu, Barcelona 08950, Spain.

Retinoblastoma is a pediatric solid tumor of the retina activated upon homozygous inactivation of the tumor suppressor VCN-01 is an oncolytic adenovirus designed to replicate selectively in tumor cells with high abundance of free E2F-1, a consequence of a dysfunctional RB1 pathway. Thus, we reasoned that VCN-01 could provide targeted therapeutic activity against even chemoresistant retinoblastoma. In vitro, VCN-01 effectively killed patient-derived retinoblastoma models. Read More

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http://dx.doi.org/10.1126/scitranslmed.aat9321DOI Listing
January 2019
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Crocin inhibits proliferation and induces apoptosis through suppressing MYCN expression in retinoblastoma.

J Biochem Mol Toxicol 2019 Jan 23:e22292. Epub 2019 Jan 23.

Department of TCM Ophthalmology, Jinan Second People's Hospital, Jinan, Shandong, China.

The pathogenetic mechanisms of retinoblastoma are still not yet fully elucidated, putting limits to efficacious treatment. Crocin is the main component of saffron, which exhibits significant antitumorigenic properties. The aim of this paper is to investigate the effect of crocin on retinoblastoma. Read More

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http://dx.doi.org/10.1002/jbt.22292DOI Listing
January 2019

Resonance assignments for the tandem PWWP-ARID domains of human RBBP1.

Biomol NMR Assign 2019 Jan 21. Epub 2019 Jan 21.

Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.

Retinoblastoma-binding protein 1 (RBBP1), also known as AT-rich interaction domain 4A (ARID4A), is a tumour suppressor involved in the regulation of the epigenetic programming in leukemia and Prader-Willi/Angelman syndromes. The ARID domain of RBBP1 binds to DNA non-specifically and has gene suppression activity. However, no structural data has been obtained for the human RBBP1 ARID domain so far. Read More

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http://dx.doi.org/10.1007/s12104-019-09873-2DOI Listing
January 2019

MicroRNA‑98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k‑Ras/Raf/MEK/ERK signaling pathway.

Int J Oncol 2019 Mar 17;54(3):807-820. Epub 2019 Jan 17.

Department of Ophthalmology, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, P.R. China.

Accumulating evidence has indicated that the dysregulation of microRNAs (miRNAs) is involved in the pathogenesis o retinoblastoma (RB); however, the potential role of miR‑98 in RB remains elusive. In the present study, it was demonstrated that miR‑98 is downregulated in RB tissues and cell lines, and its expression significantly associated with clinicopathological features, including differentiation, N classification and largest tumor base; patients with low miR‑98 expression levels exhibited significantly poorer overall survival. Overexpression of miR‑98 was suggested to suppress RB cell growth, migration and invasion. Read More

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http://dx.doi.org/10.3892/ijo.2019.4689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365030PMC

A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach.

Am J Cancer Res 2018 1;8(12):2359-2376. Epub 2018 Dec 1.

Department of Molecular and Experimental Medicine, Avera Cancer Institute Sioux Falls, SD, USA.

Cyclin-dependent kinase 4 (CDK4) and CDK6 together with D-type cyclins (D1, D2 and D3) to promote cell cycle entry and progression through G1 by inactivating retinoblastoma protein (RB) by inhibiting an INK4 family of CDK inhibitors (CDKN2A/B). Selective cyclin-dependent kinase inhibitors are game changers in the clinical management of hormone receptor-positive/HER2-negative advanced breast cancers. There are currently three CDK4/6 inhibitors that have been approved by the US Food and Drug administration: palbociclib, ribociclib, and abemaciclib. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325472PMC
December 2018
4 Reads

Perioperative Care of Children Undergoing Intra-arterial Chemotherapy for Retinoblastoma.

J Perianesth Nurs 2019 Jan 16. Epub 2019 Jan 16.

Retinoblastoma (RB) is a rare cancer of the eye, most commonly seen in children. Intra-arterial chemotherapy for RB is a relatively new treatment modality that has gained increasing popularity worldwide. The principal underlying the intra-arterial approach is delivery of chemotherapeutic agents directly to the site of the tumor. Read More

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http://dx.doi.org/10.1016/j.jopan.2018.09.013DOI Listing
January 2019

Drug Repurposing for Retinoblastoma: Recent Advances.

Curr Top Med Chem 2019 Jan 19. Epub 2019 Jan 19.

CSIR- Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad 500 007. India.

Retinoblastoma is the intraocular malignancy that occurs during early childhood. The current standard of care includes chemotherapy followed by focal consolidative therapies, and enucleation. Unfortunately, these are associated with many side and late effects. Read More

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http://www.eurekaselect.com/169178/article
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http://dx.doi.org/10.2174/1568026619666190119152706DOI Listing
January 2019
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Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports.

Mol Clin Oncol 2019 Jan 26;10(1):153-158. Epub 2018 Oct 26.

Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.

The prognosis of childhood cancers has improved markedly, and the proportion of long-term survivors has increased in recent years. However, with the increase in the number of long-term survivors, the development of latent treatment-related adverse effects, such as secondary malignancies, has generated new problems. Secondary cancer is defined as a histologically distinct malignancy that develops at least 2 months after the completion of treatment for primary cancer. Read More

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http://dx.doi.org/10.3892/mco.2018.1752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313944PMC
January 2019