2,884 results match your criteria Retinitis CMV


Monitoring of cytomegalovirus infection in non-transplant pediatric acute lymphoblastic leukemia patients during chemotherapy.

Medicine (Baltimore) 2019 Jan;98(4):e14256

Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, Thailand.

Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality in the posttransplant setting; however, it is increasingly recognized in pediatric leukemia during chemotherapy. This study assessed the prevalence and associated factors of CMV infection in pediatric non-transplant leukemia patients.This was a cross-sectional study of 50 pediatric acute lymphoblastic leukemia (ALL) patients receiving chemotherapy at Ramathibodi Hospital from December 2015 to December 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000014256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358396PMC
January 2019
3 Reads

CD4+ cells as a potential biomarker for cytomegalovirus retinitis in children with acute lymphocytic leukemia.

Chin Med J (Engl) 2019 Feb;132(3):356-359

Department of Hematology, Hebei Children's Hospital, Hebei Medical University, Shijiazhuang, Hebei 050031, China.

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http://dx.doi.org/10.1097/CM9.0000000000000065DOI Listing
February 2019
1 Read

Adult T-Cell Leukemia/Lymphoma-Related Ocular Manifestations: Analysis of the First Large-Scale Nationwide Survey.

Front Microbiol 2018 8;9:3240. Epub 2019 Jan 8.

Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Adult T-cell leukemia/lymphoma (ATL) is a rare and aggressive T-cell malignancy with a high mortality rate, resulting in a lack of information among ophthalmologists. Here, we investigated the state of ophthalmic medical care for ATL and ATL-related ocular manifestations by conducting the first large-scale nationwide survey in Japan. A total of 115 facilities were surveyed, including all university hospitals in Japan that were members of the Japanese Ophthalmological Society and regional core facilities that were members of the Japanese Ocular Inflammation Society. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331419PMC
January 2019

Use of Letermovir as Salvage Therapy for Drug-resistant CMV Retinitis: A Case Series.

Antimicrob Agents Chemother 2019 Jan 14. Epub 2019 Jan 14.

Duke University School of Medicine, Division of Infectious Diseases, Durham, NC

Treatment options for drug-resistant CMV are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but efficacy in other settings is unknown. We recently used letermovir for salvage treatment in four solid organ transplant recipients with ganciclovir-resistant CMV retinitis. Read More

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http://dx.doi.org/10.1128/AAC.02337-18DOI Listing
January 2019
1 Read

: ophthalmic complications following lung transplantation.

J Thorac Dis 2018 Nov;10(11):6285-6297

Respiratory Institute, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Ophthalmic complications in the lung transplant population are a little-known entity. It includes a spectrum of diseases ranging from infections such as cytomegalovirus (CMV) retinitis, herpetic keratitis, to non-infectious complications such as posterior subcapsular cataracts (PSCs), cyclosporine retinopathy, and post-transplant lymphoproliferative disorder (PTLD). These diseases can be attributed to high levels of immunosuppression, advanced age, and drug-specific side effects. Read More

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http://jtd.amegroups.com/article/view/24861/19111
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http://dx.doi.org/10.21037/jtd.2018.09.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297435PMC
November 2018
4 Reads

RETINAL FINDINGS IN PRESUMED INFECTIOUS POSTERIOR UVEITIS AND CORRELATION WITH POLYMERASE CHAIN REACTION RESULTS.

Retina 2018 Dec 27. Epub 2018 Dec 27.

Department of Ophthalmology, the Icahn School of Medicine at Mount Sinai, New York, New York.

Purpose: To correlate demographics, retinal lesion characteristics, and host immune status with the pathogen found on polymerase chain reaction analysis of aqueous fluid in patients with suspected infectious posterior uveitis.

Methods: Medical records of patients who underwent anterior chamber paracentesis for suspected infectious posterior uveitis and had retinal photographs between 2014 and 2016 at a single institution were reviewed. Data collection included demographics, clinical appearance of the lesions, and polymerase chain reaction results. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002423DOI Listing
December 2018
2 Reads

Successively bilateral cytomegalovirus retinitis in immunocompromised patient with Good's syndrome.

Int J Ophthalmol 2018 18;11(12):2021-2023. Epub 2018 Dec 18.

Beijing Institute of Ophthalmology, Beijing 100005, China.

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http://dx.doi.org/10.18240/ijo.2018.12.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288527PMC
December 2018
1 Read

Initial intravitreal injection of high-dose ganciclovir for cytomegalovirus retinitis in HIV-negative patients.

BMC Ophthalmol 2018 Dec 10;18(1):314. Epub 2018 Dec 10.

Shanghai Aier Eye Hospital, Shanghai, China, No. 1286, Hongqiao Road, Changning District, Shanghai, 200050, China.

Background: The purpose of this study is to examine the clinical outcomes achieved by using initial high-dose intravitreal ganciclovir injections to treat cytomegalovirus retinitis in patients without human immunodeficiency virus (HIV) infection.

Methods: Twenty-four eyes (24 patients) with cytomegalovirus retinitis received multiple intravitreal injections of ganciclovir in weekly intervals. A higher dose (6 mg) of ganciclovir was applied at the first intravitreal injection, and a lower dose was used for maintenance. Read More

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http://dx.doi.org/10.1186/s12886-018-0983-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288921PMC
December 2018
2 Reads

Burden of cytomegalovirus reactivation post kidney transplant with antithymocyte globulin use in Thailand: A retrospective cohort study.

F1000Res 2018 28;7:1568. Epub 2018 Sep 28.

Division of Infectious disease, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.

Cytomegalovirus (CMV) is an important cause of infectious complications after kidney transplantation (KT), especially among patients receiving antithymocyte globulin (ATG). CMV infection can result in organ dysfunction and indirect effects such as graft rejection, graft failure, and opportunistic infections Prevention of CMV reactivation includes pre-emptive or prophylactic approaches. Access to valganciclovir prophylaxis is limited by high cost. Read More

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https://f1000research.com/articles/7-1568/v1
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http://dx.doi.org/10.12688/f1000research.16321.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234719PMC
September 2018
12 Reads

Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt's lymphoma and Kaposi's sarcoma.

BMC Cancer 2018 Nov 8;18(1):1080. Epub 2018 Nov 8.

Department of Infectious Diseases, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, Korea.

Background: The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who are severely immunosuppressed or have incomplete virologic suppression.

Case Presentation: We report a case of dual primary ADCs, especially NHL followed by KS, in a 70-year-old HIV-infected man who was on antiretroviral therapy and had successful virologic suppression. Read More

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http://dx.doi.org/10.1186/s12885-018-5019-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225729PMC
November 2018
10 Reads

Spectrum of Newly Diagnosed Cytomegalovirus Retinitis in a Developing Country in the HAART Era.

Ocul Immunol Inflamm 2018 Nov 5:1-7. Epub 2018 Nov 5.

a Advanced Eye Centre, Department of Ophthalmology , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: To characterize the presenting features of cytomegalovirus (CMV) retinitis in HIV-positive patients in a developing country in the HAART era.

Methods: Retrospective chart review of all patients with CMV retinitis seen at a tertiary-care referral center between January 2006 to June 2017. Demographic and clinical data were collected to study the presenting features and risk factors for blindness. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
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http://dx.doi.org/10.1080/09273948.2018.1538460DOI Listing
November 2018
11 Reads
1.440 Impact Factor

Comparison of intravitreal ganciclovir monotherapy and combination with foscarnet as initial therapy for cytomegalovirus retinitis.

Int J Ophthalmol 2018 18;11(10):1638-1642. Epub 2018 Oct 18.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 11217, Taiwan, China.

Aim: To compare the effectiveness between multiple intravitreal injections of ganciclovir alone and combined with foscarnet as initial treatment for patients with newly-onset cytomegalovirus retinitis (CMVR).

Methods: The retrospective study observed 37 patients (58 eyes) who suffered from CMVR onset between 2013 and 2015. Among them, 35 eyes underwent 4 weekly intravitreal injections of 3. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.10.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192958PMC
October 2018
6 Reads
0.500 Impact Factor

Cytomegalovirus Retinitis in Primary Immune Deficiency Disease.

Case Rep Ophthalmol Med 2018 19;2018:8125806. Epub 2018 Sep 19.

Department of Ophthalmology, Hospital Shah Alam, Selangor, Malaysia.

Introduction: To report an unusual case of CMV retinitis in Primary Immune Deficiency Disease (PIDD).

Case Report: 13-year-old child with combined T and B cell deficiencies was diagnosed of bilateral zone 1 CMV retinitis. Intravitreal injections were unable to be given in a regular and timely manner under general anaesthesia due to her underlying systemic disease. Read More

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http://dx.doi.org/10.1155/2018/8125806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169215PMC
September 2018

Ocular manifestations of cytomegalovirus in immunocompetent hosts.

Curr Opin Ophthalmol 2018 Nov;29(6):535-542

Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, USA.

Purpose Of Review: This review highlights recent studies that have increasingly implicated cytomegalovirus (CMV) as a significant cause of keratouveitis and retinitis in immunocompetent hosts.

Recent Findings: Molecular testing has identified that CMV infection is frequently present in cases of Posner-Schlossman and Fuchs, keratouveitis syndromes previously presumed to be idiopathic conditions. Ocular hypertension and endothelial cell loss are important complications of CMV keratouveitis and are likely mediated by viral invasion of the trabecular meshwork and corneal endothelium. Read More

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http://Insights.ovid.com/crossref?an=00055735-900000000-9924
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http://dx.doi.org/10.1097/ICU.0000000000000521DOI Listing
November 2018
5 Reads

A review on recent drug delivery systems for posterior segment of eye.

Biomed Pharmacother 2018 Nov 5;107:1564-1582. Epub 2018 Sep 5.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Opposite AirForce station, Palaj Basan Road, Village Palaj (Gandhinagar), Gujarat, 382355, India. Electronic address:

Eye is the unique sense organ with complex and sophisticated anatomy and physiology. Being most instrumental for vision, it is secured by varied protective barriers; ranging from static (membranous) to dynamic (vascular) barrier. Although these barriers are very efficient to protect eye from exogenous substances and external stress, it is caught by various irreversible vision impairing ailments like cataract, conjunctivitis, glaucoma, uveitis, diabetic retinopathy (DR), diabetic macular edema (DME), age related macular degeneration (AMD), cytomegalovirus (CMV) retinitis, retinitis pigmentosa (RP), retinal vein occlusion (RVO), endophthalmitis affecting both anterior and posterior segment of eye. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.08.138DOI Listing
November 2018
1 Read

Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS.

J Ophthalmol 2018 2;2018:3830104. Epub 2018 Sep 2.

Molecular Immunology Laboratory and HLA Hemocentro, Ribeirão Preto Medical School University Hospital, Ribeirão Preto, Brazil.

Purpose: Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and alleles have been associated with AIDS disease outcome, we typed locus in patients with AIDS exhibiting or not CR.

Methods: Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). typing was performed using commercial kits. Read More

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http://dx.doi.org/10.1155/2018/3830104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139195PMC
September 2018
1 Read

Uveitis causes according to immune status of patients.

Acta Ophthalmol 2019 Feb 21;97(1):53-59. Epub 2018 Sep 21.

Department of Internal Medicine, Division Immunology, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands.

Purpose: The advances in medicine have led to an increased number of people living with some form of immunodeficiency. Most ocular infections in immunocompromised patients may lead to irreversible blindness. We identify the causes of uveitis in immunocompetent and immunocompromised patients. Read More

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http://dx.doi.org/10.1111/aos.13877DOI Listing
February 2019
3 Reads

Visual acuity outcomes in cytomegalovirus retinitis: early versus late diagnosis.

Br J Ophthalmol 2018 Dec 11;102(12):1607-1610. Epub 2018 Sep 11.

Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA

Aims: To determine if early dilated fundus examination for cytomegalovirus (CMV) retinitis leads to better visual outcomes in areas with limited HIV care, where patients may have long-standing retinitis before they are diagnosed with HIV.

Methods: Twenty-four eyes of 17 patients with CMV retinitis who were seen at an urban HIV clinic in Chiang Mai, Thailand, were included in this retrospective cohort study. Participants were divided into two groups based on the amount of time from the first documented CD4 count below 100 cells/mm to the first eye examination for CMV retinitis. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312191DOI Listing
December 2018
4 Reads

Active cytomegalovirus retinitis after the start of antiretroviral therapy.

Br J Ophthalmol 2019 Feb 8;103(2):157-160. Epub 2018 Sep 8.

Departments of Laboratory Medicine, UCSF and Mount Zion Medical Center, San Francisco, USA.

Patients with AIDS-related cytomegalovirus (CMV) retinitis receiving combined antiretroviral therapy (cART), but not specific anti-CMV therapy, consistently showed active retinitis for several months. Delayed diagnosis and treatment of CMV retinitis may have severe consequences. Patients first entering care with advanced HIV infection and vulnerability to reactivation of latent CMV infection should be screened immediately for CMV retinitis by dilated indirect ophthalmoscopy and treated with specific anti-CMV therapy without delay, in addition to cART. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312406DOI Listing
February 2019
1 Read

Ocular Manifestations of Human Immunodeficiency Virus Infection at a Tertiary Referral Center in Taiwan.

Ocul Immunol Inflamm 2018 Sep 6:1-6. Epub 2018 Sep 6.

a Department of Ophthalmology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.

Purpose: To investigate the prevalence and characteristics of ocular manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in patients treated at a tertiary referral center in Taiwan during a time of highly active antiretroviral therapy (HAART) Materials and Methods: A retrospective cohort study in Taiwan was performed between January 2006 and July 2016. Ocular examination and systemic information were recorded from the HIV-infected patients.

Results: 1242 patients with HIV/AIDS were identified. Read More

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http://dx.doi.org/10.1080/09273948.2018.1499939DOI Listing
September 2018
3 Reads

Aqueous cytomegalovirus DNA and interleukin-8 determination in management of cytomegalovirus retinitis.

Authors:
Heng Miao Jing Hou

Acta Ophthalmol 2018 Sep 5. Epub 2018 Sep 5.

Department of Ophthalmology, People's Hospital, Peking University, Beijing, China.

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http://dx.doi.org/10.1111/aos.13787DOI Listing
September 2018

Opportunistic ocular infections in the setting of HIV.

Curr Opin Ophthalmol 2018 Nov;29(6):558-565

Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Thailand.

Purpose Of Review: The aim of this review is to highlight recent changes in opportunistic ocular infections (OOIs) in the era of modern combination antiretroviral therapy (cART), in the setting of HIV-infected patients.

Recent Findings: Improvements in modern cART has led to a progressive decline in the incidence of OOIs and mortality among patients with AIDS. Not only has there been a decreasing incidence of cytomegalovirus (CMV) retinitis, but there also has been a decline in progression of such retinitis when it does occur in AIDS patients, since the introduction of cART. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000531DOI Listing
November 2018
13 Reads

Diagnostic efficacy of real-time PCR for ocular cytomegalovirus infections.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 27;256(12):2413-2420. Epub 2018 Aug 27.

Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe, Japan.

Purpose: The aim of this study is to determine the efficacy of quantitative real-time PCR (qPCR) and clinical characteristics to diagnose ocular cytomegalovirus (CMV) infections.

Methods: The technical factors were assessed by the outcomes of the qPCR assay at five institutions in Japan using the WHO International Standard of cytomegalovirus. The clinical factors were assessed by examining the aqueous humor samples of 197 eyes of 197 consecutive patients suspected of CMV using the receiver operating characteristics (ROCs). Read More

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http://dx.doi.org/10.1007/s00417-018-4111-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224019PMC
December 2018
1 Read

Occam's razor need not apply: Advanced HIV infection presenting with five simultaneous opportunistic infections and central nervous system lymphoma.

IDCases 2018 8;13:e00437. Epub 2018 Aug 8.

The University of Vermont Medical Center, Larner College of Medicine at the University of Vermont, Burlington, VT, United States.

Patients with Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) are at risk for multiple infectious and oncologic complications. In such cases, Occam's razor need not apply: multiple infections and malignancies are often present concurrently upon presentation to care. A patient off anti-retroviral therapy (ART) for several years developed advanced HIV infection (CD4 count 19 cells/uL) and presented with five simultaneous opportunistic infections including pneumonia (PJP), cytomegalovirus (CMV) retinitis, complex (MAC) bloodstream infection, chronic hepatitis B virus (HBV), and Epstein-Barr virus (EBV) viremia. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097275PMC
August 2018
15 Reads

Macular cytomegalovirus retinitis following dexamethasone intravitreal implant combined with phacoemulsification.

Indian J Ophthalmol 2018 09;66(9):1361-1363

Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A 60-year-old diabetic patient, who had undergone a renal transplant 2 years earlier, presented with sudden decrease in vision in his left eye (LE). He had undergone phacoemulsification combined with intravitreal dexamethasone implant injection in his LE 2 months earlier, for coexistent cataract and diabetic macular edema. Examination revealed necrotizing retinitis with hemorrhages in the macula. Read More

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http://dx.doi.org/10.4103/ijo.IJO_171_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113845PMC
September 2018
13 Reads

Severe cytomegalovirus enterocolitis developing following daratumumab exposure in three patients with multiple myeloma.

Eur J Haematol 2018 Aug 18. Epub 2018 Aug 18.

Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.

Objectives: The risk of cytomegalovirus (CMV) reactivation in multiple myeloma (MM) patients treated with bortezomib-based induction regimens is increased following autologous stem cell transplantation (ASCT). There is paucity of data regarding the risk of CMV infections in MM patients who did not receive bortezomib and ASCT.

Methods: We herein report three cases of heavily pretreated MM patients, receiving daratumumab-containing combination regimens, in whom ASCT had been performed long ago and who recently developed severe CMV-related gastrointestinal disease. Read More

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http://dx.doi.org/10.1111/ejh.13164DOI Listing
August 2018
14 Reads

Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome.

Autops Case Rep 2018 Jul-Sep;8(3):e2018029. Epub 2018 Jul 30.

Universidade de São Paulo, Faculty of Medicine, Department of Anatomic Pathology, Emergency Department and LIM06. São Paulo, SP, Brazil.

Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases. Read More

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http://autopsyandcasereports.org/article/doi/10.4322/acr.201
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http://dx.doi.org/10.4322/acr.2018.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066265PMC
July 2018
15 Reads

Ocular manifestations in patients attending antiretroviral therapy centre at a tertiary care hospital in Himachal Pradesh, India.

Indian J Med Res 2018 05;147(5):496-500

Department of Medicine, Dr. Rajendra Prasad Government Medical College, Kangra, India.

Background & Objectives: Ocular manifestations in HIV/AIDS patients range from adnexal disorders to the posterior segment disease. This study was aimed to evaluate the ocular manifestations, including vision-threatening manifestations in HIV-positive patients attending an antiretroviral therapy centre (ART) of a tertiary care hospital in north India and its association with the CD4+ cell count.

Methods: This cross-sectional study was conducted in the department of Ophthalmology in collaboration with the ART centre. Read More

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http://www.ijmr.org.in/text.asp?2018/147/5/496/238227
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http://dx.doi.org/10.4103/ijmr.IJMR_1037_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094518PMC
May 2018
15 Reads

Visual prognosis, clinical features, and predisposing factors in non-HIV patients with cytomegalovirus retinitis.

Int Ophthalmol 2018 Jul 20. Epub 2018 Jul 20.

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: To study the characteristics and visual outcome of cytomegalovirus retinitis in patients of a tertiary referral ophthalmology center.

Methods: This retrospective cross-sectional study included 16 patients who presented with CMV retinitis between February 2014 and January 2017. Demographics, clinical signs, course of treatment, and visual and anatomical results were analyzed. Read More

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http://dx.doi.org/10.1007/s10792-018-0991-2DOI Listing

Macular oedema due to immune reconstitution uveitis occurring in an HIV-negative patient without cytomegalovirus retinitis.

Eur J Ophthalmol 2018 Jul 1:1120672118787437. Epub 2018 Jul 1.

Ophthalmology Department, Hôpital Nord, Marseille, France.

We describe a case of immune reconstitution uveitis occurring in an HIV-negative patient with bone-marrow transplant, not directly related to cytomegalovirus retinitis. Read More

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http://dx.doi.org/10.1177/1120672118787437DOI Listing
July 2018
1 Read

Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 Are Stimulated within the Eye during Experimental Murine Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression.

J Virol 2018 09 29;92(18). Epub 2018 Aug 29.

Viral Immunology Center, Department of Biology, Georgia State University, Atlanta, Georgia, USA

AIDS-related human cytomegalovirus retinitis remains the leading cause of blindness among untreated HIV/AIDS patients worldwide. To study mechanisms of this disease, we used a clinically relevant animal model of murine cytomegalovirus (MCMV) retinitis with retrovirus-induced murine AIDS (MAIDS) that mimics the progression of AIDS in humans. We found in this model that MCMV infection significantly stimulates ocular suppressor of cytokine signaling 1 (SOCS1) and SOCS3, host proteins which hinder immune-related signaling by cytokines, including antiviral type I and type II interferons. Read More

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http://dx.doi.org/10.1128/JVI.00526-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146705PMC
September 2018
2 Reads

Virus-Induced Anterior Uveitis (VIAU) in Immunocompromised Patients.

Ocul Immunol Inflamm 2018 ;26(5):807-817

a Grupo de Investigación en Neurociencias (NeURos), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario , Bogotá , Colombia.

Purpose: To describe the clinical characteristics, diagnosis, and treatment of VIAU in immunocompromised patients.

Methods: A critical review of literature was performed.

Results: Diagnosis and treatment of VIAU in immunocompromised patients may be a challenge due to atypical clinical-courses, severe presentations, and more frequent recurrences. Read More

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http://dx.doi.org/10.1080/09273948.2018.1483519DOI Listing
September 2018
1 Read

Cytomegalovirus Disease in HIV-infected Children-A Single-Centre Clinical Experience over 23 Years.

J Trop Pediatr 2018 Jun;64(3):215-224

Pediatric Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Background: Cytomegalovirus (CMV) results in significant morbidity and mortality in Human Immunodeficiency Virus (HIV)-infected individuals. There is paucity of literature on paediatric CMV disease, especially from developing countries.

Methods: A retrospective review of records of all HIV-infected children with evidence of CMV disease was done. Read More

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http://dx.doi.org/10.1093/tropej/fmx052DOI Listing
June 2018
3 Reads
0.857 Impact Factor

Development of a Reporter System to Explore MMEJ in the Context of Replacing Large Genomic Fragments.

Mol Ther Nucleic Acids 2018 Jun 22;11:407-415. Epub 2018 Mar 22.

Department of Ophthalmology, Justus-Liebig-University, Giessen 35392, Germany. Electronic address:

Common genome-editing strategies are either based on non-homologous end joining (NHEJ) or, in the presence of a template DNA, based on homologous recombination with long (homology-directed repair [HDR]) or short (microhomology-mediated end joining [MMEJ]) homologous sequences. In the current study, we aim to develop a model system to test the activity of MMEJ after CRISPR/Cas9-mediated cleavage in cell culture. Following successful proof of concept in an episomally based reporter system, we tested template plasmids containing a promoter-less luciferase gene flanked by microhomologous sequences (mhs) of different length (5, 10, 15, 20, 30, and 50 bp) that are complementary to the mouse retinitis pigmentosa GTPase regulator (RPGR)-ORF15, which is under the control of a CMV promoter stably integrated into a HEK293 cell line. Read More

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http://dx.doi.org/10.1016/j.omtn.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992787PMC
June 2018
5 Reads

Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infections.

Mol Vis 2018 18;24:379-394. Epub 2018 May 18.

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA.

Purpose: The purpose of this study was to determine whether the blood-retina barrier is compromised by choroidal murine cytomegalovirus (MCMV) infection, using electron microscopy.

Methods: BALB/c mice were immunosuppressed with methylprednisolone and monoclonal antibodies to CD4 and CD8. At several time points post-MCMV intraperitoneal inoculation, the eyes were removed and analyzed with western blotting and immunoelectron microscopy for the presence of MCMV early antigen (EA) and the host protein RIP3. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957546PMC
November 2018
2 Reads

Human Cytomegalovirus Productively Replicates in Undifferentiated Oral Epithelial Cells.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, USA

Human cytomegalovirus (HCMV) productive replication is most often studied in fibroblasts. , fibroblasts amplify viral titers, but transmission and pathogenesis require the infection of other cell types, most notably epithelial cells. , the study of HCMV infection of epithelial cells has been almost exclusively restricted to ocular epithelial cells. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00903-18
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http://dx.doi.org/10.1128/JVI.00903-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069213PMC
August 2018
11 Reads

Cytomegalovirus retinitis before and after treatment.

J Fr Ophtalmol 2018 May;41(5):477-479

Cabinet Lazrak d'ophtalmologie, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.jfo.2017.09.020DOI Listing

Cytomegalovirus retinitis, in a diabetic immunocompetent patient, after intravitreal ranibizumab injection.

Eur J Ophthalmol 2018 May 1:1120672118772525. Epub 2018 May 1.

1 University Hospital of Ioannina, Ioannina, Greece.

We here report a case of cytomegalovirus retinitis in a diabetic patient that occurred after intravitreal ranibizumab injection. A 75-year-old woman was treated with intravitreal ranibizumab injections for diabetic macular edema. During this period, a retinitis occurred in her left eye along with increased IgG and later IgM cytomegalovirus antibody titers. Read More

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http://dx.doi.org/10.1177/1120672118772525DOI Listing
May 2018
2 Reads

Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome.

Authors:
Jeffrey I Cohen

Front Immunol 2018 23;9:237. Epub 2018 Feb 23.

Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of Akt. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863522PMC
February 2018
10 Reads

Acute Progressive Visual Loss in a Case of Acute Myeloid Leukemia: Challenges in the Utility of Molecular Tests in Early Diagnose of Cytomegalovirus Retinitis.

Case Rep Med 2018 31;2018:2840707. Epub 2018 Jan 31.

Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Cytomegalovirus (CMV) retinitis is one of the rare but debilitating presentations of the CMV infection in children with leukemia. Herein, we report a 12-year-old boy with acute myeloid leukemia complicated by rapid progressive visual loss during relapse of leukemia. The definite diagnosis of CMV retinitis was made after vitreous aspiration. Read More

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http://dx.doi.org/10.1155/2018/2840707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831968PMC
January 2018
1 Read

RAPIDLY PROGRESSIVE NEOVASCULAR GLAUCOMA FROM CYTOMEGALOVIRUS RETINITIS IN A NON-HUMAN IMMUNODEFICIENCY VIRUS PATIENT.

Retin Cases Brief Rep 2018 Mar 12. Epub 2018 Mar 12.

Department of Ophthalmology, Boston Medical Center of Boston University School of Medicine, Boston, Massachusetts.

Purpose: To describe a case of neovascular glaucoma from cytomegalovirus (CMV) retinitis in a human immunodeficiency virus-negative patient with immunosuppression after stem-cell transplant for multiple myeloma.

Methods: Retrospective case report.

Results: A 71-year-old man on monthly infusion of daratumumab for multiple myeloma after stem-cell transplant presenting with a 2-week history of floaters, photophobia, and blurry vision was found to have polymerase chain reaction-confirmed CMV retinitis associated with diffuse occlusive vasculitis. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000734DOI Listing

Good's Syndrome-Association of the Late Onset Combined Immunodeficiency with Thymoma: Review of Literature and Case Report.

Iran J Allergy Asthma Immunol 2018 Feb;17(1):85-93

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Good's syndrome, the adult onset hypogammaglobulinemia associated with thymoma has been explained about six decades ago. It generally presents with recurrent infections and several paraneoplastic syndromes including myasthenia gravis, pure red cell aplasia, connective tissue disorders, superior vena cava, Horner's syndrome, lichen planus and inflammatory bowel disease. Lack of B cell, dysfunction of T cell, CD4+ T cell lymphopenia, reversed CD4/CD8+ T cell ratio, autoantibodies against Th17 related cytokines have been respected as the pathogenesis of the immune dysregulation this syndrome. Read More

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February 2018
12 Reads

Necrotizing retinitis of multifactorial etiology.

Rom J Ophthalmol 2017 Jan-Mar;61(1):49-53

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

We present the case of a 73-year-old woman with osteoporosis, who presented to the emergency room with a sudden vision loss and ocular pain in the right eye, which appeared two days before. The patient mentioned loss of appetite, weight loss for three months and low fever for two weeks. Among the ophthalmological findings, the most important were panuveitis, and large confluent necrotic areas in the peripheral retina. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710053PMC
May 2018
11 Reads

Spectral domain optical coherence tomography and fundus autofluorescence findings in cytomegalovirus retinitis in HIV-infected patients.

Jpn J Ophthalmol 2018 May 14;62(3):373-389. Epub 2018 Feb 14.

AIDS Clinical Center, the National Center for Global Health and Medicine, 1-21-1 Toyama Shinjyuku-ku, Tokyo, 162-8655, Japan.

Purpose: To assess the usefulness of spectral domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) findings in cytomegalovirus (CMV) retinitis.

Study Design: Observational case series.

Methods: Thirteen eyes of 11 human immunodeficiency virus (HIV)-positive patients with CMV retinitis underwent full ophthalmologic examinations, SD-OCT, and 4 eyes of 4 patients underwent FAF. Read More

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http://dx.doi.org/10.1007/s10384-018-0574-9DOI Listing
May 2018
5 Reads

Repeated intraocular crystallization of ganciclovir in one eye after bilateral intravitreal injections: a case report.

BMC Ophthalmol 2018 Feb 9;18(1):36. Epub 2018 Feb 9.

Department of Ophthalmology, The University of Hong Kong, Grantham Hospital, 125 Wong Chuk Hang Road, Aberdeen, Hong Kong, Hong Kong.

Background: Cytomegalovirus (CMV) retinitis is an opportunistic infection that primarily affects immunocompromised individuals. Intravitreal ganciclovir injection monotherapy or in combination with systemic anti-CMV therapy are effective treatments for CMV retinitis. Crystallization of ganciclovir after intravitreal injection is extremely rare. Read More

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http://dx.doi.org/10.1186/s12886-018-0703-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807747PMC
February 2018
2 Reads

Cytomegalovirus Retinitis as a Presenting Feature of Multisystem Disorder: Dyskeratosis Congenita.

Middle East Afr J Ophthalmol 2017 Oct-Dec;24(4):219-221

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Cytomegalovirus (CMV) retinitis is an opportunistic infection commonly seen in disorders that affect the immune system of the body such as acquired immunodeficiency syndrome and hematological malignancies such as leukemia/lymphoma or organ transplantation. The occurrence of CMV retinitis in the absence of such condition should be thoroughly investigated, as it is a strong indicator of poor immune competence. We here report an interesting case of CMV retinitis as a presenting feature of rare multisystem disorde "Dyskeratosis congenita. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_230_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793456PMC
February 2018
11 Reads

Cytomegalovirus associated longitudinally extensive transverse myelitis and acute hepatitis in an immunocompetent adult.

J Clin Neurosci 2018 Apr 1;50:152-154. Epub 2018 Feb 1.

Department of Infectious Diseases, University Hospital Geelong, Victoria, Australia.

Cytomegalovirus can cause severe disease in immunocompromised patients including encephalomyelitis, hepatitis, pneumonitis, colitis and retinitis. CMV induced myelitis and hepatitis are rare in immunocompetent patients. Following a thorough search on the literature using pubmed, there were only 10 well documented CMV-induced transverse myelitis cases reported worldwide. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.01.041DOI Listing
April 2018
7 Reads