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J Ophthalmic Inflamm Infect 2020 Jun 26;10(1):16. Epub 2020 Jun 26.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Cytomegalovirus retinitis is an infectious sight-threatening condition that usually occurs in immunosuppressed individuals, but rare cases of Cytomegalovirus retinitis have been reported in immunocompetent patients.

Findings: A 68-year-old woman without any history of systemic diseases referred to the emergency ward of Farabi eye hospital with a two-week history of decreased vision in her left eye. Fundoscopy of the left eye revealed mild venous tortuosity, hemorrhagic retinitis within the macula, and papillitis. Read More

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Department of Pediatrics and Neonatology, Cloudnine Hospital, Gurgaon, Haryana, India.

Neonatal lupus erythematosus (NLE) should be considered when a newborn develops atrioventricular heart block along with the presence of autoantibodies to Sjogren's syndrome autoantigens in the maternal serum. NLE can also present with features such as cutaneous lesions, hepatic dysfunction or haematological abnormalities. Differential diagnosis usually includes congenital infections as there is a significant overlap of symptoms with NLE. Read More

IDCases 2020 11;21:e00795. Epub 2020 May 11.

Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Cytomegalovirus (CMV) esophagitis is well described in immunocompromised individuals, however, esophageal stricture due to CMV is rare. CMV disease in the setting of the immune reconstitution inflammatory syndrome (IRIS) usually takes the form of an immune-recovery uveitis or retinitis. We describe a young female patient with HIV who developed an esophageal stricture due to CMV within 6 months of starting antiretroviral therapy (ART). Read More

Eur J Ophthalmol 2020 May 27:1120672120926855. Epub 2020 May 27.

Department of Ophthalmology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Introduction: The Epstein-Barr virus is a rare causative pathogen identified in the posterior segment. The majority of cases were presented with a serious condition of acute retinal necrosis, and most of these eyes had poor outcomes. The clinical features and effective treatment options for this condition are still unclear. Read More

Urol Int 2020 May 19:1-6. Epub 2020 May 19.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Introduction: Splenectomy had been previously performed in ABO-incompatible kidney transplantation to reduce the B cell pool. However, studies have shown that patients undergoing splenectomy may have a lifelong susceptibility to infection and mortality. Splenectomy may affect the incidence of cytomegalovirus (CMV) disease even at a very late stage after transplantation in ABO-incompatible recipients. Read More

Ocul Immunol Inflamm 2020 May 12:1-8. Epub 2020 May 12.

Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.

: Overview of the evolving epidemiology of human immunodeficiency virus (HIV)-related ocular disease over time.: Narrative review.: HIV enhances susceptibility to opportunistic eye infections, has direct pathogenic effects, and places patients at risk of immune recovery inflammatory syndromes in previously infected eyes after starting highly-active antiretroviral therapy (HAART). Read More

Rinsho Ketsueki 2020 ;61(4):305-311

Department of Hematology, Nagasaki University Hospital.

Human T-cell leukemia virus type I (HTLV-1) infection and adult T-cell leukemia-lymphoma (ATL) have been shown to cause immunodeficiency. However, only a few cases have been reported on the development of Epstein-Barr virus positive-diffuse large B-cell lymphoma (EBV-DLBCL) in HTLV-1 carriers or in patients with ATL. Here we report a case of a female HTLV-1 carrier who developed cytomegalovirus (CMV) retinitis. Read More

Front Cell Infect Microbiol 2020 7;10:136. Epub 2020 Apr 7.

Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

The purpose of this study was to investigate the clinical features and related laboratory indicators of cytomegalovirus retinitis in HIV infected patients in order to find a suitable laboratory reference guide to aid in the early diagnosis of CMVR, which should improve the prognosis of the severe retinitis. PLHIVs who were admitted to our hospital from January 2010 to December 2016 were included. The diagnosis of AIDS follows the AIDS Treatment Guidelines. Read More

Am J Ophthalmol Case Rep 2020 Jun 6;18:100702. Epub 2020 Apr 6.

Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Purpose: To report a case of an immunocompetent patient who developed cytomegalovirus (CMV) retinitis after complicated cataract surgery resulting in aphakia.

Observations: A 67-year-old man with type 2 diabetes developed retinitis six months after cataract surgery that resulted in aphakia. Anterior chamber DNA testing was positive for CMV. Read More

Zhonghua Yan Ke Za Zhi 2020 Apr;56(4):258-265

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology&Visual Sciences Key Lab, Beijing Tong Ren Hospital, Capital Medical University, Beijing 100730, China.

To investigate the characteristics of retinal nerve fiber layer (RNFL) thickness in AIDS patients with normal fundus, HIV-related microvascular retinopathy (MVR), and cytomegalovirus retinitis (CMVR). In this cross-sectional study, 111 patients were diagnosed with AIDS from 2012 to 2017 by infectious disease physicians in Beijing You'an Hospital. There were 105 males and 6 females, aged 20-65 years. Read More

Ocul Immunol Inflamm 2020 Apr 10:1-6. Epub 2020 Apr 10.

Francis I. Proctor Foundation, University of California, San Francisco, California, USA.

: To determine the incidence of contralateral eye involvement and retinal detachment in HIV-infected patients with cytomegalovirus retinitis treated with repeated intravitreous ganciclovir.: In a prospective cohort study in Northern Thailand, HIV-infected patients with cytomegalovirus retinitis were treated with antiretroviral therapy and intravitreous ganciclovir injections and followed for 3 months for contralateral cytomegalovirus retinitis and retinal detachment.: Of 49 participants with unilateral cytomegalovirus retinitis at enrollment, 7 developed contralateral eye involvement (4. Read More

Ocul Immunol Inflamm 2020 Apr 10:1-3. Epub 2020 Apr 10.

Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

: To describe a case of Cytomegalovirus (CMV) retinitis in both eyes complicated with unilateral corneal endotheliitis in an iatrogenic immunocompromised patient.: A retrospective case report.: A 58-year-old male, on long-term immunosuppressive treatment for chronic glomerulonephritis and nephrotic syndrome. Read More

BMJ Open Ophthalmol 2020 7;5(1):e000331. Epub 2020 Jan 7.

Division of Rheumatology and Immunology, Ohio State University, Columbus, Ohio, USA.

Topic: This paper reviews the ocular side effects of medications used in the treatment of rheumatological conditions.

Clinical Relevance: Rheumatic diseases are inflammatory conditions that may affect the skin, blood vessels, joints, muscles and internal organs. Immunosuppressive agents are often used as treatment and while powerful, they carry side effects and toxicities that need careful monitoring. Read More

Biol Blood Marrow Transplant 2020 Jun 20;26(6):1119-1123. Epub 2020 Feb 20.

Department of Hematology, Sultan Qaboos University Hospital, Muscat, Oman.

Familial hemophagocytic lymphohistiocytosis (FHLH) is a potentially fatal disorder of immune regulation. Management includes chemotherapy followed by hematopoietic stem cell transplantation (HSCT). T cell depleted (TCD)-haploidentical HSCT could be an option for those patients who do not have HLA matching family donor. Read More

Jpn J Ophthalmol 2020 Mar 3;64(2):150-159. Epub 2020 Feb 3.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.

Purpose: Retinal vasculitis and occlusive changes are important signs of posterior uveitis and are possible diagnostic markers for uveitis. However, the frequency of arteritis and phlebitis in various uveitis entities, including infectious uveitis (IU) and non-infectious uveitis (NIU), have not been systematically investigated.

Study Design: Retrospective. Read More

Bone Marrow Transplant 2020 Jun 28;55(6):1147-1160. Epub 2020 Jan 28.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Xi Zhimen South Street No. 11, Beijing, 100044, China.

This study investigated the epidemiological characteristics of cytomegalovirus retinitis (CMVR) after haploidentical hematopoietic stem cell transplantation (HSCT). We studied a cohort of 1466 consecutive patients who had undergone haploidentical HSCT between 2013 and 2017. We documented 34 episodes of CMVR in 31 patients, with a median onset of 167 days after the transplant. Read More

Rheumatology (Oxford) 2020 Jan 28. Epub 2020 Jan 28.

Ocular Inflammatory Clinic, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.

Int J Pharm 2020 Mar 25;577:119084. Epub 2020 Jan 25.

National Metal and Materials Technology Center, National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathum Thani 12120, Thailand.

Ganciclovir (GCV) is an antiviral drug approved for treatment of cytomegalovirus (CMV) retinitis. It can be delivered to the eye via systemic administrations. However, local delivery of GCV that targets the retina is considered as an alternative to increase efficacy of the treatment and lessen side effects. Read More

Scand J Gastroenterol 2020 Jan 9;55(1):55-61. Epub 2020 Jan 9.

Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.

Cytomegalovirus (CMV) is rarely thought to be the cause of significant gastrointestinal infection in immunocompetent children. CMV colitis is seldom observed in young infants. This study aims to examine the clinical features of CMV colitis in Chinese children. Read More

Microorganisms 2019 Dec 28;8(1). Epub 2019 Dec 28.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.

Cytomegalovirus retinitis (CMVR) is a severe, vision-threatening disease that primarily affects immunosuppressed patients. CMVR is the most common ocular opportunistic infection in human immunodeficiency virus (HIV) infected patients and is the leading cause of blindness in this group; however, the incidence of CMVR in HIV patients has dramatically decreased with antiretroviral therapy. Other causes of immunosuppression, including organ transplantation, hematologic malignancies, and iatrogenic immunosuppression, can also lead to the development of CMVR. Read More

Int J Hematol 2020 Mar 13;111(3):434-439. Epub 2019 Dec 13.

Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Chuo-ku, Kumamoto, 860-8556, Japan.

The outcome of relapsed/refractory HIV-associated lymphoma remains poor, even in the era of combined antiretroviral therapy. However, recent reports showed the efficacy of autologous stem cell transplantation (ASCT). We conducted a single-arm, multicenter phase II study in patients with relapsed/refractory HIV-associated lymphoma to assess the safety and efficacy of ASCT. Read More

JAMA Ophthalmol 2019 12 12;137(12):e190039. Epub 2019 Dec 12.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Pediatr Blood Cancer 2020 03 2;67(3):e28101. Epub 2019 Dec 2.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Background: Cytomegalovirus (CMV) disease is underrecognized in children with retinoblastoma. This study investigated rates of CMV infection and disease in this specific population receiving chemotherapy.

Methods: From a cohort of 164 patients with retinoblastoma diagnosed from 2011 to 2018, 107 patients were evaluated for CMV infection determined by antigenemia assay or real-time PCR. Read More

Open Forum Infect Dis 2019 Nov 6;6(11):ofz439. Epub 2019 Nov 6.

Department of Ophthalmology, Szpital Klinczny im. Prof. W. Orłowskiego, Warsaw, Poland.

Background: Cytomegalovirus retinitis is a treatable cause of blindness in people with human immunodeficiency virus (HIV) typically with CD4 counts <50 cells/mm. Diagnosis is with indirect fundoscopy, and treatment is with intravitreal ganciclovir injections or systemic therapy. However, diagnosis and treatment are not widely available in Malawi, which has an adult HIV prevalence estimated at 10. Read More

Infect Disord Drug Targets 2019 Nov 10. Epub 2019 Nov 10.

Texas Tech University Health Sciences Center, El Paso, United States.

Cytomegalovirus (CMV) retinitis in a kidney transplant recipient is a rare illness with only one other reported case in the literature.. We present a case of a 70-year-old kidney transplant recipient female who presented complaining of decreased vision of her right eye. Read More

Pathogens 2019 Nov 4;8(4). Epub 2019 Nov 4.

Institute of Parasitology of Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovakia.

The HIV/acquired immunodeficiency syndrome (AIDS) pandemic has affected the health status of the population in many countries. Early symptomatic HIV infection includes persistent generalized lymphadenopathy (PGL), which can be associated with opportunistic infections, e.g. Read More

J Med Virol 2020 03 18;92(3):394-398. Epub 2019 Nov 18.

Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, Georgia.

The mechanisms that contribute to retinal tissue destruction during the onset and progression of AIDS-related human cytomegalovirus (HCMV) retinitis remain unclear. Evidence for the stimulation of multiple cell death pathways including apoptosis, necroptosis, and pyroptosis during the pathogenesis of experimental murine cytomegalovirus (MCMV) retinitis in mice with retrovirus-induced immunosuppression (MAIDS) has been reported. Parthanatos is a caspase-independent cell death pathway mediated by rapid overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) and distinct from other cell death pathways. Read More

Am J Ophthalmol Case Rep 2019 Dec 10;16:100553. Epub 2019 Sep 10.

Department of Cataract, Narayana Nethralaya, Bangalore, India.

Purpose: To report a case of bilateral acute necrotising retinitis due to cytomegalovirus infection (CMV) in an Asian Indian infant.

Observations: An Asian Indian infant born with a birth weight of 1000 g at 26 week of gestation acquired cytomegalovirus infection from repeated blood transfusion for anemia. During the routine course of ROP screening, both eyes were detected with Type 1 ROP (stage 3 in zone 1 with plus disease) and treated with laser photoablation at 39 + 2 weeks post menstrual age. Read More

Am J Ophthalmol Case Rep 2019 Dec 10;16:100552. Epub 2019 Sep 10.

Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, NY, USA.

Purpose: To report a case of an immunocompetent 64-year-old man who developed cytomegalovirus (CMV) retinitis after using topical difluprednate.

Observations: A 64-year-old man with type 2 diabetes developed hemorrhagic retinitis while using topical difluprednate after penetrating keratoplasty. Polymerase chain reaction of the vitreous was positive for CMV DNA. Read More

BMC Infect Dis 2019 Oct 22;19(1):881. Epub 2019 Oct 22.

Clinic of Infectious Diseases, Department of Health Sciences, ASST Santi Paolo e Carlo, University of Milan, Via di Rudinì 8, 20142, Milan, Italy.

Background: Bendamustine, used for the treatment of indolent B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia, is known to cause prolonged myelosuppression and lymphocytopenia and has been associated with the risk of developing serious and fatal infections. While reports of localized CMV infections in asymptomatic patients exist, disseminated CMV disease has not been described.

Case Presentation: We report the first case of disseminated CMV infection in a 75-year-old male diagnosed with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia with massive bone marrow infiltration. Read More

Ocul Immunol Inflamm 2019 Oct 22:1-6. Epub 2019 Oct 22.

F.I. Proctor Foundation, University of California , San Francisco , California , USA.

: To investigate the use of letermovir 480 mg daily for the treatment of cytomegalovirus (CMV)-associated uveitis (AU). : Retrospective case series of CMV-AU patients on letermovir. : Six eyes of five patients (mean age 54 years) were included. Read More

Hematol Transfus Cell Ther 2020 Jan - Mar;42(1):18-24. Epub 2019 Feb 22.

Facultad de ciencias de la salud, Universidad Icesi, Cali, Colombia; Fundación Valle del Lili, Cali, Colombia. Electronic address:

Objective: Cytomegalovirus infection and disease are significant causes of morbidity and mortality among patients with hematopoietic stem cell transplantation. The aim of this study was to assess the frequency of cytomegalovirus infection and characterize the patients who developed the disease.

Methods: A retrospective cohort study was performed among adult patients, recipients of allogeneic HSTC between 2008 and 2015. Read More

Ocul Immunol Inflamm 2019 Oct 17:1-7. Epub 2019 Oct 17.

Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre , Manchester , UK.

: Cytomegalovirus retinitis (CMVR) is a serious and potentially sight-threatening infection in immunocompromised individuals. Strategies for the management of drug-resistant CMVR are described. : A case of severe bilateral CMVR in a single lung transplant patient, with UL97 mutation conferring ganciclovir-resistance, is presented. Read More

Zhonghua Yan Ke Za Zhi 2019 Oct;55(10):763-768

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, BeijingOphthalmology and Visual Siences Key Laboratory, Beijing Infectious Ophthalmopathy Center, Beijing 100730, China.

To screen the retinopathy in HIV/AIDS patients with both non-mydriatic ultra-wide-field (UWF) retinal imaging and mydriatic fundus examinations with the Superfield lens and a slit lamp biomicroscope, and to evaluate the consistency of two methods and provide reference for future clinical screening work and even technological innovation (such as telemedicine screening and artificial intelligence). Cross sectional study. One hundred and fifty-eight eyes of 80 HIV-positive patients from the Ophthalmology Department of Beijing Youan Hospital were enrolled in this prospective observational study. Read More

Rinsho Ketsueki 2019 ;60(9):1337-1340

Division of Hematology, Department of Medicine, Keio University School of Medicine.

Various types of infectious complications could develop after allogeneic hematopoietic stem cell transplantation (HSCT) due to the associated intensive immunosuppression. Cellular immunity is also impaired, resulting in a higher incidence of viral infections when compared with standard chemotherapy. Cytomegalovirus (CMV) reactivates in seropositive patients under immunosuppression after allogeneic HSCT, causing complications, such as pneumonitis, gastroenteritis, and retinitis. Read More

Ocul Immunol Inflamm 2019 Oct 3:1-6. Epub 2019 Oct 3.

Beijing Yingzhi Aier Eye Hospital , Beijing , China.

: To summarize the prognostic factors of cytomegalovirus (CMV) retinitis (CMVR) in HIV-negative patients treated with multiple intravitreal injections (IVs) of ganciclovir. : A retrospective cohort study (70 eyes) was conducted. Clinical signs, initial and final best corrected visual acuity (BCVA), initial aqueous load of CMV DNA, course of treatment, and occurrence of complications were recorded and analyzed. Read More

Retin Cases Brief Rep 2019 Sep 23. Epub 2019 Sep 23.

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York.

Purpose: To report two cases of cytomegalovirus (CMV) retinitis in renal transplant patients after conversion to belatacept immunosuppression.

Methods: Case report.

Results: Case A was a 41-year-old African American man with no ocular history, chronic hepatitis B infection on entecavir, status-post living relative renal transplant for end-stage renal disease secondary to IgA nephropathy presented with a chief complaint of "blurry vision" in his right eye. Read More

Blood 2019 11;134(20):1755-1763

Department of Hematopoietic Stem Cell Transplantation.

TCRαβ+/CD19+ graft depletion effectively prevents graft-versus-host disease (GVHD). In the current study, we compared the outcomes of hematopoietic stem cell transplantation (HSCT) with TCRαβ+/CD19+ depletion from matched unrelated donors (MUDs) and mismatched related donors (MMRDs) in patients with primary immunodeficiency (PID). A total of 98 pediatric patients with various PIDs underwent HSCT with TCRαβ+/CD19+ graft depletion from MUDs (n = 75) and MMRDs (n = 23). Read More

Int J Ophthalmol 2019 18;12(9):1438-1443. Epub 2019 Sep 18.

Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Aim: To investigate the fundus manifestations and human immunodeficiency virus (HIV) viral loads of acquired immune deficiency syndrome (AIDS) patients before and after highly active antiretroviral therapy (HAART).

Methods: This retrospective study included 21 AIDS patients (42 eyes) who presented to the Department of Ophthalmology, Peking Union Medical College Hospital, from 2007 to 2011. Among the patients, 16 showed a good response to HAART, 3 presented drug resistance and 2 were pre-HAART. Read More

J Infect Chemother 2020 Feb 19;26(2):279-281. Epub 2019 Sep 19.

Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.

We report an AIDS patient with a high HIV RNA copy number in the plasma who was successfully treated for prolonged Mycobacterium avium bacteremia and other complications. An HIV-infected patient with high fever, anemia, high alkaline phosphatase, cystic lung lesions, hepatitis B virus infection and Kaposi's sarcoma was referred to our hospital. PCR of the blood revealed Mycobacterium avium bacteremia and the time to blood culture positivity was 8 days. Read More

Ugeskr Laeger 2019 Sep;181(39)

In this case report an immunocompetent patient developed retinitis after implantation of an intravitreal dexamethasone implant following a primary infection with cytomegalovirus. The implant was prescribed due to a history following a central vein occlusion with macular oedema and loss of vision. Vision improved after implantation, however, due to retinitis a vitrectomy was performed proving infection with cytomegalovirus. Read More

Nepal J Ophthalmol 2019 Jan;11(21):11-18

Department of Ophthalmology, SHKM, GMC Nalhar, Nuh.

Introduction: HIV/AIDS is a disorder which affects multiple systems in our body but ophthalmic manifestations do occur in 70-80% of patients sometime during their lifetime. Eye is affected either directly by HIV virus or indirectly through various opportunistic infections. HIV related ophthalmic manifestations are wide and can affect any part of eye from a dnexal disorders to posterior segment diseases including the optic nerve and the optic tract. Read More

Am J Ophthalmol Case Rep 2019 Dec 15;16:100545. Epub 2019 Aug 15.

Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, 75390-9057, USA.

Purpose: To report an atypical case of vitreoretinal lymphoma, secondary to non-central nervous system (non-CNS) systemic lymphoma, masquerading as an infectious retinitis.

Observations: A 76-year-old female with a history of cecal diffuse large B-cell lymphoma with two prior occurrences of posterior segment ocular involvement presented with a complaint of blurry vision in the right eye. Exam findings were significant for large areas of retinal whitening and retinal hemorrhages in the absence of choroidal lesions or significant vitritis. Read More

Int J Ophthalmol 2019 18;12(8):1351-1355. Epub 2019 Aug 18.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tong Ren Hospital, Capital Medical University, Beijing 100730, China.

The effect of intravitreal ganciclovir injection combined with intravenous infusion on acquired immune deficiency syndrome (AIDS) patients with cytomegalovirus retinitis (CMVR) was investigated. A total of 32 eyes in 23 AIDS patients diagnosed as CMVR from 2017 to 2018 were included in the retrospective study. All patients underwent induction therapy by using intravenous drip of the anti-cytomegalovirus (CMV) agent ganciclovir (5 mg/kg ) combined with intravitreal ganciclovir injection (3 mg/time, 2 times/wk). Read More

Exp Ther Med 2019 Sep 26;18(3):2271-2277. Epub 2019 Jul 26.

Department of Gastroenterology, Gifu University Hospital, Gifu 501-1194, Japan.

Cytomegalovirus (CMV) is a ubiquitous member of the Herpesviridae family that can present with a variety of clinical manifestations, including encephalitis, retinitis, interstitial pneumonia and colitis. These serious symptoms are generally observed as opportunistic infections in immunocompromised hosts, including patients with acquired immunodeficiency syndrome and those receiving steroids and/or immunosuppressants. Symptomatic CMV infections in patients with ulcerative colitis are found in patients treated with steroids and/or immunosuppressants but rarely affect those who are not taking these agents. Read More

Am J Ophthalmol 2019 12 23;208:376-386. Epub 2019 Aug 23.

University of Lyon, Lyon, France; Laboratory of Virology, Institut des Agents Infectieux (IAI) de Lyon, Hospices Civils de Lyon, Lyon, France; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, Centre National de la Recherche Scientifique (CNRS) UMR5308, Ecole Nationale Supérieure de Lyon (ENS), Equipe Virpath, Lyon, France.

Purpose: To evaluate outcomes of patients treated with intensive intravitreal therapy and to describe the evolution of quantitative real-time polymerase chain reaction (qPCR) in patients treated for acute retinal necrosis (ARN) syndrome.

Design: Retrospective observational case series.

Methods: This study included 25 eyes of 24 patients with ARN who were treated and followed up in 2 departments of ophthalmology in Lyon, France. Read More

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Aug 21. Epub 2019 Aug 21.

Department of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.

Aims: Cases of infectious uveitis in immunodeficient patients may present with atypical clinical features because the clinical course of disease is usually affected by the compromised immune system. Therefore, it is sometimes difficult to determine the correct diagnosis. The aim of this study was to evaluate a prevalence of immunodeficient HIV-negative individuals among patients with infectious uveitis and to assess diagnostic and therapeutic approaches. Read More

Front Genet 2019 23;10:616. Epub 2019 Jul 23.

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States.

Human cytomegalovirus (HCMV) is a ubiquitous herpes virus (human herpes virus 5) with the highest morbidity and mortality rates compared to other herpes viruses. Risk groups include very young, elderly, transplant recipient, and immunocompromised individuals. HCMV may cause retinitis, encephalitis, hepatitis, esophagitis, colitis, pneumonia, neonatal infection sequelae, inflammatory, and age-related diseases. Read More