2,893 results match your criteria Retinitis CMV


[The ocular manifestations of human immunodeficiency virus and syphilis coinfection].

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):267-272

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ocular manifestations of human immunodeficiency virus (HIV) and syphilis coinfection. A retrospective analysis of the ocular manifestations was carried out in 27 patients (54 eyes) diagnosed as syphilis and HIV coinfection by the Department of Infectious Medicine in Peking Union Medical College Hospital during the years of 2006-2017. The research included 26 males and 1 female, aging from 24 to 76 years old, with a mean age of 40. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.04.008DOI Listing
April 2019
2 Reads

Cytomegalovirus Retinitis in Children and Adolescents with Acute Leukemia following allogeneic Hematopoietic Stem Cell Transplantation.

Transpl Infect Dis 2019 Apr 10:e13089. Epub 2019 Apr 10.

Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster.

Cytomegalovirus retinitis (CMVR) may occur after allogeneic hematopoietic stem cell transplantation (HSCT). However, little is known about its incidence, strategies for ophthalmic surveillance, and timely implementation of adequate antiviral treatment in pediatric allogeneic HSCT recipients. We provide a retrospective analysis of the epidemiology and clinical features of CMVR in pediatric allogeneic HSCT patients transplanted at our center over a 16-year period. Read More

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http://dx.doi.org/10.1111/tid.13089DOI Listing
April 2019
5 Reads

Polymerase chain reaction analysis of aqueous humor specimens in the diagnosis of cytomegalovirus retinitis in AIDS patients.

Eur J Ophthalmol 2019 Apr 10:1120672119841777. Epub 2019 Apr 10.

Beijing DiTan Hospital, Capital Medical University, Beijing, China.

Purpose: To determine the value of the polymerase chain reaction analysis of aqueous humor specimens as a tool to diagnose cytomegalovirus retinitis in AIDS patients.

Methods: In all, 63 AIDS patients were evaluated in this study. They were sorted into two diagnostic categories: eyes with active cytomegalovirus retinitis and eyes without active cytomegalovirus retinitis. Read More

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http://dx.doi.org/10.1177/1120672119841777DOI Listing

Cytomegalovirus Retinitis Associated with Lenalidomide Use for Multiple Myeloma in an Immunocompetent Patient.

Case Rep Ophthalmol Med 2019 25;2019:3516394. Epub 2019 Feb 25.

Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, NC-205, Houston, TX 77030, USA.

Purpose: The aim of this report is to present a case of cytomegalovirus (CMV) retinitis in an immunocompetent patient using lenalidomide.

Methods: Case report with fundus photography, spectral-domain optical coherence tomography, and fluorescein angiography imaging.

Results: A 55-year-old male with history of multiple myeloma treated with lenalidomide presented with blurriness and floaters in his right eye and was found to have vitreous biopsy-confirmed CMV retinitis. Read More

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https://www.hindawi.com/journals/criopm/2019/3516394/
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http://dx.doi.org/10.1155/2019/3516394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413394PMC
February 2019
4 Reads

Cytomegalovirus retinitis in the post-cART era.

Curr Ophthalmol Rep 2018 Jun 2;6(2):133-144. Epub 2018 May 2.

Department of Ophthalmology, Weill Cornell Medicine.

Purpose Of Review: To review the epidemiology, diagnosis, and management of cytomegalovirus retinitis (CMVR) in the post-combined antiretroviral era (cART) era.

Recent Findings: Although cART has dramatically reduced CMVR incidence and morbidity in the HIV population, CMVR continues to cause significant vision loss in both HIV and non-HIV patients, especially amongst patients without immune reconstitution. Advances in imaging including ultra-widefield fundus and autofluorescence imaging, optical coherence tomography, and adaptive optics may reflect CMVR activity; however, the diagnosis remains a clinical one. Read More

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http://dx.doi.org/10.1007/s40135-018-0173-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419753PMC
June 2018
1 Read

Viral retinitis: diagnosis and management in the era of biologic immunosuppression - a review.

Clin Exp Ophthalmol 2019 Mar 12. Epub 2019 Mar 12.

Moorfields Eye Hospital, London, UK.

Necrotising retinitis is a rare ocular infection that historically led to high rates of visual morbidity. While acute retinal retinal necrosis occurs in immunocompetent patients, the majority of cases are associated with immunocompromise such as in cytomegalovirus retinitis and progressive outer retinal necrosis. This review summarises the clinical and diagnostic features, management, and outcomes of herpetic retinitis. Read More

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http://doi.wiley.com/10.1111/ceo.13500
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http://dx.doi.org/10.1111/ceo.13500DOI Listing
March 2019
9 Reads

Concurrent cerebral toxoplasmosis and cytomegalovirus retinitis in a patient with human immunodeficiency virus.

Can J Ophthalmol 2019 Feb 19;54(1):e33-e35. Epub 2018 Jun 19.

Department of Neurology, Indiana University School of Medicine, Indianapolis, Ind; Department of Ophthalmology, Indiana University School of Medicine; Department of Neurosurgery, Indiana University School of Medicine. Electronic address:

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http://dx.doi.org/10.1016/j.jcjo.2018.04.025DOI Listing
February 2019
3 Reads

A cross-sectional study of cytomegalovirus retinitis in HIV-1 infected adults in Nigeria.

Niger J Clin Pract 2019 Mar;22(3):293-297

Department of Medicine, Infectious and Tropical Disease Unit, College of Health Sciences, Bayero University/Aminu Kano Teaching Hospital, UngwaUku, Kano, Nigeria.

Background: Cytomegalovirus (CMV) retinitis is one of the most important opportunistic infections in HIV-infected patients in developing countries before the introduction of highly active antiretroviral therapy. In Nigerian and African HIV populations, CMV retinitis is under-reported.

Patients And Methods: In a cross-sectional study, 250 HIV-infected adults ≥18 years were recruited by systematic random sampling from March to August 2013. Read More

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http://dx.doi.org/10.4103/njcp.njcp_82_18DOI Listing
March 2019
2 Reads

[Clinical characteristics and T-lymphocyte subsets in 48 acquired immune deficiency syndrome patients with cytomegalovirus infections].

Zhonghua Nei Ke Za Zhi 2019 Mar;58(3):191-197

Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China (is working on the Department of Infectious Diseases, the Third Hospital of Qinhuangdao, Qinhuangdao 066000, China).

To investigate the clinical features and T lymphocytes subsets in patients with acquired immune deficiency syndrome (AIDS) and cytomegalovirus (CMV) infection. A total of 48 hospitalized patients with human immunodeficiency virus (HIV)-1/AIDS and CMV infections were recruited at Peking Union Medical College Hospital from Jan 2010 to Aug 2017. Their clinical features and immune function were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.03.008DOI Listing
March 2019
7 Reads

hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye.

Int J Mol Sci 2019 Feb 16;20(4). Epub 2019 Feb 16.

Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.

Human retinal pigment epithelial (hRPE) cells are important for the establishment and maintenance of the immune privilege of the eye. They function as target cells for human cytomegalovirus (hCMV), but are able to restrict viral replication. hCMV causes opportunistic posterior uveitis such as retinitis and chorioretinitis. Read More

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http://dx.doi.org/10.3390/ijms20040858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413209PMC
February 2019
4 Reads

Monitoring of cytomegalovirus infection in non-transplant pediatric acute lymphoblastic leukemia patients during chemotherapy.

Medicine (Baltimore) 2019 Jan;98(4):e14256

Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, Thailand.

Cytomegalovirus (CMV) infection is a significant cause of morbidity and mortality in the posttransplant setting; however, it is increasingly recognized in pediatric leukemia during chemotherapy. This study assessed the prevalence and associated factors of CMV infection in pediatric non-transplant leukemia patients.This was a cross-sectional study of 50 pediatric acute lymphoblastic leukemia (ALL) patients receiving chemotherapy at Ramathibodi Hospital from December 2015 to December 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000014256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358396PMC
January 2019
11 Reads

CD4+ cells as a potential biomarker for cytomegalovirus retinitis in children with acute lymphocytic leukemia.

Chin Med J (Engl) 2019 02;132(3):356-359

Department of Hematology, Hebei Children's Hospital, Hebei Medical University, Shijiazhuang, Hebei 050031, China.

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http://dx.doi.org/10.1097/CM9.0000000000000065DOI Listing
February 2019
2 Reads

Adult T-Cell Leukemia/Lymphoma-Related Ocular Manifestations: Analysis of the First Large-Scale Nationwide Survey.

Front Microbiol 2018 8;9:3240. Epub 2019 Jan 8.

Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Adult T-cell leukemia/lymphoma (ATL) is a rare and aggressive T-cell malignancy with a high mortality rate, resulting in a lack of information among ophthalmologists. Here, we investigated the state of ophthalmic medical care for ATL and ATL-related ocular manifestations by conducting the first large-scale nationwide survey in Japan. A total of 115 facilities were surveyed, including all university hospitals in Japan that were members of the Japanese Ophthalmological Society and regional core facilities that were members of the Japanese Ocular Inflammation Society. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331419PMC
January 2019
1 Read

Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis.

Antimicrob Agents Chemother 2019 Mar 26;63(3). Epub 2019 Feb 26.

Duke University School of Medicine, Division of Infectious Diseases, Durham, North Carolina, USA

Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but its efficacy in other settings is unknown. We recently used letermovir for salvage treatment in four solid organ transplant recipients with ganciclovir-resistant CMV retinitis. Read More

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http://dx.doi.org/10.1128/AAC.02337-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395918PMC
March 2019
1 Read

: ophthalmic complications following lung transplantation.

J Thorac Dis 2018 Nov;10(11):6285-6297

Respiratory Institute, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Ophthalmic complications in the lung transplant population are a little-known entity. It includes a spectrum of diseases ranging from infections such as cytomegalovirus (CMV) retinitis, herpetic keratitis, to non-infectious complications such as posterior subcapsular cataracts (PSCs), cyclosporine retinopathy, and post-transplant lymphoproliferative disorder (PTLD). These diseases can be attributed to high levels of immunosuppression, advanced age, and drug-specific side effects. Read More

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http://jtd.amegroups.com/article/view/24861/19111
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http://dx.doi.org/10.21037/jtd.2018.09.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297435PMC
November 2018
10 Reads

RETINAL FINDINGS IN PRESUMED INFECTIOUS POSTERIOR UVEITIS AND CORRELATION WITH POLYMERASE CHAIN REACTION RESULTS.

Retina 2018 Dec 27. Epub 2018 Dec 27.

Department of Ophthalmology, the Icahn School of Medicine at Mount Sinai, New York, New York.

Purpose: To correlate demographics, retinal lesion characteristics, and host immune status with the pathogen found on polymerase chain reaction analysis of aqueous fluid in patients with suspected infectious posterior uveitis.

Methods: Medical records of patients who underwent anterior chamber paracentesis for suspected infectious posterior uveitis and had retinal photographs between 2014 and 2016 at a single institution were reviewed. Data collection included demographics, clinical appearance of the lesions, and polymerase chain reaction results. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002423DOI Listing
December 2018
3 Reads

Successively bilateral cytomegalovirus retinitis in immunocompromised patient with Good's syndrome.

Int J Ophthalmol 2018 18;11(12):2021-2023. Epub 2018 Dec 18.

Beijing Institute of Ophthalmology, Beijing 100005, China.

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http://dx.doi.org/10.18240/ijo.2018.12.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288527PMC
December 2018
1 Read

Initial intravitreal injection of high-dose ganciclovir for cytomegalovirus retinitis in HIV-negative patients.

BMC Ophthalmol 2018 Dec 10;18(1):314. Epub 2018 Dec 10.

Shanghai Aier Eye Hospital, Shanghai, China, No. 1286, Hongqiao Road, Changning District, Shanghai, 200050, China.

Background: The purpose of this study is to examine the clinical outcomes achieved by using initial high-dose intravitreal ganciclovir injections to treat cytomegalovirus retinitis in patients without human immunodeficiency virus (HIV) infection.

Methods: Twenty-four eyes (24 patients) with cytomegalovirus retinitis received multiple intravitreal injections of ganciclovir in weekly intervals. A higher dose (6 mg) of ganciclovir was applied at the first intravitreal injection, and a lower dose was used for maintenance. Read More

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http://dx.doi.org/10.1186/s12886-018-0983-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288921PMC
December 2018
5 Reads

Burden of cytomegalovirus reactivation post kidney transplant with antithymocyte globulin use in Thailand: A retrospective cohort study.

F1000Res 2018 28;7:1568. Epub 2018 Sep 28.

Division of Infectious disease, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.

Cytomegalovirus (CMV) is an important cause of infectious complications after kidney transplantation (KT), especially among patients receiving antithymocyte globulin (ATG). CMV infection can result in organ dysfunction and indirect effects such as graft rejection, graft failure, and opportunistic infections Prevention of CMV reactivation includes pre-emptive or prophylactic approaches. Access to valganciclovir prophylaxis is limited by high cost. Read More

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https://f1000research.com/articles/7-1568/v1
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http://dx.doi.org/10.12688/f1000research.16321.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234719PMC
September 2018
15 Reads

Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt's lymphoma and Kaposi's sarcoma.

BMC Cancer 2018 Nov 8;18(1):1080. Epub 2018 Nov 8.

Department of Infectious Diseases, Chonnam National University Medical School, 42, Jebong Ro, Donggu, Gwangju, 61469, Korea.

Background: The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who are severely immunosuppressed or have incomplete virologic suppression.

Case Presentation: We report a case of dual primary ADCs, especially NHL followed by KS, in a 70-year-old HIV-infected man who was on antiretroviral therapy and had successful virologic suppression. Read More

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http://dx.doi.org/10.1186/s12885-018-5019-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225729PMC
November 2018
15 Reads

Spectrum of Newly Diagnosed Cytomegalovirus Retinitis in a Developing Country in the HAART Era.

Ocul Immunol Inflamm 2018 Nov 5:1-7. Epub 2018 Nov 5.

a Advanced Eye Centre, Department of Ophthalmology , Post Graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: To characterize the presenting features of cytomegalovirus (CMV) retinitis in HIV-positive patients in a developing country in the HAART era.

Methods: Retrospective chart review of all patients with CMV retinitis seen at a tertiary-care referral center between January 2006 to June 2017. Demographic and clinical data were collected to study the presenting features and risk factors for blindness. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
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http://dx.doi.org/10.1080/09273948.2018.1538460DOI Listing
November 2018
17 Reads
1.440 Impact Factor

Comparison of intravitreal ganciclovir monotherapy and combination with foscarnet as initial therapy for cytomegalovirus retinitis.

Int J Ophthalmol 2018 18;11(10):1638-1642. Epub 2018 Oct 18.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 11217, Taiwan, China.

Aim: To compare the effectiveness between multiple intravitreal injections of ganciclovir alone and combined with foscarnet as initial treatment for patients with newly-onset cytomegalovirus retinitis (CMVR).

Methods: The retrospective study observed 37 patients (58 eyes) who suffered from CMVR onset between 2013 and 2015. Among them, 35 eyes underwent 4 weekly intravitreal injections of 3. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.10.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192958PMC
October 2018
13 Reads
0.500 Impact Factor

Cytomegalovirus Retinitis in Primary Immune Deficiency Disease.

Case Rep Ophthalmol Med 2018 19;2018:8125806. Epub 2018 Sep 19.

Department of Ophthalmology, Hospital Shah Alam, Selangor, Malaysia.

Introduction: To report an unusual case of CMV retinitis in Primary Immune Deficiency Disease (PIDD).

Case Report: 13-year-old child with combined T and B cell deficiencies was diagnosed of bilateral zone 1 CMV retinitis. Intravitreal injections were unable to be given in a regular and timely manner under general anaesthesia due to her underlying systemic disease. Read More

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http://dx.doi.org/10.1155/2018/8125806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169215PMC
September 2018

Ocular manifestations of cytomegalovirus in immunocompetent hosts.

Curr Opin Ophthalmol 2018 Nov;29(6):535-542

Francis I. Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, USA.

Purpose Of Review: This review highlights recent studies that have increasingly implicated cytomegalovirus (CMV) as a significant cause of keratouveitis and retinitis in immunocompetent hosts.

Recent Findings: Molecular testing has identified that CMV infection is frequently present in cases of Posner-Schlossman and Fuchs, keratouveitis syndromes previously presumed to be idiopathic conditions. Ocular hypertension and endothelial cell loss are important complications of CMV keratouveitis and are likely mediated by viral invasion of the trabecular meshwork and corneal endothelium. Read More

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http://Insights.ovid.com/crossref?an=00055735-900000000-9924
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http://dx.doi.org/10.1097/ICU.0000000000000521DOI Listing
November 2018
6 Reads

A review on recent drug delivery systems for posterior segment of eye.

Biomed Pharmacother 2018 Nov 5;107:1564-1582. Epub 2018 Sep 5.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Opposite AirForce station, Palaj Basan Road, Village Palaj (Gandhinagar), Gujarat, 382355, India. Electronic address:

Eye is the unique sense organ with complex and sophisticated anatomy and physiology. Being most instrumental for vision, it is secured by varied protective barriers; ranging from static (membranous) to dynamic (vascular) barrier. Although these barriers are very efficient to protect eye from exogenous substances and external stress, it is caught by various irreversible vision impairing ailments like cataract, conjunctivitis, glaucoma, uveitis, diabetic retinopathy (DR), diabetic macular edema (DME), age related macular degeneration (AMD), cytomegalovirus (CMV) retinitis, retinitis pigmentosa (RP), retinal vein occlusion (RVO), endophthalmitis affecting both anterior and posterior segment of eye. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.08.138DOI Listing
November 2018
3 Reads

Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS.

J Ophthalmol 2018 2;2018:3830104. Epub 2018 Sep 2.

Molecular Immunology Laboratory and HLA Hemocentro, Ribeirão Preto Medical School University Hospital, Ribeirão Preto, Brazil.

Purpose: Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and alleles have been associated with AIDS disease outcome, we typed locus in patients with AIDS exhibiting or not CR.

Methods: Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). typing was performed using commercial kits. Read More

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http://dx.doi.org/10.1155/2018/3830104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139195PMC
September 2018
2 Reads

Uveitis causes according to immune status of patients.

Acta Ophthalmol 2019 Feb 21;97(1):53-59. Epub 2018 Sep 21.

Department of Internal Medicine, Division Immunology, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands.

Purpose: The advances in medicine have led to an increased number of people living with some form of immunodeficiency. Most ocular infections in immunocompromised patients may lead to irreversible blindness. We identify the causes of uveitis in immunocompetent and immunocompromised patients. Read More

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http://dx.doi.org/10.1111/aos.13877DOI Listing
February 2019
6 Reads

Visual acuity outcomes in cytomegalovirus retinitis: early versus late diagnosis.

Br J Ophthalmol 2018 Dec 11;102(12):1607-1610. Epub 2018 Sep 11.

Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA

Aims: To determine if early dilated fundus examination for cytomegalovirus (CMV) retinitis leads to better visual outcomes in areas with limited HIV care, where patients may have long-standing retinitis before they are diagnosed with HIV.

Methods: Twenty-four eyes of 17 patients with CMV retinitis who were seen at an urban HIV clinic in Chiang Mai, Thailand, were included in this retrospective cohort study. Participants were divided into two groups based on the amount of time from the first documented CD4 count below 100 cells/mm to the first eye examination for CMV retinitis. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312191DOI Listing
December 2018
5 Reads

Active cytomegalovirus retinitis after the start of antiretroviral therapy.

Br J Ophthalmol 2019 Feb 8;103(2):157-160. Epub 2018 Sep 8.

Departments of Laboratory Medicine, UCSF and Mount Zion Medical Center, San Francisco, USA.

Patients with AIDS-related cytomegalovirus (CMV) retinitis receiving combined antiretroviral therapy (cART), but not specific anti-CMV therapy, consistently showed active retinitis for several months. Delayed diagnosis and treatment of CMV retinitis may have severe consequences. Patients first entering care with advanced HIV infection and vulnerability to reactivation of latent CMV infection should be screened immediately for CMV retinitis by dilated indirect ophthalmoscopy and treated with specific anti-CMV therapy without delay, in addition to cART. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312406DOI Listing
February 2019
3 Reads

Ocular Manifestations of Human Immunodeficiency Virus Infection at a Tertiary Referral Center in Taiwan.

Ocul Immunol Inflamm 2018 Sep 6:1-6. Epub 2018 Sep 6.

a Department of Ophthalmology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.

Purpose: To investigate the prevalence and characteristics of ocular manifestations of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in patients treated at a tertiary referral center in Taiwan during a time of highly active antiretroviral therapy (HAART) Materials and Methods: A retrospective cohort study in Taiwan was performed between January 2006 and July 2016. Ocular examination and systemic information were recorded from the HIV-infected patients.

Results: 1242 patients with HIV/AIDS were identified. Read More

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http://dx.doi.org/10.1080/09273948.2018.1499939DOI Listing
September 2018
6 Reads

Aqueous cytomegalovirus DNA and interleukin-8 determination in management of cytomegalovirus retinitis.

Authors:
Heng Miao Jing Hou

Acta Ophthalmol 2019 May 5;97(3):e483-e484. Epub 2018 Sep 5.

Department of Ophthalmology, People's Hospital, Peking University, Beijing, China.

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http://doi.wiley.com/10.1111/aos.13787
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http://dx.doi.org/10.1111/aos.13787DOI Listing
May 2019
4 Reads

Opportunistic ocular infections in the setting of HIV.

Curr Opin Ophthalmol 2018 Nov;29(6):558-565

Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Thailand.

Purpose Of Review: The aim of this review is to highlight recent changes in opportunistic ocular infections (OOIs) in the era of modern combination antiretroviral therapy (cART), in the setting of HIV-infected patients.

Recent Findings: Improvements in modern cART has led to a progressive decline in the incidence of OOIs and mortality among patients with AIDS. Not only has there been a decreasing incidence of cytomegalovirus (CMV) retinitis, but there also has been a decline in progression of such retinitis when it does occur in AIDS patients, since the introduction of cART. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000531DOI Listing
November 2018
21 Reads

Diagnostic efficacy of real-time PCR for ocular cytomegalovirus infections.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 27;256(12):2413-2420. Epub 2018 Aug 27.

Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe, Japan.

Purpose: The aim of this study is to determine the efficacy of quantitative real-time PCR (qPCR) and clinical characteristics to diagnose ocular cytomegalovirus (CMV) infections.

Methods: The technical factors were assessed by the outcomes of the qPCR assay at five institutions in Japan using the WHO International Standard of cytomegalovirus. The clinical factors were assessed by examining the aqueous humor samples of 197 eyes of 197 consecutive patients suspected of CMV using the receiver operating characteristics (ROCs). Read More

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http://dx.doi.org/10.1007/s00417-018-4111-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224019PMC
December 2018
4 Reads

Occam's razor need not apply: Advanced HIV infection presenting with five simultaneous opportunistic infections and central nervous system lymphoma.

IDCases 2018 8;13:e00437. Epub 2018 Aug 8.

The University of Vermont Medical Center, Larner College of Medicine at the University of Vermont, Burlington, VT, United States.

Patients with Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) are at risk for multiple infectious and oncologic complications. In such cases, Occam's razor need not apply: multiple infections and malignancies are often present concurrently upon presentation to care. A patient off anti-retroviral therapy (ART) for several years developed advanced HIV infection (CD4 count 19 cells/uL) and presented with five simultaneous opportunistic infections including pneumonia (PJP), cytomegalovirus (CMV) retinitis, complex (MAC) bloodstream infection, chronic hepatitis B virus (HBV), and Epstein-Barr virus (EBV) viremia. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097275PMC
August 2018
22 Reads

Macular cytomegalovirus retinitis following dexamethasone intravitreal implant combined with phacoemulsification.

Indian J Ophthalmol 2018 09;66(9):1361-1363

Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A 60-year-old diabetic patient, who had undergone a renal transplant 2 years earlier, presented with sudden decrease in vision in his left eye (LE). He had undergone phacoemulsification combined with intravitreal dexamethasone implant injection in his LE 2 months earlier, for coexistent cataract and diabetic macular edema. Examination revealed necrotizing retinitis with hemorrhages in the macula. Read More

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http://dx.doi.org/10.4103/ijo.IJO_171_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113845PMC
September 2018
13 Reads

Severe cytomegalovirus enterocolitis developing following daratumumab exposure in three patients with multiple myeloma.

Eur J Haematol 2018 Aug 18. Epub 2018 Aug 18.

Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.

Objectives: The risk of cytomegalovirus (CMV) reactivation in multiple myeloma (MM) patients treated with bortezomib-based induction regimens is increased following autologous stem cell transplantation (ASCT). There is paucity of data regarding the risk of CMV infections in MM patients who did not receive bortezomib and ASCT.

Methods: We herein report three cases of heavily pretreated MM patients, receiving daratumumab-containing combination regimens, in whom ASCT had been performed long ago and who recently developed severe CMV-related gastrointestinal disease. Read More

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http://dx.doi.org/10.1111/ejh.13164DOI Listing
August 2018
15 Reads

Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome.

Autops Case Rep 2018 Jul-Sep;8(3):e2018029. Epub 2018 Jul 30.

Universidade de São Paulo, Faculty of Medicine, Department of Anatomic Pathology, Emergency Department and LIM06. São Paulo, SP, Brazil.

Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases. Read More

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http://autopsyandcasereports.org/article/doi/10.4322/acr.201
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http://dx.doi.org/10.4322/acr.2018.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066265PMC
July 2018
16 Reads

Ocular manifestations in patients attending antiretroviral therapy centre at a tertiary care hospital in Himachal Pradesh, India.

Indian J Med Res 2018 05;147(5):496-500

Department of Medicine, Dr. Rajendra Prasad Government Medical College, Kangra, India.

Background & Objectives: Ocular manifestations in HIV/AIDS patients range from adnexal disorders to the posterior segment disease. This study was aimed to evaluate the ocular manifestations, including vision-threatening manifestations in HIV-positive patients attending an antiretroviral therapy centre (ART) of a tertiary care hospital in north India and its association with the CD4+ cell count.

Methods: This cross-sectional study was conducted in the department of Ophthalmology in collaboration with the ART centre. Read More

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http://www.ijmr.org.in/text.asp?2018/147/5/496/238227
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http://dx.doi.org/10.4103/ijmr.IJMR_1037_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094518PMC
May 2018
16 Reads

Visual prognosis, clinical features, and predisposing factors in non-HIV patients with cytomegalovirus retinitis.

Int Ophthalmol 2018 Jul 20. Epub 2018 Jul 20.

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: To study the characteristics and visual outcome of cytomegalovirus retinitis in patients of a tertiary referral ophthalmology center.

Methods: This retrospective cross-sectional study included 16 patients who presented with CMV retinitis between February 2014 and January 2017. Demographics, clinical signs, course of treatment, and visual and anatomical results were analyzed. Read More

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http://dx.doi.org/10.1007/s10792-018-0991-2DOI Listing
July 2018
1 Read

Macular oedema due to immune reconstitution uveitis occurring in an HIV-negative patient without cytomegalovirus retinitis.

Eur J Ophthalmol 2019 Jan 16;29(1):NP17-NP20. Epub 2018 Jul 16.

Ophthalmology Department, Hôpital Nord, Marseille, France.

We describe a case of immune reconstitution uveitis occurring in an HIV-negative patient with bone-marrow transplant, not directly related to cytomegalovirus retinitis. Read More

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http://dx.doi.org/10.1177/1120672118787437DOI Listing
January 2019
2 Reads

Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 Are Stimulated within the Eye during Experimental Murine Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression.

J Virol 2018 09 29;92(18). Epub 2018 Aug 29.

Viral Immunology Center, Department of Biology, Georgia State University, Atlanta, Georgia, USA

AIDS-related human cytomegalovirus retinitis remains the leading cause of blindness among untreated HIV/AIDS patients worldwide. To study mechanisms of this disease, we used a clinically relevant animal model of murine cytomegalovirus (MCMV) retinitis with retrovirus-induced murine AIDS (MAIDS) that mimics the progression of AIDS in humans. We found in this model that MCMV infection significantly stimulates ocular suppressor of cytokine signaling 1 (SOCS1) and SOCS3, host proteins which hinder immune-related signaling by cytokines, including antiviral type I and type II interferons. Read More

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http://dx.doi.org/10.1128/JVI.00526-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146705PMC
September 2018
3 Reads

Virus-Induced Anterior Uveitis (VIAU) in Immunocompromised Patients.

Ocul Immunol Inflamm 2018 ;26(5):807-817

a Grupo de Investigación en Neurociencias (NeURos), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario , Bogotá , Colombia.

Purpose: To describe the clinical characteristics, diagnosis, and treatment of VIAU in immunocompromised patients.

Methods: A critical review of literature was performed.

Results: Diagnosis and treatment of VIAU in immunocompromised patients may be a challenge due to atypical clinical-courses, severe presentations, and more frequent recurrences. Read More

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http://dx.doi.org/10.1080/09273948.2018.1483519DOI Listing
September 2018
1 Read

Cytomegalovirus Disease in HIV-infected Children-A Single-Centre Clinical Experience over 23 Years.

J Trop Pediatr 2018 Jun;64(3):215-224

Pediatric Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Background: Cytomegalovirus (CMV) results in significant morbidity and mortality in Human Immunodeficiency Virus (HIV)-infected individuals. There is paucity of literature on paediatric CMV disease, especially from developing countries.

Methods: A retrospective review of records of all HIV-infected children with evidence of CMV disease was done. Read More

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http://dx.doi.org/10.1093/tropej/fmx052DOI Listing
June 2018
4 Reads
0.857 Impact Factor

Development of a Reporter System to Explore MMEJ in the Context of Replacing Large Genomic Fragments.

Mol Ther Nucleic Acids 2018 Jun 22;11:407-415. Epub 2018 Mar 22.

Department of Ophthalmology, Justus-Liebig-University, Giessen 35392, Germany. Electronic address:

Common genome-editing strategies are either based on non-homologous end joining (NHEJ) or, in the presence of a template DNA, based on homologous recombination with long (homology-directed repair [HDR]) or short (microhomology-mediated end joining [MMEJ]) homologous sequences. In the current study, we aim to develop a model system to test the activity of MMEJ after CRISPR/Cas9-mediated cleavage in cell culture. Following successful proof of concept in an episomally based reporter system, we tested template plasmids containing a promoter-less luciferase gene flanked by microhomologous sequences (mhs) of different length (5, 10, 15, 20, 30, and 50 bp) that are complementary to the mouse retinitis pigmentosa GTPase regulator (RPGR)-ORF15, which is under the control of a CMV promoter stably integrated into a HEK293 cell line. Read More

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http://dx.doi.org/10.1016/j.omtn.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992787PMC
June 2018
5 Reads

Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infections.

Mol Vis 2018 18;24:379-394. Epub 2018 May 18.

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA.

Purpose: The purpose of this study was to determine whether the blood-retina barrier is compromised by choroidal murine cytomegalovirus (MCMV) infection, using electron microscopy.

Methods: BALB/c mice were immunosuppressed with methylprednisolone and monoclonal antibodies to CD4 and CD8. At several time points post-MCMV intraperitoneal inoculation, the eyes were removed and analyzed with western blotting and immunoelectron microscopy for the presence of MCMV early antigen (EA) and the host protein RIP3. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957546PMC
November 2018
6 Reads

Human Cytomegalovirus Productively Replicates in Undifferentiated Oral Epithelial Cells.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, USA

Human cytomegalovirus (HCMV) productive replication is most often studied in fibroblasts. , fibroblasts amplify viral titers, but transmission and pathogenesis require the infection of other cell types, most notably epithelial cells. , the study of HCMV infection of epithelial cells has been almost exclusively restricted to ocular epithelial cells. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00903-18
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http://dx.doi.org/10.1128/JVI.00903-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069213PMC
August 2018
16 Reads

Cytomegalovirus retinitis before and after treatment.

J Fr Ophtalmol 2018 May;41(5):477-479

Cabinet Lazrak d'ophtalmologie, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.jfo.2017.09.020DOI Listing