6,193 results match your criteria Retinal Vein Occlusion


The Use of Inner Retinectomy to Relieve Inner Retinal Foreshortening Causing Retinal Detachment in the Setting of Branch Retinal Vein Occlusion.

Case Rep Ophthalmol Med 2020 13;2020:8853425. Epub 2020 Jun 13.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.

A 61-year-old Japanese woman presented with impairment of her left vision due to macular schisis secondary to branch retinal vein occlusion. Her left vision was 20/50, and schisis was observed inferotemporally. She underwent phacoemulsification and aspiration, implantation of the intraocular lens, and removal of the epiretinal membrane and internal limiting membrane. Read More

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http://dx.doi.org/10.1155/2020/8853425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312967PMC

CENTRAL RETINAL VEIN OCCLUSION IN YOUNG PATIENTS: Clinical Characteristics and Prognostic Factors.

Retina 2020 Jun 26. Epub 2020 Jun 26.

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate the clinical characteristics and prognostic factors of young patients with central retinal vein occlusion (CRVO).

Methods: This retrospective cohort study involved treatment-naïve patients with CRVO. Medical records regarding basic demographics, predisposing factors, ocular characteristics, and treatments were reviewed and compared according to age at CRVO onset. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002872DOI Listing

Differential effect of obesity on the incidence of retinal vein occlusion with and without diabetes: a Korean nationwide cohort study.

Sci Rep 2020 Jun 29;10(1):10512. Epub 2020 Jun 29.

Department of Ophthalmology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.

We aimed to evaluate the association between obesity and the incidence of retinal vein occlusion (RVO) with and without diabetes mellitus (DM).This is a retrospective cohort study using Korean National Health Insurance System data. The participants were 23,061,531 adults older than 20 years who received a health examination at least once between 2009 and 2012, and all patients were observed for RVO development until 2015. Read More

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http://dx.doi.org/10.1038/s41598-020-67375-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324392PMC

Exploration of Oxygen-Induced Retinopathy Model to Discover New Therapeutic Drug Targets in Retinopathies.

Front Pharmacol 2020 11;11:873. Epub 2020 Jun 11.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Oxygen-induced retinopathy (OIR) is a pure hypoxia-driven angiogenesis model and the most widely used model for ischemic retinopathies, such as retinopathy of prematurity (ROP), proliferative diabetic retinopathy (PDR), and retinal vein occlusion (RVO). OIR model has been used to test new potential anti-angiogenic factors for human diseases. We have recently performed the most comprehensive characterization of OIR by a relatively novel mass spectrometry (MS) technique, sequential window acquisition of all theoretical fragment ion mass spectra (SWATH-MS) proteomics and used genetically modified mice strains to identify novel molecular drug targets in angiogenic retinal diseases. Read More

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http://dx.doi.org/10.3389/fphar.2020.00873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300227PMC

Comparison of intravitreal dexamethasone implant and anti-VEGF drugs in the treatment of retinal vein occlusion-induced oedema: a meta-analysis and systematic review.

BMJ Open 2020 Jun 28;10(6):e032128. Epub 2020 Jun 28.

Department of Ophthalmology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China

Objective: To compare the efficacy and safety of intravitreal dexamethasone (DEX) implant and anti-vascular endothelial growth factor (anti-VEGF) agents in the treatment of macular oedema secondary to retinal vein occlusion (RVO).

Design: Systematic review and meta-analysis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Data Sources: PubMed, Cochrane Library and registry were searched from inception to 10 December 2019, without language restrictions. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-032128DOI Listing

Twelve-year incidence of retinal vein occlusion and its trend in Korea.

Graefes Arch Clin Exp Ophthalmol 2020 Jun 26. Epub 2020 Jun 26.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea.

Purpose: To estimate the 12-year incidence and trends of clinically diagnosed retinal vein occlusion (RVO) in Korea.

Methods: This is a nationwide population-based retrospective study using the Korean national health claims database from 2002 to 2015. The study consisted of the entire Korean population based on the 2015 Census of Population. Read More

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http://dx.doi.org/10.1007/s00417-020-04811-8DOI Listing

Time-Frequency Analysis of Photopic Negative Response in CRVO Patients.

Semin Ophthalmol 2020 Apr 25;35(3):187-193. Epub 2020 Jun 25.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: The PhNR is driven by retinal ganglion cells (RGCs). Therefore, the function of RGCs could be objectively evaluated by analyzing the PhNR. The aim of this article is to determine the effect of central retinal vein occlusion (CRVO) on PhNR and RGCs performances. Read More

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http://dx.doi.org/10.1080/08820538.2020.1781905DOI Listing

Repeatability of measuring the vessel density in patients with retinal vein occlusion: An optical coherence tomography angiography study.

PLoS One 2020 25;15(6):e0234933. Epub 2020 Jun 25.

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.

Purpose: To determine the repeatability of superficial vessel density measurements using Spectral domain Ocular coherence tomography angiography(SD-OCTA) in patients diagnosed with retinal vein occlusion(RVO).

Design: Prospective observational study.

Subjects: Patients who visited our retinal clinic from August 2017 to August 2018, diagnosed with RVO were recruited for the study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234933PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316309PMC

Allogenic Adipose Tissue-Derived Stromal/Stem Cells and Vitamin D Supplementation in Patients With Recent-Onset Type 1 Diabetes Mellitus: A 3-Month Follow-Up Pilot Study.

Front Immunol 2020 2;11:993. Epub 2020 Jun 2.

Nutrology and Diabetes Department, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

To evaluate the short term safety and potential therapeutic effect of allogenic adipose tissue-derived stromal/stem cells (ASCs) + cholecalciferol in patients with recent-onset T1D. Prospective, phase II, open trial, pilot study in which patients with recent onset T1D received ASCs (1 × 10 cells/kg) and cholecalciferol 2000 UI/day for 3 months (group 1) and were compared to controls with standard insulin therapy (group 2). Adverse events, C-peptide (CP), insulin dose, HbA1c, time in range (TIR), glucose variability (continuous glucose monitoring) and frequency of CD4FoxP3+ T-cells (flow cytometry) were evaluated at baseline (T0) and after 3 months (T3). Read More

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http://dx.doi.org/10.3389/fimmu.2020.00993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280537PMC

Clinical characteristics of branch retinal vein occlusion with increased retinal haemorrhage during treatment for macular oedema.

Sci Rep 2020 Jun 24;10(1):10272. Epub 2020 Jun 24.

Department of Ophthalmology, Keimyung University Dongsan Medical Center, #1035 Dalgubeoldae-ro, Dalseo-gu, Daegu, 42601, Korea.

This study was performed to evaluate clinical characteristics of branch retinal vein occlusion (BRVO) patients with increased retinal haemorrhage during macular oedema (MO) treatment. Patients were divided into increased and non-increased retinal haemorrhage groups. The former group was sub-divided based on the degree of increase: < 50% or ≥ 50%. Read More

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http://dx.doi.org/10.1038/s41598-020-67395-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314739PMC

Prognostic Value of Hyperreflective Material on Visual Acuity in Treatment-Naïve BRVO.

Ophthalmic Surg Lasers Imaging Retina 2020 Jun;51(6):320-327

Background And Objective: To correlate between hyperreflective material (HRM) seen on optical coherence tomography (OCT) and visual outcomes in treatment-naïve acute branch retinal vein occlusion (BRVO).

Patients And Methods: Demographic and OCT features of patients with acute BRVO were analyzed retrospectively. OCT parameters noted were macular edema type, HRM presence and location, and outer retinal layer integrity. Read More

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http://dx.doi.org/10.3928/23258160-20200603-02DOI Listing

Retinal vein occlusion and chronic kidney disease: A meta-analysis.

Eur J Ophthalmol 2020 Jun 24:1120672120937669. Epub 2020 Jun 24.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objectives: We performed this meta-analysis to assess the correlation of retinal vein occlusion (RVO) and chronic kidney disease (CKD).

Methods: We searched PubMed, Embase, Web of Science and Cochrane Library for population-based studies reporting the CKD as associated factor to RVO, central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO). Then we pooled the data for analysis. Read More

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http://dx.doi.org/10.1177/1120672120937669DOI Listing

Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.

Nat Commun 2020 Jun 23;11(1):3173. Epub 2020 Jun 23.

Department of Pathology & Cell Biology; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.

Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after hypoxia-ischemia is a critical event in subsequent dysfunction of the blood-retina barrier, using a panel of interrelated ophthalmic in vivo imaging measures in a mouse model of retinal vein occlusion (RVO). Rapid nonapoptotic activation of caspase-9 and its downstream effector caspase-7 in endothelial cells promotes capillary ischemia and retinal neurodegeneration. Read More

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http://dx.doi.org/10.1038/s41467-020-16902-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311551PMC

Acute retinal necrosis following dexamethasone intravitreal implant (Ozurdex®) administration in an immunocompetent adult with a history of HSV encephalitis: a case report.

BMC Ophthalmol 2020 Jun 22;20(1):247. Epub 2020 Jun 22.

Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang, People's Republic of China.

Background: Dexamethasone intravitreal implants (0.7 mg) (Ozurdex®, Allergan Inc., Madison, NJ) are FDA approved for managing macular oedema (ME) of retinal vein occlusion (RVO). Read More

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http://dx.doi.org/10.1186/s12886-020-01514-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310153PMC
June 2020
1.075 Impact Factor

Chronic myelogenous leukemia presenting as central retinal vein occlusion.

Leuk Lymphoma 2020 Jun 22:1-4. Epub 2020 Jun 22.

Department of Medicine, Division of Hematology, Jewish General Hospital, McGill University, Montreal, Canada.

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http://dx.doi.org/10.1080/10428194.2020.1775203DOI Listing

Ocular hypertension and severe intraocular pressure elevation after posterior subtenon injection of triamcinolone acetonide for various diseases.

Int J Ophthalmol 2020 18;13(6):946-951. Epub 2020 Jun 18.

Department of Ophthalmology, National Taiwan University Hospital, Taipei 10002, Taiwan, China.

Aim: To evaluate and compare the incidences of ocular hypertension and severe intraocular pressure (IOP) elevation after posterior subtenon injection of triamcinolone acetonide (PSTA) for various diseases.

Methods: Totally 179 eyes that had received PSTA for diabetic macular edema (=108), pseudophakic cystoid macular edema (=20), branch retinal vein occlusion (=16), central retinal vein occlusion (CRVO, =14), choroidal neovascularization (=14) or noninfectious uveitis (=7) were retrospectively enrolled. The primary outcomes included ocular hypertension defined as an IOP>21 mm Hg, and severe IOP elevation defined as a rise of 10 mm Hg or more in IOP compared with baseline. Read More

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http://dx.doi.org/10.18240/ijo.2020.06.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270252PMC

Topical Triamcinolone Acetonide-Loaded Liposomes as Primary Therapy for Macular Edema Secondary to Branch Retinal Vein Occlusion: A Pilot Study.

J Ocul Pharmacol Ther 2020 Jun 17. Epub 2020 Jun 17.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan, Mexico.

To explore safety and therapeutic efficacy of a topical ophthalmic triamcinolone acetonide-loaded liposome formulation (TA-LF) as primary therapy in patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Twelve eyes of 12 patients with ME secondary to BRVO were exposed to a topical instillation of 1 drop of TA-LF (TA 0.2%) 6 times a day for 12 weeks to evaluate safety and efficacy. Read More

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http://dx.doi.org/10.1089/jop.2019.0143DOI Listing

Combination of Ranibizumab with macular laser for macular edema secondary to branch retinal vein occlusion: one-year results from a randomized controlled double-blind trial.

BMC Ophthalmol 2020 Jun 19;20(1):241. Epub 2020 Jun 19.

Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Background: It is not clear whether macular laser combined with anti-vascular endothelial growth factor (VEGF) can reduce the number of anti-VEGF injections in the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Our study aimed to investigate the effects of intravitreal ranibizumab with or without macular laser for ME secondary to BRVO and its associated number of anti-VEGF injections.

Methods: This is a prospective, randomized, double-blind, monocentric trial. Read More

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http://dx.doi.org/10.1186/s12886-020-01498-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304204PMC

Real-world outcomes with ranibizumab in branch retinal vein occlusion: The prospective, global, LUMINOUS study.

PLoS One 2020 18;15(6):e0234739. Epub 2020 Jun 18.

Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia.

Objective: To evaluate the effectiveness, safety, and treatment patterns of ranibizumab 0.5 mg in treatment-naïve patients with branch retinal vein occlusion (BRVO) enrolled in the LUMINOUS™ study.

Study Design: A 5-year, global, prospective, multicenter, observational, open-label study conducted in a clinical practice (real-world) setting at outpatient ophthalmology clinics that recruited 30,138 consenting adult patients from all approved indications for ranibizumab across 42 countries. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234739PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302470PMC

Neovascular glaucoma in patients with central retinal vein occlusion: A real-life study in the anti-VEGF era.

Acta Ophthalmol 2020 Jun 16. Epub 2020 Jun 16.

Karolinska Institutet, St. Erik Eye Hospital, Stockholm, Sweden.

Purpose: To investigate the characteristics and treatment patterns of patients developing a neovascular event (NE) in the anterior chamber secondary to central retinal vein occlusion (CRVO) in an ordinary clinical setting.

Methods: In this retrospective real-life study, data from 243 eyes presenting with CRVO during 2012-2013 were collected. Maximum follow-up was 5 years. Read More

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http://dx.doi.org/10.1111/aos.14500DOI Listing

A Multicenter, Cross-Sectional Study of the Incidence of Major Macular Diseases That Cause Visual Impairment and Require Therapeutic Intervention in Greece: The ADVICE Study.

Clin Ophthalmol 2020 25;14:1417-1426. Epub 2020 May 25.

Ophthalmological Clinic, University Hospital of Heraklion, Heraklion, Greece.

Purpose: This multicenter, epidemiological, cross-sectional study aimed to estimate the annual cumulative incidence of major macular diseases that cause visual impairment and require therapeutic intervention in the routine care of Greece.

Methods: The study was carried out between December 2012 and May 2015 in 20 ophthalmology clinics. Over a one-year recruitment period per study site, all treatment naïve adult patients newly diagnosed with wet age-related macular degeneration, visual impairment due to diabetic macular edema or macular edema secondary to retinal vein occlusion requiring therapeutic management and who had not been diagnosed or treated for the same disease in the past were enrolled after providing informed consent. Read More

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http://dx.doi.org/10.2147/OPTH.S240417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259461PMC

Deterioration of Retinal Blood Flow Parameters in Branch Retinal Vein Occlusion Measured by Doppler Optical Coherence Tomography Flowmeter.

J Clin Med 2020 Jun 13;9(6). Epub 2020 Jun 13.

Department of Ophthalmology, School of Medicine, Asahikawa Medical University, Asahikawa 078-8510, Japan.

Background: Doppler optical coherence tomography (DOCT) flowmeter can be used to measure retinal blood flow (RBF) parameters, including vessel diameter, blood velocity, and the absolute value of RBF within 2.0 s. We investigated the RBF parameters in eyes with branch retinal vein occlusion (BRVO) using a DOCT flowmeter. Read More

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http://dx.doi.org/10.3390/jcm9061847DOI Listing

Prediction of post-treatment retinal sensitivity by baseline retinal perfusion density measurements in eyes with branch retinal vein occlusion.

Sci Rep 2020 Jun 15;10(1):9614. Epub 2020 Jun 15.

Department of Ophthalmology, Shinshu University School of Medicine, Nagano, Japan.

In this study, we investigated the longitudinal correlation between macular sensitivity and perfusion density (PD) in retinas affected by branch retinal vein occlusion. Retinal sensitivity was measured using microperimetry and PD was measured by optical coherence tomography angiography. We also investigated the possibility that the PD, 1 month after anti-vascular endothelial growth factor (VEGF) treatment, is a predictor of retinal sensitivity after 1 year of successful macular oedema management with anti-VEGF. Read More

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http://dx.doi.org/10.1038/s41598-020-66708-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295767PMC

Clinical presentation and prognostic factors affecting surgical outcomes of secondary macular holes after retinal vein occlusions.

Int Ophthalmol 2020 Jun 12. Epub 2020 Jun 12.

Department of Vitreo-Retina, Aravind Eye Hospital, Madurai, India.

Purpose: To describe clinical presentation, morphological features and surgical outcomes of macular hole (MH) secondary to retinal vein occlusion (RVO).

Method: This prospective interventional study evaluated eight eyes with atypical MH (secondary to RVO) and data regarding medical management, pars plana vitrectomy, postoperative anatomical hole closure, visual acuity improvement, morphological features of hole were noted till the last follow-up.

Results: Eight eyes with full-thickness MH in an RVO eye were followed-up for a minimum period of 3 months postoperatively. Read More

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http://dx.doi.org/10.1007/s10792-020-01465-7DOI Listing

Real world evidence on 5661 patients treated for macular oedema secondary to branch retinal vein occlusion with intravitreal anti-vascular endothelial growth factor, intravitreal dexamethasone or macular laser.

Br J Ophthalmol 2020 Jun 12. Epub 2020 Jun 12.

Institute of Health Informatics, University College London, London, London, UK

Background/aims: Clinical trials suggest anti-vascular endothelial growth factor is more effective than intravitreal dexamethasone as treatment for macular oedema secondary to branch retinal vein occlusion. This study asks if 'real world' data from a larger and more diverse population, followed for a longer period, also support this conclusion.

Methods: Data collected to support routine care at 27 NHS (National Health Service) Trusts between February 2002 and September 2017 contained 5661 treatment-naive patients with a single mode of treatment for macular oedema secondary to branch retinal vein occlusion and no history of cataract surgery either during or recently preceding the treatment. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315836DOI Listing

A comparison of the effect of intravitreal dexamethasone implant on macular and branch retinal vein occlusion. A real life experience.

Eur J Ophthalmol 2020 Jun 12:1120672120934982. Epub 2020 Jun 12.

Department of Ophthalmology, Namik Kemal University School of Medicine, Namık Kemal University, Tekirdağ, Turkey.

Purpose: This study aimed to compare the effects of intravitreal dexamethasone (IVDx) implants on branch retinal vein occlusions (BRVOs) and macular vein occlusions (MVOs).

Methods: Seventeen consecutive patients with MVO and 18 patients with BRVO, whose foveal thicknesses were greater than 300 µm, were recruited for this study. BRVO and MVO patients were diagnosed by means of fundus fluorescein angiography. Read More

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http://dx.doi.org/10.1177/1120672120934982DOI Listing

Intravitreal conbercept for branch retinal vein occlusion induced macular edema: one initial injection versus three monthly injections.

BMC Ophthalmol 2020 Jun 11;20(1):225. Epub 2020 Jun 11.

Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210000, China.

Background: To compare the efficacy of one initial intravitreal injection of conbercept (IVC) versus three monthly IVCs in patients with macular edema (ME) after branch retinal vein occlusion (BRVO). Both options were followed by a pro re nata (PRN) retreatment regimen.

Methods: This study retrospectively investigated and followed 60 patients with acute ME secondary to BRVO for over a year. Read More

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http://dx.doi.org/10.1186/s12886-020-01494-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291449PMC

Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy.

Sci Rep 2020 Jun 9;10(1):9299. Epub 2020 Jun 9.

Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan.

Ischemic proliferative retinopathy (IPR), such as proliferative diabetic retinopathy (PDR), retinal vein occlusion and retinopathy of prematurity is a major cause of vision loss. Our previous studies demonstrated that periostin (PN) and tenascin-C (TNC) are involved in the pathogenesis of IPR. However, the interactive role of PN and TNC in angiogenesis associated with IPR remain unknown. Read More

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http://dx.doi.org/10.1038/s41598-020-66278-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283227PMC

Sex Differences in Presentation, Treatment Patterns, and Clinical Outcomes in Central Retinal Vein Occlusion.

Ophthalmic Surg Lasers Imaging Retina 2020 05;51(5):279-285

Background And Objective: To evaluate the impact of sex differences on the presenting features, treatment patterns, and clinical outcomes in patients with central retinal vein occlusions (CRVO).

Patients And Methods: This retrospective, longitudinal cohort study included 476 patients diagnosed with CRVO over a 7-year period. Charts were reviewed and clinical data were abstracted. Read More

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http://dx.doi.org/10.3928/23258160-20200501-05DOI Listing

Evaluation of the Initial Optical Coherence Tomography Parameters in Anticipating the Final Visual Outcome of Central Retinal Vein Occlusion.

J Curr Ophthalmol 2020 Jan-Mar;32(1):46-52. Epub 2020 Mar 23.

Department of Ophthalmology, Faculty of Medicine, Van Yuzuncu Yil University, Tusba, Van, Turkey.

Purpose: To evaluate the predictive and associated factors in determining the visual outcome in patients having central retinal vein occlusion (CRVO)-related macular edema (ME).

Methods: The charts of the patients who were treated due to CRVO-related visual disturbance were reviewed. The optical coherence tomography (OCT) images of eyes were analyzed, and disorganization of retinal inner layers (DRILs), ellipsoid zone (EZ) and external limiting membrane (ELM) disruption length, hyper-reflectivity of retinal inner layer (HRIL) existence, baseline and final visual acuity (VA), subfoveal thickness (SFT), subretinal fluid (SRF), and injection numbers were noted. Read More

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http://dx.doi.org/10.4103/JOCO.JOCO_47_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265274PMC

MEK Inhibitor-Associated Central Retinal Vein Occlusion Associated with Hyperhomocysteinemia and MTHFR Variants.

Ocul Oncol Pathol 2020 May 21;6(3):159-163. Epub 2019 Oct 21.

Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Background: Central retinal vein occlusion (CRVO) is a visually threatening event that has rarely been observed in patients taking MEK1/2 inhibitors and that may necessitate permanent discontinuation of a potentially efficacious therapy. We investigated the clinical characteristics of CRVO in patients on mitogen-activated protein kinase kinase (MEK) inhibition to better understand their predisposing factors and clinical course.

Case Series: This was a single-center, retrospective cohort study (between December 2006 and September 2018). Read More

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http://dx.doi.org/10.1159/000501155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250324PMC

The role of serum inflammation-based factors in Anti-VEGF treatment for macular edema secondary to retinal vein occlusion and its subtypes.

Ophthalmic Res 2020 Jun 5. Epub 2020 Jun 5.

Objective:To evaluate association between pretreatment inflammation-based factors and outcomes in patients with macular edema secondary to retinal vein occlusion and its subtypes after intravitreal ranibizumab or conbercept implant.

Methods: This retrospective observational study included patients who were diagnosed with macular edema secondary to retinal vein occlusion at the First Affiliated Hospital of Nanchang University between January 2017 and January 2019, and who subsequently received intravitreal anti-vascular endothelial growth factor treatment. Blood-based parameters were measured before treatment, and correlations between best-corrected visual acuity (BCVA) and each of three parameters-neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio- were analyzed to identify predictors of effective intravitreal injection treatment outcomes. Read More

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http://dx.doi.org/10.1159/000509171DOI Listing
June 2020
1.376 Impact Factor

Relationship between retinal blood flow and cytokines in central retinal vein occlusion.

BMC Ophthalmol 2020 Jun 5;20(1):215. Epub 2020 Jun 5.

Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

Background: We evaluated the relationship between retinal blood flow and aqueous humor levels of cytokines/growth factors in patients with central retinal vein occlusion (CRVO).

Methods: In an observational study, 64 eyes of 64 CRVO patients were examined before anti-vascular endothelial growth factor (VEGF) therapy. Blood flow was assessed in large vessels around and at the optic disk by determining the mean blur rate using laser speckle flowgraphy. Read More

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http://dx.doi.org/10.1186/s12886-020-01486-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273673PMC

Chorioretinal Anastomosis for Central Retinal Vein Occlusion: A Review of Its Development, Technique, Complications, and Role in Management.

Authors:
Ian L McAllister

Asia Pac J Ophthalmol (Phila) 2020 May-Jun;9(3):239-249

Lions Eye Institute, Center for Ophthalmology and Visual Science, University of Western Australia, Western Australia, Australia.

Treatments for central retinal vein occlusion (CRVO) have improved dramatically with the advent of intravitreal agents aimed at blocking the effects of the dominant hypoxia-induced upreglulated cytokine, which is vascular endothelial growth factor (VEGF). This cytokine breaks down the capillary endothelial barriers and is a major component of the macular edema in this condition. These treatments although impressive only address some of the sequelae of CRVO and have no effect on the underlying cause which is an obstruction to venous outflow leading to retinal blood flow stagnation and an elevation of the retinal central venous pressure (CVP). Read More

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http://dx.doi.org/10.1097/APO.0000000000000286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299219PMC

Contributing ocular comorbidity to end-of-life visual acuity in medically treated glaucoma patients, ocular hypertension and glaucoma suspect patients.

Eye (Lond) 2020 Jun 3. Epub 2020 Jun 3.

University Eye Clinic Maastricht, Maastricht, The Netherlands.

Aim: To assess the visual acuity at the end of life in glaucoma suspect patients, ocular hypertension, and patients treated for glaucoma and to find factors contributing to a reduced visual acuity in this cohort of deceased patients.

Methods: In a cohort of 3883 medically treated glaucoma patients, glaucoma suspect, or patients with ocular hypertension assembled in 2001-2004, 1639 were deceased. Patient data were collected from electronic and paper patient files. Read More

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http://dx.doi.org/10.1038/s41433-020-0991-0DOI Listing

Altered intrinsic functional connectivity of the primary visual cortex in patients with retinal vein occlusion: a resting-state fMRI study.

Quant Imaging Med Surg 2020 May;10(5):958-969

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang 330006, China.

Background: To investigate the differences of spontaneous functional connectivity (FC) of the primary visual cortex (V1) between patients with retinal vein occlusion (RVO) and healthy controls (HCs) using resting-state functional magnetic resonance imaging (rs-fMRI) data.

Methods: Twenty-one patients with RVO in total (11 males, 10 females) and 21 HCs similarly analogue in age and sex background were enrolled and inspected with rs-fMRI. The difference in FC of V1 between two groups were compared using two-sample t-test. Read More

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http://dx.doi.org/10.21037/qims.2020.03.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242310PMC

Ocular flare-up in patients with systemic lupus erythematosus following discontinuation of hydroxychloroquine.

Lupus 2020 Jul 2;29(8):987-992. Epub 2020 Jun 2.

Retina Service, Farabi Eye Hospital, Ophthalmology Department, Tehran University of Medical Sciences, Tehran, Iran.

In this report, we describe two patients with systemic lupus erythematosus (SLE) who manifested with posterior segment flare-up approximately three months after cessation of hydroxychloroquine (HCQ). They were stable systemically with no history of hypertension or nephropathy at the time of referral. Our first patient presented with bilateral retinal vein occlusion, while evidence of choroidal involvement such as vascular leakage and wedge-shaped filling delay was present in indocyanine green angiography of both patients. Read More

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http://dx.doi.org/10.1177/0961203320928409DOI Listing

A systematic review and meta-analysis to compare the efficacy of conbercept with ranibizumab in patients with macular edema secondary to retinal vein occlusion.

Medicine (Baltimore) 2020 May;99(21):e20222

Wenzhou Medical University, China.

Background: The objective of this review and meta-analysis is to investigate the efficacy of conbercept and ranibizumab, combined with or without laser photocoagulation, in patients with macular edema secondary to retinal vein occlusion (RVO-ME).

Methods: Several databases have been used to identify relevant publications. After screening, a meta-analysis was conducted to compare conbercept and ranibizumab with the support of RevMan 5. Read More

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http://dx.doi.org/10.1097/MD.0000000000020222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249991PMC

Clinical observation of Dan-Hong Hua-Yu oral solution in treating retinal vein occlusion.

Medicine (Baltimore) 2020 May;99(21):e20173

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University.

Introduction: Retinal vein occlusion refers to diseases with decreased vision, dilated tortuous retinal veins visible on the fundus, and retinal hemorrhage, edema, and osmosis distributed along the vein. There is still no ideal intervention to treat central retinal vein occlusion. This study plan to observe the efficacy of Dan-Hong Hua-Yu oral solution in treating non-ischemic retinal vein occlusion, in order to provide new treatment ideas. Read More

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http://dx.doi.org/10.1097/MD.0000000000020173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249849PMC

Fluctuations in Macular Thickness in Patients with Retinal Vein Occlusion Treated with Anti-Vascular Endothelial Growth Factor Agents.

Ophthalmol Retina 2020 May 29. Epub 2020 May 29.

Case Western Reserve University School of Medicine, Cleveland Ohio, USA; Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Purpose: To evaluate macular thickness fluctuations in patients with retinal vein occlusions (RVO) treated with anti-vascular endothelial growth factor (anti-VEGF) agents, and to assess whether patients with larger fluctuations have poorer visual outcomes.

Design: Retrospective cohort study PARTICIPANTS: Treatment-naïve patients with RVO followed over 12 months of treatment METHODS: From optical coherence tomography (OCT), central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT) were collected at baseline, 3, 6, 9, and 12 months, and standard deviations (SD) across 12 months were calculated. Mixed effects regression was performed to examine the relationship between macular thickness SD and 12-month visual acuity (VA). Read More

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http://dx.doi.org/10.1016/j.oret.2020.05.018DOI Listing

[Pseudophakic cystoid macular edema].

Ophthalmologe 2020 Jun;117(6):579-590

Augenklinik, Städtisches Klinikum Dessau, Akademisches Lehrkrankenhaus der Medizinischen Hochschule Brandenburg, Theodor Fontane, Dessau, Deutschland.

Pseudophakic cystoid macular edema (PCME) is still one of the most frequent causes of loss of vision after cataract surgery. Clinical PCME occurs after initial improvement of vision 2-10 weeks after surgery in 1-2% with secondary vision loss and biomicroscopically visible macular cysts. Alterations, which are often not associated with functional limitations, can frequently be seen with angiography and optical coherence tomography (OCT). Read More

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http://dx.doi.org/10.1007/s00347-020-01122-5DOI Listing

Central Retinal Vein Occlusion after Gastric Bypass Surgery.

Obes Surg 2020 May 27. Epub 2020 May 27.

Department of Ophthalmology, Centro Hospitalar de São João, Porto, Portugal.

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http://dx.doi.org/10.1007/s11695-020-04735-6DOI Listing

Perineuritis or infiltration of optic nerve sheath? A presentation of diffuse large B cell Gastric lymphoma.

Indian J Ophthalmol 2020 Jun;68(6):1212-1214

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India.

Optic perineuritis is an inflammatory disorder involving the optic nerve sheath. It is currently considered as a part of idiopathic orbital inflammatory disease which also includes dacryoadenitis, orbital myositis, superior orbital fissure, and cavernous sinus syndrome (Tolosa hunt syndrome). As it is idiopathic, it is considered a diagnosis of exclusion. Read More

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http://dx.doi.org/10.4103/ijo.IJO_711_19DOI Listing
June 2020
0.927 Impact Factor

Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion.

Invest Ophthalmol Vis Sci 2020 May;61(5):54

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Purpose: To evaluate the depth and pattern of retinal hemorrhage in acute central retinal vein occlusion (CRVO) and to correlate these with visual and anatomic outcomes.

Methods: Retinal hemorrhages were evaluated with color fundus photography and fluorescein angiography at baseline and follow-up. Snellen visual acuity (VA), central foveal thickness (CFT), extent of retinal ischemia, and development of neovascularization were analyzed. Read More

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http://dx.doi.org/10.1167/iovs.61.5.54DOI Listing

Optic disc granuloma with retinal vein occlusion- rare presentation of Neuro-ophthalmic Sarcoidosis.

QJM 2020 May 27. Epub 2020 May 27.

Department of Ophthalmology, Army College of medical Sciences & Base Hospital Delhi Cantt-110010.

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http://dx.doi.org/10.1093/qjmed/hcaa180DOI Listing

The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema.

Graefes Arch Clin Exp Ophthalmol 2020 May 26. Epub 2020 May 26.

Department of Ophthalmology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment.

Methods: Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. Read More

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http://dx.doi.org/10.1007/s00417-020-04759-9DOI Listing

[Blood, where no blood should be].

Ophthalmologe 2020 May 19. Epub 2020 May 19.

Augenärzte im Altstadt-Carree, Augenzentrum Osthessen, Dalbergstr. 22, 36037, Fulda, Deutschland.

Intraocular ischemia can lead to an overexpression of vascular endothelial growth factor (VEGF). This in turn can lead to neovascularization in the anterior and/or posterior segment of the eye, e.g. Read More

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http://dx.doi.org/10.1007/s00347-020-01118-1DOI Listing

Comment on "Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography".

Int J Ophthalmol 2020 18;13(5):848-850. Epub 2020 May 18.

Department of Ophthalmology, University of Medicine Cluj-Napoca 400014, Romania.

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http://dx.doi.org/10.18240/ijo.2020.05.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201355PMC

Changes in venous calibre during intra-vitreal therapy for central retinal vein occlusion.

Eye (Lond) 2020 May 15. Epub 2020 May 15.

University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1038/s41433-020-0951-8DOI Listing

Ophthalmic photographer virtual clinics in medical retina.

Int J Ophthalmol 2020 18;13(4):677-680. Epub 2020 Apr 18.

Department of Ophthalmology, University Hospitals of Leicester NHS Trust, Leicestershire, LE1 5WW, United Kingdom.

Aim: To determine whether ophthalmic photographers (OPs) can conduct virtual clinics (VCs) in medical retina appropriately and whether this increases clinic capacity.

Methods: Three OPs underwent a training programme to learn how to assess and manage macular edema secondary to diabetes or retinal vein occlusion. The 300 consecutive patients over a 7-month observation period in 2018 were assessed in VCs by both OPs and medical retina consultants. Read More

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http://dx.doi.org/10.18240/ijo.2020.04.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137717PMC