241,350 results match your criteria Retinal Detachment Tractional


Retinal Astrocytic Hamartoma- Ophthalmologic marker of Tuberous Sclerosis.

QJM 2018 Dec 12. Epub 2018 Dec 12.

All India Institute Of Medical Sciences, Department of Neurology, Rishikesh, Uttarakhand, India.

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December 2018

Neurofibromatosis Type 1 Vasculopathy Presenting as Impending Central Retinal Artery Occlusion.

J Neuroophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.

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December 2018

GEP100/ARF6 regulates VEGFR2 signaling to facilitate high glucose induced epithelial-mesenchymal transition and cell permeability in RPE cells.

Am J Physiol Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, China.

Background: Cell permeability and epithelial-mesenchymal transition (EMT) was found to be enhanced in diabetic retinopathy, and the aim of this study was to investigate the underlying mechanism.

Methods: ARPE-19 cell line or primary RPE cells were cultured under high or normal glucose conditions. Specific shRNAs were employed to knocked down ARF6, GEP100 or VEGFR2 in ARPE-19 or primary RPE cells. Read More

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December 2018

Basics on the use of acid-sensing ion channels' inhibitors as therapeutics.

Neural Regen Res 2019 Mar;14(3):395-398

North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA.

Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases such as stroke, inflammation, arthritis, cancer, and recently migraine. More interestingly, acid-sensing ion channels may explain the sex differences in pain between males and females. Read More

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Neuroinflammation as a target for glaucoma therapy.

Neural Regen Res 2019 Mar;14(3):391-394

Visual Neurophysiology and Neurophthalmology Research Unit, IRCCS G.B. Bietti Foundation, Roma, Italy.

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells and microglia) and the release of a plethora of anti- and pro-inflammatory cytokines, chemokines and reactive oxygen species - has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. Read More

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Sequence effect in the treatment of proliferative diabetic retinopathy with intravitreal ranibizumab and panretinal photocoagulation.

Eur J Ophthalmol 2018 Dec 12:1120672118812270. Epub 2018 Dec 12.

In-Patient Department 2, Affiliated Eye Hospital of Nanjing Medical University, Nanjing, China.

Purpose:: To compare the outcome of the sequence in the two treatments (intravitreal ranibizumab and panretinal photocoagulation) in high-risk proliferative diabetic retinopathy.

Methods:: This retrospective study included 35 patients with newly diagnosed high-risk proliferative diabetic retinopathy in 43 eyes; 18 (22 eyes) received intravitreal ranibizumab before panretinal photocoagulation (intravitreal ranibizumab+ group), while the other 17 (21 eyes) received panretinal photocoagulation before intravitreal ranibizumab (panretinal photocoagulation+ group). Each subject received three intravitreal ranibizumabs that were interleaved with three panretinal photocoagulations. Read More

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December 2018

Pediatric open-globe injury in a university-based tertiary hospital.

Eur J Ophthalmol 2018 Dec 12:1120672118818013. Epub 2018 Dec 12.

1 Department of Ophthalmology, King Abdulaziz University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background:: To investigate epidemiology, etiology, and outcomes after repair of pediatric open-globe injury.

Methods:: We retrospectively reviewed medical records of patients ⩽18 years who underwent primary open-globe repair.

Results:: A total of 213 patients were identified. Read More

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December 2018

Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.

Purpose: To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA).

Methods: Sixty-two children with OSAS (124 eyes; 5.94 ± 1. Read More

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December 2018

Intraocular lens dislocation: a novel in-situ scleral refixation technique using a 25 Gauge trocar in the anterior chamber.

BMJ Open Ophthalmol 2018 23;3(1):e000174. Epub 2018 Nov 23.

Dipartimento Neuromuscoloscheletrico e Organi di Sensi, Università degli Study di Firenze, Florence, Italy.

Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide.

Methods And Analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study. Read More

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November 2018

Assessing photoreceptor structure in patients with traumatic head injury.

BMJ Open Ophthalmol 2018 24;3(1):e000104. Epub 2018 Nov 24.

Department of Ophthalmology and Visual Sciences, University of WI - Madison, Madison, Wisconsin, USA.

Objective: Previous work using adaptive optics scanning light ophthalmoscopy (AOSLO) imaging has shown photoreceptor disruption to be a common finding in head and ocular trauma patients. Here an expanded trauma population was examined using a novel imaging technique, split-detector AOSLO, to assess remnant cone structure in areas with significant disruption on confocal AOSLO imaging and to follow photoreceptor changes longitudinally.

Methods And Analysis: Eight eyes from seven subjects with head and/or ocular trauma underwent imaging with spectral domain optical coherence tomography, confocal AOSLO and split-detector AOSLO to assess foveal and parafoveal photoreceptor structure. Read More

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November 2018

Factors Affecting the Outcome of Scleral Buckling Surgery for Primary Rhegmatogenous Retinal Detachment.

J Ophthalmol 2018 13;2018:9016302. Epub 2018 Nov 13.

MD Ophthalmology Resident, Bharatpur Eye Hospital, Bharatpur-10, 44207 Chitwan, Nepal.

Introduction: Scleral buckle surgery retains a special place in treatment of retinal detachment despite development of new and advanced vitreoretinal surgical techniques. The outcome of any retinal detachment surgery depends on correct selection of patient, type and nature of detachment, and the expertise. This study aims to evaluate various other parameters that determine the outcome of scleral buckle surgery. Read More

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November 2018

Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis.

J Ophthalmol 2018 13;2018:7361212. Epub 2018 Nov 13.

Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain.

Purpose: To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS).

Methods: A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. Read More

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November 2018

The Analysis of Correlative Factors of Visual Acuity with Intravitreal Conbercept Injection in Macular Edema Associated with Branch Retinal Vein Occlusion.

J Ophthalmol 2018 12;2018:7348153. Epub 2018 Nov 12.

Municipal Hospital of Qingdao City, Qingdao, China.

Purpose: To evaluate the correlative factors of best-corrected visual acuity (BCVA) with intravitreal conbercept injection in macular edema secondary to branch retinal vein occlusion (BRVO).

Methods: This is a self-controlled retrospective study. 35 eyes of 35 patients with macular edema secondary to BRVO were enrolled. Read More

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November 2018

Effects of Smoking on Outcomes of Antivascular Endothelial Growth Factor Therapy in Patients with Neovascular Age-Related Macular Degeneration Smoking and Anti-VEGF Therapy in nAMD.

J Ophthalmol 2018 12;2018:2353428. Epub 2018 Nov 12.

Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0114, Japan.

Purpose: To evaluate the effect of smoking on the outcome of antivascular endothelial growth factor (VEGF) therapy in patients with neovascular age-related macular degeneration (nAMD).

Methods: This retrospective case-control study included 64 eyes in 59 patients with treatment-naïve nAMD. Smoking habits were obtained from hospital records and patient recall. Read More

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November 2018

The Method of Silent Substitution for Examining Melanopsin Contributions to Pupil Control.

Front Neurol 2018 27;9:941. Epub 2018 Nov 27.

Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands.

The human pupillary light response is driven by all classes of photoreceptors in the human eye-the three classes of cones, the rods, and the intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin. These photoreceptor classes have distinct but overlapping spectral tuning, and even a monochromatic light with a wavelength matched to the peak spectral sensitivity of a given photoreceptor will stimulate all photoreceptors. The method of silent substitution uses pairs of lights ("metamers") to selectively stimulate a given class of photoreceptors while keeping the activation of all others constant. Read More

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November 2018

Mitochondrial Fission Is Required for Blue Light-Induced Apoptosis and Mitophagy in Retinal Neuronal R28 Cells.

Front Mol Neurosci 2018 27;11:432. Epub 2018 Nov 27.

Research Institute of Ophthalmology and Visual Sciences, Affiliated Eye Hospital of Nanchang University, Nanchang, China.

Light emitting diodes (LEDs) are widely used to provide illumination due to their low energy requirements and high brightness. However, the LED spectrum contains an intense blue light component which is phototoxic to the retina. Recently, it has been reported that blue light may directly impinge on mitochondrial function in retinal ganglion cells (RGCs). Read More

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November 2018

Novel codon 15 RHO gene mutation associated with retinitis pigmentosa.

Int Med Case Rep J 2018 20;11:339-344. Epub 2018 Nov 20.

Department of Ophthalmology, Federal Health Sciences University of Porto Alegre, Porto Alegre, Brazil,

Objective: To describe, in a multimodal way, a new RHO gene mutation with lysine-for-asparagine substitution in autosomal dominant retinitis pigmentosa.

Methods: Case report. Retrospective data analysis. Read More

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November 2018

Safety of high-dose intravitreal triamcinolone acetonide as low-cost alternative to anti-vascular endothelial growth factor agents in lower-middle-income countries.

Clin Ophthalmol 2018 26;12:2383-2391. Epub 2018 Nov 26.

Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.

Purpose: The purpose of this study was to evaluate the safety of high-dose intravitreal triamcinolone acetonide (IVTA) as affordable low-cost alternative to anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [anti-VEGF] agents) in lower-middle-income countries.

Patients And Methods: This was a retrospective interventional non-comparative case series. The study recruited patients who received 20 mg IVTA for treating various retinal and optic nerve diseases over the past 5 years. Read More

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November 2018

Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography.

Br J Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Purpose: To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA).

Methods: This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Read More

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December 2018

A Novel Variant of the FZD4 Gene in a Chinese Family Causes Autosomal Dominant Familial Exudative Vitreoretinopathy.

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

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December 2018
1 Read

Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle-aged Caucasians: the Northern Finland Birth Cohort Eye study.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle-aged Caucasians.

Methods: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi-automated computer-assisted program. Read More

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December 2018
1 Read

Future clinical applicability of optical coherence tomography angiography.

Clin Exp Optom 2018 Dec 11. Epub 2018 Dec 11.

Ocular Imaging Group, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Optical coherence tomography angiography (OCT-A) is an emerging technology that allows for the non-invasive imaging of the ocular microvasculature. Despite the wealth of observations and numerous research studies illustrating the potential clinical uses of OCT-A, this technique is currently rarely used in routine clinical settings. In this review, technical and clinical aspects of OCT-A imaging are discussed, and the future clinical potential of OCT-A is considered. Read More

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December 2018

Induction of CRMP-2 phosphorylation by CDK5 restricts the repair of damaged optic nerve.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.

Objective: To study the mechanism of collapsin response mediator protein-2 (CRMP-2) phosphorylation changes and cyclin-dependent kinase 5 (CDK5) expression after optic nerve injury.

Methods: Optic nerve injury rat models were constructed, the messenger RNA (mRNA) level of CRMP-2 in optic nerve tissues was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) after building models 0, 3, 7, and 14 days. The protein expression of CRMP-2, phospho-CRMP-2 (p-CRMP-2), and CDK5 were also determined by western blot analysis. Read More

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December 2018

RhoB antibody alters retinal vascularization in models of murine retinopathy.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

Neovascularization in cancer or retinopathy is driven by pathological changes that foster abnormal sprouting of endothelial cells. Mouse genetic studies indicate that the stress-induced small GTPase RhoB is dispensable for normal physiology but required for pathogenic angiogenesis. In diabetic retinopathy, retinopathy of prematurity (ROP) or age-related wet macular degeneration (AMD), progressive pathologic anatomic changes and ischemia foster neovascularization are characterized by abnormal sprouting of endothelial cells. Read More

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December 2018

Vitreous Wiping, a new technique for removal of vitreous cortex remnants during vitrectomy.

Acta Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: Unremoved vitreoschisis-induced vitreous cortex remnants (VCR) are associated with macular pathology. When present on the retinal periphery, they may play a role in proliferative vitreoretinopathy and retinal detachment after vitrectomy. Existing instruments for their removal involve substantial risk of iatrogenic retinal damage. Read More

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December 2018

Prenatal development of retina in buffalo (Bubalus bubalis).

Anat Histol Embryol 2018 Dec 10. Epub 2018 Dec 10.

Department of Veterinary Anatomy, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana, India.

The development of retina in Indian buffalo (Bubalus bubalis) has not been reported previously. The aim of the present study was therefore to report the major landmarks and the time course in the development of retina. Serial histological sections of Indian buffalo embryos and foetuses were used as group1 (<20. Read More

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December 2018
1 Read

[Pathophysiology of the glutamate and the glycine transporters: new therapeutic targets].

Rev Neurol 2018 Dec;67(12):491-504

Centro de Biologia Molecular Severo Ochoa. Universidad Autonoma de Madrid, Madrid, Espana.

Introduction: The amino acids glutamate and glycine, apart from their role in protein synthesis, are two fundamental neurotransmitters in the central nervous system of mammals. The first one is ubiquitous and is involved in excitatory pathways of the neocortex, the retina and the cerebellum, and the second is involved in inhibitory pathways of brain caudal areas. However, both share their way of acting by integrating into the functioning of glutamate receptors of the NMDA type fundamentals in the regulation of motor, sensory and cognitive systems. Read More

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December 2018
1 Read

Research Progress in MRI of the Visual Pathway in Diabetic Retinopathy.

Curr Med Sci 2018 Dec 7;38(6):968-975. Epub 2018 Dec 7.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

With an increasing incidence, diabetic retinopathy is one of the most important complications of diabetes mellitus (DM) and is also known as one of the major reasons of adult acquired blindness. It is widely accepted that the visual impairment of diabetic patients results from retinal microvascular changes. However, recent clinical experimental and neuroimaging studies suggest that the visual impairment of diabetic patients is also related to the pathophysiological changes of different parts of the visual pathway in diabetic retinopathy. Read More

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December 2018
1 Read

Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease.

J Mol Med (Berl) 2018 Dec 8. Epub 2018 Dec 8.

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and retinal ganglion cell death long term. Therefore, alternative treatments that target common upstream disease mechanisms are needed. Read More

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December 2018

Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5847-5853

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA).

Methods: Macular areas measuring 464 × 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Read More

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December 2018

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5836-5846

Allergan plc, Irvine, California, United States.

Purpose: DARPin molecules are a novel class of small proteins that contain engineered ankyrin repeat domain(s) and bind to target proteins with high specificity and affinity. Abicipar-pegol (abicipar), a DARPin molecule targeting vascular endothelial growth factor-A (VEGF-A), is currently under evaluation in patients with age-related macular degeneration. The pharmacodynamic properties of abicipar were characterized using in vivo and in vitro assays. Read More

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December 2018

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5824-5835

Department of Biology, University of Victoria, Victoria, British Columbia, Canada.

Purpose: Despite numerous studies associating Visual System Homeobox 1 (VSX1), with posterior polymorphous corneal dystrophy and keratoconus, its role in these diseases is unclear. Here we examine the pathogenicity of VSX1 missense mutations in vitro and in a mouse genetic model.

Methods: Vsx1 transcriptional repressor activity, protein stability, and subcellular localization activity, was examined using luciferase reporter-based assays, western blotting and immunolabeling, respectively, in transfected human embryonic kidney 293T cells. Read More

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December 2018

Early Loss of Vision Results in Extensive Reorganization of Plasticity-Related Receptors and Alterations in Hippocampal Function That Extend Through Adulthood.

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum, Germany.

Although by adulthood cortical structures and their capacity for processing sensory information have become established and stabilized, under conditions of cortical injury, or sensory deprivation, rapid reorganization occurs. Little is known as to the impact of this kind of adaptation on cellular processes related to memory encoding. However, imaging studies in humans suggest that following loss or impairment of a sensory modality, not only cortical but also subcortical structures begin to reorganize. Read More

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December 2018
1 Read

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.

Hum Mol Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. Structural changes in the macula are associated with many ocular diseases, including age-related macular degeneration (AMD) and glaucoma. Although macular thickness is a highly heritable trait, there are no prior reported genome-wide association studies (GWASs) of it. Read More

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December 2018

The inter-visit variability of retinal blood flow velocity measurements using retinal function imager (RFI).

Eye Vis (Lond) 2018 4;5:31. Epub 2018 Dec 4.

1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Xianlie Road 54, Guangzhou, 510060 China.

Background: To determine the inter-visit variability of retinal blood flow velocities (BFVs) using a retinal function imager (RFI) in healthy young subjects.

Methods: Twenty eyes of 20 healthy young subjects were enrolled. RFI imaging was performed to obtain the BFVs in retinal arterioles and venules in a field measuring 7. Read More

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December 2018

The effect of sildenafil on retinal blood velocity in healthy subjects.

Eye Vis (Lond) 2018 5;5:30. Epub 2018 Dec 5.

1Department of Ophthalmology, Edith Wolfson Medical Center, 62 Halochamim St, 58100 Holon, Israel.

Purpose: It has been suggested that Sildenafil may have beneficial therapeutic effects in the treatment of neurodegenerative disorders. The retinal circulation is of significant interest as a marker of cerebral vascular disease since the retinal and cerebral vasculatures share many morphological and physiological properties, yet only the retinal circulation can be directly visualized. Therefore, our aim was to assess the change induced by Sildenafil on retinal blood velocity. Read More

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December 2018

Cuticular drusen associated with aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy).

Int J Retina Vitreous 2018 5;4:44. Epub 2018 Dec 5.

1Vitreous Retina Macula Consultants of New York, 460 Park Ave., New York, NY 10022 USA.

Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes.

Case Presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination. Read More

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December 2018

High-resolution, in vivo multimodal photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy imaging of rabbit retinal neovascularization.

Light Sci Appl 2018 5;7:103. Epub 2018 Dec 5.

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105 USA.

Photoacoustic microscopy (PAM) is an emerging imaging technology that can non-invasively visualize ocular structures in animal eyes. This report describes an integrated multimodality imaging system that combines PAM, optical coherence tomography (OCT), and fluorescence microscopy (FM) to evaluate angiogenesis in larger animal eyes. High-resolution in vivo imaging was performed in live rabbit eyes with vascular endothelial growth factor (VEGF)-induced retinal neovascularization (RNV). Read More

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December 2018
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Imaging retinal melanin: a review of current technologies.

J Biol Eng 2018 4;12:29. Epub 2018 Dec 4.

1Morgridge Institute for Research, Madison, WI USA.

The retinal pigment epithelium (RPE) is essential to the health of the retina and the proper functioning of the photoreceptors. The RPE is rich in melanosomes, which contain the pigment melanin. Changes in RPE pigmentation are seen with normal aging and in diseases such as albinism and age-related macular degeneration. Read More

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December 2018

The Prohormone Proinsulin as a Neuroprotective Factor: Past History and Future Prospects.

Front Mol Neurosci 2018 26;11:426. Epub 2018 Nov 26.

3D Lab, Development, Differentiation and Degeneration, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CIB/CSIC), Madrid, Spain.

Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied in the field of endocrinology, the bioactivity of the proinsulin molecule itself has received much less attention. Insulin binds to isoforms A and B of the insulin receptor (IR) with high affinity. Read More

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November 2018

Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice.

Oxid Med Cell Longev 2018 8;2018:5489476. Epub 2018 Nov 8.

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, China.

Purpose: Oxidative stress is a common pathological condition for multiple retinal diseases. Hydrogen peroxide (HO) has been applied as an oxidative stress inducer for the studies. Here, we report the effect of HO exposure to the mouse retina and its underlying mechanism. Read More

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November 2018

Expanding the role of medical retina virtual clinics using multimodal ultra-widefield and optical coherence tomography imaging.

Clin Ophthalmol 2018 15;12:2337-2345. Epub 2018 Nov 15.

Newcastle Eye Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK,

Background: An increasingly elderly population with a corresponding increase in ophthalmic conditions has led to increased pressure on hospital eye services (HES). In this study, we evaluated the use of a medical retina virtual clinic (MRVC), which has expanded into assessing all new medical retina referrals, where the need for urgent treatment was not clear.

Methods: Retrospective analysis of all new patients who were seen in the MRVC between April 2016 and May 2018. Read More

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November 2018

Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy.

Clin Ophthalmol 2018 14;12:2323-2329. Epub 2018 Nov 14.

Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan,

Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.

Subjects And Methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Read More

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November 2018

A transcriptomics analysis of the Tbx5 paralogues in zebrafish.

PLoS One 2018 10;13(12):e0208766. Epub 2018 Dec 10.

Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America.

TBX5 is essential for limb and heart development. Mutations in TBX5 are associated with Holt-Oram syndrome in humans. Due to the teleost specific genome duplication, zebrafish have two copies of TBX5: tbx5a and tbx5b. Read More

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December 2018

[Comparación de la densidad capilar parafoveal entre sujetos sanos y diabéticos con y sin retinopatía].

Gac Med Mex 2018 ;154(Supp 2):S30-S35

Dirección de Investigación y Enseñanza, Hospital Juárez de México, Ciudad de México, México.

Background: Parafoveal capillary density changes have not been characterized in type 2 diabetics without retinopathy.

Objective: To compare parafoveal capillary density between healthy subjects, and diabetics with and without retinopathy.

Method: Observational, prospective, transversal and comparative study; subjects without diabetes (group 1), diabetics without retinopathy (group 2), with retinopathy (group 3) and with diabetic macular edema (group 4), without macular ischemia, were included. Read More

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January 2018

A two-year study of diffused retinal pigment epitheliopathy treated with half-dose photodynamic therapy guided by simultaneous angiography and optical coherence tomography.

Eye (Lond) 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, 200032, China.

Objectives: Diffused retinal pigment epitheliopathy (DRPE) is not necessarily the same as chronic central serous chorioretinopathy (CSC), but a severe subgroup under the umbrella of chronic CSC. This study was to evaluate the efficacy and safety of half-dose PDT treating DRPE.

Methods: A retrospective case series design was used. Read More

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December 2018

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Bone Marrow Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Read More

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December 2018

In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina.

Sci Rep 2018 Dec 7;8(1):17700. Epub 2018 Dec 7.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Retinal degenerative diseases, due to the lack of regeneration systems and self-renewable cells, often lead to visual impairment. Pax6 is a pleiotropic transcription factor and its expression level determines self-renewal status or differentiation of retinal cells. Here, we investigated the fate of simultaneous induction of retinal ganglion cell death and Pax6 overexpression in retro-differentiation of retinal cells and their commitment to re-enter into the cell cycle. Read More

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December 2018

Asian perspective of eye diseases.

Eye (Lond) 2018 Dec 7. Epub 2018 Dec 7.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

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December 2018