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Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):113-115

Background And Objective: To discuss the role of proportional reflux hydrodissection (PRH) during pars plana vitrectomy (PPV) in eyes with diabetic tractional retinal detachment (TRD).

Patients And Methods: In this retrospective study, records of patients with diabetic TRD involving the fovea undergoing PPV with the help of PRH between January 2015 to March 2017 were noted. PRH relies on the Constellation system's proportional reflux feature. Read More

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Instituto de la Visión-Hospital La Carlota, Montemorelos, Nuevo León, México

Purpose: To compare the effectiveness of intravitreal ziv-aflibercept (IVZ) to intravitreal bevacizumab (IVB) administered preoperatively to patients undergoing pars plana vitrectomy (PPV) for severe manifestations of proliferative diabetic retinopathy (PDR).

Design: Randomised clinical trial (RCT).

Methods: Two hundred and six patients with PDR-related complications requiring PPV were randomised into one of two treatment groups: Group A received IVZ (1. Read More

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Vitreo-retinal Unit, Manchester Royal Eye Hospital, Manchester, UK.

We report the case of a 32-year-old Afrocaribbean man with known stage 3 proliferative sickle-cell retinopathy who presented with a mixed picture of tractional and rhegmatogenous macula off detachment. He underwent left primary 25 g vitrectomy with silicone oil, delamination and endolaser photocoagulation under a general anaesthetic. He, however, presented 48 hours postoperatively with gross anterior segment ischaemia. Read More

J Ocul Pharmacol Ther 2019 Jan 22. Epub 2019 Jan 22.

Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, China.

Purpose: We compared the efficacies of intravitreal ranibizumab (IVR) and intravitreal conbercept (IVC) as the adjuvant pretreatments for vitrectomy with silicone oil infusion for tractional retinal detachment (TRD) secondary to proliferative diabetic retinopathy.

Methods: This retrospective study comprised 74 patients (79 eyes) who underwent vitrectomy with silicone oil tamponade for diabetic TRD. They received IVC (37 eyes) or IVR (42 eyes) at standard doses 3-5 days preoperatively and were followed up for ∼6 months. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 Jan;50(1):42-49

Background And Objective: To compare between trimanual and unimanual vitrectomy in complicated proliferative diabetic retinopathy (PDR).

Patients And Methods: A prospective, non-randomized, comparative study including patients with tractional retinal detachment (TRD), vitreous hemorrhage with TRD, and combined TRD with rhegmatogenous retinal detachment. The patients were allocated into two groups: the unimanual group with three-port vitrectomy and the trimanual group with added fourth sclerotomy, through which the endoillumination probe was guided by the assistant. Read More

Taiwan J Ophthalmol 2018 Oct-Dec;8(4):222-236

Department of Ophthalmology, The University of Hong Kong, Hong Kong.

In this review, we present a concise summary of the more commonly seen types of retinal detachments (RDs) that one can encounter in pediatric patients. A spectrum of diseases from rhegmatogenous RD in Stickler syndrome, Marfan syndrome, and choroidal coloboma to exudative RD in Coats disease, to tractional RD in persistent fetal vasculature, and combined RDs in familial exudative vitreoretinopathy are described with the management pearls for each. Read More

Taiwan J Ophthalmol 2018 Oct-Dec;8(4):216-221

Department of Ophthalmology, Kindai University Faculty of Medicine, Osaka, Japan.

Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. ROP screening and interventions (e.g. Read More

JAMA Ophthalmol 2019 Jan 10. Epub 2019 Jan 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Importance: Diabetic retinopathy is the leading cause of blindness in working-age adults. Studies have suggested that statins may reduce the risk of developing diabetic retinopathy.

Objective: To investigate the association between statin therapy and the development of diabetic retinopathy in patients with diabetes and dyslipidemia. Read More

J Cell Commun Signal 2019 Jan 3. Epub 2019 Jan 3.

Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Diabetic retinopathy (DR) is considered as a diabetes-related complication that can render severe visual impairments and is also a risk factor for acquired blindness in both developed as well as developing countries. Through fibrovascular epiretinal membranes (ERMs), this condition can similarly lead to tractional retinal detachment. Laboratory efforts evaluating the DR pathogenesis can be provided by ocular vitreous fluid and ERMs resulting from vitrectomy. Read More

Br J Ophthalmol 2018 Dec 20. Epub 2018 Dec 20.

Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Pars plana vitrectomy is a challenging, minimally invasive microsurgical procedure due to its intrinsic manoeuvres and physiological limits that constrain human capability. An important human limitation is physiological hand tremor, which can significantly increase the risk of iatrogenic retinal damage resulting from unintentional manoeuvres that affect anatomical and functional surgical outcomes. The limitations imposed by normal physiological tremor are more evident and challenging during 'micron-scale' manoeuvres such as epiretinal membrane and internal limiting membrane peeling, and delicate procedures requiring coordinated bimanual surgery such as tractional retinal detachment repair. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Dec;49(12):e256-e262

Background And Objective: To investigate the incidence, clinical features, and outcomes of patients with macular hole (MH) formation after pars plana vitrectomy (PPV) for diabetic tractional retinal detachment (TRD).

Patients And Methods: We conducted a retrospective review of all cases of PPV for diabetic TRD performed by a surgeon (DS) at a large county hospital between November 2013 and August 2016.

Results: Ninety consecutive eyes of 79 patients were included in this case series, of which four eyes developed MH, yielding an incidence of 4. Read More

Cesk Slov Oftalmol 2018 ;73(5-6):178-182

The review points to the issues of persistent hyaloid artery, more precisely to possible clinical features, the influence on visual functions and potential complications during intraocular surgeries. In professional journals we can find just few reviews regarding this rare deviation of the eye development, therefore we want to present our experience. The persistent hyaloid artery causes chronical local changes of eye background at both of our patients, retinal detachment and retinoschisis. Read More

Clin Ophthalmol 2018 14;12:2323-2329. Epub 2018 Nov 14.

Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan,

Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.

Subjects And Methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Read More

Am J Ophthalmol Case Rep 2019 Mar 10;13:22-24. Epub 2018 Nov 10.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, USA.

Purpose: We report an update on a recently published case of uncontrolled hypertension secondary to immunoglobulin A (IgA) nephropathy resulting in massive bilateral retinal and choroidal infarction.

Observations: In our previous report, we presented a 30-year old female with end-stage renal disease who complained of painless vision loss after many missed hemodialysis. The patient was found to be in hypertensive crisis resulting in massive retinal and choroidal infarction with severe vision loss in both eyes. Read More

Int J Retina Vitreous 2018 21;4:43. Epub 2018 Nov 21.

1Suita Tokushukai Hospital Eye Center, 21-1, Senriokanishi, Suita City, Osaka 565-0814 Japan.

Background: To report the multimodal imaging and histology of a case of metastatic esophageal cancer with vitreoretinal involvement resembling acute retinal necrosis (ARN) in a patient receiving systemic chemotherapy.

Case Presentation: A 69-year-old Japanese man with a history of stage 4 esophageal carcinoma, treated with three cycles of 5-fluorouracil (5-FU) and cisplatin (CDDP) chemotherapy as well as 30 sessions of radiation therapy, presented with new onset of blurry vision in the right eye (OD). Visual acuity was 20/200 OD. Read More

Pediatrics 2018 Dec;142(6)

This policy statement revises a previous statement on screening of preterm infants for retinopathy of prematurity (ROP) that was published in 2013. ROP is a pathologic process that occurs in immature retinal tissue and can progress to a tractional retinal detachment, which may then result in visual loss or blindness. For more than 3 decades, treatment of severe ROP that markedly decreases the incidence of this poor visual outcome has been available. Read More

Indian J Ophthalmol 2018 Dec;66(12):1751-1762

Department of Ophthalmology, Kittner Eye Center, University of North Carolina, Chapel Hill, NC, USA.

Twenty-five percent of diabetes-related vision loss stems from complications of proliferative diabetic retinopathy (PDR). Panretinal photocoagulation has been the preferred treatment of high-risk PDR for decades and more recently intravitreal injections of drugs that inhibit the actions of vascular endothelial growth factor have become popular. But despite these treatments PDR may progress uncontrollably to advanced pathologies such as traction retinal detachments (TRDs), combined traction/rhegmatogenous retinal detachments (TRD/RRDs), vitreous hemorrhages, rubeosis iridis, and traction maculopathies, which produce mild-to-severe loss of vision. Read More

Ophthalmic Genet 2018 Dec 8;39(6):754-758. Epub 2018 Nov 8.

a Retinal Consultants , Des Plaines , IL , USA.

Background: Loeys-Dietz syndrome (LDS) is a connective tissue disorder that has phenotypic overlap with Marfan syndrome. In LDS, the aortic root dissections can be more aggressive and occur at a younger age than Marfan syndrome.

Materials And Methods: Review of two cases. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Oct;49(10):e169-e170

A 62-year-old male underwent pars plana vitrectomy for diabetic tractional retinal detachment. Multiple pars plana cysts varying from 2 to 0.5 disc diameter size were noted intraoperatively. Read More

J Med Case Rep 2018 Oct 17;12(1):310. Epub 2018 Oct 17.

Opticlass, Coriolan Brediceanu no. 29, Timisoara, Romania.

Background: Eales' disease is a difficult to treat idiopathic form of retinal vasculitis. We present such a case with peculiar epidemiology in which the only efficient therapeutic approach in order to maintain functional vision was repeated intravitreal dexamethasone implants (Ozurdex®). To the best of our knowledge this is the first report of this kind in the literature. Read More

JAMA Ophthalmol 2018 Oct 11;136(10):e183507. Epub 2018 Oct 11.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Curr Eye Res 2018 Oct 12:1-7. Epub 2018 Oct 12.

a Department of Ophthalmology , Gachon University Gil Hospital , Incheon , Korea.

Purpose: To demonstrate the advantages and efficacy of an air-perfused membrane dissection to control intraoperative bleeding in 23-gauge sutureless vitrectomy for proliferative diabetic retinopathy with severe fibrovascular membranes. Meterials and Methods: A prospective, consecutive, interventional case series of 15 eyes that underwent air-perfused diabetic vitrectomy (air vitrectomy group) for removal of the membranes was compared with a retrospective, membrane-matched case series of 10 eyes that underwent conventional diabetic vitrectomy (conventional vitrectomy group). The main outcome measures were real vitrectomy time, intraoperative and postoperative complications, and anatomic and functional successes at the final examination. Read More

Br J Ophthalmol 2018 Sep 29. Epub 2018 Sep 29.

NIHR Biomedical Research Centre at Moorfields Eye Hospitals NHS Foundation Trust, University College London Institute of Ophthalmology, London, UK.

Aim: To assess the impact of deprivation on diabetic retinopathy presentation and related treatment interventions, as observed within the UK hospital eye service.

Methods: This is a multicentre, national diabetic retinopathy database study with anonymised data extraction across 22 centres from an electronic medical record system. The following were the inclusion criteria: all patients with diabetes and a recorded, structured diabetic retinopathy grade. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Sep;49(9):e102-e104

Background And Objective: Anti-vascular endothelial growth factor (VEGF) therapy is increasing in popularity for treatment of retinopathy of prematurity (ROP). Despite many technical benefits, issues remain prompting further investigation.

Patients And Methods: Retrospective case report and literature review. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Sep;49(9):674-679

Background And Objective: To report the association of morning glory syndrome (MGS) with peripheral retinal nonperfusion in pediatric patients with MGS.

Patients And Methods: The authors retrospectively analyzed the records of pediatric patients with MGS using fundus fluorescein angiography. The peripheral retinal vascular architecture was recorded and graded according to the severity of peripheral retinal nonperfusion. Read More

Retina 2018 Sep 1. Epub 2018 Sep 1.

Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan.

J Curr Ophthalmol 2018 Sep 21;30(3):276-279. Epub 2018 Jun 21.

Manchester Royal Eye Hospital, Manchester University Hospital NHS Foundation Trust, Manchester, UK.

Purpose: To demonstrate the effect of intravitreal bevacizumab (IVB) on the size and vascularity of the fibro-vascular complex with the optical coherence tomography angiography (OCTA) before pars plana vitrectomy (PPV).

Methods: Observational case series of three eyes with active diabetic fibro-vascular complex and tractional retinal detachment (TRD) who underwent IVB (1.25 mg/0. Read More

Microvasc Res 2019 03 23;122:136-145. Epub 2018 Aug 23.

R.S. Mehta Jain Department of Biochemistry and Cell Biology, KBRIVO, Vision Research Foundation, Chennai, India; Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, India. Electronic address:

Neovascularization in retina and choroid involves interplay of many cytokines and growth factors. Vascular endothelial growth factor (VEGF) being a pro-angiogenic molecule has been found to be high in aqueous and vitreous humour of patients with proliferative diabetic retinopathy (PDR). VEGF is also found in the fibroblast and retinal pigment epithelial cells (RPE) of choroidal neovascular (CNV) membranes isolated from patients. Read More

Int J Retina Vitreous 2018 9;4:31. Epub 2018 Aug 9.

3T Ophthalmics, Irvine, CA USA.

Background: To evaluate the efficacy of selective episcleral delivery of celecoxib formulated in a sustained-release episcleral exoplant on a model of retinal and choroidal neovascularization induced in rabbits by subretinal injection of matrigel combined with vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF).

Methods: Nine New Zealand white rabbits were randomly assigned to three groups (episcleral celecoxib exoplant, intravitreal bevacizumab injection and control group). The bFGF was mixed with matrigel at a concentration of 10 ug/0. Read More

Ophthalmic Surg Lasers Imaging Retina 2018 Aug;49(8):625-628

Exudative and tractional retinal detachments have been reported as late sequelae of retinopathy of prematurity (ROP). The authors report a case of unilateral retinal detachment in a 19-year-old patient with history of peripheral ablation for ROP in the contralateral eye. This late reactivation is likely due to persistent avascular retina producing constant low levels of vascular endothelial growth factor. Read More

Am J Ophthalmol Case Rep 2018 Sep 19;11:142-145. Epub 2018 Jul 19.

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan.

Purpose: To report a rare case of bilateral periphlebitis associated with a pineal germinoma.

Observations: A 17-year-old male teenager presented at a local clinic complaining of blurred vision in both eyes. The treating physician identified bilateral uveitis, and prescribed the patient with a local steroid treatment. Read More

Ophthalmology 2018 Aug 2. Epub 2018 Aug 2.

Retina Service, Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania. Electronic address:

Purpose: To compare anatomic and functional outcomes in eyes with proliferative diabetic retinopathy (PDR) that were lost to follow-up (LTFU) for more than 6 months after treatment with either intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) agents or panretinal photocoagulation (PRP).

Design: Retrospective cohort study.

Participants: Fifty-nine patients who were LTFU immediately after treatment for more than 6 months between September 2013 and September 2016. Read More

Ophthalmologica 2018 23;240(3):129-134. Epub 2018 Jul 23.

Eye & Ear University Hospital, Faculté de Médecine, Université Saint-Esprit de Kaslik, Naccache, Lebanon.

Purpose: To evaluate the risk factors for elevated intraocular pressure (IOP) after pars plana vitrectomy (PPV) with silicone oil injection (SOI).

Procedures: This prospective interventional study included 254 consecutive eyes receiving PPV with SOI.

Results: Elevated IOP developed in 48% of the eyes postoperatively. Read More

Retin Cases Brief Rep 2018 Jul 13. Epub 2018 Jul 13.

Associated Retinal Consultants, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan.

Purpose: We report a case of congenital toxoplasmosis associated with retinal detachment.

Methods: A 9-month-old white boy presented a unilateral tractional retina detachment associated with congenital toxoplasmosis retinochoroiditis.

Results: The diagnosis is supported by positive IgG (>400) for toxoplasmosis and intracranial calcification on magnetic resonance imaging, along with positive family history of Toxoplasma infection in the mother. Read More

J Glaucoma 2018 Oct;27(10):e151-e153

El Paso Eye Surgeons, El Paso, TX.

Purpose: To report a case of successful intraocular pressure (IOP) reduction following Cypass supraciliary stent implantation in a postvitrectomized eye filled with silicone oil and chronic angle-closure glaucoma.

Materials And Methods: This is a case report.

Results: A 19-year-old female with chronic angle-closure glaucoma underwent combined cataract extraction, goniosynechiolysis and Cypass supraciliary shunt implantation. Read More

Am J Ophthalmol Case Rep 2018 Sep 24;11:49-51. Epub 2018 May 24.

Weill-Cornell Medical Center, New York, NY, 10065, USA.

Purpose: To report on two cases of treatment-refractory juxtapapillary hemagioblastomas that were managed with intra-arterial bevacizumab delivered via the ophthalmic artery.

Observations: Case 1 is a 35 year-old man with juxtapapillary hemangioblastoma who continued to have progressive tractional retinal detachment, optic nerve neovascaularization and cystoid macula edema (CME) despite heavy prior treatment with intravitreal anti-vascular endothelial growth factor (VEGF) and steroid intravitreal injections and laser. Case 2 is a 41 year-old woman with juxtapapillary hemangioblastoma who had progressive tractional retinal detachment, CME and visually-threatening intraocular pressure elevation despite treatment with anti-VEGF injection and laser. Read More

JAMA Ophthalmol 2018 Jul;136(7):753-758

Department of Ophthalmology, University of Washington, Seattle.

Importance: Handheld spectral-domain optical coherence tomography (SD-OCT) can provide insights into the complex interactions occurring at the vitreoretinal interface in retinopathy of prematurity (ROP) to enhance our understanding of ROP pathology.

Objective: To characterize vitreous bands in premature infants with use of handheld SD-OCT.

Design, Setting, And Participants: Prospective cohort study conducted from July 7, 2015, to February 28, 2017, at 2 university-based neonatal intensive care units. Read More

Eye (Lond) 2018 09 23;32(9):1472-1477. Epub 2018 May 23.

Zarifa Aliyeva National Ophthalmology Centre, 32/15 Javadkhan str., Baku, AZ1114, Azerbaijan.

Purpose: To analyze the prevalence of residual subfoveal fluid (RSF) after pars plana vitrectomy in patients with proliferative diabetic retinopathy complicated by tractional detachment of the macula and the effect of RSF on the postoperative visual outcome.

Methods: This study was a prospective observational case study of the optical coherence tomography (OCT) records of 23 patients (24 eyes) with macula-off diabetic tractional retinal detachment (TRD) who underwent successful 23-gauge pars plana vitrectomy between July 2012 and December 2015.

Results: The prevalence of RSF on OCT examination was 100% at 1 and 2 months, 91. Read More

Eye (Lond) 2018 09 22;32(9):1449-1454. Epub 2018 May 22.

Vitreoretinal Service, Moorfields Eye Hospital, 162 City Rd, London, EC1V 2PD, UK.

Aims: To report anatomical and functional outcomes in patients with proliferative sickle retinopathy (PSR) who underwent 23-gauge (23G) and 20-gauge (20G) vitrectomy.

Methods: Retrospective consecutive case series of patients who underwent vitreoretinal intervention for complications of PSR between April 2009 and February 2015. Operations were performed at a tertiary referral centre, Moorfields Eye Hospital. Read More

Zhonghua Yan Ke Za Zhi 2018 Apr;54(4):270-276

Department of Ophthalmology, Peking Union Medical College Hospital, Beijing 100730, China.

To evaluate the efficacy of vitrectomy and etiological diagnosis in the treatment of fungal endophthalmitis. A retrospective survey was done on the clinical manifestation, etiological diagnosis and treatment efficacy of 15 patients (15 eyes) who had been diagnosed with fungal endophthalmitis at the inpatient department of Peking Union Medical College Hospital during 2002-2015. A total of 15 eyes of 15 patients, 3 male and 12 female patients, were included in this study. Read More

Clin Ophthalmol 2018 16;12:733-738. Epub 2018 Apr 16.

Department of Ophthalmology, Sakura Medical Center of Toho University, Shimoshizu, Sakura, Japan.

Purpose: We retrospectively reviewed patients with postoperative neovascular glaucoma (NVG) after vitrectomy for proliferative diabetic retinopathy to investigate how variables assessed before, during, and after vitrectomy are associated with the requirement for filtration surgery.

Patients And Methods: The subjects in this retrospective, observational, comparative study were 55 consecutive patients (61 eyes) who underwent vitrectomy for proliferative diabetic retinopathy at Toho University Sakura Medical Center between December 2011 and November 2016, were followed up for at least 6 months after surgery, and developed NVG within 2 years after surgery. They comprised 44 men and 11 women of mean age 52. Read More

Technol Health Care 2018 ;26(3):483-498

Department of Mechanical Engineering, Kyushu University, Fukuoka, Japan.

This study was aimed at investigating the role of IVI angle on the induced stresses and deformations among the components of the eye. Thereafter, the most optimal angle of IVI to minimize the complications of post IVI at the injection site on a basis of the computed stresses via a Fluid-Structure Interaction (FSI) computational model was proposed. IntraVitreal Injection (IVI) is broadly employed as a principal treatment of vascular vitro-retinal diseases. Read More

J Pediatr Ophthalmol Strabismus 2018 Jul 1;55(4):270-274. Epub 2018 May 1.

Purpose: To report the clinical profiles, etiologies, treatment modalities, and outcomes for Eales disease in patients younger than age 16 years in India.

Methods: Retrospective review of medical records of patients with Eales disease who had a minimum 5-year follow-up period.

Results: A total of 25 eyes of 13 patients were included. Read More

Arq Bras Oftalmol 2018 Jan-Feb;81(1):63-65

Henry C. Witelson Ocular Pathology Laboratory, McGill University. Montreal, Canada.

This study reports the first case of intravitreal angiostrongyliasis in South America treated with posterior worm removal via pars plana vitrectomy. This was a retrospective, observational case study. Data from medical charts, wide-field digital imaging, ocular ultrasound, and visual evoked potential studies were reviewed. Read More

Eye (Lond) 2018 06 15;32(6):1093-1098. Epub 2018 Feb 15.

Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, University Federico II, Via Pansini 5, Naples, 80131, Italy.

Objectives: To evaluate the use of a three-dimensional heads-up microscope (3DM) during 25-gauge pars plana vitrectomy (PPV) compared with a traditional ophthalmic microscope (TM) in terms of efficacy, safety, and teaching and learning satisfaction.

Methods: Prospective comparative interventional study. Fifty eyes affected by one of the following diseases: rhegmatogenous or tractional retinal detachment, epiretinal membrane, full-thickness macular hole, vitreous hemorrhage, or dropped lens. Read More

J Med Case Rep 2018 Feb 12;12(1):36. Epub 2018 Feb 12.

Royal Eye Infirmary, Level 3, Derriford Hospital, Plymouth, PL6 8DH, UK.

Background: Proliferative diabetic retinopathy leading to vitreous hemorrhage, tractional retinal detachment, and neovascular glaucoma is a major cause of severe sight impairment in adults of working age worldwide. Neovascular glaucoma occurs in 2.5% of patients with proliferative diabetic retinopathy, which is difficult to treat and often leads to blindness. Read More

BMC Ophthalmol 2018 Feb 8;18(1):34. Epub 2018 Feb 8.

Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science Clinical College of Ophthalmology, Tianjin Medical University , No. 4 Gansu Rd, Heping District, Tianjin, 300020, China.

Background: The recent advancement in the management of chronic renal failure (CRF) has significantly increased the longevity of the patients, which increase the incidence of severe vitreoretinopathy. The vitrectomy is highly risky in this particular group of patients due to their systemic comorbidity. The timing surgical intervention is usually delayed because of the systemic conditions. Read More

Retina 2018 Sep;38 Suppl 1:S134-S145

Shroff Eye Centre, New Delhi, India.

Purpose: To evaluate the visual and anatomical outcomes and safety of bimanual microincision vitreous surgery for severe proliferative diabetic retinopathy.

Methods: Retrospective review of 315 eyes of 282 patients who underwent 23-gauge or 25-gauge pars plana vitrectomy with bimanual membrane dissection for diabetic tractional detachment from January 2007 to September 2016. Minimum follow-up was 3 months, and the average duration of follow-up was 23 months (range 3-100 months; median 15 months). Read More

Ophthalmology 2018 May 1;125(5):691-700. Epub 2018 Feb 1.

Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.

Purpose: Comparison of the efficacy of ranibizumab (RBZ) 0.5 mg intravitreal injections plus panretinal photocoagulation (PRP) versus PRP alone in the regression of the neovascularization (NV) area in subjects with high-risk proliferative diabetic retinopathy (HR-PDR) over a 12-month period.

Design: Prospective, randomized, multicenter, open-label, phase II/III study. Read More

Retina 2018 09;38 Suppl 1:S110-S120

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.

Purpose: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications.

Methods: In this prospective study, we analyzed a subgroup of patients with proliferative diabetic retinopathy complications who required vitrectomy and who were imaged by the research swept-source microscope-integrated optical coherence tomography system. In near real time, images were displayed in stereo heads-up display facilitating intraoperative surgeon feedback. Read More