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Case Rep Ophthalmol 2022 Jan-Apr;13(1):243-246. Epub 2022 Apr 4.

Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Triamcinolone acetonide (TA) is a widely used corticosteroid for various ophthalmological indications. We report a case of a 27-year-old female presented with upper eyelid edema and punctate corneal erosions and haze of the left eye, 1 week after pars plana vitrectomy with silicone oil (SO) tamponade and intravitreal TA for diabetic tractional retinal detachment. The condition persisted despite topical and systemic therapy. Read More

Retina 2022 May 12. Epub 2022 May 12.

Department of Ophthalmology, Balıkesir University Medicine Faculty, Balıkesir, TURKEY.

Purpose: To evaluate the effect of internal limiting membrane (ILM) peeling on anatomical and functional results in pars plana vitrectomy (PPV) performed eyes with tractional retinal detachment affecting the macula due to diabetes mellitus (DM).

Methods: Patients without ILM peeling were considered as Group 1, and with ILM peeling were considered as Group 2. The main outcomes were the best-corrected visual acuity (BCVA) at 6 months, and the rate of epiretinal membrane (ERM) formation within 6 months. Read More

J Glaucoma 2022 May 10. Epub 2022 May 10.

Ophthalmology department, Mohamed Taher Maamouri hospital, Faculty of Medicine Tunis El Manar, Tunisia.

Purpose: To assess the efficiency and safety of MicroPulse® Transscleral Laser Therapy (TLT) in the management of silicone oil-induced glaucoma.

Methods: A prospective case series of 33 eyes with uncontrolled silicone oil-induced glaucoma was enrolled at the department of ophthalmology of Mohamed Taher Maamouri Hospital, Nabeul, Tunisia. Patients were treated with MicroPulse TLT using the IRIDEX Cyclo G6® Glaucoma Laser System with the MicroPulse P3® fiberoptic handheld probe. Read More

Ophthalmic Surg Lasers Imaging Retina 2022 05 1;53(5):293-296. Epub 2022 May 1.

Homozygous protein C deficiency is a rare hypercoagulability disorder. This study describes the ocular manifestations and the genetic background in a family with two affected children. This is a retrospective review of ophthalmic examinations, investigations, genetic testing, and blood work-up of two children with homozygous protein C deficiency from a single family. Read More

Zhonghua Yi Xue Za Zhi 2022 May;102(18):1389-1393

Department of Ophthalmology & Clinical Centre of Optometry, Peking University People's Hospital, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing 100044, China.

To identify prognostic factors for revitrectomy in patients who underwent pars plana vitrectomy (PPV) for complications with proliferative diabetic retinopathy (PDR). This study was a retrospective case-control study. Clinical data of PDR patients (290 eyes) at Peking University People's Hospital from December 2019 to December 2020 were retrospectively collected. Read More

Ophthalmic Surg Lasers Imaging Retina 2022 04 1;53(4):228-232. Epub 2022 Apr 1.

Familial exudative vitreoretinopathy (FEVR) is a rare hereditary vitreoretinopathy resulting from mutations in the signaling pathway leading to abnormalities in fetal retinal vasculogenesis, angiogenesis, and retinal vascular maintenance. Severe FEVR may result in congenital retinal detachment resembling Norrie disease. The authors report the first case of planned preterm delivery and treatment of a patient with severe FEVR from biallelic mutations whose siblings had congenital tractional retinal detachments with light perception vision outcomes after conventional care. Read More

Saudi J Ophthalmol 2021 Apr-Jun;35(2):149-151. Epub 2022 Feb 18.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Macular schisis is the splitting of the inner retinal layers at macula, with or without associated detachment. The acquired form of macular schisis is frequently associated with optic disc pit maculopathy, although it could be accompanied by several conditions such as tractional maculopathies, cystoid macular edema, veno-occlusive disease, and shaken baby syndrome. However, a small number of cases of retinoschisis without optic disc pit have been reported elsewhere. Read More

Oman J Ophthalmol 2022 Jan-Apr;15(1):89-91. Epub 2022 Mar 2.

Department of Pediatric Ophthalmology, Ophthalmology Service - SAMIC Pediatric Hospital "Prof. Dr. JP Garrahan", Buenos Aires, Argentina.

A 6-year-old girl with visual impairment in the right eye (OD) was referred for an eye evaluation. The fundus of the OD showed a fibrotic orange endophytic lesion located adjacent to the optic disc. In retinal optical coherence tomography, a local tractional retinal detachment and choroidal neovascular membrane were observed together also with the presence of subretinal fluid. Read More

Surv Ophthalmol 2022 Mar 31. Epub 2022 Mar 31.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Vagelos College of Physicians and Surgeons, New York City, NY, USA. Electronic address:

Myopic traction maculopathy (MTM), one of the complications of pathologic myopia, is a spectrum of pathological conditions that are attributed to tractional changes in the eye characterized by retinoschisis, lamellar or full thickness macular hole, and foveal retinal detachment. Considering the global public health burden of MTM and pathologic myopia, it is important to understand these sight-threatening complications and their associations. We conducted an evidence-based review of the prevalence and natural history of MTM and associated risk factors. Read More

Am J Ophthalmol Case Rep 2022 Jun 4;26:101467. Epub 2022 Mar 4.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Purpose: To report a rare case of Aicardi syndrome presenting with concurrent peripheral retina nonperfusion with 360-degree neovascularization in the right eye and stalk tissue with a peripapillary fibrovascular membrane and tractional retinal detachment (TRD) in the left eye.

Observations: A one-month-old girl was referred for an ophthalmic evaluation to confirm the diagnosis of Aicardi syndrome due to abnormal brain magnetic resonance imaging. A 360-degree circumferential peripheral avascular retina with extensive neovascularization was present in the right eye. Read More

J Clin Med 2022 Mar 14;11(6). Epub 2022 Mar 14.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.

Purpose: To investigate the characteristics of macular outward scleral height (MOSH) in different grades of myopic tractional maculopathy (MTM) and explore the risk factors for MTM.

Methods: A total of 188 eyes (188 participants) with high myopia were divided into the no MTM (nMTM) group and the MTM group, which was further graded into foveoschisis, foveal detachment, full-thickness macular hole, and macular hole with retinal detachment. Swept-source optical coherence tomography was used to measure the MOSH. Read More

Sci Rep 2022 03 23;12(1):4992. Epub 2022 Mar 23.

Department of Ophthalmology, Changhua Christian Hospital, No. 135, Nanxiao Street, Changhua City, Taiwan.

Pharmacoepidemiol Drug Saf 2022 Jun 15;31(6):652-660. Epub 2022 Mar 15.

Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose: This study aims to assess the effect of statins on progression from nonproliferative diabetic retinopathy (NPDR) to vision-threatening diabetic retinopathy (VTDR), proliferative diabetic retinopathy (PDR) or diabetic macular edema (DME).

Methods: Two cohort studies using a U.S. Read More

Am J Ophthalmol Case Rep 2022 Mar 3;25:101399. Epub 2022 Feb 3.

Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.

Am J Ophthalmol Case Rep 2022 Mar 31;25:101388. Epub 2022 Jan 31.

Molecular Surgery Laboratory, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, 94304, USA.

Purpose: Acanthamoeba chorioretinitis is a rare manifestation of the parasitic infection, and reported cases often result in enucleation. Surgical removal of Acanthamoeba chorioretinitis has not been previously described. We report a surgical case of Acanthamoeba chorioretinitis spread from keratitis that ultimately resulted in a disease-free outcome. Read More

Am J Ophthalmol Case Rep 2022 Mar 3;25:101305. Epub 2022 Feb 3.

Stein Eye Institute, Department of Ophthalmology, UCLA, USA.

Purpose: We report the first known case of eye findings associated with a Fas-associated protein with death domain (FADD) gene mutation, an exceedingly rare entity.

Observations: A 7-year-old boy was referred for decreased vision and eye examination revealed cystoid macular edema and peripheral retinal ischemia in both eyes and progression to tractional retinal detachment in the right eye.

Conclusions And Importance: This case suggests that baseline and annual ophthalmic screening may be beneficial in individuals with FADD mutations. Read More

Indian J Ophthalmol 2022 Mar;70(3):1074

Vitreoretina Service, Disha Eye Hospitals; Occuloplasty and Comprehensive Ophthalmology, Disha Eye Hospitals, Barrackpore, Kolkata, West Bengal, India.

Background: Falciform folds are congenital tractional retinal folds due to strong contractile forces and hyperextensibility of retina resulting in temporal dragging of the macula and often associated with familial exudative vitreoretinopathy and retinal detachment (RD). Retinologists are reluctant to treat these entities in view of their poor visual recovery.

Purpose: To describe a novel surgical technique to unfold the falciform folds. Read More

Front Med (Lausanne) 2022 11;9:833519. Epub 2022 Feb 11.

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Purpose: To describe the clinical characteristics, treatments, and prognosis of subretinal proliferation (SRP) in proliferative diabetic retinopathy (PDR) patients.

Methods: A total of 184 patients (221 eyes) who received vitrectomy for PDR between 2018 and 2021 were retrospectively reviewed. Patients with SRP were further evaluated. Read More

Discov Med 2021 Jul-Aug;32(165):13-22

Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and also the main cause of visual impairment or even blindness in diabetic patients. Retinal fibrosis is the leading character of proliferative diabetic retinopathy, which often brings about diabetic tractional retinal detachment. Poly(ADP-ribose) polymerase-1) is the most extensively studied nuclear enzyme of the PARP superfamily, which controls major functions on chromatin, DNA damage repair, and transcriptional regulation. Read More

Curr Eye Res 2022 Apr 5:1-13. Epub 2022 Apr 5.

Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.

Purpose: The biomechanical properties of the vitreous humor and replication of these properties to develop substitutes for the vitreous humor have rapidly become topics of interest over the last two decades. In particular, the behavior of the vitreous humor as a viscoelastic tissue has been investigated to identify its role in a variety of processes related to biotransport, aging, and age-related pathologies of the vitreoretinal interface.

Methods: A thorough search and review of peer-reviewed publications discussing the biomechanical properties of the vitreous humor in both human and animal specimens was conducted. Read More

BMC Ophthalmol 2022 Feb 10;22(1):63. Epub 2022 Feb 10.

Department of Ophthalmology of The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, 410011, Changsha, China.

Background: Intravitreal injection of anti-vascular endothelial growth factor (VEGF) has become first line therapy for diabetic macular edema. This study evaluated the efficacy and safety of intravitreal injection of Ranibizumab (IVR) as pre-treatment for pars plana vitrectomy in proliferative diabetic retinopathy (PDR) patients with vitreous hemorrhage.

Methods: This pilot randomized controlled trial included 48 eyes with vitreous hemorrhage resulting from active PDR. Read More

Ophthalmol Retina 2022 Feb 1. Epub 2022 Feb 1.

Institute for Vision Research and Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa. Electronic address:

Purpose: To characterize the poorly understood phenomenon of whitish outer retinal spots that occasionally appear in retinal detachment (RD).

Design: Retrospective, consecutive case series.

Subjects: Patients with RDs that had ophthalmoscopically visible whitish outer retinal spots. Read More

Indian J Ophthalmol 2022 Feb;70(2):483-489

Department of Vitreoretina and Ocular Oncology, Sankara Eye Hospital, Bengaluru, Karnataka, India.

Purpose: Coats' disease is associated with poor outcomes, and there are limited studies on long-term outcomes of Coats' disease. The purpose of our study is to identify various predictive factors to help in prognosticating the treatment outcomes in advanced Coats' disease in children.

Methods: This is a retrospective case series from a single tertiary eye care center of children (<18 years) diagnosed with coat's disease. Read More

Indian J Ophthalmol 2022 02;70(2):470-471

Department of Retina and Vitreous Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Indian J Ophthalmol 2022 Feb;70(2):465-470

Vitreoretina Services, Narayana Nethralaya, Bangalore, Karnataka, India.

Purpose: To compare multicolor imaging (MCI) with Optos color fundus photography (OCFP) for the evaluation of morphology and extent of preretinal membranes in diabetic tractional retinal detachments (TRD).

Methods: In this retrospective study, 30 eyes with diabetic TRDs were imaged using the MCI feature of the Heidelberg Spectralis Spectral-domain optical coherence tomography (SD-OCT) and color photo using the Optos Daytona ultra-widefield fundus camera. Two investigators independently graded and determined the agreeability between the two modalities with respect to the extent of the TRD and preretinal membranes on the SD-OCT B-scan images. Read More

Medicine (Baltimore) 2021 Dec;100(48):e27793

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.

Rationale: Proliferative diabetic retinopathy (PDR) may lead to severe visual impairment, and visual field (VF) loss in such patients has been reported. Vitrectomy is performed in PDR cases complicated with either vitreous hemorrhage or tractional retinal detachment to restore their visual acuity. However, its effect on VF defects is limited in data. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Jun 14;260(6):1899-1906. Epub 2022 Jan 14.

Department of Ophthalmology, Kocaeli University Medical School, 41001, İzmit, Kocaeli, Turkey.

Purpose: In diabetic retinopathy patients, intravitreal bevacizumab (IVB) injections are widely used to facilitate dissection of retinal fibrovascular membranes during surgery, reduce the rate of perioperative hemorrhage, and prevent recurrent neovascularization. Previous studies have shown that IVB may worsen fibrosis and thereby impair vision. The aim of this study was to determine which markers are associated with fibrosis. Read More

Beyoglu Eye J 2021 27;6(3):243-248. Epub 2021 Sep 27.

Turkiye Hospital, Istanbul, Turkey.

Objectives: This study evaluated the anatomical and functional results of 23-G transconjunctival sutureless vitrectomy (TSV) in diabetic retinopathy (DR) patients with a variety of vitreoretinal diseases.

Methods: Consecutive patients who underwent 23-G TSV for complications of DR were evaluated retrospectively. The primary outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP), and intraoperative and postoperative complications. Read More

Beyoglu Eye J 2021 10;6(1):49-53. Epub 2021 Feb 10.

Department of Ophthalmology, Etiler World Eye Hospital, Istanbul, Turkey.

Objectives: This study was designed to evaluate the reliability of preoperative ultrasonography (USG) to detect tractional retinal detachment (TRD) in vitreous hemorrhage (VH) due to proliferative diabetic retinopathy.

Methods: The medical records of patients with VH who underwent A- and B-scan ultrasonography prior to a vitrectomy between November 2016 and May 2017 were reviewed in this retrospective study. All of the patients were assessed using USG before surgery with 4-quadrant transverse and 1-quadrant longitudinal scans whether to determine if the VH was accompanied by TRD. Read More

Int J Retina Vitreous 2022 Jan 4;8(1). Epub 2022 Jan 4.

Instituto Privado de Oftalmología, La Paz, Bolivia.

Background: To describe the epidemiological traits, clinical characteristics, diagnostic procedures, therapeutic interventions and evolution in a large series of patients with diagnosis of Eales' disease.

Methods: A clinical retrospective review of patients with Eales' disease, evaluated and treated between April 2009 and April 2018, with a 1-year minimum follow-up. Thirty patients (59 eyes), were included. Read More