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Eye (Lond) 2022 Jun 28. Epub 2022 Jun 28.

Birmingham and Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

Purpose: To report the contribution to carbon dioxide equivalent mass [COEM] of various types of VR surgery performed across three tertiary referral centres, according to their indication and fluorinated gas used. We secondarily reported on the difference in tamponade choice, and COEM between the different centres.

Materials: Retrospective, continuous, comparative multicentre study of all procedures using fluorinated gases between 01/01/17-31/12/20 at the Manchester Royal Eye Hospital and Birmingham and Midland Eye Centre, and between 01/01/19-31/12/2020 at the University Hospitals Coventry and Warwickshire. Read More

Exp Eye Res 2022 Jun 24:109163. Epub 2022 Jun 24.

Department of Ophthalmology and Visual Sciences, The University of Alabama at Birmingham, Birmingham, AL, United States.

Understanding the molecular composition of ocular tissues and fluids could inform new approaches to prevalent causes of blindness. Subretinal fluid accumulating between the photoreceptor outer segments and retinal pigment epithelium (RPE) is potentially a rich source of proteins and lipids normally cycling among outer retinal cells and choroid. Herein, intact post-translationally modified proteins (proteoforms) were extracted from subretinal fluids of five patients with rhegmatogenous retinal detachment (RRD), analyzed by tandem mass spectrometry, and compared to published data on these same proteins as synthesized by other organs. Read More

J Clin Med 2022 Jun 17;11(12). Epub 2022 Jun 17.

Ophthalmology Clinic, Department of Medicine and Science of Ageing, University Gabriele D'Annunzio Chieti-Pescara, 66100 Chieti, Italy.

Background: In this study we aimed at investigating macular perfusion/anatomical changes in eyes with early onset rhegmatogenous retinal detachment (RRD) after prompt surgery within 24 hours, comparing a bisected macula and not bisected macula RRD.

Methods: In this prospective observational study, 14 eyes of 14 patients who underwent within-24 hours vitreoretinal surgery for early onset RRD were enrolled. Patients were further divided into two subgroups: the not bisected macula group (NBM group) and the bisected macula group (BM group). Read More

J Clin Med 2022 Jun 15;11(12). Epub 2022 Jun 15.

Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo 156-0052, Japan.

We retrospectively compared the stability of intraocular lenses (IOLs) routinely used at our institution by measuring IOL position after phacovitrectomy for rhegmatogenous retinal detachment (RRD). Patients with RRD who underwent phacovitrectomy with gas tamponade received one of three IOLs: 6-mm, single-piece NS-60YG (NIDEK, 15 eyes); 6-mm, single-piece XY1 (HOYA, 11 eyes); or 7-mm, three-piece X-70 (Santen, 11 eyes). Various parameters associated with the anterior chamber, lens, and IOL were measured by swept-source anterior segment optical coherence tomography (CASIA2; Tomey Corp) before and 1 week and 1 month after surgery. Read More

Genes (Basel) 2022 Jun 18;13(6). Epub 2022 Jun 18.

John van Geest Centre for Brain Repair, Vitreoretinal Research Group, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK.

The Stickler syndromes are a group of genetic connective tissue disorders associated with an increased risk of rhegmatogenous retinal detachment, deafness, cleft palate, and premature arthritis. This review article focuses on the molecular genetics of the autosomal dominant forms of the disease. Pathogenic variants in causing Stickler syndrome usually result in haploinsufficiency of the protein, whereas pathogenic variants of type XI collagen more usually exert dominant negative effects. Read More

Ophthalmic Res 2022 Jun 23. Epub 2022 Jun 23.

Multiple lines of evidence support an immunologic response along with inflammation to be implicated in the pathophysiology of primary rhegmatogenous retinal detachment (RRD) and the development of proliferative vitreoretinopathy (PVR). The purpose of this review is to provide an update on the signaling molecules into the vitreous and subretinal fluid (SRF) involved in these processes. A detailed literature search was performed in PubMed database until November 2021. Read More

Ther Adv Ophthalmol 2022 Jan-Dec;14:25158414221105222. Epub 2022 Jun 18.

Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Background: Rhegmatogenous retinal detachment (RRD) with macular involvement is a sight-threatening condition. Silicone oil (SO) is efficacious for retinal tamponade, especially in complex cases. Whether macular detachment per se or the potential tamponading agent may affect macular microcirculation after RRD repair is a matter of research. Read More

Am J Ophthalmol Case Rep 2022 Sep 11;27:101614. Epub 2022 Jun 11.

Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.

Purpose: To describe a case of a chronic retinal detachment complicated by the development of pre and subretinal hemorrhage secondary to a large pseudoangiomatous retinal gliosis (PARG) that interfered with retinal reattachment. After the lesion was regressed following plaque radiotherapy retinal reattachment was successfully completed.

Observations: A 56y. Read More

Clin Ophthalmol 2022 16;16:1971-1984. Epub 2022 Jun 16.

Asociados de Macula, Vitreo y Retina de Costa Rica, Primer Piso Torre Mercedes Paseo Colon, San José, Costa Rica.

Scleral buckling (SB) remains an important technique to master for those interested in treating rhegmatogenous retinal detachment (RRD). Several ways to repair RRD include pneumatic retinopexy (PR), pars plana vitrectomy (PPV), SB or a combination of these. There is a growing worldwide trend that favors PPV as the preferred method for retinal reattachment of primary uncomplicated RRD. Read More

Retina 2022 07;42(7):1262-1267

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Purpose: To compare surgical outcomes of filtered air and sulfur hexafluoride (SF6) as an internal tamponade in patients undergoing primary 25-gauge pars plana vitrectomy for uncomplicated rhegmatogenous retinal detachment with inferior breaks.

Methods: Patients with uncomplicated rhegmatogenous retinal detachment associated with inferior breaks (between 4 and 8 o'clock positions) who were undergoing primary pars plana vitrectomy were enrolled. All eyes underwent pars plana vitrectomy and complete drainage of subretinal fluid, followed by filtered air or 20% SF6 tamponade. Read More

Cureus 2022 May 17;14(5):e25092. Epub 2022 May 17.

Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.

Background Regardless of the advancements in ophthalmology, rhegmatogenous retinal detachment (RRD) remains a substantial issue for physicians. The present study assessed the incidence of RRD among our population. Methodology A cross-sectional study was performed at the Layton Rehmatullah Benevolent Trust (LRBT) between June 2020 and May 2021. Read More

JNMA J Nepal Med Assoc 2022 Jun 1;60(250):555-558. Epub 2022 Jun 1.

Kathmandu University School of Medical Sciences, Dhulikhel Hospital, Dhulikhel, Kavre, Nepal.

Neurofibromatosis type 1 is a genetic disorder that follows an autosomal dominant pattern of inheritance. Ocular involvement is not uncommon, but spontaneous dialysis of the retina in the absence of a history of trauma is a rare clinical entity. Rare cases of retinal involvement such as retinal detachment or dialysis of ora serrata could be linked with the abnormal cell-matrix formation in neurofibromatosis type 1. Read More

Sci Rep 2022 Jun 10;12(1):9630. Epub 2022 Jun 10.

Department of Ophthalmology, Hangil Eye Hospital, #35 Bupyeong-daero, Bupyeong-gu, Incheon, 21388, Republic of Korea.

The study aimed to evaluate the long-term changes in circumpapillary retinal nerve fiber layer (RNFL) thickness after vitrectomy for rhegmatogenous retinal detachment (RRD) repair. A total of 33 eyes of 33 patients were enrolled. By using optical coherence tomography, the circumpapillary RNFL thickness was measured before surgery and 1, 3, 6 months and 1, 2, 3 years after surgery and compared with the preoperative value. Read More

Ophthalmology 2022 Jun 6. Epub 2022 Jun 6.

Department of Ophthalmology University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Objective: Proliferative Vitreoretinopathy (PVR) is the major cause for surgical failure after primary rhegmatogenous retinal detachment (RRD). So far, there is no proven therapy to prevent PVR. Promising results for 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) in high-risk eyes have been reported previously. Read More

Am J Ophthalmol Case Rep 2022 Sep 1;27:101604. Epub 2022 Jun 1.

University of Maryland School of Medicine, Baltimore, MD, USA.

Purpose: To report a case of a 42-year-old male with proliferative diabetic retinopathy (PDR) complicated by tractional retinal detachments (TRD) bilaterally with a rare finding on B-scan ultrasonography.

Observations: On B-scan ultrasound, a total combined rhegmatogenous-TRD was observed, accompanied by extensive retinal macrocysts that appeared nearly confluent for 360°.

Conclusions And Importance: Retinal macrocysts are rare but important clinical entities that help drive management, as their presence typically suggests a chronic retinal detachment. Read More

BMC Ophthalmol 2022 Jun 8;22(1):257. Epub 2022 Jun 8.

Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, 200031, People's Republic of China.

Background: We aimed to explore the changes in the axial length and related factors after vitrectomy for rhegmatogenous retinal detachment (RRD).

Methods: This study retrospectively evaluated patients who underwent vitrectomy with silicone oil (SO) tamponade for RRD and subsequent silicone oil removal at our clinic. Using a Zeiss IOLMaster 700, axial length was measured before vitrectomy for RRD and SO removal. Read More

Int Ophthalmol 2022 Jun 8. Epub 2022 Jun 8.

Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, No 23, Boostan 9 St., Pasdaran Ave, 16666, Tehran, Iran.

Purpose: To evaluate the outcomes and complications of simultaneous silicon oil removal (SOR) and phacoemulsification and intra ocular lens implantation.

Methods: In this retrospective non-comparative case series, the visual, refractive and anatomical outcomes of patients who underwent combined phacoemulsification/silicone oil removal (5700 centistokes) surgery between 2017 and 2019 in a single center were evaluated.

Results: Forty-four eyes of 44 patients (eighteen males) were included. Read More

Acta Ophthalmol 2022 Jun 8. Epub 2022 Jun 8.

Department of Vitreoretinal Surgery, the Rotterdam Eye Hospital, Rotterdam, The Netherlands.

Purpose: We previously hypothesized a causal relationship between vitreoschisis-induced vitreous cortex remnants (VCR) and the development of proliferative vitreoretinopathy (PVR). This study aims to substantiate this association through histopathological analysis of surgical specimens in support of strategies to improve therapeutic outcomes.

Methods: A descriptive, prospective, non-consecutive case series. Read More

Semin Ophthalmol 2022 Jun 6:1-6. Epub 2022 Jun 6.

Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Purpose: To provide an updated, critical summary of the literature on the topic of persistent subretinal fluid (PSF) following successful rhegmatogenous retinal detachment surgery.

Methods: Narrative literature review.

Results: PSF remains an insufficiently studied topic. Read More

Semin Ophthalmol 2022 Jun 6:1-4. Epub 2022 Jun 6.

Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, Pittsburg, PA, USA.

Purpose: To validate Lincoff's rules (LRs) in cases of rhegmatogenous retinal detachment (RRD) in the pediatric age group and to identify factors in cases LR was not followed.

Method: This was a retrospective study where 98 pediatric patients with RRD were identified through surgery records. Forty case sheets with complete record of ocular examination and surgical findings were analyzed. Read More

Ophthalmol Retina 2022 May 31. Epub 2022 May 31.

Westmead and Central Clinical Schools, Specialty of Ophthalmology and Eye Health, The University of Sydney, Sydney, New South Wales, Australia; Department of Ophthalmology, Faculty of Medicine, Health and Human Sciences, Macquarie University Hospital, Sydney, New South Wales, Australia. Electronic address:

Purpose: To determine if a difference exists between cryotherapy and endolaser photocoagulation retinopexy in the rates of anatomical success following primary rhegmatogenous retinal detachment (RRD) repair with pars plana vitrectomy (PPV).

Design: Registry-based, non-randomized, observational cohort study.

Subjects: Eyes with primary RRD in a bi-national retinal surgery registry who underwent repair with PPV and had a minimum of 3-months follow-up. Read More

Indian J Ophthalmol 2022 Jun;70(6):2197-2198

Department of Ophthalmology, Retina Foundation, Near Shahibag Underbridge, Shahibag, Ahmedabad, Gujarat, India.

Spektrum Augenheilkd 2022 May 24:1-8. Epub 2022 May 24.

Birmingham Midlands Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, Dudley Road, 18 7QH Birmingham, UK.

Purpose: To review the sustained effect of COVID-19 on rhegmatogenous retinal detachment (RRD) baseline characteristics and outcomes.

Methods: This was a retrospective consecutive case series at the Birmingham and Midlands Eye Centre including patients undergoing primary RRD repair between 23 March and 31 December 2017-2019 (Group 1) and 2020 (Group 2). The deciles of indices of multiple deprivation (IMD) were determined by postcode to group patients into least deprived (IMD1-5) and most deprived (IMD6-10). Read More

Med Dosim 2022 May 26. Epub 2022 May 26.

Department of Radiation Oncology, Texas Oncology, Brownsville, TX, USA.

The aim of our study is to document our cases of choroidal melanoma treated with low dose rate (LDR) brachytherapy and to correlate the dosimetry and radiobiology with clinical effects and oncologic outcomes. Data from 157 patients treated from 2014 to 2018 with LDR brachytherapy were used for this investigation. Treatments used a collaborative ocular melanoma study eye plaque and Iodine-125 radioactive seeds. Read More

J Clin Med 2022 May 19;11(10). Epub 2022 May 19.

Department of Ophthalmology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.

We examined the vessel density (VD) of the deep capillary plexus (DCP) and choriocapillaris plexus (CCP) by optical coherence tomography (OCT) angiography in eyes with rhegmatogenous retinal detachment, which had similar amounts of detached and nondetached areas in the macula region, and then determined the morphology by OCT until 6 months after surgery. A total of 13 eyes of 13 patients whose average age was 55.8 ± 12. Read More

Br J Ophthalmol 2022 May 26. Epub 2022 May 26.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada

Background/aim: To assess the utility of single-capture ultra-widefield confocal scanning laser ophthalmoscope with integrated swept-source optical coherence tomography (UWF-SS-OCT) in the management of rhegmatogenous retinal detachment (RRD) and associated peripheral pathology.

Methods: 138 eyes of 101 consecutive patients with RRD and/or associated peripheral pathology at a vitreoretinal practice in Toronto, Canada between December 2020 and February 2021 that had UWF-SS-OCT with interpretable scans were included. A 200 degree fundus photograph was used to navigate a built-in 100 kHz UWF-SS-OCT to image pathology with a high-density 23 mm line scan and/or volume scan. Read More

Ophthalmic Genet 2022 May 26:1-8. Epub 2022 May 26.

Moorfields Eye Hospital, London, UK.

Purpose: Bi-allelic mutations in LAMA1 (laminin 1) (OMIM # 150320) cause Poretti-Boltshauser Syndrome (PTBHS), a rare non-progressive cerebellar dysplasia disorder with ophthalmic manifestations including oculomotor apraxia, high myopia, and retinal dystrophy. Only 38 variants, nearly all loss of function have been reported. Here, we describe novel LAMA1 variants and detailed retinal manifestations in two unrelated families. Read More

Am J Ophthalmol 2022 May 21. Epub 2022 May 21.

Department of Ophthalmology & Visual Neurosciences, University of Minnesota Medical School, Minneapolis, MN, USA; VitreoRetinal Surgery, P.L.L.C., Minneapolis, MN, USA. Electronic address:

Purpose: Evaluate factors associated with coronavirus 2019 (COVID-19) vaccine hesitancy and clinical trends in primary rhegmatogenous retinal detachments (RRD) during first year of vaccine availability.

Design: Single-center, clinical cohort study METHODS: : Consecutive patients from December 14, 2020 to December 12, 2021 presenting vaccinated (Prior-), subsequently vaccinated (Later-), or remaining unvaccinated (Never-Vax). Primary outcome was proportion with macula-off (mac-off) RRD. Read More

Curr Eye Res 2022 Jun 6:1-9. Epub 2022 Jun 6.

Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To determine factors associated with loss of good vision (defined as Snellen visual acuity [VA] < 20/40) after surgery among eyes presenting with macula-on primary rhegmatogenous retinal detachment (RRD) with initial VA ≥20/40.

Methods: Multicenter, retrospective, cohort study of eyes undergoing scleral buckle (SB), pars plana vitrectomy (PPV), or combined pars plana vitrectomy/scleral buckle (PPV/SB) for non-complex macula-on RRD with initial VA ≥20/40.

Results: Among 646 eyes with macula-on RRDs with initial VA ≥20/40, 106 (16. Read More

Cureus 2022 Apr 18;14(4):e24234. Epub 2022 Apr 18.

Department of Ophthalmology, The University of Jordan, Amman, JOR.

Describe a case of acquired heterochromia after intraocular surgery. A 63-year-old healthy female patient presented to the eye clinic with rhegmatogenous retinal detachment in her left eye. She underwent uncomplicated pars plana vitrectomy with implantation of posterior chamber intraocular lens. Read More