Search Our Scientific Publications & Authors

Cir Cir 2019 ;87(2):136-140

Servicio de Oftalmología, Hospital Juárez de México. Ciudad de México, México.

Objective: To compare the frequency of anatomic and functional success, between eyes with uncomplicated rhegmatogenous retinal detachment treated with exoplant or vitrectomy.

Method: Non-experimental, retrospective, comparative and longitudinal study in patients with rhegmatogenous retinal detachment, <20/200 visual acuity and macular involvement, treated with exoplant (group 1) or vitrectomy (group 2), and 9 months follow up, without proliferative vitreoretinopathy or other vitreoretinal disease that reduced vision. The frequencies of anatomic success (attached retina) and functional success (visual acuity > 20/200) were compared between groups at the end of follow up (chi squared and odds ratio). Read More

Cir Cir 2019 ;87(2):215-218

Facultad de Medicina, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México.

Background: Pupillary block induced by silicon oil in vitrectomized patients is a common condition usually treated with Nd-YAG laser iridotomy or with surgical removal of silicon oil.

Case Report: A case of silicone oil pupillary block glaucoma successfully treated with a 30 G needle transfixion technique is described. We performed a non-complicated vitrectomy surgery for retinal detachment with proliferative vitreoretinopathy that included lensectomy, inferior peripheral iridectomy, and silicone oil injection. Read More

Ophthalmologica 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Ophthalmology, College of Medicine, Hallym University, Hwaseong, Republic of Korea.

Purpose: To assess treatment efficacy of scleral buckling surgery with wide-field surgical microscope and 27-gauge (G) chandelier illumination for rhegmatogenous retinal detachment (RRD).

Methods: This study is a retrospective chart review of 29 eyes in 29 patients with RRD who underwent scleral buckling surgery with a wide-field surgical microscope and 27-G chandelier illumination fiber inserted into the sclera at the pars plana. Results are expressed as mean ± standard deviation. Read More

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan.

Purpose: To evaluate real-world evidence for young Japanese patients with rhegmatogenous retinal detachment (RRD) by retrospectively examining surgical procedures and clinical outcomes in the Japan Clinical Retina Study group.

Methods: This was a multicentre retrospective study of the medical records of 562 young patients (384 males and 178 females; mean age: 33.0 ± 11. Read More

Exp Eye Res 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, 1 East Jianshe Road, Zhengzhou, 450052, China. Electronic address:

Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment failure. The mechanism of PVR development is complex and still not completely elucidated. There are no proven methods for early prevention or clinical treatment. Read More

Ophthalmology 2019 Jan 31. Epub 2019 Jan 31.

Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Associated Retinal Consultants, Royal Oak, MI.

Purpose: To report the structural and functional outcomes of the autologous neurosensory retinal transplant for closure of refractory large macular holes.

Design: Multicenter retrospective consecutive case series PARTICIPANTS: Forty-one eyes of 41 patients (27 female and 14 male) with a full thickness macular hole refractory to prior vitrectomy with internal limiting membrane peel and tamponade.

Methods: All patients underwent pars-plana vitrectomy, autologous neurosensory retinal transplant with either gas, silicone oil tamponade, or short-term Perfluoro-n-octane heavy-liquid tamponade. Read More

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Instituto de la Visión-Hospital La Carlota, Montemorelos, Nuevo León, México

Purpose: To compare the effectiveness of intravitreal ziv-aflibercept (IVZ) to intravitreal bevacizumab (IVB) administered preoperatively to patients undergoing pars plana vitrectomy (PPV) for severe manifestations of proliferative diabetic retinopathy (PDR).

Design: Randomised clinical trial (RCT).

Methods: Two hundred and six patients with PDR-related complications requiring PPV were randomised into one of two treatment groups: Group A received IVZ (1. Read More

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Vitreo-retinal Unit, Manchester Royal Eye Hospital, Manchester, UK.

We report the case of a 32-year-old Afrocaribbean man with known stage 3 proliferative sickle-cell retinopathy who presented with a mixed picture of tractional and rhegmatogenous macula off detachment. He underwent left primary 25 g vitrectomy with silicone oil, delamination and endolaser photocoagulation under a general anaesthetic. He, however, presented 48 hours postoperatively with gross anterior segment ischaemia. Read More

Retina 2019 Jan 24. Epub 2019 Jan 24.

Department of Ophthalmology, Southwest Hospital, Southwest Eye Hospital, Army Medical University, Chongqing, China.

Purpose: To compare the impact of surgical timing on anatomical and functional outcomes of vitrectomy for open-globe injury.

Methods: Fifty-three patients were entered into this prospective open-label study, with 26 patients randomized into early surgery group (vitrectomy conducted within 4 days) and 27 into delayed surgery group (vitrectomy performed between 10-14 days after injury). Six-month data were available for 46 patients and 7 were lost to follow-up. Read More

Curr Res Transl Med 2019 Jan 23. Epub 2019 Jan 23.

Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, H1T1C8, Quebec, Canada.

Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) present two examples of proliferative retinopathy, characterized by the same stages of progression; ischemia of the retinal vessels, leads to hypoxia and to correct the problem there is the setting up of uncontrolled angiogenesis, which subsequently causes blindness or even detachment of the retina. The difference is the following; that DR initiated by the metabolic complications that are due to hyperglycemia, and ROP is induced by overexposure of the neonatal retina to oxygen. In this review, we will demonstrate the physiopathological mechanism of the two forms of proliferative retinopathy DR and ROP, in particular the role of the CD40/CD40L axis and IL-1 on vascular complications and onset of inflammation of the retina, the implications of their effects on the onset of pathogenic angiogenesis, thus understanding the link between platelets and retinal ischemia. Read More

Am J Ophthalmol 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia College of Physicians and Surgeons, New York, NY, USA; Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore.

Purpose: To determine factors predictive of anatomic, visual and financial outcomes after traditional and nontraditional primary pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RD).

Design: Retrospective interventional case series and cost comparison Methods: PARTICIPANTS: 178 eyes (156 patients) with PR-repaired primary RD by a single surgeon at a clinical practice from 1/2001-12/2013 and followed for ≥1 year. The cohort had 2 sub-groups: traditional (TPR) and nontraditional (NTPR) PR. Read More

Cell Biosci 2019 21;9:12. Epub 2019 Jan 21.

Department of Ophthalmology, Huaihe Hospital, Henan University, No.8 of Baobei Road, Kaifeng, 475000 People's Republic of China.

Background: Proliferative vitreoretinopathy (PVR) is a severe blinding complication of retinal detachment surgery. Increasing evidence demonstrate that PVR is associated with oxidative stress. Scutellarin is a natural flavone compound that has been reported to have anti-oxidative activity. Read More

J Ocul Pharmacol Ther 2019 Jan 22. Epub 2019 Jan 22.

Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, China.

Purpose: We compared the efficacies of intravitreal ranibizumab (IVR) and intravitreal conbercept (IVC) as the adjuvant pretreatments for vitrectomy with silicone oil infusion for tractional retinal detachment (TRD) secondary to proliferative diabetic retinopathy.

Methods: This retrospective study comprised 74 patients (79 eyes) who underwent vitrectomy with silicone oil tamponade for diabetic TRD. They received IVC (37 eyes) or IVR (42 eyes) at standard doses 3-5 days preoperatively and were followed up for ∼6 months. Read More

Invest Ophthalmol Vis Sci 2019 Jan;60(1):282-293

Byers Eye Institute, Omics Laboratory, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States.

Purpose: To gain insight into the pathophysiology of vitreoretinal degeneration, the clinical course of three family members with Versican Vitreoretinopathy (VVR) is described, and a canonical splice site mutation in the gene encoding for versican (VCAN) protein was biochemically analyzed.

Methods: A retrospective chart review, human eye histopathology, Sanger DNA sequencing, protein structural modeling, and in vitro proteolysis assays were performed.

Results: The proband (II:1), mother (I:2), and younger sibling (II:2) suffered retinal degeneration with foveal sparing and retinal detachments with proliferative vitreoretinopathy, features that were confirmed on histopathologic analysis. Read More

BMC Ophthalmol 2019 Jan 14;19(1):17. Epub 2019 Jan 14.

Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.

Background: To identify the clinical characteristics, prognostic factors and visual outcomes in posterior segment IOFBs patients managed by PPV in a tertiary hospital.

Methods: A retrospective chart review was performed for 56 patients, who had PPV for IOFBs removal between November 2013 and November 2015. The mechanisms of injury, the nature of the IOFBs, the BCVA before and after the surgery, the penetrating site and the complications of the surgery were all collected. Read More

Retin Cases Brief Rep 2019 Jan 11. Epub 2019 Jan 11.

Aurora St. Luke's Medical Center, Milwaukee, Wisconsin.

Purpose: To present a case of retinal detachment caused by a Nerf-gun shot in a pediatric patient.

Methods: Single case report.

Results: A 16-year-old white man presented with a nasal visual field deficit and floaters in his left eye for 1 month after being shot with a foam-ball Nerf gun by a friend. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 Jan;50(1):42-49

Background And Objective: To compare between trimanual and unimanual vitrectomy in complicated proliferative diabetic retinopathy (PDR).

Patients And Methods: A prospective, non-randomized, comparative study including patients with tractional retinal detachment (TRD), vitreous hemorrhage with TRD, and combined TRD with rhegmatogenous retinal detachment. The patients were allocated into two groups: the unimanual group with three-port vitrectomy and the trimanual group with added fourth sclerotomy, through which the endoillumination probe was guided by the assistant. Read More

Taiwan J Ophthalmol 2018 Oct-Dec;8(4):249-252

Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

We report a case with multiple recurrences of retinal detachment (RD) with severe proliferative vitreoretinopathy in a 12-year-old child who underwent vitrectomy using a heavy liquid perfluoro-n-octane (PFO) as a short-term postoperative tamponade. He had an encircling band and three vitrectomies with gas, followed by silicone oil tamponade for retinal redetachment prior to the use of PFO as a short-term tamponade. Short-term PFO tamponade was used in which inferior retinal reattachment was considered to be difficult with conventional gas or silicone oil tamponade, especially in regard to proper postoperative posturing. Read More

Taiwan J Ophthalmol 2018 Oct-Dec;8(4):189-195

Retina Consultants Ltd., Des Plaines, Illinois, USA.

Stickler Syndrome (SS) is a significant cause of retinal blindness in children. The immediate cause of blindness is retina detachment from giant retinal tear (GRT). It is frequently diagnosed late and the giant retinal tear (GRT) may be complicated by high-grade proliferative vitreoretinopathy (PVR). Read More

JAMA Ophthalmol 2019 Jan 10. Epub 2019 Jan 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Importance: Diabetic retinopathy is the leading cause of blindness in working-age adults. Studies have suggested that statins may reduce the risk of developing diabetic retinopathy.

Objective: To investigate the association between statin therapy and the development of diabetic retinopathy in patients with diabetes and dyslipidemia. Read More

Retin Cases Brief Rep 2019 Winter;13(1):21-24

Vitreo Retina Services, Dr RP Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

Purpose: 1) To evaluate factors governing flow of subretinal fluid and validate Lincoff rules (LRs) in cases of rhegmatogenous retinal detachment. 2) To identify cases of rhegmatogenous retinal detachment where LRs are not followed.

Method: This was a retrospective study where 253 patients of rhegmatogenous retinal detachment were identified through surgery records. Read More

Acta Ophthalmol 2018 Dec 18. Epub 2018 Dec 18.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Purpose: To compare the cytokine profiles of phakic (p) and pseudophakic (ps) eyes with primary rhegmatogenous retinal detachment (RD) to eyes with macular holes (MH) and to identify differences in the specific cytokine profiles.

Methods: Aqueous humour (AH) and vitreous fluid (VF) were obtained from patients with primary RD without proliferative vitreoretinopathy undergoing vitrectomy. AH and VF of patients with macular holes (MH) served as controls. Read More

J Ophthalmol 2018 6;2018:3470731. Epub 2018 Nov 6.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: To evaluate logical surgical approaches to closing macular holes in eyes with proliferative diabetic retinopathy with retinal detachment.

Methods: Retrospective, interventional case series.

Results: 10 eyes in 10 patients were included in this study. Read More

Acta Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: Unremoved vitreoschisis-induced vitreous cortex remnants (VCR) are associated with macular pathology. When present on the retinal periphery, they may play a role in proliferative vitreoretinopathy and retinal detachment after vitrectomy. Existing instruments for their removal involve substantial risk of iatrogenic retinal damage. Read More

Clin Ophthalmol 2018 14;12:2323-2329. Epub 2018 Nov 14.

Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan,

Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.

Subjects And Methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Read More

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):918-922

Tianjin Medical University Eye Hospital, College of Optometry and Ophthalmology, Tianjin Medical University Eye Institute, Tianjin 300384, China.

To report the clinical outcomes and safety profile of 27G(+) transconjunctival sutureless vitrectomy (TSV) in eyes with posterior segment disease. Prospective, interventional case series. Eyes undergoing 27G(+) TSV for a vitreoretinal surgery indication were included from Dec 2015 to Mar 2016. Read More

Ann Clin Biochem 2018 Dec 4:4563218820359. Epub 2018 Dec 4.

Qilu Hospital of Shandong University (Qingdao).

Objective: Adropin, a newly identified regulatory protein encoded by Enho gene, is correlated with insulin sensitivity and diabetes. The aim of this study is to determine whether serum and vitreous adropin concentrations are correlated with the presence of diabetic retinopathy (DR).

Methods: A population of 165 patients with type 2 diabetes mellitus (T2DM) [52 without DR, 69 with non-proliferative diabetic retinopathy (NPDR), and 44 patients with proliferative diabetic retinopathy (PDR)] was enrolled in this study. Read More

Indian J Ophthalmol 2018 Dec;66(12):1763-1771

Department of Retina and Vitreous, Retina Foundation, Ahmedabad, Gujarat, India.

Rhegmatogenous retinal detachment (RRD) repair is one of the most common vitreoretinal surgeries a surgeon performs. In an ideal scenario, RRD can be repaired with a single surgical intervention; however, despite excellent skill, flawless technique, and the introduction of high-end technology, up to 10% of cases require additional interventions to ultimately repair recurrent detachments. It is thus important to study the outcomes of multiple interventions to understand whether performing repeat vitrectomy on patients with a history of failed surgeries is worthwhile. Read More

Indian J Ophthalmol 2018 Dec;66(12):1751-1762

Department of Ophthalmology, Kittner Eye Center, University of North Carolina, Chapel Hill, NC, USA.

Twenty-five percent of diabetes-related vision loss stems from complications of proliferative diabetic retinopathy (PDR). Panretinal photocoagulation has been the preferred treatment of high-risk PDR for decades and more recently intravitreal injections of drugs that inhibit the actions of vascular endothelial growth factor have become popular. But despite these treatments PDR may progress uncontrollably to advanced pathologies such as traction retinal detachments (TRDs), combined traction/rhegmatogenous retinal detachments (TRD/RRDs), vitreous hemorrhages, rubeosis iridis, and traction maculopathies, which produce mild-to-severe loss of vision. Read More

Int J Ophthalmol 2018 18;11(11):1779-1783. Epub 2018 Nov 18.

Department of Ophthalmology, University of the West Indies, St. Augustine Trinidad and Tobago.

Aim: To report the results of rhegmatogenous retinal detachment (RRD) repair after pars plana vitrectomy (PPV) without operative use of heavy liquid, and utilizing air tamponade in selected cases.

Methods: RRD patients without severity of proliferative vitreoretinopathy C or more underwent PPV without operative use of heavy liquid, and utilizing air tamponade were consecutively enrolled. Alternative postoperative facedown position or lateral position was required for 3-5d. Read More

Semin Ophthalmol 2018 Nov 14:1-10. Epub 2018 Nov 14.

a Department of Ophthalmology , Keimyung University School of Medicine, Dongsan Medical Center , Daegu , Republic of Korea.

Purpose: To observe course of subretinal proliferation (SRP) after scleral buckling (SB) for the rhegmatogenous retinal detachment.

Methods: Fundus photographs and serial optical coherence tomographies (OCTs) were retrospectively analyzed in 10 cases from 9 patients.

Results: Preoperative SRP locations were beneath the retina in six cases, intraretinal in one, and between the retina and retinal pigment epithelium (RPE) in one. Read More

Jpn J Ophthalmol 2019 Jan 8;63(1):109-118. Epub 2018 Nov 8.

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Purpose: To describe the epidemiology and clinical outcomes of open globe injuries (OGIs) in Japan over 10 years, and examine preoperative factors influencing the visual prognosis after surgery.

Study Design: Retrospective, observational, multicenter case-series study.

Methods: Patients' data were entered into a computerized database for review and statistical analyses. Read More

Ophthalmic Genet 2018 Dec 8;39(6):754-758. Epub 2018 Nov 8.

a Retinal Consultants , Des Plaines , IL , USA.

Background: Loeys-Dietz syndrome (LDS) is a connective tissue disorder that has phenotypic overlap with Marfan syndrome. In LDS, the aortic root dissections can be more aggressive and occur at a younger age than Marfan syndrome.

Materials And Methods: Review of two cases. Read More

Br J Ophthalmol 2018 Oct 31. Epub 2018 Oct 31.

The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania, USA.

Purpose: To examine the effect of low-dose, oral isotretinoin in lowering the risk of proliferative vitreoretinopathy (PVR) following rhegmatogenous retinal detachment (RRD) repair.

Methods: Prospective, open label, dual-cohort study with pathology-matched historical controls. The prospective experimental arms included two cohorts, composed of 51 eyes with recurrent PVR-related RRD and 58 eyes with primary RRD associated with high-risk features for developing PVR. Read More

Diabetes Ther 2018 Dec 30;9(6):2393-2398. Epub 2018 Oct 30.

Department of Ophthalmology, 3201 Hospital, Xi'an Jiaotong University Health Science Center, Hanzhong, Shaanxi, China.

Introduction: Conbercept is a new anti-vascular endothelial growth factor drug approved for the treatment of age-related macular degeneration by the China Food and Drug Administration (CFDA) in 2013. In this study, we for the first time evaluated the concentrations of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) after patients with proliferative diabetic retinopathy were treated with intravitreal conbercept (IVC) injection.

Methods: Sixteen patients with proliferative diabetic retinopathy were randomly divided into two equal groups (A and B). Read More

J Coll Physicians Surg Pak 2018 Nov;28(11):848-852

Department of Ophthalmology, LRBT Free Base Eye Hospital, Karachi, Pakistan.

Objective: To evaluate the anatomical and functional outcomes of retinectomy in the management of primary rhegmatogenous retinal detachments with inferior retinal breaks and advanced proliferative vitreoretinopathy (PVR C).

Study Design: Quasi-experimental study.

Place And Duration Of Study: LRBT, Free Base Eye Hospital, Karachi, from July 2015 to June 2017. Read More

Curr Eye Res 2018 Oct 26:1-5. Epub 2018 Oct 26.

c Department of Ophthalmology , Qingdao Municipal Hospital , Qingdao , China.

Purpose: This study was undertaken to assess the associations between the anatomic outcomes of patients who underwent vitrectomy for rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) and their preoperative variables.

Methods: A total of 175 patients with RRDCD who underwent vitrectomy in one eye were included in the analysis. The primary outcome measured was the retinal status after primary vitrectomy and at the end of follow-up. Read More

Invest Ophthalmol Vis Sci 2018 Oct;59(12):4929-4936

Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.

Purpose: To determine if vitreous levels of the pro-fibrotic cytokine transforming growth factor beta2 (TGF-β2) and its opposing regulator decorin predict subsequent proliferative vitreoretinopathy (PVR) development in patients with rhegmatogenous retinal detachment (RRD).

Methods: We examined the effect of TGF-β2 and decorin on epithelial-mesenchymal transition (EMT) and collagen expression in vitro using ARPE-19 cells, and we analyzed extracellular matrix marker expression in PVR membrane and internal limiting membrane patient samples. We performed a prospective noninterventional cohort study, recruiting 125 patients undergoing vitrectomy for RRD and macular hole surgery, measured vitreous levels of TGF-β2 and decorin by ELISA, and followed them up for 6 months. Read More

Curr Eye Res 2018 Oct 12:1-7. Epub 2018 Oct 12.

a Department of Ophthalmology , Gachon University Gil Hospital , Incheon , Korea.

Purpose: To demonstrate the advantages and efficacy of an air-perfused membrane dissection to control intraoperative bleeding in 23-gauge sutureless vitrectomy for proliferative diabetic retinopathy with severe fibrovascular membranes. Meterials and Methods: A prospective, consecutive, interventional case series of 15 eyes that underwent air-perfused diabetic vitrectomy (air vitrectomy group) for removal of the membranes was compared with a retrospective, membrane-matched case series of 10 eyes that underwent conventional diabetic vitrectomy (conventional vitrectomy group). The main outcome measures were real vitrectomy time, intraoperative and postoperative complications, and anatomic and functional successes at the final examination. Read More

Arch Soc Esp Oftalmol 2019 Jan 9;94(1):12-17. Epub 2018 Oct 9.

Centro de Investigación Biomédica, Fundación «Hospital Nuestra Señora de la Luz» IAP, Ciudad de México, México.

Objective: To correlate the vitreous concentration of transforming growth factor β-1 (TGF β-1) with the degree of clinical severity of proliferative vitreoretinopathy (PVR).

Design: A prospective, observational, cross-sectional study carried out on cases and controls.

Participants: The study included 40 patients with a diagnosis of PVR secondary to rhegmatogenous retinal detachment. Read More

Retina 2018 Oct 8. Epub 2018 Oct 8.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: To compare the efficiency of releasable scleral buckling (RSB) and pars plana vitrectomy (PPV) in the treatment of phakic patients with primary rhegmatogenous retinal detachment.

Methods: The current study was a prospective randomized clinical trial. One hundred and ten eyes from 110 patients with primary rhegmatogenous retinal detachment and proliferative vitreoretinopathy of Grade B or less were included in this study. Read More

Acta Ophthalmol 2018 Oct 3. Epub 2018 Oct 3.

Istanbul Retina Institute, Istanbul, Turkey.

Purpose: To evaluate the outcomes of pars plana vitrectomy with silicone oil tamponade in the management of retinal detachment associated with giant retinal tears.

Methods: We reviewed 45 eyes of 42 patients with primary retinal detachment associated with giant retinal tears over 10 years at a tertiary referral centre. Patients underwent 23-gauge vitrectomy without adjuvant scleral buckling by a single surgeon and had follow-up at least 6 months after silicone oil removal. Read More

Int Ophthalmol 2018 Oct 4. Epub 2018 Oct 4.

Department of Ophthalmology, Nihon University Hospital, 1-6 Surugadai, Kanda, Chiyodaku, Tokyo, 101-8309, Japan.

Purpose: To compare postoperative outcomes of 27-gauge (G) and 25-G vitrectomy conducted as day surgery for proliferative diabetic retinopathy (PDR).

Methods: One hundred eighty-five consecutive PDR patients (185 eyes) who underwent primary vitrectomy (27-G in 64 eyes, 25-G in 121 eyes) were analyzed.

Results: The 27-G and 25-G groups did not differ significantly in preoperative Early Treatment Diabetic Retinopathy Study (ETDRS) score, age, or preoperative intraocular pressure. Read More

Am J Ophthalmol 2018 Dec 28;196:212-213. Epub 2018 Sep 28.

St. Louis, Missouri, USA.

Int J Ophthalmol 2018 18;11(9):1550-1554. Epub 2018 Sep 18.

Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, Ophthalmology College of Tianjin Medical University, Tianjin 300384, China.

Diabetic retinopathy (DR) is one of the most important types of diabetic microangiopathy, which is a specific change of fundus lesions and is one of the most serious complications of diabetes. When DR develops to proliferative DR, the main factors of decreasing vision, and even blindness, include retinal detachment and vitreous hemorrhage caused by contraction of blood vessels by fiber membrane. Recent studies reported that the formation of fiber vascular membrane is closely related to retinal fibrosis. Read More

Am J Ophthalmol 2018 Nov 3;195:244. Epub 2018 Sep 3.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Ophthalmologe 2018 Dec;115(12):1079-1083

MVZ Augenärztliches Diagnostik- und Therapiezentrum Mönchengladbach/Erkelenz GmbH, Erkelenz, Deutschland.

Proliferative vitreoretinopathy (PVR) is a complication of rhegmatogenous retinal detachment and trauma, which occurs in approximately 10% following vitreoretinal surgery. The visual prognosis for established PVR is poor and so far there is no established conservative treatment for PVR. In the currently recruiting PRIVENT trial the aim is to find a prophylactic treatment possibility for PVR. Read More

Retina 2018 Aug 24. Epub 2018 Aug 24.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado.

Purpose: To evaluate levels of complement factors in human vitreous of eyes with retinal detachments (RDs) and proliferative diabetic retinopathy (PDR) eyes.

Methods: Human vitreous samples were collected from eyes undergoing routine vitrectomy at the University of Colorado Health Eye Center (Aurora, CO). Complement factor D, component C5/C5a, and component C9 levels were measured using enzyme-linked immunosorbent assay and multiplex assays. Read More

Clin Ophthalmol 2018 15;12:1449-1457. Epub 2018 Aug 15.

Department of Public Health, University of Helsinki, Helsinki, Finland.

Background: Pars plana vitrectomy (PPV) combined with phacoemulsification and primary intraocular lens implantation can be performed for the repair of primary rhegmatogenous retinal detachment (RRD; PHACOVIT group). The safety and efficacy of this combined ophthalmic procedure on RRD surgery outcomes remain unclear compared with more conventional PPV technique alone (VITRET group). We explored the need for reoperation after primary surgical procedure in these two groups. Read More

Exp Eye Res 2018 Dec 23;177:191-196. Epub 2018 Aug 23.

RS Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO Block, Vision Research Foundation, Sankara Nethralaya, Chennai, India; Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry, India. Electronic address:

Diabetic retinopathy (DR) is one of the major causes of blindness resulting from prolonged hyperglycemia which leads to breakdown of blood retinal barrier and excessive neovascularization. In our previous study, we demonstrated the presence of germline-specific PIWI-like proteins in human retina and retinal pigment epithelium (RPE) and a discrete function of HIWI2 (PIWIL4) in the assembly of tight junction through Akt/GSK3α/β. Recently, PIWI/piRNA has been suggested to be involved in the development of diabetes. Read More