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Int J Retina Vitreous 2020 29;6:26. Epub 2020 Jun 29.

Department of Ophthalmology, Centro Hospitalar Universitário de Lisboa Norte, EPE-Hospital de Santa Maria, Avenida Professor Egas Moniz, 1649-035 Lisbon, Portugal.

Background: Diabetic retinopathy (DR) is a leading cause of blindness due to diabetic macular edema (DME) or complications of proliferative diabetic retinopathy (PDR). Optical coherence tomography (OCT) is a noninvasive imaging technique well established for DME but less used to assess neovascularization in PDR. Developments in OCT imaging and the introduction of OCT angiography (OCTA) have shown significant potential in PDR. Read More

Clin Ophthalmol 2020 10;14:1559-1563. Epub 2020 Jun 10.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Objective: To report visual acuity in patients undergoing pars plana vitrectomy (PPV) reoperations for complications of proliferative diabetic retinopathy (PDR).

Design: Retrospective case series.

Subjects: Diabetic patients undergoing reoperation with PPV between 2015 and 2018 at a university referral center. Read More

Clin Ophthalmol 2020 9;14:1547-1552. Epub 2020 Jun 9.

Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.

Purpose: This study aimed to investigate the concentrations of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) in vitreous and serum samples, analyze the ratio, and compare among proliferative diabetic retinopathy (PDR) subgroups.

Patients And Methods: This study included 17 eyes of patients with PDR, identified as the PDR group which was divided into three subgroups (vitreous hemorrhage [VH], VH with fibrotic tissues, and tractional retinal detachment), and five control eyes (nucleus and intraocular lens drop). Vitreous and serum samples were obtained on the same day. Read More

Indian J Ophthalmol 2020 Jul;68(7):1432-1435

Department of Vitreo-Retinal Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

Purpose: To evaluate the incidence, risk factor(s), and surgical outcomes of rhegmatogenous retinal detachment (RRD) in patients undergoing pars plana vitrectomy (PPV) with sutureless scleral-fixated intraocular lens implantation (SFIOL).

Methods: Records of patients (1311 eyes, 1234 patients) who underwent PPV and sutureless SFIOL from 2017 to 2018 were retrospectively analyzed.

Results: The indications SFIOL were subluxated lens (33. Read More

Clin Ophthalmol 2020 22;14:1413-1416. Epub 2020 May 22.

Eye Clinic, Cantonal Hospital Sankt Gallen, Sankt Gallen, Switzerland.

Purpose: To evaluate the effect of extrascleral cryocoagulation for the treatment of proliferative vitreoretinopathy (PVR) during retinal detachment repair.

Methods: Patients with a rhegmatogenous retinal detachment associated with peripheral PVR Grade C star-folds were included in this study and analysed retrospectively. In all patients, PVR star-folds were treated by extrascleral cryocoagulation. Read More

Ophthalmol Retina 2020 Jun 13. Epub 2020 Jun 13.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Objective: The hallmark of proliferative diabetic retinopathy (PDR) is retinal neovascularization (NV). Tortuous intraretinal vascular segments known as intraretinal microvascular abnormalities (IRMAs) are a known risk factor for NV, but whether IRMA represents a biomarker or a vascular precursor lesion to NV has not been demonstrated. The purpose of this study was to document that IRMA may directly evolve into NV. Read More

PLoS One 2020 15;15(6):e0234525. Epub 2020 Jun 15.

Department of Ophthalmology, Semmelweis University, Budapest, Hungary.

Our purpose was to evaluate the concentrations of vitreous cytokines in patients with rhegmatogenous retinal detachment (RRD). We hypothesized that patients with macula on RRD have lower levels of cytokines compared to patients with macula off RRD and proliferative vitreoretinopathy (PVR). Vitreous fluids were collected during 23G pars plana vitrectomy from 58 eyes of 58 patients. Read More

J Clin Med 2020 Jun 2;9(6). Epub 2020 Jun 2.

Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of the Critical Area, University of Pisa, 56126 Pisa, Italy.

Background: Optical coherence tomography (OCT) has recently been introduced in the operating theatre. The aim of this review is to present the actual role of microscope-integrated optical coherence tomography (MI-OCT) in ophthalmology.

Method: A total of 314 studies were identified, following a literature search adhering to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Read More

Exp Eye Res 2020 May 29;197:108080. Epub 2020 May 29.

Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA. Electronic address:

Proliferative vitreoretinopathy (PVR) is a complication of rhegmatogenous retinal detachment and ocular trauma. The disease is characterized by development of membranes that may apply traction to the retina and cause redetachment. Membrane contractions are attributed to myofibroblasts arising from retinal pigment epithelial cells, glia and fibroblasts. Read More

Indian J Ophthalmol 2020 Jun;68(6):1188-1191

Disha Eye Hospitals, Kolkata, West Bengal, India.

We describe the successful use of the B-HEX pupil expansion device in four cases of combined phacovitrectomy with significant cataract, non-dilating pupil, and surgical vitreoretinal pathologies including vitreous hemorrhage, inferior retinal detachment (RD) with proliferative vitreoretinopathy in an oil filled eye, recurrent rhegmatogenous RD, and macular hole with RD localized to the posterior pole in an eye with uveitic sequelae. The B-HEX remained well engaged and maintained excellent mydriasis throughout the surgery despite wide fluctuations in intraocular pressure and anterior chamber fluidics. This is the first series describing use of B-HEX for combined phacovitrectomy due to myriad causes. Read More

J Clin Med 2020 May 21;9(5). Epub 2020 May 21.

Department of Ophthalmology, University of Catania, 95100 Catania, Italy.

The treatment for rhegmatogenous retinal detachment (RRD) is surgery, including pars plana vitrectomy (PPV) and scleral buckling (SB). Despite surgical advances, degeneration of the photoreceptors and post-operative complications, such as proliferative vitreoretinopathy (PVR), often occurs as the result of inflammation, preventing complete visual recovery or causing RRD recurrence. There is increasing evidence that in the presence of RRD, the activation of inflammatory processes occurs and the surgery itself induces an inflammatory response. Read More

Int Ophthalmol 2020 May 21. Epub 2020 May 21.

College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.

Purpose: To investigate the relationship between αB-crystallin levels in the vitreous of patients with rhegmatogenous retinal detachment (RRD) and correlate these levels with the presence of proliferative vitreoretinopathy (PVR) and to the extent of RRD.

Methods: Prospective, cross-sectional study. Vitreous samples were collected from twenty-six patients with RRD at the surgical repair. Read More

Ophthalmology 2020 May 8. Epub 2020 May 8.

The Retina Service of Wills Eye Hospital, Mid-Atlantic Retina, Philadelphia, Pennsylvania.

Purpose: This study evaluates outcomes of comparable pseudophakic rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV) or PPV with scleral buckle (PPV-SB).

Design: Multicenter, retrospective, interventional cohort study.

Participants: Data were gathered from patients from multiple retina practices in the United States with RRD in 2015. Read More

Graefes Arch Clin Exp Ophthalmol 2020 May 19. Epub 2020 May 19.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background: To determine the preoperative factors associated with selecting scleral buckling (SB) or pars plana vitrectomy (PPV) to treat rhegmatogenous retinal detachments (RRDs) in the era of microincision vitrectomy surgery.

Methods: A nationwide, multicenter, observational study in the Japan Retinal Detachment Registry was done. From February 2016 to March 2017, 3446 cases were registered, and 3219 among them were analyzed. Read More

Invest Ophthalmol Vis Sci 2020 May;61(5):22

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Purpose: Glial fibrillary acid protein (GFAP) and vimentin are type III intermediate filament proteins, ubiquitously expressed in retinal glial cells. Under retinal stress, both GFAP and vimentin are well-known sensitive markers for retinal gliosis. However, little is known about whether these proteins are released into the vitreous body in response to retinal gliosis or are related to the severity of retinal gliosis seen in proliferative vitreoretinopathy (PVR). Read More

Int J Retina Vitreous 2020 7;6. Epub 2020 May 7.

1Faculty of Medicine, Minia University, Minia, Egypt.

Background: Epiretinal membranes (ERMs) have been reported after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). Peeling of the internal limiting membrane (ILM) can prevent post-PPV ERM formation but has a potential negative impact on macular structure and function.

Purpose: To investigate the anatomical and functional outcomes of ILM peeling during PPV for primary RRD. Read More

Cochrane Database Syst Rev 2020 05 13;5:CD006126. Epub 2020 May 13.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Background: Retinal detachment (RD) with proliferative vitreoretinopathy (PVR) often requires surgery to restore normal anatomy and to stabilize or improve vision. PVR usually occurs in association with recurrent RD (that is, after initial retinal re-attachment surgery), but occasionally may be associated with primary RD. Either way, for both circumstances a tamponade agent (gas or silicone oil) is needed during surgery to reduce the rate of postoperative recurrent RD. Read More

Ophthalmol Ther 2020 May 12. Epub 2020 May 12.

Ophthalmology Department, Centro Hospitalar São João, Oporto, Portugal.

Introduction: Unexplained visual loss after removal of silicone oil from the eye has been described. The purpose of this study is to determine the incidence of unexplained loss of visual acuity after SO removal and to provide possible explanations for this phenomenon.

Methods: This retrospective study included patients that underwent vitreoretinal surgery, at Centro Hospitalar São João, between January of 2012 and October of 2018. Read More

Eye (Lond) 2020 May 12. Epub 2020 May 12.

Ophthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy.

Background/objectives: To compare the efficacy of intraoperative localized and 360° laser retinopexy in cases of rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy and air tamponade.

Subjects/methods: In this interventional, prospective, randomized, comparative study, 93 consecutive cases of RRD were enroled. After randomization 48 eyes received circumferential, while 45 underwent localized intraoperative laser retinopexy. Read More

Vestn Oftalmol 2020 ;136(2):143-151

N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

Retinopathy of prematurity (ROP) is a severe vascular proliferative disease. The appearance of signs of intrauterine infection in the setting of ROP may aggravate the severity of the disease course and lead to development of complications. Two children with residual ROP effects were observe to have delayed manifestations of intrauterine infection. Read More

BMC Ophthalmol 2020 Apr 29;20(1):171. Epub 2020 Apr 29.

Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka, 569-8686, Japan.

Background: Here we report two patients who developed an atypical macular hole (MH) during the treatment course for diabetic macular edema (DME).

Case Presentations: Patient 1 was a 73-year-old male. Optical coherence tomography (OCT) revealed perifoveal retinoschisis (RS) in addition to cystoid macular edema and serous retinal detachment (SRD) in his left eye, and that an MH had developed during the clinical course. Read More

Ophthalmic Surg Lasers Imaging Retina 2020 04;51(4):249-251

Globe perforation following retrobulbar or peribulbar anesthetic injection is a rare but dreaded complication that often results in suboptimal visual outcomes. This video describes a 72-year-old woman who sustained a globe perforation during retrobulbar block in the setting of cataract extraction and later developed a retinal detachment. The retina was repaired with pars plana vitrectomy and silicone oil, resulting in a favorable visual outcome. Read More

Indian J Ophthalmol 2020 May;68(5):812-817

Department of Retina, Amrita University, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Kochi, Kerala, India.

Purpose: To study the incidence and risk factors of raised intraocular pressures (IOPs) in the follow-up of transconjunctival sutureless vitrectomy (TSV).

Methods: A retrospective observational study was performed on 635 patients who underwent TSV under a single surgeon. The IOPs were recorded using a calibrated non-contact tonometer at seven postoperative visits, viz. Read More

Ophthalmology 2020 Mar 9. Epub 2020 Mar 9.

Mid-Atlantic Retina, Philadelphia, Pennsylvania.

Purpose: Anatomically similar rhegmatogenous retinal detachments (RRDs) can be treated with scleral buckle (SB), pars plana vitrectomy (PPV), or SB combined with PPV (PPV/SB). This study compares moderately complex phakic primary RRD treated with SB, PPV, or PPV/SB to review anatomic and visual outcomes.

Design: Multicenter, retrospective, interventional cohort study. Read More

Case Rep Ophthalmol 2020 Jan-Apr;11(1):127-136. Epub 2020 Mar 19.

Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube City, Japan.

We evaluated the visual outcome of combined penetrating keratoplasty (PKP) and 25G pars plana vitrectomy (PPV) performed without a temporary keratoprosthesis or endoscopy in a patient with vitreoretinal disease complicated by severe corneal opacity. The patient was a 68-year-old woman who had severe corneal opacity and silicone oil in her left eye after several previous intraocular surgeries for rhegmatogenous retinal detachment and proliferative vitreoretinopathy. We successfully performed a combined surgery of conventional PKP followed by 25G PPV without the use of a keratoprosthesis. Read More

Ophthalmol Retina 2020 Feb 28. Epub 2020 Feb 28.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

Purpose: To evaluate the visual outcomes and complications associated with noninfectious uveitis in patients presenting with a rhegmatogenous retinal detachment (RRD).

Design: Retrospective cohort study.

Participants: A total of 554 eyes of 523 patients presenting for RRD repair at the Department of Ophthalmology, University of Colorado School of Medicine, between July 2011 and September 2016. Read More

Zhonghua Yan Ke Za Zhi 2020 Apr;56(4):272-278

Department of Ophthalmology, Peking University People's Hospital, Eye diseases and optometry institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China.

To evaluate the treatment of vasoproliferative tumors of the retina (VPTR). Retrospective case series study. The clinical data of 20 VPTR patients (20 eyes) were retrospectively analyzed, including 2 eyes only treated by cryotherapy, 1 eye only treated by photocoagulation and 1 eye only treated by ruthenium-106 brachytherapy. Read More

Int Ophthalmol 2020 Apr 15. Epub 2020 Apr 15.

Department of Ophthalmology, National Taiwan University Hospital, Chun-Shan S. Rd., No. 7, Taipei, Taiwan.

Purpose: To investigate the characteristics of recurrent retinal detachment (RD) after diabetic vitrectomy (DV).

Methods: Consecutive cases underwent vitrectomy for recurrent RD after DV was collected and separated into the following four groups for analysis: rhegmatogenous RD (RRD), pure tractional RD (Proliferative Subgroup 1), combined RD with proliferative tissue within the equator (Proliferative Subgroup 2), and combined RD with both posterior and peripheral proliferations (Proliferative Subgroup 3).

Results: Of the 41 cases enrolled, retinal reattachment was achieved in 73. Read More

BMC Ophthalmol 2020 Apr 15;20(1):149. Epub 2020 Apr 15.

Address: Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, No1. Dongjiaominxiang street, Dongcheng District, Beijing, 100730, China.

Background: The development of ghost cell glaucoma in patients with proliferative diabetic retinopathy (PDR) after intravitreous injection (IV) was rare. Here we reported a series of patients with PDR who received Intravitreous Ranibizumab (IVR) and developed ghost cell glaucoma and analyzed the potential factors that might be related to the development of ghost cell glaucoma.

Methods: Retrospective case series study. Read More

Acta Ophthalmol 2020 Apr 12. Epub 2020 Apr 12.

Department of Ophthalmology, University Hospital, Dijon, France.

Purpose: To compare the risk of haemorrhagic complications in elective macular surgery between patients with no antithrombotic (AT) treatment (defined as patients with no history of AT therapy or who discontinued AT therapy) and patients who continued AT treatment during the surgery.

Methods: E-case report forms were prospectively recorded in a database before vitreoretinal surgery and 1 month after. Data on patient characteristics, surgical techniques, haemorrhagic complications and antithrombotic status were collected. Read More

Adv Ther 2020 May 9;37(5):2550-2559. Epub 2020 Apr 9.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Introduction: Proliferative vitreoretinopathy (PVR), which is regulated by growth factors and cytokines, is the leading cause of failure in vitreoretinal surgery. In this study, we aimed to investigate the role of the human serum and vitreous inflammation-related factors in the development of proliferative vitreoretinopathy (PVR).

Methods: Blood and vitreous samples were obtained from patients undergoing pars plana vitrectomy. Read More

Br J Ophthalmol 2020 Apr 3. Epub 2020 Apr 3.

Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Background/aim: To determine the preoperative ocular factors and surgical methods that led to best-corrected visual acuity (BCVA) after pars plana vitrectomy (PPV) or scleral buckling (SB) for rhegmatogenous retinal detachment (RRD).

Methods: This was a prospective, nationwide, multicentre, observational study. Data from the Japanese Retina and Vitreous Society registry from 2016 to 2017 were used to determine the association between preoperative clinical factors, surgical procedures and postoperative BCVA at 6 months. Read More

Curr Opin Ophthalmol 2020 May;31(3):192-198

Institute of Ophthalmology and Visual Science, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA.

Purpose Of Review: Retinal detachment initiates a series of events that lead to degenerative changes in retinal synaptic architecture as well as the well-known phenomena of gliosis and photoreceptor apoptosis. Retinal reattachment does not always result in complete visual recovery, even if the fovea is not directly involved in the detachment. Rho-kinase (ROCK) inhibitors may mitigate some of these deleterious changes including disruption of synaptic architecture, photoreceptor apoptosis, and initiation of the epithelial-mesenchymal transition that characterizes proliferative vitreoretinopathy (PVR). Read More

J Ocul Pharmacol Ther 2020 Jun 18;36(5):304-310. Epub 2020 Mar 18.

Department of Ophthalmology, Ruijin Hospital Affiliated Shanghai Jiaotong University School of Medicine, Shanghai, China.

To assess the clinical effects of preoperative, intraoperative, or preoperative combined with intraoperative intravitreal conbercept (IVC) injection in vitrectomy with silicone oil tamponade for severe proliferative diabetic retinopathy (PDR). Ninety-eight eyes of 98 severe PDR patients undergoing vitrectomy with silicone oil tamponade were randomly assigned to 3 groups: Group 1 (34 eyes) received IVC injections 3 to 5 days before surgery; Group 2 (35 eyes) received IVC injections at the end of surgery; and Group 3 (29 eyes) received IVC injections 3 to 5 days before and at the end of operation. Follow-up examinations were performed for 6 months. Read More

Am J Ophthalmol Case Rep 2020 Jun 30;18:100605. Epub 2020 Jan 30.

Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Purpose: To highlight the surgical and medical management used in an extensive globe penetrating injury caused by an acupuncture needle.

Observations: We report on a case of acupuncture treatment error resulting in needle penetration of the eye, retinal detachment, and progressive post-traumatic proliferative vitreoretinopathy (PVR). This patient required aggressive surgical management with multiple vitrectomies along with adjunctive intravitreal methotrexate to control ongoing PVR. Read More

Eur J Ophthalmol 2020 Jul 15;30(4):805-816. Epub 2020 Mar 15.

Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

The primary aim of this study was to summarize and illustrate the main structural cross-sectional optical coherence tomography findings encountered after vitreoretinal surgery for rhegmatogenous retinal detachment. This was a non-systematic review of literature on structural cross-sectional optical coherence tomography findings after vitreoretinal surgery for rhegmatogenous retinal detachment. Adequate illustrations of the main findings described were found after a retrospective analysis of imaging and charts of patients operated at the department where this study was performed. Read More

Niger J Clin Pract 2020 Mar;23(3):337-342

Department of Ophthalmology, Eye Foundation Hospital; Eye Foundation Retina Institute, 27 Isaac John Street, GRA, Ikeja, Lagos, Nigeria.

Aim: To present the anatomical and visual outcome and compare different techniques in the surgical treatment of proliferative vitreoretinopathy (PVR) in Nigerians.

Method: Comparative retrospective review of PVR grade C and D eyes that had vitreoretinal surgery with silicone oil between April 2005 and December 2012. Data was extracted from consecutive case notes after exclusion of eyes with PVR associated with proliferative diabetic retinopathy (PDR), proliferative sickle cell retinopathy (PSCR) and eyes with nonuse of silicone oil. Read More

Retin Cases Brief Rep 2020 Feb 28. Epub 2020 Feb 28.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.

Background/purpose: To report a diabetic patient with uveal effusion that developed proliferative diabetic retinopathy after unsuccessful scleral resection for the uveal effusion.

Case Report: A 50-year-old Japanese man with nonproliferative diabetic retinopathy and uveal effusion in his right eye underwent partial thickness sclerectomies at the four quadrants to treat the uveal effusion. These procedures reduced the amount of subretinal fluid and thus the choroidal and retinal detachment. Read More

Med Sci Monit 2020 Feb 27;26:e919871. Epub 2020 Feb 27.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).

BACKGROUND The aim of this study was to analyze the long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) network in human retinal tissues following detachment with proliferative vitreoretinopathy (PVR). MATERIAL AND METHODS Expression data of 19 human detached retinas with PVR and 19 normal retinas from postmortem donors were downloaded from Gene Expression Omnibust (GEO) database (GSE28133). The R package "limma" was utilized to discriminate the dysregulated lncRNA and mRNA profiles. Read More

Retina 2020 Feb 19. Epub 2020 Feb 19.

Department of Surgery, The Vision Center, Children's Hospital Los Angeles, Los Angeles, California.

Purpose: To report on the indications, outcomes, and complications of endoscopic vitrectomy in a large cohort of pediatric vitreoretinal patients.

Methods: This is a retrospective interventional case series consisting of 244 eyes of 211 patients aged 18 years or younger undergoing a total of 326 endoscopic vitrectomies from 2008 to 2017. A 23-gauge vitrectomy was performed with use of a 19-gauge endoscope. Read More

Eye (Lond) 2020 Feb 18. Epub 2020 Feb 18.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Background: To investigate the anatomical and functional results of silicone oil (SO) removal after an extended period of SO tamponade in eyes having received vitrectomy for proliferative diabetic retinopathy (PDR).

Methods: From May 2009 to August 2017, clinical records of patients who had vitrectomy for PDR and underwent SO removal were retrospectively reviewed. SO was in principle left in the eye for an extended period of time and would be removed promptly when complications relevant to SO rose, or at the same setting when other intraocular surgeries were performed. Read More

Chin Med J (Engl) 2020 Mar(6):664-669

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Background: Proliferative diabetic retinopathy (PDR) is a progressive stage of diabetic retinopathy featured by the formation of neovascular and proliferative membrane. Vascular endothelial growth factor (VEGF) acts as a pivot factor in the development of neovascularization. This study was to investigate the changes of intravitreal VEGF concentrations of severe PDR after intravitreal injection of conbercept (IVC) and its potential advantages to the following vitrectomy. Read More

Cutan Ocul Toxicol 2020 Jun 9;39(2):97-105. Epub 2020 Mar 9.

Department of Medical Biology, Trakya University, Edirne, Turkey.

Proliferative vitreoretinopathy (PVR) occurs in approximately 5-10% of patients after retinal detachment surgery. Neferine is a bis-benzylisoquinoline alkaloid found in the green seed embryos () of the lotus flower and has various properties, such as being antithrombotic, antioxidant, neuroprotective, anticancerous, and anti-inflammatory. Although the effects of neferine on the proliferation and migration of cancer cells have been partially shown, their possible role and the mechanism of action on PVR remain unclear. Read More

Isr Med Assoc J 2020 Feb;22(2):89-93

Department of Ophthalmology, Meir Medical Center, Kfar Saba, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: There are several ways to remove silicone oil (SO) from the vitreous cavity.

Objectives: To describe a simple, safe and inexpensive method of 2-port SO removal.

Methods: Medical charts of 33 patients who underwent SO removal combined with cataract extraction were retrospectively reviewed, from a cohort of 119 patients who had silicone oil removal. Read More

Retin Cases Brief Rep 2020 Feb 6. Epub 2020 Feb 6.

Department of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Purpose: To evaluate the efficacy of using preoperative and postoperative ultra-widefield optical coherence tomography) images in the treatment of proliferative vitreoretinopathy.

Methods: The preoperative and postoperative images of a 62-year-old man with proliferative vitreoretinopathy accompanied by a rhegmatogenous retinal detachment were analyzed.

Patient: At the initial examination, the vision was 20/400. Read More

J Cell Mol Med 2020 Mar 5;24(5):3217-3228. Epub 2020 Feb 5.

Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Proliferative vitreoretinopathy (PVR) is a severe ocular disease which results in complex retinal detachment and irreversible vision loss. The epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is considered to be critical in the pathogenesis of PVR. In this study, we focused on the potential impact of keratin 8 (KRT8) phosphorylation and autophagy on TGF-β2-induced EMT of RPE cells and explored the relationship between them. Read More

Clin Ophthalmol 2020 15;14:127-132. Epub 2020 Jan 15.

Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, Egypt.

Purpose: The purpose of this study is to compare anatomical and visual outcomes after using silicone oil (SO) or CF gas as tamponades after pars plana vitrectomy (PPV) for retinal detachment (RD) associated with giant retinal tears (GRTs).

Methods: A retrospective chart review was conducted for cases that underwent PPV for GRT-associated RD. We excluded eyes that had prior vitreoretinal surgery, a history of ocular trauma or worse than grade B proliferative vitreoretinopathy (PVR). Read More

Clin Ophthalmol 2020 9;14:53-60. Epub 2020 Jan 9.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose: To assess the causes and the ways of management of rhegmatogenous retinal detachment (RRD) after pars plana vitrectomy (PPV) performed in diabetic patients with advanced diabetic eye disease.

Methods: Retrospective review of the records of the patients who had undergone PPV for complicated proliferative diabetic retinopathy (PDR) was done. Cases with RRD after the PPV were analyzed in the study (n = 32). Read More

Vestn Oftalmol 2019 ;135(6):67-72

Moscow Regional Research and Clinical Institute, 61/2-11 Shchepkina St., Moscow, Russian Federation, 129110.

Diabetic macular edema (DME) is a serious complication of diabetic retinopathy. Numerous multicenter studies of the effectiveness of various treatment methods for DME do not give unambiguous recommendations for the treatment of refractory DME, and combinations of various forms of therapy continue to be actively studied.

Purpose: To study the effectiveness of the combination of intravitreal administration of the drug Ozurdex with subsequent individually selected laser therapy in the treatment of the proliferative stage of diabetic retinopathy in patients with concomitant chronic DME, and its relationship with morphological changes in the retina observed with optical coherence tomography. Read More

Ann Palliat Med 2020 Jan;9(1):82-89

Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing 100191, China.

Background: Younger patients who underwent vitrectomy for proliferative diabetic retinopathy (PDR) display more aggressive nature distinguished from the older patients. Preoperative anti-VEGF therapy has been widely used as an adjunct for PDR surgery. However, the effect of anti-VEGF administration in young diabetics has rarely been evaluated in previous studies. Read More