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Klin Monbl Augenheilkd 2021 Apr 30;238(4):396-402. Epub 2021 Apr 30.

Department of Ophthalmology, Cantonal Hospital St. Gallen, Switzerland.

Background: To report visual outcomes of anti-vascular endothelial growth factor (anti-VEGF) therapy for exudative age-related macular degeneration (AMD) in a real-life setting.

Patients And Methods: Retrospective case series of consecutive patients treated with either ranibizumab and/or aflibercept for monolateral or bilateral exudative AMD. A physician established the indication for treatment and administered the injections. Read More

Int J Mol Sci 2021 Apr 15;22(8). Epub 2021 Apr 15.

Departments of Ophthalmology, Faculty of Medicine, University of Yamanashi, Kofu 400-8510, Japan.

Few studies report drusenoid pigment epithelial detachment (DPED) in Asians. In this multicenter study, we report the clinical and genetic characteristics of 76 patients with DPED, and, for comparison, 861 patients with exudative age-related macular degeneration (AMD) were included. On the initial presentation, the mean best-corrected visual acuity was 0. Read More

Int J Ophthalmol 2021 18;14(4):630-632. Epub 2021 Apr 18.

Department of Glaucoma, Disha Eye Hospitals Pvt.Ltd., Barrackpore, Kolkata 700120, West Bengal, India.

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

Am J Ophthalmol 2021 Apr 9. Epub 2021 Apr 9.

the Department of Medicine, Texas A&M University, College Station, TX, USA.

Purpose: To determine classification criteria for Vogt-Koyanagi-Harada (VKH) disease DESIGN: Machine learning of cases with VKH disease and 5 other panuveitides.

Methods: Cases of panuveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Read More

Ophthalmic Genet 2021 Apr 12:1-8. Epub 2021 Apr 12.

Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Sapienza University of Rome, Faculty of Medicine and Psychology, St. Andrea Hospital, Rome, Italy.

: Diffuse choroidal hemangioma (DCH) is a benign vascular tumor that is characteristically found in the Sturge-Weber syndrome (SWS). Recent genetic discoveries demonstrate that DCH occurs sporadically from an activating mutation in at codon . Mutations in or result in dysregulation of the mitogen-activated protein kinase, which influences gene transcription and results in cellular proliferation. Read More

Int J Retina Vitreous 2021 Apr 1;7(1):27. Epub 2021 Apr 1.

Ophthalmology Department, Federal University of São Paulo (Unifesp-EPM), Rua Botucatu, 822, São Paulo, SP, 04023-062, Brazil.

Background: To report a case of acute exudative polymorphous paraneoplastic vitelliform maculopathy in a patient with a history of choroidal melanoma, with metastases to the pancreas, liver, and central nervous system.

Case Presentation: A 63-year-old patient, with a history of enucleation of the right eye due to choroidal melanoma, complained of progressive visual loss during a follow-up visit. Fundoscopic examination revealed multiple small areas of serous retinal detachment scattered throughout the posterior pole and ancillary tests confirmed the diagnosis of acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM). Read More

BMJ Case Rep 2021 Mar 31;14(3). Epub 2021 Mar 31.

Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India.

A 26-year-old man presented with diminution of vision in the left eye associated with malaise and occasional mild fever. On fundus examination, the patient had left eye inferior bullous retinal detachment with choroidal granuloma. Systemic examination revealed a non-tender swelling on the right wrist. Read More

J Med Case Rep 2021 Mar 28;15(1):175. Epub 2021 Mar 28.

Department of Ophthalmology, Saitama Medical Center, Dokkyo Medical University, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, 343-8555, Japan.

Background: Reversible cerebral vasoconstriction syndrome is characterized by severe headache with reversible segmental constriction of the cerebral arteries. We present details on a patient with reversible cerebral vasoconstriction syndrome who initially visited an ophthalmologist because of visual symptoms.

Case Presentation: A 34-year-old Japanese woman complained of sustained headache and insomnia starting 2 days after her first childbirth. Read More

J Int Med Res 2021 Mar;49(3):300060520964373

Department of Ophthalmology, The 900th Hospital of Joint Logistic Support Force, PLA (Clinical Medical College of Fujian Medical University, Dongfang Hopsital Affiliated to Xiamen University), Fuzhou, China.

This report describes a patient who had acute lymphocytic leukemia with exudative retinal detachment (RD), which mimicked Vogt-Koyanagi-Harada disease (VKH). A 61-year-old woman presented with painless loss of vision in the left eye. Fundus examination revealed RD in her left eye. Read More

Cureus 2021 Feb 19;13(2):e13444. Epub 2021 Feb 19.

Department of Ophthalmology, King Abdulaziz University, Jeddah, SAU.

Eclampsia is a severe hypertensive disease accompanied by tonic-clonic convulsions in the second half of pregnancy or during delivery in the absence of other aetiology. The association between eclampsia and serous retinal detachment is not common. We report a case of a 20-year-old primipara with eclampsia who developed bilateral exudative retinal detachment after delivery. Read More

Medicine (Baltimore) 2021 Mar;100(11):e25189

Department of Ophthalmology, Medical University of Bialystok, Poland.

Rationale: In this report, we present an extremely rare case of recurrent monocular exudative retinal detachment without concomitant ocular metastases. This turned out to be the first symptom of squamous cell lung cancer.

Patient Concerns: A 63-year-old woman was referred to our ophthalmology clinic by her primary care physician with a complaint of deteriorating vision in her right eye that had started four months prior, without concomitant pain. Read More

Int Med Case Rep J 2021 3;14:139-144. Epub 2021 Mar 3.

Ophthalmology Unit, Department of Surgery, Abia State University Teaching Hospital, Aba, Abia State, Nigeria.

Introduction: Chronic renal failure (CRF) is a multi-systemic disease affecting different organ systems of the body. Ocular manifestations of chronic renal disease include squint, subconjunctival hemorrhage, vitreous hemorrhage, neovascular glaucoma, cataracts and retinal detachment. These result in visual impairment or blindness. Read More

Clin Exp Optom 2021 Feb 25:1-3. Epub 2021 Feb 25.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield University Hospitals NHS Foundation Trust, Sheffield, UK.

Clin Exp Rheumatol 2021 03 5. Epub 2021 Mar 5.

Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Spain.

Objectives: Rapid control of intraocular inflammation in non-infectious uveitis (NIU) is mandatory to avoid irreversible structural and functional damage. In this study, we assessed the efficacy and safety of intravenous methylprednisolone (IVMP) pulses in the treatment of NIU.

Methods: A retrospective case series of 112 patients who received IVMP for the treatment of NIU, either isolated or associated with different underlying diseases, was studied. Read More

Medicine (Baltimore) 2021 Mar;100(9):e24633

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan Province.

Rationale: Familial exudative vitreoretinopathy (FEVR) is an inherited disorder, which is mostly reported to be associated with the mutation of genes involved in the Wnt signaling pathway related to β-catenin. To the best of our knowledge, the involvement of Adams-Oliver syndrome (AOS) genes in FEVR patients have not been reported before.

Patient Concerns: Two patients with FEVR presented with microcephaly. Read More

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Advanced eye centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India

A 47-year-old man presented to our retina clinic with gradual onset diminution of vision in his right eye for the last 3 months. Anterior segment evaluation was normal in both eyes. Fundus evaluation showed the presence of leopard spot appearance in the right eye with inferior exudative retinal detachment. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Mar 2. Epub 2021 Mar 2.

Department of Ophthalmology, Centro Hospitalar de São João Hospital, Avenida Prof. Hernâni Monteiro, 4202 - 451, Porto, Portugal.

Purpose: To identify predictive factors for RPE tear remodelling and its correlation with functional and morphological outcomes.

Methods: Retrospective longitudinal study of patients with retinal pigment epithelium (RPE) tears secondary to age-related macular degeneration (AMD). Imaging was performed using spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF). Read More

Optom Vis Sci 2021 Mar;98(3):206-211

Significance: Acute retinal necrosis (ARN) may occur after intravitreal ranibizumab (IVR) treatment for patients with exudative age-related macular degeneration (AMD). Awareness of this unusual but devastating complication after IVR is needed. Early identification may help provide timely antiviral treatment and prevent irreversible visual loss. Read More

Int Ophthalmol 2021 May 21;41(5):1835-1844. Epub 2021 Feb 21.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-0856, Japan.

Purpose: To report the outcomes of pars plana vitrectomy in cases with breakthrough vitreous hemorrhage (VH) secondary to exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy. We also investigated the relationship between the preoperative b-mode ultrasonographic findings and the postoperative visual acuity to determine if the ultrasonographic findings can predict the surgical outcome after pars plana vitrectomy.

Methods: This was a retrospective, interventional, case series. Read More

Surv Ophthalmol 2021 Feb 2. Epub 2021 Feb 2.

Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy.

Choroidal rupture is a posterior segment affliction following a traumatic event that results in a break in the retinal pigment epithelium, Bruch membrane, and the underlying choriocapillaris. The visual prognosis may be extremely poor when involving the macular area or in cases with major comorbidities. On funduscopic examination the rupture appears as a whitish/yellowish curvilinear or crescent-shaped lesion with forked or tapered endings. Read More

Clin Ophthalmol 2021 29;15:367-373. Epub 2021 Jan 29.

Al Mashreq Eye Center, Cairo, Egypt.

Background: Coats' disease is a rare entity with retinal vascular telangiectasia that can progress to exudative retinal detachment, neovascular glaucoma, and a blind painful eye requiring enucleation. Despite recent therapeutic advances decreasing the need for enucleation, no consensus exists about the optimum management of exudative Coats' disease. The use of intravitreal anti-vascular endothelial growth factor agents as an adjunct to ablation therapy has been shown to achieve favorable outcomes, but some reports suggest an increased incidence of vitreoretinal (VR) fibrosis and tractional retinal detachment (TRD). Read More

Ocul Immunol Inflamm 2021 Feb 4:1-7. Epub 2021 Feb 4.

Department of Ophthalmology, Sapporo City General Hospital , Sapporo, Japan.

Purpose: To report a case of a neonate with acute retinal necrosis, lens vacuoles, and encephalitis associated with herpes simplex virus (HSV) infection.

Design: Case report.

Methods: Retrospective chart review. Read More

Int Ophthalmol 2021 May 4;41(5):1635-1642. Epub 2021 Feb 4.

Department of Ophthalmology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China.

Background: To explore the treatment efficacy of the combination of preoperative intravitreal ranibizumab (IVR) and postoperative intravitreal triamcinolone acetonide (IVTA) in patients undergoing pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR).

Methods: A retrospective comparative study was performed on 128 eyes of 128 patients who had PDR and underwent PPV. Patients who received a single PPV were assigned to Group A. Read More

Eur J Ophthalmol 2021 Feb 2:1120672121991391. Epub 2021 Feb 2.

The Francis I. Proctor Foundation, UCSF School of Medicine, San Francisco, CA, USA.

Purpose: To describe the prevalence and causes of clinically detectable uveitic serous retinal detachment (SRD).

Methods: Retrospective chart review of a large clinic-based series.

Results: Serous retinal detachment was present in 78 of the 2761 (2. Read More

Retin Cases Brief Rep 2021 Jan 18. Epub 2021 Jan 18.

Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany Department of Ophthalmology, Helios University Hospital Wuppertal, University of Witten-Herdecke, Germany Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Germany.

Purpose: To report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) over 30 months follow-up.

Methods: Multimodal imaging including ultrawidefield color fundus photography, blue light fundus autofluorescence, swept-source optical coherence tomography, fluorescein and ICG angiography.

Results: A 49-year old female presented with decreased vision two months after bladder cancer surgery. Read More

Middle East Afr J Ophthalmol 2020 Jul-Sep;27(3):188-190. Epub 2020 Oct 30.

Department of Ophthalmology, King Fahad Medical City, Riyadh, Saudi Arabia.

von Hippel-Lindau (VHL) is a multisystemic inherited disease which most commonly affects the retina and central nervous system. The hallmark retinal manifestation of VHL in the eye is retinal capillary hemangioblastoma (RCH). Significant visual morbidity can result from exudative retinal detachments (ERDs) or tractional retinal detachments. Read More

Middle East Afr J Ophthalmol 2020 Jul-Sep;27(3):185-187. Epub 2020 Oct 30.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

We report the case of a 36-year-old male patient known to have ulcerative colitis on adalimumab treatment for 2 years who presented with initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease. Uveitis was treated successfully with systemic corticosteroids combined with mycophenolate mofetil. The patient had complete resolution of posterior segment inflammation and exudative retinal detachment. Read More

Int J Surg Case Rep 2021 Feb 15;79:227-230. Epub 2021 Jan 15.

Pathology & Laboratory Medicine Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Introduction And Importance: Juxtapapillary retinal capillary hemangiomas (RCHs) are vascular hamartomas that occur adjacent to the optic disc. Juxtapapillary RCHs can be found as an isolated finding or in association with Von Hippel-Lindau (VHL) disease. VHL is a dominantly inherited disease that is characterized by multiple intracranial and retinal hemangioblastomas along with benign and malignant visceral tumors. Read More

Arch Soc Esp Oftalmol 2021 Jan 19. Epub 2021 Jan 19.

Servicio de Oftalmología, Hospital General Obispo Polanco, Teruel, España.

A 53-year-old male with no systemic disorders, other than controlled arterial hypertension, presented with asymptomatic, bilateral neurosensory retinal detachment (NRD) detected during a routine revision. The patient reported the use of tadalafil (a phosphodiesterase-5 inhibitor [PDE5I]) for erectile dysfunction. Following suspension of the drug, subretinal fluid reabsorption was confirmed, with the persistence of chronic alterations in the optical coherence tomography (OCT) and the visual field. Read More