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J Ophthalmol 2020 11;2020:6231269. Epub 2020 May 11.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: Bilateral choroidal ganglioneuroma is extremely rare, and no cases have been described in the literature. Multimodal images are crucial for its diagnosis. Here, we evaluated multimodal images in the early stage of choroidal ganglioneuroma. Read More

BMC Ophthalmol 2020 May 24;20(1):198. Epub 2020 May 24.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Posterior choroidal leiomyoma is an extremely rare tumor, to our knowledge, less than 10 cases reported in the literature. The definite diagnosis can be confirmed by immunohistochemistry, and local resection is preferable to enucleation for the posterior choroidal leiomyoma.

Case Presentation: Two adult Asian women presented with progressive vision loss in their right eyes. Read More

Medicine (Baltimore) 2020 May;99(20):e20249

Department of Ophthalmology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University.

Introduction: Coats disease is a sporadic, retinal vascular abnormality, causing blindness. Several interventional methods, including laser photocoagulation, have been proposed; however, the use of intravitreal dexamethasone in refractory Coats disease is not well described.

Patient Concerns: A 38-year-old man presented with a painless reduction in visual acuity in his right eye, commencing 15 days prior to initial assessment. Read More

Am J Ophthalmol Case Rep 2020 Sep 22;19:100715. Epub 2020 Apr 22.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To describe an infant with Adams Oliver syndrome (AOS) with ocular signs similar to familial exudative vitreoretinopathy.

Observations: A full-term female infant presented with a congenital scalp defect, hypoplasia of the fingers and toes along with a radial retinal fold in the right eye and tractional retinal detachment in the left eye. Fluorescein angiography findings included peripheral retinal nonperfusion, irregular vascular sprouting beyond the vascular-avascular junction, pinpoint areas of hyperfluorescence as well as late peripheral and posterior vascular leakage. Read More

Respir Med Case Rep 2020 4;30:101074. Epub 2020 May 4.

Unit of Ocular Oncology, Neuromuscular and Sense Organs Department, Careggi University Hospital, Florence, Italy.

A 64-year-old man, diagnosed with a retinal detachment of his left eye, was sent to our hospital to evaluate vitreoretinal surgery. Left eye best-corrected visual acuity was hand motion. Fundus examination showed a voluminous slightly pigmented choroidal neoformation with secondary retinal detachment. Read More

Ophthalmol Retina 2020 Mar 18. Epub 2020 Mar 18.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Purpose: To describe the clinical and imaging characteristics, pathologic features, and management options of retinal pigment epithelium (RPE) adenoma/adenocarcinoma.

Design: Retrospective case series.

Participants: Fifty-one patients with RPE adenoma/adenocarcinoma. Read More

Am J Ophthalmol Case Rep 2020 Jun 23;18:100718. Epub 2020 Apr 23.

Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo St, Los Angeles, CA, USA.

Graefes Arch Clin Exp Ophthalmol 2020 May 8. Epub 2020 May 8.

Department of Retina and Pediatric Ophthalmology, Hôpital Fondation Adolphe de Rothschild, 29 rue Manin, 75019, Paris, France.

Purpose: To evaluate the outcome for vitreoretinal surgery in children with familial exudative vitreoretinopathy (FEVR) and to evaluate the risk factors associated with failure.

Methods: This is a retrospective interventional case series of 43 consecutive eyes (34 patients) with vitreoretinal surgery for FEVR. Ocular status prior to intervention and at last follow-up and all surgical steps were recorded. Read More

BMC Ophthalmol 2020 May 5;20(1):178. Epub 2020 May 5.

Department of ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

Background: To investigate aqueous humour (AH) cytokine profiles in eyes with Coats disease and analyze the association between cytokine concentrations and the severity of the disease.

Methods: The study included 36 patients (36 eyes) with Coats disease and 15 control patients (15 eyes) with congenital cataract. AH samples were obtained preoperatively and the concentrations of 22 different cytokines were measured through Cytometric Bead Array technology. Read More

Vestn Oftalmol 2020 ;136(2):143-151

N.I. Pirogov Russian National Research Medical University, Moscow, Russia.

Retinopathy of prematurity (ROP) is a severe vascular proliferative disease. The appearance of signs of intrauterine infection in the setting of ROP may aggravate the severity of the disease course and lead to development of complications. Two children with residual ROP effects were observe to have delayed manifestations of intrauterine infection. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19623

Departments of Surgery (Ophthalmology) King Hussein Cancer Center.

To report on the characteristics and outcome of management of Coats' disease, and to describe a novel surgical technique for management of stage 3B with total retinal detachment (RD) by scleral external drainage with anterior chamber (AC-maintainer) placement before the drainage without pars plana vitrectomy.A retrospective study of 26 eyes from 25 Coats' patients. Outcome measures included: demographics, presentation, laterality, stage, treatment, and outcome. Read More

Zhonghua Yan Ke Za Zhi 2020 Apr;56(4):272-278

Department of Ophthalmology, Peking University People's Hospital, Eye diseases and optometry institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry, Peking University Health Science Center, Beijing 100044, China.

To evaluate the treatment of vasoproliferative tumors of the retina (VPTR). Retrospective case series study. The clinical data of 20 VPTR patients (20 eyes) were retrospectively analyzed, including 2 eyes only treated by cryotherapy, 1 eye only treated by photocoagulation and 1 eye only treated by ruthenium-106 brachytherapy. Read More

Am J Ophthalmol Case Rep 2020 Jun 31;18:100682. Epub 2020 Mar 31.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Purpose: Two diabetic case reports of serous retinal detachment (SRD) accompanied by pachychoroid in hypotony maculopathy after trabeculectomy for neovascular glaucoma (NVG).

Observations: Case 1: A 66-year-old female with stage 3 NVG and decreased vision acuity in the left eye. After trabeculectomy, postoperative laser suture lysis (LSL) resulted in development of hypotony maculopathy, followed by pachychoroid and SRD. Read More

Am J Ophthalmol Case Rep 2020 Jun 13;18:100662. Epub 2020 Mar 13.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, 900 NW 17th Street, Miami, FL, 33136, USA.

Purpose: To report 2 cases of pediatric vitreoretinal disease in the setting of Turner's syndrome.

Observations: A 4-year-old girl with Turner's syndrome was referred for evaluation of a tractional retinal detachment in the right eye. Fundoscopic examination disclosed temporal dragging of the macula in the right eye, and vascular nonperfusion in the right and left eyes. Read More

BMC Ophthalmol 2020 Mar 17;20(1):108. Epub 2020 Mar 17.

Department of Ophthalmology, Faculty of Medicine, Saitama Medical University, 38 Moro-Hongo Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Background: Macular hole (MH) is a retinal break in the fovea involving partial or complete dehiscence of the neural retinal layers affecting the visual quality by decreasing visual acuity (VA) and visual deformation. We describe a case of secondary MH associated with submacular hemorrhage (SMH) due to polypoidal choroidal vasculopathy (PCV), which showed spontaneous closure.

Case Presentation: A 67-year-old man developed decreased VA in his right eye due to an SMH. Read More

Am J Ophthalmol Case Rep 2020 Jun 15;18:100618. Epub 2020 Feb 15.

Francis I. Proctor Foundation, 95 Kirkham St, University of California, San Francisco, CA, 94143, USA.

Purpose: This is a retrospective case report illustrating the diagnostic and therapeutic challenges associated with a chronic rhegmatogenous retinal detachment masquerading as a severe panuveitis with intense anterior chamber inflammation. We have included clinical features, anterior segment and fundus photography, B-scan ultrasonography, fluorescein angiography, and intraoperative findings.

Observations: A 26-year-old male presented with features of unilateral panuveitis: hypotony, anterior segment inflammation (posterior synechiae and anterior chamber cell with fibrin clumping), diffuse choroidal thickening, and retinal detachment. Read More

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):253-256. Epub 2020 Jan 29.

Vitreoretinal Division, King Khaled Eye Specialist Hospital (KKESH), Riyadh, Saudi Arabia.

Three cases of peripheral exudative hemorrhagic chorioretinopathy (PEHCR), which mimicked other retinal pathologies, were reported. Different preliminary diagnoses were made initially, but thorough examination combined with the appropriate investigations led to the final diagnosis of PEHCR. Despite the rare occurrence of PEHCR, it must be included in the differential diagnosis for peripheral retinal diseases. Read More

J Fr Ophtalmol 2020 Mar 5. Epub 2020 Mar 5.

Pavlov First Saint Petersburg State Medical University, St Petersburg, Russia. Electronic address:

Purpose: To describe and analyze clinical findings in a patient with recurrent idiopathic acute exudative polymorphous vitelliform maculopathy (AEPVM), followed in detail, and to propose the diagnostic and follow-up algorithm.

Design: Retrospective observational analysis.

Patient: A young adult male patient diagnosed with idiopathic AEPVM who developed two relapses in a 12-month period eight years after the initial onset. Read More

Am J Ophthalmol 2020 Feb 27. Epub 2020 Feb 27.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

Purpose: The purpose of this study was to investigate the etiology and clinical features of nontraumatic rhegmatogenous retinal detachment (RRD) in children.

Design: Consecutive, cross-sectional study.

Methods: In this study, 112 operative eyes of 102 patients ≤18 years of age with nontraumatic RRD were included. Read More

Am J Ophthalmol Case Rep 2020 Mar 1;17:100583. Epub 2020 Jan 1.

Tennessee Retina, 345 23rd Ave N, Ste 350, Nashville, TN, 37203, USA.

Purpose: Herein we present a case of giant cell arteritis presenting with nodular posterior scleritis and exudative retinal detachment mimicking a choroidal mass.

Observations: A 67-year-old man presented with sudden onset left-sided periorbital pain, blurry vision, and a choroidal lesion in the posterior pole. Despite treatment with high-dose oral prednisone for suspected nodular posterior scleritis mimicking a choroidal mass, the vision in his left eye did not recover, and he developed optic nerve pallor on exam. Read More

J Ophthalmic Vis Res 2020 Jan-Mar;15(1):78-94. Epub 2020 Feb 2.

Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Retinal hemangioblastoma (also referred to as retinal capillary hemangioma) is a benign lesion originating from the endothelial and glial components of the neurosensory retina and optic nerve head. Historically known as a manifestation of the von Hippel-Lindau (VHL) disease, it can be seen as an isolated finding or in association with some rare ocular conditions. In addition to characteristic ophthalmoscopic features, results of numerous ancillary tests including angiography, ultrasound, optical coherence tomography, and genetic tests may support the diagnosis and differentiate it from similar conditions. Read More

J Physiol Pharmacol 2019 Oct 30;70(5). Epub 2020 Jan 30.

Department of Opthalmology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland.

Age-related macular degeneration (AMD) is a leading cause of central visual loss in people aged over 50 years in well developed countries. Although the anti-vascular endothelial growth factor (VEGF) therapy has become a standard treatment for exudative AMD, its effectiveness may be limited in some cases. We aimed to assess the prevalence of non-responsiveness and tachyphylaxis to anti-VEGF drugs in patients with exudative AMD. Read More

Ophthalmologica 2020 Jan 31:1-10. Epub 2020 Jan 31.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Aims: To analyze ocular fundus characteristics of patients finally diagnosed with fibrinous central serous chorioretinopathy (CSC) using multimodal imaging and compare the characteristics with images of other confusable exudative maculopathies.

Methods: We retrospectively reviewed the records from 189 patients with CSC and found records on 16 patients with fibrinous CSC. Some of these 16 patients were misdiagnosed with another exudative maculopathy and were treated inappropriately. Read More

Can J Ophthalmol 2020 Jan 13. Epub 2020 Jan 13.

Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, India.

Objective: The aim of this study was to evaluate various techniques of surgical treatment of retinal detachment associated with familial exudative vitreoretinopathy (FEVR) and the factors affecting the anatomical and visual outcome.

Design: Retrospective case series.

Participants: Patients diagnosed with FEVR associated retinal detachment and operated for the same between January 2004 and September 2017. Read More

Rom J Ophthalmol 2019 Oct-Dec;63(4):397-402

Department of Ophthalmology, Parkhayat Hospital, Afyon, Turkey.

Posterior scleritis in a child is a rare condition. High-resolution imaging techniques in the course of posterior scleritis have not been published extensively in literature. The authors reported a case of posterior scleritis in a 12-year-old child to demonstrate multimodal imaging techniques in the course of development and improvement of the disease. Read More

Retin Cases Brief Rep 2020 Jan 6. Epub 2020 Jan 6.

Clínicas OFTALVIST, Valencia, Spain.

Purpose: To describe the evolution of a case of adult-onset Coats disease and the results of treatment with intravitreal ranibizumab and laser photocoagulation.

Methods: Observational case report.

Case Report: A 17-year-old girl presented with vision loss in her right eye (20/50) showing aneurysmatic and abnormal telangiectatic vessels associated with profuse lipid exudation and serous retinal detachment within the temporal posterior pole. Read More

Eur J Ophthalmol 2019 Dec 25:1120672119896286. Epub 2019 Dec 25.

Department of Surgical Sciences, Eye Clinic, University of Torino, Torino, Italy.

Purpose: We present the case of a 22-year-old woman, diagnosed as having atypical hemolytic uremic syndrome with a hypertensive crisis, who presented a bilateral serous retinal detachment.

Case Description: A 22-year-old woman, diagnosed as having atypical hemolytic uremic syndrome, was referred for blurred vision in both eyes, evolving over 7 days. Treatment including hemodialysis, plasma exchange, systemic steroids, antihypertensive medications and eculizumab was started 1 month prior to referral. Read More

Can J Ophthalmol 2019 12 9;54(6):647-652. Epub 2019 Apr 9.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ont.; Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ont.; Department of Ophthalmology, The University of Hong Kong, Hong Kong.. Electronic address:

Objective: To report visual outcomes for children with Coats' disease after treatment.

Design: Retrospective case series.

Participants: Pediatric patients with Coats' disease treated between 2000 and 2018 at a tertiary care pediatric hospital. Read More

Genet Test Mol Biomarkers 2019 Dec;23(12):850-856

Shenzhen Eye Hospital, Shenzhen, China.

To report a clinical and genetic investigation of a southern Chinese family with X-linked recessive exudative vitreoretinopathy and vitreous hemorrhage. We collected clinical data from a proband and his family. Complete ophthalmic examinations were carried out on the proband. Read More

Retin Cases Brief Rep 2019 Nov 28. Epub 2019 Nov 28.

Department of Ophthalmology, Edward Harkness Eye Institute, Columbia University Medical Center, New York, New York.

Purpose: To describe the first known case of an extracorporeal membrane oxygenation (ECMO)-related complication in an adult.

Methods: Case report.

Results: A 34-year-old man awaiting a lung transplant for interstitial lung disease was connected to an ECMO circuit as a bridge to lung transplant, with a drainage catheter attached to his right internal jugular vein. Read More

Ophthalmic Genet 2019 12 28;40(6):581-583. Epub 2019 Nov 28.

Department of Ophthalmology, Clinical Medical College, Yangzhou University, Yangzhou, China.

Retin Cases Brief Rep 2019 Nov 21. Epub 2019 Nov 21.

Department of Ophthalmology, Oftalmico Hospital, ASST-Fatebenefratelli-Sacco, Milan, Italy.

Purpose: To report the case of a patient with peripapillary pachychoroid syndrome and recurrent and spontaneous resolving peripapillary neurosensory retinal detachments associated with pulmonary arterial hypertension.

Methods: Case report imaged with spectral-domain optical coherence tomography, swept-source optical coherence tomography angiography, fundus autofluorescence, and fluorescein and indocyanine green angiography.

Results: A 47-year-old woman presented with unilateral blurred vision and metamorphopsia in her left eye and was diagnosed with peripapillary serous retinal detachments associated with peripapillary pachychoroid syndrome. Read More

Case Rep Ophthalmol 2019 Sep-Dec;10(3):374-378. Epub 2019 Nov 1.

Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

We report a case of bilateral serous retinal detachment in a patient with rod-cone dystrophy caused by mutation of BEST1. This followed creatine monohydrate use as a dietary supplement. A 39-year-old male with rod-cone dystrophy and low hyperopia developed extensive bilateral exudative retinal detachment following creatine monohydrate diet supplementation. Read More

Case Rep Ophthalmol 2019 Sep-Dec;10(3):339-343. Epub 2019 Oct 16.

Department of Ophthalmology, Clinic of Ophthalmology and Ocular Oncology, Jagiellonian University Medical College, Krakow, Poland.

We aimed to present a unique case of a child with an optic disc granuloma with exudative retinal detachment as a manifestation of ocular toxocariasis. The response to systemic therapy was assessed using deep range imaging optical coherence tomography. This imaging technique was the most accurate for identification of retinal, macular and vitreous changes associated with this intraocular pathology. Read More

Eur J Ophthalmol 2019 Nov 20:1120672119889007. Epub 2019 Nov 20.

Department of Medical Retina, Hospital Universitari i Politecnic La Fe, Valencia, Spain.

A case of a young Caucasian male who presented bilateral papilledema is described. He was misdiagnosed with bilateral anterior optic neuritis, developing panuveitis and exudative bilateral retinal detachment after being treated with megadoses of corticosteroids. He was finally diagnosed with ocular syphilis and treated with intravenous aqueous crystalline penicillin for 14 days, with complete resolution of his symptoms. Read More

Lasers Med Sci 2019 Nov 19. Epub 2019 Nov 19.

Department of Biostatistics, İnönü University Turgut Özal Medical Center, Malatya, Turkey.

Purpose: To compare the anterior and posterior segment complications of diode (810 nm) laser photocoagulation (LPC) and Nd:YAG (532 nm green) LPC in the treatment of retinopathy of prematurity (ROP).

Patients And Methods: The 84 eyes of 43 patients treated with diode LPC (group 1) and 58 eyes of 31 patients treated with Nd:YAG LPC (group 2) for ROP in our clinic were enrolled in the study. Medical records of all patients were investigated retrospectively. Read More

GMS Ophthalmol Cases 2019 25;9:Doc33. Epub 2019 Oct 25.

Cornea, Ispahani Islamia Eye Institute and Hospital, Dhaka, Bangladesh.

Ahmed glaucoma valve implant appears to be a relatively useful drainage device in eyes with glaucoma secondary to Sturge-Weber syndrome (SWS). However, early postoperative choroidal and exudative retinal detachment may occur from a rapid expansion of the choroidal hemangioma with effusion of fluid into the suprachoroidal and subretinal spaces. We report the case of a ten-year-old boy who had SWS with choroidal haemangioma and secondary glaucoma. Read More

Case Rep Ophthalmol 2019 May-Aug;10(2):213-220. Epub 2019 Jul 23.

Save Sight Institute, The University of Sydney, Sydney, New South Wales, Australia.

Background: Currently, transvitreal fine-needle aspiration biopsy is the most widely used tissue biopsy technique in cases of suspected intraocular lymphoma due to its relative simplicity and low trauma. The small sample produced, however, may be inadequate for diagnostic and prognostic analyses due to mechanical artefacts, insufficient material, or sampling errors. Small case series have demonstrated choroidal biopsy via vitrectomy to be safe and effective. Read More

Rom J Ophthalmol 2019 Jul-Sep;63(3):231-237

Department of Ophthalmology, Başkent University Zübeyde Hanım Research Hospital, İzmir, Turkey.

Age related macular degeneration (ARMD) remains a serious cause of vision loss in elderly people worldwide. The purpose of the study is to investigate the fellow eye of the patients with exudative ARMD using optical coherence tomography angiography (OCTA). We conducted a retrospective study from the data of patients with exudative ARMD. Read More

Br J Ophthalmol 2019 Nov 1. Epub 2019 Nov 1.

Department of Ophthalmology, University Hospital Essen, Essen, Germany.

Background: To demonstrate histopathological findings in retinoblastoma eyes enucleated after intra-arterial chemotherapy (IAC) with special emphasis on vascular toxicity and local tumour control.

Methods: Retrospective study with a consecutive series of 23 retinoblastoma eyes enucleated after IAC where histopathological work-up was available.

Results: From November 2010 to June 2019 23 eyes were enucleated after the attempt of eye salvaging therapy with IAC using melphalan. Read More

Br J Ophthalmol 2020 Jun 23;104(6):874-878. Epub 2019 Oct 23.

Department of Ophthalmology, Pasteur 2 University Hospital, Nice, France.

Purpose: Peripheral exudative haemorrhagic chorioretinopathy (PEHCR) is a rare disorder that is often misdiagnosed. The aim of this study was to better characterise PEHCR and to assess treatment options.

Material And Methods: Retrospective multicentric chart review. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 09;50(9):e242-e249

Background And Objective: To describe and present the reliability and reproducibility of a new software, Retinal Volume Analyzer (ReVAnalyzer), for pigment epithelium detachment (PED) volume quantification.

Patients And Methods: This is a retrospective study including patients with PEDs secondary to exudative age-related macular degeneration (AMD). Macular volume scans on spectral-domain optical coherence tomography on enhanced depth imaging mode were performed in all eyes. Read More

Cureus 2019 Aug 4;11(8):e5319. Epub 2019 Aug 4.

Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.

In this review article, we aimed to analyze the available data on the ocular manifestations of von Hippel-Lindau (VHL) disease. In this disease, the VHL protein becomes inactivated by germline mutations of the tumor suppressor gene on chromosome 3p25-26, resulting in an overproduction of VEGF in non-hypoxic conditions. Ocular manifestations are expected in roughly half of VHL patients. Read More

Medicine (Baltimore) 2019 Oct;98(40):e17441

Department of Ophthalmology, Zhejiang Medicine and Western Medicine Integrated Hospital (Hangzhou Red-Cross Hospital), Hangzhou, Zhejiang, P.R. China.

Rationale: Although metastatic tumor is the most common intraocular malignancy, choroidal metastasis from gastric cancer is relatively rare. We present the exact course of a spontaneous rupture of the eyeball with choroidal metastasis from gastric carcinoma (GC) and the applied surgical interventions.

Patient Concerns: A 59-year-old male presented with pain and vision loss on his left eye for 6 months. Read More

Dev Dyn 2019 12 21;248(12):1243-1256. Epub 2019 Oct 21.

Department of Pediatrics, IWK Health Centre/Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Familial exudative vitreoretinopathy (FEVR) is a rare congenital disorder characterized by a lack of blood vessel growth to the periphery of the retina with secondary fibrovascular proliferation at the vascular-avascular junction. These structurally abnormal vessels cause leakage and hemorrhage, while the fibroproliferative scarring results in retinal dragging, detachment and blindness. Mutations in the FZD4 gene represent one of the most common causes of FEVR. Read More

Int J Ophthalmol 2019 18;12(9):1444-1449. Epub 2019 Sep 18.

Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

Aim: To assess surgical outcomes of a novel method of transscleral drainage of subretinal fluid using a 25-gauge trocar-cannula with a self-closing valve (DTV) in patients with severe exudative retinal detachment (ERD) in Coats disease.

Methods: Retrospective consecutive cases of 20 patients (20 eyes) of severe ERD due to Coats disease (stage 3B) in total 156 Coats patients between June 2015 and April 2019 were included in this study. The participants were aged 1 to 10y with a mean age of 3. Read More

Cesk Slov Oftalmol 2019 ;75(2):80-84

Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is relatively rare and especially less known and therefore less often diagnosed condition of the retina periphery predominantly in patients of higher age. Usually temporal periphery is affected. The finding is bilateral in approximately  30 %. Read More

World Neurosurg 2020 Jan 30;133:e129-e134. Epub 2019 Aug 30.

Department of Neurosurgery, Brain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Choroidal hemangioma (CH) is a benign vascular tumor that induces subretinal fluid collection or exudative retinal detachment and consequent visual symptoms. Current standard treatments for CH include cryotherapy, diathermy, photocoagulation, photodynamic therapy, transpupillary thermotherapy, and radiation therapy. Stereotactic radiosurgery has recently been applied to the treatment of CH because of its characteristic stiff dose-fall-off and accuracy. Read More

Photodiagnosis Photodyn Ther 2019 Dec 24;28:318-323. Epub 2019 Aug 24.

University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.

Purpose: To investigate the functional and anatomical results of autologous retinal pigment epithelial(RPE) cells and choroidal translocation after removal of the subfoveal choroidal neovascular membrane(CNVM) in patients with exudative age-related macular degeneration(AMD). To monitor the viability of choroidal patch with indocyanine green angiography(ICGA) and fundus autofluorescence(FAF) METHODS: This study was conducted as a retrospective, interventional case series, and evaluation of 8 patients ;4 patients had large (> 1 disk diameter) subfoveal choroidal membranes, 3 with massive subretinal hemorrhage and 1 case with suprachoroidal hemorrhage(SCH) + rhegmatogenous retinal detachment(RRD). After removal of the CNVM, the autologous full-thickness patch of the RPE, bruch's membrane, choriocapillaris, and choroid was excised from the midperiphery and placed under the macula. Read More