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J Taibah Univ Med Sci 2022 Apr 27;17(2):332-339. Epub 2021 Nov 27.

Department of Ophthalmology and Visual Sciences, School of Medical Sciences, Universiti Sains Malaysia, Malaysia.

This case-series aims to report three cases of endogenous endophthalmitis due to invasive syndrome.

Case 1: A 34-year-old lady who was admitted for pneumonia developed painful blurring of vision and redness in the right eye (RE) for one week. An examination of the RE revealed visual acuity (VA) of light perception (PL) with positive relative afferent pupillary defect (RAPD), proptosis, and restriction of extraocular movement with hypopyon. Read More

Am J Ophthalmol Case Rep 2022 Jun 5;26:101573. Epub 2022 May 5.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.

Purpose: To describe a case of sclerouveitis with exudative retinal detachment in a patient with chronic myelomonocytic leukemia.

Observations: An 82-year-old woman with chronic myelomonocytic leukemia (CMML) presented with acute painful right eye redness and decreased visual acuity. Examination revealed right eye anterior and posterior scleritis with exudative retinal detachment, as well as 2+ anterior chamber cell in the right eye and 0. Read More

Front Med (Lausanne) 2022 29;9:850129. Epub 2022 Apr 29.

Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: To report a modified technique of dry-lensectomy assisted lensectomy in the management of end-stage familial exudative vitreoretinopathy (FEVR) complicated with capsule-endothelial, iris-endothelial adhesion and secondary glaucoma.

Methods: 24 eyes of 16 patients with severe complications of advanced pediatric total retinal detachment caused by FEVR who received limbus-based dry-lensectomy were studied retrospectively. Preoperative and postoperative clinical information was collected and reviewed. Read More

Eur J Ophthalmol 2022 May 16:11206721221100627. Epub 2022 May 16.

Department of Ophthalmology, 63990Ankara University Faculty of Medicine, Ankara, Turkey.

Purpose: To investigate the distribution of pseudoretinoblastoma (PSRB) cases based on gender, age, and laterality.

Materials And Methods: The clinical records of 607 patients (851 eyes) who were referred for diagnosis of retinoblastoma or simulating conditions between October 1998 and May 2021 were retrospectively evaluated. Patients were stratified by age as follows: ≤1 year, >1-3 years, >3-5 years, and >5 years. Read More

BMC Ophthalmol 2022 May 6;22(1):205. Epub 2022 May 6.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

Background: To report the multimodal imaging and treatment of fifteen retinal capillary hemangioblastomas (RCHs) associated with Von Hippel-Lindau syndrome in a monocular patient during a long-term following-up, which supply high-resolution exquisite SS-OCTA images (VG200; SVision Imaging, Ltd., Luoyang, China) and management experience about multiple RCHs.

Case Presentation: A 34-year-old monocular male patient complained decreased visual acuity (20/100) without pain and redness in the left eye five years ago. Read More

Ann Palliat Med 2022 Apr;11(4):1589-1594

Department of Ophthalmology, Shengli Oilfield Central Hospital, Dongying, China.

Background: A case of Vogt-Koyanagi-Harada syndrome (VKH) first diagnosed with encephalitis was reported and it bring us the clinical reflection.

Case Description: A 73-year-old Chinese woman was first diagnosed in the department of neurology with headache, nausea, vomiting, and elevated body temperature. Cerebrospinal fluid (CSF) assays showed significant increases in leukocytes and Cerebrospinal fluid total protein (CS-TP). Read More

Arch Soc Esp Oftalmol (Engl Ed) 2022 Apr 20;97(4):234-238. Epub 2021 Nov 20.

Servicio de Oftalmología, Hospital General Obispo Polanco, Teruel, Spain.

A 53-year-old male with no systemic disorders, other than controlled arterial hypertension, presented with asymptomatic, bilateral neurosensory retinal detachment (NRD) detected during a routine revision. The patient reported the use of tadalafil (a phosphodiesterase-5 inhibitor [PDE5I]) for erectile dysfunction. Following suspension of the drug, subretinal fluid reabsorption was confirmed, with the persistence of chronic alterations in the optical coherence tomography (OCT) and the visual field. Read More

Korean J Parasitol 2022 Apr 20;60(2):133-137. Epub 2022 Apr 20.

Department of Ophthalmology, The First Affiliated Hospital of Guangxi Medical University, Nanning 513200, Guangxi Zhuang Autonomous Region, China.

Toxocariasis is one of the most common geohelminth infections in several parts of the world. We describe a rare case of ocular toxocariasis with secondary exudative retinal detachment treated with albendazole and an intravitreal dexamethasone implant. A 13-year-old boy with counting finger vision was diagnosed with retinal vasculitis and exudative retinal detachment in his right eye. Read More

Turk J Ophthalmol 2022 04;52(2):147-152

Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey

The aim of this case report is to describe a case of atypical central serous chorioretinopathy (CSCR) definitively diagnosed after 8 years. A 44-year-old woman presented with reduced visual acuity in her left eye. Her visual acuity was light perception with projection in the right eye and 0. Read More

Am J Ophthalmol Case Rep 2022 Jun 12;26:101518. Epub 2022 Apr 12.

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Purpose: To report a case with unusual initial manifestation of uveal melanoma in a 46-year-old adult.

Observations: A 46-year-old man demonstrated a mid-peripheral temporal partially hyperpigmented lesion in his left eye. Initial clinical appearance as well as multimodal imaging approaches were similar to a chorioretinitic disease. Read More

Ocul Immunol Inflamm 2022 Apr 20. Epub 2022 Apr 20.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

The fundus photographs provided show deep yellowish lesions, multifocal exudative retinal detachments, and optic disc hyperemia in both eyes. Spectral domain optical coherence tomography scans shown demonstrate bilateral exudative retinal detachments involving the macula in the right eye. The exudative retinal detachment is characterized by the presence of subretinal fibrin and septa. Read More

Ophthalmic Surg Lasers Imaging Retina 2022 04 1;53(4):222-226. Epub 2022 Apr 1.

A 47-year-old woman consulted Fundación de Cirugía Ocular Jorge Zambrano for a 45-day bilateral vision decrease. Fundus examination revealed retinal edema, peripapillary cotton wool exudates, nerve fiber layer hemorrhages, Elschnig's spots, and peripheral exudative retinal detachment in both eyes. These findings were suspected to be a complication from gemcitabine, a chemotherapeutic agent that she had taken for endometrial cancer, which was discontinued owing to thrombocytopenia. Read More

Ophthalmic Surg Lasers Imaging Retina 2022 04 1;53(4):228-232. Epub 2022 Apr 1.

Familial exudative vitreoretinopathy (FEVR) is a rare hereditary vitreoretinopathy resulting from mutations in the signaling pathway leading to abnormalities in fetal retinal vasculogenesis, angiogenesis, and retinal vascular maintenance. Severe FEVR may result in congenital retinal detachment resembling Norrie disease. The authors report the first case of planned preterm delivery and treatment of a patient with severe FEVR from biallelic mutations whose siblings had congenital tractional retinal detachments with light perception vision outcomes after conventional care. Read More

Invest Ophthalmol Vis Sci 2022 04;63(4)

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: The purpose of this study was to establish a genotype-phenotype correlation of familial exudative vitreoretinopathy (FEVR) caused by FZD4 gene mutations.

Methods: Six hundred fifty-one probands and their family members were recruited based on a clinical diagnosis of FEVR between 2015 and 2021 at Zhongshan Ophthalmic Center. Ocular examinations were performed in all participants. Read More

Ophthalmic Genet 2022 Apr 6:1-9. Epub 2022 Apr 6.

Ophthalmology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Knobloch syndrome results from recessive mutations in COL18A1 and is characterized by retinopathy and occipital scalp, brain and skull defects.

Methods And Materials: We report three siblings, born to consanguineous parents, two of whom with genetically confirmed Knobloch syndrome due to a homozygous pathogenic variant c.4054_4055del; p. Read More

Int Med Case Rep J 2022 21;15:111-115. Epub 2022 Mar 21.

Department of Ophthalmology, Saitama Medical University Faculty of Medicine, Saitama, Japan.

Although intraocular lymphoma (IOL) mainly has have vitreous opacity and subretinal infiltration, its clinical symptoms are diverse. We report a case of IOL that mainly showed exudative retinal detachment in which analysis of IgH gene rearrangement (AIGHR) of the collected subretinal fluid sample was useful for diagnosis. A 77-year-old woman developed decreased left visual acuity for 1 month. Read More

BMC Infect Dis 2022 Mar 18;22(1):265. Epub 2022 Mar 18.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, No. 5, Fuxing St., Gueishan Dist., Taoyuan City, 333, Taiwan.

Background: Postvitrectomy endophthalmitis is a rare and serious complication following vitreoretinal surgeries. Morganella morganii, an emerging gram-negative, facultative anaerobic rod, is related to severe nosocomial infections in various organs and thus has gained importance in recent decades. Morganella morganii infection following intraocular surgery is rarely reported. Read More

GMS Ophthalmol Cases 2022 8;12:Doc01. Epub 2022 Feb 8.

Department of Uvea, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India.

We herein report a case of a young female presenting with multiple nodular scleral abscesses mimicking infective scleritis with exudative retinal detachment. Repeated diagnostic scraping for microbiological and histopathological analysis was inconclusive. The patient's systemic and collagen disease work-up was non-contributory. Read More

Am J Ophthalmol Case Rep 2022 Mar 3;25:101305. Epub 2022 Feb 3.

Stein Eye Institute, Department of Ophthalmology, UCLA, USA.

Purpose: We report the first known case of eye findings associated with a Fas-associated protein with death domain (FADD) gene mutation, an exceedingly rare entity.

Observations: A 7-year-old boy was referred for decreased vision and eye examination revealed cystoid macular edema and peripheral retinal ischemia in both eyes and progression to tractional retinal detachment in the right eye.

Conclusions And Importance: This case suggests that baseline and annual ophthalmic screening may be beneficial in individuals with FADD mutations. Read More

Cureus 2022 Feb 15;14(2):e22256. Epub 2022 Feb 15.

Ophthalmology, Imam Abdulrahman Bin Faisal University, Dammam, SAU.

The aim of this study is to share our experience of a baby boy patient who presented with rare endogenous endophthalmitis that ended up with exudative retinal detachment; emphasizing the clinical presentation, follow-ups progression, and the management plan. A case report of a one-month-old preterm baby boy presented with eye discharge in his left eye (OS) associated with eyelid swelling and chemosis for four days. His clinical examination revealed a congested left eye with proptosis, absent red reflex, and normal intraocular pressure (IOP) while a portable slit-lamp examination showed an edematous left eye with cloudy cornea but no infiltrates and no view to the posterior segment. Read More

Indian J Ophthalmol 2022 Mar;70(3):1074

Vitreoretina Service, Disha Eye Hospitals; Occuloplasty and Comprehensive Ophthalmology, Disha Eye Hospitals, Barrackpore, Kolkata, West Bengal, India.

Background: Falciform folds are congenital tractional retinal folds due to strong contractile forces and hyperextensibility of retina resulting in temporal dragging of the macula and often associated with familial exudative vitreoretinopathy and retinal detachment (RD). Retinologists are reluctant to treat these entities in view of their poor visual recovery.

Purpose: To describe a novel surgical technique to unfold the falciform folds. Read More

Sci Rep 2022 02 24;12(1):3167. Epub 2022 Feb 24.

Kim's Eye Hospital, Konyang University College of Medicine, 156, 4ga, Yeongdeungpo-dong, Yeongdeungpo-gu, Seoul, South Korea.

We investigated the characteristics of neovascular age-related macular degeneration (AMD) in which exudation predominantly occurs as a subretinal fluid (SRF) during anti-vascular endothelial growth factor (VEGF) treatment. A total of 509 treatment-naïve neovascular AMD patients treated with anti-VEGF for 24 months were retrospectively analyzed. The baseline characteristics to determine the odds of occurrence of SRF alone were evaluated using multivariate modeling. Read More

Ocul Immunol Inflamm 2022 Feb 24:1-8. Epub 2022 Feb 24.

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

Purpose: To report a bilateral diffuse uveal melanocytic proliferation (BDUMP) patient whose initial presentation was glaucoma.

Methods: Clinical review of a BDUMP case.

Results: A 65-year-old woman presented with ocular pain of the left eye for 1 day and vision loss of the right eye for 1 week. Read More

Turk J Ophthalmol 2022 02;52(1):37-44

Gazi University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey

Objectives: To report visual and anatomical outcomes following two- or four-quadrant partial-thickness sclerectomy and sclerotomy surgery to treat nanophthalmos (NO)-related uveal effusion (UE).

Materials And Methods: Consecutive patients with NO-related UE were treated with four-quadrant or two-quadrant (for those with associated glaucoma) partial-thickness sclerectomy and sclerotomy surgery. Axial length, extent of UE, preoperative, postoperative, and final best corrected visual acuity (BCVA), time to retinal reattachment, and rates of retinal reattachment and recurrence were noted. Read More

Int J Ophthalmol 2022 18;15(2):276-283. Epub 2022 Feb 18.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara 06590, Turkey.

Aim: To evaluate the results and complications of secondary endoresection pars plana vitrectomy for choroidal melanoma and review the previously reported endoresection studies on the treatment of choroidal melanoma.

Methods: The medical records of 6 patients with choroidal melanoma who underwent secondary endoresection between March 2012 and March 2020 were retrospectively reviewed. The indications for secondary endoresection were progressive or recurrent tumor and severe exudative retinal detachment after previous treatment with plaque radiotherapy/Cyberknife radiosurgery/transpupillary thermotherapy (TTT). Read More

Rev Esp Anestesiol Reanim (Engl Ed) 2022 02 15;69(2):114-118. Epub 2022 Feb 15.

Servicio de Anestesiología y Reanimación, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain.

Exudative retinal detachment (ERD) is a rare complication that occurring in 1% of patients with preeclampsia, its incidence is increased when it is associated with HELLP syndrome. Preeclampsia is defined by the development of arterial hypertension and proteinuira occurs after 20 weeks of gestation until postpartum. HELLP syndrome (low platelets, hemolysis and elevated liver enzymes) is a severe form of preeclampsia. Read More

Cytopathology 2022 May 24;33(3):402-405. Epub 2022 Feb 24.

Vitreo-Retina Services, Advanced Eye Centre, Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Coats disease is an exudative retinal vasculopathy characterised by presence of yellow-golden deposits in the retina and retinal detachment. Subretinal fluid drainage performed as a part of therapeutic management makes the fluid amenable to cytological examination. Infection by Toxoplasma may closely simulate the ocular symptoms seen in Coats disease. Read More

Ophthalmic Surg Lasers Imaging Retina 2022 02 1;53(2):113-115. Epub 2022 Feb 1.

Chimeric antigen receptor (CAR) T-cell therapy has become a novel approach in the treatment of many hematologic malignancies. However, ocular adverse effects have not been well described. This report presents a case of a pediatric patient with relapsed B-cell acute lymphoblastic leukemia with ocular involvement treated with CAR T-cell therapy who developed an exudative retinal detachment likely secondary to an inflammatory response to CAR T-cell therapy. Read More

Ann Med Surg (Lond) 2022 Feb 25;74:103292. Epub 2022 Jan 25.

Professor and Head of Pediatric Ophthalmology Department, Hopital 20 Aout, 1953, Casablanca, Morocco.

Introduction: Von Hippel-Lindau disease (VHL), also known as Von Hippel-Lindau syndrome, is a rare genetic disorder with multisystem involvement. It is characterised by the development of multiple vascularised tumours, particularly cerebellar, retinal and/or visceral. The disease can occur at any age and usually starts with retinal hemangioblastomas. Read More

BMJ Case Rep 2022 Feb 9;15(2). Epub 2022 Feb 9.

Department of Neurology, G S Neuroscience Clinic and Research Center, Patna, Bihar, India.

A male in his early teens presented with redness of the right eye following a fall. This redness was progressive and increased suddenly over the week prior to presentation. Fundus evaluation revealed an exudative retinal detachment, and a bruit was audible over the right eye. Read More