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Ophthalmology 2022 May 17. Epub 2022 May 17.

Eye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Purpose: To assess the time course of secondary visual axis opacification (VAO) that led to additional surgery after primary intraocular lens (IOL) implantation in children and to describe further surgical outcomes. Comparison of different lens types.

Design: Single center, retrospective analysis of children aged 1-14 years who underwent cataract surgery with primary IOL implantation. Read More

Retina 2022 May 12. Epub 2022 May 12.

Department of Ophthalmology, Balıkesir University Medicine Faculty, Balıkesir, TURKEY.

Purpose: To evaluate the effect of internal limiting membrane (ILM) peeling on anatomical and functional results in pars plana vitrectomy (PPV) performed eyes with tractional retinal detachment affecting the macula due to diabetes mellitus (DM).

Methods: Patients without ILM peeling were considered as Group 1, and with ILM peeling were considered as Group 2. The main outcomes were the best-corrected visual acuity (BCVA) at 6 months, and the rate of epiretinal membrane (ERM) formation within 6 months. Read More

PLoS One 2022 20;17(5):e0268377. Epub 2022 May 20.

Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Purpose: An increasing number of posterior segment disorders is routinely managed with pars plana vitrectomy (PPV). In older, phakic patients cataract formation is expected within the first two years after surgery. For younger patients its progression is individually fluctuating. Read More

Retina 2022 Jun;42(6):1103-1110

Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Purpose: The purpose of this study was to evaluate the prognostic utility of the degree of vitreous attachment for predicting outcomes of vitrectomy for nonclearing vitreous hemorrhage associated with proliferative diabetic retinopathy.

Methods: Medical records of patients who underwent primary vitrectomy for dense nonclearing vitreous hemorrhage secondary to proliferative diabetic retinopathy were examined retrospectively. Eyes were divided into four groups based on the intraoperatively assessed stage of posterior vitreous detachment (PVD), ranging from Stage 0/1 (complete or near-complete vitreoretinal adhesion) to Stage 4 (complete PVD). Read More

J Taibah Univ Med Sci 2022 Apr 27;17(2):332-339. Epub 2021 Nov 27.

Department of Ophthalmology and Visual Sciences, School of Medical Sciences, Universiti Sains Malaysia, Malaysia.

This case-series aims to report three cases of endogenous endophthalmitis due to invasive syndrome.

Case 1: A 34-year-old lady who was admitted for pneumonia developed painful blurring of vision and redness in the right eye (RE) for one week. An examination of the RE revealed visual acuity (VA) of light perception (PL) with positive relative afferent pupillary defect (RAPD), proptosis, and restriction of extraocular movement with hypopyon. Read More

Nat Commun 2022 May 19;13(1):2796. Epub 2022 May 19.

Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-proliferation of retinal pigment epithelial (RPE) cells. Current treatment relies primarily on surgical removal of these membranes. Read More

Ophthalmol Retina 2022 May 16. Epub 2022 May 16.

California Retina Consultants, Santa Barbara, California.

Purpose: To provide strategies for the management of key ocular adverse events (AEs) that may be encountered with the Port Delivery System with ranibizumab (PDS) in practice, and to provide recommendations that may mitigate such AEs based on clinical trial experience and considerations from experts in the field.

Design: Safety evaluation based on the phase 2 Ladder (NCT02510794) and phase 3 Archway (NCT03677934) trials of the PDS.

Methods: The PDS is a permanent, indwelling, and refillable ocular drug delivery system that requires standardized procedural steps, for its insertion and refill-exchange procedures, which have evolved during the PDS clinical program. Read More

Ophthalmol Retina 2022 May 16. Epub 2022 May 16.

The University of Sydney, Sydney Medical School, Discipline of Ophthalmology, Save Sight Institute, New South Wales, Australia.

Purpose: To report the estimated incidence, probability, risk factors and one-year outcomes of rhegmatogenous retinal detachment (RRD) in eyes receiving intravitreal injections (IVT) of vascular endothelial growth factor (VEGF) inhibitors for various retinal conditions in routine clinical practice.

Design: Retrospective analysis of data from a prospectively designed observational outcomes registry: the Fight Retinal Blindness!

Project:

Participants: Eyes starting IVT with VEGF inhibitors (ranibizumab, aflibercept or bevacizumab) for neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME) or retinal vein occlusion (RVO) from 1 January 2006 to 31 December 2020. All eyes that developed RRD within 90 days of an intravitreal injection were defined as RRD cases and were matched with control eyes. Read More

Vet Pathol 2022 May 19:3009858221098431. Epub 2022 May 19.

Cytopath Ltd, Ledbury, UK.

Ocular mycobacterial infections are an under-recognized cause of morbidity in the domestic cat. This study aimed to explore the distribution, histopathological appearance, and severity of feline ocular mycobacterial lesions, and to characterize the immune cell population with immunohistochemistry. Routine histological staining with hematoxylin and eosin, and Masson's trichrome, was performed to identify ocular lesions and assign an inflammation score based on the number of cells present. Read More

Am J Ophthalmol Case Rep 2022 Jun 5;26:101573. Epub 2022 May 5.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.

Purpose: To describe a case of sclerouveitis with exudative retinal detachment in a patient with chronic myelomonocytic leukemia.

Observations: An 82-year-old woman with chronic myelomonocytic leukemia (CMML) presented with acute painful right eye redness and decreased visual acuity. Examination revealed right eye anterior and posterior scleritis with exudative retinal detachment, as well as 2+ anterior chamber cell in the right eye and 0. Read More

J Glaucoma 2022 May 10. Epub 2022 May 10.

Ophthalmology department, Mohamed Taher Maamouri hospital, Faculty of Medicine Tunis El Manar, Tunisia.

Purpose: To assess the efficiency and safety of MicroPulse® Transscleral Laser Therapy (TLT) in the management of silicone oil-induced glaucoma.

Methods: A prospective case series of 33 eyes with uncontrolled silicone oil-induced glaucoma was enrolled at the department of ophthalmology of Mohamed Taher Maamouri Hospital, Nabeul, Tunisia. Patients were treated with MicroPulse TLT using the IRIDEX Cyclo G6® Glaucoma Laser System with the MicroPulse P3® fiberoptic handheld probe. Read More

Eur J Ophthalmol 2022 May 17:11206721221102258. Epub 2022 May 17.

Department of Vitreo-retinal Services, 29954Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

Aim: To report the outcomes of the "inverse drainage Nd:YAG laser membranotomy" technique for the management of pre-macular hemorrhage (PMH), which has its inferior margin near the fovea.

Methods: This retrospective study included eyes with PMH, with its inferior margin located within 0.5 disc-diameter (DD) of the fovea. Read More

Hum Genome Var 2022 May 17;9(1):16. Epub 2022 May 17.

Division of Medical Genetics, Kanagawa Children's Medical Center, Yokohama, Japan.

Spondyloepiphyseal dysplasia congenita (SEDC) is a multisystemic skeletal disorder caused by pathogenic variants in COL2A1. Here, we report the genotype-phenotype correlations in five Japanese patients with SEDC based on their clinical and radiological findings. All five patients had novel missense variants resulting in glycine substitutions (G474V, G543E, G567S, G594R, and G1170R). Read More

Lasers Med Sci 2022 May 17. Epub 2022 May 17.

Eye Hospital, University Medical Centre Ljubljana, 1000, Ljubljana, Slovenia.

Purpose: The purpose of this prospective study was to predict the effectiveness of subthreshold micropulse laser (SML) based on morphological parameters in patients with central serous chorioretinopathy (CSC).

Methods: Thirty-one patients were examined at presentation, 3 months, and 6 months after the disease onset. In patients with persistent subretinal fluid (SRF) at 3 months, SML was performed. Read More

Sci Rep 2022 May 16;12(1):8076. Epub 2022 May 16.

Department of Ophthalmology, Hangil Eye Hospital, 35 Bupyeong-daero, Bupyeong-gu, Incheon, 21388, South Korea.

We investigated the combined effect of silicone tamponade and the internal limiting membrane (ILM) peeling and investigated whether timing of peeling of the ILM affects the outcomes of vitrectomy with silicone oil tamponade in eyes with proliferative diabetic retinopathy (PDR). Here, we examined 63 eyes (58 patients) with PDR, which underwent vitrectomy with silicone oil tamponade and stepwise removal of silicone oil. ILM peeling was performed just before oil injection (group 1; 33 eyes, 30 patients) or after oil removal (group 2; 30 eyes, 28 patients). Read More

J Fr Ophtalmol 2022 May 13. Epub 2022 May 13.

Department of Ophthalmology Shaare-Zedek Medical Center Affiliated with the Hebrew University, Hadassah School of Medicine, Jerusalem, Israel.

Background And Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has accelerated vaccine development. The BNT162b2 messenger RNA (mRNA) vaccine is being administered worldwide. The purpose of this case series is to report a possible association between the BNT162b2 mRNA vaccine and Central serous chorioretinopathy (CSC). Read More

Curr Eye Res 2022 May 16:1-7. Epub 2022 May 16.

Regional Ophthalmological Center, Volyn Regional Clinical Hospital, Lutsk, Ukraine.

Purpose: To construct a realistic physical model of viscoelastic retinal stretching and, on its basis, derive a universal quantitative criterion of irreversible retinal deformations during age-related macular degeneration.

Methods: In this work, standard methods of nonlinear fracture mechanics of ductile and viscoelastic materials were applied to study the evolution of retinal deformation progress in patients with neovascular age-related macular degeneration in the area of large druses or subretinal or sub-retinal pigment epithelium fluid accumulation. A two-dimensional rhombic model of viscoelastic Kelvin-Feucht primitives was used to reconstruct the parameters included in the approximation of the creep strain growth rate. Read More

Retina 2022 May 6. Epub 2022 May 6.

Joint Shantou International Eye Center (JSIEC) of Shantou University & the Chinese University of Hong Kong, Shantou, China.

Background: Retinal detachment (RD) is a severe complication of acute retinal necrosis (ARN), threatening vision. The published articles on the effectiveness of laser in preventing RD in ARN are controversial.

Objectives: To evaluate whether prophylactic laser is effective for RD following ARN. Read More

Retina 2022 May 6. Epub 2022 May 6.

Disha Eye Hospitals Pvt Ltd, 88(63A) Ghosh Para Road, Barrackpore, Kolkata - 700120, West Bengal, India.

Purpose: To describe a novel surgical technique to unfold congenital falciform folds.

Method: A retrospective, interventional case series was performed where a novel technique was applied to treat 5 cases of congenital falciform folds. 25 gauge vitrectomy was performed along with the removal of all vitreous adhesions. Read More

J Am Anim Hosp Assoc 2022 May;58(3):121-128

From MedVet, Columbus, Ohio (T.W.).

The objective of this study was to determine the complication risk and prevalence after phacoemulsification in cats with presumed congenital/inherited cataracts. Twelve client-owned cats were included in the study. This retrospective study spanned 13 yr and involved 22 eyes. Read More

Ophthalmic Surg Lasers Imaging Retina 2022 05 1;53(5):293-296. Epub 2022 May 1.

Homozygous protein C deficiency is a rare hypercoagulability disorder. This study describes the ocular manifestations and the genetic background in a family with two affected children. This is a retrospective review of ophthalmic examinations, investigations, genetic testing, and blood work-up of two children with homozygous protein C deficiency from a single family. Read More

Ophthalmic Surg Lasers Imaging Retina 2022 05 1;53(5):285-292. Epub 2022 May 1.

Objective: To analyze the rate and timing of retinal redetachments and other complications following pars plana vitrectomy for retinal detachment repair with silicone oil tamponade and the effect of face-down positioning duration on these endpoints.

Materials And Methods: A retrospective study was performed on patients with retinal detachment repair via pars plana vitrectomy with silicone oil tamponade between 2015 and 2020. Surgery was performed by 10 physicians associated with a private retina practice in Cleveland, Ohio. Read More

Front Med (Lausanne) 2022 29;9:850129. Epub 2022 Apr 29.

Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: To report a modified technique of dry-lensectomy assisted lensectomy in the management of end-stage familial exudative vitreoretinopathy (FEVR) complicated with capsule-endothelial, iris-endothelial adhesion and secondary glaucoma.

Methods: 24 eyes of 16 patients with severe complications of advanced pediatric total retinal detachment caused by FEVR who received limbus-based dry-lensectomy were studied retrospectively. Preoperative and postoperative clinical information was collected and reviewed. Read More

Eur J Ophthalmol 2022 May 16:11206721221100627. Epub 2022 May 16.

Department of Ophthalmology, 63990Ankara University Faculty of Medicine, Ankara, Turkey.

Purpose: To investigate the distribution of pseudoretinoblastoma (PSRB) cases based on gender, age, and laterality.

Materials And Methods: The clinical records of 607 patients (851 eyes) who were referred for diagnosis of retinoblastoma or simulating conditions between October 1998 and May 2021 were retrospectively evaluated. Patients were stratified by age as follows: ≤1 year, >1-3 years, >3-5 years, and >5 years. Read More

Int Ophthalmol 2022 May 16. Epub 2022 May 16.

Beyoglu Eye Training and Research Hospital, University of Health Sciences, Bereketzade Cami Street Number:2, Beyoglu, Istanbul, Turkey.

Purpose: To evaluate the characteristics and analyze the results of patients who underwent pars plana vitrectomy (PPV) as the first surgery due to rhegmatogenous retinal detachment (RRD) in pediatric age.

Methods: The records of pediatric patients who underwent PPV alone due to RRD were reviewed retrospectively. The best corrected visual acuity (BCVA) values were recorded before and after the surgery. Read More

Eye (Lond) 2022 May 13. Epub 2022 May 13.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Background/objectives: To study the development, evolution, outcomes, and prognostic factors of lamellar macular hole (LMH) in highly myopic (HM) patients.

Methods: Fifty eyes from 47 HM patients with LMHs were retrospectively enrolled. Relevant pre- and post-LMH optical coherence tomography findings and visual acuity were collected. Read More

Sci Rep 2022 May 12;12(1):7916. Epub 2022 May 12.

Aier Eye Hospital of Wuhan University, No.481 Zhongshan Road, Wuchang District, Wuhan, China.

To detect the prognostic factors associated with initial reattachment after primary pars plana vitrectomy (PPV) with air tamponade for rhegmatogenous retinal detachment (RRD). We retrospectively reviewed 92 eyes of 92 patients with RRD. All eyes underwent PPV with air tamponade and a follow-up of at least 6 months. Read More

BMC Ophthalmol 2022 May 12;22(1):214. Epub 2022 May 12.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.

Background: We evaluated the effect of vitrectomy with internal limiting membrane (ILM) peeling and gas tamponade for myopic foveoschisis (MF), and analysed prognosis with different gas tamponade.

Methods: Retrospective, non-randomized study. The records of patients with MF treated by vitrectomy, were reviewed. Read More