28,041 results match your criteria Retinal Detachment


Loss of High-Mobility Group Box 1 (HMGB1) Protein in Rods Accelerates Rod Photoreceptor Degeneration After Retinal Detachment.

Invest Ophthalmol Vis Sci 2020 May;61(5):50

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Purpose: Retinal detachment (RD) disrupts the nutritional support and oxygen delivery to photoreceptors (PRs), ultimately causing cell death. High-mobility group box 1 (HMGB1) can serve as an extracellular alarmin when released from stressed cells. PRs release HMGB1 after RD. Read More

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http://dx.doi.org/10.1167/iovs.61.5.50DOI Listing

IDIOPATHIC PENETRATION OF CILIA INTO THE POSTERIOR SEGMENT PRESENTING AS SECTORAL SCLERITIS WITH PROGRESSIVE INTRAOCULAR INFLAMMATION.

Retin Cases Brief Rep 2020 May 25. Epub 2020 May 25.

Department of Ophthalmology, University of Washington, Seattle, Washington.

Purpose: To report two cases of idiopathic intraocular cilia presenting as sectoral scleritis with progressive intraocular inflammation.

Methods: Both patients were treated with intravitreal antibiotics and underwent pars plana vitrectomy where the cilia were removed and identified on histopathology.

Results: One patient developed a retinal detachment while being treated for presumed endophthalmitis. Read More

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http://dx.doi.org/10.1097/ICB.0000000000001006DOI Listing

Cystoid macular oedema following pars plana vitrectomy for macula on rhegmatogenous retinal detachment.

Clin Exp Optom 2020 May 26. Epub 2020 May 26.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1111/cxo.13097DOI Listing

Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age-related macular degeneration.

Clin Exp Ophthalmol 2020 May 26. Epub 2020 May 26.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Importance: The clinical implications of different morphologies of choroidal neovascularization (CNV), as evaluated by optical coherence tomography angiography (OCTA) in neovascular age-related macular degeneration (nAMD), are lacking.

Background: To describe the morphology of CNV in nAMD using OCTA, and to compare the visual prognosis and other structural OCT biomarkers between different morphologic patterns.

Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1111/ceo.13797DOI Listing

Preoperative, Intraoperative and Postoperative Corticosteroid Use as an Adjunctive Treatment for Rhegmatogenous Retinal Detachment.

J Clin Med 2020 May 21;9(5). Epub 2020 May 21.

Department of Ophthalmology, University of Catania, 95100 Catania, Italy.

The treatment for rhegmatogenous retinal detachment (RRD) is surgery, including pars plana vitrectomy (PPV) and scleral buckling (SB). Despite surgical advances, degeneration of the photoreceptors and post-operative complications, such as proliferative vitreoretinopathy (PVR), often occurs as the result of inflammation, preventing complete visual recovery or causing RRD recurrence. There is increasing evidence that in the presence of RRD, the activation of inflammatory processes occurs and the surgery itself induces an inflammatory response. Read More

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http://dx.doi.org/10.3390/jcm9051556DOI Listing

Preoperative Steroid Use in Rhegmatogenous Retinal Detachment Associated with Choroidal Detachment after 23-Gauge Vitrectomy.

J Ophthalmol 2020 2;2020:6707239. Epub 2020 May 2.

Retinal & Vitreous Diseases Department of Wuhan Aier Eye Hospital, Aier Ophthalmic College of Central-South University, Wuhan 430064, China.

Background: Rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) is rare and the prognosis is poor. This retrospective study evaluated the effect of preoperative steroid on the clinical outcome of patients with RRDCD receiving 23-gauge pars plana vitrectomy (PPV).

Methods: Sixty-six patients (67 eyes) with diagnosed RRDCD underwent 23-gauge PPV. Read More

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http://dx.doi.org/10.1155/2020/6707239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222551PMC

Multimodal Imaging Features of Bilateral Choroidal Ganglioneuroma.

J Ophthalmol 2020 11;2020:6231269. Epub 2020 May 11.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: Bilateral choroidal ganglioneuroma is extremely rare, and no cases have been described in the literature. Multimodal images are crucial for its diagnosis. Here, we evaluated multimodal images in the early stage of choroidal ganglioneuroma. Read More

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http://dx.doi.org/10.1155/2020/6231269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240787PMC

Treatment effect of posterior scleral reinforcement on controlling myopia progression: A systematic review and meta-analysis.

PLoS One 2020 26;15(5):e0233564. Epub 2020 May 26.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: High myopia is a sight-threatening disease that causes axial length elongation and severe complications. Data on the benefits of posterior scleral reinforcement surgery in myopia control have been conflicting. The purpose of this study was to explore the treatment effect and complications of posterior scleral reinforcement in the treatment of myopia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233564PLOS

"All-Nasal" Approach for 25-Gauge Lens Sparing Vitrectomy in Stage 4B Retinopathy of Prematurity.

Retina 2020 May 20. Epub 2020 May 20.

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To describe a novel "all-nasal" approach for lens sparing vitrectomy in stage 4B retinopathy of prematurity.

Methods: This is a pilot study in infants with Stage 4B retinopathy of prematurity. Eyes included had tractional retinal detachment approaching the retrolental space temporally. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002849DOI Listing

PERFLUOROCARBON LIQUID-ASSISTED INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE VERSUS INTERNAL LIMITING MEMBRANE PEELING FOR HIGHLY MYOPIC MACULAR HOLE RETINAL DETACHMENT.

Retina 2020 May 18. Epub 2020 May 18.

Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.

Purpose: To compare the efficacy of a modified perfluorocarbon liquid-assisted inverted internal limiting membrane (ILM) flap technique with the standard ILM peeling for the treatment of macular hole retinal detachment in highly myopic eyes.

Methods: This was a retrospective, consecutive, nonrandomized comparative study. Forty-two macular hole retinal detachment eyes of 42 patients were included into either a perfluorocarbon liquid-assisted inverted ILM flap technique group (n = 22, inverted group) or standard ILM removal group (n = 20, peeling group). Read More

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http://dx.doi.org/10.1097/IAE.0000000000002853DOI Listing

Long-term outcomes of pediatric traumatic cataracts and retinal detachments due to self-inflicted injuries.

Eur J Ophthalmol 2020 May 26:1120672120926452. Epub 2020 May 26.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.

Purpose: To report the characteristics and longitudinal visual outcomes of traumatic cataracts and retinal detachments in children with self-inflicted injury.

Methods: A retrospective case series of pediatric patients at a tertiary care center who sustained ocular trauma due to self-inflicted injury between 2000 and 2014.

Results: A total of 11 children, all with an intellectual disability and a mean age of 10 ± 4. Read More

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http://dx.doi.org/10.1177/1120672120926452DOI Listing

Tomographic characteristics of focal choroidal excavation and its association with retinal disorders.

Eur J Ophthalmol 2020 May 26:1120672120927862. Epub 2020 May 26.

Ulucanlar Eye Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Purpose: To evaluate the morphological, clinical, and tomographic characteristics of focal choroidal excavation in the context of concomitant retinal pathologies.

Methods: This case series included 13 eyes of 13 patients with focal choroidal excavation diagnosed by spectral-domain optical coherence tomography. Morphologic characteristics of excavation and quantitative thicknesses of retinal layers and choroid were analyzed in excavation area, area adjacent to excavation, and fellow eye without focal choroidal excavation by spectral-domain optical coherence tomography. Read More

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http://dx.doi.org/10.1177/1120672120927862DOI Listing

[Preliminary clinical observations of the effect of posterior continuous curvilinear capsulorhexis with intraocular lens optic capture in the treatment of pediatric cataract].

Zhonghua Yan Ke Za Zhi 2020 May;56(5):343-348

Qingdao Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao 266071, China.

To observe the preliminary clinical effect of intraocular lens optic capture through posterior continuous curvilinear capsulorhexis in the treatment of pediatric cataract. It was a retrospective case series study. Forty-three eyes of 28 children underwent posterior continuous curvilinear capsulorhexis with posterior chamber intraocular lens optic capture to treat cataract from June 2017 to October 2018 in Qingdao Eye Hospital. Read More

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http://dx.doi.org/10.3760/cma.j.cn112142-20190628-00351DOI Listing

Inverted Internal Limiting Membrane Flap versus Internal Limiting Membrane Peeling for Macular Hole Retinal Detachment in High Myopia.

Ophthalmol Retina 2020 Apr 2. Epub 2020 Apr 2.

Department of Ophthalmology, Japanese Red Cross Otsu Hospital, Otsu, Japan.

Purpose: To compare surgical outcomes between the inverted internal limiting membrane (ILM) flap technique and ILM peeling for macular hole retinal detachment (MHRD) in eyes with high myopia.

Design: Multicenter cohort study.

Participants: We retrospectively reviewed medical records of consecutive patients treated between June 2008 and September 2018 at 7 hospitals and included 100 eyes with MHRD associated with high myopia in our study. Read More

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http://dx.doi.org/10.1016/j.oret.2020.03.021DOI Listing

Pathology features and the results of treatment of two cases of posterior choroidal leiomyoma.

BMC Ophthalmol 2020 May 24;20(1):198. Epub 2020 May 24.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Posterior choroidal leiomyoma is an extremely rare tumor, to our knowledge, less than 10 cases reported in the literature. The definite diagnosis can be confirmed by immunohistochemistry, and local resection is preferable to enucleation for the posterior choroidal leiomyoma.

Case Presentation: Two adult Asian women presented with progressive vision loss in their right eyes. Read More

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http://dx.doi.org/10.1186/s12886-020-01445-6DOI Listing

Characteristics of myopic traction maculopathy in myopic Singaporean adults.

Br J Ophthalmol 2020 May 23. Epub 2020 May 23.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore

Purpose: To investigate the characteristics, risk factors and visual impact of myopic traction maculopathy (MTM) among adults with myopia in Singapore.

Methods: We analysed 3316 myopic eyes of adults aged over 40 years who participated in the Singapore Epidemiology of Eye Diseases-2 study. Detailed questionnaires and ophthalmic examinations were conducted. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316182DOI Listing

A Comparison Study of Polypoidal Choroidal Vasculopathy Imaged with Indocyanine Green Angiography and Swept Source OCT Angiography.

Am J Ophthalmol 2020 May 20. Epub 2020 May 20.

Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, South Korea. Electronic address:

Purpose: Indocyanine green angiography (ICGA) was compared with swept source optical coherence tomography angiography (SS-OCTA) for the detection of polypoidal choroidal vasculopathy (PCV).

Design: Retrospective, cross-sectional.

Methods: Patients with treatment-naïve PCV based on ICGA imaging underwent same day SS-OCTA imaging at Kyung Hee University Medical Center between April 2017 to November 2018. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.05.017DOI Listing

Refractory adult Coats disease treated with dexamethasone intravitreal implant: A case report.

Medicine (Baltimore) 2020 May;99(20):e20249

Department of Ophthalmology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University.

Introduction: Coats disease is a sporadic, retinal vascular abnormality, causing blindness. Several interventional methods, including laser photocoagulation, have been proposed; however, the use of intravitreal dexamethasone in refractory Coats disease is not well described.

Patient Concerns: A 38-year-old man presented with a painless reduction in visual acuity in his right eye, commencing 15 days prior to initial assessment. Read More

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http://dx.doi.org/10.1097/MD.0000000000020249DOI Listing

Standard 6 mm Compared to Wide Field 16.5 mm Optical Coherence Tomography for Staging of Posterior Vitreous Detachment.

Ophthalmol Retina 2020 May 19. Epub 2020 May 19.

The Eye Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, United States. Electronic address:

Objective: To assess whether 6 mm optical coherence tomography (OCT) scans, which image the macula, can distinguish complete from partial posterior vitreous detachment (PVD) in comparison to 16.5 mm OCT scans, which image the macula, optic nerve, and midperiphery.

Design: Retrospective cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.oret.2020.05.006DOI Listing

Elevated vitreous αB-crystallin in patients with rhegmatogenous retinal detachment and association with proliferative vitreoretinopathy and retinal detachment area.

Int Ophthalmol 2020 May 21. Epub 2020 May 21.

College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.

Purpose: To investigate the relationship between αB-crystallin levels in the vitreous of patients with rhegmatogenous retinal detachment (RRD) and correlate these levels with the presence of proliferative vitreoretinopathy (PVR) and to the extent of RRD.

Methods: Prospective, cross-sectional study. Vitreous samples were collected from twenty-six patients with RRD at the surgical repair. Read More

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http://dx.doi.org/10.1007/s10792-020-01425-1DOI Listing

Primary Retinal Detachment Outcomes Study (PRO Study): Pseudophakic Retinal Detachment Outcomes-PRO Study Report #3.

Ophthalmology 2020 May 8. Epub 2020 May 8.

The Retina Service of Wills Eye Hospital, Mid-Atlantic Retina, Philadelphia, PA.

Objective: This study evaluates outcomes of comparable pseudophakic rhegmatogenous retinal detachment (RRD) treated with pars plana vitrectomy (PPV) or PPV with scleral buckle (PPV-SB).

Design: Multicenter, retrospective, interventional cohort study. Subjects, Participants, and/or Controls: Data were gathered from patients from multiple retina practices in the United States with RRD in 2015. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.05.005DOI Listing

Questions on Rhegmatogenous Retinal Detachment and the Day of the Week of Repair or Diagnosis.

JAMA Ophthalmol 2020 May 21. Epub 2020 May 21.

Royal Victoria Infirmary, Newcastle-Upon-Tyne, United Kingdom.

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http://dx.doi.org/10.1001/jamaophthalmol.2020.1554DOI Listing

Questions on Rhegmatogenous Retinal Detachment and the Day of the Week of Repair or Diagnosis-Reply.

JAMA Ophthalmol 2020 May 21. Epub 2020 May 21.

Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California.

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http://dx.doi.org/10.1001/jamaophthalmol.2020.1867DOI Listing

Spectral optical coherence tomography findings in patients with ocular toxoplasmosis: A case series study.

Ann Med Surg (Lond) 2020 Jun 24;54:125-128. Epub 2020 Apr 24.

Department of Ophthalmology, Farhat Hached Hospital, Sousse, Tunisia.

Purpose: Ocular toxoplasmosis is the most common cause of infectious uveitis worldwide. The diagnosis of ocular toxoplasmosis is primarily clinical when it is a typical presentation.With an atypical presentation in the fundus, parasitological diagnosis is a decisive contribution, as well as multimodal imaging. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231836PMC

Effectiveness of different silicone oil remove methods after vitrectomy and light silicone oil tamponade in elderly patients.

Ann Palliat Med 2020 May 8. Epub 2020 May 8.

Department of Ophthalmology, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou 545006, China.

Background: During the remove of oil from the silicone oil-filled eye after vitrectomy, perfusion fluid is often mistakenly aspirated when mechanical force is used to remove the oil. This leads to a sudden sharp drop in intraocular pressure and collapse of the eyeball, which may cause complications. The aspiration of perfusion fluid can be detected when the oil is removed manually, and the force of the hand and location of the aspiration can be adjusted to remove the silicone oil instead. Read More

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http://dx.doi.org/10.21037/apm-20-949DOI Listing

Preoperative factors to select vitrectomy or scleral buckling for retinal detachment in microincision vitrectomy era.

Graefes Arch Clin Exp Ophthalmol 2020 May 19. Epub 2020 May 19.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background: To determine the preoperative factors associated with selecting scleral buckling (SB) or pars plana vitrectomy (PPV) to treat rhegmatogenous retinal detachments (RRDs) in the era of microincision vitrectomy surgery.

Methods: A nationwide, multicenter, observational study in the Japan Retinal Detachment Registry was done. From February 2016 to March 2017, 3446 cases were registered, and 3219 among them were analyzed. Read More

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http://dx.doi.org/10.1007/s00417-020-04744-2DOI Listing

Influence of pigment epithelial detachment on visual acuity in neovascular age-related macular degeneration.

Surv Ophthalmol 2020 May 16. Epub 2020 May 16.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore. Electronic address:

Pigment epithelial detachment (PED), the anatomical separation of the retinal pigment epithelium (RPE) from the Bruch's membrane, is common in many chorioretinal diseases, including neovascular age-related macular degeneration (nAMD). PED is present in about 30% to 80% of nAMD patients based on the CATT, EXCITE, and VIEW studies. The influence of PED on visual acuity is controversial as a result of inconsistent results reported by various studies. Read More

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http://dx.doi.org/10.1016/j.survophthal.2020.05.003DOI Listing

Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents targeting vitreous collagen liquefaction as well as vitreoretinal adhesion.

Sci Rep 2020 May 19;10(1):8250. Epub 2020 May 19.

Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Induction of posterior vitreous detachment (PVD) by pharmacologic vitreolysis has been largely attempted through the use of enzymatic reagents. Ocriplasmin has been the only FDA-approved clinical reagent so far. Several adverse effects of ocriplasmin have emerged, however, and the search for alternative PVD-inducing reagents continues. Read More

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http://dx.doi.org/10.1038/s41598-020-64931-3DOI Listing

Expanding the phenotype spectrum associated with pathogenic variants in the COL2A1 and COL11A1 genes.

Ann Hum Genet 2020 May 19. Epub 2020 May 19.

Department of Biology and Medical Genetics, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.

We report the clinical findings of 26 individuals from 16 unrelated families carrying variants in the COL2A1 or COL11A1 genes. Using Sanger and next-generation sequencing, 11 different COL2A1 variants (seven novel), were identified in 13 families (19 affected individuals), all diagnosed with Stickler syndrome (STL) type 1. In nine families, the COL2A1 disease-causing variant arose de novo. Read More

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http://dx.doi.org/10.1111/ahg.12386DOI Listing

Study of toxoplasmosis and toxocariasis in patients suffering from ophthalmic disorders using serological and molecular methods.

Int Ophthalmol 2020 May 18. Epub 2020 May 18.

Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: Toxoplasma gondii is an intracellular protozoan parasite that can cause ocular toxoplasmosis with most complications such as retinal detachment. Toxocara parasite, round worm, found in dogs and cats appears as larva migrans in humans can cause serious ocular complications such as debilitating vision loss.In Khuzestan province, southwest of Iran, T. Read More

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http://dx.doi.org/10.1007/s10792-020-01393-6DOI Listing

Association between the patterns of diabetic macular edema and photoreceptors' response after intravitreal ranibizumab treatment: a spectral-domain optical coherence tomography study.

Int Ophthalmol 2020 May 18. Epub 2020 May 18.

2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: To analyze photoreceptors' condition after intravitreal ranibizumab treatment according to the pattern of diabetic macular edema (DME) on spectral-domain optical coherence tomography (SD-OCT).

Methods: Retrospective study includes 58 treatment naïve patients with DME, treated with intravitreal ranibizumab injections and followed up for at least 12 months. Patients were classified based on DME morphology on SD-OCT into: diffuse macular edema, cystoid macular edema (CME) and serous retinal detachment with CME (SRD/CME). Read More

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http://dx.doi.org/10.1007/s10792-020-01423-3DOI Listing

Adams Oliver syndrome: A mimicker of familial exudative vitreoretinopathy.

Am J Ophthalmol Case Rep 2020 Sep 22;19:100715. Epub 2020 Apr 22.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To describe an infant with Adams Oliver syndrome (AOS) with ocular signs similar to familial exudative vitreoretinopathy.

Observations: A full-term female infant presented with a congenital scalp defect, hypoplasia of the fingers and toes along with a radial retinal fold in the right eye and tractional retinal detachment in the left eye. Fluorescein angiography findings included peripheral retinal nonperfusion, irregular vascular sprouting beyond the vascular-avascular junction, pinpoint areas of hyperfluorescence as well as late peripheral and posterior vascular leakage. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217917PMC
September 2020

Analysis of the rates of emulsification in intraocular silicone oil tamponades of differing viscosities.

Int J Ophthalmol 2020 18;13(5):761-765. Epub 2020 May 18.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.

Aim: To investigate the rates of emulsification in silicone oil (SO) tamponades of differing viscosities used during pars plana vitrectomy (PPV) in the treatment of complicated vitreoretinal diseases.

Methods: This study was a prospective randomized clinical trial. Totally 290 cases with greater likelihoods of secondary detachment were included and randomly grouped into either Siluron 2000 (=143) or Siluron 5000 (=147) SO tamponades with 23-gauge PPV. Read More

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http://dx.doi.org/10.18240/ijo.2020.05.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201346PMC

Large choroidal metastasis with exudative retinal detachment as presenting manifestation of small cell lung cancer: A case report.

Respir Med Case Rep 2020 4;30:101074. Epub 2020 May 4.

Unit of Ocular Oncology, Neuromuscular and Sense Organs Department, Careggi University Hospital, Florence, Italy.

A 64-year-old man, diagnosed with a retinal detachment of his left eye, was sent to our hospital to evaluate vitreoretinal surgery. Left eye best-corrected visual acuity was hand motion. Fundus examination showed a voluminous slightly pigmented choroidal neoformation with secondary retinal detachment. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218149PMC

Granulomatous reaction to migrating silicone oil clinically mimicking a xanthelasma: A case report.

Int J Surg Case Rep 2020 May 7;70:182-184. Epub 2020 May 7.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Introduction: Silicone oil has been used for many years in retinal surgeries for retinal detachment. One of its reported complications is oil migration to the periorbital area, resulting in granulomatous reaction.

Presentation Of Case: A 56-year-old lady, with history of retinal detachment that was repaired by vitrectomy, silicone oil removal and epi-retinal membrane peeling, presented to us with unilateral ptosis and a skin lesion that resembled xanthelasma. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229421PMC

Adenoma and Adenocarcinoma of the Retinal Pigment Epithelium: A Review of 51 Consecutive Patients.

Ophthalmol Retina 2020 Mar 18. Epub 2020 Mar 18.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Purpose: To describe the clinical and imaging characteristics, pathologic features, and management options of retinal pigment epithelium (RPE) adenoma/adenocarcinoma.

Design: Retrospective case series.

Participants: Fifty-one patients with RPE adenoma/adenocarcinoma. Read More

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http://dx.doi.org/10.1016/j.oret.2020.03.008DOI Listing

Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy.

Hum Gene Ther 2020 May 15. Epub 2020 May 15.

AGTC, 482476, Preclinical R&D, Cambridge, Massachusetts, United States;

Recombinant adeno-associated viral (rAAV) vector-mediated gene therapy is being developed to treat X-linked retinitis pigmentosa (XLRP) in patients with mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. In preparation for a clinical gene therapy trial, we conducted dose range-finding (DRF) studies with an AAV2 capsid with three surface tyrosine residues changed to phenylalanine (AAV2tYF) vector administered by subretinal injection in a naturally occurring RPGR-mutant canine model (XLPRA2) to compare two different human RPGR (hRPGR) transgenes and to establish a reasonable starting dose for a clinical trial. Different dose levels of two candidate vectors (0. Read More

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http://dx.doi.org/10.1089/hum.2019.337DOI Listing

Increased Glial Fibrillary Acid Protein and Vimentin in Vitreous Fluid as a Biomarker for Proliferative Vitreoretinopathy.

Invest Ophthalmol Vis Sci 2020 May;61(5):22

,.

Purpose: Glial fibrillary acid protein (GFAP) and vimentin are type III intermediate filament proteins, ubiquitously expressed in retinal glial cells. Under retinal stress, both GFAP and vimentin are well-known sensitive markers for retinal gliosis. However, little is known about whether these proteins are released into the vitreous body in response to retinal gliosis or are related to the severity of retinal gliosis seen in proliferative vitreoretinopathy (PVR). Read More

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http://dx.doi.org/10.1167/iovs.61.5.22DOI Listing

Evaluation of Functional Outcomes and OCT-Biomarkers after Intravitreal Dexamethasone Implant for Postoperative Cystoid Macular Edema in Vitrectomized Eyes.

J Ophthalmol 2020 28;2020:3946531. Epub 2020 Apr 28.

Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.

Purpose: To evaluate the efficacy of dexamethasone implant (DEX) for the treatment of postoperative cystoid macular edema (PCME) in vitrectomized eyes and to investigate visual and morphological OCT predictive factors.

Methods: In this retrospective study, eyes with PCME after vitrectomy were treated with at least one DEX injection and were observed over 12 months. Indications for surgery were epiretinal membrane (ERM) or rhegmatogenous retinal detachment (RRD) without macular involvement. Read More

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http://dx.doi.org/10.1155/2020/3946531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204163PMC

Evaluation of primary internal limiting membrane peeling in cases with rhegmatogenous retinal detachment.

Int J Retina Vitreous 2020 7;6. Epub 2020 May 7.

1Faculty of Medicine, Minia University, Minia, Egypt.

Background: Epiretinal membranes (ERMs) have been reported after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD). Peeling of the internal limiting membrane (ILM) can prevent post-PPV ERM formation but has a potential negative impact on macular structure and function.

Purpose: To investigate the anatomical and functional outcomes of ILM peeling during PPV for primary RRD. Read More

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http://dx.doi.org/10.1186/s40942-020-00213-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204288PMC

Dimple in vascularized serous pigment epithelial detachment secondary to neovascular age-related macular degeneration.

Graefes Arch Clin Exp Ophthalmol 2020 May 14. Epub 2020 May 14.

Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil University Paris Est Créteil, 40 Avenue de Verdun, 94000, Créteil, France.

Background: To describe the "dimple," a previously unreported structural optical coherence tomography (OCT) finding in vascularized serous pigment epithelial detachment (PED) secondary to neovascular age-related macular degeneration (AMD).

Methods: Retrospective, longitudinal, case series study. Clinical charts and multimodal imaging including OCT (structural and angiography) and dye-based angiography (fluorescein and indocyanine green) examinations of patients with dimple-defined as a localized invagination of the vascularized serous PED-were analyzed in 2 high-volume referral centers. Read More

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http://dx.doi.org/10.1007/s00417-020-04732-6DOI Listing
May 2020
1.908 Impact Factor

Non-contact wide-angled visualization with chandelier-assisted scleral buckling for primary uncomplicated rhegmatogenous retinal detachment.

Graefes Arch Clin Exp Ophthalmol 2020 May 14. Epub 2020 May 14.

Asociados de Macula, Vitreo y Retina de Costa Rica, Primer Piso Torre Mercedes Paseo Colon, San Jose, Costa Rica.

Purpose: To report our experience in non-contact wide-angled visualization with chandelier-assisted scleral buckling (SB) in uncomplicated primary rhegmatogenous retinal detachments (RRD).

Methods: Retrospective case series of 282 eyes that underwent non-contact wide-angled visualization with chandelier-assisted SB and were followed for a mean of 13.5 months. Read More

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http://dx.doi.org/10.1007/s00417-020-04737-1DOI Listing

Impact of contact versus non-contact wide-angle viewing systems on outcomes of primary retinal detachment repair (PRO study report number 5).

Br J Ophthalmol 2020 May 14. Epub 2020 May 14.

Mid Atlantic Retina, Wills Eye Hospital, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA

Background/aims: Vitrectomy to repair retinal detachment is often performed with either non-contact wide-angle viewing systems or wide-angle contact viewing systems. The purpose of this study is to assess whether the viewing system used is associated with any differences in surgical outcomes of vitrectomy for primary non-complex retinal detachment repair.

Methods: This is a multicenter, interventional, retrospective, comparative study. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315948DOI Listing

Tamponade in surgery for retinal detachment associated with proliferative vitreoretinopathy.

Cochrane Database Syst Rev 2020 05 13;5:CD006126. Epub 2020 May 13.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Background: Retinal detachment (RD) with proliferative vitreoretinopathy (PVR) often requires surgery to restore normal anatomy and to stabilize or improve vision. PVR usually occurs in association with recurrent RD (that is, after initial retinal re-attachment surgery), but occasionally may be associated with primary RD. Either way, for both circumstances a tamponade agent (gas or silicone oil) is needed during surgery to reduce the rate of postoperative recurrent RD. Read More

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http://dx.doi.org/10.1002/14651858.CD006126.pub4DOI Listing

Self-Made Sleeve for Chandelier Light Simulation.

Retina 2020 May 12. Epub 2020 May 12.

Department of Ophthalmology, Medical University of Graz/Austria, Graz, Austria.

Purpose: To develop a quick and cost-effective alternative to a chandelier light for vitrectomy.

Methods: The surgical material available in an ophthalmologic operating room was used to create a sleeve for the vitrectomy light probe and tested on 30 consecutive retinal detachment cases for feasibility.

Results: A 64 × 5-mm cotton swab stick was cut into the length of the light probe minus the length of the trocar and subsequently pierced by a blunt needle. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002847DOI Listing

VISUAL IMPAIRMENT AND MACULAR VASCULAR REMODELING SECONDARY TO RETROGRADE MACULOPATHY IN RETINAL DETACHMENT TREATED WITH SILICON OIL TAMPONADE.

Retina 2020 May 12. Epub 2020 May 12.

Department of Ophthalmology, New Civil Hospital, Strasbourg University Hospital, FMTS, Strasbourg, France.

Purpose: To assess the frequency of macular cysts (MCs) in retinal detachment treated with silicone oil and evaluate their impact on visual acuity and macular vascularization using optical coherence tomography-angiography.

Methods: Forty-three eyes of 41 patients treated with silicone oil for retinal detachment were retrospectively studied. Best-corrected visual acuity and 6- × 6-mm optical coherence tomography-angiography examination at least 3 months after silicone oil removal were reviewed. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002812DOI Listing

Modeling retinal detachment associated with hemorrhage by Monte Carlo simulation.

Authors:
Tarek A Al-Saeed

Appl Opt 2020 Apr;59(12):3614-3618

In this work we study fundus reflection in the case of retinal detachment. Vitreous humor builds up beneath the retina through a break in the retina or when there is traction on the retina. Further, we assume that this detachment is associated with hemorrhage in regions both above and below the retina. Read More

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http://dx.doi.org/10.1364/AO.385247DOI Listing

Unexplained Visual Loss After Silicone Oil Removal: A 7-Year Retrospective Study.

Ophthalmol Ther 2020 May 12. Epub 2020 May 12.

Ophthalmology Department, Centro Hospitalar São João, Oporto, Portugal.

Introduction: Unexplained visual loss after removal of silicone oil from the eye has been described. The purpose of this study is to determine the incidence of unexplained loss of visual acuity after SO removal and to provide possible explanations for this phenomenon.

Methods: This retrospective study included patients that underwent vitreoretinal surgery, at Centro Hospitalar São João, between January of 2012 and October of 2018. Read More

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http://dx.doi.org/10.1007/s40123-020-00259-5DOI Listing