Search Our Scientific Publications & Authors

Exp Eye Res 2021 May 7:108615. Epub 2021 May 7.

Department of Ophthalmology, Centre hospitalier de l'Université de Montréal (CHUM), 1051 Sanguinet, D.01.2273, Montreal, Quebec, H2X 3E4, Canada. Electronic address:

Animal models of the Boston keratoprosthesis type 1 (KPro) are needed to study glaucoma damage after KPro implantation to control confounding comorbidities common in human KPro recipients. The purpose of this study was to determine the feasibility of establishing a reproducible mouse model of glaucoma after KPro surgery, specifically that of a miniaturized mouse model of KPro (mKPro). In the present study, a total of 20 corneas of donor C57BL/6 mice (n = 10) were implanted in one eye of each recipient BALB/C mice (n = 20), assembled as part of the mKPro, either with or without intraoperative lensectomy. Read More

Tissue Cell 2021 Apr 28;72:101547. Epub 2021 Apr 28.

Department of Ophthalmology, The second Hospital of Hebei Medical University, Shijiazhuang, 05000, China. Electronic address:

Proliferative vitreoretinopathy (PVR) is a serious ophthalmic disease and characterized by the formation of proliferative membranes by retinal pigment epithelial (RPE) cells. In PVR, the contraction and traction of the fibrocellular membranes cause retinal detachment, which can cause reduction surgery for retinal detachment to fail. Fibroblast growth factor-2 (FGF-2) causes RPE cells to form extracellular matrix (ECM), promotes chemotaxis, mitosis, and positively promotes the disease process of PVR. Read More

Ophthalmology 2021 May 4. Epub 2021 May 4.

Children's University Hospital, Dublin, Ireland; Technological University Dublin, Dublin, Ireland.

Objective: The prevalence of myopia is increasing around the world, stimulating interest in methods to slow its progression. The primary justification for slowing myopia progression is to reduce the risk of vision loss through sight-threatening ocular pathology in later life. The paper analyzes whether the potential benefits of slowing myopia progression by one diopter justify the potential risks associated with treatments. Read More

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211009095. Epub 2021 Apr 20.

Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education & Research, Gorimedu, India.

Purpose: The aim of this study is to describe the complications and outcome of sutureless scleral fixated intraocular lens (SFIOL) implantation in traumatic aphakia.

Setting: The study was conducted in a tertiary eye care centre in South India.

Design: The study involved a retrospective data analysis. Read More

J Med Case Rep 2021 May 7;15(1):255. Epub 2021 May 7.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.

Background: Hypotony maculopathy has been classically reported as a complication of glaucoma surgery or ocular trauma. There have been only a few reports of hypotony maculopathy following pars plana vitrectomy (PPV). Here, we report two cases of hypotony maculopathy occurring after PPV for epiretinal membrane (ERM) removal and characteristic photoreceptor folds observed on optical coherence tomography (OCT). Read More

Vet Ophthalmol 2021 May 6. Epub 2021 May 6.

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.

Objective: To describe clinical and histopathologic pre-operative diagnoses as well as associated post-operative complications following orbital silicone implantation in dogs undergoing enucleation and evaluate owner satisfaction.

Animals Studied: One hundred and eighty-six dogs who underwent enucleation with orbital implant.

Procedures: Medical records from dogs that underwent enucleation with orbital implant performed at Virginia-Maryland Veterinary Teaching Hospital between 2007 and 2019 were reviewed. Read More

J Ophthalmol 2021 16;2021:6627677. Epub 2021 Apr 16.

Department of Surgical Sciences, Eye Clinic Section, University of Turin, Turin 10122, Italy.

Purpose: To evaluate the efficacy of intravitreal dexamethasone implant (DEX) for the treatment of macular oedema secondary to vitrectomy for epiretinal membrane (ERM) and retinal detachment (RD) by conducting a systematic review with meta-analysis of published studies.

Methods: Studies reporting clinical outcomes of DEX use for the treatment of macular oedema secondary to ERM and RD vitrectomy were searched on PubMed and Embase databases. The primary outcome was best-corrected visual acuity (BCVA) change between baseline and post-DEX treatment, reported as mean difference (MD) with 95% confidence interval (CI). Read More

Sci Rep 2021 May 5;11(1):9559. Epub 2021 May 5.

Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

This 5-year ecological study assessed the association between meteorological factors and rhegmatogenous retinal detachment (RRD) frequency in 571 eyes of 543 cases of primary RRD at the Jikei University Kashiwa Hospital, Japan. We examined the monthly and seasonal distributions of RRD frequency using one-way analysis of variance. We then evaluated the relationship between monthly RRD frequency and 36 meteorological parameters using Poisson regression analysis. Read More

Turk J Ophthalmol 2021 04;51(2):102-106

İstanbul Retina Institute, İstanbul, Turkey

Objectives: To investigate visual and anatomical outcomes of vitreoretinal surgeries in patients with Eales' disease.

Materials And Methods: In this retrospective study, 22 eyes of 21 patients with vitreous hemorrhage (VH) or tractional retinal detachment (TRD) secondary to Eales' disease who underwent vitreoretinal surgery between January 1997 and December 2015 and had at least 1 year of follow-up were included.

Results: The mean best corrected visual acuity (BCVA) was significantly higher at final visit (0. Read More

J Wound Ostomy Continence Nurs 2021 May-Jun 01;48(3):256-261

Vita Boyar, MD, Steven & Alexandra Cohen Children's Medical Center, New Hyde Park, New York; and Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

Background: Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF) that has been used as a systemic chemotherapy treatment of various malignancies in adults since 2000. It has been used for pediatric patients over the last decade. In addition, bevacizumab is used for neonatal intravitreal administration for retinopathy of prematurity, a major complication of preterm birth, characterized by incomplete and abnormal vascularization of the retina that can lead to retinal detachment and blindness without treatment. Read More

Mol Genet Genomic Med 2021 May 5:e1628. Epub 2021 May 5.

Department of Genetics, KFSHRC, Riyadh, Saudi Arabia.

Purpose: Stickler syndrome is a collagenopathy that is typically COL2A1-related (autosomal dominant) and less commonly related to other collagen gene mutations. Diagnosis is straightforward when a child has myopia or retinal detachment in the setting of classic diagnostic criteria such as hearing impairment, midfacial hypoplasia, and arthropathy. However, some children have primarily ocular disease with mild or no extraocular features. Read More

Am J Case Rep 2021 May 5;22:e930504. Epub 2021 May 5.

Department of Special Surgery, Division of Ophthalmology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

BACKGROUND Ocular siderosis is an uncommon cause of vision loss due to a retained ferrous intraocular foreign bodies (IOFB) that cause iron deposition in ocular tissues. The most common manifestations are cataract formation, diffuse pigmentary changes of the retinal pigment epithelium, iris heterochromia, dilated pupils, secondary glaucoma, iritis, and cystoid macular edema. CASE REPORT We report a case of 38-year-old man who presented with a left dilated pupil and visual field defect. Read More

Eur J Ophthalmol 2021 May 4:11206721211013651. Epub 2021 May 4.

Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russian Federation.

Purpose: To study the implementation of the new multimodal imaging-based classification system of central serous chorioretinopathy (CSCR).

Methods: Ninety-three eyes with CSCR with available fundus autofluorescence (FAF), optical coherence tomography (OCT), and OCT angiography at presentation were included in this study. An anonymous data set was classified by two masked graders. Read More

PLoS One 2021 4;16(5):e0251071. Epub 2021 May 4.

Department of Canine Genetics, Kennel Club Genetics Centre, Animal Health Trust, Kentford, Newmarket, United Kingdom.

Purpose: Three related male English Cocker Spaniels (ECS) were reported to be congenitally blind. Examination of one of these revealed complete retinal detachment. A presumptive diagnosis of retinal dysplasia (RD) was provided and pedigree analysis was suggestive of an X-linked mode of inheritance. Read More

Ocul Immunol Inflamm 2021 May 4:1-5. Epub 2021 May 4.

Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Duke University, Durham, North Carolina, USA.

To investigate the clinical outcomes of methicillin-resistant (MRSA) endophthalmitis. Clinical courses were reviewed for 17 eyes (15 patients) with endogenous MRSA endophthalmitis based on positive blood and vitreous culture or clinical suspicion between 2013 to 2019 at Duke University Hospitals. Of 17 eyes, initial VA ranged from 20/40 to light perception. Read More

Cornea 2021 Jun;40(6):679-684

Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY.

Purpose: The Boston keratoprosthesis (KPro) has been used for certain indications in pediatric patients with congenital corneal opacities. Here, we describe the use of a near-complete conjunctival flap at the time of Boston type 1 KPro surgery in pediatric patients, with the goal of improving pediatric KPro outcomes.

Methods: We performed a retrospective chart review of 21 eyes from 16 patients who received their first KPro before the age of 18 years at a tertiary care center in Rochester, NY. Read More

BMC Ophthalmol 2021 May 3;21(1):196. Epub 2021 May 3.

Ophthalmology Unit, Department of Medicine and Surgery, University Hospital of Parma, via Gramsci 14, 43126, Parma, Italy.

Background: To compare parsplana vitrectomy (PPV) with and without phacoemulsification to treat rhegmatogenous retinal detachment (RRD).

Methods: Subjects aged 48-65 years with RRD in a phakic eye due to superior retinal tears with an overall extension of retinal breaks < 90° underwent to PPV alone (group A); or PPV plus phacoemulsification (phacovitrectomy, PCV, group B). Post-operative follow-up visits occurred at 1 week, 1 month (m1), 3 months (m3), and 6 months (m6) after surgery. Read More

J Ophthalmol 2021 14;2021:6654604. Epub 2021 Apr 14.

Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan.

Purpose: To report a rare complication presenting as an isolated central epiretinal membrane (ERM) related to fovea-sparing internal limiting membrane (ILM) peeling technique.

Methods: Five patients who received fovea-sparing ILM peeling were enrolled. Postoperatively, an isolated central ERM developed. Read More

BMC Ophthalmol 2021 May 2;21(1):195. Epub 2021 May 2.

Department of Ophthalmology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu City, Chiba, 279-0021, Japan.

Background: Sympathetic ophthalmia (SO) is a bilateral diffuse uveitis that can arise after ocular trauma or ocular surgery in the inciting eye. Pars plana vitrectomy (PPV) is one of the risk factors for SO. Several reports have described SO developing after 23- and 25-G PPV, but none have described SO occurring after 27-G PPV. Read More

Surv Ophthalmol 2021 Apr 29. Epub 2021 Apr 29.

Hospital Universitario Austral, Pilar, Buenos Aires, Argentina.

Leukemia is a rare disease associated with high mortality rates. The presence of unilateral or bilateral serous retinal detachment (SRD) as a sign of choroidal infiltration can be one of the manifestations of acute leukemia, both as a primary sign or in a relapse. We consolidated the literature on SRD as a sign of leukemic choroidopathy regarding its epidemiology, clinical manifestations, and main imaging diagnostic tools. Read More

Klin Monbl Augenheilkd 2021 Apr 30;238(4):403-409. Epub 2021 Apr 30.

Department of Ophthalmology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland.

Purpose: Patients with carcinomas often share symptoms of vision deterioration as part of paraneoplastic retinopathy (PNR), based on a cross-reaction between antigens expressed by the underlying tumor and retinal proteins. However, some of the underlying symptoms may be explained by a drug-induced toxicity. The application of new therapeutic strategies with mitogen-activated protein kinase (MEK) and fibroblast growth factor receptor (FGFR) inhibitors in advanced cancers are still under evaluation for safety and tolerability, but also for dose-limiting toxicities. Read More

Klin Monbl Augenheilkd 2021 Apr 30;238(4):396-402. Epub 2021 Apr 30.

Department of Ophthalmology, Cantonal Hospital St. Gallen, Switzerland.

Background: To report visual outcomes of anti-vascular endothelial growth factor (anti-VEGF) therapy for exudative age-related macular degeneration (AMD) in a real-life setting.

Patients And Methods: Retrospective case series of consecutive patients treated with either ranibizumab and/or aflibercept for monolateral or bilateral exudative AMD. A physician established the indication for treatment and administered the injections. Read More

J Cataract Refract Surg 2021 Apr 5. Epub 2021 Apr 5.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 2000031, China; NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China.

Abstract: To evaluate the efficacy and complications of cataract surgery in high myopia, a comprehensive search query was conducted from January 2000 to August 2020. A total of 19586 highly myopic eyes from 28 studies were included. Modern cataract surgery turns out efficacious in highly myopic eyes with significant improvement of visual acuity. Read More

J Cataract Refract Surg 2021 Apr 5. Epub 2021 Apr 5.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea.

Purpose: To determine the incidence of retinal detachment following lens surgery in children and young adults with non-traumatic ectopia lentis.

Setting: Population-based claims data.

Design: Population-based retrospective cohort study. Read More

J Cataract Refract Surg 2021 Apr 26. Epub 2021 Apr 26.

1Departments of Ophthalmology and Visual Sciences, 2Pediatrics, and 3Neuroscience Washington University in St. Louis School of Medicine St. Louis, Missouri.

Purpose: Children with high ametropia who have difficulties with spectacle or contact lens wear benefit from gains in visual function after intraocular collamer lens (ICL) surgery. Here we assess safety by reporting rates and case specifics of peri-operative and longer-term adverse events (AE).[LINE SEPARATOR] SETTING:: St. Read More

Int Ophthalmol 2021 Apr 29. Epub 2021 Apr 29.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, Iran.

Purpose: To evaluate the frequency of retinal displacement after pars plana vitrectomy (PPV) using silicone oil tamponade in patients with rhegmatogenous retinal detachment (RRD).

Methods: Patients with fresh RRD were enrolled in this prospective interventional case series. A standard 3-port PPV with silicone oil tamponade was performed in all cases. Read More

J Ophthalmol 2021 8;2021:6694199. Epub 2021 Apr 8.

Ningbo Eye Hospital, Ningbo, China.

Objective: To examine the use of a viscoelastic agent instead of air in the vitreous cavity during surgery for scleral buckling.

Methods: This was a retrospective cohort study of patients who underwent scleral buckling surgery for bulging rhegmatogenous retinal detachment (RRD) at Ningbo Eye Hospital from 07/2016 to 12/2019. The patients were grouped into drainage, air injection, cryotherapy and explant (DACE) and drainage, viscoelastic injection, cryotherapy, and explant (DVCE) groups, which were comparatively assessed. Read More

Eur J Ophthalmol 2021 Apr 30:11206721211012856. Epub 2021 Apr 30.

Eye Clinic, Humanitas-Gradenigo Hospital, Torino, Italy.

Background: 3D heads-up visualization systems are aimed to improve the surgical experience by providing high-resolution imaging. Objective of our study is to analyze, over a long-time span, the grade of satisfaction and safety of day-to-day 3D surgery compared to standard surgery and to investigate the technical distinctiveness between the heads-up systems currently in use.

Methods: In this retrospective observational case series. Read More

J Clin Med 2021 Apr 25;10(9). Epub 2021 Apr 25.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 03080, Korea.

Intraocular foreign bodies (IOFBs) are critical ophthalmic emergencies that require urgent diagnosis and treatment to prevent blindness or globe loss. This study aimed to examine the various clinical presentations of IOFBs, determine the prognostic factors for final visual outcomes, establish diagnostic protocols, and update treatment strategies for patients with IOFBs. We retrospectively reviewed patients with IOFBs between 2005 and 2019. Read More