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Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, USA.

Purpose: To evaluate outcomes of small-gauge pars plana vitrectomy (PPV) for the treatment of rhegmatogenous retinal detachment (RD) without scleral-depressed shaving of the vitreous base.

Methods: Retrospective, consecutive case series. Surgical technique included small-gauge PPV (25G, 23G, 25G+ or 27G) and wide-angle vitrectomy viewing system in all cases. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):113-115

Background And Objective: To discuss the role of proportional reflux hydrodissection (PRH) during pars plana vitrectomy (PPV) in eyes with diabetic tractional retinal detachment (TRD).

Patients And Methods: In this retrospective study, records of patients with diabetic TRD involving the fovea undergoing PPV with the help of PRH between January 2015 to March 2017 were noted. PRH relies on the Constellation system's proportional reflux feature. Read More

Cir Cir 2019 ;87(2):136-140

Servicio de Oftalmología, Hospital Juárez de México. Ciudad de México, México.

Objective: To compare the frequency of anatomic and functional success, between eyes with uncomplicated rhegmatogenous retinal detachment treated with exoplant or vitrectomy.

Method: Non-experimental, retrospective, comparative and longitudinal study in patients with rhegmatogenous retinal detachment, <20/200 visual acuity and macular involvement, treated with exoplant (group 1) or vitrectomy (group 2), and 9 months follow up, without proliferative vitreoretinopathy or other vitreoretinal disease that reduced vision. The frequencies of anatomic success (attached retina) and functional success (visual acuity > 20/200) were compared between groups at the end of follow up (chi squared and odds ratio). Read More

Cir Cir 2019 ;87(2):215-218

Facultad de Medicina, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México.

Background: Pupillary block induced by silicon oil in vitrectomized patients is a common condition usually treated with Nd-YAG laser iridotomy or with surgical removal of silicon oil.

Case Report: A case of silicone oil pupillary block glaucoma successfully treated with a 30 G needle transfixion technique is described. We performed a non-complicated vitrectomy surgery for retinal detachment with proliferative vitreoretinopathy that included lensectomy, inferior peripheral iridectomy, and silicone oil injection. Read More

Am J Ophthalmol Case Rep 2019 Jun 25;14:1-4. Epub 2019 Jan 25.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.

Purpose: Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis, which occurs following penetrating eye injury or eye surgery. We report two cases of refractory SO in patients with a history of trabeculectomy, which were treated effectively with adalimumab.

Observations: Case 1: A 69-year-old male with a history of trabeculectomy for rubeotic glaucoma of the right eye, secondary to diabetic retinopathy 8 years prior, presented with a decrease in visual acuity of the left eye due to SO. Read More

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):167-169

Retina Institute, Eye Foundation Hospitals, Lagos, Nigeria.

Recent advances in macular hole surgery have significantly improved the rates of anatomical success. One important advance is the dye-assisted peeling of the internal limiting membrane (ILM) around the hole. In large holes (<400 μ), sometimes, ILM peeling alone is not enough to achieve closure, and this may be improved by inverting part of the peeled membrane and using it to cover the macular hole or inverting and tucking the ILM flap into the hole. Read More

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):161-162

Glaucoma Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.

Knobloch syndrome (KS) is typically characterized by high myopia, vitreoretinal degeneration, retinal detachment, and macular abnormalities. We report a case of glaucoma in KS, which represents the fourth reported case and the first description of the retinal events after the glaucoma procedure. Retinal detachment followed standard cyclophotocoagulation procedure for glaucoma in a 2-month-old boy. Read More

Ophthalmologica 2019 Feb 14:1-7. Epub 2019 Feb 14.

Department of Ophthalmology, College of Medicine, Hallym University, Hwaseong, Republic of Korea.

Purpose: To assess treatment efficacy of scleral buckling surgery with wide-field surgical microscope and 27-gauge (G) chandelier illumination for rhegmatogenous retinal detachment (RRD).

Methods: This study is a retrospective chart review of 29 eyes in 29 patients with RRD who underwent scleral buckling surgery with a wide-field surgical microscope and 27-G chandelier illumination fiber inserted into the sclera at the pars plana. Results are expressed as mean ± standard deviation. Read More

Eur J Ophthalmol 2019 Feb 13:1120672119827855. Epub 2019 Feb 13.

Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.

Purpose:: To compare the efficacy of ranibizumab and aflibercept in the treatment of diabetic macular edema associated with subfoveal retinal detachment.

Methods:: This is a retrospective, comparative study. The treatment-naïve diabetic macular edema patients who had diabetic macular edema associated with subfoveal retinal detachment and underwent intravitreal aflibercept or intravitreal ranibizumab treatment were included. Read More

PLoS One 2019 12;14(2):e0212284. Epub 2019 Feb 12.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objective: Accurate scleral marking of retinal breaks is essential for successful scleral buckling. This study aimed to investigate the use of wide-field fundus images obtained with an Optos for preoperative estimation of the distance from the limbus to the retinal breaks.

Methods And Analysis: This is a retrospective review of 29 eyes from 26 patients with rhegmatogenous retinal detachment who received scleral buckling with anatomically successful repair. Read More

Stem Cells Transl Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmacology, Physiology, and Neuroscience, Rutgers-New Jersey Medical School, Newark, New Jersey, USA.

Retinal cell therapy can have the objectives of rescue (i.e., modulation of metabolic abnormalities primarily for sight preservation) as well as replacement (i. Read More

Korean J Ophthalmol 2019 Feb;33(1):63-69

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.

Purpose: To evaluate the changes of axial length (AXL) in eyes with unilateral idiopathic central serous chorioretinopathy (CSC) after resolution of serous retinal detachment.

Methods: A total of 31 patients diagnosed with idiopathic unilateral CSC were included in this study. The changes of AXL according to serous retinal detachment were examined. Read More

Optom Vis Sci 2019 Feb 7. Epub 2019 Feb 7.

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.

Significance: During the acute stage of central serous chorioretinopathy (CSC) with retinal elevation, the spectral domain optical coherence tomography (SD-OCT) estimate of ganglion cell layer complex thickness is reduced. Thickness returns to normal after resolution of the event. Measurement error is at least partially responsible for this effect. Read More

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan.

Purpose: To evaluate real-world evidence for young Japanese patients with rhegmatogenous retinal detachment (RRD) by retrospectively examining surgical procedures and clinical outcomes in the Japan Clinical Retina Study group.

Methods: This was a multicentre retrospective study of the medical records of 562 young patients (384 males and 178 females; mean age: 33.0 ± 11. Read More

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Sydney Retina Clinic & Day Surgery, Sydney, NSW, Australia.

Purpose: To report 4-year outcomes following the switch to aflibercept in treatment-resistant neovascular age-related macular degeneration (nAMD).

Methods: In this prospective, open-label, non-controlled, clinical trial, 49 patients with treatment-resistant nAMD received 2 mg intravitreal aflibercept as three loading doses every 4 weeks, followed by injections every 8 weeks for the first 48 weeks, then an individualized regimen for a further 36 months, following previous treatment with ranibizumab and/or bevacizumab. Outcome measures included best-corrected visual acuity (BCVA), central retinal thickness (CRT), pigment epithelial detachment (PED) height and geographic atrophy (GA) surface area. Read More

Exp Eye Res 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, 1 East Jianshe Road, Zhengzhou, 450052, China. Electronic address:

Proliferative vitreoretinopathy (PVR) is the leading cause of retinal detachment failure. The mechanism of PVR development is complex and still not completely elucidated. There are no proven methods for early prevention or clinical treatment. Read More

Case Rep Womens Health 2019 Jan 23;21:e00098. Epub 2019 Jan 23.

Department of Obstetrics & Gynecology, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23704, United States.

Preeclampsia is a disease of pregnancy classically defined by the development of new-onset hypertension and proteinuria. Serous retinal detachment is a rare complication of severe preeclampsia that is associated with a high incidence of morbidity and mortality. We present the case of a 24-year-old primigravida who was diagnosed with preeclamptic serous retinal detachment at 30 weeks of gestation that occurred in the absence of hypertension. Read More

J Ophthalmol 2019 10;2019:3120960. Epub 2019 Jan 10.

Department of Medicine-Ophthalmology, University of Udine, Udine, Italy.

Purpose: To compare the anatomical and visual results and complications of 27-gauge versus 25-gauge transconjunctival sutureless vitrectomy for the management of primary rhegmatogenous retinal detachment.

Methods: A prospective, propensity score-matched 6-month study was performed. All patients underwent either 27-gauge or 25-gauge vitrectomy as the first surgical intervention and were followed up over a 6-month period, in order to evaluate anatomical success, change in best-corrected visual acuity (BCVA), and intraoperative and postoperative complications including intraocular pressure dysregulation. Read More

Mol Syndromol 2019 Jan 20;9(5):266-270. Epub 2018 Jul 20.

Department of Pediatric Genetics, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey.

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR; OMIM 152950) is a rare autosomal dominantly inherited syndrome. Mutations in the kinesin family member 11 () gene have been associated with this condition. Here, we report a de novo novel heterozygous missense mutation in exon 12 of the gene [c. Read More

Eur J Ophthalmol 2019 Feb 8:1120672119827772. Epub 2019 Feb 8.

3 Aix Marseille Université, CNRS, Institut Neurosciences Timone (INT), Marseille, France.

Purpose:: The etiology of torpedo maculopathy remains unknown, but it has been recently suggested that it could represent a persistent defect in the development of the retinal pigment epithelium. As retinal pigment epithelium and photoreceptors form a functional unit, an alteration of photoreceptor distribution or function is predictable. The aim of this study is to describe multimodal imaging, including adaptive optics, in three cases of torpedo maculopathy, and discuss its pathogenesis. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14354

Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Rationale: Increases in cosmetic laser use have led to recent reports of accidental retinal injuries, most of which are limited to the posterior pole. We report a case of peripheral retinal injury caused by a 1064-nm Nd:YAG: neodymium-doped yttrium aluminum garnet.

Patient Concerns: A 27-year-old Asian woman was admitted with scotoma symptoms in her right eye. Read More

BMJ Open Ophthalmol 2019 20;4(1):e000187. Epub 2019 Jan 20.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mt. Sinai, New York City, New York, USA.

Background/aims: Optical coherence tomography (OCT) has become standard of care in the diagnosis and management of a myriad of retinal and optic nerve pathology. Access to diagnostic equipment and skilled imaging personnel in the after-hours setting is often limited. We examined the utility and diagnostic indications for automated OCT in a high-volume after-hours clinic within an eye institute. Read More

Eye (Lond) 2019 Feb 6. Epub 2019 Feb 6.

Gazi University School of Medicine, Ankara, 06500, Turkey.

Purpose: To identify the characteristics of peripheral retinal anomalies associated with persistent fetal vasculature (PFV) and evaluate the complications and outcomes.

Methods: Retrospective, noncomparative case series of patients with PFV who underwent surgery. Type of PFV, presence of peripheral retinal anomalies, extent of the retrolental membrane, complications, and functional and anatomical results were evaluated. Read More

Vet Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee.

Objective: To determine long-term outcome of phacoemulsification in raptors at the University of Tennessee Veterinary Medical Center.

Animals Studied: Seven nonreleasable diurnal raptors including, four bald eagles (Haliaeetus leucocephalus), two red-tailed hawks (Buteo jamaicensis), and one peregrine falcon (Falco peregrinus) that had undergone phacoemulsification. All birds showed behavioral changes attributable to visual deficits prior to surgery. Read More

Vestn Oftalmol 2018 ;134(6):59-67

Novosibirsk State Regional Hospital, 130 Nemirovicha-Danchenko St., Novosibirsk, Russian Federation, 630008; Novosibirsk State Medical University, 52 Krasny Prospect, Novosibirsk, Russian Federation, 630008.

Purpose: To evaluate the clinical effectiveness of aflibercept in treatment of patients with neovascular age-related macular degeneration (nAMD).

Material And Methods: The first group included 156 treatment-naive nAMD patients (156 eyes). The second group consisted of 29 patients (38 eyes) with nAMD who had previously received at least 3 loading injections of 0. Read More

Vestn Oftalmol 2018 ;134(6):15-24

S.M. Kirov Military Medical Academy, Chair of Ophthalmology, 5 Klinicheskaya St., Saint Petersburg, Russian Federation, 194044.

Purpose: To identify the signs of leakage points in central serous chorioretinopathy (CSC) patients using optical coherence tomography (OCT) allowing focal laser photocoagulation (FLP) to be performed without the need for fluorescein angiography (FA) in their treatment; to evaluate the effectiveness and safety of the approach.

Material And Methods: The retrospective part of the study included 54 patients (54 eyes) with distinctive signs of CSC further confirmed by the presence of a leakage point as could be seen with FA. The number of pigment epithelial detachments (PED), the thickness of the photoreceptor outer segments (PROS) layer, maximum horizontal length of the photoreceptor thinning area, and morphological changes in the outer retinal layers were evaluated with OCT. Read More

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

Purpose: To describe the clinical and histopathologic features secondary to ocular and periocular snakebites in dogs requiring enucleation.

Methods: Retrospective review of patients with recorded snakebite envenomation from the archives of the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) and Texas A&M Veterinary Medical Teaching Hospital (1997-2017). The cases included in this study required witnessed snakebites to the dog by the owner, clinical signs supportive of periocular or ocular envenomation, and/or histopathologic lesions compatible with snakebites. Read More

Ophthalmology 2019 Jan 31. Epub 2019 Jan 31.

Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Associated Retinal Consultants, Royal Oak, MI.

Purpose: To report the structural and functional outcomes of the autologous neurosensory retinal transplant for closure of refractory large macular holes.

Design: Multicenter retrospective consecutive case series PARTICIPANTS: Forty-one eyes of 41 patients (27 female and 14 male) with a full thickness macular hole refractory to prior vitrectomy with internal limiting membrane peel and tamponade.

Methods: All patients underwent pars-plana vitrectomy, autologous neurosensory retinal transplant with either gas, silicone oil tamponade, or short-term Perfluoro-n-octane heavy-liquid tamponade. Read More

Am J Pathol 2019 Jan 31. Epub 2019 Jan 31.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Single nucleotide polymorphisms and rare mutations in Factor H (FH; official name CFH) are associated with age-related macular degeneration and atypical hemolytic uremic syndrome, a form of thrombotic microangiopathy. Mice with the FH W1206R mutation (FH) share features with human atypical hemolytic uremic syndrome. Here, we report that FH mice exhibited retinal vascular occlusion and ischemia. Read More

J Fr Ophtalmol 2019 Feb 30;42(2):133-137. Epub 2019 Jan 30.

Hôpital Abass-Ndao-de-Dakar, Dakar, Sénégal. Electronic address:

Purpose: To appreciate the epidemiological characteristics and to show the therapeutic aspects of the giant retinal tears.

Patients And Methods: We conducted a retrospective study from January 2014 to June 2017 on subjects with giant retinal tears. Patients with media opacities limiting examination were excluded. Read More

Retina 2019 Jan 29. Epub 2019 Jan 29.

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To evaluate the influence of silicone oil (SO) tamponade on retinal layers thickness and visual acuity in patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment.

Methods: This is a retrospective case series of consecutive patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment with SO tamponade. Visual acuity and central macular thickness were measured with SO and at least a month after SO removal (SOR). Read More

Hum Cell 2019 Jan 31. Epub 2019 Jan 31.

Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongti South Road, Chaoyang District, Beijing, 100020, China.

Diabetic retinopathy (DR) is one of the common microvascular complications of diabetes mellitus, which is the main cause of blindness in diabetic patients. Angiogenesis plays an important role in retinal detachment and retinal microvascular inflammation throughout the whole development of DR. This study aimed to investigate the regulatory effect and the potential mechanism of miR-377 on high glucose and hypoxia-induced angiogenesis and inflammation in human retinal endothelial cells, and found that the miR-377 level was significantly increased after high glucose and hypoxia-mimetic agent to simulate the DR milieu. Read More

Am J Ophthalmol Case Rep 2019 Mar 9;13:143-146. Epub 2019 Jan 9.

Miyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.

Purpose: The aim of this report was to describe a case of myopic foveoschisis and a macular hole with retinal detachment that resolved spontaneously.

Observations: A 62-year-old woman with bilateral blurred vision was referred to our department. Her best-corrected visual acuity (BCVA) was 0. Read More

Am J Ophthalmol Case Rep 2019 Mar 9;13:131-135. Epub 2019 Jan 9.

Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, Lyon, France.

Purpose: To present the case of a patient with a hypertensive choroidopathy and her follow-up using multimodal imaging; and to assess how wide-field swept-source (SS) Optical Coherence Tomography Angiography (OCTA) contributes to detecting the areas of hypoperfusion.

Observations: A 25-year-old white woman with terminal renal insufficiency, myopericarditis, and cerebrospinal fluid pressure of 37 mmHg indicating intracranial hypertension, presented with a painless loss of vision in both eyes. Her blood pressure was 190/135 mmHg. Read More

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Instituto de la Visión-Hospital La Carlota, Montemorelos, Nuevo León, México

Purpose: To compare the effectiveness of intravitreal ziv-aflibercept (IVZ) to intravitreal bevacizumab (IVB) administered preoperatively to patients undergoing pars plana vitrectomy (PPV) for severe manifestations of proliferative diabetic retinopathy (PDR).

Design: Randomised clinical trial (RCT).

Methods: Two hundred and six patients with PDR-related complications requiring PPV were randomised into one of two treatment groups: Group A received IVZ (1. Read More

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Vitreo-retinal Unit, Manchester Royal Eye Hospital, Manchester, UK.

We report the case of a 32-year-old Afrocaribbean man with known stage 3 proliferative sickle-cell retinopathy who presented with a mixed picture of tractional and rhegmatogenous macula off detachment. He underwent left primary 25 g vitrectomy with silicone oil, delamination and endolaser photocoagulation under a general anaesthetic. He, however, presented 48 hours postoperatively with gross anterior segment ischaemia. Read More

Arq Bras Oftalmol 2019 Mar-Apr;82(2):107-110. Epub 2019 Jan 24.

Centro de Oncologia Ocular, Departamento de Ofalmologia e Ciências Visuais, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the first three years of The Amazon Ocular Oncology Center, the first ocular cancer center in the North of Brazil.

Methods: Here, we report patient information including patients' age, gender, diagnosis, treatment, and city of origin.

Results: Two hundred and twenty-one patients were included on this study: 160 (72%) patients came from the city of Manaus, 52 (24%) from other cities in Amazonas, and 9 (4%) from other states. Read More

Retina 2019 Jan 24. Epub 2019 Jan 24.

Department of Ophthalmology, Southwest Hospital, Southwest Eye Hospital, Army Medical University, Chongqing, China.

Purpose: To compare the impact of surgical timing on anatomical and functional outcomes of vitrectomy for open-globe injury.

Methods: Fifty-three patients were entered into this prospective open-label study, with 26 patients randomized into early surgery group (vitrectomy conducted within 4 days) and 27 into delayed surgery group (vitrectomy performed between 10-14 days after injury). Six-month data were available for 46 patients and 7 were lost to follow-up. Read More

J Ophthalmol 2018 27;2018:9250425. Epub 2018 Dec 27.

Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang Province 325027, China.

Purpose: To report a new technique for sutureless intrascleral fixation of three-piece foldable intraocular lenses (IOLs) using 25-gauge trocars.

Methods: We performed this technique on patients with insufficient posterior capsule support. Seventeen eyes from 15 patients with aphakia, dislocated IOL, or subluxated crystalline lens undergoing posterior chamber sutureless implantation of an IOL were studied. Read More

Curr Res Transl Med 2019 Jan 23. Epub 2019 Jan 23.

Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, H1T1C8, Quebec, Canada.

Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) present two examples of proliferative retinopathy, characterized by the same stages of progression; ischemia of the retinal vessels, leads to hypoxia and to correct the problem there is the setting up of uncontrolled angiogenesis, which subsequently causes blindness or even detachment of the retina. The difference is the following; that DR initiated by the metabolic complications that are due to hyperglycemia, and ROP is induced by overexposure of the neonatal retina to oxygen. In this review, we will demonstrate the physiopathological mechanism of the two forms of proliferative retinopathy DR and ROP, in particular the role of the CD40/CD40L axis and IL-1 on vascular complications and onset of inflammation of the retina, the implications of their effects on the onset of pathogenic angiogenesis, thus understanding the link between platelets and retinal ischemia. Read More

Am J Ophthalmol 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia College of Physicians and Surgeons, New York, NY, USA; Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore.

Purpose: To determine factors predictive of anatomic, visual and financial outcomes after traditional and nontraditional primary pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RD).

Design: Retrospective interventional case series and cost comparison Methods: PARTICIPANTS: 178 eyes (156 patients) with PR-repaired primary RD by a single surgeon at a clinical practice from 1/2001-12/2013 and followed for ≥1 year. The cohort had 2 sub-groups: traditional (TPR) and nontraditional (NTPR) PR. Read More

J Fr Ophtalmol 2019 Feb 22;42(2):e37-e46. Epub 2019 Jan 22.

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU ForeSight, , 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, université de Versailles Saint-Quentin-en-Yvelines, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision, CNRS, UMR 7210, 75012 Paris, France. Electronic address:

Purpose: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN Gel Stent as a solo procedure or in association with phacoemulsification in patients with chronic open angle glaucoma (OAG).

Methods: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN gel stent. The main outcome measure was IOP reduction at 12 months follow-up. Read More

Invest Ophthalmol Vis Sci 2019 Jan;60(1):349-357

Havener Eye Institute, Department of Ophthalmology and Visual Science, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.

Purpose: Mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling is neuroprotective in some retinal damage models but its role in neuronal survival during retinal detachment (RD) is unclear. In addition, serous RDs are a prevalent side effect of MEK inhibitors (MEKi), blocking MAPK/ERK signaling for treatment of certain cancers. We tested the hypothesis that MEKi treatment in experimental RD would increase photoreceptor death. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14271

Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.

Rationale: We experienced 2 cases of retinal detachment (RD) with giant tears located in the intermediate periphery of the fundus. In this case report, we investigated the clinical characteristics in these 2 cases.

Patient Concerns And Diagnoses: Case 1 involved a 63-year-old male, who became aware of metamorphopsia and decreased visual acuity (VA) in his left eye. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14225

Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University.

The aim of this cross-sectional study is to evaluate vision-related quality of life (VRQoL) and depression in patients with rhegmatogenous retinal detachment (RRD).The VRQoL and depression were evaluated in 58 patients with unilateral RRD and 58 healthy controls, using the Chinese version of the National Eye Institute Visual Function Questionnaire (CHI-VFQ-25) and the Chinese version of Beck Depression Inventory-II, respectively.Composite scores of the CHI-VFQ-25 were significantly lower in the RRD patients, compared with the healthy controls (P < . Read More

Cell Biosci 2019 21;9:12. Epub 2019 Jan 21.

Department of Ophthalmology, Huaihe Hospital, Henan University, No.8 of Baobei Road, Kaifeng, 475000 People's Republic of China.

Background: Proliferative vitreoretinopathy (PVR) is a severe blinding complication of retinal detachment surgery. Increasing evidence demonstrate that PVR is associated with oxidative stress. Scutellarin is a natural flavone compound that has been reported to have anti-oxidative activity. Read More

Clin Ophthalmol 2019 14;13:169-176. Epub 2019 Jan 14.

Patient Access Services, Novartis Healthcare Private Limited, Hyderabad, India.

Purpose: The objective of this study was to estimate the cost impact of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy and its complications due to single-piece acrylic monofocal intraocular lenses (IOLs) in the healthcare setting of United Kingdom, Italy, and Denmark.

Materials And Methods: A hypothetical cost-consequence model was developed to estimate economic burden of Nd:YAG laser capsulotomy due to different single-piece acrylic monofocal IOLs. Cumulative incidence of Nd:YAG laser capsulotomy at 3 years after cataract surgery with five single-piece monofocal acrylic IOLs was sourced from retrospective data analysis of electronic medical records of cataract patients in the United Kingdom. Read More

J Fr Ophtalmol 2019 Feb 22;42(2):215-218. Epub 2019 Jan 22.

Service d'ophtalmologie, centre hospitalier de Versailles, 1, rue Richaud, 78000 Versailles, France; Inserm, centre d'investigation clinique 1423, centre hospitalier national des Quinze-Vingts, université Pierre et Marie-Curie-Paris 6, 75012 Paris, France.

J Glaucoma 2019 Jan 22. Epub 2019 Jan 22.

Glaucoma Research Center, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland.

Introduction: Kabuki syndrome (KS) is a rare congenital and polymalformative condition, traditionally associated with mental retardation, unusual facial features and skeletal abnormalities. We hereby describe a case of bilateral congenital glaucoma associated with MLL2-mutation Kabuki Syndrome. To the best of our knowledge, this is the first association of KS with congenital glaucoma. Read More

J Glaucoma 2019 Jan 22. Epub 2019 Jan 22.

Department of Ophthalmology, William Beaumont Hospital, Royal Oak, MI, USA.

Purpose: To report 4 previously undescribed postoperative complications in 4 cases of ab-interno XEN45 Gel Stent (XEN) implantation following uncomplicated surgeries.

Patients And Methods: A total of 51 consecutive XEN implantations performed between July 1, 2017 and April 30, 2018 were reviewed. All cases were performed by 7 experienced glaucoma surgeons affiliated with the William Beaumont Hospital Department of Ophthalmology. Read More