22,164 results match your criteria Retinal Cases & Brief Reports [Journal]


An investigation of the ocular toxic effects of levetiracetam therapy in children with epilepsy.

Childs Nerv Syst 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Medicine, Department of Child Neurology, Karadeniz Technical University, Trabzon, Turkey.

Objective: To investigate the potential toxic effects of levetiracetam monotherapy on ocular tissues in cases of pediatric epilepsy using optical coherence tomography (OCT).

Methods: Thirty epileptic children (group 1) receiving levetiracetam monotherapy at a dosage of 20-40 mg/kg/day for at least 1 year with a first diagnosis of epilepsy and 30 age- and gender-matched healthy children (group 2) were included in the study. In addition to a detailed eye examination, peripapillary retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, foveal thickness (FT), and central corneal thickness (CCT) were measured in all children by means of spectral domain OCT. Read More

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http://dx.doi.org/10.1007/s00381-019-04076-5DOI Listing
February 2019

Interocular Symmetry of Fixation, Optic Disc, and Corneal Astigmatism in Bilateral High Myopia: The Shanghai High Myopia Study.

Transl Vis Sci Technol 2019 Jan 13;8(1):22. Epub 2019 Feb 13.

Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People's Republic of China.

Purpose: We investigate the interocular symmetry of fixation, optic disc, and corneal astigmatism in bilateral high myopia, and evaluate the predictive relationships between them.

Methods: We enrolled 202 cases with bilateral high myopia. Fixation, in terms of the bivariate contour ellipse area (BCEA), was evaluated with the Macular Integrity Assessment microperimetry. Read More

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http://dx.doi.org/10.1167/tvst.8.1.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375117PMC
January 2019

Clinical efficacy evaluation of treatment of different degrees of retinal vein occlusion with ranibizumab combined with an argon ion laser.

Exp Ther Med 2019 Mar 21;17(3):1563-1568. Epub 2018 Dec 21.

Ophthalmological Center of Huizhou Municipal Central Hospital, Huizhou, Guangdong 516000, P.R. China.

The aim of this study was to evaluate the clinical efficacy of an intravitreal injection of ranibizumab combined with argon ion laser photocoagulation therapy in the treatment of different degrees of central retinal vein occlusion (CRVO). A total of 112 CRVO patients including 25 cases of trunk occlusion, 50 cases of branch occlusion and 37 cases of hemiretinal vein-occlusion were enrolled in this study. Patients were treated with an intravitreal injection of 0. Read More

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http://dx.doi.org/10.3892/etm.2018.7125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364225PMC

Novel Missense Mutations in Are Associated with Bestrophinopathies in Lebanese Patients.

Genes (Basel) 2019 Feb 18;10(2). Epub 2019 Feb 18.

Rammal Hassan Rammal Research Laboratory, PhyToxE research group, Department of Life and Earth Sciences, Faculty of Sciences, Lebanese University, Nabatieh 1700, Lebanon.

To identify () causative mutations in six Lebanese patients from three families, of whom four had a presumed clinical diagnosis of autosomal recessive bestrophinopathy (ARB) and two showed a phenotype with a single vitelliform lesion, patients were subjected to standard ophthalmic examinations. In addition, exons and their flanking regions were amplified and sequenced by Sanger sequencing. Co-segregation and detailed bio-informatic analyses were performed. Read More

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http://dx.doi.org/10.3390/genes10020151DOI Listing
February 2019

Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group.

Pathogens 2019 Feb 18;8(1). Epub 2019 Feb 18.

Assistance Publique-Hôpitaux de Marseille, Department of Neonatal Medicine; Hospital of the Conception, 13005 Marseille, France.

Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up and relapses lifelong. Despite the possible severity of outcome, congenital toxoplasmosis (CT) is a neglected disease. Read More

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http://dx.doi.org/10.3390/pathogens8010024DOI Listing
February 2019

Chandelier-assisted scleral buckling in an eye with longstanding inert foreign body with fresh rhegmatogenous retinal detachment.

Indian J Ophthalmol 2019 Mar;67(3):429-430

Department of Vitreoretina, Sankara Eye Hospital, Guntur Vijayawada Express Highway, Pedakakani, Guntur, Andhra Pradesh, India.

Intraocular foreign bodies (IOFBs) present in varied manners which in turn necessitate their removal in majority of the cases. A stone foreign body can remain inert inside the eye for years. Retinal detachment in eyes following penetrating trauma with an IOFB is common, but a combination of fresh rhegmatogenous retinal detachment in an eye with a longstanding inert stone foreign body is extremely rare. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1361_18DOI Listing

OCT angiography features of paracentral acute middle maculopathy.

Indian J Ophthalmol 2019 Mar;67(3):417-419

Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, 18 College Road, Chennai, Tamil Nadu, India.

Paracentral acute middle maculopathy (PAMM) refers to retinal lesions with changes in the inner nuclear layer on spectral domain optical coherence tomography (OCT). PAMM is associated with retinal vascular pathology involving the deep capillary plexus. We report two cases of PAMM in Indian subjects using multimodal imaging highlighting the OCT angiography (OCTA) findings. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1249_18DOI Listing

Early Identification of Central Retinal Artery Occlusion Using Point-of-care Ultrasound.

Clin Pract Cases Emerg Med 2019 Feb 4;3(1):13-15. Epub 2019 Jan 4.

University of Washington School of Medicine, Department of Emergency Medicine, Seattle, Washington.

A 69-year-old woman with a history of untreated hypertension presented with acute-onset monocular vision loss. Initial workup was delayed due to lack of immediate specialty consultation and dilated funduscopic exam. Point-of-care ultrasound in the emergency department identified a small hyperechoic structure within the distal area of the central retinal artery; in conjunction with specialty ophthalmologic evaluation in a tertiary care center, the diagnosis of central retinal artery occlusion was made. Read More

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http://dx.doi.org/10.5811/cpcem.2018.11.39406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366367PMC
February 2019

Homozygous variant in OTX2 and possible genetic modifiers identified in a patient with combined pituitary hormone deficiency, ocular involvement, myopathy, ataxia, and mitochondrial impairment.

Am J Med Genet A 2019 Feb 17. Epub 2019 Feb 17.

Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Here we report on a singleton patient affected by a complicated congenital syndrome characterized by growth delay, retinal dystrophy, sensorineural deafness, myopathy, ataxia, combined pituitary hormone deficiency, associated with mitochondrial impairment. Targeted clinical exome sequencing led to the identification of a homozygous missense variant in OTX2. Since only dominant mutations within OTX2 have been associated with cases of syndromic microphthalmia, retinal dystrophy with or without pituitary dysfunctions, this represents the first report of an OTX2 recessive mutation. Read More

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http://dx.doi.org/10.1002/ajmg.a.61092DOI Listing
February 2019

Acquired and progressive myelinated retinal nerve fibers in neurofibromatosis type 1.

J AAPOS 2019 Feb 14. Epub 2019 Feb 14.

Hospital de Santa Maria, Lisboa, Portugal; Clínica Universitária de Oftalmologia, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal .

Acquired myelinated retinal nerve fibers (MRNF) is rare. The reported cases occur after optic disk injuries. We describe a case of a patient with neurofibromatosis type 1 and bilateral optic pathway glioma, who after 3 years' follow-up developed unilateral MRNF. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.01.012DOI Listing
February 2019

Outcomes of small-gauge vitreoretinal surgery without scleral-depressed shaving of the vitreous base in the era of wide-angle viewing systems.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, USA.

Purpose: To evaluate outcomes of small-gauge pars plana vitrectomy (PPV) for the treatment of rhegmatogenous retinal detachment (RD) without scleral-depressed shaving of the vitreous base.

Methods: Retrospective, consecutive case series. Surgical technique included small-gauge PPV (25G, 23G, 25G+ or 27G) and wide-angle vitrectomy viewing system in all cases. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313626DOI Listing
February 2019

Considerations in multi-gene panel testing in pediatric ophthalmology.

J AAPOS 2019 Feb 12. Epub 2019 Feb 12.

National Eye Institute, National Institutes of Health, Bethesda, MD, 20892. Electronic address:

Multi-gene panel testing is used increasingly in ophthalmology practice as an efficient and cost-effective method for diagnosing inherited eye conditions. Panel testing is a powerful diagnostic tool, and it has the potential to reveal syndromic information in patients with seemingly isolated eye findings. This case series highlights our experience with 4 children in 3 families who were referred for evaluation of an isolated retinal degeneration and diagnosed with neuronal ceroid lipofuscinosis on panel testing. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.01.008DOI Listing
February 2019

Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma.

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):e1-e9

Background And Objective: To identify the clinical and imaging characteristics of isolated retinal astrocytic hamartomas (IRAH).

Patients And Methods: A case series of eight patients diagnosed with IRAH.

Results: The average age at diagnosis was 32 years (range: 9 years to 80 years). Read More

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http://dx.doi.org/10.3928/23258160-20190129-12DOI Listing
February 2019

Imaging of Epiretinal Membranes Using En Face Widefield Swept-Source Optical Coherence Tomography.

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):106-112

Background And Objective: Swept-source optical coherence tomography (SS-OCT) imaging was performed on eyes with epiretinal membranes (ERMs), and the extent of the ERMs were compared between the 12 mm × 12 mm scans and the more routine 6 mm × 6 mm field of view (FOV).

Patients And Methods: Eyes containing ERMs were imaged using a 12 mm × 12 mm SS-OCT scan. En face images derived from vitreoretinal interface (VRI) slabs were reviewed to assess the full extent of the ERM. Read More

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http://dx.doi.org/10.3928/23258160-20190129-07DOI Listing
February 2019

Characterization of Patients With Geographic Atrophy in Routine Clinical Practice.

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):93-98

Background And Objective: Geographic atrophy (GA) affects millions of patients with age-related macular degeneration (AMD) worldwide, leading to significant, irreversible visual impairment. This study aims to characterize the visual impairment of patients with GA in a routine clinical practice.

Patients And Methods: This single-center, cross-sectional study used a novel natural language processing to select 1,045 GA cases utilizing the macula examination records from 19,359 patients with AMD. Read More

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http://dx.doi.org/10.3928/23258160-20190129-05DOI Listing
February 2019

Effective treatment of refractory sympathetic ophthalmia with glaucoma using adalimumab.

Am J Ophthalmol Case Rep 2019 Jun 25;14:1-4. Epub 2019 Jan 25.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.

Purpose: Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis, which occurs following penetrating eye injury or eye surgery. We report two cases of refractory SO in patients with a history of trabeculectomy, which were treated effectively with adalimumab.

Observations: Case 1: A 69-year-old male with a history of trabeculectomy for rubeotic glaucoma of the right eye, secondary to diabetic retinopathy 8 years prior, presented with a decrease in visual acuity of the left eye due to SO. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360245PMC
June 2019
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Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans.

Afr Health Sci 2018 Dec;18(4):909-916

Faculty of Health Sciences, University of Fort Hare, East London, South Africa.

Background: This study determined the diagnostic performance of new biomarkers for a composite diagnosis of non-communicable diseases (NCDs) among Central Africans.

Methods: This case-control study was conducted at LOMO Medical Centre, Kinshasa, DR Congo (DRC) between January - December, 2008. The cases comprised 226 participants with concurrent presence of at least 2 or more of NCDs. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354856PMC
December 2018

Subretinal Hypopyon in Presumed Tubercular Uveitis: A Report of Two Cases.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):163-166

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Subretinal hypopyon is an uncommon entity which has been described in ocular infections and inflammations including endophthalmitis, acute retinal necrosis, and sympathetic ophthalmia. The authors report subretinal hypopyon in two cases of presumed tubercular uveitis which responded well to antitubercular therapy (ATT). The first case was a 47-year-old male with bilateral peripapillary chorioretinitis with a subretinal hypopyon. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_187_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348936PMC
February 2019

Diagnostic Accuracy of a Device for the Automated Detection of Diabetic Retinopathy in a Primary Care Setting.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands.

Objective: To determine the diagnostic accuracy in a real-world primary care setting of a deep learning-enhanced device for automated detection of diabetic retinopathy (DR).

Research Design And Methods: Retinal images of people with type 2 diabetes visiting a primary care screening program were graded by a hybrid deep learning-enhanced device (IDx-DR-EU-2.1; IDx, Amsterdam, the Netherlands), and its classification of retinopathy (vision-threatening [vt]DR, more than mild [mtm]DR, and mild or more [mom]DR) was compared with a reference standard. Read More

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http://dx.doi.org/10.2337/dc18-0148DOI Listing
February 2019

Multimodal imaging evaluation of combined hamartoma of the retina and retinal pigment epithelium.

Eur J Ophthalmol 2019 Feb 14:1120672119831223. Epub 2019 Feb 14.

1 Department of Ophthalmology, Vitreoretinal Service, Catholic University of Rome, Rome, Italy.

Purpose:: Combined hamartoma of the retina and retinal pigment epithelium is a rare benign tumor characterized by a variable combination of glial, vascular, and pigmented components. The purpose of our study was to analyze the features of combined hamartoma of the retina and retinal pigment epithelium on optical coherence tomography angiography.

Methods:: Small case series of two cases of combined hamartoma of the retina and retinal pigment epithelium with macular and optic nerve involvement, evaluated with multimodal imaging including optical coherence tomography, fluorescein angiography, and optical coherence tomography angiography. Read More

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http://dx.doi.org/10.1177/1120672119831223DOI Listing
February 2019

[Diagnostic Strategy and Therapeutic Dilemma in Acute Posterior and Panuveitis].

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Augenklinik, Universitätsspital Basel, Schweiz.

Acute posterior and panuveitis mostly affect younger patients and affect both eyes in more than half of cases. Because of the severe consequences in the clinical course, rapid and broad differential diagnosis are critical steps. Permanent loss of vision after a delay in starting therapy and the initiation of ineffective treatment are both serious risks. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0828-7395
Publisher Site
http://dx.doi.org/10.1055/a-0828-7395DOI Listing
February 2019
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IMPACT OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY REVIEW STRATEGY ON DETECTION OF CHOROIDAL NEOVASCULARIZATION.

Retina 2019 Feb 11. Epub 2019 Feb 11.

Vitreoretinal Service, Cleveland Clinic Foundation, Cole Eye Institute, Cleveland, Ohio.

Purpose: To compare optical coherence tomography angiography (OCTA) review strategies for optimizing choroidal neovascularization (CNV) detection.

Methods: Eyes with CNV in the differential diagnosis were imaged with the Avanti RTVue XR HD (Optovue, Fremont, CA). Three modalities of review for CNV presence were used in each case: a single report generated using automated segmentation within Avanti software; a continuous slab descent video OCTA export; and a manual segmentation approach using cross-sectional OCT with decorrelation signal overlay. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002443DOI Listing
February 2019

Fully Convolutional Networks for Monocular Retinal Depth Estimation and Optic Disc-Cup Segmentation.

IEEE J Biomed Health Inform 2019 Feb 14. Epub 2019 Feb 14.

Glaucoma is a serious ocular disorder for which the screening and diagnosis are carried out by the examination of the optic nerve head (ONH). The color fundus image (CFI) is the most common modality used for ocular screening. In CFI, the central region which is the optic disc and the optic cup region within the disc are examined to determine one of the important cues for glaucoma diagnosis called the optic cup-to-disc ratio (CDR). Read More

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http://dx.doi.org/10.1109/JBHI.2019.2899403DOI Listing
February 2019

A new association: acute macular neuroretinopathy in acute optic neuritis.

Acta Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Clinical Research Department, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

Background: Acute optic neuritis (AON) is a common optic nerve disease leading to retrograde degeneration of optic nerve axons, reflected by thinning of the inner retinal layers on optical coherence tomography. On the contrary, acute macular neuroretinopathy (AMN) type 2 is a rare outer retinal disorder that leads to thinning of the outer nuclear layers and is diagnosed by multimodal imaging. The aim of this study was to report a new association between these two diseases. Read More

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http://dx.doi.org/10.1111/aos.14054DOI Listing
February 2019
1 Read

Real-time tracking of surgical instruments based on spatio-temporal context and deep learning.

Comput Assist Surg (Abingdon) 2019 Feb 14:1-10. Epub 2019 Feb 14.

c Lab of Laparoscopic Technique and Engineering, Qilu Hospital of Shandong University , Jinan , China.

ABSTARCT Real-time tool tracking in minimally invasive-surgery (MIS) has numerous applications for computer-assisted interventions (CAIs). Visual tracking approaches are a promising solution to real-time surgical tool tracking, however, many approaches may fail to complete tracking when the tracker suffers from issues such as motion blur, adverse lighting, specular reflections, shadows, and occlusions. We propose an automatic real-time method for two-dimensional tool detection and tracking based on a spatial transformer network (STN) and spatio-temporal context (STC). Read More

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http://dx.doi.org/10.1080/24699322.2018.1560097DOI Listing
February 2019

Evolution of retinal changes measured by optical coherence tomography in the assessment of hydroxychloroquine ocular safety in patients with systemic lupus erythematosus.

Lupus 2019 Feb 12:961203319829826. Epub 2019 Feb 12.

1 Autoimmune Diseases Research Unit, Department of Internal Medicine, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, University of The Basque Country, Bizkaia, Basque Country, Spain.

Objective: The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces cohort treated with hydroxychloroquine (HCQ).

Methods: SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer thickness (GCLT) and qualitative data of retinal pigment epithelium (RPE) and external retina (ExtR) were collected prospectively. Read More

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http://dx.doi.org/10.1177/0961203319829826DOI Listing
February 2019
1 Read

Non-invasive diagnosis of retinoblastoma using cell-free DNA from aqueous humour.

Br J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

West Midlands Regional Genetics Service, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

Retinoblastoma is the most common eye malignancy in childhood caused by mutations in the gene. Both alleles of the gene must be mutated for tumour development. The initial mutation may be constitutional germline or somatic (originating in one retinal cell only). Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3130
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313005DOI Listing
February 2019
1 Read

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration.

Nat Genet 2019 Feb 11. Epub 2019 Feb 11.

Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Genome-wide association studies (GWAS) have identified genetic variants at 34 loci contributing to age-related macular degeneration (AMD). We generated transcriptional profiles of postmortem retinas from 453 controls and cases at distinct stages of AMD and integrated retinal transcriptomes, covering 13,662 protein-coding and 1,462 noncoding genes, with genotypes at more than 9 million common SNPs for expression quantitative trait loci (eQTL) analysis of a tissue not included in Genotype-Tissue Expression (GTEx) and other large datasets. Cis-eQTL analysis identified 10,474 genes under genetic regulation, including 4,541 eQTLs detected only in the retina. Read More

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http://dx.doi.org/10.1038/s41588-019-0351-9DOI Listing
February 2019
29.352 Impact Factor

Subconjunctival Orbital Fat Prolapse: An Update on Diagnosis and Management.

Semin Ophthalmol 2019 Feb 9:1-5. Epub 2019 Feb 9.

c Oculoplastic Department , Institut Català de Retina , Barcelona , España.

Subconjunctival prolapse of orbital fat is an uncommon clinical entity in which intraconal orbital fat herniates into the subconjunctival space. Its diagnosis is mainly clinical in character and usually based on palpation, patient clinical history, and lesion features along with a slit lamp examination. Its pathophysiology remains unclear. Read More

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http://dx.doi.org/10.1080/08820538.2019.1576743DOI Listing
February 2019

High efficient differentiation of human adipose-derived stem cells into retinal pigment epithelium-like cells in medium containing small molecules inducers with a simple method.

Tissue Cell 2019 Feb 12;56:52-59. Epub 2018 Dec 12.

Farabi Eye Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The induction of retinal pigmented epithelium cells (RPE) is one of the most important objectives in research focused on treating retinal degenerative diseases. The present study aims to differentiate human adipose stem cells (hADSCs) into RPE cells for replacement therapies in cases of retinal degenerative diseases.

Methods: Lipoaspirate-derived human adipose stem cells (LA-hADSCs) were obtained from abdominal samples and examined by immunocytochemistry for the expression of mesenchymal adipose stem cell markers. Read More

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http://dx.doi.org/10.1016/j.tice.2018.12.003DOI Listing
February 2019

Evaluation of the Association between the Risk of Central Retinal Artery Occlusion and the Concentration of Environmental Air Pollutants.

J Clin Med 2019 Feb 7;8(2). Epub 2019 Feb 7.

Department and Clinic of Ophthalmology, Wroclaw Medical University, Ul. Borowska 213, 50-556 Wroclaw, Poland.

The purpose of the retrospective, population-based study was to assess the relationship between the risk of central retinal artery occlusion (CRAO) and the level of air pollutants. This study identified 2.272 cases of newly diagnosed CRAO registered in the Polish National Health Service database. Read More

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http://dx.doi.org/10.3390/jcm8020206DOI Listing
February 2019

[Retinovascular Findings in Susac's Syndrome].

Laryngorhinootologie 2019 Feb 8;98(2):108-113. Epub 2019 Feb 8.

Background: Susac syndrome is a vasculopathy affecting the central nervous system, retina and cochlea leading to the triad encephalopathy, branch retinal artery occlusions and hearing loss. To date, about 300 cases have been described in the literature.

Patients/methods: Three patients with confirmed Susac syndrome were evaluated for disease-specific retinal pathologies. Read More

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http://dx.doi.org/10.1055/a-0747-6968DOI Listing
February 2019

A Propensity-Score Matching Comparison between 27-Gauge and 25-Gauge Vitrectomy Systems for the Repair of Primary Rhegmatogenous Retinal Detachment.

J Ophthalmol 2019 10;2019:3120960. Epub 2019 Jan 10.

Department of Medicine-Ophthalmology, University of Udine, Udine, Italy.

Purpose: To compare the anatomical and visual results and complications of 27-gauge versus 25-gauge transconjunctival sutureless vitrectomy for the management of primary rhegmatogenous retinal detachment.

Methods: A prospective, propensity score-matched 6-month study was performed. All patients underwent either 27-gauge or 25-gauge vitrectomy as the first surgical intervention and were followed up over a 6-month period, in order to evaluate anatomical success, change in best-corrected visual acuity (BCVA), and intraoperative and postoperative complications including intraocular pressure dysregulation. Read More

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http://dx.doi.org/10.1155/2019/3120960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348836PMC
January 2019
1 Read

Role of anterior segment optical coherence tomography for safer management of mature white cataracts.

J Cataract Refract Surg 2019 Feb 4. Epub 2019 Feb 4.

Dhami Eye Care Hospital, Ludhiana, Punjab, India.

Purpose: Role of anterior segment optical coherence tomography (AS-OCT) for safer management of mature white cataracts.

Setting: Patients with mature white cataracts attending the outpatient department of a tertiary eye care hospital, aspiring to have cataract surgery performed, were scheduled for elective phacoemulsification and intraocular lens implantation by two surgeons during the period of October 2017 to March 2018.

Design: A prospective interventional study of 30 patients. Read More

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http://dx.doi.org/10.1016/j.jcrs.2018.11.009DOI Listing
February 2019
2.722 Impact Factor

Papillophlebitis as manifestation of polyarteritis nodosa.

Arch Soc Esp Oftalmol 2019 Feb 4. Epub 2019 Feb 4.

Servicio de Cardiología, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Las Palmas, España.

A 35 year-old-man diagnosed with polyarteritis nodosa developed papillophlebitis on his left eye. Throughout the evolution of the disease, he had a macular oedema treated with intravitreal injections of aflibercept, with adequate recovery of visual acuity. He also had episcleritis on the other eye. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.12.007DOI Listing
February 2019

Multimodal imaging of torpedo maculopathy including adaptive optics.

Eur J Ophthalmol 2019 Feb 8:1120672119827772. Epub 2019 Feb 8.

3 Aix Marseille Université, CNRS, Institut Neurosciences Timone (INT), Marseille, France.

Purpose:: The etiology of torpedo maculopathy remains unknown, but it has been recently suggested that it could represent a persistent defect in the development of the retinal pigment epithelium. As retinal pigment epithelium and photoreceptors form a functional unit, an alteration of photoreceptor distribution or function is predictable. The aim of this study is to describe multimodal imaging, including adaptive optics, in three cases of torpedo maculopathy, and discuss its pathogenesis. Read More

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http://dx.doi.org/10.1177/1120672119827772DOI Listing
February 2019

The location of exon 4 mutations in RP1 raises challenges for genetic counselling and gene therapy.

Am J Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, OX3 9DU; Nuffield Department of Clinical Neurosciences, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU.

Purpose: Mutations in the photoreceptor gene RP1 lead to recessive or dominantly inherited retinitis pigmentosa (RP). Since the dominantly inherited phenotype is generally milder than recessive cases, it raises the possibility that it could arise by haploinsufficiency, however most mutations are in the terminal exon 4, which would be predicted to generate truncated proteins. We therefore assessed a cohort of RP patients with confirmed mutations in RP1 in order to examine the genetic basis of the exon 4 mutations. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.027DOI Listing
February 2019
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ALTERATION OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN A PATIENT WITH OCULAR ISCHEMIC SYNDROME.

Retin Cases Brief Rep 2019 Feb 4. Epub 2019 Feb 4.

Department of Ophthalmology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Purpose: To analyze optical coherence tomography angiography images in ocular ischemic syndrome (OIS) before and after carotid artery stenting.

Methods: We report the case of an 80-year-old man with a history of hypertension and diabetes mellitus who developed OIS in the right eye due to right internal carotid artery stenosis 2 years earlier. After visual acuity declined in the left eye 2 years later, a neurosurgeon discovered left internal carotid artery stenosis, which led to the diagnosis of OIS in the left eye as well. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000857DOI Listing
February 2019
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Anterior elongation of the retina in persistent fetal vasculature: emphasis on retinal complications.

Eye (Lond) 2019 Feb 6. Epub 2019 Feb 6.

Gazi University School of Medicine, Ankara, 06500, Turkey.

Purpose: To identify the characteristics of peripheral retinal anomalies associated with persistent fetal vasculature (PFV) and evaluate the complications and outcomes.

Methods: Retrospective, noncomparative case series of patients with PFV who underwent surgery. Type of PFV, presence of peripheral retinal anomalies, extent of the retrolental membrane, complications, and functional and anatomical results were evaluated. Read More

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http://dx.doi.org/10.1038/s41433-019-0345-yDOI Listing
February 2019
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Early-scatter laser photocoagulation promotes the formation of collateral vessels in branch retinal vein occlusion.

Eur J Ophthalmol 2019 Feb 5:1120672119827857. Epub 2019 Feb 5.

Department of Ophthalmology, Dong-A University Hospital, Busan, Republic of Korea.

Purpose:: To investigate the effect of early-scatter laser photocoagulation on the formation of collateral vessels in branch retinal vein occlusion.

Methods:: The medical records of 40 cases (40 patients) of branch retinal vein occlusion with macular edema were retrospectively reviewed. Of them, 23 patients were treated with intravitreal bevacizumab injection and 17 patients underwent intravitreal bevacizumab injection with additional laser treatment. Read More

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http://dx.doi.org/10.1177/1120672119827857DOI Listing
February 2019

Polypoidal Choroidal Vasculopathy: Outer Retinal and Choroidal Changes and Neovascularization Development in the Fellow Eye.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):590-598

Department of Ophthalmology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: We investigated the outer retinal, RPE, and choroidal changes and the development of choroidal neovascularization (CNV) in fellow eyes of patients with unilateral polypoidal choroidal vasculopathy or aneurysmal type 1 neovascularization (PCV/AT1).

Methods: In this retrospective observational cohort study, 263 patients with unilateral PCV/AT1 were enrolled. Fundus photography, enhanced depth imaging optical coherence tomography, and indocyanine green angiography at baseline and follow-up were analyzed. Read More

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http://dx.doi.org/10.1167/iovs.18-24244DOI Listing
February 2019
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[Clinical polymorphism of splice site mutations in the ABCA4 gene].

Vestn Oftalmol 2018 ;134(6):83-93

Research Centre for Medical Genetics, 1 Moskvorech'e St., Moscow, Russian Federation, 115478.

ABCA4 is one of the main genes whose mutations are associated with various inherited retinal diseases (IRD) such as Stargardt disease, cone dystrophy, cone-rod dystrophy, and retinitis pigmentosa. The severity of retinal dystrophy phenotype may be related to the degree of mutation pathogenicity, which depends on the localization in various regulatory regions of the gene and the effect on the amino acid composition of the protein molecule. The article describes two clinical cases of patients with splice site mutations in the compound heterozygous state with missense mutations in the ABCA4 gene with various phenotypic manifestations, which demonstrate the importance of molecular genetic analysis in patients with IRD. Read More

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http://dx.doi.org/10.17116/oftalma201813406183DOI Listing
January 2018
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[Optical coherence tomography in diagnostics and treatment of central serous chorioretinopathy].

Vestn Oftalmol 2018 ;134(6):15-24

S.M. Kirov Military Medical Academy, Chair of Ophthalmology, 5 Klinicheskaya St., Saint Petersburg, Russian Federation, 194044.

Purpose: To identify the signs of leakage points in central serous chorioretinopathy (CSC) patients using optical coherence tomography (OCT) allowing focal laser photocoagulation (FLP) to be performed without the need for fluorescein angiography (FA) in their treatment; to evaluate the effectiveness and safety of the approach.

Material And Methods: The retrospective part of the study included 54 patients (54 eyes) with distinctive signs of CSC further confirmed by the presence of a leakage point as could be seen with FA. The number of pigment epithelial detachments (PED), the thickness of the photoreceptor outer segments (PROS) layer, maximum horizontal length of the photoreceptor thinning area, and morphological changes in the outer retinal layers were evaluated with OCT. Read More

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http://dx.doi.org/10.17116/oftalma201813406115DOI Listing
January 2018
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Case-control analysis identifies shared properties of rare germline variation in cancer predisposing genes.

Eur J Hum Genet 2019 Feb 4. Epub 2019 Feb 4.

Analytic and Translational Genetics Unit, MGH, Boston, MA, USA.

Along with traditional effects of aging and carcinogen exposure-inherited DNA variation has substantial contribution to cancer risk. Extraordinary progress made in analysis of common variation with GWAS methodology does not provide sufficient resolution to understand rare variation. To fulfill missing classification for rare germline variation we assembled dataset of whole exome sequences from>2000 patients (selected cases tested negative for candidate genes and unselected cases) with different types of cancers (breast cancer, colon cancer, and cutaneous and ocular melanomas) matched to more than 7000 non-cancer controls and analyzed germline variation in known cancer predisposing genes to identify common properties of disease-associated DNA variation and aid the future searches for new cancer susceptibility genes. Read More

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http://dx.doi.org/10.1038/s41431-019-0346-0DOI Listing
February 2019
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Molecular genetic analysis using targeted NGS analysis of 677 individuals with retinal dystrophy.

Sci Rep 2019 Feb 4;9(1):1219. Epub 2019 Feb 4.

Kennedy Center, Department of Clinical Genetics, Rigshospitalet, University of Copenhagen, Glostrup, DK2600, Denmark.

Inherited retinal diseases (IRDs) are a common cause of visual impairment. IRD covers a set of genetically highly heterogeneous disorders with more than 150 genes associated with one or more clinical forms of IRD. Molecular genetic diagnosis has become increasingly important especially due to expanding number of gene therapy strategies under development. Read More

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http://dx.doi.org/10.1038/s41598-018-38007-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362094PMC
February 2019
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Localization of nitro-tyrosine immunoreactivity in human retina.

Ann Anat 2019 Feb 1;223:8-18. Epub 2019 Feb 1.

Department of Anatomy, Neurobiology Laboratory, All India Institute of Medical Sciences, New Delhi, 110029, India.

Oxidative stress (OS) is associated with retinal aging and age-related macular degeneration (AMD). In both cases there are reports for the presence of markers of lipid peroxidation in retinal cells. We investigated if nitrosative stress also occurs in the human retina with aging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09409602193000
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http://dx.doi.org/10.1016/j.aanat.2019.01.006DOI Listing
February 2019
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Canine ocular and periocular snakebites requiring enucleation: A report of 19 cases.

Vet Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

Purpose: To describe the clinical and histopathologic features secondary to ocular and periocular snakebites in dogs requiring enucleation.

Methods: Retrospective review of patients with recorded snakebite envenomation from the archives of the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) and Texas A&M Veterinary Medical Teaching Hospital (1997-2017). The cases included in this study required witnessed snakebites to the dog by the owner, clinical signs supportive of periocular or ocular envenomation, and/or histopathologic lesions compatible with snakebites. Read More

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http://dx.doi.org/10.1111/vop.12638DOI Listing
February 2019
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Autologous Retinal Transplant For Refractory Macular Holes: Multicenter International Collaborative Study Group.

Ophthalmology 2019 Jan 31. Epub 2019 Jan 31.

Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Associated Retinal Consultants, Royal Oak, MI.

Purpose: To report the structural and functional outcomes of the autologous neurosensory retinal transplant for closure of refractory large macular holes.

Design: Multicenter retrospective consecutive case series PARTICIPANTS: Forty-one eyes of 41 patients (27 female and 14 male) with a full thickness macular hole refractory to prior vitrectomy with internal limiting membrane peel and tamponade.

Methods: All patients underwent pars-plana vitrectomy, autologous neurosensory retinal transplant with either gas, silicone oil tamponade, or short-term Perfluoro-n-octane heavy-liquid tamponade. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.027DOI Listing
January 2019
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Importance of ocular electrophysiology in the diagnosis of retinal dystrophies.

Arch Soc Esp Oftalmol 2019 Jan 30. Epub 2019 Jan 30.

UGC Oftalmología, Hospital Universitario Virgen Macarena, Sevilla, España; Departamento de Cirugía, Universidad de Sevilla, Sevilla, España.

Background And Objective: The diagnosis of retinal dystrophies is complex and is based on complete ophthalmological study, genetic study and electrophysiological studies (EPS). In this study, we intend to evaluate the role of electrophysiological and medical tests in the diagnosis of retinal dystrophies.

Material And Methods: A retrospective observational study was conducted on 50 selected patients that attended the Neurophysiology Department of the University Hospital Virgen Macarena. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.12.009DOI Listing
January 2019

[Giant retinal tears: Senegalese experience].

J Fr Ophtalmol 2019 Feb 30;42(2):133-137. Epub 2019 Jan 30.

Hôpital Abass-Ndao-de-Dakar, Dakar, Sénégal. Electronic address:

Purpose: To appreciate the epidemiological characteristics and to show the therapeutic aspects of the giant retinal tears.

Patients And Methods: We conducted a retrospective study from January 2014 to June 2017 on subjects with giant retinal tears. Patients with media opacities limiting examination were excluded. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.06.006DOI Listing
February 2019