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Arch Soc Esp Oftalmol 2019 Feb 12. Epub 2019 Feb 12.

Consorcio Hospital General Universitario de Valencia, Valencia, España.

Digital subtraction angiography (DSA) is a technique used in interventional radiology for the diagnosis of vascular cerebral conditions. Central retinal artery occlusion (CRAO) is a complication of endovascular procedures that involve atherosclerotic plaque removal with subsequent embolisation. The case is presented on a patient who noticed a sudden vision loss during a DSA. Read More

J Clin Med 2019 Feb 7;8(2). Epub 2019 Feb 7.

Department and Clinic of Ophthalmology, Wroclaw Medical University, Ul. Borowska 213, 50-556 Wroclaw, Poland.

The purpose of the retrospective, population-based study was to assess the relationship between the risk of central retinal artery occlusion (CRAO) and the level of air pollutants. This study identified 2.272 cases of newly diagnosed CRAO registered in the Polish National Health Service database. Read More

J Craniofac Surg 2019 Feb 2. Epub 2019 Feb 2.

Dr. YOURhinoclinic (Private Clinic), Istanbul, Turkey.

Purpose: Loss of vision is an extremely rare and unexpected complication following a routine uncomplicated nasal surgery. In majority of patients, visual loss has attributed to retinal emboli which occur with retrograde flow of the intra-arterially injected agents into the nasal cavity or direct trauma to the optic nerve. In this report, the authors present a patient with unilateral decreased vision due to branch retinal artery occlusion soon after a routine nasal surgery. Read More

J Am Heart Assoc 2019 Feb;8(3):e010509

1 Department of Neurosciences University of Calgary Alberta Canada.

Background Monocular vision loss, attributed to either central retinal artery occlusion ( CRAO ), branch retinal artery occlusion ( BRAO ), or ocular ischemic syndrome ( OIS ), is thought to be associated with an increased prevalence of cerebral infarcts. However, there is a paucity of data substantiating this. We aimed to investigate this relationship in a Canadian center and further understand the importance of associated internal carotid artery stenosis in potential clinical decision making. Read More

Mayo Clin Proc 2019 Feb;94(2):236-241

Department of Ophthalmology, Mayo Clinic, Rochester, MN; Department of Neurology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To determine the risk of ischemic stroke, transient ischemic attack (TIA), and amaurosis fugax around the time of central retinal artery occlusion (CRAO).

Patients And Methods: Patients at Mayo Clinic sites with a diagnosis code of CRAO from January 1, 2001, through September 9, 2016, were reviewed. New CRAOs were confirmed, and ischemic stroke, TIA, and amaurosis fugax events were tallied within 15 days before and after CRAO. Read More

J AAPOS 2019 Jan 30. Epub 2019 Jan 30.

Department of Ophthalmology, Casey Eye Institute, Oregon Health, and Science University, Portland, Oregon. Electronic address:

Surv Ophthalmol 2019 Jan 29. Epub 2019 Jan 29.

Department of Ophthalmology, University Hospitals and School of Medicine, Geneva, Switzerland.

The retinal ganglion cells infarcted in central retinal artery occlusion (CRAO) are the somata of the optic nerve axons, part of the central nervous system. Consequently, CRAO with inner retinal infarction is a small vessel stroke, usually with the devastating consequence of severe visual loss in the affected eye. At present, there is no generally accepted, evidence-based therapy of non-arteritic CRAO in contrast to ischemic cerebral stroke that has well accepted treatment protocols. Read More

Surv Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Bristol Eye Hospital , Bristol Royal Infirmary NHS Trust, Department of medical retina and uveitis, Bristol Eye Hospital, Lower Maudlin St, Bristol BS1 2LX. Electronic address:

Susac syndrome is a rare condition presumed to be immune-mediated occlusion of small arterial vasculature principally of the brain, inner ear, and retina. Clinically the syndrome manifests as a pathognomonic triad of encephalopathy, hearing loss, and branch retinal artery occlusion. Early recognition and diagnosis is important as delayed treatment may be profound and result in deafness, blindness, dementia and other neurological deficits. Read More

Am J Ophthalmol 2019 Jan 25. Epub 2019 Jan 25.

West Virginia University School of Medicine, 1 Medical Center Drive, Morgantown, WV.

Purpose: Central retinal artery occlusion (CRAO) confers a high risk of acute vascular ischemic events, including stroke and myocardial infarction (MI). Understanding the burden and risk factor profile of these ischemic events can serve as a valuable guide for ophthalmologists in the management and appropriate referral of these patients.

Design: Retrospective cross-sectional study METHODS: The Nationwide Inpatient Sample (NIS) was queried to identify all inpatient admissions with a diagnosis of CRAO in the United States between the years 2003 to 2014. Read More

PLoS One 2019 25;14(1):e0210505. Epub 2019 Jan 25.

Department of Ophthalmology, Ulm University, Ulm, Germany.

Objective: To analyze quality and frequency of OCTA artifacts and to evaluate their impact on the interpretability of OCTA images.

Design: 75 patients with diabetic retinopathy (DR), retinal artery occlusion (RAO), retinal vein occlusion (RVO), or neovascular age-related macular degeneration (nAMD) and healthy controls were enrolled in this cross-sectional study in the outpatient department of a tertiary eye care center.

Methods: All participants underwent an OCTA examination (spectral domain OCT Cirrus 5000 equipped with the AngioPlex module). Read More

Ocul Oncol Pathol 2019 Jan 30;5(1):50-53. Epub 2018 May 30.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Hemangioendothelioma is rarely encountered in the orbit. We present a patient with a growing orbital mass for whom surgical excision was planned. Two previous attempts at removing the mass failed due to profuse bleeding. Read More

Indian J Ophthalmol 2019 Feb;67(2):312-313

Department of Ophthalmolgy, S.S. Medical College, Rewa, Madhya Pradesh, India.

Indian J Ophthalmol 2019 Feb;67(2):273-274

Dr RP Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

Lancet 2019 01;393(10168):275

Department of Ophthalmology, Mohamed VI University Hospital of Marrakesh, Marrakesh, Morocco.

Biomaterials 2019 Mar 9;197:146-160. Epub 2019 Jan 9.

Departments of Anesthesiology, USA; Ophthalmology and Visual Science, College of Medicine, USA. Electronic address:

Retinal ischemia is a major cause of vision loss and impairment and a common underlying mechanism associated with diseases such as glaucoma, diabetic retinopathy, and central retinal artery occlusion. The regenerative capacity of the diseased human retina is limited. Our previous studies have shown the neuroprotective effects of intravitreal injection of mesenchymal stem cells (MSC) and MSC-conditioned medium in retinal ischemia in rats. Read More

Sci Rep 2019 Jan 14;9(1):80. Epub 2019 Jan 14.

Department of Ophthalmology, China-Japan Friendship Hospital, Beijing, 100029, China.

Retinal hypoperfusion injury is the pathophysiologic basis of ocular ischemic syndrome (OIS) which often leads to severe visual loss. In this study, we aimed to establish a rat model of retinal chronic hypoperfusion by bilateral common carotid artery occlusion (BCCAO) and observe changes in the retinal function and morphology. We found that model rats showed retinal arteriosclerosis, slight dilated retinal vein, small hemangiomas, hemorrhages, vascular segmental filling, and nonperfused areas after 2 weeks of BCCAO. Read More

J Stroke Cerebrovasc Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

A 23-year-woman was presented for sudden-onset monocular blindness. Branch retinal artery occlusion in the right eye and multiple brain embolism were detected. Trousseau syndrome due to bilateral ovarian cancer was diagnosed; no embolic events were observed after anticoagulant therapy and surgical resection. Read More

Acta Otorhinolaryngol Ital 2018 Dec;38(6):544-553

Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.

Susac syndrome, a rare autoimmune disorder first described as a classic triad (encephalopathy, branch retinal artery occlusion, and sensorineural hearing loss) in 1979 by renowned physician John O. Susac, has been an advancing area of clinical interest and scientific research over the last several decades. This comprehensive review aims to succinctly highlight the breadth and detail of this enigmatic disease, with a primary focus on otologic manifestations. Read More

J Cardiothorac Vasc Anesth 2018 Nov 24. Epub 2018 Nov 24.

Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL; Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL. Electronic address:

J Stroke Cerebrovasc Dis 2019 Feb 26;28(2):256-258. Epub 2018 Oct 26.

Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa. Electronic address:

Immunogenetics 2019 Jan 5. Epub 2019 Jan 5.

Department of Clinical Immunology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Deficiency of adenosine deaminase 2 (DADA2) is an autoinflammatory disease caused by autosomal recessive mutations in Cat Eye Syndrome Chromosome Region 1 (CECR1) gene. In this report, we aimed to describe the clinical manifestations, immunological features, genotype, and treatments of one Chinese patient with novel CECR1 gene mutations. This patient initially presented with recurrent fever and rashes from the age of 3 months, but no pathogen was found. Read More

PLoS One 2019 3;14(1):e0209118. Epub 2019 Jan 3.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Objectives: To investigate the characteristics and temporal changes in visual field defects (VFDs) in eyes with acute central retinal artery occlusion (CRAO).

Design: Retrospective, observational case series.

Methods: A total of 119 patients diagnosed with acute non-arteritic CRAO through examination with Goldmann perimetry were included among the patients who visited Seoul National University Bundang Hospital between January 2009 and December 2016. Read More

Korean J Intern Med 2018 Dec 28. Epub 2018 Dec 28.

Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.

Int J Ophthalmol 2018 18;11(12):2024-2026. Epub 2018 Dec 18.

General Hospital of Patras "Agios Andreas", Ophthalmology Clinic, Kalavriton 37, Patras 26335, Greece.

Neurologist 2019 Jan;24(1):17-21

Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.

Introduction: Takayasu arteritis is a large-vessel vasculitis that may cause oculo-cerebral ischemia. We report a patient with visual loss as initial manifestation, and discuss transcranial Doppler (TCD) findings before and after surgical revascularization.

Case Description: A 19-year-old female developed episodes of transient positional right vision loss, progressing to permanent right vision loss and bright light-induced left amaurosis. Read More

Am J Ophthalmol 2018 Dec 19. Epub 2018 Dec 19.

Atlanta, Georgia, USA.

Clin Exp Emerg Med 2018 Dec 31;5(4):278-281. Epub 2018 Dec 31.

Department of Ophthalmology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Central retinal artery occlusion (CRAO) is considered an ophthalmologic emergency. The prognosis of this disease is very poor. Currently, there is no generally effective therapy available to treat CRAO. Read More

Arch Soc Esp Oftalmol 2018 Dec 14. Epub 2018 Dec 14.

Departamento de Retina y Vítreo, Hospital General de México «Dr. Eduardo Liceaga», Ciudad de México, Estados Unidos Mexicanos. Electronic address:

Combined central retinal artery and vein occlusion is uncommon in adults and even more so in young people. The main origins are vasculitis and thromboembolic disorders. The prognosis is poor due to irreversible visual loss and the development of neovascular glaucoma (NVG). Read More

Korean J Ophthalmol 2018 12;32(6):519-520

Department of Ophthalmology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

J Mol Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Institute of Biomedicine, Jinan University, Guangzhou, China.

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) belong to the same peptide family and exert a variety of biological functions. Both PACAP and VIP have protective effects in several tissues. While PACAP is known to be a stronger retinoprotective peptide, VIP has very potent anti-inflammatory effects. Read More

Cesk Slov Oftalmol 2018 ;73(5-6):178-182

The review points to the issues of persistent hyaloid artery, more precisely to possible clinical features, the influence on visual functions and potential complications during intraocular surgeries. In professional journals we can find just few reviews regarding this rare deviation of the eye development, therefore we want to present our experience. The persistent hyaloid artery causes chronical local changes of eye background at both of our patients, retinal detachment and retinoschisis. Read More

J Neuroophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.

J Stroke Cerebrovasc Dis 2019 Feb 24;28(2):521. Epub 2018 Oct 24.

Professor of Neurology Director of Cerebrovascular Diseases University of Iowa. Electronic address:

Arch Soc Esp Oftalmol 2018 Nov 29. Epub 2018 Nov 29.

Departmento de Dermatología, Hospital Universitari i Politècnic La Fe, Valencia, España.

A 44 year-old Caucasian male with a history of plaque psoriasis currently being treated with ustekinumab presented with sudden loss of vision in his left eye. Fundus examination showed central retinal vein occlusion coexisting with central retinal artery occlusion. Posterior examination revealed mild polycythemia, being the underlying cause unknown. Read More

Neuroradiol J 2018 Dec 3:1971400918817149. Epub 2018 Dec 3.

2 Department of Neurosurgery, Juntendo University School of Medicine, Japan.

Purpose: We aimed to analyse the patency rate of the anterior choroidal artery, and presented imaging and neurological findings, after deployment of a flow diverter in the anterior choroidal artery in the treatment of patients with intracranial aneurysms.

Methods: Among the 139 patients who underwent a flow diverter deployment from December 2012 to September 2017 in our hospital, there were 21 patients (15.1%) for whom their anterior choroidal artery was covered for the procedure with a flow diverter. Read More

N Engl J Med 2018 Nov;379(22):2152-2159

From the Departments of Neurology (S.P., M.B.), Ophthalmology (L.H.Y.), and Radiology (R.G.), Harvard Medical School, the Department of Neurology, Brigham and Women's Hospital (S.P.), the Department of Ophthalmology, Massachusetts Eye and Ear (L.H.Y.), and the Departments of Neurology (M.B.) and Radiology (R.G.), Massachusetts General Hospital - all in Boston.

Acta Ophthalmol 2018 Nov;96 Suppl A113:1-44

Department of Ophthalmology, University of Iceland, Reykjavik, Iceland.

Purpose: Continuous peripheral pulse oximetry for monitoring adequacy of oxygenation is probably the most important technological advance for patients' monitoring and safety in the last decades. Pulse oximetry has the disadvantage of measuring the peripheral circulation, and the only mean to measure oxygen content of the central circulation is by invasive technology. Determination of blood oxyhaemoglobin saturation in the retinal vessels of the eye can be achieved noninvasively through spectrophotometric retinal oximetry which provides access to the central nervous system circulation. Read More

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(19):3956-3961

Tianjin First Center Hospital, Tianjin 300192, China.

Puerarin injection is commonly used in clinical treatment of coronary heart disease, angina pectoris, retinal artery, vein occlusion, sudden deafness and so on. This paper is aimed to evaluate the safety of puerarin injection in clinical use and explore the related factors that may cause its adverse reactions (ADRs), so as to find the warning signal of safety medication in time, put forward early warning, make early judgment and treatment, and ensure the safety of drug use. By strengthening surveillance, the best medication plan was established to prevent the occurrence of adverse reactions of puerarin injection and enhance people's awareness on the safety of puerarin injection. Read More

Indian J Ophthalmol 2018 Dec;66(12):1864

Department of Ophthalmology, Grant Medical College and Sir J.J. Group of Hospitals, Mumbai, Maharashtra, India.

Indian J Ophthalmol 2018 Dec;66(12):1862-1863

Department of Vitreo Retina, Aditya Birla Sankara Nethralaya, Mukundapur, Kolkata, West Bengal, India.

Indian J Ophthalmol 2018 Dec;66(12):1684-1694

Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, Iowa, USA.

The pathogeneses, clinical features, and management of central retinal artery occlusion (CRAO) are discussed. CRAO consists of the following four distinct clinical entities: non-arteritic CRAO (NA-CRAO), transient NA-CRAO, NA-CRAO with cilioretinal artery sparing, and arteritic CRAO. Clinical characteristics, visual outcome, and management very much depend upon the type of CRAO. Read More

Emerg Radiol 2018 Nov 16. Epub 2018 Nov 16.

Department of Radio-diagnosis, University College of Medical Sciences and GTB Hospital (University Of Delhi), Delhi, India.

Ocular emergencies contribute to a large proportion of ocular pathologies. These may even be organ-threatening diseases such as central retinal artery and vein occlusion or globe rupture. Conventional physical examination may not always be feasible in emergency situations but decision-making in time is critical in the interest of patient in few of these conditions. Read More

Exp Eye Res 2019 Feb 12;179:142-149. Epub 2018 Nov 12.

Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden; Department of Clinical Experimental Research, Glostrup Research Institute, Rigshospitalet, Glostrup, Denmark.

Retinal ischemia remains a major cause of blindness in the world with few acute treatments available. Recent emphasis on retinal vasculature and the ophthalmic artery's vascular properties after ischemia has shown an increase in vasoconstrictive functionality, as previously observed in cerebral arteries following stroke. Specifically, endothelin-1 (ET-1) receptor-mediated vasoconstriction regulated by the MEK/ERK1/2 pathway. Read More

Med Clin (Barc) 2018 Nov 10. Epub 2018 Nov 10.

Servicio de Oftalmología, Hospital Universitario 12 de Octubre, Madrid, España; Servicio de Reumatología, Hospital Universitario 12 de Octubre, Madrid, España.

BMJ Case Rep 2018 Nov 12;2018. Epub 2018 Nov 12.

Department of Internal Medicine, John H Stroger Jr Hospital of Cook County, Chicago, Illinois, USA.

A 23-year-old woman with history of systemic lupus erythematous presented with dizziness and headache and was admitted for the stroke workup. During her stay, she had sudden painless loss of vision in her right eye consistent with central retinal artery occlusion (CRAO). Ocular massage and paracentesis were attempted without success to resume the flow. Read More

QJM 2018 Nov 12. Epub 2018 Nov 12.

Jichi Medical University, Ophthalmology.

QJM 2018 Nov 3. Epub 2018 Nov 3.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan.

Eur J Ophthalmol 2018 Nov 5:1120672118809579. Epub 2018 Nov 5.

3 Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Purpose:: To report a case of Evans syndrome with a vascular occlusive event leading to severe loss of vision.

Case Report:: A 12-year-old boy with Evans syndrome presented with painless acute loss of vision in the left eye during a period of remission from the disease. Examination showed visual acuity of hand motion in the left eye, left relative afferent pupillary defect, pale optic nerve head, and attenuated vessels. Read More

Photodiagnosis Photodyn Ther 2018 Dec 28;24:372-376. Epub 2018 Oct 28.

Department of Ophthalmology, the First Affiliated Hospital of China Medical University. No. 155 Nanjing Bei Street, Heping District, Shenyang City, Liaoning Province, 110001, People's Republic of China; Department of Ophthalmology, Tacheng area people's Hospital, No. 22, Wenhua road Tacheng City, the Xinjiang Uygur Autonomous Region, People's Republic of China; Diabetic Eye Center of Liaoning province. No. 155 Nanjing Bei Street, Heping District, Shenyang City, Liaoning Province, 110001, People's Republic of China; The Key Laboratory of Endocrine diseases in Liaoning Province, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang City, Liaoning Province, 110001, People's Republic of China. Electronic address:

The purpose of this study is to describe the effects and complications of photodynamic therapy (PDT) on Chinese patients with circumscribed choroidal hemangioma (CCH). In this retrospective study, 22 CCH patients who underwent PDT performed 15 min after the injection of intravenous verteporfin (6 mg/m2)with multiple 83-second laser spots at 689 nm (50 J/cm2) were studied. Fluorescein angiography and/or indocyanine green angiography, B-scan ultrasonography and optical coherence tomography were performed in all patients. Read More