164,183 results match your criteria Retina Philadelphia Pa.[Journal]


Self-perception in Children Aged 3 to 7 Years With Amblyopia and Its Association With Deficits in Vision and Fine Motor Skills.

JAMA Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Importance: Deficits in fine motor skills and slow reading speed have been reported in school-aged children and adults with amblyopia. These deficits were correlated with lower self-perception of athletic and cognitive competence. Although perceived competence and social acceptance are key determinants of developing self-perception in young children, the association of amblyopia with self-perception and the association of altered self-perception with fine motor skills to date have not been reported for young children aged 3 to 7 years. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.7075DOI Listing
February 2019

Neurobiology of Photophobia.

J Neuroophthalmol 2019 Mar;39(1):94-102

Department of Anesthesia and Critical Care (RB, RN), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology (ABF), Children's Hospital Boston, Boston, Massachusetts.

Background: Photophobia is commonly associated with migraine, meningitis, concussion, and a variety of ocular diseases. Advances in our ability to trace multiple brain pathways through which light information is processed have paved the way to a better understanding of the neurobiology of photophobia and the complexity of the symptoms triggered by light.

Purpose: The purpose of this review is to summarize recent anatomical and physiological studies on the neurobiology of photophobia with emphasis on migraine. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000766DOI Listing

IMPACT OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY REVIEW STRATEGY ON DETECTION OF CHOROIDAL NEOVASCULARIZATION.

Retina 2019 Feb 11. Epub 2019 Feb 11.

Vitreoretinal Service, Cleveland Clinic Foundation, Cole Eye Institute, Cleveland, Ohio.

Purpose: To compare optical coherence tomography angiography (OCTA) review strategies for optimizing choroidal neovascularization (CNV) detection.

Methods: Eyes with CNV in the differential diagnosis were imaged with the Avanti RTVue XR HD (Optovue, Fremont, CA). Three modalities of review for CNV presence were used in each case: a single report generated using automated segmentation within Avanti software; a continuous slab descent video OCTA export; and a manual segmentation approach using cross-sectional OCT with decorrelation signal overlay. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002443DOI Listing
February 2019

ACUTE MACULAR AND PERIPAPILLARY ANGIOGRAPHIC CHANGES WITH INTRAVITREAL INJECTIONS.

Retina 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York.

Purpose: Intravitreal injections acutely and temporarily increase intraocular pressure (IOP), and this may have cumulative long-term effects including an increased risk for glaucoma surgery. This study was designed to measure retinal perfusion density changes on optical coherence tomography (OCT) angiography and OCT thickness alterations associated with acutely increased IOP after intravitreal injections.

Methods: Retrospective observational clinical study of 40 eyes (39 patients) with various retinopathies from October 2016 to June 2017 at a tertiary care retina clinic in NYC. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002433DOI Listing
February 2019

Branch retinal vein occlusion associated with platelet activation

Turk J Med Sci 2019 Feb 11;49(1):283-287. Epub 2019 Feb 11.

Background/aim: The aim of this study is to study subclinical platelet activation by detecting three important platelet activation parameters of mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in patients with branch retinal vein occlusion (BRVO) in comparison to those in healthy control subjects.

Materials And Methods: This prospective study included 43 patients with BRVO (Group 1)and 40 control subjects (Group 2). The levels of MPV, PDW, and PCT were measured in both of the studied groups

Results: The mean serum level of MPV value was 7. Read More

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http://dx.doi.org/10.3906/sag-1807-223DOI Listing
February 2019

Needles as a source of silicone oil during intravitreal injection.

Eye (Lond) 2019 Feb 13. Epub 2019 Feb 13.

Federal University of São Paulo, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1038/s41433-019-0365-7DOI Listing
February 2019

Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice.

Int J Mol Sci 2019 Feb 12;20(3). Epub 2019 Feb 12.

First Department of Ophthalmology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.

This study aimed to investigate whether the transplantation of genetically engineered bone marrow-derived mesenchymal stromal cells (MSCs) to overexpress brain-derived neurotrophic factor (BDNF) could rescue the chronic degenerative process of slow retinal degeneration in the rd6 (retinal degeneration 6) mouse model and sought to identify the potential underlying mechanisms. Rd6 mice were subjected to the intravitreal injection of lentivirally modified MSC-BDNF or unmodified MSC or saline. In vivo morphology, electrophysiological retinal function (ERG), and the expression of apoptosis-related genes, as well as BDNF and its receptor (TrkB), were assessed in retinas collected at 28 days and three months after transplantation. Read More

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http://dx.doi.org/10.3390/ijms20030777DOI Listing
February 2019

Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice.

Cell Rep 2019 Feb;26(7):1718-1726.e4

Division of Biotechnology Review and Research-III, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. Electronic address:

Zaire Ebola virus (ZEBOV) survivors experience visual and CNS sequelae that suggests the ZEBOV glycoprotein can mediate neurotropism. Replication-competent rVSVΔG-ZEBOV-GP vaccine candidate is generally well tolerated; however, its potential neurotropism requires careful study. Here, we show that a single inoculation of rVSVΔG-ZEBOV-GP virus in neonatal C57BL/6 mice results in transient viremia, neurological symptoms, high viral titers in eyes and brains, and death. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.069DOI Listing
February 2019

Retinal Microvascular Changes in Microvascular Angina: Findings from the Australian Heart Eye Study.

Microcirculation 2019 Feb 13:e12536. Epub 2019 Feb 13.

Centre for Vision Research, The Westmead Institute for Medical Research, University of Sydney, NSW, Australia.

Objective: Microvascular changes in microvascular angina are poorly understood due to difficulties in imaging the coronary microcirculation in vivo. The retinal microvasculature may reflect changes in coronary microcirculation. We assessed microvascular changes in the retina in patients with microvascular angina and compared them with patients with angiographically proven coronary artery disease. Read More

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http://dx.doi.org/10.1111/micc.12536DOI Listing
February 2019

Fisetin rescues retinal functions by suppressing inflammatory response in a DBA/2J mouse model of glaucoma.

Doc Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, People's Hospital of Rizhao, No. 126 Tai'an Road, Donggang District, Rizhao, 276800, Shandong, China.

Purpose: Glaucoma is a common chronic neurodegenerative disease, which could lead to visual loss. In this study, we aimed to investigate whether fisetin, a natural flavone with anti-inflammatory and antioxidant properties, is able to alleviate glaucoma.

Methods: We employed a DBA/2J mouse model which was treated with or without fisetin. Read More

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http://dx.doi.org/10.1007/s10633-019-09676-9DOI Listing
February 2019

A biophysical model explains the spontaneous bursting behavior in the developing retina.

Sci Rep 2019 Feb 12;9(1):1859. Epub 2019 Feb 12.

Biovision team, Université Côte d'Azur, Inria, France.

During early development, waves of activity propagate across the retina and play a key role in the proper wiring of the early visual system. During a particular phase of the retina development (stage II) these waves are triggered by a transient network of neurons, called Starburst Amacrine Cells (SACs), showing a bursting activity which disappears upon further maturation. The underlying mechanisms of the spontaneous bursting and the transient excitability of immature SACs are not completely clear yet. Read More

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http://dx.doi.org/10.1038/s41598-018-38299-4DOI Listing
February 2019

From 2D to 3D: Strain- and elongation-free topological transformations of optoelectronic circuits.

Proc Natl Acad Sci U S A 2019 Feb 12. Epub 2019 Feb 12.

Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109;

Optoelectronic circuits in 3D shapes with large deformations can offer additional functionalities inaccessible to conventional planar electronics based on 2D geometries constrained by conventional photolithographic patterning processes. A light-sensing focal plane array (FPA) used in imagers is one example of a system that can benefit from fabrication on curved surfaces. By mimicking the hemispherical shape of the retina in the human eye, a hemispherical FPA provides a low-aberration image with a wide field of view. Read More

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http://dx.doi.org/10.1073/pnas.1813001116DOI Listing
February 2019

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.

Sci Signal 2019 Feb 12;12(568). Epub 2019 Feb 12.

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

DNA-alkylating agents are commonly used to kill cancer cells, but the base excision repair (BER) pathway they trigger can also produce toxic intermediates that cause tissue damage, such as retinal degeneration (RD). Apoptosis, a process of programmed cell death, is assumed to be the main mechanism of this alkylation-induced photoreceptor (PR) cell death in RD. Here, we studied the involvement of necroptosis (another programmed cell death process) and inflammation in alkylation-induced RD. Read More

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http://dx.doi.org/10.1126/scisignal.aau9216DOI Listing
February 2019

Evolution of retinal changes measured by optical coherence tomography in the assessment of hydroxychloroquine ocular safety in patients with systemic lupus erythematosus.

Lupus 2019 Feb 12:961203319829826. Epub 2019 Feb 12.

1 Autoimmune Diseases Research Unit, Department of Internal Medicine, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, University of The Basque Country, Bizkaia, Basque Country, Spain.

Objective: The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces cohort treated with hydroxychloroquine (HCQ).

Methods: SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer thickness (GCLT) and qualitative data of retinal pigment epithelium (RPE) and external retina (ExtR) were collected prospectively. Read More

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http://dx.doi.org/10.1177/0961203319829826DOI Listing
February 2019

Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?

Int J Mol Sci 2019 Feb 11;20(3). Epub 2019 Feb 11.

. Department of Therapeutics, Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012 Paris, France.

The retinal pigment epithelium (RPE) forms the outer blood⁻retina barrier and facilitates the transepithelial transport of glucose into the outer retina via GLUT1. Glucose is metabolized in photoreceptors via the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS) but also by aerobic glycolysis to generate glycerol for the synthesis of phospholipids for the renewal of their outer segments. Aerobic glycolysis in the photoreceptors also leads to a high rate of production of lactate which is transported out of the subretinal space to the choroidal circulation by the RPE. Read More

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http://dx.doi.org/10.3390/ijms20030762DOI Listing
February 2019

Concise Review: Update on Retinal Pigment Epithelium Transplantation for Age-Related Macular Degeneration.

Stem Cells Transl Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmacology, Physiology, and Neuroscience, Rutgers-New Jersey Medical School, Newark, New Jersey, USA.

Retinal cell therapy can have the objectives of rescue (i.e., modulation of metabolic abnormalities primarily for sight preservation) as well as replacement (i. Read More

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http://dx.doi.org/10.1002/sctm.18-0282DOI Listing
February 2019

Scotopic contour and shape discrimination using radial frequency patterns.

J Vis 2019 Feb;19(2)

Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Radial frequency (RF) patterns are valuable tools for investigations of contour integration and shape discrimination. Under photopic conditions, healthy observers can detect deformations from circularity in RF patterns as small as 3 seconds of arc. Such fine discrimination may be facilitated by cortical curvature detectors or global shape-detecting mechanisms that favor a closed contour. Read More

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http://jov.arvojournals.org/article.aspx?doi=10.1167/19.2.7
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http://dx.doi.org/10.1167/19.2.7DOI Listing
February 2019
1 Read

Novel Findings of Polypoidal Choroidal Vasculopathy via Optical Coherence Tomography Angiography.

Korean J Ophthalmol 2019 Feb;33(1):54-62

Department of Ophthalmology, Nune Eye Hospital, Seoul, Korea.

Purpose: To introduce novel findings of polypoidal choroidal vasculopathy (PCV) via optical coherence tomography angiography (OCTA).

Methods: This study is a retrospective chart review of 16 patients (16 eyes) with PCV. OCTA (Avanti RTVue XR) findings were evaluated and selected for analysis after agreement by two retina specialists . Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2018.00
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http://dx.doi.org/10.3341/kjo.2018.0048DOI Listing
February 2019
1 Read

Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales.

Retinoid X receptors (RXRs) belong to the nuclear receptor superfamily, and upon ligand activation, these receptors control gene transcription via either homodimerization with themselves or heterodimerization with the partner-nuclear receptor. The protective effects of RXRs and RXR agonists have been reported in several neurodegenerative diseases, including in the retina. This study was aimed to prioritize compounds from natural and synthetic origin retinoids as potential RXR agonists by molecular docking and molecular dynamic simulation strategies. Read More

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http://dx.doi.org/10.1002/jcb.28455DOI Listing
February 2019

Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue.

J Med Imaging (Bellingham) 2019 Jan 29;6(1):014002. Epub 2019 Jan 29.

University of Arizona, College of Optical Sciences, Tucson, Arizona, United States.

Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Read More

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http://dx.doi.org/10.1117/1.JMI.6.1.014002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350616PMC
January 2019

Intranasal administration of erythropoietin rescues the photoreceptors in degenerative retina: a noninvasive method to deliver drugs to the eye.

Drug Deliv 2019 Dec;26(1):78-88

f Department of Neurosurgery and Institute for Functional Brain Disorders , Tangdu Hospital Fourth Military Medical University , Xi'an , PR China.

Inherited retinopathies typically lead to photoreceptor loss and severe visual impairments in the subjects. Intranasal administration is an efficient approach to deliver therapeutic agents to the targeted tissue. The present study is designed to deliver the erythropoietin (EPO) into the N-methyl-N-nitrosourea (MNU) induced mice, a pharmacological retinopathy model via intranasal or intravenous route. Read More

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http://dx.doi.org/10.1080/10717544.2018.1556361DOI Listing
December 2019

Angiopoietin-2 Inhibition Rescues Arteriovenous Malformation in a Smad4 Hereditary Hemorrhagic Telangiectasia Mouse Model.

Circulation 2019 Feb 12. Epub 2019 Feb 12.

Molecular Biology, Tulane University, New Orleans, LA.

Background: Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder caused by heterozygous, loss-of-function mutations in four TGFβ pathway members, including the central transcriptional mediator of the TGFβ pathway, Smad4. Loss of Smad4 causes the formation of inappropriate, fragile connections between arteries and veins called arteriovenous malformations (AVM), which can hemorrhage leading to stroke, aneurysm or death. Unfortunately, the molecular mechanisms underlying AVM pathogenesis remain poorly understood and the TGFβ downstream effectors responsible for HHT-associated AVM formation are currently unknown. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036952DOI Listing
February 2019

An Approach to Automatic Hard Exudate Detection in Retina Color Images by a Telemedicine System Based on the d-Eye Sensor and Image Processing Algorithms.

Sensors (Basel) 2019 Feb 8;19(3). Epub 2019 Feb 8.

Department of Ophthalmology, Faculty of Medicine, Medical University of Bialystok, 24A Curie-Sklodowskiej Street, 15-276 Bialystok, Poland.

Hard exudates are one of the most characteristic and dangerous signs of diabetic retinopathy. They can be marked during the routine ophthalmological examination and seen in color fundus photographs (i.e. Read More

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http://dx.doi.org/10.3390/s19030695DOI Listing
February 2019

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2.

Free Radic Biol Med 2019 Feb 8. Epub 2019 Feb 8.

Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA; Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, USA. Electronic address:

Sigma 1 receptor (Sig1R), a putative molecular chaperone, has emerged as a novel therapeutic target for retinal degenerative disease. Earlier studies showed that activation of Sig1R via the high-affinity ligand (+)-pentazocine ((+)-PTZ) induced profound rescue of cone photoreceptor cells in the rd10 mouse model of retinitis pigmentosa; however the mechanism of rescue is unknown. Improved cone function in (+)-PTZ-treated mice was accompanied by reduced oxidative stress and normalization of levels of NRF2, a transcription factor that activates antioxidant response elements (AREs) of hundreds of cytoprotective genes. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.001DOI Listing
February 2019

Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina.

FASEB J 2019 Feb 11:fj201802144R. Epub 2019 Feb 11.

Fight Against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul National University, Seoul, South Korea.

Ischemic retinopathies and optic neuropathies are important causes of vision loss. The neuroprotective effect of erythropoietin (EPO) in ischemic neuronal injury and the expression of EPO and its receptor in retinal tissue have been well documented. However, the exact regulatory mechanism of EPO expression in retinal ischemia still remains to be elucidated. Read More

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http://dx.doi.org/10.1096/fj.201802144RDOI Listing
February 2019

Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration.

Nat Genet 2019 Feb 11. Epub 2019 Feb 11.

Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Genome-wide association studies (GWAS) have identified genetic variants at 34 loci contributing to age-related macular degeneration (AMD). We generated transcriptional profiles of postmortem retinas from 453 controls and cases at distinct stages of AMD and integrated retinal transcriptomes, covering 13,662 protein-coding and 1,462 noncoding genes, with genotypes at more than 9 million common SNPs for expression quantitative trait loci (eQTL) analysis of a tissue not included in Genotype-Tissue Expression (GTEx) and other large datasets. Cis-eQTL analysis identified 10,474 genes under genetic regulation, including 4,541 eQTLs detected only in the retina. Read More

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http://dx.doi.org/10.1038/s41588-019-0351-9DOI Listing
February 2019
29.352 Impact Factor

LONGITUDINAL CHANGES IN EYES WITH HYDROXYCHLOROQUINE RETINAL TOXICITY.

Retina 2019 Feb 5. Epub 2019 Feb 5.

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

Purpose: To characterize functional and structural changes in hydroxychloroquine (HCQ) retinal toxicity after drug cessation.

Methods: Twenty-two patients (91% female; mean age 58.7 ± 11. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002437DOI Listing
February 2019

Scleral buckling versus vitrectomy for young japanese patients with rhegmatogenous retinal detachment in the era of microincision surgery: real-world evidence from a multicentre study in Japan.

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan.

Purpose: To evaluate real-world evidence for young Japanese patients with rhegmatogenous retinal detachment (RRD) by retrospectively examining surgical procedures and clinical outcomes in the Japan Clinical Retina Study group.

Methods: This was a multicentre retrospective study of the medical records of 562 young patients (384 males and 178 females; mean age: 33.0 ± 11. Read More

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http://dx.doi.org/10.1111/aos.14050DOI Listing
February 2019

Subconjunctival Orbital Fat Prolapse: An Update on Diagnosis and Management.

Semin Ophthalmol 2019 Feb 9:1-5. Epub 2019 Feb 9.

c Oculoplastic Department , Institut Català de Retina , Barcelona , España.

Subconjunctival prolapse of orbital fat is an uncommon clinical entity in which intraconal orbital fat herniates into the subconjunctival space. Its diagnosis is mainly clinical in character and usually based on palpation, patient clinical history, and lesion features along with a slit lamp examination. Its pathophysiology remains unclear. Read More

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http://dx.doi.org/10.1080/08820538.2019.1576743DOI Listing
February 2019

Long-term outcomes of switching to aflibercept for treatment-resistant neovascular age-related macular degeneration.

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Sydney Retina Clinic & Day Surgery, Sydney, NSW, Australia.

Purpose: To report 4-year outcomes following the switch to aflibercept in treatment-resistant neovascular age-related macular degeneration (nAMD).

Methods: In this prospective, open-label, non-controlled, clinical trial, 49 patients with treatment-resistant nAMD received 2 mg intravitreal aflibercept as three loading doses every 4 weeks, followed by injections every 8 weeks for the first 48 weeks, then an individualized regimen for a further 36 months, following previous treatment with ranibizumab and/or bevacizumab. Outcome measures included best-corrected visual acuity (BCVA), central retinal thickness (CRT), pigment epithelial detachment (PED) height and geographic atrophy (GA) surface area. Read More

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http://dx.doi.org/10.1111/aos.14046DOI Listing
February 2019

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids.

Biomaterials 2019 Jan 22;199:63-75. Epub 2019 Jan 22.

Institute of Genetic Medicine, Newcastle University, UK. Electronic address:

Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation. To mimic this phenomenon in vitro, tissue decellularisation approaches have been developed, resulting in the generation of natural ECM scaffolds that have comparable physical and biochemical properties of the natural tissues and are currently gaining traction in tissue engineering and regenerative therapies due to the ease of standardised production, and constant availability. In this manuscript we report the successful generation of decellularised ECM-derived peptides from neural retina (decel NR) and retinal pigment epithelium (decel RPE), and their impact on differentiation of human pluripotent stem cells (hPSCs) to retinal organoids. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.028DOI Listing
January 2019

Abdominal obesity linked to a longer cone-mediated dark-adaptation recovery time in healthy eyes.

Exp Eye Res 2019 Feb 6;181:163-170. Epub 2019 Feb 6.

Applied Optics Complutense Group, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Av. Arcos de Jalón 118, Madrid, 28037, Spain.

Obesity has been associated with abnormal lipid metabolism and with tissue hypoxia. Human Bruch's membrane (BrM) lipid deposits have been proposed to create a diffusion barrier to metabolic exchange between the choroid and photoreceptors, delaying the regeneration of photopigments. The speed of retinal dark adaptation (DA) is dependent on the regeneration of these photopigments. Read More

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http://dx.doi.org/10.1016/j.exer.2019.02.007DOI Listing
February 2019

Rod photoresponse kinetics limit temporal contrast sensitivity in mesopic vision.

J Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Center for Vision Research, Department of Ophthalmology, SUNY Upstate Medical University, Syracuse, New York, USA

The mammalian visual system operates over an extended range of ambient light levels by switching between rod and cone photoreceptors. Rod-driven vision is sluggish, highly sensitive and operates in dim or scotopic lights while cone-driven vision is brisk, less sensitive and operates in bright or photopic lights. At intermediate or mesopic lights, vision transitions seamlessly from rod-driven to cone-driven, despite the profound differences in rod and cone response dynamics. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1404-18.2019DOI Listing
February 2019

Linkage between retinal ganglion cell density and the nonuniform spatial integration across the visual field.

Proc Natl Acad Sci U S A 2019 Feb 8. Epub 2019 Feb 8.

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL 35294.

The ability to integrate visual information over space is a fundamental component of human pattern vision. Regardless of whether it is for detecting luminance contrast or for recognizing objects in a cluttered scene, the position of the target in the visual field governs the size of a window within which visual information is integrated. Here we analyze the relationship between the topographic distribution of ganglion cell density and the nonuniform spatial integration across the visual field. Read More

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http://dx.doi.org/10.1073/pnas.1817076116DOI Listing
February 2019

[Retinovascular Findings in Susac's Syndrome].

Laryngorhinootologie 2019 Feb 8;98(2):108-113. Epub 2019 Feb 8.

Background: Susac syndrome is a vasculopathy affecting the central nervous system, retina and cochlea leading to the triad encephalopathy, branch retinal artery occlusions and hearing loss. To date, about 300 cases have been described in the literature.

Patients/methods: Three patients with confirmed Susac syndrome were evaluated for disease-specific retinal pathologies. Read More

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http://dx.doi.org/10.1055/a-0747-6968DOI Listing
February 2019

Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.

Free Radic Biol Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Cell Biology, Taizhou University, Taizhou, PR China. Electronic address:

Hydrogen possesses antioxidative effects and cures numerous types of ophthalmopathy, but the mechanism of hydrogen on ROS-induced retinal senescence remains elusive. In this study, retinal morphology revealed that hydrogen reduced the number and size of vitreous black deposits in Bruch's membrane in NaIO3 mice. Hydrogen also reduced ROS levels in the retina as assessed by DHE staining. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.005DOI Listing
February 2019
5.736 Impact Factor

A lambda-shaped retractor lentis muscle in the yellowfin goby Acanthogobius flavimanus.

J Morphol 2019 Feb 8. Epub 2019 Feb 8.

Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan.

We identified a morphologically uncommon piscine retractor lentis muscle in the yellowfin goby Acanthogobius flavimanus. This lentis muscle has a shape similar to the Greek small letter lambda (λ). The two legs of the muscle are attached to the retinal periphery at the ventral eyecup, while the tip is connected to the lens surface by a ligament. Read More

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http://doi.wiley.com/10.1002/jmor.20961
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http://dx.doi.org/10.1002/jmor.20961DOI Listing
February 2019
1 Read

Estimating Retinal Sensitivity Using Optical Coherence Tomography With Deep-Learning Algorithms in Macular Telangiectasia Type 2.

JAMA Netw Open 2019 Feb 1;2(2):e188029. Epub 2019 Feb 1.

Department of Ophthalmology, University of Washington, Seattle.

Importance: As currently used, microperimetry is a burdensome clinical testing modality for testing retinal sensitivity requiring long testing times and trained technicians.

Objective: To create a deep-learning network that could directly estimate function from structure de novo to provide an en face high-resolution map of estimated retinal sensitivity.

Design, Setting, And Participants: A cross-sectional imaging study using data collected between January 1, 2016, and November 30, 2017, from the Natural History Observation and Registry of macular telangiectasia type 2 (MacTel) evaluated 38 participants with confirmed MacTel from 2 centers. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.8029DOI Listing
February 2019

Structure and function of the bird fovea.

Anat Histol Embryol 2019 Feb 7. Epub 2019 Feb 7.

Department of Ophthalmology and Eye Hospital, Medical Faculty, University of Leipzig, Leipzig, Germany.

The cellular structure and functional relevance of the bird fovea are still incompletely understood. This review gives an overview of the cellular composition of the bird fovea, with special regard to Müller glial cells that provide the mechanical stability of the foveal tissue. A survey of previous data shows that the visual acuity of different bird groups (with the exception of owls) depends on the eye size, while the shape of the foveal pit does not correlate with the visual acuity. Read More

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http://dx.doi.org/10.1111/ahe.12432DOI Listing
February 2019

Transcriptome profiling of zebrafish optic fissure fusion.

Sci Rep 2019 Feb 7;9(1):1541. Epub 2019 Feb 7.

Development, Ageing and Disease, UCL Institute of Ophthalmology, London, UK.

Incomplete fusion of the optic fissure leads to ocular coloboma, a congenital eye defect that affects up to 7.5 per 10,000 births and accounts for up to 10 percent of childhood blindness. The molecular and cellular mechanisms that facilitate optic fissure fusion remain elusive. Read More

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http://dx.doi.org/10.1038/s41598-018-38379-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367446PMC
February 2019
1 Read

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in retina.

J Biol Chem 2019 Feb 7. Epub 2019 Feb 7.

Penn State College of Medicine, United States.

Diabetes promotes the post-translational modification of proteins by O-linked addition of N-acetylglucosamine (O-GlcNAcylation) to Ser/Thr residues of proteins and thereby contributes to diabetic complications. In the retina of diabetic mice, the repressor of mRNA translation eIF4E-binding protein 1 (4E-BP1) is O-GlcNAcylated and sequestration of the cap-binding protein eukaryotic translation initiation factor (eIF4E) is enhanced. O-GlcNAcylation has also been detected on several eukaryotic translation initiation factors and ribosomal proteins. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007494DOI Listing
February 2019

Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina.

J Neuroinflammation 2019 Feb 7;16(1):26. Epub 2019 Feb 7.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, 50931, Cologne, Germany.

Background: Age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly. The neovascular (wet) form of AMD can be treated with intravitreal injections of different anti-vascular endothelial growth factor (VEGF) agents. Placental growth factor (PGF) is another member of the VEGF family of cytokines with pro-angiogenic and pro-inflammatory effects. Read More

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http://dx.doi.org/10.1186/s12974-019-1419-2DOI Listing
February 2019
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Multimodal imaging of torpedo maculopathy including adaptive optics.

Eur J Ophthalmol 2019 Feb 8:1120672119827772. Epub 2019 Feb 8.

3 Aix Marseille Université, CNRS, Institut Neurosciences Timone (INT), Marseille, France.

Purpose:: The etiology of torpedo maculopathy remains unknown, but it has been recently suggested that it could represent a persistent defect in the development of the retinal pigment epithelium. As retinal pigment epithelium and photoreceptors form a functional unit, an alteration of photoreceptor distribution or function is predictable. The aim of this study is to describe multimodal imaging, including adaptive optics, in three cases of torpedo maculopathy, and discuss its pathogenesis. Read More

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http://dx.doi.org/10.1177/1120672119827772DOI Listing
February 2019

Observation of changes after peripheral retinal injury by cosmetic laser, using wide-field scanning laser ophthalmoscope: A case report.

Authors:
Rae Young Kim Ho Ra

Medicine (Baltimore) 2019 Feb;98(6):e14354

Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Rationale: Increases in cosmetic laser use have led to recent reports of accidental retinal injuries, most of which are limited to the posterior pole. We report a case of peripheral retinal injury caused by a 1064-nm Nd:YAG: neodymium-doped yttrium aluminum garnet.

Patient Concerns: A 27-year-old Asian woman was admitted with scotoma symptoms in her right eye. Read More

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http://dx.doi.org/10.1097/MD.0000000000014354DOI Listing
February 2019

Müller cells as a target for retinal therapy.

Drug Discov Today 2019 Feb 4. Epub 2019 Feb 4.

Ghent Research Group on Nanomedicines, Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Electronic address:

Müller cells are specialized glial cells that span the entire retina from the vitreous cavity to the subretinal space. Their functional diversity and unique radial morphology render them particularly interesting targets for new therapeutic approaches. In this review, we reflect on various possibilities for selective Müller cell targeting and describe how some of their cellular mechanisms can be used for retinal neuroprotection. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.01.023DOI Listing
February 2019

Impact of automated OCT in a high-volume eye urgent care setting.

BMJ Open Ophthalmol 2019 20;4(1):e000187. Epub 2019 Jan 20.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mt. Sinai, New York City, New York, USA.

Background/aims: Optical coherence tomography (OCT) has become standard of care in the diagnosis and management of a myriad of retinal and optic nerve pathology. Access to diagnostic equipment and skilled imaging personnel in the after-hours setting is often limited. We examined the utility and diagnostic indications for automated OCT in a high-volume after-hours clinic within an eye institute. Read More

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http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
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http://dx.doi.org/10.1136/bmjophth-2018-000187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340595PMC
January 2019
2 Reads

Anterior elongation of the retina in persistent fetal vasculature: emphasis on retinal complications.

Eye (Lond) 2019 Feb 6. Epub 2019 Feb 6.

Gazi University School of Medicine, Ankara, 06500, Turkey.

Purpose: To identify the characteristics of peripheral retinal anomalies associated with persistent fetal vasculature (PFV) and evaluate the complications and outcomes.

Methods: Retrospective, noncomparative case series of patients with PFV who underwent surgery. Type of PFV, presence of peripheral retinal anomalies, extent of the retrolental membrane, complications, and functional and anatomical results were evaluated. Read More

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http://dx.doi.org/10.1038/s41433-019-0345-yDOI Listing
February 2019
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Retinal and choroidal thickness in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome.

BMC Ophthalmol 2019 Feb 6;19(1):44. Epub 2019 Feb 6.

Department of Ophthalmology, Peking University Frist Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: A study was conducted to evaluate the choroidal thickness (CT) and retinal thickness (RT) in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome (NS). We also studied the correlation between the subfoveal choroidal thickness (SFCT) and serum protein concentration.

Methods: This was a cross-sectional study. Read More

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http://dx.doi.org/10.1186/s12886-019-1050-0DOI Listing
February 2019
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[Highlights in the field of ophthalmology].

Rev Med Suisse 2019 Feb;15(637):355-357

Hôpital ophtalmique Jules-Gonin, Université de Lausanne, Fondation Asile des Aveugles, Avenue de France 15, 1000 Lausanne 7.

Technological advances in ophthalmology are becoming more and more important. New imaging instruments and software analysis allow ultra-wide field visualization of the retina non-invasively. This creates important clinical advantages for an aging population affected by chronic pathologies such as cataract, age related macular degeneration, and diabetic retinopathy. Read More

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February 2019
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