165,493 results match your criteria Retina Philadelphia Pa.[Journal]


Adherence to Optical Safety Guidelines for Laser-Assisted Hair Removal.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: In recent years, there was a rise in ocular injuries secondary to cosmetic laser-assisted hair removal.

Purpose: To assess the level of adherence to optical safety guidelines during laser-assisted hair removal performed by nurses or physicians in private practice.

Methods: A cross-sectional study was conducted at thirty-one private laser-assisted hair removal clinics. Read More

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http://dx.doi.org/10.1111/phpp.12473DOI Listing

Comparison between refractive outcomes between macula-on and macula-off retinal detachments after phaco-vitrectomy.

Jpn J Ophthalmol 2019 Apr 20. Epub 2019 Apr 20.

Department of Ophthalmology, School of Medicine, Pusan National University, Busan, South Korea.

Purpose: To evaluate axial length (AL) measurements and refractive outcomes in vitrectomy combined with cataract operation for rhegmatogenous retinal detachment (RRD) with wholly detached macula.

Study Design: Retrospective, consecutive, comparative, clinical study.

Methods: We reviewed the data of patients treated by vitrectomy combined with cataract operation for RRD. Read More

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http://dx.doi.org/10.1007/s10384-019-00667-6DOI Listing

Sectoral Choroidal Hypopigmentation.

Ophthalmology 2019 May;126(5):711

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.ophtha.2019.02.020DOI Listing

Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography.

J AAPOS 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, Sıtkı Kocman University, Mugla, Turkey.

Purpose: To investigate retinal microvascular findings detected by optical coherence tomography angiography (OCT-A) in amblyopic eyes compared with normal eyes.

Methods: A total of 23 amblyopic (strabismic, ametropic, anisometropic, and meridional amblyopia) and 22 normal eyes were included in this prospective observational, comparative study. All patients underwent complete ophthalmological examination and OCT-A imaging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10918531193008
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http://dx.doi.org/10.1016/j.jaapos.2018.12.009DOI Listing
April 2019
1 Read

Retinal Vessel Phenotype in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy.

Am J Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of ophthalmology, University Hospital of Grenoble-Alpes, France; Grenoble-Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France; Department of Ophthalmology, University Hospital of Grenoble-Alpes, Grenoble, France. Electronic address:

Purpose: The pathophysiology of non-arteritic AION (N-AION) is not completely understood. Studies of the retinal vasculature phenotype in patients with N-AION could help us to understand vascular abnormalities associated with the disease.

Design: Retrospective case series with matched controls. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.007DOI Listing

Outcomes after Epiretinal Membrane Surgery with or Without Internal Limiting Membrane Peeling.

Ophthalmol Ther 2019 Apr 19. Epub 2019 Apr 19.

Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Introduction: The aim of this study was to assess the incidence of persistent postoperative cystoid macular edema (pCME) in patients undergoing pars plana vitrectomy with epiretinal membrane peel (ERM) only versus those with ERM peel combined with internal limiting membrane peel (ILM). Secondary endpoints of the study were to review both the central macular thickness (CMT) and visual acuity.

Methods: The patients were divided in two groups, one group in which only the ERM was peeled (n = 36 patients) and another group in which both the ERM and the ILM were removed (n = 62 patients). Read More

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http://link.springer.com/10.1007/s40123-019-0185-7
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http://dx.doi.org/10.1007/s40123-019-0185-7DOI Listing
April 2019
1 Read

Contact Lens Based Drug Delivery to the Posterior Segment Via Iontophoresis in Cadaver Rabbit Eyes.

Pharm Res 2019 Apr 19;36(6):87. Epub 2019 Apr 19.

Department of Chemical Engineering, University of Florida, 1030 Center Drive, Gainesville, Florida, 32611, USA.

Purpose: A drug loaded contact lens combined with electrodes positioned diametrically opposite and beyond the limbus can potentially deliver ionic drugs directly to the vitreous.

Methods: Commercial lenses are loaded with nile blue or fluorescein as the drug analogs and placed on cadaver rabbit eyes. Electrodes (19. Read More

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http://link.springer.com/10.1007/s11095-019-2625-4
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http://dx.doi.org/10.1007/s11095-019-2625-4DOI Listing
April 2019
1 Read

Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study.

Sci Rep 2019 Apr 19;9(1):6320. Epub 2019 Apr 19.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.

Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyperintensities [WMH] on structural MRI, visual scores and volume; perivascular spaces; lacunes and microbleeds), and vascular risk measures were assessed in both cohorts. Read More

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http://www.nature.com/articles/s41598-019-42534-x
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http://dx.doi.org/10.1038/s41598-019-42534-xDOI Listing
April 2019
1 Read

A modified intraocular lens design to reduce negative dysphotopsia.

J Cataract Refract Surg 2019 Apr 16. Epub 2019 Apr 16.

retired, Orange, California, USA.

Purpose: To use ray-tracing analysis and simulated retinal illumination profiles to design an intraocular lens (IOL) that prevents or reduces negative dysphotopsia after cataract surgery.

Setting: Mayo Clinic, Rochester, Minnesota, and Simpson Optics LLC, Arlington, Texas, USA.

Design: Experimental study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08863350193004
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http://dx.doi.org/10.1016/j.jcrs.2019.01.019DOI Listing
April 2019
1 Read

Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):47-50

Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Type 2 diabetes mellitus (T2DM) is the most common metabolic and multifactorial disease in which both genetic and environmental factors are involved. In diabetes, the defects in the cellular metabolism result in higher levels of free radicals. These radicals react with other vital cellular molecules, which are responsible in diabetes side effects and known as diabetic retinopathy (DR), a disease of the retina that results in impairment or loss of vision. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2019025074DOI Listing
January 2019

The circadian clock gene is required to control the timing of retinal neurogenesis and lamination of Müller glia in the mouse retina.

FASEB J 2019 Apr 19:fj201801832RR. Epub 2019 Apr 19.

Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

A single pool of multipotent retinal progenitor cells give rise to the diverse cell types within the mammalian retina. Such cellular diversity is due to precise control of various cellular processes like cell specification, proliferation, differentiation, and maturation. Circadian clock genes can control the expression of key regulators of cell cycle progression and therefore can synchronize the cell cycle state of a heterogeneous population of cells. Read More

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http://dx.doi.org/10.1096/fj.201801832RRDOI Listing

Growth and survival of Takifugu rubripes larvae cultured under different light conditions.

Fish Physiol Biochem 2019 Apr 19. Epub 2019 Apr 19.

College of Marine Science and Environment Engineering, Dalian Ocean University, No. 52 Heishijiao Street, Shahekou District, Dalian, 116023, China.

We assessed the effects of light intensity and spectrum on the growth and survival of Takifugu rubripes larvae from 30 to 69 days after hatching. Five lighting regimes were applied using 0.5, 1. Read More

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http://link.springer.com/10.1007/s10695-019-00639-0
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http://dx.doi.org/10.1007/s10695-019-00639-0DOI Listing
April 2019
1 Read

Correlation of retinal vascular perfusion density with dark adaptation in diabetic retinopathy.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, National Taiwan University Hospital, No. 7, Chun-Shan S. Rd., Taipei City, 100, Taiwan.

Purpose: To evaluate the anatomic versus functional changes in diabetic retinopathy (DR) by studying the correlation of retinal vascular perfusion density and dark adaptation (DA).

Methods: Optical coherence tomography angiography (OCTA) and DA tests were performed in diabetic patients and nondiabetic controls. DA was measured using AdaptDx dark adaptometer and the rod intercept was recorded. Read More

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http://link.springer.com/10.1007/s00417-019-04321-2
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http://dx.doi.org/10.1007/s00417-019-04321-2DOI Listing
April 2019
1 Read

Elevated Plasma Levels of Drebrin in Glaucoma Patients With Neurodegeneration.

Front Neurosci 2019 3;13:326. Epub 2019 Apr 3.

State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Aberrations in several cytoskeletal proteins, such as tau have been implicated in the pathogenesis of neurodegenerative diseases, could be initiating factors in glaucoma progression and occurring prior to axon degeneration. Developmentally regulated brain protein (Drebrin or DBN1) is an evolutionarily conserved actin-binding protein playing a prominent role in neurons and is implicated in neurodegenerative diseases. Read More

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http://dx.doi.org/10.3389/fnins.2019.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456690PMC

Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI).

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose: The objective of the study was to assess a new technology, the tear film imager (TFI), which can dynamically image the muco-aqueous and lipid layers.

Methods: Prospective pilot case series of individuals with and without dry eye (DE). Two sequential images were obtained with the TFI. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313379DOI Listing

Comorbidity of dementia and age-related macular degeneration calls for clinical awareness: a meta-analysis.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China

Aim: To determine the association between dementia and age-related macular degeneration (AMD) using meta-analysis.

Methods: We searched in the MEDLINE, EMBASE, Web of Knowledge, PsycInfo and Cochrane database of systematic reviews for studies published from March 1959 to March 2018. We included cross-sectional, case-control and cohort studies that evaluated the association of dementia/Alzheimer's disease (AD) with AMD (as outcome) and the association of AMD with dementia/AD (as outcome). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313277DOI Listing

Anatomical and functional changes in neovascular AMD in remission: comparison of fibrocellular and fibrovascular phenotypes.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, University Vita Salute, Hospital San Raffaele, Milano, Italy

Purpose: To investigate the anatomical changes and the macular function in neovascular age-related macular degeneration (AMD) eyes, according to the recognition of either fibrocellular or fibrovascular phenotype.

Methods: We enrolled eyes with previously treated neovascular AMD in remission (no subretinal haemorrhage, sign of fluid in or under the retina and no treatment for at least 6 months). Subjects underwent multimodal imaging assessment and were tested for macular sensitivity using microperimetry. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313685DOI Listing

Is There A Role for Abscisic Acid, A Proven Anti-Inflammatory Agent, in the Treatment of Ischemic Retinopathies?

Antioxidants (Basel) 2019 Apr 17;8(4). Epub 2019 Apr 17.

Universitat Jaume I, Unitat predepartamental de Medicina, Avda/Sos Baynat, S/N, 12071 Castellón de la Plana, Spain.

Ischemic retinopathies (IRs) are the main cause of severe visual impairment and sight loss, and are characterized by loss of blood vessels, accompanied by hypoxia, and neovascularization. Actual therapies, based on anti-vascular endothelial growth factor (VEGF) strategies, antioxidants or anti-inflammatory therapies are only partially effective or show some adverse side effects. Abscisic acid (ABA) is a phytohormone present in vegetables and fruits that can be naturally supplied by the dietary intake and has been previously studied for its benefits to human health. Read More

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https://www.mdpi.com/2076-3921/8/4/104
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http://dx.doi.org/10.3390/antiox8040104DOI Listing
April 2019
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A Novel Racing Array Transducer for Noninvasive Ultrasonic Retinal Stimulation: A Simulation Study.

Sensors (Basel) 2019 Apr 17;19(8). Epub 2019 Apr 17.

Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Neurostimulation has proved to be an effective method for the restoration of visual perception lost due to retinal diseases. However, the clinically available retinal neurostimulation method is based on invasive electrodes, making it a high-cost and high-risk procedure. Recently, ultrasound has been demonstrated to be an effective way to achieve noninvasive neurostimulation. Read More

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https://www.mdpi.com/1424-8220/19/8/1825
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http://dx.doi.org/10.3390/s19081825DOI Listing
April 2019
1 Read

[Clinical Features, Imaging and Treatment of a Symptomatic Vasoproliferative Tumour of the Retina (VPTR)].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):571-574. Epub 2019 Apr 18.

Augenklinik, Universitätsmedizin der Johannes-Gutenberg Universität, Mainz.

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http://dx.doi.org/10.1055/a-0857-6455DOI Listing

[Long-term Follow-up After Cryocoagulation in Preterm Newborns from Northern Greece with Retinopathy of Prematurity: Three Year Results].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):542-546. Epub 2019 Apr 18.

Ophthalmologie, 2. Institut für Augenheilkunde und Ophthalmochirurgie "Ophthalmica", Thessaloniki, Griechenland.

Background: This is a retrospective study of the efficacy of treatment of neonates (NN) with exocryocoagulation retinopathy of prematurity (ROP) with respect to morphology of the retina and visual function.

Materials And Methods: Out of a total of 3103 neonates, 304 (9.8%) had a ROP. Read More

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http://dx.doi.org/10.1055/a-0880-5168DOI Listing

Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

Prog Retin Eye Res 2019 Apr 15. Epub 2019 Apr 15.

University of Iceland, Reykjavik, Iceland.

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. Read More

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http://dx.doi.org/10.1016/j.preteyeres.2019.04.001DOI Listing
April 2019
3 Reads

Functional characterization of CEP250 variant identified in nonsyndromic retinitis pigmentosa.

Hum Mutat 2019 Apr 18. Epub 2019 Apr 18.

Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Retinitis pigmentosa (RP) is the most common manifestation of inherited retinal diseases with high degree of genetic, allelic, and phenotypic heterogeneity. CEP250 encodes the C-Nap1 protein and has been associated with various retinal phenotypes. Here, we report the identification of a mutation (c. Read More

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http://dx.doi.org/10.1002/humu.23759DOI Listing

Presumed Choroidal Granuloma Annulare Mimicking Choroidal Lymphoma.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e128-e132

A 71-year-old white male presented with unilateral trace vitreous cell and hypopigmented choroidal lesions, corresponding to hyporeflective areas on optical coherence tomography (OCT). The lesions grew slowly during a period of 2.5 years, but the patient remained asymptomatic. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
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http://dx.doi.org/10.3928/23258160-20190401-18DOI Listing
April 2019
1 Read

Intraoperative Optical Coherence Tomography Demonstrating Macular Hole Associated With Ruptured Retinal Arterial Macroaneurysm.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e125-e127

A 67-year-old female presented with vitreous hemorrhage and sub-internal limited membrane (ILM) hemorrhage in her right eye associated with ruptured retinal arterial macroaneurysm. During pars plana vitrectomy, intraoperative optical coherence tomography aided in the diagnosis of a small macular hole previously obscured by the sub-ILM hemorrhage. Nonexpansile gas was placed followed by postoperative prone positioning, and the hole closed successfully. Read More

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http://dx.doi.org/10.3928/23258160-20190401-17DOI Listing

Clinical Application of Fluorescein Angiography-Free Navigated Focal Laser Photocoagulation in Central Serous Chorioretinopathy.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e118-e124

Background And Objective: To present clinical application of fluorescein angiography (FA)-free focal laser photocoagulation (FLP) of the leakage point in patients with central serous chorioretinopathy (CSC).

Patients And Methods: A prospective case series included 16 eyes of 16 patients with non-resolved CSC. The leakage point was identified with optical coherence tomography (OCT) as a small single pigment epithelium detachment (PED) localized in the upper half of the neurosensory detachment with an area of photoreceptor outer segments layer thinning above this PED. Read More

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http://dx.doi.org/10.3928/23258160-20190401-16DOI Listing

Higher Vascular Density of the Superficial Retinal Capillary Plexus in Degenerative Lamellar Macular Holes.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e112-e117

Background And Objective: Optical coherence tomography angiography (OCTA) comparison between vessel density in patients with degenerative-subtype lamellar macular hole (LMH) and healthy individuals. Unaffected fellow eyes were also included in the study.

Patients And Methods: This observational, cross-sectional study examined 32 eyes affected by unilateral degenerative-subtype LMH, as well as the 32 fellow eyes of the enrolled population. Read More

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http://dx.doi.org/10.3928/23258160-20190401-15DOI Listing
April 2019
1 Read

Long-Term Course Following Vitreous Surgery for Epiretinal Membrane.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e105-e111

Background And Objective: To follow the long-term course of visual acuity (VA) and central retinal thickness (CRT) over at least a 3-year follow-up after vitreous surgery in patients with epiretinal membrane (ERM).

Patients And Methods: This study examined 43 eyes of patients who underwent 23- or 25-gauge vitreous surgery for ERM.

Results: There was significant improvement of the VA at 3 months after surgery compared with baseline, with the improvements maintained for 5 years (analysis of variance [ANOVA]; P < . Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
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http://dx.doi.org/10.3928/23258160-20190401-14DOI Listing
April 2019
2 Reads

Intravitreal Anti-Vascular Endothelial Growth Factor Injections for Macular Edema Associated With Central Retinal Vein Occlusion in Patients Age 40 Years or Younger.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e96-e104

Background And Objective: To determine the efficacy of anti-vascular endothelial growth factor (VEGF) therapy for macular edema due to central retinal vein occlusion (CRVO) in younger adults.

Patients And Methods: The outcomes of CRVO patients age 40 years or younger with baseline logarithm of the minimum angle of resolution (logMAR) visual acuity (VA) between 1.30 (20/400 Snellen equivalent) and 0. Read More

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http://dx.doi.org/10.3928/23258160-20190401-13DOI Listing

Macular Capillary Perfusion in Chinese Patients With Diabetic Retinopathy Obtained With Optical Coherence Tomography Angiography.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e88-e95

Background And Objective: To compare the macular perfusion in the retina and choroidal layer between control subjects and Chinese patients with diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) and to evaluate the association of OCTA characteristics with the stage of DR.

Patients And Methods: A total of 200 eyes (normal controls = 40; mild non-proliferative diabetic retinopathy [NPDR] = 40; moderate NPDR = 40; severe NPDR = 40; and PDR [proliferative diabetic retinopathy] = 40) underwent OCTA imaging. OCTA parameters were vessel densities in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris, as well as foveal avascular zone (FAZ) area (mm) in the SCP. Read More

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http://dx.doi.org/10.3928/23258160-20190401-12DOI Listing
April 2019
1 Read

Displacement of Submacular Hemorrhage With Subretinal Injection of Recombinant Tissue Plasminogen Activator and Gas Tamponade in the Setting of Myopic Degeneration.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):257-259

Myopic submacular hemorrhage (SMH) usually arises from either a break in Bruch's membrane (lacquer cracks) that damages the underlying choriocapillaris or the development of a choroidal neovascular membrane (CNVM) at the sites of prior lacquer cracks.1,2 In pathologic myopia (PM), axial elongation leads to thinning of the choroid and retinal pigment epithelium, predisposing to rupture of Bruch's membrane.3 If large hemorrhages involving the fovea are left untreated, subretinal hemorrhage and CNVM can cause devastating long-term vision loss due to irreversible retinal atrophy. Read More

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http://dx.doi.org/10.3928/23258160-20190401-11DOI Listing

Microcornea, Posterior Megalolenticonus, Persistent Fetal Vasculature, and Coloboma Syndrome Associated With a New Mutation in ZNF408.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):253-256

The authors report a case of a 6-week-old girl with microphthalmia, posterior lenticonus, persistent fetal vasculature, and coloboma of the right eye, with morning glory disc anomaly and falciform retinal folds of the left eye. Genetic testing revealed a previously unreported mutation (c.1471A>G [p. Read More

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http://dx.doi.org/10.3928/23258160-20190401-10DOI Listing

Exudative Retinal Detachment Following Intravitreal Chemotherapeutic Treatment for Retinoblastoma.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):248-252

A 35-month-old boy was diagnosed with retinoblastoma and underwent combination intra-arterial (IAC) and intravitreal chemotherapy. His course was complicated by anaphylactic reaction to IAC, yet he continued to improve with sustained intravitreal therapy. Eight months into treatment, the affected eye developed exudative retinal detachment, which resolved with sub-Tenon's steroid administration. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
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http://dx.doi.org/10.3928/23258160-20190401-09DOI Listing
April 2019
4 Reads

Exudative Retinal Detachment Following Laser Photocoagulation for Retinopathy of Prematurity: A Rare Complication.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):242-246

Laser photocoagulation remains the standard of care for retinopathy of prematurity (ROP). Rarely, exudative retinal detachment (ERD) has been observed as a complication of laser treatment. The authors present the clinical course of an infant who developed severe, unilateral ERD after bilateral laser photocoagulation at 37 weeks postmenstrual age (PMA) for Type I ROP. Read More

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http://dx.doi.org/10.3928/23258160-20190401-08DOI Listing
April 2019
2 Reads

Spontaneous Hyaloidal Contraction and Complex Retinal Detachment in a Patient With Von Hippel-Lindau Syndrome.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):238-241

The authors present an interventional case report of a patient with von Hippel-Lindau (VHL) syndrome who developed simultaneous exudative and combined tractional, rhegmatogenous, and exudative retinal detachment (RD) in the right and left eyes, respectively, following uneventful cryotherapy application of retinal capillary hemangioblastoma (RCH). After pars plana vitrectomy combined with encircling scleral buckling with radial element placement and silicone oil injection, complete retinal reattachment was achieved. The exudative RD of the fellow eye was managed initially with intense topical corticosteroid treatment and subsequent placement of a radial scleral buckle due to the presence of clinically apparent traction. Read More

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http://dx.doi.org/10.3928/23258160-20190401-07DOI Listing

Iris Root Chandelier Illumination for the Management of Advanced Pediatric Tractional Retinal Detachments.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):235-237

Background And Objective: To describe a safe illumination technique in advanced pediatric tractional retinal detachments.

Patients And Methods: A 50-week-old premature infant with stage 5 retinopathy of prematurity was managed utilizing this technique. The surgical technique is demonstrated using a video. Read More

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http://dx.doi.org/10.3928/23258160-20190401-06DOI Listing

Experimental Evidence Behind Clinical Trial Outcomes in Retinopathy of Prematurity.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):228-234

Treatment of severe retinopathy of prematurity (ROP) has evolved over the last decade. This article reviews recent clinical trials and experimental evidence that supports clinical outcomes and observations, including the efficacy of anti-vascular endothelial growth factor (VEGF) agents in reducing the vascular activity of severe ROP, and the mechanisms behind recurrent stage 3 ROP and plus disease in some infants treated with anti-VEGF agents. Also discussed will be current imaging modalities that link experimental models of ROP with longitudinal human studies and which provide exciting future opportunities to enhance the understanding of pathophysiology of ROP and improve treatments. Read More

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http://dx.doi.org/10.3928/23258160-20190401-05DOI Listing

Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):221-227

Background And Objective: Retinovascular anomalies in the fellow eyes of patients with Coats' disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time.

Patients And Methods: This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats' disease.

Results: Three hundred fifty eyes of 175 patients with Coats' disease were analyzed. Read More

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http://dx.doi.org/10.3928/23258160-20190401-04DOI Listing

Vessel Tortuosity Cutoff Values Using the Modified ROPtool May Predict Need for Treatment in Retinopathy of Prematurity.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):215-220

Background And Objective: To quantify vessel tortuosity among infants with retinopathy of prematurity (ROP).

Patients And Methods: This was a retrospective study including 61 RetCam images from 33 infants. The laser treatment (LT) group included 17 infants who underwent laser for ROP. Read More

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http://dx.doi.org/10.3928/23258160-20190401-03DOI Listing

Long-Term Anatomic and Visual Outcome Following Vitrectomy for Stage 4B and 5 Retinopathy of Prematurity.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):208-214

Background And Objectives: Surgical indications in stages 4B and 5 retinopathy of prematurity (ROP) are not universally accepted. The authors' purpose is to evaluate the long-term anatomic and visual outcomes of vitrectomy for retinal detachment (RD) associated with stages 4B and 5 ROP.

Patients And Methods: Data of patients who consecutively underwent vitrectomy for stages 4B and 5 ROP from 1999 to 2013 were retrospectively reviewed and included grade of retinal attachment and visual acuity (VA) at the last follow-up. Read More

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http://dx.doi.org/10.3928/23258160-20190401-02DOI Listing

Early Diagnosis and Management of Aggressive Posterior Vitreoretinopathy Presenting in Premature Neonates.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):201-207

Background And Objective: Aggressive posterior vitreoretinopathy (APVR) manifests with a broad area of retinal avascularity, progressive neovascularization, and/or tractional retinal detachment during the neonatal period.

Patients And Methods: A multicenter, retrospective, observational, consecutive case series study was performed to evaluate the retinal findings and structural retinal outcomes in patients treated for APVR within the first 3 months of life.

Results: Three premature neonates with a non-retinopathy of prematurity (ROP) APVR identified during routine ROP screening exams exhibited relatively severe, rapidly progressive retinal vascular abnormalities. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
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http://dx.doi.org/10.3928/23258160-20190401-01DOI Listing
April 2019
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Analog Derivatization of Cannabidiol for Improved Ocular Permeation.

J Ocul Pharmacol Ther 2019 Apr 18. Epub 2019 Apr 18.

1 Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, Mississippi.

Cannabidiol (CBD), active component of plant , has anti-inflammatory properties that could potentially help treat diabetic retinopathy-induced pain and inflammation. However, CBD is a lipophilic molecule making its topical delivery to back of the eye challenging. This study aims at improving ocular penetration of CBD by means of analog derivatization. Read More

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https://www.liebertpub.com/doi/10.1089/jop.2018.0141
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http://dx.doi.org/10.1089/jop.2018.0141DOI Listing
April 2019
4 Reads

Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina.

Mol Neurobiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured Müller glia for their response to S1P. Read More

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http://dx.doi.org/10.1007/s12035-019-1599-xDOI Listing

Five-year outcomes of retinal vein occlusion treated with vascular endothelial growth factor inhibitors.

BMJ Open Ophthalmol 2019 29;4(1):e000249. Epub 2019 Mar 29.

Sydney Institute of Vision Science, Sydney, New South Wales, Australia.

Purpose: Report 5-year outcomes of patients receiving anti-vascular endothelial growth factor (VEGF) for the treatment of macular oedema secondary to retinal vein occlusion (RVO.

Methods: Retrospective review of eyes with RVO which initiated anti-VEGF treatment. Data including age, gender, visual acuity (VA) and injection numbers were obtained from medical records. Read More

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http://dx.doi.org/10.1136/bmjophth-2018-000249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440600PMC

New macular findings in individuals with biallelic KLHL7 gene mutation.

BMJ Open Ophthalmol 2019 16;4(1):e000234. Epub 2019 Feb 16.

Department of Paediatric Ophthalmology, Bristol Eye Hospital, Bristol, UK.

Objective: The ubiquitin-proteasome system pathway has been recognised as a crucial cellular mechanism for the proper function of photoreceptor cells. In particular, ubiquitin ligases (E3s) recognise and ubiquitinate specific proteins for degradation. The KLHL7 protein (a BTB-Kelch protein) has been found to play an important role in this process. Read More

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http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
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http://dx.doi.org/10.1136/bmjophth-2018-000234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440596PMC
February 2019
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Estimating the magnitude of diabetes mellitus and diabetic retinopathy in an older age urban population in Pune, western India.

BMJ Open Ophthalmol 2019 28;4(1):e000201. Epub 2019 Feb 28.

Department of Community Ophthalmology, PBMA's H. V. Desai Eye Hospital, Pune, Maharashtra, India.

Objective: To estimate magnitude of diabetes mellitus (DM) and diabetic retinopathy (DR) in a high risk population in Pune, western India.

Methods: DR module in rapid assessment of avoidable blindness (RAAB) survey methodology was used. Sample size of 3527 was calculated based on estimates from previous studies in India. Read More

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http://dx.doi.org/10.1136/bmjophth-2018-000201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440599PMC
February 2019

Systemic pharmacokinetic/pharmacodynamic analysis of intravitreal aflibercept injection in patients with retinal diseases.

BMJ Open Ophthalmol 2019 20;4(1):e000185. Epub 2019 Mar 20.

Bayer Pharma, Berlin, Germany.

Objective: Explore relationships between systemic exposure to intravitreal aflibercept injection (IAI) and systemic pharmacodynamic effects via post hoc analyses of clinical trials of IAI for neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME).

Methods And Analysis: Adults from VGFT-OD-0702.PK (n=6), VGFT-OD-0512 (n= 5), VIEW 2 (n=1204) and VIVID-DME (n=404) studies were included. Read More

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http://dx.doi.org/10.1136/bmjophth-2018-000185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440611PMC

Reliability and reproducibility of a rodent model of choroidal neovascularization based on the subretinal injection of polyethylene glycol.

Mol Vis 2019 18;25:194-203. Epub 2019 Mar 18.

Instituto Universitario de Oftalmobiología Aplicada (IOBA), University of Valladolid, Valladolid, Spain.

Purpose: To evaluate the reliability and reproducibility of a rodent choroidal neovascularization (CNV) model by subretinal injection of polyethylene glycol (PEG).

Methods: C57BL/6 mice were injected subretinally with 2 μl PBS (Gibco, Invitrogen, Paisley, UK; n=14) or PEG (1 mg; n=18). Animals were sacrificed at either 0, 5, 14 or 21 days. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441359PMC
March 2019
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Heterogeneity in the retina.

Authors:
Ioana Visan

Nat Immunol 2019 May;20(5):517

Nature Immunology, .

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http://www.nature.com/articles/s41590-019-0390-5
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http://dx.doi.org/10.1038/s41590-019-0390-5DOI Listing
May 2019
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