163,069 results match your criteria Retina Philadelphia Pa.[Journal]


Neuroinflammation as a target for glaucoma therapy.

Neural Regen Res 2019 Mar;14(3):391-394

Visual Neurophysiology and Neurophthalmology Research Unit, IRCCS G.B. Bietti Foundation, Roma, Italy.

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells and microglia) and the release of a plethora of anti- and pro-inflammatory cytokines, chemokines and reactive oxygen species - has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. Read More

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Assessing photoreceptor structure in patients with traumatic head injury.

BMJ Open Ophthalmol 2018 24;3(1):e000104. Epub 2018 Nov 24.

Department of Ophthalmology and Visual Sciences, University of WI - Madison, Madison, Wisconsin, USA.

Objective: Previous work using adaptive optics scanning light ophthalmoscopy (AOSLO) imaging has shown photoreceptor disruption to be a common finding in head and ocular trauma patients. Here an expanded trauma population was examined using a novel imaging technique, split-detector AOSLO, to assess remnant cone structure in areas with significant disruption on confocal AOSLO imaging and to follow photoreceptor changes longitudinally.

Methods And Analysis: Eight eyes from seven subjects with head and/or ocular trauma underwent imaging with spectral domain optical coherence tomography, confocal AOSLO and split-detector AOSLO to assess foveal and parafoveal photoreceptor structure. Read More

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November 2018

Factors Affecting the Outcome of Scleral Buckling Surgery for Primary Rhegmatogenous Retinal Detachment.

J Ophthalmol 2018 13;2018:9016302. Epub 2018 Nov 13.

MD Ophthalmology Resident, Bharatpur Eye Hospital, Bharatpur-10, 44207 Chitwan, Nepal.

Introduction: Scleral buckle surgery retains a special place in treatment of retinal detachment despite development of new and advanced vitreoretinal surgical techniques. The outcome of any retinal detachment surgery depends on correct selection of patient, type and nature of detachment, and the expertise. This study aims to evaluate various other parameters that determine the outcome of scleral buckle surgery. Read More

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November 2018

Mitochondrial Fission Is Required for Blue Light-Induced Apoptosis and Mitophagy in Retinal Neuronal R28 Cells.

Front Mol Neurosci 2018 27;11:432. Epub 2018 Nov 27.

Research Institute of Ophthalmology and Visual Sciences, Affiliated Eye Hospital of Nanchang University, Nanchang, China.

Light emitting diodes (LEDs) are widely used to provide illumination due to their low energy requirements and high brightness. However, the LED spectrum contains an intense blue light component which is phototoxic to the retina. Recently, it has been reported that blue light may directly impinge on mitochondrial function in retinal ganglion cells (RGCs). Read More

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November 2018

Safety of high-dose intravitreal triamcinolone acetonide as low-cost alternative to anti-vascular endothelial growth factor agents in lower-middle-income countries.

Clin Ophthalmol 2018 26;12:2383-2391. Epub 2018 Nov 26.

Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.

Purpose: The purpose of this study was to evaluate the safety of high-dose intravitreal triamcinolone acetonide (IVTA) as affordable low-cost alternative to anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [anti-VEGF] agents) in lower-middle-income countries.

Patients And Methods: This was a retrospective interventional non-comparative case series. The study recruited patients who received 20 mg IVTA for treating various retinal and optic nerve diseases over the past 5 years. Read More

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November 2018

A Novel Variant of the FZD4 Gene in a Chinese Family Causes Autosomal Dominant Familial Exudative Vitreoretinopathy.

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

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December 2018
2 Reads

Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle-aged Caucasians: the Northern Finland Birth Cohort Eye study.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle-aged Caucasians.

Methods: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi-automated computer-assisted program. Read More

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December 2018
1 Read

Induction of CRMP-2 phosphorylation by CDK5 restricts the repair of damaged optic nerve.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.

Objective: To study the mechanism of collapsin response mediator protein-2 (CRMP-2) phosphorylation changes and cyclin-dependent kinase 5 (CDK5) expression after optic nerve injury.

Methods: Optic nerve injury rat models were constructed, the messenger RNA (mRNA) level of CRMP-2 in optic nerve tissues was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) after building models 0, 3, 7, and 14 days. The protein expression of CRMP-2, phospho-CRMP-2 (p-CRMP-2), and CDK5 were also determined by western blot analysis. Read More

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December 2018

Vitreous Wiping, a new technique for removal of vitreous cortex remnants during vitrectomy.

Acta Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: Unremoved vitreoschisis-induced vitreous cortex remnants (VCR) are associated with macular pathology. When present on the retinal periphery, they may play a role in proliferative vitreoretinopathy and retinal detachment after vitrectomy. Existing instruments for their removal involve substantial risk of iatrogenic retinal damage. Read More

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December 2018

Prenatal development of retina in buffalo (Bubalus bubalis).

Anat Histol Embryol 2018 Dec 10. Epub 2018 Dec 10.

Department of Veterinary Anatomy, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana, India.

The development of retina in Indian buffalo (Bubalus bubalis) has not been reported previously. The aim of the present study was therefore to report the major landmarks and the time course in the development of retina. Serial histological sections of Indian buffalo embryos and foetuses were used as group1 (<20. Read More

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December 2018
3 Reads

[Pathophysiology of the glutamate and the glycine transporters: new therapeutic targets].

Rev Neurol 2018 Dec;67(12):491-504

Centro de Biologia Molecular Severo Ochoa. Universidad Autonoma de Madrid, Madrid, Espana.

Introduction: The amino acids glutamate and glycine, apart from their role in protein synthesis, are two fundamental neurotransmitters in the central nervous system of mammals. The first one is ubiquitous and is involved in excitatory pathways of the neocortex, the retina and the cerebellum, and the second is involved in inhibitory pathways of brain caudal areas. However, both share their way of acting by integrating into the functioning of glutamate receptors of the NMDA type fundamentals in the regulation of motor, sensory and cognitive systems. Read More

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December 2018
1 Read

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.

Hum Mol Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. Structural changes in the macula are associated with many ocular diseases, including age-related macular degeneration (AMD) and glaucoma. Although macular thickness is a highly heritable trait, there are no prior reported genome-wide association studies (GWASs) of it. Read More

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December 2018

Cuticular drusen associated with aneurysmal type 1 neovascularization (polypoidal choroidal vasculopathy).

Int J Retina Vitreous 2018 5;4:44. Epub 2018 Dec 5.

1Vitreous Retina Macula Consultants of New York, 460 Park Ave., New York, NY 10022 USA.

Background: Aneurysmal type 1 neovascularization (AT1) is a term recently introduced to better describe the aneurysmal dilatation that may arise from neovascular lesions, more commonly known as polypoidal choroidal vasculopathy. The proposed term, AT1, includes an expanded clinical spectrum of aneurysmal (polypoidal) lesions observed in both different ethnicities and associated with varied clinical phenotypes.

Case Presentation: A 61-year-old woman of European descent was referred for a new, asymptomatic retinal hemorrhage found on routine examination. Read More

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December 2018

Imaging retinal melanin: a review of current technologies.

J Biol Eng 2018 4;12:29. Epub 2018 Dec 4.

1Morgridge Institute for Research, Madison, WI USA.

The retinal pigment epithelium (RPE) is essential to the health of the retina and the proper functioning of the photoreceptors. The RPE is rich in melanosomes, which contain the pigment melanin. Changes in RPE pigmentation are seen with normal aging and in diseases such as albinism and age-related macular degeneration. Read More

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December 2018

The Prohormone Proinsulin as a Neuroprotective Factor: Past History and Future Prospects.

Front Mol Neurosci 2018 26;11:426. Epub 2018 Nov 26.

3D Lab, Development, Differentiation and Degeneration, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CIB/CSIC), Madrid, Spain.

Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied in the field of endocrinology, the bioactivity of the proinsulin molecule itself has received much less attention. Insulin binds to isoforms A and B of the insulin receptor (IR) with high affinity. Read More

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November 2018

Intravitreal Injection of Hydrogen Peroxide Induces Acute Retinal Degeneration, Apoptosis, and Oxidative Stress in Mice.

Oxid Med Cell Longev 2018 8;2018:5489476. Epub 2018 Nov 8.

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, China.

Purpose: Oxidative stress is a common pathological condition for multiple retinal diseases. Hydrogen peroxide (HO) has been applied as an oxidative stress inducer for the studies. Here, we report the effect of HO exposure to the mouse retina and its underlying mechanism. Read More

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November 2018

Expanding the role of medical retina virtual clinics using multimodal ultra-widefield and optical coherence tomography imaging.

Clin Ophthalmol 2018 15;12:2337-2345. Epub 2018 Nov 15.

Newcastle Eye Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK,

Background: An increasingly elderly population with a corresponding increase in ophthalmic conditions has led to increased pressure on hospital eye services (HES). In this study, we evaluated the use of a medical retina virtual clinic (MRVC), which has expanded into assessing all new medical retina referrals, where the need for urgent treatment was not clear.

Methods: Retrospective analysis of all new patients who were seen in the MRVC between April 2016 and May 2018. Read More

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November 2018

A transcriptomics analysis of the Tbx5 paralogues in zebrafish.

PLoS One 2018 10;13(12):e0208766. Epub 2018 Dec 10.

Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America.

TBX5 is essential for limb and heart development. Mutations in TBX5 are associated with Holt-Oram syndrome in humans. Due to the teleost specific genome duplication, zebrafish have two copies of TBX5: tbx5a and tbx5b. Read More

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December 2018

In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina.

Sci Rep 2018 Dec 7;8(1):17700. Epub 2018 Dec 7.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Retinal degenerative diseases, due to the lack of regeneration systems and self-renewable cells, often lead to visual impairment. Pax6 is a pleiotropic transcription factor and its expression level determines self-renewal status or differentiation of retinal cells. Here, we investigated the fate of simultaneous induction of retinal ganglion cell death and Pax6 overexpression in retro-differentiation of retinal cells and their commitment to re-enter into the cell cycle. Read More

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December 2018

Asian perspective of eye diseases.

Eye (Lond) 2018 Dec 7. Epub 2018 Dec 7.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

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December 2018

The assessment of retina in pregnant women with myopia.

Neuro Endocrinol Lett 2018 Oct 12;39(4):321-324. Epub 2018 Oct 12.

Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland.

Objectives: Myopia is associated with increased frequency of retinal degenerative changes which are the risk factors of intra- and postpartal ophthalmological complications. Aim of this study was to analyze the degenerative lesions detected in opthalmological examination (including peripheral retinal lesions) as a potential risk factors for eyes' status in terms of delivery in myopic women.

Material And Methods: 254 pregnant women affected with myopia underwent opthalmological examination as a screening method to examine retina. Read More

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October 2018

[Infective endocarditis in a patient with vision disorders].

Pol Merkur Lekarski 2018 Nov;45(269):198-200

5th Military Clinical Hospital with Polyclinic in Cracow, Poland.

Roth spots are petechiae of the retina with a white or pale center that corresponds to a bundle of cotton wool or a multinuclear leukocyte aggregate. Often considered a sign of bacterial endocarditis, they are an unspecific symptom, usually more commonly seen in patients with hematopoietic system diseases. A 56-year-old patient reported to the hospital due to sudden visual impairment. Read More

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November 2018

Scleral Fixation of Posterior Chamber Hydrophobic Acrylic Intraocular Lenses Using Gore-Tex Suture.

Retina 2018 Nov 28. Epub 2018 Nov 28.

The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania.

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November 2018

FLUORESCEIN ANGIOGRAPHY FINDINGS IN UNILATERAL PERSISTENT FETAL VASCULATURE.

Retina 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Chang-Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Objective: This study aims to examine retinal vascular findings for affected eyes and contralateral eyes as well in typical cases of unilateral persistent fetal vasculature.

Methods: We retrospectively reviewed all patients evaluated at Chang Gung Memorial Hospital, Linkou, for unilateral persistent fetal vasculature between January 2008 and July 2017. All patients underwent fluorescein angiography (FA) examination under general anesthesia. Read More

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November 2018

COMPARATIVE EVALUATION OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY, ULTRASOUND BIOMICROSCOPY, AND INTRAOCULAR PRESSURE CHANGES AFTER PANRETINAL PHOTOCOAGULATION BY PASCAL AND CONVENTIONAL LASER.

Retina 2018 Nov 28. Epub 2018 Nov 28.

Glaucoma Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To compare intraocular pressure, anterior segment optical coherence tomography, and ultrasound biomicroscopy parameters over 3 months after panretinal photocoagulation (PRP) for proliferative diabetic retinopathy after 1 of 2 sittings by conventional laser (half PRP) and a single sitting of Pattern Scan Laser (PASCAL) PRP.

Methods: This was a prospective, randomized, interventional study. All tests were performed at baseline, and at 1, 6, and 24 hours, and 1, 4, 8, and 12 weeks after PRP. Read More

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November 2018

Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: Potential treatment for depression.

J Lipid Res 2018 Dec 10. Epub 2018 Dec 10.

University of Illinois at Chicago, United States;

EPA and DHA protect against multiple metabolic and neurologic disorders. Although DHA appears more effective for neuroinflammatory conditions, EPA is more beneficial for depression. However, the brain contains negligible amounts of EPA, and dietary supplements fail to increase it appreciably. Read More

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December 2018

Development and Validation of a Diabetic Retinopathy Screening Modality Using a Hand-Held Nonmydriatic Digital Retinal Camera by Physician Graders at a Tertiary-Level Medical Clinic: Protocol for a Validation Study.

JMIR Res Protoc 2018 Dec 10;7(12):e10900. Epub 2018 Dec 10.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Visual impairment and blindness from diabetic retinopathy (DR), which can be reduced by early screening and treatment, is an emerging public health concern in low-income and middle-income countries (LMICs) owing to the increasing prevalence of diabetes mellitus (DM). However, no systematic screening exists in most LMIC settings. The Western province of Sri Lanka has the highest prevalence of DM (18. Read More

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December 2018

Weakly-Supervised Lesion Detection from Fundus Images.

IEEE Trans Med Imaging 2018 Dec 6. Epub 2018 Dec 6.

Early diagnosis and continuous monitoring of patients suffering from eye diseases have been major concerns in the computer-aided detection (CAD) techniques. Detecting one or several specific types of retinal lesions has made a significant breakthrough in computed-aid screen in the past few decades. However, due to variety of retinal lesions and complex normal anatomical structures, automatic detection of lesions with unknown and diverse types from a retina remains a challenging task. Read More

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December 2018

Characterisation of poor visual outcomes of neovascular age-related macular degeneration treated with anti-vascular endothelial growth factor agents.

Ophthalmology 2018 Dec 6. Epub 2018 Dec 6.

Marsden Eye Specialists, Parramatta, Australia.

Purpose: To investigate the incidence, characteristics and baseline predictors of poor visual outcomes in eyes with neovascular age-related macular degeneration (nAMD) receiving intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents in daily clinical practice.

Design: Observational study.

Participants: Treatment-naïve eyes starting anti-VEGF therapy for nAMD between 2007 and 2012 tracked in the Fight Retinal Blindness! registry. Read More

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December 2018
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LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis.

Exp Mol Pathol 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, The Third Xiangya Hospital of Central South University, Changsha 410013, PR China. Electronic address:

Background: Diabetic retinopathy (DR) is the serious complication of diabetes, which could lead to blindness. Inflammation and apoptosis are hallmark of DR, but mechanism of their regulation is little known. LncRNA-MEG3 is associated with multiple biological processes including proliferation, apoptosis and inflammation response, and is dramatically decreased in DR. Read More

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December 2018

Hydrophobic drug adsorption loss to syringe filters from a perspective of drug delivery.

J Pharmacol Toxicol Methods 2018 Dec 4. Epub 2018 Dec 4.

Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, Zhejiang 325027, China; Jacob's Retina Center at Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA 92037-0946, United States. Electronic address:

Filtering with a syringe filter is a common operation in pharmaceutical analysis. Ophthalmic research often has a limited amount of sample and low amount of drug which is vulnerable to filtering membrane adsorption loss but not well recognized in the research community. Current study investigated drug adsorption by 11 types of syringe filters for 4 hydrophobic compounds commonly encountered in transscleral drug delivery. Read More

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December 2018

Preclinical Evaluation of ADVM-022, a Novel Gene Therapy Approach to Treating Wet Age-Related Macular Degeneration.

Mol Ther 2018 Nov 13. Epub 2018 Nov 13.

Adverum Biotechnologies, Menlo Park, CA, USA. Electronic address:

Inhibition of vascular endothelial growth factor, a key contributor to the choroidal neovascularization associated with wet age-related macular degeneration, is the mode of action of several approved therapies, including aflibercept, which requires frequent intravitreal injections to provide clinical benefit. Lack of compliance with the dosing schedule may result in recurrence of active wet macular degeneration, leading to irreversible vision impairment. Gene therapy providing sustained anti-vascular endothelial growth factor levels in the retina following a single injection could drastically reduce the treatment burden and improve visual outcomes. Read More

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November 2018

Bi-directional Control of Walking Behavior by Horizontal Optic Flow Sensors.

Curr Biol 2018 Dec 1. Epub 2018 Dec 1.

Circuits - Computation - Models, Max Planck Institute of Neurobiology, Am Klopferspitz 18, Martinsried 82152, Germany. Electronic address:

Moving animals experience constant sensory feedback, such as panoramic image shifts on the retina, termed optic flow. Underlying neuronal signals are thought to be important for exploratory behavior by signaling unintended course deviations and by providing spatial information about the environment [1, 2]. Particularly in insects, the encoding of self-motion-related optic flow is well understood [1-5]. Read More

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December 2018

Blood-to-Retina Transport of Imperatorin Involves the Carrier Mediated Transporter System at the Inner Blood-Retinal Barrier.

J Pharm Sci 2018 Dec 4. Epub 2018 Dec 4.

College of Pharmacy and Research Center for Cell Fate Control, Sookmyung Women's University, Chungpa-dong 2-ga, Yongsan-gu, Seoul, 04310, Republic of Korea. Electronic address:

This study investigated the mechanism of transporting imperatorin across the inner blood-retinal barrier (iBRB). The carotid artery single injection method was used to calculate the retinal uptake index (RUI) of [H]imperatorin in vivo while the retinal capillary endothelial cell lines were used for the in vitro uptake and mRNA expression assays. RUI value of [H]imperatorin was greater than that of the reference compound ([C]n-butanol). Read More

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December 2018

Optical coherence tomography angiography of the macula and optic nerve head: microvascular density and test-retest repeatability in normal subjects.

BMC Ophthalmol 2018 Dec 10;18(1):315. Epub 2018 Dec 10.

Department of Ophthalmology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

Background: Despite the potential usefulness of optical coherence tomography angiography in retinal and optic disc conditions, the reliability of the imaging modality remains unclear. This study set out to measure the microvascular density of macula and optic disc by mean of optical coherence tomography angiography and report the repeatability of the vessel density measurements.

Methods: Cross sectional observational cohort study. Read More

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December 2018

Transplantation of retinal progenitor cells from optic cup-like structures differentiated from human embryonic stem cells in vitro and in vivo generation of retinal ganglion-like cells.

Stem Cells Dev 2018 Dec 10. Epub 2018 Dec 10.

Fudan University, Department of Anatomy, Histology and Embryology, Shanghai, China ;

Human embryonic stem cells (hESCs) have the potential to differentiate along the retinal lineage. We have efficiently differentiated human pluripotent stem cells (hPSCs) into optic cup-like structures by using a novel retinal differentiation medium (RDM).The purpose of this study was to determine whether the retinal progenitor cells (RPCs) derived from hESCs can integrate into the host retina and differentiate into retinal ganglion cells (RGCs) in vivo. Read More

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December 2018

Retinal degeneration is associated with brain volume reduction and prognosis in radiologically isolated syndrome.

Mult Scler 2018 Dec 11:1352458518817987. Epub 2018 Dec 11.

Department of Neurology, Hacettepe University, Ankara, Turkey.

Background:: The extent of neurodegeneration in the earliest stages of central nervous system (CNS) demyelination is not known. Optical coherence tomography (OCT) is a powerful tool to study neurodegeneration in demyelinating disorders.

Objectives:: To study neuroaxonal loss in the retina of individuals with radiologically isolated syndrome (RIS) and investigate whether OCT measurements are associated with brain volumetrics and clinical conversion to multiple sclerosis (MS). Read More

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December 2018

Organ- on -a- chip technologies that can transform ophthalmic drug discovery and disease modeling.

Expert Opin Drug Discov 2018 Dec 8:1-11. Epub 2018 Dec 8.

b Department of Women's Health, Research Institute for Women's Health , Eberhard Karls University Tübingen , Tübingen , Germany.

Introduction: Disorders of the eye that lead to visual impairment are affecting millions of people worldwide. Nevertheless, for many of these disorders, there are still no effective treatment options available due to the lack of in vitro model systems that emulate the physiological in vivo structure and function of human eyes. Microphysiological organ-on-a-chip (OoC) technology represents a novel and powerful approach to overcome the limitations of conventional model systems and lead to a paradigm shift in ophthalmic research. Read More

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December 2018

Techniques for improving ophthalmic studies performed on administrative databases.

Ophthalmic Epidemiol 2018 Dec 6:1-3. Epub 2018 Dec 6.

e Department of Ophthalmology , Scheie Eye Institute, University of Pennsylvania , Philadelphia , Pennsylvania , USA.

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December 2018
1 Read

Evaluation of RETICs Glaucoma Diagnostic Calculators in Preperimetric Glaucoma.

Transl Vis Sci Technol 2018 Nov 30;7(6):13. Epub 2018 Nov 30.

Institut Catalá de Retina, Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To evaluate two glaucoma diagnostic calculators (GDC) in a group of eyes with preperimetric glaucoma (PPG).

Methods: All eyes ( = 265) included in this study had ocular hypertension with normal visual fields (VFs) on repeated VF tests. PPG was defined as progression in the Guided Progression Analysis software from Cirrus-optical coherence tomography (GPA-OCT). Read More

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November 2018

Multimodal imaging in a patient with Prader-Willi syndrome.

Int J Retina Vitreous 2018 30;4:45. Epub 2018 Nov 30.

Gavin Herbert Eye Institute, University of California Irvine, 850 Health Sciences Road, Irvine, CA 92697 USA.

Background: Prader-Willi syndrome (PWS) is a genetic disease caused by loss of expression of the paternally inherited copy of several genes on the long arm of chromosome 15. Ophthalmic manifestations of PWS include strabismus, amblyopia, nystagmus, hypopigmentation of the iris and choroid, diabetic retinopathy, cataract and congenital ectropion uvea. An overlap between PWS and oculocutaneous albinism (OCA) has long been recognized and attributed to deletion of OCA2 gene located in PWS critical region (PWCR). Read More

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November 2018
1 Read

A proposed mechanism influencing structural patterns in X-linked retinoschisis and stellate nonhereditary idiopathic foveomacular retinoschisis.

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Vitreous Retina Macula Consultants of New York, New York, NY, USA.

Objective: To explore the structural differences between X-linked retinoschisis (XLR) and stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) using swept-source optical coherence tomography angiography (SS-OCTA).

Methods: A case series of two patients, a 9-year-old male with XLR and a 58-year-old woman with SNIFR were imaged with swept-source optical coherence tomography angiography (SS-OCTA; PLEX Elite 900, Carl Zeiss Meditec, Inc, Dublin, CA). Automated segmentation was manually adjusted to include the areas of retinoschisis within en face flow and structural slabs. Read More

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December 2018

Akinetic swept-source optical coherence tomography based on a pulse-modulated active mode locking fiber laser for human retinal imaging.

Sci Rep 2018 Dec 5;8(1):17660. Epub 2018 Dec 5.

Advanced Photonics Research Institute, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea.

Optical coherence tomography (OCT) is a noninvasive imaging modality that can provide high-resolution, cross-sectional images of tissues. Especially in retinal imaging, OCT has become one of the most valuable imaging tools for diagnosing eye diseases. Considering the scattering and absorption properties of the eye, the 1000-nm OCT system is preferred for retinal imaging. Read More

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December 2018

Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Department of Animal Radiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.

In diabetic retinopathy (DR), pericyte dropout from capillary walls is believed to cause the breakdown of the blood-retina barrier (BRB), which subsequently leads to vision-threatening retinal edema. While various proinflammatory cytokines and chemokines are upregulated in eyes with DR, their distinct contributions to disease progression remain elusive. Here, we evaluated roles of stromal cell-derived factor-1α (SDF-1α) and its receptor CXCR4 in the BRB breakdown initiated by pericyte deficiency. Read More

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December 2018

Spinal cord and infratentorial lesions in radiologically isolated syndrome are associated with decreased retinal ganglion cell/inner plexiform layer thickness.

Mult Scler 2018 Dec 3:1352458518815597. Epub 2018 Dec 3.

Division of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background:: The role of retinal imaging with optical coherence tomography (OCT) in assessing individuals with radiologically isolated syndrome (RIS) remains largely unexplored.

Objective:: To assess retinal layer thicknesses in RIS and examine their associations with clinical features suggestive of increased risk for conversion to multiple sclerosis (MS).

Methods:: A total of 30 RIS subjects and 60 age- and sex-matched healthy controls (HC) underwent retinal imaging with spectral-domain OCT, followed by automated segmentation of retinal layers. Read More

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December 2018
1 Read

Evidence of retinal degeneration in Wolfram syndrome.

Ophthalmic Genet 2018 Dec 3:1-5. Epub 2018 Dec 3.

b Cole Eye Institute , Cleveland Clinic , Cleveland , OH , USA.

Purpose: Wolfram syndrome is characterized by early onset diabetes mellitus, diabetes insipidus, deafness, and optic atrophy, but retinal degeneration has not been described as a major component of the phenotype. We present two cases with Wolfram syndrome and evidence of retinal degeneration.

Materials And Methods: Observational case series. Read More

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December 2018
1 Read

Identification of calretinin-expressing retinal ganglion cells projecting to the mouse superior colliculus.

Cell Tissue Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Biology, School of Life Sciences, BK 21 Plus KNU Creative BioResearch Group, College of Natural Sciences, and Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41566, South Korea.

In mice, retinal ganglion cells (RGCs), which consist of around 30 subtypes, exclusively transmit retinal information to the relevant brain systems through parallel visual pathways. The superior colliculus (SC) receives the vast majority of this information from several RGC subtypes. The objective of the current study is to identify the types of calretinin (CR)-expressing RGCs that project to the SC in mice. Read More

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December 2018

Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity.

Ophthalmol Retina 2018 Sep 21;2(9):963-971. Epub 2018 Mar 21.

Department of Ophthalmology, Duke University, Durham, NC, 27710, USA.

Purpose: Bedside examination of premature infants at risk for retinopathy of prematurity (ROP) is predominantly performed with ophthalmoscopic viewing of the retina. While postmortem retinal microstructures have been studied at the vascular-avascular junction, a critical location for pathogenesis of ROP, to date this has not been possible . Here we present bedside, non-sedated cross-sectional imaging and analysis of retinal microstructures at the vascular-avascular junction in infants with ROP using handheld spectral-domain optical coherence tomography (SDOCT). Read More

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September 2018
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Atrophy in Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 15.

Ophthalmol Retina 2018 Oct 2;2(10):1021-1027. Epub 2018 Jun 2.

Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, Maryland.

Purpose: To identify the development and progression of macular retinal pigment epithelial atrophy in eyes with neovascular (CNV) age-related macular degeneration (AMD) and to correlate with visual acuity (VA).

Design: Cohort study.

Participants: Age-Related Eye Disease Study 2 (AREDS2) participants with intermediate AMD enrolled in a randomized controlled clinical trial of oral supplements. Read More

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October 2018

Macular pigment density changes in central serous chorioretinopathy.

Rom J Ophthalmol 2018 Jul-Sep;62(3):222-227

Ophthalmology Department, Bucharest University Emergency Hospital, Bucharest, Romania.

To present a series of 2 cases of central serous chorioretinopathy and the changes in the macular pigment optical density during the evolution of the disease. A 32-year-old patient presented himself for blurred vision on his LE. The SD OCT imaging revealed serous macular detachment of the neurosensory retina on the LE. Read More

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December 2018