7,499 results match your criteria Resuscitation[Journal]


The EXACT protocol: a multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Epidemiology and Preventive Medicine, Monash University, Australia; Prehospital, Resuscitation and Emergency Care Research Unit, Curtin University, Australia; Alfred Hospital, Australia; Ambulance Victoria, Australia; Department of Community Emergency Health and Paramedic Practice, Monash University, Australia; SA Ambulance Service, Australia; Flinders University, Australia; St John Ambulance Western Australia, Australia; Warwick University, United Kingdom.

Background: Experimental and observational research suggests hyperoxia following resuscitation from cardiac arrest is associated with neurological injury and worse clinical outcomes. This paper describes the rationale and design of the EXACT trial. EXACT aims to determine whether reducing oxygen in the acute phase of post-resuscitation care for out-of-hospital cardiac arrest (OHCA) improves survival. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.023DOI Listing

Impella use in acute myocardial infarction complicated by cardiogenic shock and cardiac arrest : Analysis of 10 years registry data.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Aims: To assess characteristics and outcome of patients treated with Impella for acute myocardial infarction (AMI) complicated by severe cardiogenic shock (CS) or cardiac arrest (CA).

Methods And Results: From 2008 through 2017, 92 patients with AMI complicated by CS were treated with Impella. Survival varied according to clinical presentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009572193013
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http://dx.doi.org/10.1016/j.resuscitation.2019.04.022DOI Listing
April 2019
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Large Urban Center Improves Out-of-Hospital Cardiac Arrest Survival.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency Medicine, University of Illinois at Chicago. Electronic address:

Background: Large cities pose unique challenges that limit the effectiveness of system improvement interventions. Successful implementation of integrated cardiac resuscitation systems of care can serve as a model for other urban centers.

Methods: This was a retrospective analysis of prospectively collected data of adult cases of non-traumatic cardiac arrest who received treatment by Chicago Fire Department EMS from September 1, 2013 through December 31, 2016. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.019DOI Listing

Effect of Endotracheal Intubation and Supraglottic Airway Device Placement during Cardiopulmonary Resuscitation on Carotid Blood Flow over Resuscitation Time: An Experimental Porcine Cardiac Arrest Study.

Resuscitation 2019 Apr 19. Epub 2019 Apr 19.

Department of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea. Electronic address:

Background: Supraglottic airway devices (SGDs) are widely used during the resuscitation of out-of-hospital cardiac arrest (OHCA). The effect of SGDs on carotid blood flow (CBF) as resuscitation time passes is controversial. We assessed the effects of endotracheal intubation (ETI) and 3 types of SGD placement on CBF over time in prolonged resuscitation through an experimental porcine cardiac arrest study. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.020DOI Listing
April 2019
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Hippocampus and basal ganglia as potential sentinel sites for ischemic pathology after resuscitated cardiac arrest.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

Department of Clinical Sciences, Division of Pathology and Oncology, Lund University, Sweden.

Aims Of The Study: Neurological impairment after resuscitated cardiac arrest (CA) remains a significant unmet medical need. Brain ischemia associated with CA and subsequent reperfusion is evident as two fundamentally different types of damage on neuropathological examination: frank necrosis (involving all cell types) and selective eosinophilic neuronal death (SEND). These types of damage are not only dissimilar in micromorphology, but also differently detectable with clinical brain imaging methods. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.012DOI Listing

Forecasting HOPE: Risk prediction in rare events.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

NIHR Bristol Biomedical Research Centre, University of Bristol, UK; Clinical Trials and Evaluation Unit, Bristol Trials Centre, University of Bristol, UK.

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.014DOI Listing

Comparing bystander response to a sudden cardiac arrest using a virtual reality CPR training mobile app versus a standard CPR training mobile app.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

Center for Resuscitation Science and Department of Emergency Medicine, Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine; Department of Family Medicine and Community Health, Duke University, Durham, NC.

Background: Using a mobile Virtual Reality (VR) platform to heighten realism for cardiopulmonary resuscitation (CPR) training has the potential to improve bystander response.

Objectives: We examined whether using a VR mobile application (mApp) for CPR training would improve bystander response compared with a standard mApp CPR training.

Methods: We randomized lay bystanders to either our intervention arm (VR mApp) or our control arm (mApp). Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.017DOI Listing

The Effect of Fractional Inspired Oxygen Concentration on Early Warning Score Performance: a database analysis.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

NIHR Biomedical Research Centre Oxford, Kadoorie Centre for Critical Care Research and Education, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 3, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU. Electronic address:

Objectives: To calculate fractional inspired oxygen concentration (FiO) thresholds in ward patients and add these to the National Early Warning Score (NEWS). To evaluate the performance of NEWS-FiO against NEWS when predicting in-hospital death and unplanned intensive care unit (ICU) admission.

Methods: A multi-centre, retrospective, observational cohort study was carried out in five hospitals from two UK NHS Trusts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009572193011
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http://dx.doi.org/10.1016/j.resuscitation.2019.04.002DOI Listing
April 2019
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The response to patient deterioration in the UK National Health Service - a survey of acute hospital policies.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

Portsmouth Hospitals NHS Trust & University of Southampton, Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth PO6 3LY UK.

Background: The assessment of acute-illness severity in adult non-pregnant patients in the United Kingdom is based on early warning score (EWS) values that determine the urgency and nature of the response to patient deterioration. This study aimed to describe, and identify variations in, the expected clinical response outlined in 'deteriorating patient' policies/guidelines in acute NHS hospitals.

Methods: A copy of the local 'deteriorating patient' policy/guideline was requested from 152 hospitals. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.016DOI Listing
April 2019
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NEWS2 needs to be tested in prospective trials involving patients with confirmed hypercapnia.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

Salford Royal NHS Foundation Trust, Respiratory Medicine, Stott Lane, Salford, M6 8HD, United Kingdom.

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.047DOI Listing

Capnography: A support tool for the Detection of Return of Spontaneous Circulation in Out-of-Hospital Cardiac Arrest.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

Department of Emergency Medicine.University of Texas SouthWestern Medical Center (UTSW).Dallas, United States.

Background: Automated detection of return of spontaneous circulation (ROSC) is still an unsolved problem during cardiac arrest. Current guidelines recommend the use of capnography, but most automatic methods are based on the analysis of the ECG and thoracic impedance (TI) signals. This study analysed the added value of EtCO for discriminating pulsed (PR) and pulseless (PEA) rhythms and its potential to detect ROSC. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.048DOI Listing

Usefulness of Cerebral rSO Monitoring During CPR to Predict the Probability of Return of Spontaneous Circulation.

Resuscitation 2019 Apr 17. Epub 2019 Apr 17.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-oka, Suita, Osaka 565-0871, Japan.

Background: Cerebral oximetry (rSO) may be useful in assessing the probability of return of spontaneous circulation (ROSC). However, the potential of assessing the trend in the rSO value has not been discussed when determining the probability of ROSC.

Methods: This was a retrospective study of out-of-hospital cardiac arrest (OHCA) patients with continuous rSO values recorded during cardiopulmonary arrest. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.015DOI Listing

Which PART of the question are you asking?

Authors:
David C Cone

Resuscitation 2019 Apr 16. Epub 2019 Apr 16.

Yale University School of Medicine, New Haven, Connecticut, USA. Electronic address:

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.013DOI Listing

Dispatcher-assisted cardiopulmonary resuscitation for paediatric out-of-hospital cardiac arrest: A structured evaluation of communication issues using the SACCIA safe communication typology.

Resuscitation 2019 Apr 15. Epub 2019 Apr 15.

Department of Emergency Medicine, KK Women's & Children's Hospital, 100 Bukit Timah Road, 229899 Singapore. Electronic address:

Aim: To evaluate communication issues during dispatcher-assisted cardiopulmonary resuscitation (DACPR) for paediatric out-of-hospital cardiac arrest in a structured manner to facilitate recommendations for training improvement.

Methods: A retrospective observational study evaluated DACPR communication issues using the SACCIA Safe Communication typology (Sufficiency, Accuracy, Clarity, Contextualization, Interpersonal Adaptation). Telephone recordings of 31 cases were transcribed verbatim and analysed with respect to encoding, decoding and transactional communication issues. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.009DOI Listing

The ventricular fibrillation waveform in relation to shock success in early vs. late phases of out-of-hospital resuscitation.

Resuscitation 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.

Background: The amplitude spectrum area (AMSA) of the ventricular fibrillation (VF) waveform predicts shock success and clinical outcome after out-of-hospital cardiac arrest (OHCA). Recently, also AMSA-changes demonstrated prognostic value. Until now, most studies focused on early shocks, while many patients require prolonged resuscitations. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.010DOI Listing
April 2019
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Evoked potentials improve multimodal prognostication after cardiac arrest.

Resuscitation 2019 Apr 14. Epub 2019 Apr 14.

Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

Aim: Predicting recovery in comatose post-cardiac arrest patients requires multiple modalities of prognostic assessment. In isolation, absent N20 cortical responses in somatosensory evoked potentials (SSEPs) are a specific predictor of poor outcome. It is unknown whether SSEP results, when assessed in the context of prior knowledge (demographic and clinical information), change the pretest predicted probability of recovery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009572193012
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http://dx.doi.org/10.1016/j.resuscitation.2019.04.011DOI Listing
April 2019
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Neurocognitive outcomes in survivors of pediatric E-CPR: Has the Golden age arrived?

Resuscitation 2019 Apr 13. Epub 2019 Apr 13.

Department of Pediatrics, Division of Pediatric Critical Care Medicine, Stollery Children's Hospital and University of Alberta, Edmonton, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.001DOI Listing
April 2019
2 Reads

Impact of adrenaline dose and timing on out-of-hospital cardiac arrest survival and neurological outcomes.

Resuscitation 2019 Apr 13. Epub 2019 Apr 13.

Center for Resuscitation Science and the Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Study Objective: The 2015 ILCOR Advanced Cardiovascular Life Support Guidelines recommend intravenous adrenaline (epinephrine) as a crucial pharmacologic treatment during cardiac arrest resuscitation. Some recent observational studies and clinical trials have questioned the efficacy of its use and suggested possible deleterious effects on overall survival and long-term outcomes. This study aimed to describe the association between time and dose of adrenaline on return of spontaneous circulation (ROSC) and neurologic function. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.018DOI Listing
April 2019
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Exercise-related out-of-hospital cardiac arrest in Victoria, Australia.

Resuscitation 2019 Apr 11;139:57-64. Epub 2019 Apr 11.

Centre for Research and Evaluation, Ambulance Victoria, Doncaster, Victoria, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Background: Characteristics and outcomes of exercise-related out-of-hospital cardiac arrests (OHCA) are not well described in Australia.

Methods: This was a retrospective observational study of non-exercise-related aetiology and exercise-related OHCAs from the Victorian Ambulance Cardiac Arrest Registry between 2008 and 2016, including 12-month quality of life data from 2010 to 2016. Exercise-related OHCA was defined as taking place during or within 1 h of at least moderate intensity exercise. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.043DOI Listing
April 2019
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Advanced airway management during adult cardiac arrest: A systematic review.

Resuscitation 2019 Apr 11. Epub 2019 Apr 11.

Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Intensive Care Medicine, Randers Regional Hospital, Randers, Denmark. Electronic address:

Aim: To systematically review the literature on advanced airway management during adult cardiac arrest in order to inform the International Liaison Committee of Resuscitation (ILCOR) consensus on science and treatment recommendations.

Methods: The review was performed according to PRISMA guidelines and registered on PROSPERO (CRD42018115556). We searched Medline, Embase, and Evidence-Based Medicine Reviews for controlled trials and observational studies published before October 30, 2018. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.003DOI Listing

Vasopressors during adult cardiac arrest: A systematic review and meta-analysis.

Resuscitation 2019 Apr 10. Epub 2019 Apr 10.

Center for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address:

Aim: To systematically review the literature on the use of vasopressors during adult cardiac arrest to inform an update of international guidelines.

Methods: PRISMA guidelines were followed. We searched Medline, Embase, Web of Science, CINAHL, and the Cochrane Library for controlled trials and observational studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009572193012
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http://dx.doi.org/10.1016/j.resuscitation.2019.04.008DOI Listing
April 2019
3 Reads

Deep-learning-based out-of-hospital cardiac arrest prognostic system to predict clinical outcomes.

Resuscitation 2019 Apr 9. Epub 2019 Apr 9.

Division of Cardiology, Cardiovascular Center, Mediplex Sejong Hospital, Incheon, Republic of Korea.

Aim: Out-of-hospital cardiac arrest (OHCA) is a major healthcare burden, and prognosis is critical in decision-making for treatment and the withdrawal of life-sustaining therapy. This study aimed to develop and validate a deep-learning-based out-of-hospital cardiac arrest prognostic system (DCAPS) for predicting neurologic recovery and survival to discharge.

Methods: The study subjects were patients from the Korea OHCA registry who experienced return of spontaneous circulation (ROSC) after OHCA. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.007DOI Listing

End tidal CO and cerebral oximetry for the prediction of return of spontaneous circulation during cardiopulmonary resuscitation.

Resuscitation 2019 Apr 9. Epub 2019 Apr 9.

Department of Emergency Medicine, Wayne State University, 6G UHC, 4201St., Antoine, Detroit, MI, 48201, United States. Electronic address:

Background: End Tidal CO (ETCO) is a reasonable predictor of Return of Spontaneous Circulation (ROSC) in cardiac arrest (CA), though with many limitations. Cerebral Oximetry (CerOx) non-invasively measures brain O saturation and correlates with flow.

Objectives: This study compares ETCO and CerOx for ROSC prediction during both out of hospital (OHCA) and emergency department cardiac arrests (EDCA). Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.006DOI Listing
April 2019
3 Reads

Is point-of-care ultrasound a reliable predictor of outcome during atraumatic, non-shockable cardiac arrest? A systematic review and meta-analysis from the SHoC investigators.

Resuscitation 2019 Apr 9. Epub 2019 Apr 9.

Department of Emergency Medicine, University of Ottawa, Ottawa Hospital Research Institute, Canada.

Aims: To evaluate the accuracy of PoCUS in predicting return of spontaneous circulation (ROSC), survival to hospital admission (SHA), and survival to hospital discharge (SHD) in adult non-traumatic, non-shockable out-of-hospital or emergency department cardiac arrest.

Methods: Medline, EMBASE, Cochrane, CINAHL, ClinicalTrials.gov and the World Health Organization Registry were searched for eligible studies. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.027DOI Listing
April 2019
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Hemodynamic efficiency of hemodialysis treatment with high cut-off membrane during the early period of post-resuscitation shock: The HYPERDIA trial.

Resuscitation 2019 Apr 8. Epub 2019 Apr 8.

Medical Intensive Care Unit, Cochin University Hospital, APHP, Paris, France; Paris Descartes University, Sorbonne Paris Cité-Medical School, Paris, France; Sudden Death Expertise Centre, INSERM U970 (team 4), Paris Cardiovascular Research Centre, Paris, France. Electronic address:

Background: After resuscitation of cardiac arrest (CA), an acute circulatory failure occurs in about 50% of cases, which shares many characteristics with septic shock. Most frequently, supportive treatments are poorly efficient to prevent multiple organ failure and death. We evaluated whether an early plasma removal of inflammatory mediators using high cut-off continuous veno-venous hemodialysis (HCO-CVVHD) could improve hemodynamic status and outcome of these patients. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.045DOI Listing
April 2019
2 Reads

Interhospital transfer in low-volume and high-volume emergency departments and survival outcomes after out-of-hospital cardiac arrest: A nationwide observational study and propensity score-matched analysis.

Resuscitation 2019 Apr 8;139:41-48. Epub 2019 Apr 8.

Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea. Electronic address:

Introduction: Post-resuscitation care of out-of-hospital cardiac arrest (OHCA) patients often involves inter-hospital transfer (IHT). We aimed to determine the association between IHT and outcomes of OHCA.

Methods: This cross-sectional study used data from the nationwide emergency medical services (EMS)-based OHCA registry in Korea. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.044DOI Listing

Author response: A critique of the recent 2018 ERC CPR guidelines.

Resuscitation 2019 Apr 6. Epub 2019 Apr 6.

European Resuscitation Council, Emile Vanderveldelaan 35, BE-2845, Niel, Belgium.

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.005DOI Listing

A critique of the recent 2018 ERC CPR guidelines.

Authors:
Zohar Lederman

Resuscitation 2019 Apr 7. Epub 2019 Apr 7.

Emergency Department, Assuta Samson Hospital, Ashdod, Israel; Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.resuscitation.2018.12.024DOI Listing

Differential outcomes following successful resuscitation in cardiac arrest due to drug overdose.

Resuscitation 2019 Apr 6;139:9-16. Epub 2019 Apr 6.

Department of Neurology, Boston University School of Medicine, 75 East Newton Street, Boston MA 02118, USA. Electronic address:

Background: Data pertaining to clinical characteristics and outcomes of cardiac arrest (CA) due to drug overdose (ODCA) are limited. We hypothesized that patients with ODCA would have binary outcomes (brain death or functional recovery) compared to patients in whom CA was due to another etiology.

Methods: We performed a retrospective analysis of CA cases from a single academic institution from 2012 to 2017. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.04.004DOI Listing
April 2019
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Mode of death after cardiac arrest: We need to know.

Resuscitation 2019 Apr 4;138:282-283. Epub 2019 Apr 4.

Paris-Cardiovascular-Research-Center (Sudden Death Expertise Centre), INSERM U970, Paris, France; Université Paris-Descartes-Sorbonne-Paris-Cité, Paris, France; Ramsay Générale de Santé, Hôpital Privé Jacques Cartier, France; Medical ICU, Cochin Hospital, AP-HP, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.040DOI Listing

Effect of vertical location on survival outcomes for out-of-hospital cardiac arrest in Singapore.

Resuscitation 2019 Apr 3;139:24-32. Epub 2019 Apr 3.

Department of Emergency Medicine, Singapore General Hospital, Outram Road, Singapore 169608, Singapore; Health Services & Systems Research, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.

Background: A large proportion of out-of-hospital cardiac arrest (OHCA) cases occur in high-rise residential buildings. This study aims to investigate the effect of vertical location on survival outcomes and response times.

Methods: This is a retrospective study based on data obtained from the Singapore cohort of the Pan-Asian Resuscitation Outcomes Study (PAROS) from January 2011 to December 2014. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.042DOI Listing
April 2019
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Sports activity and paediatric out-of-hospital cardiac arrest at schools in Japan.

Resuscitation 2019 Apr 3;139:33-40. Epub 2019 Apr 3.

Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamada-Oka, Suita 565-0871, Japan.

Background: Sudden cardiac death during exercise or sports is an important problem among young athletes and non-athletes. An understanding of the epidemiological features of sports-related out-of-hospital cardiac arrest (OHCA) among children is crucial for planning approaches for prevention and better outcomes of paediatric OHCAs. We assessed the characteristics and outcomes of sports-related OHCA among children at schools in Japan to prevent sports-related paediatric OHCA at schools. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009572183105
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http://dx.doi.org/10.1016/j.resuscitation.2019.03.041DOI Listing
April 2019
10 Reads

Grey-white matter ratio measured using early unenhanced brain computed tomography shows no correlation with neurological outcomes in patients undergoing targeted temperature management after cardiac arrest.

Resuscitation 2019 Apr 3. Epub 2019 Apr 3.

Department of Emergency Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. Electronic address:

Aim: This study evaluated whether the grey-white matter ratio (GWR) assessed via early brain computed tomography (CT) within 2 h after the return of spontaneous circulation (ROSC) following cardiac arrest is associated with poor neurological outcomes after 6 months in post-cardiac arrest patients treated with targeted temperature management (TTM).

Methods: This study used data from the Korean Hypothermia Network prospective registry obtained from November 2015 to October 2017 to assess patients with out-of-hospital cardiac arrest (OHCA) who underwent brain CT within 2 h following the ROSC. The primary endpoint was the neurological outcome 6 months post-cardiac arrest (cerebral performance category; CPC). Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.039DOI Listing
April 2019
2 Reads
4.167 Impact Factor

Distinct predictive values of current neuroprognostic guidelines in post-cardiac arrest patients.

Resuscitation 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurology, Yale University School of Medicine, New Haven, CT, United States; Department of Neurology, Boston University School of Medicine, Boston, MA, United States.

Purpose: To assess the performance of neuroprognostic guidelines proposed by the American Academy of Neurology (AAN), European Resuscitation Council/European Society of Intensive Care Medicine (ERC/ESICM), and American Heart Association (AHA) in predicting outcomes of patients who remain unconscious after cardiac arrest.

Methods: We retrospectively identified a cohort of unconscious post-cardiac arrest patients at a single tertiary care centre from 2011 to 2017 and reviewed hospital records for clinical, radiographic, electrophysiologic, and biochemical findings. Outcomes at discharge and 6 months post-arrest were abstracted and dichotomized as good (Cerebral Performance Category (CPC) scores of 1-2) versus poor (CPC 3-5). Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.035DOI Listing
April 2019
2 Reads

Paediatric targeted temperature management post cardiac arrest: A systematic review and meta-analysis.

Resuscitation 2019 Apr 2;139:65-75. Epub 2019 Apr 2.

Division of Emergency Medicine, McMaster University, Hamilton General Hospital, 237 Barton St E., Room 253, Hamilton, ON L8L 2X2, Canada. Electronic address:

Introduction: The International Liaison Committee on Resuscitation prioritized the need to update the review on the use of targeted temperature management (TTM) in paediatric post cardiac arrest care. In this meta-analysis, the effectiveness of TTM at 32-36 °C was compared with no target or a different target for comatose children who achieve a return of sustained circulation after cardiac arrest.

Methods: Electronic databases were searched from inception to December 13, 2018. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.038DOI Listing

Hemodynamic effects of chest compression interruptions during pediatric in-hospital cardiopulmonary resuscitation.

Resuscitation 2019 Apr 1;139:1-8. Epub 2019 Apr 1.

The Children's Hospital of Philadelphia, Department of Anesthesiology and Critical Care Medicine, 3401 Civic Center Blvd, Philadelphia, PA 19104, United States.

Aim: Animal studies have established deleterious hemodynamic effects of interrupting chest compressions. The objective of this study was to evaluate the effect of interruptions on invasively measured blood pressures (BPs) during pediatric in-hospital cardiac arrest (IHCA).

Methods: This was a single-center, observational study of pediatric (<18 years) intensive care unit IHCAs in patients with invasive arterial catheters in place. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.032DOI Listing
April 2019
2 Reads

On prognostication and withdrawal of life sustaining treatment after cardiac arrest: Does the "thin gray line" between life and death (too often) wear white?

Resuscitation 2019 Apr 1. Epub 2019 Apr 1.

Dept. of Anesthesiology, Elisabeth-TweeSteden Hospital & Dept. of Traumatology (DSATC), Radboud UMC, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.034DOI Listing

Initial arterial pH as a predictor of neurologic outcome after out-of-hospital cardiac arrest: A propensity-adjusted analysis.

Resuscitation 2019 Apr 1;139:76-83. Epub 2019 Apr 1.

Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA. Electronic address:

Background: Lower pH after out-of-hospital cardiac arrest (OHCA) has been associated with worsening neurologic outcome, with <7.2 identified as an "unfavorable resuscitation feature" in consensus treatment algorithms despite conflicting data. This study aimed to describe the relationship between decremental post-resuscitation pH and neurologic outcomes after OHCA. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.036DOI Listing

The effect of ventilation rate on outcome in adults receiving cardiopulmonary resuscitation.

Resuscitation 2019 Apr 1;138:243-249. Epub 2019 Apr 1.

Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; Department of Emergency Medicine, Antwerp University Hospital, Edegem, Belgium.

Aim: To investigate whether a ventilation rate ≤10 breaths min in adult cardiac arrest patients treated with tracheal intubation and chest compressions in a prehospital setting is associated with improved Return of Spontaneous Circulation (ROSC), survival to hospital discharge and one-year survival with favourable neurological outcome, compared to a ventilation rate >10 breaths min.

Methods: In this retrospective study, prospectively acquired data were analysed. Ventilation rates were measured with end-tidal CO and ventilation pressures. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.037DOI Listing
April 2019
1 Read

A smartphone application with augmented reality for estimating weight in critically ill paediatric patients.

Resuscitation 2019 Apr 1. Epub 2019 Apr 1.

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.033DOI Listing

The effect of an International competitive leaderboard on self-motivated simulation-based CPR practice among healthcare professionals: A randomized control trial.

Resuscitation 2019 Apr 1;138:273-281. Epub 2019 Apr 1.

Department of Paediatrics, the Research and Learning Institutes, Hospital for Sick Children, University of Toronto, Toronto, Canada.

Background: Little is known about how best to motivate healthcare professionals to engage in frequent cardiopulmonary resuscitation (CPR) refresher skills practice. A competitive leaderboard for simulated CPR can encourage self-directed practice on a small scale. The study aimed to determine if a large-scale, multi-center leaderboard improved simulated CPR practice frequency and CPR performance among healthcare professionals. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.02.050DOI Listing
April 2019
3 Reads
4.167 Impact Factor

Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: An external validation of the HOPE score.

Resuscitation 2019 Mar 30. Epub 2019 Mar 30.

Emergency Department, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Aims: The HOPE score, based on covariates available at hospital admission, predicts the probability of in-hospital survival after extracorporeal life support (ECLS) rewarming of a given hypothermic cardiac arrest patient with accidental hypothermia. Our goal was to externally validate the HOPE score.

Methods: We included consecutive hypothermic arrested patients who underwent rewarming with ECLS. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.017DOI Listing
March 2019
2 Reads

Coronary atherothrombosis in cardiac arrest survivors without ST-segment elevation on ECG.

Resuscitation 2019 Mar 27. Epub 2019 Mar 27.

Department of Cardiology, Cochin University Hospital, AP-HP, Paris Descartes University Sorbonne Paris-Cité, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.resuscitation.2019.01.046DOI Listing
March 2019
1 Read

Associations between cardiopulmonary resuscitation (CPR) knowledge, self-efficacy, training history and willingness to perform CPR and CPR psychomotor skills: A systematic review.

Resuscitation 2019 Mar 27;138:259-272. Epub 2019 Mar 27.

CMD, James Cook University, Australia.

Aim: To determine whether training history (including number of times and duration since last training), knowledge, self-efficacy or willingness are associated with cardiopulmonary resuscitation (CPR) psychomotor skills.

Methods: Eight databases were systematically searched from January 2005 to February 2018 for articles that involved adult layperson participants and explored an association between training history, knowledge, self-efficacy or willingness and CPR psychomotor skills or survival outcomes after real CPR attempts.

Results: Thirty-four articles with a total of 35,421 participants were included. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.019DOI Listing
March 2019
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Improving skills retention after advanced structured resuscitation training: A systematic review of randomized controlled trials.

Resuscitation 2019 Mar 27;138:284-296. Epub 2019 Mar 27.

Department of Anesthesia, University of Toronto, Toronto, ON, Canada; Department of Anesthesiology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

Aims: To systematically evaluate the literature on interventions that improve skills retention following advanced structured resuscitation training programs designed for healthcare professionals.

Methods: A systematic review of MEDLINE, EMBASE, CENTRAL, CINAHL, PsycINFO, ERIC, and Scopus was performed. Only randomized controlled trials investigating skills retention following advanced structured resuscitation training programs for healthcare professionals between inception to November 21, 2018 were included. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.031DOI Listing
March 2019
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Time of on-scene resuscitation in out of-hospital cardiac arrest patients transported without return of spontaneous circulation.

Resuscitation 2019 Mar 27;138:235-242. Epub 2019 Mar 27.

Amsterdam UMC, Academic Medical Center, Heart Center, Department of Cardiology, Meibergdreef 9, Amsterdam, The Netherlands.

Background: In out-of-hospital cardiac arrest (OHCA), return of spontaneous circulation (ROSC) on scene occurs only in a minority of patients. The optimal duration of resuscitation on scene before transport with ongoing cardiopulmonary resuscitation (CPR) is unknown.

Purpose: To determine the time of resuscitation on scene ('time on scene') and survival in patients transported with ongoing CPR in the Netherlands. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.030DOI Listing
March 2019
2 Reads

Cost-effectiveness of public automated external defibrillators.

Resuscitation 2019 Mar 26;138:250-258. Epub 2019 Mar 26.

Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.

Background: Despite a consistent association with improved outcomes, public automated external defibrillators (AEDs) are rarely used in out-of-hospital cardiac arrest. One of the barriers towards increased use might be cost-effectiveness.

Methods: We compared the cost-effectiveness of public AEDs to no AEDs for out-of-hospital cardiac arrest in the United States over a life-time horizon. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.029DOI Listing
March 2019
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Vital sign patterns before shock-related cardiopulmonary arrest.

Resuscitation 2019 Mar 26. Epub 2019 Mar 26.

Arrowhead Regional Medical Center, Department of Emergency Medicine, Colton, CA, United States; Air Methods Corporation, Greenwood Village, Colorado, United States; California University of Science and Medicine, San Bernardino, CA, United States.

Objective: Traditional vital sign thresholds reflect an increased risk of mortality, which may occur hours, days, or weeks following illness/injury, limiting immediate clinical significance to guide rescue therapy to avoid arrest. Our objective is to explore vital sign patterns prior to arrest due to shock.

Design: This retrospective observational analysis utilized physiological data from adult helicopter patients suffering provider-witnessed arrest. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.028DOI Listing
March 2019
9 Reads

Self-learning training versus instructor-led training for basic life support: A cluster randomised trial.

Resuscitation 2019 Mar 26. Epub 2019 Mar 26.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Centre of Registers Västra Götaland, Gothenburg, Sweden; Prehospen-Centre of Prehospital Research, Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Sweden.

Aim: To compare the effectiveness of two basic life support (BLS) training interventions.

Methods: This experimental trial enrolled 1301 lay people in BLS training. The participants were cluster randomised to either self-learning training or to traditional instructor-led training. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.026DOI Listing
March 2019
1 Read