25,012 results match your criteria Restrictive Lung Disease


Tobacco and cannabis co-use and interrelatedness among adults.

Addict Behav 2018 Nov 27;90:354-361. Epub 2018 Nov 27.

Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston, SC, USA.

Cannabis and tobacco co-use is prevalent, but consensus regarding the reasons for co-use among adults and the degree of interrelatedness between these substances is lacking. Reasons for co-use have been explored with younger users, but little data exists for more experienced users with entrenched patterns of co-use. The goal of this study was to examine characteristics and patterns of cannabis-tobacco co-use among adults in the Southeastern United States (US), where there is a legal landscape of generally restrictive cannabis legislation coupled with more permissive tobacco control compared to other US regions. Read More

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November 2018
1 Read

Laparoscopic sleeve gastrectomy and gastroesophageal reflux.

Rom J Intern Med 2018 Dec;56(4):227-232

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Read More

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December 2018

Acid-induced Activated Cell Penetrating Peptide Modified Cholesterol-conjugated Polyoxyethylene Sorbitol Oleate Mixed Micelles for pH-triggered Drug Release and Efficient Brain Tumor Targeting Based on a Charge Reversal Mechanism.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Glioblastoma multiforme is the most devastating malignant brain tumor in adults. Even with standard-care of therapy, the prognosis remains dismal due to tumor heterogeneity, tumor infiltration, and more importantly, the restrictive nature of the blood-brain barrier (BBB). To overcome the challenge of effectively delivering therapeutic cargo into the brain, herein a "smart," multifunctional polymeric micelle was developed using a cholesterol-conjugated polyoxyethylene sorbitol oleate. Read More

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December 2018

A qualitative exploration of menstruation-related restrictive practices in Fiji, Solomon Islands and Papua New Guinea.

PLoS One 2018 3;13(12):e0208224. Epub 2018 Dec 3.

Burnet Institute, Melbourne, Victoria, Australia.

Attitudes and beliefs about menstruation can place restrictions on menstruating women and girls, limiting their ability to fully participate in community life, education and employment. This paper presents evidence on menstruation-related beliefs contributing to restrictive practices in Papua New Guinea (PNG), Solomon Islands (SI) and Fiji. Focus group discussions and interviews were undertaken with 307 adolescent girls, women and men in a rural and urban site in each country. Read More

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December 2018

Gender Differences in Smartphone Addiction Behaviors Associated With Parent-Child Bonding, Parent-Child Communication, and Parental Mediation Among Korean Elementary School Students.

J Addict Nurs 2018 Oct/Dec;29(4):244-254

Eun Jee Lee, PhD, RN, College of Nursing, Chonbuk National University, Jeonju, Republic of Korea. Hee Sun Kim, PhD, RN, College of Nursing, Research Institute of Nursing Science, Chonbuk National University, Jeonju, Republic of Korea.

Objective: This study investigated the gender differences in smartphone addiction (SA) behaviors associated with parent-child bonding, parent-child communication, and parental mediation among Korean elementary school students aged 11-13 years.

Method: A sample of 224 smartphone users (112 boys and 112 girls) was surveyed in a cross-sectional study. Descriptive statistics and multiple regression analysis were conducted to investigate the predictors of SA behaviors based on gender differences using SPSS Win 23. Read More

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December 2018

[Bone seeking tracers' scintigraphy for the diagnosis of transthyretin cardiac amyloidosis].

Medicina (B Aires) 2018 ;78(6):395-398

Sección Medicina Nuclear, Servicio de Diagnóstico por Imágenes, Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.

Transthyretin cardiac amyloidosis (ATTR) is a restrictive cardiomyopathy that leads to heart failure in considerable number of patients. Early diagnosis allows specific treatment options. However, ATTR diagnosis is complex and requires invasive procedures. Read More

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January 2018

Defining Athletes and Exercisers.

Am J Cardiol 2018 Nov 6. Epub 2018 Nov 6.

Center for Sports Cardiology, University of Washington, Seattle, Washington.

Current definitions of an athlete range from loosely defined to overly restrictive, rely on qualitative subjective descriptors, and fail to capture the majority of physically active patients. To improve the understanding between exercise and health metrics a more standardized and granular classification of exercising patients is required. We propose a simplified algorithm to categorize and define exercising patients based on the: (1) intent of exercise, (2) volume of exercise (hours/week), and (3) level of competition. Read More

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November 2018

Idiopathic pulmonary fibrosis in West Highland white terriers: An update.

Vet J 2018 Dec 25;242:53-58. Epub 2018 Oct 25.

Department of Clinical Sciences, FARAH, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.

Canine idiopathic pulmonary fibrosis (CIPF) affects middle-aged to older dogs of a single breed, mainly the West Highland white terrier (WHWT), which is suggestive of a genetic predisposition. CIPF causes exercise intolerance, restrictive dyspnoea and coughing. Coarse crackles are heard on thoracic auscultation. Read More

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December 2018

The 3rd Intron of IRF8 Is a Cell-Type Specific Chromatin Priming Element during Mouse Embryonal Stem Cells Differentiation.

J Mol Biol 2018 Nov 28. Epub 2018 Nov 28.

Department of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel. Electronic address:

Interferon Regulatory Factor 8 (IRF8) is a nuclear transcription factor that plays a key role in the hierarchical differentiation of Hematopoietic Stem Cells toward monocyte/dendritic cell (DC) lineages. Therefore, its expression is mainly limited to bone marrow derived cells. The molecular mechanisms governing this cell-type restricted expression have been described. Read More

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November 2018

The hidden health care costs of power of attorney legislation in Scotland: what needs to be done?

J Health Serv Res Policy 2018 Dec 1:1355819618814055. Epub 2018 Dec 1.

Adult Health Services Manager, NHS Greater Glasgow & Clyde, Gartnavel Hospital, UK.

Current power of attorney legislation in many European countries seeks to protect the rights of adult patients who lack capacity by ensuring that discharge from hospital to an alternative care setting only occurs when there is legal authority to do so, via a named guardian or power of attorney. In Scotland, a clause introduced in 2007 allows some patients who lack capacity to be transferred from hospital to a community care service provided all relevant parties are agreed that this is in keeping with the legislation (the 'least restrictive option') and the patient does not resist the move. However, there is variation in the understanding and use of this clause by local authorities across Scotland, often resulting in avoidable hospital delays, which are costly and cause 'bed blocking'. Read More

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December 2018

Working towards least restrictive environments in acute mental health wards in the context of locked door policy and practice.

Int J Ment Health Nurs 2018 Dec 5. Epub 2018 Dec 5.

Melbourne School of Population and Global Health, Centre for Mental Health, The University of Melbourne, Melbourne, Victoria, Australia.

There has been a shift towards provision of mental health care in community-based settings in Australia. However, hospitals continue to care for people in acute mental health wards. An increasing proportion of the people in wards are admitted involuntarily, subject to restrictions of movement to minimize risk of harm to self and others. Read More

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December 2018

Restrictive Intraoperative Fluid Therapy is Associated with Decreased Morbidity and Length of Stay Following Hyperthermic Intraperitoneal Chemoperfusion.

Ann Surg Oncol 2018 Dec 4. Epub 2018 Dec 4.

Division of Surgical Oncology, Department of Surgery, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Recent data have demonstrated multiple benefits of intra- and postoperative fluid restriction in major abdominal surgery; however, data regarding the outcomes of fluid restriction in cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) are limited. This study evaluates the safety and short-term clinical outcomes of restricted intraoperative fluid therapy in CRS/HIPEC.

Methods: This was a single-institution, retrospective review of all CRS/HIPEC procedures performed at the University of Massachusetts Medical School between January 2009 and July 2017. Read More

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December 2018
1 Read

Recessive PYROXD1 mutations cause adult-onset limb-girdle-type muscular dystrophy.

J Neurol 2018 Dec 4. Epub 2018 Dec 4.

Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland.

Objective: To describe adult-onset limb-girdle-type muscular dystrophy caused by biallelic variants in the PYROXD1 gene, which has been recently linked to early-onset congenital myofibrillar myopathy.

Methods: Whole exome sequencing was performed for adult-onset neuromuscular disease patients with no molecular diagnosis. Patients with PYROXD1 variants underwent clinical characterization, lower limb muscle MRI, muscle biopsy and spirometry. Read More

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December 2018
3 Reads
3.380 Impact Factor

Malignant Pleural Effusion: Still A Long Way To Go.

Authors:
Fausto Meriggi

Rev Recent Clin Trials 2018 Dec 3. Epub 2018 Dec 3.

Oncology Department - Poliambulanza Foundation, Brescia. Italy.

Background: Malignant pleural effusion, which is a common clinical problem in patients with cancer, may be due to both primary thoracic tumours or to a metastatic spread in the chest and constitutes the first sign of disease in approximately 10% of patients. Almost all cancers can potentially produce a pleural effusion. The presence of malignant tumour cells in the pleural fluid is generally indicative of advanced disease and is associated with high morbidity and mortality with reduced therapeutic options. Read More

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December 2018

Factors Influencing Georgia Legislators' Decision-Making on Nurse Practitioner Scope of Practice.

Policy Polit Nurs Pract 2018 Dec 4:1527154418817036. Epub 2018 Dec 4.

1 Emory University, Atlanta, GA, USA.

The state of Georgia faces challenges in providing access to care, largely due to rural hospital closures and physician shortages. Although nurse practitioners (NPs) could help address Georgia's urgent health care needs, the state remains restrictive with respect to NP scope of practice (SOP). This study examined factors that influence Georgia legislators' decision-making on NP SOP. Read More

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December 2018

Quality of clinical practice guidelines about red blood cell transfusion.

J Evid Based Med 2018 Dec 3. Epub 2018 Dec 3.

Iberomerican Cochrane Centre, Clinical Epidemiology and Public Health Department, Institute of Biomedical Research (IIB Sant Pau), CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.

Background: Red blood cell (RBC) transfusions are essential in health care. The quality of recommendations included in clinical practice guidelines (CPG), regarding this intervention, has not been systematically evaluated. This paper systematically assessed CPGs for RBC-transfusion, to appraise their methodological quality, to explore changes in quality over time, and to assess the consistency of the hemoglobin threshold (HT) recommendations. Read More

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December 2018
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Restrictive versus liberal red blood cell transfusion for cardiac surgery: a systematic review and meta-analysis of randomized controlled trials.

J Thromb Thrombolysis 2018 Dec 3. Epub 2018 Dec 3.

Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Patients undergoing cardiac surgery are among the most common recipients of allogeneic red blood cell (RBC) transfusions. However, whether restrictive RBC transfusion strategies for cardiac surgery achieve a similar clinical outcome in comparison with liberal strategies remains unclear. We searched electronic databases from inception to December 2017 for randomized controlled trials (RCTs). Read More

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December 2018

Feed Restriction Modulates the Fecal Microbiota Composition, Nutrient Retention, and Feed Efficiency in Chickens Divergent in Residual Feed Intake.

Front Microbiol 2018 19;9:2698. Epub 2018 Nov 19.

Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Vienna, Austria.

There is a great interest to understand the impact of the gut microbiota on host's nutrient use and FE in chicken production. Both chicken's feed intake and gut bacterial microbiota differ between high and low-feed efficient chickens. To evaluate the impact of the feed intake level on the feed efficiency (FE)-associated variation in the chicken intestinal microbiota, differently feed efficient chickens need to eat the same amount of feed, which can be achieved by feeding chickens restrictively. Read More

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November 2018
1 Read

A User's Guide for Surgery Involving the Artificial Urinary Sphincter.

Sex Med Rev 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA. Electronic address:

Introduction: The artificial urinary sphincter (AUS) has long been regarded as the gold standard for surgical correction of male stress urinary incontinence (SUI). Despite impressive rates of initial success for restoration of continence, durability may wane to the point of considering revision surgery.

Aim: To provide a review of existing data as well as personal experience regarding patient selection, surgical technique, and postoperative troubleshooting for the AUS. Read More

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November 2018

Can professional football clubs deliver a weight management programme for women: a feasibility study.

BMC Public Health 2018 Dec 3;18(1):1330. Epub 2018 Dec 3.

Institute of Health and Wellbeing, College of Social Science, University of Glasgow, Glasgow, UK.

Background: Levels of obesity remain high in the UK. The Football Fans in Training (FFIT) randomised controlled trial (RCT) demonstrated that a 12-week, gender-sensitised weight management, physical activity and healthy eating group programme delivered through professional football clubs helped men aged 35-65 years with BMI at least 28 kg/m lose a clinically-significant amount of weight. We aimed to test the feasibility of a minimally-adapted FFIT programme for delivery to women by assessing recruitment and completion rates; determining if the programme content and delivery required further refinement; and evaluating the potential of FFIT for Women to deliver improvements in weight and other clinical, behavioural and psychological outcomes. Read More

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December 2018
2 Reads

Association of Lung Function with Serum 25-Hydroxyvitamin D Level according to the Presence of Past Pulmonary Tuberculosis in Korean Adults.

Korean J Fam Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Family Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Vitamin D deficiency is associated with an increased risk of pulmonary tuberculosis (PTB) infection and the treatment outcome. The aim of this study was to examine the relationship between the serum 25-hydroxyvitamin D (25[OH]D) level and lung function in Korean adults according to whether or not there is a history of PTB.

Methods: The data for subjects aged 19 years or older from the Korea National Health and Nutrition Examination Survey 2008-2012 who underwent spirometry, chest radiography, and serum 25(OH)D level measurement were analyzed. Read More

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December 2018

Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016.

JAMA Pediatr 2018 Nov 30. Epub 2018 Nov 30.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Acute flaccid myelitis (AFM) is an emerging poliolike illness of children whose clinical spectrum and associated pathogens are only partially described. The case definition is intentionally encompassing for epidemiologic surveillance to capture all potential AFM cases. Defining a restrictive, homogenous subpopulation may aid our understanding of this emerging disease. Read More

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November 2018
1 Read

Therapeutic nanoplatforms and delivery strategies for neurological disorders.

Nano Converg 2018 Nov 30;5(1):35. Epub 2018 Nov 30.

Department of Mechanical Engineering and Engineering Science, Center for Biomedical Engineering and Science, Department of Biological Sciences, The Nanoscale Science Program, University of North Carolina at Charlotte, Charlotte, NC, USA.

The major neurological disorders found in a central nervous system (CNS), such as brain tumors, Alzheimer's diseases, Parkinson's diseases, and Huntington's disease, have led to devastating outcomes on the human public health. Of these disorders, early diagnostics remains poor, and no treatment has been successfully discovered; therefore, they become the most life-threatening medical burdens worldwide compared to other major diseases. The major obstacles for the drug discovery are the presence of a restrictive blood-brain barrier (BBB), limiting drug entry into brains and undesired neuroimmune activities caused by untargeted drugs, leading to irreversible neuronal damages. Read More

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November 2018
3 Reads

Mortality, Morbidity and Related Outcomes Following Perioperative Blood Transfusion in Patients with Major Orthopaedic Surgery: A Systematic Review.

Transfus Med Hemother 2018 Oct 28;45(5):355-367. Epub 2018 Feb 28.

Division Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institut, Langen, Germany.

Background: Benefits and risks of liberal and restrictive transfusion regimens are under on-going controversial discussion. This systematic review aimed at assessing both regimens in terms of pre-defined outcomes with special focus on patients undergoing major orthopaedic surgery.

Methods: We performed a literature search for mortality, morbidity and related outcomes following peri-operative blood transfusion in patients with major orthopaedic surgery in electronic databases. Read More

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October 2018
2 Reads

A systematic scoping review of diagnostic validity in avoidant/restrictive food intake disorder.

Int J Eat Disord 2018 Nov 29. Epub 2018 Nov 29.

Stockholm Centre for Eating Disorders, Stockholm, Sweden.

Objective: Avoidant/restrictive food intake disorder (ARFID) was introduced as a new diagnosis in the DSM-5. This systematic scoping review explores how ARFID as a diagnostic entity is conceptualized in the research literature and evaluates the diagnostic validity according to the Feighner criteria.

Method: A systematic scoping review of papers on ARFID in PubMed/MEDLINE and Web of Science was undertaken, following PRISMA and Joanna Briggs Institute guidelines. Read More

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November 2018
1 Read

Weight restoration in atypical anorexia nervosa: A clinical conundrum.

Int J Eat Disord 2018 Nov 28. Epub 2018 Nov 28.

Division of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, California.

The determination of the treatment goal weight for adolescents with a restrictive eating disorder (ED) and a prior history of obesity, such as in atypical anorexia nervosa (AAN), represents an ongoing challenge for clinicians. This determination is particularly complex given competing interests of physical recovery from significant weight loss, mental recovery from ED psychopathology, and the medical comorbidities associated with obesity. We report the case of a 15-year old female with a history of obesity and irregular periods who presented with significant weight loss and absence of menses for 3 months. Read More

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November 2018
1 Read

Safety and Efficacy of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Used for Analgesia After Bariatric Surgery: A Retrospective Case-Control Study.

Obes Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Anesthesia, Crtitical Care and Pain Management, Hôtel Dieu de France hospital, Saint Joseph university school of medicine, P.O.Box 11-5076, Beirut, 1107 2180, Lebanon.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are cornerstone in multimodal analgesia protocols. This point is of great value in morbidly obese patients due to the high prevalence of restrictive pulmonary disease and obstructive sleep apnea. The aim of this study was to test the hypothesis that NSAIDs do not increase acute bariatric surgery complications while optimizing postoperative analgesia. Read More

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November 2018
4 Reads

Warning labels on fashion images: Short- and longer-term effects on body dissatisfaction, eating disorder symptoms, and eating behavior.

Int J Eat Disord 2018 Nov 27. Epub 2018 Nov 27.

Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Objective: Fashion warning labels that caution readers about digitally altered images have been recommended and adopted by several countries to prevent body dissatisfaction and eating disorders. This study investigated the short- and longer-term influence of fashion warning labels on affect, body dissatisfaction, eating disorder symptoms, and snack consumption using a randomized-controlled experiment.

Method: Female undergraduates (n = 118) were randomized to view and rate responses to fashion images either with or without a warning label. Read More

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November 2018
4 Reads

The Evolution of Glaucoma Drainage Implants.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):498-500

Department of Ophthalmology, University of Virginia, School of Medicine, Charlottesville, Virginia, USA.

The modern glaucoma drainage implant era was initiated with implantation of a plate posterior to the limbus connected to the anterior chamber by a long silicone tube. Non-restrictive (Molteno and Baerveldt implants) and flow-restrictive (Ahmed Glaucoma Valve) implants were developed. With increased clinical experience, variables influencing success and failure of glaucoma drainage implant surgery were better understood. Read More

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November 2018

Coverage of Novel Therapeutic Agents by Medicare Prescription Drug Plans Following FDA Approval.

J Manag Care Spec Pharm 2018 Dec;24(12):1230-1238

3 Robert Wood Johnson Foundation Clinical Scholars Program and Section of General Internal Medicine, Department of Internal Medicine, Yale School of Medicine; Department of Health Policy and Management, Yale School of Public Health; and Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut.

Background: Regulatory approval of novel therapies by the FDA does not guarantee insurance coverage requisite for most clinical use. In the United States, the largest health insurance payer is the Centers for Medicare & Medicaid Services (CMS), which provides Part D prescription drug benefits to over 43 million Americans. While the FDA and CMS have implemented policies to improve the availability of novel therapies to patients, the time required to secure Medicare prescription drug benefit coverage-and accompanying restrictions-has not been previously described. Read More

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December 2018
2 Reads

Timing of Parents' Concerns Related to Autism Spectrum Disorder and its Diagnosis: A Mediation Analysis.

Span J Psychol 2018 Nov 27;21:E59. Epub 2018 Nov 27.

Universidad de Granada (Spain).

Parents are the first to indicate concerns about their child's development in up to 80% of children with autism spectrum disorder (ASD). They often notice symptoms related to ASD around the first two years, but the average age of diagnosis is 3.5 years old. Read More

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November 2018

Less Data Same Information for Event-Based Sensors: A Bioinspired Filtering and Data Reduction Algorithm.

Sensors (Basel) 2018 Nov 24;18(12). Epub 2018 Nov 24.

Group for Digital Design and Processing, Department of Electronic Engineering, School of Engineering, Universitat de Valencia, Burjassot, 46100 Valencia, Spain.

Sensors provide data which need to be processed after acquisition to remove noise and extract relevant information. When the sensor is a network node and acquired data are to be transmitted to other nodes (e.g. Read More

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November 2018

The Mini-Gastric Bypass Original Technique.

Int J Surg 2018 Nov 23. Epub 2018 Nov 23.

Department of Surgery, Kular Hospital Pvt. Ltd., National Highway 1, Bija, Khanna, Ludhiana, Punjab, 141412, India. Electronic address:

Introduction: Mini-Gastric Bypass (MGB) is becoming more and more popular as shown by the numerous articles published over the past 15 years, supporting the operation as a short and simple procedure with excellent outcomes and low complication rates. There is still confusion amongst surgeons on the technique of the operation. The purpose of this paper is to review and describe the technique of MGB by its originators. Read More

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November 2018
1 Read

Combination long-acting injectable (LAI) antipsychotic medication in adolescents with severe psychosis and aggression: a case series.

Australas Psychiatry 2018 Nov 26:1039856218815744. Epub 2018 Nov 26.

Consultant Forensic, Child and Adolescent Psychiatrist, Adolescent Unit, The Forensic Hospital, Matraville, NSW, and; Conjoint Senior Lecturer, School of Psychiatry, University of New South Wales, Sydney, NSW, Child and Adolescent Mental Health Service, ACT Health, Sydney, NSW, and; Visiting Fellow, Centre for Mental Health Research, Australian National University, Canberra, ACT, and; The Level 8 Practice, Sydney, NSW, Australia.

Objectives:: We examine the use of combination long-acting injectable (LAI) antipsychotic medication for adolescents with severe psychosis and aggression. We discuss benefits and risks with this approach, for a highly challenging small group of young people.

Methods:: A clinical summary is given of three adolescents admitted to a secure adolescent forensic inpatient unit, and the literature is reviewed. Read More

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November 2018
1 Read

Assessment of Respiratory Symptoms and Pulmonary Function Status among Workers of Flour Mills in Addis Ababa, Ethiopia: Comparative Cross-Sectional Study.

Pulm Med 2018 24;2018:9521297. Epub 2018 Oct 24.

Addis Ababa University College of Medicine and Health Sciences, Department of Physiology, Addis Ababa, Ethiopia.

Background: Flour dust in the respiratory tract affects lung function. Flour dust is a heterogeneous organic substance which can have a tendency to cause respiratory ailments. There is growing consensus on the deleterious effects of flour dust on respiratory symptoms and lung performance of flour mill workers. Read More

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October 2018
1 Read

Understanding the full burden of drowning: a retrospective, cross-sectional analysis of fatal and non-fatal drowning in Australia.

BMJ Open 2018 Nov 24;8(11):e024868. Epub 2018 Nov 24.

Royal Life Saving Society-Australia, Broadway, New South Wales, Australia.

Objectives: The epidemiology of fatal drowning is increasingly understood. By contrast, there is relatively little population-level research on non-fatal drowning. This study compares data on fatal and non-fatal drowning in Australia, identifying differences in outcomes to guide identification of the best practice in minimising the lethality of exposure to drowning. Read More

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November 2018
4 Reads

[Medium and long-term respiratory outcome in patients operated from congenital diaphragmatic hernia: From a series of 56 patients].

Rev Pneumol Clin 2018 Nov 22. Epub 2018 Nov 22.

Service de pédiatrie et CRCM, pôle médicochirurgical de pédiatrie, CHU de Strasbourg, hôpital de Hautepierre, Strasbourg, France.

Introduction: Recent advances in prenatal diagnosis, high frequency oscillatory ventilation and pulmonary arterial hypertension (PAH) therapies have progressively improved the survival of patients with congenital diaphragmatic hernia (CDH). However, CDH is associated with high morbidity that affects about half of surviving children. The main sequelae observed are respiratory (asthma, persistent PAH [PPAH], bronchopulmonary dysplasia, respiratory infections) and digestive (gastroesophageal reflux disease [GERD]). Read More

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November 2018
1 Read

Headache in Pregnancy and the Puerperium.

Authors:
Rebecca Burch

Neurol Clin 2019 Feb;37(1):31-51

Department of Neurology, John R. Graham Headache Center, Brigham and Women's Hospital, Harvard Medical School, 1153 Centre Street, Suite 4H, Jamaica Plain, Boston, MA 02130, USA. Electronic address:

Migraine is the most common cause of headache during pregnancy. Pregnancy increases risk for many causes of headache, including pathologic vascular processes. Headache associated with neurologic signs or symptoms or that is progressive and refractory to treatment; acute in onset; and severe, postural, or different from typical headaches should be evaluated. Read More

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February 2019
2 Reads

Intraoperative relaxed muscle positioning technique results in a tertiary Center for Thyroid Orbitopathy Related Strabismus.

BMC Ophthalmol 2018 Nov 23;18(1):305. Epub 2018 Nov 23.

Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Cerrahpasa School of Medicine, 34098, Fatih, Istanbul, Turkey.

Background: Previous techniques resulted with low rates of successful fusion after the surgeries and high necessity of additional surgeries in the treatment of thyroid orbitopathy related strabismus. In this study, reviewing the results of our patients who had surgical correction with relaxed muscle positioning technique due to thyroid orbitopathy related strabismus to evaluate the effectiveness of the surgery was aimed.

Methods: The medical records of 8 patients who had surgical correction with intraoperative relaxed muscle positioning (IRMP) technique were studied retrospectively. Read More

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November 2018

A parent-oriented alcohol prevention program "Effekt" had no impact on adolescents' alcohol use: Findings from a cluster-randomized controlled trial in Estonia.

Drug Alcohol Depend 2018 Nov 14;194:279-287. Epub 2018 Nov 14.

Behavioural Science Group, Primary Care Unit, Institute of Public Health, Forvie Site, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0SR, United Kingdom. Electronic address:

Aim: To evaluate the effectiveness of a universal parent-oriented alcohol prevention program ("Effekt") in Estonia. The main objective of the program was to delay and reduce adolescents' alcohol consumption by maintaining parental restrictive attitudes towards adolescents' alcohol use over time.

Methods: A matched-pair cluster randomized controlled trial with a three-year assessment period (baseline (T1), 18-months (T2) and 30-months (T3) follow-ups) was undertaken in 2012-2015 among 985 fifth grade adolescents and 790 parents in sixty-six schools (34 intervention, 32 control). Read More

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November 2018
1 Read

Potential molecular targets of peroxynitrite in mediating blood-brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment.

Free Radic Res 2018 Nov 23:1-20. Epub 2018 Nov 23.

a School of Chinese Medicine , the University of Hong Kong , PR China.

Tissue plasminogen activator (t-PA) remains to be the only FDA-approved drug for ischaemic stroke, but it has a restrictive therapeutic window with 4.5 hours. Beyond the golden time window, thrombolytic treatment carries the risk of haemorrhagic transformation (HT). Read More

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November 2018
4 Reads

Living 'in between' outside and inside: The forensic psychiatric unit as an impermanent assemblage.

Health Place 2018 Nov 19. Epub 2018 Nov 19.

Division of Psychology, London South Bank University, United Kingdom. Electronic address:

This paper presents analysis from 'a study of staff and patient experiences of the restrictive environments of a forensic psychiatric unit. The paper conceptualises the forensic unit as an impermanent assemblage, enacted in and through practices that hold a future life outside the unit simultaneously near, yet far. We show how the near-far relations between life inside and outside the unit operate in three ways; 1) in relation to the 'care pathway', 2) practices of dwelling, and 3) creating and maintaining connections to life 'beyond' the unit. Read More

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November 2018
3 Reads

Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction.

J Heart Lung Transplant 2018 Oct 31. Epub 2018 Oct 31.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine; Duke Clinical Research Institute.

Background: Chronic lung allograft dysfunction (CLAD), including the phenotypes of bronchiolitis obliterans syndrome (BOS) and restrictive CLAD (R-CLAD), represents the leading cause of late death after lung transplantation. Little is known, however, regarding the natural history or prognostic significance of pulmonary function changes after the onset of these conditions. We examined changes in forced expiratory volume in 1 second (FEV) and forced vital capacity (FVC) over the first 18 months after CLAD. Read More

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October 2018
4 Reads

Who Should Be Gluten-Free? A Review for the General Practitioner.

Med Clin North Am 2019 Jan 1;103(1):89-99. Epub 2018 Nov 1.

Department of Internal Medicine, Division of Digestive and Liver Diseases, University of Texas Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390-9151, USA. Electronic address:

Historically, a gluten-free diet was recommended only for those with celiac disease or IgE-mediated wheat allergy. With changes in food allergy labeling in the United States and the publication of several best-selling books, gluten-related disorders have come to the forefront of popular culture. As a result, there has been a dramatic increase in the number of gluten-free diet followers, many for nontraditional reasons. Read More

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January 2019
1 Read

Successful recruitment and retention strategies for women health volunteers: viewpoints of the volunteers' supervisors and relevant researchers.

J Multidiscip Healthc 2018 26;11:621-634. Epub 2018 Oct 26.

Department of Health Education and Promotion, Faculty of Health Sciences, Tabriz University of Medical Sciences, Tabriz, Iran,

Background: Women health volunteers (WHVs) are a link between people and healthcare workers. Despite their key role in promoting community health, strategies are rarely designed to keep them volunteering. The aim of this research was to find successful strategies to overcome barriers to recruitment and retention of the volunteers in assigned activities. Read More

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October 2018
2 Reads

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.

J Cell Biol 2018 Nov 21. Epub 2018 Nov 21.

Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL

Vascular endothelial (VE)-cadherin forms homotypic adherens junctions (AJs) in the endothelium, whereas N-cadherin forms heterotypic adhesion between endothelial cells and surrounding vascular smooth muscle cells and pericytes. Here we addressed the question whether both cadherin adhesion complexes communicate through intracellular signaling and contribute to the integrity of the endothelial barrier. We demonstrated that deletion of N-cadherin () in either endothelial cells or pericytes increases junctional endothelial permeability in lung and brain secondary to reduced accumulation of VE-cadherin at AJs. Read More

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November 2018
6 Reads