4,463 results match your criteria Restrictive Lung Disease


Pulmonary Hypertension in Patients with Common Variable Immunodeficiency.

J Clin Immunol 2021 Jun 10. Epub 2021 Jun 10.

Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Purpose: Common variable immunodeficiency (CVID) is known to cause infectious, inflammatory, and autoimmune manifestations. Pulmonary hypertension (PH) is an unusual complication of CVID with largely unknown characteristics and mechanisms.

Methods: We report the clinical, functional, hemodynamics, radiologic and histologic characteristics, and outcomes of CVID-associated PH patients from the French PH Network. Read More

View Article and Full-Text PDF

Patients' perceptions of orthodontic treatment experiences during COVID-19: a cross-sectional study.

Prog Orthod 2021 Jun 8;22(1):17. Epub 2021 Jun 8.

Division of Orthodontics, University of Connecticut Health, 263 Farmington Ave, Farmington, CT, 06032, USA.

Background: COVID-19 has impacted the care of patients undergoing orthodontic treatment. We aimed to provide an overall view of patients' perspectives, concerns, and expectations towards their treatment throughout the clinic lockdown during the pandemic; and to assess patients' levels of mental distress and its association with their confidence in resuming care.

Methods: An anonymous, validated, in-person paper questionnaire was distributed to adult orthodontic patients' post-lockdown at an academic institution. Read More

View Article and Full-Text PDF

Ethics-driven policy framework for implementation of movement restrictions in pandemics.

BMJ Glob Health 2021 06;6(6)

Association for Socially Applicable Research, Pune, India.

In the ongoing COVID-19 pandemic, countries across the globe undertook several stringent movement restrictions to prevent the virus spread. In April 2020, around 3.9 billion people in 90 countries were contained in their homes. Read More

View Article and Full-Text PDF

Organisation and timeline of measures in French psychiatric establishments during the first wave of the COVID-19 epidemic: EvOlu'Psy study.

BMC Psychiatry 2021 06 2;21(1):284. Epub 2021 Jun 2.

Association Hospitalière Sainte-Marie, Centre Hospitalier Sainte-Marie de Clermont-Ferrand, 33 Rue Gabriel Péri, 63000, Clermont-Ferrand, France.

Background: The onset of COVID-19 required rapid organisational changes in the mental health domain. Most mental health-care departments appear to have set up infection control measures and also organised planning, coordination and measures that enabled them to provide psychiatric care in a restrictive environment. Our objective was to assess the organisation by psychiatric facilities in France of their response to COVID-19, during the first wave. Read More

View Article and Full-Text PDF

Health-Related Quality of Life and Experiences of Brazilian Celiac Individuals over the Course of the Sars-Cov-2 Pandemic.

Nutrients 2021 May 9;13(5). Epub 2021 May 9.

Department of Nutrition, School of Health Sciences, University of Brasilia, 70910-900 Brasilia, Brazil.

Since the end of 2019, the world has been facing an unpredicted COVID-19 pandemic with consequences for the economy, environment, society, and health. The COVID-19 pandemic has increased the risk of death, bringing unbearable psychological pressure upon people worldwide. For celiac patients, the pandemic may represent an additional burden concerning the inherent aspects of celiac disease (CD) that compromise these individuals' quality of life (QoL). Read More

View Article and Full-Text PDF

Older Adolescents Who Did or Did Not Experience COVID-19 Symptoms: Associations with Mental Health, Risk Perception and Social Connection.

Int J Environ Res Public Health 2021 May 9;18(9). Epub 2021 May 9.

Department of Psychology, Sapienza University of Rome, Via dei Marsi 78, 00185 Rome, Italy.

After a decrease in detected cases in the summer, Europe faced the emergence of a second wave of coronavirus disease 19 (COVID-19). Few studies have investigated adolescents, who may constitute a target group with possible lower compliance to public health measures, particularly the social distancing measures. A total sample of 492 participants was included in the study, and the ages of the participants ranged from 18-24 years. Read More

View Article and Full-Text PDF

Respiratory Dysfunctions in Parkinson's Disease Patients.

Brain Sci 2021 May 4;11(5). Epub 2021 May 4.

Department of Neurology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Respiratory dysfunctions have been associated with Parkinson's disease since the first observations of the disease in 1817. Patients with Parkinson's disease frequently present respiratory disorders with obstructive ventilatory patterns and restrictive modifications, as well as limitations in respiratory volumes. In addition, respiratory impairments are observed due to the rigidity and kyphosis that Parkinson's disease patients experience. Read More

View Article and Full-Text PDF

The Presumed Influence of COVID-19 Misinformation on Social Media: Survey Research from Two Countries in the Global Health Crisis.

Int J Environ Res Public Health 2021 05 21;18(11). Epub 2021 May 21.

Department of Communication, North Carolina State University, Raleigh, NC 27695, USA.

While the coronavirus 2019 (COVID-19) pandemic is spreading all over the world, misinformation, without prudent journalistic judgments of media content online, has begun circulating rapidly and influencing public opinion on social media. This quantitative study intends to advance the previous misinformation research by proposing and examining a theoretical model following an "influence of presumed influence" perspective. Two survey studies were conducted on participants located in the United States (N = 1793) and China (N = 504), respectively, to test the applicability of the influence of presumed influence theory. Read More

View Article and Full-Text PDF

COVID-19 in advanced Duchenne/Becker muscular dystrophy patients.

Neuromuscul Disord 2021 Apr 6. Epub 2021 Apr 6.

Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel; Department of Pediatrics B, Schneider Children's Medical Center, Petah-Tikva, Israel; Pediatric Infectious Disease Unit, Schneider Children's Medical Center.

Duchenne muscular dystrophy (DMD) is the most common childhood muscular dystrophy. As a result of progressive muscle weakness, pulmonary function decreases during the second decade of life and lung disease contributes significantly to morbidity and mortality in these patients. Corticosteroids are the current standard of care for patients with DMD, despite known adverse effects such as obesity and immunosuppression. Read More

View Article and Full-Text PDF

Chest Dynamic-Ventilatory Digital Radiography in Chronic Obstructive or Restrictive Lung Disease.

Int J Chron Obstruct Pulmon Dis 2021 18;16:1393-1399. Epub 2021 May 18.

Kanazawa University Hospital, Respiratory Medicine, Ishikawa, Japan.

Objective: The aim of this study was to identify the relationships between parameters obtained from dynamic-ventilatory digital radiography (DR) and ventilatory disorders.

Methods: This study comprised 273 participants with respiratory diseases who underwent spirometry and functional residual capacity measurements (104 with normal findings on spirometry as controls, 139 with an obstructive lung disorder, 30 with a restrictive lung disorder) were assessed by dynamic-ventilatory DR. Sequential chest radiography images of the patient's slow and maximum breathing were captured at 15 frames per second by a dynamic flat-panel imaging system. Read More

View Article and Full-Text PDF

Evaluation of the Parameters Affecting Respiratory Functions at Adolescent Idiopathic Scoliosis Patients.

Clin Spine Surg 2021 May 26. Epub 2021 May 26.

Department of Orthopedics and Traumatology, Ministry of Health Metin Sabanci Baltalimani Bone Diseases Training and Research Hospital, Istanbul, Turkey.

Study Design: This was a retrospective observational study.

Objective: The objective of the study was to evaluate the spinal and extraspinal factors responsible for pulmonary dysfunction in adolescent idiopathic scoliosis patients.

Summary Of Background Data: Development of thoracic deformity due to scoliosis results with the restrictive ventilatory pattern and the reduced pulmonary function. Read More

View Article and Full-Text PDF

The Lung Allocation Score and Its Relevance.

Semin Respir Crit Care Med 2021 Jun 24;42(3):346-356. Epub 2021 May 24.

Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, Michigan Medicine/University of Michigan School of Medicine, Ann Arbor, Michigan.

Lung transplantation in the United States, under oversight by the Organ Procurement Transplantation Network (OPTN) in the 1990s, operated under a system of allocation based on location within geographic donor service areas, wait time of potential recipients, and ABO compatibility. On May 4, 2005, the lung allocation score (LAS) was implemented by the OPTN Thoracic Organ Transplantation Committee to prioritize patients on the wait list based on a balance of wait list mortality and posttransplant survival, thus eliminating time on the wait list as a factor of prioritization. Patients were categorized into four main disease categories labeled group A (obstructive lung disease), B (pulmonary hypertension), C (cystic fibrosis), and D (restrictive lung disease/interstitial lung disease) with variables within each group impacting the calculation of the LAS. Read More

View Article and Full-Text PDF

Mortality risk attributable to classification of chronic obstructive pulmonary disease and reduced lung function: A 21-year longitudinal cohort study.

Respir Med 2021 May 15;184:106471. Epub 2021 May 15.

Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China; Shenzhen Research Institute of the Chinese University of Hong Kong, Shenzhen, China. Electronic address:

Aim: The mortality risk attributable to the classifications of chronic obstructive pulmonary disease (COPD) remains unclear. We investigated the associations of mortality with COPD classifications and reduced lung function in a large longitudinal cohort in Taiwan.

Methods: A total of 388,401 adults (≥25 years of age) were recruited between 1996 and 2016 underwent 834,491 medical examinations including spirometry. Read More

View Article and Full-Text PDF

Lung function impairment and cardiometabolic risks among rural adults: implication for an aging society.

BMC Public Health 2021 05 20;21(1):960. Epub 2021 May 20.

Department of Cardiology, Chang Gung Memorial Hospital, No. 2, Chiapu Rd. West Sec, Putz City, 61363, Chiayi, Taiwan, ROC.

Background: Early detection and prevention of cardiometabolic risk factors in an increasingly aging society are a global public health concern. Maintaining adequate lung function is important for healthy aging. Few studies exist on lung function impairment and decline in primary healthcare settings, especially among rural adults with cardiometabolic risks. Read More

View Article and Full-Text PDF

Airway Compliance Measurements in Mouse Models of Respiratory Diseases.

Am J Physiol Lung Cell Mol Physiol 2021 05 19. Epub 2021 May 19.

Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States.

The quantification of airway compliance (C) is essential to the study of airway alterations in disease models. However, the required measurements of airway pressure and volume are difficult to acquire in mice. We hypothesized that the inflation limb of full-range pressure-volume (PV) curves could be used to quantify C, as it contains a segment where only the airway tree is distended. Read More

View Article and Full-Text PDF

A Multiplex One-Step RT-qPCR Protocol to Detect SARS-CoV-2 in NP/OP Swabs and Saliva.

Curr Protoc 2021 May;1(5):e145

Department of Pathology, University of Illinois at Chicago, Chicago, Illinois.

Since December 2019, SARS-CoV-2 has spread extensively throughout the world, with more than 117 million reported cases and 2.6 million deaths (Johns Hopkins coronavirus resource center, https://coronavirus.jhu. Read More

View Article and Full-Text PDF

Impact on neurosurgical management in Level 1 trauma centers during COVID-19 shelter-in-place restrictions: The Santa Clara County experience.

J Clin Neurosci 2021 Jun 4;88:128-134. Epub 2021 Apr 4.

Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, CA 94305, USA; Department of Neurosurgery, Santa Clara Valley Medical Center, 751 S Bascom Ave, San Jose, CA 95128, USA. Electronic address:

Early COVID-19-targeted legislations reduced public activity and elective surgery such that local neurosurgical care greatly focused on emergent needs. This study examines neurosurgical trauma patients' dispositions through two neighboring trauma centers to inform resource allocation. We conducted a retrospective review of the trauma registries for two Level 1 Trauma Centers in Santa Clara County, one academic and one community center, between February 1st and April 15th, 2018-2020. Read More

View Article and Full-Text PDF

Critical analysis of spirometric patterns in correlation to chest computed tomography among adult indigenous Australians with chronic airway diseases.

Expert Rev Respir Med 2021 May 14. Epub 2021 May 14.

University of Sousse, Farhat HACHED Hospital, Heart Failure Research Laboratory (LR12SP09), Sousse, Tunisia.

: There is sparse literature evidence in the spirometric patterns of adult Indigenous Australians with and without chest computed tomography (CT) proven chronic airway diseases (CADs).: Participants spirometry testing graded as acceptable for quality and had a chest CT scan showing radiographic evidence of CADs were included for analysis.: Of the 1350 spirometric tests performed between 2012 and 2020, a total of 214 patients with a mean age of 53 years and 54% females were eligible to be included. Read More

View Article and Full-Text PDF

Relationship between rheumatoid arthritis and pulmonary function measures on spirometry in the UK Biobank.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA.

Objective: We investigated the independent relationship of rheumatoid arthritis (RA) with type and severity of pulmonary patterns on spirometry compared to general population controls.

Methods: This cross-sectional study investigated the association of RA and pulmonary function measures on spirometry among subjects who had spirometry performed for research purposes in the UK Biobank. RA cases were identified by self-report and current DMARD/glucocorticoid use. Read More

View Article and Full-Text PDF

Health literacy and changes in pattern of drug use among participants at the Stockholm Needle Exchange Program during the COVID-19 pandemic.

Harm Reduct J 2021 05 10;18(1):52. Epub 2021 May 10.

Stockholm Needle Exchange, Stockholm Centre for Dependency Disorders, Stockholm, Sweden.

Background And Aims: People who inject drugs may be particularly vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to underlying health problems, stigma and social vulnerabilities. Harm reduction services, including needle exchange programs (NEP), have been subjected to varying degrees of disruption in the world, especially in the beginning of the coronavirus disease 2019 (COVID-19) pandemic. Compared to responses in other countries, Sweden's initial strategy toward limiting the spread and impact of COVID-19 was less restrictive to its citizens with no imposed general societal lockdown. Read More

View Article and Full-Text PDF

The Psychological Impact of COVID-19 Among Pakistani Adults in Lahore.

Front Public Health 2021 21;9:578366. Epub 2021 Apr 21.

Department of Psychology, Forman Christian College: A Chartered University, Lahore, Pakistan.

In the wake of the worldwide spread of the novel coronavirus and the resultant restrictive measures, mental health has become a crucial issue. Physical health is not the only aspect of humans that is at risk. Globally, the rates and severity of mental illness are being significantly impacted by this pandemic. Read More

View Article and Full-Text PDF

Benefits of Continuous Positive Airway Pressure (CPAP) During Radiation Therapy: A Prospective Trial.

Int J Radiat Oncol Biol Phys 2021 May 5. Epub 2021 May 5.

Department of Radiation Oncology, Chaim Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Purpose: This study aimed to study the impact of continuous positive airway pressure (CPAP) on chest anatomy and tumor motion in patients receiving radiation therapy.

Methods And Materials: Patients with primary or secondary lung tumors, left-sided breast cancer, or liver metastases referred for radiation therapy were trained to breathe with a CPAP device using a face mask to a maximal pressure of 15 cm HO. Three- and 4-dimensional computed tomography simulation was performed twice for each patient: once with free breathing (FB) and again using CPAP. Read More

View Article and Full-Text PDF

Persistent Dyspnea in a 74-Year-Old Man With Normal Spirometry and Lung Volumes.

Chest 2021 May;159(5):e303-e307

Department of Pulmonary and Critical Care, Albany Medical Center, NY.

Case Presentation: A 74-year-old man was referred to a pulmonologist for evaluation of a 1-year history of nonproductive cough and progressive exertional dyspnea. He was initially evaluated by his primary care physician, where he had spirometry that was negative for any obstructive or restrictive lung disease. An echocardiogram showed a normal left ventricular ejection fraction, with no wall motion abnormality or valvular heart disease. Read More

View Article and Full-Text PDF

The contribution of patients' lung function to the inspiratory airflow rate achievable through a DPIs' simulator reproducing different intrinsic resistance rates.

Multidiscip Respir Med 2021 Jan 15;16(1):752. Epub 2021 Apr 15.

AdRes Health Economics and Outcome Research, Turin, Italy.

Background: The performance of DPIs depends on several physiological (patient-dependent) and technological (device-dependent) factors. The inspiratory airflow rate is the only active force generated and operating in the system for inducing the required pressure drop and eliciting the resistance-induced turbulence needed to disaggregate the powder through the device. The present study aimed to investigate in the most prevalent respiratory disorders whether and at what extent the inspiratory airflow rate achievable when inhaling through a DPIs' simulator reproducing different intrinsic resistance regimens (low, mid, and high resistance) is affected by peculiar changes in lung function and/or can be predicted by any specific lung function parameter. Read More

View Article and Full-Text PDF
January 2021

Advanced Stages and Increased Need for Adjuvant Treatments in Breast Cancer Patients: The Effect of the One-year COVID-19 Pandemic.

Anticancer Res 2021 May;41(5):2689-2696

Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy.

Background/aim: The COVID-19 lockdown includes restrictive measures and temporary health system reorganization. Resources were shifted to COVID-19 patients, screening programs were temporary suspended, and oncological care suffered slow-down. The aim of the study was to evaluate the impact of these measures on breast cancer patients. Read More

View Article and Full-Text PDF

Well-Being of Healthcare Workers and the General Public during the COVID-19 Pandemic in Vietnam: An Online Survey.

Int J Environ Res Public Health 2021 04 29;18(9). Epub 2021 Apr 29.

Institute for Community Health Research, University of Medicine and Pharmacy, Hue University, Hue 530000, Vietnam.

The COVID-19 pandemic and associated restrictive measures implemented may considerably affect people's lives. This study aimed to assess the well-being of Vietnamese people after COVID-19 lockdown measures were lifted and life gradually returned to normal. An online survey was organized from 21 to 25 April 2020 among Vietnamese residents aged 18 and over. Read More

View Article and Full-Text PDF

Effect of COVID-19 pandemic decisions on tertiary-level surgical services in Pietermaritzburg, KwaZulu-Natal Province, South Africa.

S Afr Med J 2020 12 14;111(2):120-123. Epub 2020 Dec 14.

Discipline of Anaesthesiology and Critical Care, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Background: The COVID-19 pandemic has led to the implementation of restrictive policies on theatre procedures, with profound impacts on service delivery and theatre output.

Objectives: To quantify these effects at a tertiary hospital in KwaZulu-Natal Province, South Africa.

Methods: A retrospective review of morbidity and mortality data was conducted. Read More

View Article and Full-Text PDF
December 2020

A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator.

Am J Epidemiol 2021 May 2. Epub 2021 May 2.

Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Stanford University, Stanford, California.

Evaluating gene by environment (G$\times$E) interaction under an additive risk model (i.e. additive interaction) has gained wider attention. Read More

View Article and Full-Text PDF

Changes in the respiratory function of COVID-19 survivors during follow-up: A novel respiratory disorder on the rise?

Int J Clin Pract 2021 May 1:e14301. Epub 2021 May 1.

1Department of Respiratory Medicine, G. Papanikolaou Hospital, Thessaloniki, Greece.

Background: The Human Coronavirus Disease 2019 (COVID-19) is a highly contagious respiratory disorder that may result in acute respiratory distress syndrome. The aim of this review was to investigate the incidence and type of respiratory function abnormalities during the follow-up of patients who recovered from COVID-19.

Methods: A systematic search of MEDLINE was conducted, utilising various term combinations. Read More

View Article and Full-Text PDF

Perceived stress in the time of COVID-19: the association with brooding and COVID-related rumination in adults with and without migraine.

BMC Psychol 2021 Apr 30;9(1):68. Epub 2021 Apr 30.

SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.

Background: The main goal of this research was to explore whether migraineurs had a higher level of perceived stress than healthy controls during the times of the coronavirus and related restrictive measures, and to examine the relationship between different subtypes of rumination and perceived stress in these groups. We measured two facets of depressive rumination, brooding and reflection, along with rumination about the current COVID-19 situation to see whether these different subtypes of rumination explained perceived stress among migraineurs and healthy controls.

Methods: Healthy adults (n = 64) and migraine patients (n = 73) filled out self-report questionnaires online. Read More

View Article and Full-Text PDF