4,046 results match your criteria Restrictive Lung Disease


Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: Analysis of ISHLT Registry.

J Heart Lung Transplant 2020 Jun 20. Epub 2020 Jun 20.

Division of Pulmonary, Allergy and Critical Care, Duke University Medical Center, Durham, North Carolina.

Background: Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication following lung transplant. We studied incidence and risk factors for PTLD in adult lung transplant recipients (LTRs) using the International Society for Heart and Lung Transplantation Registry.

Methods: The International Society for Heart and Lung Transplantation Registry was used to identify adult, first-time, single and bilateral LTRs with at least 1 year of follow-up between 2006 and 2016. Read More

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http://dx.doi.org/10.1016/j.healun.2020.06.010DOI Listing

Assessment of Disease Progression in Patients With Repaired Tetralogy of Fallot Using Cardiac Magnetic Resonance Imaging: A Systematic Review.

Heart Lung Circ 2020 Jul 3. Epub 2020 Jul 3.

Department of Medicine - HeartOtago, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. Electronic address:

Aims: Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart disease with a growing population of adult survivors. Late pulmonary outflow tract and pulmonary valve postoperative complications are frequent, leading to long-term risks such as right heart failure and sudden death secondary to arrhythmias. Cardiac magnetic resonance imaging (CMR) is the gold standard for assessment of cardiac function in patients with repaired ToF. Read More

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http://dx.doi.org/10.1016/j.hlc.2020.04.017DOI Listing

Cardiopulmonary Status in Adults with Osteogenesis Imperfecta: Intrinsic Lung Disease May Contribute More Than Scoliosis.

Clin Orthop Relat Res 2020 Jul 7. Epub 2020 Jul 7.

S. I. Khan, E. A. Yonko, E. M. Carter, C. L. Raggio, Hospital for Special Surgery, New York, NY, USA D. Dyer, R. A. Sandhaus, National Jewish Health, Denver, CO, USA.

Background: Osteogenesis imperfecta (OI) is a heterogeneous group of collagen-related disorders characterized by osteopenia, bone fractures, spine deformities, and nonskeletal complications. Cardiopulmonary complications are the major cause of morbidity and mortality in adults with OI. The cause of such problems was often attributed solely to the presence of large scoliosis curves affecting pulmonary function and, indirectly, cardiovascular health. Read More

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http://dx.doi.org/10.1097/CORR.0000000000001400DOI Listing

Hematologic and spirometric characteristics of Tajik and Kyrgyz highlanders in the Pamir Mountains.

Am J Hum Biol 2020 Jul 8:e23459. Epub 2020 Jul 8.

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Objectives: In this study, we measured the hematologic and spirometric parameters of native Tajik and Kyrgyz highlanders in the Pamir Mountains to investigate adaptations to high altitude stressors.

Methods: Hematological parameters including arterial oxygen saturation (SaO ), red blood cell (RBC) counts, and hemoglobin (Hb) concentration were measured on Sarikoli Tajik (n = 80; 3100 m), Wakhi Tajik (n = 48; 3500 m), and Kyrgyz (n = 64; 3250 m) in comparison to lowland Uyghurs (n = 50; 1300 m). Spirometric parameters including forced vital capacity (FVC), the first second of forced expiration (FEV1), and forced expiratory flow between 25% and 75% (FEF25-75) were measured. Read More

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http://dx.doi.org/10.1002/ajhb.23459DOI Listing

Inspiratory muscle dysfunction and restrictive lung function impairment in congenital heart disease: Association with immune inflammatory response and exercise intolerance.

Int J Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Department of Cardiology III, University Hospital Muenster, Muenster, Germany.

Background: In adult patients with congenital heart disease (ACHD), both underlying disease and lung restriction contribute to exercise intolerance. In ACHD the yet incompletely understood mechanism underlying restricted ventilation may be inspiratory muscle weakness. Therefore, this study comprehensively evaluated inspiratory muscle function in ACHD and associations with systemic inflammation and the clinical severity of exercise intolerance. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.055DOI Listing

The role of pulmonary function in patients with heart failure and preserved ejection fraction: Looking beyond chronic obstructive pulmonary disease.

PLoS One 2020 7;15(7):e0235152. Epub 2020 Jul 7.

Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: The prognostic value of chronic obstructive pulmonary disease (COPD) as a comorbidity in heart failure has been well documented. However, the role of pulmonary function indices in patients with heart failure and preserved ejection fraction (HFpEF) remains to be elucidated.

Methods: Subjects with HFpEF received pulmonary function tests and echocardiogram. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235152PLOS

Cross-sectional and longitudinal associations between urinary zinc and lung function among urban adults in China.

Thorax 2020 Jul 6. Epub 2020 Jul 6.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Background: Exposure to zinc was suggested to be associated with pulmonary damage, but whether zinc exposure affects lung function remains unclear.

Objectives: To quantify the association between urinary zinc and lung function and explore the potential mechanisms.

Methods: Urinary zinc and lung function were measured in 3917 adults from the Wuhan-Zhuhai cohort and were repeated after 3 years of follow-up. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2019-213909DOI Listing

Urgently listed lung transplant patients have outcomes similar to those of electively listed patients.

J Thorac Cardiovasc Surg 2020 Apr 21. Epub 2020 Apr 21.

Department of Thoracic and Cardiovascular Surgery, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio; Transplant Institute, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objectives: To (1) determine outcomes after urgent listing compared with elective listing for lung transplant and (2) compare in-hospital morbidity and mortality, survival, and allograft function in these 2 groups.

Methods: From January 2006 to September 2017, 201 patients were urgently and 1423 electively listed. Among urgently listed patients, 130 subsequently underwent primary lung transplant as did 995 electively listed patients. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.02.140DOI Listing

Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome.

Sci Rep 2020 Jul 2;10(1):10949. Epub 2020 Jul 2.

Department of Surgery, 987690 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE, 68198-790, USA.

Marfan syndrome (MFS) is a heritable disorder of connective tissue, caused by mutations in the fibrillin-1 gene. Pulmonary functional abnormalities, such as emphysema and restrictive lung diseases, are frequently observed in patients with MFS. However, the pathogenesis and molecular mechanism of pulmonary involvement in MFS patients are underexplored. Read More

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http://dx.doi.org/10.1038/s41598-020-67941-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331498PMC

Impact of Levodopa in Lung Functions in Patients with Parkinson Disease.

Ann Indian Acad Neurol 2020 May-Jun;23(3):338-341. Epub 2020 Jun 10.

Department of Medicine, Army College of Medical Sciences, Delhi Cantt, New Delhi, India.

Background: Parkinson's disease (PD) is the second-most common neurodegenerative disorder known primarily by its motor symptomatology. These motor manifestations are also hypothesised to affect the respiratory muscular function of PD patients contributing to restrictive pattern of ventilatory dysfunction. Previous reports attempting to detect these abnormalities through spirometric assessments have been inconclusive. Read More

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http://dx.doi.org/10.4103/aian.AIAN_88_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313576PMC

COVID-19 and restrictive lung disease: A deadly combo to trip off the fine balance.

Monaldi Arch Chest Dis 2020 Jun 29;90(2). Epub 2020 Jun 29.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA.

Coronavirus Disease (COVID-19) pandemic has so far led to innumerable deaths worldwide. The risk factors so far that have been most studied as poor prognostic factors are old age, individuals with multiple comorbidities and immunocompromised patients. Amongst the chronic lung diseases, most patients with COVID-19 reported so far had asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1346DOI Listing

Fatal course of clofazimine-induced pulmonary crystal deposition in a patient with Melkersson-Rosenthal syndrome
.

Int J Clin Pharmacol Ther 2020 Jun 26. Epub 2020 Jun 26.

A wide variety of drugs and substances have the potential to damage the respiratory system by different mechanisms. Clofazimine is an anti-leprosy drug that is normally only prescribed for a few years. It has a very long half-life, and crystalline deposition of the drug in various tissues has been documented. Read More

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http://dx.doi.org/10.5414/CP203784DOI Listing

Impact of COVID-19 pandemic on people living with visual disability.

Authors:
Suraj S Senjam

Indian J Ophthalmol 2020 Jul;68(7):1367-1370

Community Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

People living with visual disabilities/impairment are more likely vulnerable to get contracted from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV 2) than people without visual impairment. This means more than 253 million people globally will be at higher risk of affecting by the COVID-19. The current pandemic, followed by a nationwide emergency lockdown to slow the unprecedented spread of the virus, will have a serious impact on people living with visual disabilities and even endangers their lives in the long run. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1513_20DOI Listing

Shrinking Lung Syndrome: A Rare Manifestation of Systemic Lupus Erythematosus.

Cureus 2020 May 21;12(5):e8216. Epub 2020 May 21.

Internal Medicine, Corpus Christi Medical Center, Corpus Christi, USA.

Shrinking lung syndrome (SLS) is a pulmonary complication of systemic lupus erythematosus (SLE) characterized by dyspnea, pleuritic chest pain, and progressive decrease in lung volumes with no evidence of pleural or interstitial disease on chest CT. We present a 51-year-old female with a 14-year history of SLE with symptoms of progressive shortness of breath, pleuritic chest pains, low grade fevers, and productive cough which was unresponsive to multiple courses of antibiotics. After careful review of her course of SLE and timeline of symptoms, she was diagnosed with SLS. Read More

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http://dx.doi.org/10.7759/cureus.8216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306665PMC

Desquamative interstitial pneumonia: a systematic review of its features and outcomes.

Eur Respir Rev 2020 Jun 23;29(156). Epub 2020 Jun 23.

Dept of Respiratory Diseases and Allergy, Center for Rare Lung Diseases, Aarhus University Hospital, Aarhus, Denmark.

Background: Desquamative Interstitial Pneumonia (DIP) is a rare form of idiopathic interstitial pneumonia (IIP). Data on clinical features, aetiology, prognosis and effect of treatment strategies are limited. We aimed to collect all published cases to better characterise DIP. Read More

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http://dx.doi.org/10.1183/16000617.0181-2019DOI Listing

New Era of Management Concept on Pulmonary Fibrosis with Revisiting Framework of Interstitial Lung Diseases.

Tuberc Respir Dis (Seoul) 2020 Jul 29;83(3):195-200. Epub 2020 Apr 29.

Respiratory Medicine, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.

The disease concept of interstitial lung disease with idiopathic pulmonary fibrosis at its core has been relied on for many years depending on morphological classification. The separation of non-specific interstitial pneumonia with a relatively good prognosis from usual interstitial pneumonia is also based on the perception that morphology enables predict the prognosis. Beginning with dust-exposed lungs, initially, interstitial pneumonia is classified by anatomical pathology. Read More

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http://dx.doi.org/10.4046/trd.2020.0005DOI Listing

[Clinical characteristics of patients with antisynthetase syndrome and interstitial pulmonary disease].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1861-1865

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital/Institute of Respiratory Medicine, Chinese Academy of Medical Sciences/National Clinical Research Center for Respiratory Diseases, Beijing 100029, China.

To provide reference for clinicians in diagnosis and treatment of antisynthetase syndrome with interstitial pulmonary disease (ASS-ILD) by analyzing the clinical features, imaging features and pulmonary function changes of ASS-ILD patients. A total of 92 patients with ASS-ILD diagnosed in the Respiratory Center of China-Japan Friendship Hospital from January 2015 to May 2018 were included, clinical manifestations, high-resolution computed tomography (HRCT), pulmonary function test, treatment and outcome were retrospectively analyzed. The average age of the 92 patients was (58. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191120-02521DOI Listing

Effectiveness of Lung Transplantation in Patients With Interstitial Lung Diseases.

Transplant Proc 2020 Jun 19. Epub 2020 Jun 19.

Department of Cardiac, Vascular, and Endovascular Surgery and Transplantology, Silesian Center for Heart Diseases in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. Electronic address:

Background: Interstitial lung diseases (ILDs) are a heterogeneous group of more than 200 diseases manifested by progressive exercise dyspnea, radiological lung changes, and ventilation restrictive disorders. ILDs are the second most common indication for lung transplantation (LTx). Our study group consisted of 139 patients who qualified for LTx at the Silesian Center for Heart Diseases between 2004 and 2018. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.03.050DOI Listing

[Autopneumonectomie. A Forgotten Disease].

Pneumologie 2020 Jun 17;74(6):371-373. Epub 2020 Jun 17.

Abteilung für Kardiologie, Rhythmologie und konservative Intensivmedizin, Augusta-Krankenhaus Düsseldorf, Akademisches Lehrkrankenhaus der Heinrich-Heine-Universität Düsseldorf.

History:  An 80-year old female was referred to our hospital with left internal carotid artery stenosis and a childhood history of hemoptysis.

Investigations And Diagnosis:  The ECG showed 2nd degree Mobitz atrio-ventricular block. The chest x-ray and computerized tomography identified a shift of the mediastinum and the heart to the left. Read More

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http://dx.doi.org/10.1055/a-1148-8770DOI Listing

Public Attitudes, Behaviors, and Beliefs Related to COVID-19, Stay-at-Home Orders, Nonessential Business Closures, and Public Health Guidance - United States, New York City, and Los Angeles, May 5-12, 2020.

MMWR Morb Mortal Wkly Rep 2020 Jun 19;69(24):751-758. Epub 2020 Jun 19.

SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is thought to be transmitted mainly by person-to-person contact (1). Implementation of nationwide public health orders to limit person-to-person interaction and of guidance on personal protective practices can slow transmission (2,3). Such strategies can include stay-at-home orders, business closures, prohibitions against mass gatherings, use of cloth face coverings, and maintenance of a physical distance between persons (2,3). Read More

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http://dx.doi.org/10.15585/mmwr.mm6924e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302477PMC

Mixed airway and pulmonary parenchymal disease in patients with primary Sjögren's Syndrome - a six-year follow-up.

J Rheumatol 2020 Jun 15. Epub 2020 Jun 15.

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Rheumatology, Linköping University Hospital, Linköping, Sweden; Department of Translational Medicine, Lund University, Malmö, Sweden; Department of Respiratory Medicine in Linköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.; Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Jansen Cilag, Solna, Sweden; Novartis, Kista, Sweden. The study was supported by grants from ALF-Skåne, the Internal Research Funds of Skåne University Hospital, the Swedish Rheumatism Association and the Swedish Heart and Lung Foundation. Address correspondence to Anna Matilda Nilsson, E-mail:

Objective: To assess pulmonary function and Chronic Obstructive Pulmonary Disease (COPD) development over time in patients with primary Sjögren's Syndrome (pSS) and the association between pulmonary function, radiographic findings, respiratory symptoms and clinical features of pSS, taking cigarette consumption into account.

Methods: Forty patients with pSS (mean age 66 yrs, range 42-81 yrs, 39 women), previously participating in a cross-sectional study on pulmonary involvement in pSS, were re-assessed by pulmonary function tests after a mean follow-up time of six years. At follow-up, patients were also assessed by high-resolution computed tomography (HRCT) of the chest and for pSS disease activity, respiratory symptoms and cigarette consumption. Read More

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http://dx.doi.org/10.3899/jrheum.200247DOI Listing

A scenario to safely ease the covid-19 lockdown while allowing economic recovery.

Virologie (Montrouge) 2020 04;24(2):23-25

Emeritus Professor of Medicine, Aix-Marseille Université/APHM Genomic & Structural Information Laboratory (UMR 7256) Mediterranean Institute of Microbiology (FR 3479), Marseille, France Member of the board of directors of the French society of virology until March 30, 2020.

If they work as expected, the strict containment measures enforced to stop the French Covid-19 epidemic will leave a large proportion of the population "naive" about the SARS-CoV-2 virus. In these conditions, how can we prevent the epidemic from rebounding, at a time when this restrictive policy will soon become untenable economically and socially? Based on the figures, now well known, of the lethality of covid-19 according to age classes, I suggest that a gradual release of the containment be instituted, which will keep retirees in isolation (the 65+ age class), whose risk is maximal and the impact on economic production the lowest. This scenario might be applicable to most European countries that enforce mandatory retirement ages for most of workers. Read More

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http://dx.doi.org/10.1684/vir.2020.0842DOI Listing

Mixed ventilatory defects in pulmonary sarcoidosis: prevalence and clinical features.

Chest 2020 Jun 11. Epub 2020 Jun 11.

Interstitial Lung Disease Unit, Royal Brompton Hospital, London UK. Electronic address:

Background: In cohort studies of pulmonary sarcoidosis, abnormal ventilatory patterns have generally been sub-divided into restrictive and obstructive defects. Mixed ventilatory defects have been largely overlooked in pulmonary sarcoidosis as total lung capacity (TLC) has seldom been taken into account in historical series.

Research Question: We evaluated the prevalence of mixed disease in pulmonary sarcoidosis and its clinical associations. Read More

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http://dx.doi.org/10.1016/j.chest.2020.04.074DOI Listing

COVID-19 Pandemic in the Italian Population: Validation of a Post-Traumatic Stress Disorder Questionnaire and Prevalence of PTSD Symptomatology.

Int J Environ Res Public Health 2020 06 10;17(11). Epub 2020 Jun 10.

Department of Dynamic and Clinical Psychology, Sapienza University of Rome, Via degli Apuli 1, 00185 Rome, Italy.

Since December 2019, the COVID-19 pandemic has attracted worldwide attention for its rapid and exponential diffusion. The long-term psychological impact, of both the spread of the virus and the restrictive policies adopted to counteract it, remains uncertain. However, recent studies reported a high level of psychological distress and Post-Traumatic Stress Disorder (PTSD) symptoms. Read More

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http://dx.doi.org/10.3390/ijerph17114151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312976PMC

Impact of a supervised training course on spirometry competency for primary care pediatricians.

J Asthma 2020 Jun 26:1-6. Epub 2020 Jun 26.

IInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy, Palermo, Italy.

Spirometry is the most commonly performed lung function test, and performance, adherence to acceptability and repeatability criteria, and accurate interpretation of results help optimize the test's usefulness. This study aimed to measure the effects of spirometry training courses supported by the Italian Pediatric Respiratory Society (IPRS) on primary care pediatricians' (PCP) knowledge of spirometry test quality, ability to interpret results, and overall degree of satisfaction with the course. Of the six face-to-face courses, four lasted two days and two lasted one day: mean duration of theoretical lessons was five and four hours respectively; and practical sessions lasted eight and six hours, respectively. Read More

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http://dx.doi.org/10.1080/02770903.2020.1781888DOI Listing

Low serum DHEA-S is associated with impaired lung function in women.

EClinicalMedicine 2020 Jun 6;23:100389. Epub 2020 Jun 6.

Inserm UMR-S 1168, VIMA, Villejuif, France.

Background: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS).

Methods: Lung function and serum DHEA-S concentrations were measured in  = 2,045 and  = 1,725 women in 1999-2002 and in 2010-2013, respectively. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280766PMC

Impact of Respiratory Developmental Stage on Sensitivity to Late Effects of Radiation in Pediatric Cancer Survivors.

Adv Radiat Oncol 2020 May-Jun;5(3):426-433. Epub 2019 Dec 11.

Departments of Radiation Oncology and Pediatrics, University of Rochester Medical Center, Rochester, New York.

Purpose: Pulmonary dysfunction is a prevalent and potentially debilitating late effect of pediatric cancer treatment. We postulated that age, as a surrogate for respiratory developmental status, might be associated with vulnerability to pulmonary injury.

Materials And Methods: Sixty-one children treated with lung radiation at our institution who had undergone a pulmonary function test (PFT) between 1995 and 2016 were analyzed. Read More

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http://dx.doi.org/10.1016/j.adro.2019.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276690PMC
December 2019

COVID-19 and the re-opening of schools: a policy maker's dilemma.

Ital J Pediatr 2020 Jun 9;46(1):79. Epub 2020 Jun 9.

Department of Pediatric Emergency Unit, S. Orsola Hospital, Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, 40138, Bologna, Italy.

The epidemic of coronavirus disease 2019 (COVID-19) broke out in Wuhan, China, in December 2019 and rapidly spread across the world. In order to counter this epidemic, several countries put in place different restrictive measures, such as the school's closure and a total lockdown. However, as the knowledge on the disease progresses, clinical evidence showed that children mainly have asymptomatic or mild disease and it has been suggested that they are also less likely to spread the virus. Read More

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http://dx.doi.org/10.1186/s13052-020-00844-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280677PMC

Spirometric Abnormalities and Lung Function Decline in Current and Former Microwave Popcorn and Current Flavoring Manufacturing Workers.

J Occup Environ Med 2020 Jun;62(6):412-419

National Institute for Occupational Safety and Health, Respiratory Health Division, Morgantown, West Virginia (Dr Cox-Ganser, Dr White, Fedan, Bailey, Fechter-Leggett, Dr Cummings), Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah (Dr White), and Occupational Health Branch, California Department of Public Health, Richmond, California (Dr Cummings).

Objective: The aim of this study was to compare spirometry results in microwave popcorn and flavoring manufacturing workers.

Methods: We used NIOSH data on current and former microwave popcorn workers (MPWs) and surveillance data on flavoring manufacturing workers (FMWs).

Results: Former MPW had higher prevalence of mixed and high severity abnormalities, some had excessive lung function drops. Read More

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http://dx.doi.org/10.1097/JOM.0000000000001860DOI Listing

Quantifying the impact of particle matter on mortality and hospitalizations in four Brazilian metropolitan areas.

J Environ Manage 2020 May 31;270:110840. Epub 2020 May 31.

Department of Sanitary and Environmental Engineering, Federal University of Minas Gerais, Belo Horizonte, 31270-010, Brazil; Post Graduation Program on Environmental Engineering, Federal University of Espírito Santo, Vitória, Brazil. Electronic address:

Air quality management involves investigating areas where pollutant concentrations are above guideline or standard values to minimize its effect on human health. Particulate matter (PM) is one of the most studied pollutants, and its relationship with health has been widely outlined. To guide the construction and improvement of air quality policies, the impact of PM on the four Brazilian southeast metropolitan areas was investigated. Read More

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http://dx.doi.org/10.1016/j.jenvman.2020.110840DOI Listing

Noninvasive methods for detection of chronic lung allograft dysfunction in lung transplantation.

Transplant Rev (Orlando) 2020 Jul 8;34(3):100547. Epub 2020 May 8.

Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Lung transplantation (LTx) is the only therapeutic option for end-stage lung diseases. Chronic lung allograft dysfunction (CLAD), which manifests as airflow restriction and/or obstruction, is the primary factor limiting the long-term survival of patients after surgery. According to histopathological and radiographic findings, CLAD comprises two phenotypes, bronchiolitis obliterans syndrome and restrictive allograft syndrome. Read More

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http://dx.doi.org/10.1016/j.trre.2020.100547DOI Listing

Resuming elective surgery in the time of COVID-19: a safe and comprehensive strategy.

Updates Surg 2020 Jun 3;72(2):291-295. Epub 2020 Jun 3.

Department of Surgical, Medical, Pathology, and Critical Care, the University of Pisa, 56124, Pisa, Italy.

The 2019 novel corona virus and the disease it causes (COVID-19) is a public health crisis that has profoundly modified the way medical and surgical care is delivered. Countries around the globe had a variable initial response to the COVID-19 pandemic from imposing massive lock downs and quarantine to surrendering to herd immunity. However, healthcare bodies worldwide recognized early on that a triumph against COVID-19 could only be achieved by maintaining the infrastructure of healthcare systems and their capacity to accommodate a potentially overwhelming increase in critical patient care needs. Read More

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http://dx.doi.org/10.1007/s13304-020-00822-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267759PMC

Lung function evaluation in heart failure: possible pitfalls.

Breathe (Sheff) 2020 Mar;16(1):190316

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

http://bit.ly/3aEy8ed. Read More

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http://dx.doi.org/10.1183/20734735.0316-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249789PMC

Transition from Restrictive to Obstructive Lung Function Impairment During Treatment and Follow-Up of Active Tuberculosis.

Int J Chron Obstruct Pulmon Dis 2020 11;15:1039-1047. Epub 2020 May 11.

University of Cape Town Lung Institute, and Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Background: Pulmonary tuberculosis (PTB) is associated with many forms of chronic lung disease including the development of chronic airflow obstruction (AFO). However, the nature, evolution and mechanisms responsible for the AFO after PTB are poorly understood. The aim of this study was to examine the progression of changes in lung physiology in patients treated for PTB. Read More

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http://dx.doi.org/10.2147/COPD.S219731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227812PMC

The ventilatory abnormalities and prognostic values of H FPEF score in dyspnoeic patients with preserved left ventricle systolic function.

ESC Heart Fail 2020 Jun 3. Epub 2020 Jun 3.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Aims: Heart failure with preserved ejection fraction (HFpEF) is one of the major diagnoses in dyspnoeic subjects, and H FPEF score enables robust differentiation of HFpEF. Given ventilatory abnormalities prevail in subjects with HFpEF, the associations between H FPEF score and pulmonary function remain to be elucidated.

Methods And Results: Subjects who presented with exertional dyspnoea and had left ventricular ejection fraction of >50% were eligible for this study. Read More

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http://dx.doi.org/10.1002/ehf2.12754DOI Listing

Emergency Flexibility for States to Increase and Maintain Medicaid Eligibility for LTSS under COVID-19.

J Aging Soc Policy 2020 Jul-Oct;32(4-5):343-349. Epub 2020 May 31.

Research Fellow, State Health Access Data Assistance Center (SHADAC), School of Public Health, Division of Health Policy and Management, University of Minnesota , Minneapolis, Minnesota, USA.

Medicaid provides essential coverage for health care and long-term services and supports (LTSS) to low-income older adults and disabled individuals but eligibility is complicated and restrictive. In light of the current public health emergency, states have been given new authority to streamline and increase the flexibility of Medicaid LTSS eligibility, helping them enroll eligible individuals and ensure that current beneficiaries are not inadvertently disenrolled. Though state budgets are under increased pressure during the economic crisis created by the coronavirus, we caution states against cutting Medicaid LTSS eligibility or services to balance their budgets. Read More

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http://dx.doi.org/10.1080/08959420.2020.1774312DOI Listing

Association of serum ferritin and lung function in tobacco-naïve postmenopausal women: Analysis of population-based nationally representative data.

Clin Respir J 2020 May 27. Epub 2020 May 27.

Department of Family Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, South Korea.

Introduction: Ferritin regulates iron homeostasis, and is involved in the inflammation in the lung, especially in smokers; however, its associations on pulmonary function in nonsmokers remain unclear.

Objectives: The present study aimed to evaluate the association between serum ferritin and lung function in a tobacco-naïve postmenopausal women.

Methods: In this study, 25 534 individuals were enrolled, among who 5338 tobacco-naïve individuals were identified; of those, 342 men and 2879 women (742 pre- and 2137 postmenopausal) with data of serum ferritin, lung function and covariates were included. Read More

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http://dx.doi.org/10.1111/crj.13222DOI Listing

Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19: The Tri-POCUS Approach.

Cardiorenal Med 2020 27;10(4):209-216. Epub 2020 May 27.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida, USA.

As the coronavirus disease 2019 (COVID-19) continues to spread across the globe, the knowledge of its epidemiology, clinical features, and management is rapidly evolving. Nevertheless, the data on optimal fluid management strategies for those who develop critical illness remain sparse. Adding to the challenge, the fluid volume status of these patients has been found to be dynamic. Read More

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http://dx.doi.org/10.1159/000508544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316643PMC

BAG3 Myopathy Presenting With Prominent Neuropathic Phenotype and No Cardiac or Respiratory Involvement: A Case Report and Literature Review.

J Clin Neuromuscul Dis 2020 Jun;21(4):230-239

Division of Neurology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR.

Bcl-2-associated athanogene 3 (BAG3) myopathy is a rare myofibrillar myopathy characterized by toe walking and clumsiness in the first decade with rapid progression to cardiomyopathy and restrictive lung disease in the second decade. Most patients (18 patients) have the c.626C >T (p. Read More

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http://dx.doi.org/10.1097/CND.0000000000000300DOI Listing

Pulmonary Function in Patients with Multiple Endocrine Neoplasia 2B (MEN2B).

J Clin Endocrinol Metab 2020 May 25. Epub 2020 May 25.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Context: Multiple endocrine neoplasia type 2B (MEN2B) is a rare cancer predisposition syndrome resulting from an autosomal-dominant germline mutation of the RET proto-oncogene. No prior studies have investigated pulmonary function in patients with MEN2B.

Objective: This study characterized the pulmonary function of patients with MEN2B. Read More

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http://dx.doi.org/10.1210/clinem/dgaa296DOI Listing

Lung disease in patients with common variable immunodeficiency.

Allergol Immunopathol (Madr) 2020 May 20. Epub 2020 May 20.

Unidad de Inmunología e Histocompatibilidad, Hospital Dr. Carlos G. Durand, Buenos Aires, Argentina.

Background: Common Variable Immunodeficiency (CVID) is characterized by an impaired antibody production and a higher susceptibility to encapsulated bacterial infections. Lung disease is considered to be the most important cause of morbidity and mortality.

Methods: We analyzed clinical, radiological and functional characteristics in 80 patients with CVID assisted in the Unidad Inmunologia e Histocompatibilidad at Durand Hospital from 1982 to 2018. Read More

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http://dx.doi.org/10.1016/j.aller.2020.04.001DOI Listing

Comprehensive cardiopulmonary assessment in α mannosidosis.

Pediatr Pulmonol 2020 May 23. Epub 2020 May 23.

Pediatric Pulmonary Institute, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Introduction: α Mannosidosis is an extremely rare, progressive, and complex lysosomal storage disease, characterized by mental retardation, hearing impairment, coarse facial features, skeletal abnormalities, and pulmonary involvement. While bone marrow transplantation has been the only therapeutic option to date, nowadays new treatment options are being explored, which may affect pulmonary and exercise capacity.

Aim And Methods: To assess cardiopulmonary involvement in patients with α mannosidosis by pulmonary function tests, cardiopulmonary exercise testing, and low irradiation chest computed tomography (CT). Read More

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http://dx.doi.org/10.1002/ppul.24864DOI Listing

Diagnostic approach of fibrosing interstitial lung diseases of unknown origin.

Presse Med 2020 May 11;49(2):104021. Epub 2020 May 11.

Pulmonology Department, Hospital Universitario de la Princesa, Madrid, Spain; Universidad Autonoma de Madrid, Madrid, Spain.

Interstitial lung diseases encompass a broad range of numerous individual conditions, some of them characterized histologically by fibrosis, especially idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, chronic hypersensitivity pneumonia, interstitial lung disease associated with connective tissue diseases, and unclassifiable interstitial lung disease. The diagnostic approach relies mainly on the clinical evaluation, especially assessment of the patient's demographics, history, smoking habits, occupational or domestic exposures, use of drugs, and on interpretation of high-quality HRCT of the chest. Imaging is key to the initial diagnostic approach, and often can confirm a definite diagnosis, particularly a diagnosis of idiopathic pulmonary fibrosis when showing a pattern of usual interstitial pneumonia in the appropriate context. Read More

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http://dx.doi.org/10.1016/j.lpm.2020.104021DOI Listing

SARS-CoV-2/COVID-19: Evidence-Based Recommendations on Diagnosis and Therapy.

Geburtshilfe Frauenheilkd 2020 May 18;80(5):491-498. Epub 2020 May 18.

Asklepios Klinik Weißenfels, Weißenfels, Germany.

COVID-19, a new viral disease affecting primarily the respiratory system and the lung, has caused a pandemic posing serious challenges to healthcare systems around the world. In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. Mortality is about 1 - 2%. Read More

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http://dx.doi.org/10.1055/a-1156-3991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234827PMC

[Surgical Treatment of Lung Cancer Combined with Interstitial Lung Disease].

Zhongguo Fei Ai Za Zhi 2020 May;23(5):343-350

Department of Thoracic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Background: Interstitial lung disease (ILD) is a group of diffuse lung diseases that mainly involve the interstitial and alveolar cavities and result in loss of alveolar-capillary functional units, leading to restrictive ventilatory dysfunction and diffusion impairment. There was an increased incidence of lung cancer on the basis of ILD, and perioperative risk of patients with lung cancer combined with ILD (LC-ILD) was significantly increased. The aim of this study is to summarize the safety and experience of surgical treatment of LC-ILD. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2020.104.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260382PMC

Understanding Knowledge and Behaviors Related to CoViD-19 Epidemic in Italian Undergraduate Students: The EPICO Study.

Int J Environ Res Public Health 2020 05 16;17(10). Epub 2020 May 16.

Department of Medical Surgical Sciences and Translational Medicine, "Sapienza" University of Rome, Via di Grottarossa 1035/1039, 00189 Rome, Italy.

On February 2020, the novel coronavirus (2019-nCoV) epidemic began in Italy. In order to contain the spread of the virus, the Italian government adopted emergency measures nationwide, including closure of schools and universities, workplaces and subsequently lockdown. This survey was carried out among Italian undergraduates to explore their level of knowledge about the epidemic and the behaviors they adopted during the lockdown. Read More

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http://dx.doi.org/10.3390/ijerph17103481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277609PMC

Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia.

Int J Environ Res Public Health 2020 05 15;17(10). Epub 2020 May 15.

Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance-Unit of Dentistry and Oral-Maxillo-Facial Surgery, University of Modena and Reggio Emilia, 41125 Modena, Italy.

The outbreak and diffusion of the Severe Acute Respiratory Syndrome-Coronavirus-2 (Sars-CoV-2) and COronaVIrus Disease 19 (COVID-19) have caused an emergency status in the health system, including in the dentistry environment. Italy registered the third highest number of COVID-19 cases in the world and the second highest in Europe. An anonymous online survey composed of 40 questions has been sent to dentists practicing in the area of Modena and Reggio Emilia, one of the areas in Italy most affected by COVID-19. Read More

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http://dx.doi.org/10.3390/ijerph17103459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277877PMC

Fast Mass-Production of Medical Safety Shields under COVID-19 Quarantine: Optimizing the Use of University Fabrication Facilities and Volunteer Labor.

Int J Environ Res Public Health 2020 05 14;17(10). Epub 2020 May 14.

HSM lab, Center for Energy Science and Technology, Skolkovo Institute of Science and Technology, Moscow 121205, Russia.

COVID-19 pandemic provoked a number of restrictive measures, such as the closure or severe restriction of border transit for international trading traffic, quarantines and self-isolation. This caused a series of interrelated consequences that not only prevent or slow down the spread of disease, but also impact the medical systems' capability to treat the patients and help their recovery. In particular, steeply growing demand for medical safety goods cannot be satisfied by regular suppliers due to the shortage of raw materials originating from other countries or remotely located national sources, under conditions of quarantined manpower. Read More

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http://dx.doi.org/10.3390/ijerph17103418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277794PMC