3,745 results match your criteria Restrictive Lung Disease


Lung disease in STAT3-Hyper-IgE-Syndrome requires intense therapy.

Allergy 2019 Feb 21. Epub 2019 Feb 21.

Environmental Medicine, UNIKA-T, Technical University of Munich and HelmholtzZentrum Munich, Munich/Augsburg, Germany.

Background: Pulmonary complications are responsible for high morbidity and mortality rates in patients with the rare immunodeficiency disorder STAT3 hyper-IgE syndrome (STAT3-HIES). The aim of this study was to expand knowledge about lung disease in STAT3-HIES.

Methods: The course of pulmonary disease, radiological and histopathological interrelations, therapeutic management, and the outcome of 14 STAT3-HIES patients were assessed. Read More

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http://dx.doi.org/10.1111/all.13753DOI Listing
February 2019

Severe Restrictive Lung Disease in One of the Oldest Documented Males With Coffin-Lowry Syndrome.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709618820660

2 Rio Bravo Family Medicine Residency Program, Bakersfield, CA, USA.

Coffin-Lowry syndrome is expressed as different phenotypes in males and females. In males, it is characterized by facial abnormalities, marked developmental disability, and skeletal changes. Approximately 80% of cases are associated with kyphoscoliosis, which can be quite severe, as seen in our patient, causing paraplegia and restrictive lung disease. Read More

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http://dx.doi.org/10.1177/2324709618820660DOI Listing
February 2019

Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival.

J Clin Med 2019 Feb 13;8(2). Epub 2019 Feb 13.

Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

Standard methods for detecting chronic lung allograft dysfunction (CLAD) and rejection have poor sensitivity and specificity and have conventionally required bronchoscopies and biopsies. Plasma cell-free DNA (cfDNA) has been shown to be increased in various types of allograft injury in transplant recipients and CXCL10 has been reported to be increased in the lung tissue of patients undergoing CLAD. This study used a novel cfDNA and CXCL10 assay to evaluate the noninvasive assessment of CLAD phenotype and prediction of survival from bronchoalveolar lavage (BAL) fluid. Read More

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http://dx.doi.org/10.3390/jcm8020241DOI Listing
February 2019

Pulmonary functions in Egyptian children with transfusion-dependent β-thalassemia.

Transfus Med 2019 Feb 18. Epub 2019 Feb 18.

Pediatric Department, Faculty of Medicine, Minia University, El-Minya, Egypt.

Background: In β-thalassemia, there are varying degrees of ineffective haematopoiesis, intermittent haemolysis and iron overload. Excess iron is deposited in organs such as the heart, the liver, the endocrine glands and the lungs.

Objectives: To evaluate the pulmonary functions in asymptomatic beta thalassemic children on regular transfusion therapy and their relation to iron overload. Read More

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http://dx.doi.org/10.1111/tme.12539DOI Listing
February 2019

NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis.

BMC Pulm Med 2019 Feb 13;19(1):39. Epub 2019 Feb 13.

Department of Pulmonology, Hospital de São João and Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Diffuse lung diseases (DLD) are characterized by different immunophenotypes in the bronchoalveolar lavage fluid (BALF). We aimed to evaluate the diagnostic value of BALF NK and NKT cell counts of patients with DLD and lymphocytic alveolitis.

Methods: We assessed 202 patients with DLD, who underwent BALF immunophenotyping. Read More

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http://dx.doi.org/10.1186/s12890-019-0802-1DOI Listing
February 2019
2 Reads

Back to the Box: Using Lung Volumes to Predict Susceptibility to Develop Chronic Obstructive Pulmonary Disease among Smokers.

Ann Am Thorac Soc 2018 Dec;15(Supplement_4):S286-S287

University of California San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, California.

Background: Abnormal lung volumes that represent air trapping are common in chronic obstructive pulmonary disease (COPD). However, their clinical significance in those without spirometrically defined COPD (normal forced expiratory volume in 1 s [FEV] to forced vital capacity [FVC] ratio) is unclear.

Methods: Using the Veterans Administration Informatics and Computing Infrastructure (VINCI) database, we identified 7,479 patients at risk for COPD (smokers > 40 years of age without restrictive lung disease) who had preserved spirometry (FEV/FVC and FEV ≥ lower limit of normal) and also had concomitant lung volume measurements by plethysmography across 37 Veterans Affairs Medical Centers in the United States between 1985 and 2017, and examined their subsequent health records for clinical diagnoses of COPD, respiratory exacerbations, healthcare utilization, spirometry, and mortality. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201807-475MGDOI Listing
December 2018
3 Reads

Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis.

PLoS One 2019 11;14(2):e0211678. Epub 2019 Feb 11.

Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Postoperative respiratory failure (PRF, namely mechanical ventilation >48 hours) significantly affects morbidity and mortality in liver transplantation (LTx). Previous studies analyzed only one or two categories of PRF risk factors (preoperative, intraoperative or postoperative ones). The aims of this study were to identify PRF predictors, to assess the length of stay (LoS) in ICU and the 90-day survival according to the PRF in LTx patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211678PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370207PMC
February 2019
1 Read

Impact of neurological level and spinal curvature on pulmonary function in adults with spina bifida.

J Pediatr Rehabil Med 2018 ;11(4):243-254

Human Engineering Research Laboratories, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.

Purpose: To describe pulmonary function and determine the impact of neurological level, scoliosis, and obesity on pulmonary function in people with spina bifida (SB).

Methods: Participants with SB (N= 29) (15 females; age, 30 ± 12 years) completed spirometry and body plethysmographic lung volume testing. Univariate and multivariate regression analyses were used to describe the factors associated with pulmonary function in people with SB. Read More

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http://dx.doi.org/10.3233/PRM-179451DOI Listing
January 2018
1 Read

Prospective observational study in patients with obstructive lung disease: NOVELTY design.

ERJ Open Res 2019 Feb 1;5(1). Epub 2019 Feb 1.

School of Biological Sciences, University of Manchester, Manchester, UK.

Asthma and chronic obstructive pulmonary disease (COPD) have overlapping clinical features and share pathobiological mechanisms but are often considered distinct disorders. Prospective, observational studies across asthma, COPD and asthma-COPD overlap are limited. NOVELTY is a global, prospective observational 3-year study enrolling ∼12 000 patients ≥12 years of age from primary and specialist clinical practices in 19 countries (ClinicalTrials. Read More

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http://dx.doi.org/10.1183/23120541.00036-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355976PMC
February 2019
2 Reads

Phenotypical diversity of airway morphology in chronic lung graft vs. host disease after stem cell transplantation.

Mod Pathol 2019 Feb 5. Epub 2019 Feb 5.

Lung Transplant Unit, Department of Chronic diseases, Metabolism and Aging, KU Leuven, Leuven, Belgium.

Pulmonary graft vs. host disease is a diverse and underestimated complication following allogenic hematopoietic stem cell transplantation. We aimed to compare the airway architecture with chronic lung allograft dysfunction post lung transplantation. Read More

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http://dx.doi.org/10.1038/s41379-019-0203-2DOI Listing
February 2019
1 Read

Interstitial lung abnormalities: erecting fences in the path towards advanced pulmonary fibrosis.

Thorax 2019 Feb 5. Epub 2019 Feb 5.

Interstitial lung abnormalities, when present in members of undiagnosed family members recruited on the basis of familial interstitial pneumonia, or in undiagnosed research participants, have been associated with a syndrome that includes distinct sets of imaging abnormalities, restrictive physiological and exercise impairments, and an increased prevalence of histopathological findings, and genetic predictors, that have been noted in patients with idiopathic pulmonary fibrosis. Recent longitudinal studies have demonstrated that qualitative and quantitative assessments of interstitial abnormalities are associated with accelerated lung function decline, an increased rate of clinical diagnoses of interstitial lung disease and an increased rate of mortality. In this perspective, in addition to reviewing the prior information, four major efforts that could help the field of early pulmonary fibrosis detection move forward are discussed. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212446DOI Listing
February 2019
1 Read

A SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.

JCI Insight 2019 Feb 5. Epub 2019 Feb 5.

Alveolar type 2 (AT2) cell endoplasmic reticulum (ER) stress is a prominent feature in adult and pediatric interstitial lung disease (ILD and ChILD), but in vivo models linking AT2 cell ER stress to ILD have been elusive. Based on a clinical ChILD case we identified a critical cysteine residue in the Surfactant Protein C gene (SFTPC) BRICHOS domain whose mutation induced ER stress in vitro. To model this in vivo, we generated a knock-in model expressing a cysteine-to-glycine substitution at codon 121 (C121G) in the Sftpc gene. Read More

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http://dx.doi.org/10.1172/jci.insight.126125DOI Listing
February 2019
1 Read

"Small small interventions, big big roles"- a qualitative study of patient, care-giver and health-care worker experiences of a palliative care programme in Kerala, India.

BMC Palliat Care 2019 Feb 4;18(1):16. Epub 2019 Feb 4.

Department of Community Medicine, Government T.D Medical College Alappuzha, Vandanam P.O, Alappuzha, Kerala, India.

Background: Home-based palliative care is an essential resource for many communities. We conducted a qualitative study to explore perceptions of a home-based palliative care programme in Kerala, India, from the perspective of patients, their care-givers and the doctors, nurses and volunteers running the intervention.

Methods: A descriptive qualitative study was carried out. Read More

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http://dx.doi.org/10.1186/s12904-019-0400-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362568PMC
February 2019
1 Read

Comparative study of mid-thoracic spinal versus epidural anesthesia for open nephrectomy in patients with obstructive/restrictive lung disease: A randomized controlled study.

Saudi J Anaesth 2019 Jan-Mar;13(1):52-59

Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: The aim of this randomized controlled study is to compare the safety and efficacy of thoracic spinal versus thoracic epidural anesthesia for open nephrectomy in patients with obstructive/restrictive lung disease.

Methods: Sixty patients with mild to moderate chronic obstructive/restrictive lung disease undergoing open nephrectomy were randomized into two groups, 30 patients each. The thoracic spinal group (TSA) group received ultrasound guided mid-thoracic spinal anesthesia, and the thoracic epidural group (TEA) group received thoracic epidural anesthesia. Read More

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http://dx.doi.org/10.4103/sja.SJA_415_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329241PMC
January 2019
2 Reads

A prospective 5-year study of exercise performance following Melody valve implant.

Am Heart J 2018 Dec 29;209:47-53. Epub 2018 Dec 29.

Children's Hospital of Orange County, University of California, Irvine, CA. Electronic address:

Background: The long-term benefits of Melody valve implant for right ventricular outflow tract conduit obstruction or insufficiency on exercise capacity are undefined.

Methods: As part of the Melody valve clinical trial, 136 patients with congenital heart disease underwent serial cardiopulmonary exercise testing prior to, 6 months after, and annually for up to 5 years postimplant.

Results: Mean age at Melody valve implantation was 22. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.12.014DOI Listing
December 2018
1 Read

Gender- and Age-Specific Associations Between Body Fat Composition and C-Reactive Protein with Lung Function: A Cross-Sectional Study.

Sci Rep 2019 Jan 23;9(1):384. Epub 2019 Jan 23.

Department of Family Medicine, Chang-Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Lung function deterioration is frequently observed in overweight and obese patients. In the current study, we explored the contribution of body fat (BF) composition, particularly visceral and nonvisceral adiposity, to lung function deterioration. In addition, we examined gender- and age-specific differences in the association between the joint effects of BF% and C-reactive protein (CRP) concentrations with lung function. Read More

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http://dx.doi.org/10.1038/s41598-018-36860-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344558PMC
January 2019
1 Read

Surfactant protein D as a marker for pulmonary complications in pediatric patients with sickle cell disease: Relation to lung function tests.

Pediatr Pulmonol 2019 Jan 22. Epub 2019 Jan 22.

Faculty of Medicine, Pediatrics Department, Ain Shams University, Cairo, Egypt.

Background: Surfactant protein D (SP-D) is considered a candidate biomarker for lung integrity and for disease progression.

Aim: We determined the level of SP-D in children and adolescents with SCD and assessed its possible relation to pulmonary complications and lung function.

Methods: Serum SP-D levels were assessed in 50 SCD patients compared with 30 healthy controls. Read More

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http://dx.doi.org/10.1002/ppul.24257DOI Listing
January 2019
4 Reads

Restrictive spirometry pattern is associated with low physical activity levels. A population based international study.

Respir Med 2019 Jan 15;146:116-123. Epub 2018 Dec 15.

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. Electronic address:

Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with normal spirometry.

Methods: Restrictive spirometry pattern was defined as a having post-bronchodilator FEV/FVC ≥ Lower Limit of Normal and a FVC<80% predicted in two population-based studies (ECRHS-III and SAPALDIA3). Read More

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http://dx.doi.org/10.1016/j.rmed.2018.11.017DOI Listing
January 2019
2 Reads

"Structure-Function Imaging of Lung Disease Using Ultrashort Echo Time MRI".

Acad Radiol 2019 Jan 15. Epub 2019 Jan 15.

Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin - Madison, Rm. 2488, 1111 Highland Ave., Madison, WI; Department of Radiology, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI; Department of Medicine, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI; Department of Biomedical Engineering, College of Engineering, University of Wisconsin - Madison, Madison, WI. Electronic address:

Rationale And Objectives: The purpose of this review is to acquaint the reader with recent advances in ultrashort echo time (UTE) magnetic resonance imaging (MRI) of the lung and its implications for pulmonary MRI when used in conjunction with functional MRI technique.

Materials And Methods: We provide an overview of recent technical advances of UTE and explore the advantages of combined structure-function pulmonary imaging in the context of restrictive and obstructive pulmonary diseases such as idiopathic pulmonary fibrosis (IPF) and cystic fibrosis (CF).

Results: UTE MRI clearly shows the lung parenchymal changes due to IPF and CF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10766332183056
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http://dx.doi.org/10.1016/j.acra.2018.12.007DOI Listing
January 2019
8 Reads

Montelukast in chronic lung allograft dysfunction after lung transplantation.

J Heart Lung Transplant 2018 Dec 6. Epub 2018 Dec 6.

Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism & Ageing, Division of Respiratory Diseases, KU Leuven, Leuven, Belgium.

Background: Chronic lung allograft dysfunction (CLAD) is a major cause of post‒lung transplant mortality, with limited medical treatment options. In this study we assessed the association of montelukast treatment with pulmonary function and outcome in lung transplant recipients with progressive CLAD.

Methods: We performed a retrospective study of all lung transplant recipients transplanted between July 1991 and December 2016 at our center and who were treated for at least 3 months with montelukast for progressive CLAD, despite at least 3 months of prior azithromycin therapy. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.014DOI Listing
December 2018
2 Reads

Impact of presenting patient characteristics on surgical complications and morbidity in early onset scoliosis.

J Clin Neurosci 2019 Jan 8. Epub 2019 Jan 8.

Department of Orthopaedics. NYU Medical Center-Orthopaedic Hospital, New York, NY, USA. Electronic address:

This study sought to assess comorbidity profiles unique to early-onset-scoliosis (EOS) patients by employing cluster analytics and to determine the influence of isolated comorbidity clusters on perioperative complications, morbidity and mortality using a high powered administrative database. The KID database was queried for ICD-9 codes pertaining to congenital and idiopathic scoliosis from 2003, 2006, 2009, 2012. Patients <10 y/o (EOS group) were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183134
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http://dx.doi.org/10.1016/j.jocn.2018.12.007DOI Listing
January 2019
6 Reads
1.318 Impact Factor

Characteristic clinical and ultrastructural findings in nesprinopathies.

Eur J Paediatr Neurol 2018 Dec 29. Epub 2018 Dec 29.

Department of Pediatric Neurology, Developmental Neurology and Social Pediatrics, University of Essen, Germany.

Aims: To define the neurological and neuropathological alterations caused by SYNE1 mutations.

Methods: We describe 5 patients (3 males, 2 females; age 3-24 years) from 3 families. The diagnostic work-up included three muscle biopsies and two nerve biopsies in three of the cases. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.011DOI Listing
December 2018
3 Reads

Prolonged Survival in a Patient with Idiopathic Pulmonary Fibrosis Receiving Acupuncture and DHEA-Promoting Herbs with Conventional Management: A Case Report.

Perm J 2019 ;23

National University of Natural Medicine, Portland, OR.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a lethal, chronic, degenerative disease most commonly affecting the elderly population. The pathologic finding of this restrictive lung condition is excessive deposition of fibrotic tissue in the alveolar interstitium. Conventional therapies minimally alter the course of disease, and mean survival time from diagnosis is only 2 to 4 years. Read More

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http://www.thepermanentejournal.org/issues/2019/winter/6927-
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http://dx.doi.org/10.7812/TPP/18-074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326563PMC
January 2019
7 Reads

Interstitial lung diseases in dogs and cats part I: The idiopathic interstitial pneumonias.

Authors:
Carol Reinero

Vet J 2019 Jan 20;243:48-54. Epub 2018 Nov 20.

Department of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA. Electronic address:

Interstitial lung diseases (ILDs), also called diffuse parenchymal lung diseases, are a large heterogenous group of non-infectious, non-neoplastic disorders characterized by varied patterns of inflammation and fibrosis (Travis et al., 2002). In humans, accurate classification of interstitial lung diseases (ILDs) requires multidisciplinary collaboration between clinicians, radiologists and pathologists. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10900233183017
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http://dx.doi.org/10.1016/j.tvjl.2018.11.010DOI Listing
January 2019
6 Reads

Interstitial Lung Disease in patients with Polymyalgia Rheumatica: A case series.

Respir Med Case Rep 2019 21;26:126-130. Epub 2018 Dec 21.

Regional Referral Center for Rare Lung Diseases, A. O. U. "Policlinico-Vittorio Emanuele" Dpt. of Clinical and Experimental Medicine, University of Catania, Italy.

Introduction: Severe morning stiffness with painful involvement of the girdles are often referred by patients with Interstitial Lung Disease (ILD), but the association between ILD and Polymyalgia Rheumatica (PMR) is rarely reported. The purpose of the work is to describe a series of patients classified as having PMR with ILD.

Material And Methods: We retrospectively enrolled patients with a diagnosis of PMR referred to our center during the previous year for respiratory symptoms. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307098PMC
December 2018
2 Reads

Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant: A Case Report.

Transplant Proc 2018 Dec 8;50(10):4096-4098. Epub 2018 Sep 8.

Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Lipoid pneumonia is an uncommon noninfectious inflammatory lung disease characterized by lipid deposition in the alveoli, and its etiology and treatment have not been elucidated. We report the case of a 32-year-old woman who developed lipoid pneumonia 9 months after allogeneic hematopoietic stem cell transplant for chronic myelogenous leukemia in lymphoid blast crisis. She complained of progressive cough and dyspnea shortly after discontinuation of immunosuppressive therapy given for graft-vs-host disease. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.09.004DOI Listing
December 2018
1 Read

The characteristics and clinical significance of mucin levels in bronchoalveolar lavage fluid of patients with interstitial lung disease.

J Investig Med 2018 Dec 19. Epub 2018 Dec 19.

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.

To investigate the expression and clinical significance of secretory mucins in patients with interstitial lung disease (ILD). The bronchoalveolar lavage fluid (BALF) concentrations of mucins (MUCs) from 27 patients with ILD, 6 patients with lung cancer, 8 patients with pleural effusion and 9 patients with bronchiectasis were determined by ELISA. The concentration of MUC5AC was significantly increased in patients with ILD (12. Read More

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http://dx.doi.org/10.1136/jim-2018-000785DOI Listing
December 2018
1 Read
1.503 Impact Factor

Impact of burn contractures of chest wall and their surgical release on pulmonary function.

Burns 2018 Dec 15. Epub 2018 Dec 15.

Department of Burns, Plastic and Maxillofacial Surgery, VMMC & Safdarjung Hospital, New Delhi, India.

Background: Extensive burn scars and contractures are likely to restrict the movements of the chest wall which may affect the pulmonary ventilation by restricting its expansion during inspiration. We designed this study to evaluate the effect of burn contractures of chest wall on pulmonary function and to estimate the effect of contracture release on pulmonary functions in patients with compromised PFT.

Methods: Pulmonary function tests (PFT) of 20 patients having chest wall contractures involving more than 50% of the chest circumference were studied. Read More

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http://dx.doi.org/10.1016/j.burns.2018.11.014DOI Listing
December 2018
3 Reads

Recessive PYROXD1 mutations cause adult-onset limb-girdle-type muscular dystrophy.

J Neurol 2019 Feb 4;266(2):353-360. Epub 2018 Dec 4.

Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland.

Objective: To describe adult-onset limb-girdle-type muscular dystrophy caused by biallelic variants in the PYROXD1 gene, which has been recently linked to early-onset congenital myofibrillar myopathy.

Methods: Whole exome sequencing was performed for adult-onset neuromuscular disease patients with no molecular diagnosis. Patients with PYROXD1 variants underwent clinical characterization, lower limb muscle MRI, muscle biopsy and spirometry. Read More

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http://link.springer.com/10.1007/s00415-018-9137-8
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http://dx.doi.org/10.1007/s00415-018-9137-8DOI Listing
February 2019
14 Reads
3.380 Impact Factor

Assessment of Respiratory Symptoms and Pulmonary Function Status among Workers of Flour Mills in Addis Ababa, Ethiopia: Comparative Cross-Sectional Study.

Pulm Med 2018 24;2018:9521297. Epub 2018 Oct 24.

Addis Ababa University College of Medicine and Health Sciences, Department of Physiology, Addis Ababa, Ethiopia.

Background: Flour dust in the respiratory tract affects lung function. Flour dust is a heterogeneous organic substance which can have a tendency to cause respiratory ailments. There is growing consensus on the deleterious effects of flour dust on respiratory symptoms and lung performance of flour mill workers. Read More

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http://dx.doi.org/10.1155/2018/9521297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220375PMC
January 2019
2 Reads

[Medium and long-term respiratory outcome in patients operated from congenital diaphragmatic hernia: From a series of 56 patients].

Rev Pneumol Clin 2018 Dec 22;74(6):467-482. Epub 2018 Nov 22.

Service de pédiatrie et CRCM, pôle médicochirurgical de pédiatrie, CHU de Strasbourg, hôpital de Hautepierre, Strasbourg, France.

Introduction: Recent advances in prenatal diagnosis, high frequency oscillatory ventilation and pulmonary arterial hypertension (PAH) therapies have progressively improved the survival of patients with congenital diaphragmatic hernia (CDH). However, CDH is associated with high morbidity that affects about half of surviving children. The main sequelae observed are respiratory (asthma, persistent PAH [PPAH], bronchopulmonary dysplasia, respiratory infections) and digestive (gastroesophageal reflux disease [GERD]). Read More

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http://dx.doi.org/10.1016/j.pneumo.2018.10.003DOI Listing
December 2018
1 Read

Spondylocostal Dysostosis (Jarcho-Levin Syndrome) in an Adult Patient with Consanguineous Parents, in Long-Term Follow-Up.

World Neurosurg 2019 Feb 15;122:451-452. Epub 2018 Nov 15.

Department of Neuroscience and Neurosurgery, San Bortolo Hospital, Vicenza, Italy.

A 24-year-old woman presented to neurosurgical consultation for chronic back pain. The patient was long term in wheelchair for vertebral deformity. She was the third child of first-degree consanguineous parents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183260
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http://dx.doi.org/10.1016/j.wneu.2018.11.058DOI Listing
February 2019
14 Reads

Hypersensitivity pneumonitis: A fibrosing alveolitis produced by inhalation of diverse antigens.

J Allergy Clin Immunol 2018 Nov 15. Epub 2018 Nov 15.

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address:

Hypersensitivity pneumonitis (HP) is a T1 lymphocyte-biased fibrosing alveolitis caused by antigens ranging from avian excreta, fungi, thermophilic bacteria, and protozoa to reactive chemicals found in the workplace. Mimicking a viral syndrome, acute exposures to inciting antigens cause abrupt onset of nonproductive cough, dyspnea, and chills with arthralgias or malaise usually from 4 to 8 hours later so that the temporal relationship between antigen exposure and symptoms might be unsuspected. The histology of HP reveals prominent lymphocyte infiltrates that thicken the alveolar septa with poorly formed granulomas or giant cells. Read More

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http://dx.doi.org/10.1016/j.jaci.2018.09.040DOI Listing
November 2018
2 Reads

Impaired Lung Function, Lung Disease and Risk of Incident Dementia.

Am J Respir Crit Care Med 2018 Nov 15. Epub 2018 Nov 15.

Emory University School of Public Health, 25798, Atlanta, Georgia, United States.

Rationale: Growing evidence suggests that compromised lung health may be linked to dementia and worsening cognitive ability.

Objectives: We tested the hypothesis that impaired lung function or lung disease in midlife would be associated with greater risk of incident dementia and mild cognitive impairment (MCI) later in life.

Methods: A total of 14,184 ARIC study participants who underwent spirometry and were asked about lung health (1987-1989) were followed. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201807-1220OC
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http://dx.doi.org/10.1164/rccm.201807-1220OCDOI Listing
November 2018
13 Reads

[Cardiac complications of sickle cell disease in children].

Rev Med Liege 2018 Nov;73(11):550-556

Service de Pédiatrie, CHU de Liège, Belgique.

Sickle cell disease (SCD) is a genetic disorder due to an abnormal gene coding for the chain ? of the hemoglobin. The main clinical manifestations related to the major forms of SCD (SS-, SC-, and S-thalassemia) are chronic hemolysis, susceptibility to infections and vasoconstrictive crisis causing micro-emboli and/or infarction responsible for acute or chronic organ lesions. The latest are enhanced by tissue iron overload due to repeated blood transfusions. Read More

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November 2018
17 Reads

Reduced Forced Vital Capacity among HIV-infected middle-aged individuals.

J Infect Dis 2018 Nov 12. Epub 2018 Nov 12.

Department of Global Health and Internal Medicine, Amsterdam Infection and Immunity Institute and Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

Introduction: Pulmonary function impairments are more common among people living with HIV (PWH), as are contributing risk behaviors. To understand the effects of HIV infection independent of risk behaviors, pulmonary function was evaluated in lifestyle comparable HIV-positive and -negative AGEhIV-cohort participants.

Methods: Prevalence of obstructive lung disease in 544 HIV-positive and 529 HIV-negative participants was determined using spirometry. Read More

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http://dx.doi.org/10.1093/infdis/jiy653DOI Listing
November 2018
9 Reads

Respiratory adjuncts to NIV in neuromuscular disease.

Respirology 2018 Nov 8. Epub 2018 Nov 8.

Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, VIC, Australia.

Muscle weakness is an intrinsic feature of neuromuscular diseases (NMD). When the respiratory muscles are involved, the ability to take a deep breath is compromised, leading to reduced lung volumes and a restrictive ventilatory impairment. Inspiratory, expiratory and bulbar muscle weakness can also impair cough, which may impede secretion clearance. Read More

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http://dx.doi.org/10.1111/resp.13431DOI Listing
November 2018
2 Reads

Validation of a post-transplant chronic lung allograft dysfunction classification system.

J Heart Lung Transplant 2019 Feb 4;38(2):166-173. Epub 2018 Oct 4.

Lung Transplant Unit, Department of Chronic Diseases, Metabolism & Ageing (CHROMETA), Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address:

Background: Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction (CLAD). Our study evaluated the prevalence and prognostic importance of obstructive and restrictive CLAD phenotypes, with or without an identifiable underlying cause, to validate the recently proposed classification system for CLAD.

Methods: Data for patients who underwent LTx between 2004 and 2015 with a minimal survival of 180 days post-LTx were retrospectively collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183168
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http://dx.doi.org/10.1016/j.healun.2018.09.020DOI Listing
February 2019
12 Reads

The prevalence of prolonged QTc increases by GOLD stage, and is associated with worse survival among subjects with COPD.

Heart Lung 2018 Oct 31. Epub 2018 Oct 31.

Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, 90185 Umeå, Sweden. Electronic address:

Background: The role of QTc-prolongation, in relation to the increased mortality in COPD, is unclear.

Objectives: To estimate the prevalence and prognostic impact, assessed as mortality, of QTc-prolongation in COPD, restrictive spirometric pattern (RSP), and normal lung function (NLF), respectively.

Methods: All individuals (n = 993) with COPD and age- and sex-matched non-obstructive referents were identified from well-defined population-based cohorts examined in Northern Sweden in 2002-04. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01479563183014
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http://dx.doi.org/10.1016/j.hrtlng.2018.09.015DOI Listing
October 2018
5 Reads

Ventilatory and sensory responses to incremental exercise in adults with a Fontan circulation.

Am J Physiol Heart Circ Physiol 2019 Feb 2;316(2):H335-H344. Epub 2018 Nov 2.

Pacific Adult Congenital Heart Disease Clinic, Division of Cardiology, St. Paul's Hospital, University of British Columbia , Vancouver, British Columbia , Canada.

Many adults with single-ventricle congenital heart disease who have undergone a Fontan procedure have abnormal pulmonary function resembling restrictive lung disease. Whether this contributes to ventilatory limitations and increased dyspnea has not been comprehensively studied. We recruited 17 Fontan participants and 17 healthy age- and sex-matched sedentary controls. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00322.2018
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http://dx.doi.org/10.1152/ajpheart.00322.2018DOI Listing
February 2019
8 Reads

[Pulmonary fibrosis associated with hereditary fibrosing poikiloderma caused by FAM111B mutation: A case report].

Rev Mal Respir 2018 Nov 16;35(9):968-973. Epub 2018 Oct 16.

Service de pneumologie et soins intensifs, centre de compétence maladies pulmonaires rares, hôpital Européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75270 Paris, France.

Introduction: Hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis (POIKTMP) is a recently described, extremely rare, entity belonging to the spectrum of inherited poikilodermas. It is provoked by a mutation of the FAM111B gene. Respiratory involvement has never been fully described but usually involves a restrictive respiratory pattern. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.09.002DOI Listing
November 2018
1 Read

Accuracy of Reported Tidal Volume During Neonatal Ventilation With Airway Leak: A Lung Model Study.

Pediatr Crit Care Med 2019 Jan;20(1):e37-e45

Department of Neonatal Intensive Care Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.

Objectives: To determine the accuracy of tidal volume reported by neonatal ventilators, with and without leak compensation, in invasive and noninvasive ventilation modes in the presence of airway leak; and, to determine what factors have a significant effect on the accuracy of tidal volume reported by ventilators with leak compensation in the presence of airway leak. We hypothesized that ventilators with a leak compensation function that includes estimation of tidal volume could accurately report tidal volume in the presence of airway leak, but that the accuracy of reported tidal volume may be affected by variables such as the identity of the ventilator, lung mechanics, leak size, positive end-expiratory pressure level, and body size.

Design: In vitro assessment of ventilator volume delivery was conducted for seven acute care ventilators using a passive lung simulator. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001752DOI Listing
January 2019
2 Reads

Myoclonus induced by salbutamol: A case report

Biomedica 2018 09 1;38(3):303-307. Epub 2018 Sep 1.

Centro de Información y Estudio de Medicamentos y Tóxicos, Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Salbutamol is a β2 adrenergic agonist widely prescribed in patients with obstructive and restrictive lung diseases. The main side effects associated with its use are tachycardia and tremor. Myoclonus is an involuntary, irregular, abrupt, brief and sudden muscular contraction, which can be generalized, focal or multifocal. Read More

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http://dx.doi.org/10.7705/biomedica.v38i3.3813DOI Listing
September 2018
2 Reads
0.620 Impact Factor

Management of Breathlessness in Palliative Care: Inhalers and Dyspnea-A Literature Review.

Rambam Maimonides Med J 2019 Jan 28;10(1). Epub 2019 Jan 28.

Baycrest Health Sciences, Toronto, ON, Canada.

Introduction: Dyspnea is prominently observed in palliative care (PC). Dyspnea can be multifactorial, primarily caused by obstructive or restrictive lung diseases or secondarily induced by various comorbidities. Numerous interventions exist, with route of administration and efficacy requiring further discussion. Read More

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http://dx.doi.org/10.5041/RMMJ.10357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363369PMC
January 2019
12 Reads

Pulmonary manifestations in antisynthetase syndrome.

Tunis Med 2018 Feb;96(2):101-106

Introduction: Pulmonary manifestations are frequent in patients with antisynthetase syndrome which is a particular form of inflammatory myopathies.

Aim: The aim of this study is to describe clinical features and long term outcome of interstitial lung disease in these patients.

Methods: This is a retrospective descriptive study in an internal medicine department. Read More

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February 2018
3 Reads

Pulmonary function patterns and their association with genotype and phenotype in adult cystic fibrosis patients.

Acta Clin Belg 2018 Oct 12:1-7. Epub 2018 Oct 12.

a Adult Cystic Fibrosis Center , University Hospital UZ Brussel, Vrije Universiteit Brussel , Brussels , Belgium.

Background: While cystic fibrosis (CF) lung disease is generally considered to be an obstructive disorder, other pulmonary function patterns (PFP) may occur. Furthermore, little is known about possible associations between PFP and genotype or phenotypical characteristics.

Methods: Cross-sectional study including CF patients aged 16 years or more, identifying different PFP and exploring associations between PFP and genotype or phenotypical characteristics. Read More

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http://dx.doi.org/10.1080/17843286.2018.1533716DOI Listing
October 2018
7 Reads

High-flow oxygen via tracheostomy facilitates weaning from prolonged mechanical ventilation in patients with restrictive pulmonary dysfunction: two case reports.

J Med Case Rep 2018 Oct 12;12(1):292. Epub 2018 Oct 12.

Department of Anesthesiology and Pain Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Weaning from prolonged mechanical ventilation is extremely difficult in tracheostomized patients with restrictive pulmonary dysfunction. High-flow oxygen via tracheostomy supplies heated and humidified oxygen gas at > 10 L/minute. However, little has been reported on the use of high-flow oxygen via tracheostomy during weaning from ventilators in patients with restrictive pulmonary dysfunction. Read More

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http://dx.doi.org/10.1186/s13256-018-1832-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182792PMC
October 2018
4 Reads

Persistence and Progression of Airway Obstruction in Children With Early Onset Scoliosis.

J Pediatr Orthop 2018 Oct 8. Epub 2018 Oct 8.

Santa Christus Hospital Spine Center, San Antonio, TX.

Background: Obstructive lung disease occurs in 30% of children with early onset scoliosis (EOS); changes in degree of airway obstruction over time have not been reported.

Methods: Longitudinal patterns of incidental, persistent, and progressive airway obstruction were retrospectively analyzed in a cohort of children with EOS with at least 1 forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) value <85% on serial spirometric assessments over a ≥3-year observation period. The prevalence of clinical features and the severity of coronal and sagittal spine deformities for each group at the beginning and end of the study period were compared. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001262DOI Listing
October 2018
16 Reads

Acute chest syndrome in sickle cell anaemia: higher serum levels of interleukin-8 and highly sensitive C-reactive proteins are associated with impaired lung function.

Paediatr Int Child Health 2018 11 8;38(4):244-250. Epub 2018 Oct 8.

a Department of Paediatrics and Child Health , Obafemi Awolowo University (OAU) , Ile-Ife , Nigeria.

Background: Sickle cell anaemia (SCA) is a chronic inflammatory disorder with multiple organ manifestations including acute and long-term pulmonary dysfunction.

Aims/objectives: To assess lung function of children with SCA and determine the possible role of acute chest syndrome (ACS), serum inflammatory cytokines, highly sensitive C-reactive protein (hs-CRP), leucocytes and 25-hydroxyvitamin D on the development of impaired lung function.

Subjects And Methods: Lung function of 76 children with SCA was determined by spirometer and classified into normal or impaired. Read More

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https://www.tandfonline.com/doi/full/10.1080/20469047.2018.1
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http://dx.doi.org/10.1080/20469047.2018.1519988DOI Listing
November 2018
4 Reads