4,582 results match your criteria Restless Legs Syndrome


Influence of hemodialysis on pramipexole pharmacokinetics: Lessons from two cases and literature review.

Clin Nephrol Case Stud 2019 22;7:11-16. Epub 2019 Mar 22.

Department of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain Brussels.

Background: Restless legs syndrome (RLS) is not a rare condition in patients on long-term dialysis. Pramipexole is a small molecule used in the treatment of idiopathic and uremic RLS. Although some information concerning the efficacy and safety of pramipexole in uremic patients is available, data concerning the pharmacokinetics of pramipexole in hemodialysis (HD) are lacking. Read More

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http://dx.doi.org/10.5414/CNCS109641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448051PMC

The role of exercise in improving patient-reported outcomes in individuals on dialysis: A scoping review.

Semin Dial 2019 Apr 21. Epub 2019 Apr 21.

Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Exercise improves objective measures of physical function in individuals on hemodialysis, but its effect on patient-reported outcomes (PROs) is largely unknown. We performed a scoping review to characterize the existing knowledge base on exercise and PROs in dialysis patients to make recommendations for future research. We searched Medline, Embase, Cochrane Database of Systematic Reviews; Cochrane Central Register of Controlled Trials, CINAHL, and SPORT Discus from inception to November 28, 2018 and then screened results for randomized controlled trials comparing aerobic/resistance exercise, or both, with no exercise in individuals on dialysis that reported results of any PRO. Read More

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http://dx.doi.org/10.1111/sdi.12806DOI Listing

Association between restless legs syndrome and other movement disorders.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Section of Neurology (H.A.-N., F.J.J.-J.), Hospital Universitario del Sureste, Arganda del Rey, Madrid; and University Institute of Molecular Pathology Biomarkers (E.G.-M., J.A.G.A), UNEx, ARADyAL Instituto de Salud Carlos III, Cáceres, Spain.

Objective: This review focuses on the possible association between restless legs syndrome (RLS) and movement disorders, including Parkinson disease (PD), other parkinsonian syndromes, essential tremor, choreic and dystonic syndromes, Tourette syndrome, and heredodegenerative ataxias.

Methods: Review of PubMed from 1966 to September 2018 and identification of references of interest for the topic. A meta-analysis of eligible studies on the frequency of RLS in patients with PD and controls using Meta-DiSc1. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007500DOI Listing

Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: A systematic review and meta-analysis.

Complement Ther Clin Pract 2019 May 20;35:329-341. Epub 2019 Mar 20.

Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Background And Purpose: Paeoniae Radix has been used for legs discomfort such as restless legs syndrome. The aim of this review is to evaluate efficacy and safety of Paeoniae Radix-containing herbal medicine on restless legs syndrome.

Methods: Literature search was conducted on PubMed, Scopus, CENTRAL, CiNii, KTKP, OASIS, and CNKI for randomized controlled trials that evaluated the effects of Paeoniae Radix-containing herbal medicines on restless legs syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17443881183072
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http://dx.doi.org/10.1016/j.ctcp.2019.03.015DOI Listing
May 2019
1 Read

Impact of different stages of chronic kidney disease on the severity of Willis-Ekbom disease.

J Family Med Prim Care 2019 Feb;8(2):432-436

Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India.

Introduction: Willis-Ekbom disease (WED)/restless legs syndrome (RLS) is a disorder in which the patient has neurologic features such as urge of rhythmic limb movement that may decrease or stop when the limb is moved. In this study, we had tried to compare the severity of WED in different stages of chronic kidney disease (CKD).

Materials And Methods: In this study, a total of 300 patients with CKD who were >18 years of age were included. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_418_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436266PMC
February 2019
1 Read

[A Domestic Diagnosis System for Early Restless Legs Syndrome Based on Deep Learning].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Mar;43(2):79-82

School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096.

Restless legs syndrome,as a common sleep disorder,has nowadays long been diagnosed by self-rating scale and polysomnography.In this paper,a domestic diagnosis system for early restless legs syndrome based on deep learning is proposed,which is suitable for early patients with unstable symptoms in routine diagnosis.The hardware system is installed in the bed. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.02.001DOI Listing
March 2019
2 Reads

Sleep disorders in NiemannPick disease type C, beyond cataplexy.

Sleep Med 2019 Feb 19;57:122-127. Epub 2019 Feb 19.

Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Brazil; Neurology Service, Hospital Geral de Fortaleza, Fortaleza, Ceará, Brazil; Center of Health Sciences, Universidade Estadual do Ceará, Fortaleza, Ceará, Brazil. Electronic address:

Purpose: The aim of this study was to clinically characterize sleep disorders in a cohort of Niemann-Pick type C (NPC) patients, correlating these findings with disease features and polysomnographic (PSG) results.

Methods: We evaluated eight consecutive patients with molecular confirmation of NPC followed at the Hospital Geral de Fortaleza. Patients underwent a comprehensive neurological and sleep evaluation. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.02.007DOI Listing
February 2019
2 Reads

Neurochemical features of idiopathic restless legs syndrome.

Sleep Med Rev 2019 Mar 21;45:70-87. Epub 2019 Mar 21.

University Institute of Molecular Pathology Biomarkers, UNEx, ARADyAL Instituto de Salud Carlos III, Cáceres, Spain.

The most important traditional hypotheses of the pathogenesis of idiopathic restless legs syndrome (iRLS) involve dopaminergic dysfunction and iron deficiency. However, a possible role of other neurotransmitter or neuromodulators, mainly glutamate, gamma-hydroxybutyric acid (GABA), and adenosine have been suggested in recent reports. Moreover, iron deficiency in experimental models (which causes sensorimotor symptoms resembling those of RLS) is able to induce changes in dopaminergic, glutamatergic and adenosinergic neurotransmission, thus suggesting its crucial role in the pathogenesis of this disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10870792183022
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http://dx.doi.org/10.1016/j.smrv.2019.03.006DOI Listing
March 2019
3 Reads

Restless legs syndrome in patients with multiple sclerosis: evaluation of risk factors and clinical impact.

Neurologia 2019 Apr 5. Epub 2019 Apr 5.

Departamento de Neurología, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address:

Introduction: Restless legs syndrome (RLS) is a disorder characterised by an irresistible urge to move the legs, usually accompanied by unpleasant sensations. It is more frequent in patients with multiple sclerosis (MS) than in the general population.

Objectives: To evaluate the prevalence of RLS, defined according to the 4 essential requirements included in the diagnostic criteria proposed by the International Restless Leg Syndrome Study Group, in a cohort of patients with MS; and to identify potential risk factors and the clinical impact of RLS. Read More

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http://dx.doi.org/10.1016/j.nrl.2018.12.010DOI Listing
April 2019
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Self-reported restless legs syndrome and involuntary leg movements during sleep are associated with symptoms of attention deficit hyperactivity disorder.

Sleep Med 2019 Feb 11;57:115-121. Epub 2019 Feb 11.

Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Background: Restless legs syndrome (RLS) and attention-deficit hyperactivity disorder (ADHD) are disorders with virtually unknown etiologies. Several studies suggest that these disorders are comorbid. However, previous findings may have been influenced by study participants undergoing medical treatments. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.039DOI Listing
February 2019
1 Read

Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.

Nat Commun 2019 04 5;10(1):1585. Epub 2019 Apr 5.

Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.

Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10, of which 20 reach a stricter threshold of P < 8 × 10. Read More

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http://dx.doi.org/10.1038/s41467-019-09576-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451011PMC
April 2019
2 Reads
10.742 Impact Factor

Restless leg syndrome a common undiagnosed comorbidity of clinical significance in cirrhosis.

Gastroenterol Hepatol Bed Bench 2019 ;12(1):13-16

Department of Gastroenterology, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India.

Aim: Our aim was to study the prevalence and association of restless leg syndrome (RLS) in liver cirrhosis subjects.

Background: Sleep disturbances are common in cirrhosis. RLS is a chronic sensorimotor sleep disorder with an irresistible urge to move limbs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441478PMC
January 2019
1 Read

Spinal Cord Stimulation for Restless Legs Syndrome: Case Series and Mechanistic Hypothesis.

Stereotact Funct Neurosurg 2019 Apr 4:1-6. Epub 2019 Apr 4.

Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA,

Background: Spinal cord stimulation (SCS) is a well-established therapy for chronic pain syndromes, with growing applicability to other conditions. Restless legs syndrome (RLS) is a widespread, chronic movement disorder managed primarily and incompletely by medication, and its etiology can be classified as idiopathic or secondary.

Methods: Three patients underwent SCS implantation for chronic back and/or leg pain with concomitant targeting of RLS: (1) a 34-year-old man with sporadic RLS symptoms that strongly intensified after military-related spinal fractures, (2) a 54-year-old man with RLS likely secondary to meralgia paresthetica, and (3) a 42-year-old man with low back and right lower extremity pain after a military motor vehicle accident. Read More

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https://www.karger.com/Article/FullText/494737
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http://dx.doi.org/10.1159/000494737DOI Listing
April 2019
5 Reads

The Adenosine Hypothesis of Restless Legs Syndrome.

Authors:
Sergi Ferré

J Caffeine Adenosine Res 2019 Mar 14;9(1):1-3. Epub 2019 Mar 14.

Editor in Chief of the Journal of Caffeine and Adenosine Research.

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http://dx.doi.org/10.1089/caff.2019.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444903PMC
March 2019
1 Read

Spinal Cord Stimulation in Patients With Chronic Pain and Restless Legs Syndrome: A Case Report.

A A Pract 2019 Mar 27. Epub 2019 Mar 27.

Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.

Restless legs syndrome can be a debilitating condition that affects a patient's ability to function and their quality of life. Neuromodulation may represent a potential option for nonpharmacological management of restless legs syndrome. We present 3 patients who have a chronic pain diagnosis and medically refractory restless legs syndrome that warranted neuromodulation. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001007DOI Listing
March 2019
4 Reads

Restless legs syndrome in end stage renal disease patients undergoing hemodialysis.

BMC Neurol 2019 Mar 29;19(1):47. Epub 2019 Mar 29.

Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.

Background: The prevalence of Restless legs syndrome (RLS) in End Stage Renal Disease (ESRD) patients is higher than that in the general population. However, the associations of RLS within the ESRD population are inconsistent and RLS is usually neglected in dialysis centers, although it impairs the life quality among ESRD patients. We aim to investigate the prevalence of RLS in patients with ESRD undergoing maintenance hemodialysis and evaluate the risk factors of developing RLS and the effect of RLS on quality of life among ESRD patients. Read More

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http://dx.doi.org/10.1186/s12883-019-1265-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440146PMC
March 2019
2 Reads

Restless legs syndrome effectively treated with constant-pressure predilution online hemodiafiltration.

J Artif Organs 2019 Mar 27. Epub 2019 Mar 27.

Kitasato University School of Allied Health Sciences, 1-15-1, Kitasato, Minamiku, Sagamihara, Kanagawa, Japan.

Background: We encountered a case of unstable predilution online HDF due to elevated transmembrane pressure (TMP) when performing constant-speed predilution online hemodiafiltration (HDF) as treatment for restless legs syndrome (RLS) in a dialysis patient. We report the effectiveness of incorporating a newly developed constant-pressure predilution online HDF system as a preventive measure against unstable online HDF and frequent adjustment of settings when treating dialysis patients with RLS.

Case Presentation: A 55-year-old man had suffered from RLS and been undergoing constant-speed online HDF with 45 L target predilution and an ABH-21P hemodiafilter. Read More

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http://dx.doi.org/10.1007/s10047-019-01100-yDOI Listing
March 2019
1 Read

[Therapy of iron deficiency].

Authors:
Gabriele Röhrig

MMW Fortschr Med 2019 Mar;161(Suppl 1):55-61

MVZ Medicum Köln Ost, Johann Classen Strasse 68, D-51103, Köln, Deutschland.

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http://dx.doi.org/10.1007/s15006-019-0009-7DOI Listing
March 2019
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The association between migraine and restless legs syndrome: an updated systematic review and meta-analysis.

Sleep Med 2019 Feb 2;57:21-29. Epub 2019 Feb 2.

School of Medicine, Nankai University, Tianjin, 300071, China; Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:

Objective: This study aims to gain further insight into the association between migraine and restless legs syndrome (RLS).

Methods: A literature search of PubMed, Embase, and Web of Science was performed for studies investigating the association between any migraine and RLS; a meta-analysis of eligible studies was conducted to determine a pooled effect estimate for the association.

Results: Fifteen studies were included in this meta-analysis. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.027DOI Listing
February 2019
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Extracellular Vesicles Reveal Abnormalities In Neuronal Iron Metabolism In Restless Legs Syndrome.

Sleep 2019 Mar 21. Epub 2019 Mar 21.

Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD USA.

Study ObjectivesDetermine abnormalities in levels of iron-management proteins in neuronal origin-enriched extracellular vesicles (nEVs) in Restless Legs Syndrome (RLS).

Methods: We used immunoprecipitation for neuronal marker L1CAM to isolate nEVs from the serum of 20 RLS subjects from a study including MRI determinations of iron deposition in the substantia nigra and hematologic parameters and 28 age- and sex-matched Controls.

Results: RLS compared to Control subjects showed higher levels of nEV total ferritin but similar levels of transferrin receptor and ferroportin. Read More

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http://dx.doi.org/10.1093/sleep/zsz079DOI Listing
March 2019
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Sleep disorders, nocturnal blood pressure, and cardiovascular risk: A translational perspective.

Auton Neurosci 2019 May 22;218:31-42. Epub 2019 Feb 22.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy. Electronic address:

Cardiovascular disease (CVD) represents the first cause of death globally. The nighttime is generally a period of relative protection from CVD events such as myocardial infarction, sudden cardiac death, and stroke, at least compared to the early morning period. The nighttime also generally entails lower values of arterial blood pressure (ABP) and heart rate (HR) and higher cardiac parasympathetic modulation. Read More

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http://dx.doi.org/10.1016/j.autneu.2019.02.006DOI Listing
May 2019
2 Reads

Ocular morphological changes in patients with restless legs syndrome analyzed by optical coherence tomography.

Sleep Med 2019 Jan 29;57:1-5. Epub 2019 Jan 29.

Department of Neurology, Derince Training and Research Hospital, Kocaeli, Turkey.

Background: Two leading hypotheses for restless legs syndrome (RLS) pathophysiology are dopaminergic dysfunction and sympathetic overactivity. Ocular changes occur with both dopaminergic and sympathetic pathologies, and thus may provide unique insights into the pathophysiology of RLS.

Methods: Thirty-five patients with RLS and 35 healthy individuals were enrolled in the study. Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.024DOI Listing
January 2019
2 Reads

Sleep disorders in patients with psoriasis: a cross-sectional study using non-polysomnographical methods.

Sleep Breath 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, Faculty of Medicine, Bozok University, 66200, Yozgat, Turkey.

Background: Psoriasis is a chronic inflammatory skin disease which can cause sleep disturbances due to the disease itself or due to its complications. In this study, we aimed to analyze the array of sleep disturbances caused by psoriasis and to evaluate the interaction between the quality of sleep and the duration and severity of psoriasis.

Methods: Study subjects included 60 patients with plaque psoriasis and 60 sex- and age-matched controls. Read More

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http://dx.doi.org/10.1007/s11325-019-01820-8DOI Listing
March 2019
1 Read

Movement disorders in early MS and related diseases: A prospective observational study.

Neurol Clin Pract 2019 Feb;9(1):24-31

Multiple Sclerosis and Neuroimmunology Program (HA), University Hospitals of Cleveland; Case Western Reserve University School of Medicine (HA, KK), Cleveland; and Center for Neurological Restoration (XXY, HHF) and The Mellen Center for Multiple Sclerosis Treatment and Research (JAC), Cleveland Clinic, OH.

Background: Little is known about the true prevalence and clinical characteristics of movement disorders in early multiple sclerosis (MS) and related demyelinating diseases. We conducted a prospective study to fill this knowledge gap.

Methods: A consecutive patient sample was recruited from the MS clinic within a 1-year-period. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382384PMC
February 2019
2 Reads

Prevalence and Significance of Restless Legs Syndrome in Patients With Coronary Artery Disease.

Am J Cardiol 2019 Feb 23. Epub 2019 Feb 23.

Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Restless legs syndrome (RLS), characterized by leg restlessness and dysesthesia predominantly at night and at rest, disrupts sleep and quality of life. The reported prevalence of RLS is 2% to 5%. Although a relation between RLS and coronary artery disease has been suggested, the prevalence and clinical significance of RLS in coronary artery disease patients remain unknown. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.017DOI Listing
February 2019
2 Reads

[Somatization].

Authors:
Rino Scuccato

Recenti Prog Med 2019 Feb;110(2):100-105

Neurologo libero professionista, Vicenza.

Functional disorders that we observe neurologically primarily pose terminology problems: some of them such as migraine, narcolepsy, restless legs syndrome have a recognized nosographic status, although without demonstrable lesions; others are interpreted only as somatic manifestations of psychic conflicts. There is also the risk that the "functional" diagnosis masks - as prejudice - lesional pathologies not adequately investigated with the available technology, leading to serious clinical errors. Moreover, even in presence of a probable psychogenic disorder, patients tend to reject the "functional" diagnosis, for cultural reasons linked to the old philosophical separation between diseases of the body and mind (the latter with a "lower" status). Read More

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http://dx.doi.org/10.1701/3112.31007DOI Listing
February 2019
1 Read

A sleep apnoea questionnaire predicts organ damage in hypertensive patients.

Blood Press 2019 Mar 6:1-11. Epub 2019 Mar 6.

a Clinica dell'Ipertensione Arteriosa, Department of Medicine - DIMED , University of Padua , Italy.

Background: Arterial hypertension is associated with obstructive sleep apnoea, poor quality and duration of sleep, which might contribute to hypertension-mediated organ damage.

Methods: We investigated the presence of insomnia, restless legs syndrome, and obstructive sleep apnoea using validated questionnaires (Insomnia Severity Index, Restless Legs Syndrome Rating Scale, and STOP-Bang), and their relationship with hypertension-mediated organ damage, in hypertensive patients.

Results: In 159 consecutive consenting hypertensive patients [age 47(11) years, median and (interquartile range), body mass index 25. Read More

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https://www.tandfonline.com/doi/full/10.1080/08037051.2019.1
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http://dx.doi.org/10.1080/08037051.2019.1586429DOI Listing
March 2019
4 Reads

Nocturnal Activity Is Not Affected by a Long-Duration, Low-Intensity Single Exercise Bout.

Sports (Basel) 2019 Mar 1;7(3). Epub 2019 Mar 1.

School of PE and Sport Science, University of Thessaly, 42100 Trikala, Greece.

The aim of the current study was to examine whether prolonged low-intensity aerobic exercise could affect nocturnal activity in healthy individuals. Twenty-one healthy adults (24 ± 3.7 years; 9 females) were enrolled in this study. Read More

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http://dx.doi.org/10.3390/sports7030056DOI Listing
March 2019
1 Read

Creativity related to dopaminergic treatment: A multicenter study.

Parkinsonism Relat Disord 2019 Feb 22. Epub 2019 Feb 22.

Departments of Neurology, Hospital Fundación Alcorcon, Madrid, Spain.

Impulse control disorder (ICD), including pathological gambling, hypersexuality, and compulsive shopping has been linked to dopaminergic treatment, especially treatment with dopamine agonists (DAs). However, patients with Parkinson's disease (PD) may experience enhanced creativity during DA therapy, often manifesting as newfound artistic pursuits. Though ICD is very well recognized in the literature, enhanced creativity remains underreported, probably because, unlike ICD, enhanced creativity is often positive and rarely disruptive for patients and relatives. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.010DOI Listing
February 2019
4 Reads

Biological and clinical insights from genetics of insomnia symptoms.

Nat Genet 2019 03 25;51(3):387-393. Epub 2019 Feb 25.

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Read More

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http://dx.doi.org/10.1038/s41588-019-0361-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415688PMC
March 2019
3 Reads

Sleep-related disorders and their relationship with MRI findings in multiple sclerosis.

Sleep Med 2019 Jan 21. Epub 2019 Jan 21.

IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences and Università Vita-Salute San Raffaele, Milan, Italy. Electronic address:

Sleep-related disorders have been reported to have a higher prevalence in multiple sclerosis (MS) than in the general population. They are often undervalued for the presence of more severe physical problems and the occurrence at night, without a direct observation in common clinical practice, but if not recognized and treated they can negatively affect the quality of life causing daytime drowsiness and worsening fatigue. Sleep related disorders most commonly reported in MS are as follows: insomnia, sleep-related breathing disorders (SRBD), restless legs syndrome (RLS) and periodic limb movement disorders (PLMD). Read More

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http://dx.doi.org/10.1016/j.sleep.2019.01.010DOI Listing
January 2019
15 Reads

Iron supplementation for restless legs syndrome - A systematic review and meta-analysis.

Eur J Intern Med 2019 Feb 21. Epub 2019 Feb 21.

Internal Medicine A, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel and Sackler faculty of Medicine, Tel-Aviv University, Israel.

Background: Iron supplementation, is recommended for the treatment of restless legs syndrome (RLS). We gathered evidence for the efficacy and safety of iron supplementation for RLS.

Methods: A systematic review and meta-analysis of randomized controlled trials that compared iron supplementation versus no iron for patients with RLS was performed. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.02.009DOI Listing
February 2019
2 Reads

Characterization of painful Restless Legs Syndrome sensations in an English-speaking South African population.

Scand J Pain 2019 Feb 23. Epub 2019 Feb 23.

Department of Family Medicine, Faculty of Health Sciences, University of the Witwatersrand Medical School, Parktown, Johannesburg, South Africa.

Background and aims Restless Legs Syndrome (RLS) is characterised by unusual sensations in the legs which can be described as painful in up to 60% of RLS patients. The purpose of this study was to characterise and examine whether the presence of pain influenced the words used to describe the sensations of RLS in an English speaking population. Methods RLS participants (n=55) were divided according to whether or not painful RLS sensations were reported upon questioning. Read More

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http://dx.doi.org/10.1515/sjpain-2018-0313DOI Listing
February 2019
1 Read

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study.

Brain 2019 Mar;142(3):744-759

Department of Neurology, McGill University, Montreal General Hospital, Montreal, Canada.

Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, and potentially intervene with neuroprotective therapy. For future neuroprotective trials, it is essential to accurately estimate phenoconversion rate and identify potential predictors of phenoconversion. Read More

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http://dx.doi.org/10.1093/brain/awz030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391615PMC
March 2019
3 Reads

Association between child maltreatment and central sensitivity syndromes: a systematic review protocol.

BMJ Open 2019 Feb 19;9(2):e025436. Epub 2019 Feb 19.

School of Nursing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Introduction: A growing body of evidence is identifying the link between a history of child maltreatment and a variety of adverse health outcomes ultimately leading to significant social and healthcare burden. Initial work has identified a potential association between child maltreatment and the development of a selection of somatic and visceral central sensitivity syndromes: fibromyalgia, chronic fatigue syndrome, temporomandibular joint disorder, chronic lower back pain, chronic neck pain, chronic pelvic pain, interstitial cystitis, vulvodynia, chronic prostatitis, tension-type headache, migraine, myofascial pain syndrome, irritable bowel syndrome and restless legs syndrome.

Methods And Analysis: Primary electronic searches will be performed in the Embase, MEDLINE, PubMed, Scopus, PyscINFO, CINAHL and Cochrane Library databases and a number of Grey Literature sources including child protection and paediatric conference proceedings. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02543
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-025436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368161PMC
February 2019
6 Reads

The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 04 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
April 2019
2 Reads

Reduced response to gabapentin enacarbil in restless legs syndrome following long-term dopaminergic treatment.

Sleep Med 2019 Mar 26;55:74-80. Epub 2018 Dec 26.

European Sleep Institute, Santiago, Chile. Electronic address:

Objectives: To determine whether long-term treatment with dopaminergic agents (DAs) might dampen the response to a non-dopaminergic agent, such as gabapentin enacarbil.

Methods: We performed a two-week randomized, double-blind, crossover, and placebo-controlled study in a single, referral center in dopamine treatment-naive patients and non-augmented patients continuously treated with dopaminergics for the last five consecutive years. Following washout from any previous CNS-active drugs, patients were randomized into one of two groups for two consecutive two-week treatment periods with gabapentin enacarbil (GBPen) and placebo. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.025DOI Listing
March 2019
1 Read

Acceptability and feasibility of a 12-week yoga vs. educational film program for the management of restless legs syndrome (RLS): study protocol for a randomized controlled trial.

Trials 2019 Feb 15;20(1):134. Epub 2019 Feb 15.

Department of Epidemiology, West Virginia University School of Public Health, HSC N, PO Box 9190, Morgantown, WV, 26506, USA.

Background: Restless legs syndrome (RLS) is a common and burdensome sleep disorder associated with profound impairment of health, well-being, and quality of life. Unfortunately, the medications used for RLS management carry risk of serious side effects, including augmentation of symptoms. Yoga, an ancient mind-body discipline designed to promote physical, emotional, and mental well-being, may offer a viable, low-risk new treatment. Read More

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http://dx.doi.org/10.1186/s13063-019-3217-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377785PMC
February 2019
3 Reads

Successful spinal cord stimulation for severe medication-refractory restless legs syndrome.

Mov Disord 2019 Apr 15;34(4):585-586. Epub 2019 Feb 15.

Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/mds.27644DOI Listing
April 2019
1 Read

Restless Legs Syndrome Among Veterans With Spinal Cord Lesions.

Fed Pract 2018 Apr;35(Suppl 3):S17-S20

is a Neurologist with Noran Neurological Clinic in Minneapolis, Minnesota. is an Associate Professor of Neurology and Program Director of the Sleep Medicine Fellowship at the Mayo Clinic in Jacksonville, Florida. is an Associate Professor of Psychiatry at King Edward Medical University in Lahore, Pakistan. is the Medical Director at the Center for Sleep Medicine at the VA North Texas Health Care System and Associate Professor of Psychiatry and Neurology at the University of Texas Southwestern Medical Center in Dallas.

Researchers developed a restless legs syndrome questionnaire using diagnostic criteria to assess its prevalence among veterans with spinal cord injuries and disorders. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375435PMC
April 2018
1 Read

Serum Interleukin-6 is Not Linked with Sleep-Quality, Restless Legs Syndrome, and Depression, But with 6-Month Survival in Hematological Malignancies.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):94-100

Department of Psychiatry, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

Background: Serum interleukin (IL)-6 has been found to be associated with sleep quality, mood, and survival in patients with solid tumors. Results in these studies were confounded by knowledge of diagnosis to study subjects. Moreover, such data among subjects with hematological malignancies and data regarding restless legs syndrome is limited. Read More

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http://www.ruralneuropractice.com/text.asp?2019/10/1/94/2432
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http://dx.doi.org/10.4103/jnrp.jnrp_159_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338000PMC
February 2019
3 Reads

Prevalence and Characteristics of Restless Legs Syndrome in Korean Adults: A Study in Two Independent Samples of the General Population.

Neuroepidemiology 2019 14;52(3-4):193-204. Epub 2019 Feb 14.

Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea,

Background: Restless legs syndrome (RLS) is a common sleep disorder, although it has a low prevalence in Asian populations. However, the reported RLS prevalence in -Korean adults is mostly 4.5-12. Read More

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http://dx.doi.org/10.1159/000496839DOI Listing
February 2019
1 Read

The Parkinson's disease and restless legs syndrome/Willis-Ekbom disorder link: evidences, biases and clinical relevance.

Arq Neuropsiquiatr 2019 Jan;77(1):47-54

Universidade Nove de Julho, São Paulo SP, Brasil.

Parkinson's disease (PD) and restless legs syndrome/Willis-Ekbom disorder (RLS/WED) are relatively common diseases in the realm of movement disorders. The fact that both may, as expected, co-occur and typically share a similar remarkable response to dopaminergic treatment raised the interest in exploration of additional shared features that throughout the years cruised fields as diverse as phenomenology, epidemiology, genetics, pathology, and clinical studies. In this review, we describe and critically examine the evidence and biases of a conceivable overlap of these two disorders, trying to shed light onto two main sources of confusion: (1) are PD and RLS/WED reciprocal risk factors? and (2) what are the main mimics of RLS/WED in PD? Read More

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http://dx.doi.org/10.1590/0004-282X20180125DOI Listing
January 2019
1 Read

Sleep Complaints, Sleep and Breathing Disorders in Myotonic Dystrophy Type 2.

Curr Neurol Neurosci Rep 2019 Feb 9;19(2). Epub 2019 Feb 9.

Department of Clinical Medicine and Surgery, Section of Respiratory Diseases, University of Naples Federico II, Naples, Italy.

Purpose Of Review: To update the current knowledge concerning sleep complaints and breathing disorders in myotonic dystrophy type 2 (DM2) and to better understand if sleep and breathing symptoms may add a further clinical definition of DM2.

Recent Findings: Although DM2 has been poorly evaluated, the most relevant sleep disorders are sleep-disordered breathing (SDB) (37.5-66. Read More

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http://link.springer.com/10.1007/s11910-019-0924-0
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http://dx.doi.org/10.1007/s11910-019-0924-0DOI Listing
February 2019
3 Reads

[Restless legs syndrome from the perspective of psychiatry].

Authors:
Patricia Rubí G

Rev Med Chil 2018 Sep;146(9):1041-1049

Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.

Restless Legs Syndrome (RLS) or Willis-Ekbom Disease is an under-diagnosed chronic and progressive primary sensory-motor disorder. It can lead to severe sleep disturbances, a usual cause of consultation. It is characterized by an urgent need to move the legs in resting situations, a cardinal symptom that is usually accompanied by an unpleasant sensation in legs. Read More

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http://dx.doi.org/10.4067/s0034-98872018000901041DOI Listing
September 2018
3 Reads

[Sleep Disorders in Old Age].

Praxis (Bern 1994) 2019 Jan;108(2):125-130

1 Neurologische Klinik, Kantonsspital St. Gallen.

Sleep Disorders in Old Age Abstract. Sleep disorders increase with age. Older patients rarely complain about sleep disorders, therefore it is important to ask about sleep problems. Read More

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http://dx.doi.org/10.1024/1661-8157/a003171DOI Listing
January 2019
8 Reads

[Sleep Disturbances in General Practitioners' Offices: From Screening to Initial Therapy - Update 2019].

Praxis (Bern 1994) 2019 Jan;108(2):103-109

1 Klinik für Schlafmedizin, Bad Zurzach.

Sleep Disturbances in General Practitioners' Offices: From Screening to Initial Therapy - Update 2019 Abstract. The field of sleep medicine has established internationally as an interdisciplinary specialization. Due to prevailing evidence, sleep disturbances are listed in a separate chapter in the new ICD 11 classification system. Read More

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http://dx.doi.org/10.1024/1661-8157/a003166DOI Listing
January 2019
2 Reads

Restless legs syndrome and iron deficiency in adults with attention deficit hyperactivity disorder.

Sleep 2019 Feb 5. Epub 2019 Feb 5.

National Reference Network for Narcolepsy, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, France.

Objective: The association between restless legs syndrome (RLS), periodic leg movements during sleep (PLMS) and iron deficiency has been reported in children with attention deficit/hyperactivity disorder (ADHD); however little is known in adults. The aim of this study was to assess frequencies of RLS, PLMS and other leg movements (LM) and iron deficiency and their relationships with ADHD phenotype in adults with ADHD.

Methods: 200 adults with ADHD (112 males, median age 31 years) were evaluated on lifetime ADHD symptoms and sleep characteristics. Read More

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http://dx.doi.org/10.1093/sleep/zsz027DOI Listing
February 2019
3 Reads

Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson's Disease.

Parkinsons Dis 2019 2;2019:1654161. Epub 2019 Jan 2.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson's disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS.

Objective: To delineate NMS in FDR of patients with different clinical types of PD. Read More

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http://dx.doi.org/10.1155/2019/1654161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334354PMC
January 2019
4 Reads

Therapeutic drug monitoring of gabapentin in various indications.

Acta Neurol Scand 2019 May 19;139(5):446-454. Epub 2019 Feb 19.

Department of Pharmacology, Oslo University Hospital, Oslo, Norway.

Objectives: Gabapentin has been increasingly used in various indications in recent years. Despite variable pharmacokinetics, therapeutic drug monitoring (TDM) is scarcely described in other indications than epilepsy. The aim of the study was to investigate the use and pharmacokinetic variability of gabapentin in epilepsy and non-epilepsy indications and to further evaluate the use of TDM in patients with restless legs syndrome (RLS). Read More

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http://dx.doi.org/10.1111/ane.13075DOI Listing
May 2019
2 Reads