5,943 results match your criteria Restless Legs Syndrome


Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies.

Sleep 2018 Dec 14. Epub 2018 Dec 14.

Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-Universität Münster, Münster, Germany.

Study Objectives: Periodic limb movements in sleep (PLMS) are frequent motor phenomena; however, population-based data are scarce. We assessed the prevalence of PLMS and factors associated with PLMS within two German population-based cohorts, the SHIP-TREND and BiDirect.

Methods: Single-night polysomnography was performed on 1107 subjects recruited from the general population (mean age: 52. Read More

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December 2018
1 Read

US acculturation and poor sleep among an intergenerational cohort of adult Latinos in Sacramento, California.

Sleep 2018 Dec 13. Epub 2018 Dec 13.

Department of Epidemiology; Gillings School of Global Public Health; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina.

Acculturation may shape the disproportionate burden of poor sleep among Latinos in the US. Existing studies are limited by unidimensional acculturation proxies that are incapable of capturing cultural complexities across generations. Understanding how acculturation relates to sleep may lead to the identification of modifiable intervention targets. Read More

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December 2018

Restless Legs Syndrome in Children.

Pediatr Ann 2018 Dec;47(12):e504-e506

Restless legs syndrome (RLS) is a common pediatric condition that often goes undiagnosed. The genetics and pathophysiology of this sensorimotor condition are still not well understood. RLS can affect any part of the body, but the thighs and calves are the most commonly affected. Read More

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December 2018

Is there a relationship between restless legs syndrome and medical problems in pregnant women? A cross-sectional study in Iran.

Acta Neurol Belg 2018 Dec 12. Epub 2018 Dec 12.

Midwifery Department, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This study aimed to assess the relationship between RLS and medical problems among pregnant women. In this study, 700 pregnant women were recruited. A socio-demographic questionnaire and the International Restless Legs Questionnaire were used to gather information. Read More

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December 2018
1 Read

Gabapentin enacarbil for antipsychotic induced akathisia in schizophrenia patients: a pilot open-labeled study.

Neuropsychiatr Dis Treat 2018 22;14:3179-3184. Epub 2018 Nov 22.

Akita Prefectural Mental Health and Welfare Center, Akita City, Akita 010-0001, Japan.

Objective: Gabapentin and its prodrug are candidate therapeutic agents for akathisia. An open-label pilot study was conducted to investigate the therapeutic potential of gabapentin enacarbil (GE) for akathisia.

Methods: In an open-labeled investigator-initiated clinical trial, nine outpatients with antipsychotics-induced akathisia were administered GE (300 or 600 mg/day) over 2 weeks. Read More

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November 2018

Genetic factors influencing hemoglobin levels in 15,567 blood donors: results from the Danish Blood Donor Study.

Transfusion 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Immunology, Capital Region, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Blood donors have an increased risk of low hemoglobin (Hb) levels due to iron deficiency. Therefore, knowledge of genetic variants associated with low Hb could facilitate individualized donation intervals. We have previously reported three specific single-nucleotide polymorphisms that were associated with ferritin levels in blood donors. Read More

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December 2018

Clinical feasibility of 1-min ultrafast brain MRI compared with routine brain MRI using synthetic MRI: a single center pilot study.

J Neurol 2018 Dec 7. Epub 2018 Dec 7.

MR Applications and Workflow, GE Healthcare Korea, 343 Hakdong-ro, Gangnam-gu, Seoul, 06060, Republic of Korea.

Background: Ultrafast brain MRI is required for uncooperative patients and time-critical diseases such as stroke because it reduces scan times and motion artifacts. This study investigated the clinical feasibility of a 1-min ultrafast brain MRI protocol for detecting intracranial abnormalities in restless and uncooperative patients.

Methods: We retrospectively reviewed the records of 25 patients who underwent a 1-min ultrafast MRI protocol using T1-weighted image, T2-weighted image, echo-planar fluid-attenuated inversion recovery, diffusion-weighted image, and T2*-weighted image between March 2017 and May 2017. Read More

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December 2018
1 Read
3.377 Impact Factor

(Trichocomaceae): A Natural, Eco-Friendly Mycoinsecticide for Control of Malaria, Filariasis, Dengue Vectors and Its Toxicity Assessment Against an Aquatic Model Organism .

Front Pharmacol 2018 26;9:1355. Epub 2018 Nov 26.

Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Salem, India.

Vector-borne diseases like malaria, filariasis, and dengue are transmitted by mosquitoes and they cause global mortality and morbidity due to an increased resistance against commercial insecticides. The present study was aimed to evaluate the neurobehavioral toxicity, knock-down effect, histopathology, ovicidal, adulticidal, and smoke toxicity effect of extract against three mosquito species, namely , and (Diptera: Culicidae). The isolated fungal strain was identified as (GenBank accession no: KX694148. Read More

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November 2018

Not the Function of Eating, but Spontaneous Activity and Energy Expenditure, Reflected in "Restlessness" and a "Drive for Activity" Appear to Be Dysregulated in Anorexia Nervosa: Treatment Implications.

Authors:
Regina C Casper

Front Psychol 2018 23;9:2303. Epub 2018 Nov 23.

Department of Psychiatry, Stanford University School of Medicine, Stanford, CA, United States.

Anorexia nervosa (AN) is uncommon as a syndrome, despite widespread dieting or voluntary food restriction, especially among female adolescents. This suggests that restriction of caloric intake might not be the only component driving weight loss in AN. Historical observations and experimental evidence from energy expenditure studies and recordings from movement sensors reviewed in this paper reveal that AN is associated with motor activity levels and with an energy output not significantly different from that in normal-weight healthy age-matched controls. Read More

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November 2018

Prenatal alcohol exposure and sleep-wake behaviors: exploratory and naturalistic observations in the clinical setting and in an animal model.

Sleep Med 2018 Oct 25;54:101-112. Epub 2018 Oct 25.

Department of Cellular & Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Introduction: Clinical research and studies using animal models have revealed a complex and relatively under-explored interaction between prenatal alcohol exposure (PAE) and alterations in sleep-wake behaviors.

Objectives: To utilize a structured naturalistic observation-based methodology, consisting of descriptive elements, to provide insight into possible links between altered sleep and disruptive daytime presentations in children and adolescents with fetal alcohol spectrum disorder (FASD). To apply a similar structured behavioral observation protocol in a PAE animal model to compare outcomes from the experimental and clinical studies utilizing naturalistic observational methodology. Read More

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October 2018

Validation of the self-administered version of the international Restless Legs Syndrome study group severity rating scale - The sIRLS.

Sleep Med 2018 Oct 29;54:94-100. Epub 2018 Oct 29.

The International Restless Legs Syndrome Study Group, Rochester, MN, USA.

Introduction: The International Restless Legs Study Group (IRLSSG) has developed the IRLS (International Restless Legs Syndrome Severity Scale) and validated it as a clinician/researcher administered scale to be used when both patient and examiner are present. The IRLSSG recognized the need for a self-completing scale that can be used economically in clinical practice and in large population-based studies. In this study the validity and the reliability of the IRLS as a self-administered scale (sIRLS) is assessed. Read More

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October 2018

Polygenic risk score identifies associations between sleep duration and diseases determined from an electronic medical record biobank.

Sleep 2018 Dec 5. Epub 2018 Dec 5.

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.

Study Objectives: We aimed to detect cross-sectional phenotype and polygenic risk score (PRS) associations between sleep duration and prevalent diseases using the Partners Biobank, a hospital-based cohort study linking electronic medical record (EMR) with genetic information.

Methods: Disease prevalence was determined from EMR, and sleep duration was self-reported. A PRS for sleep duration was derived using 78 previously associated SNPs from GWAS for self-reported sleep duration. Read More

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December 2018
2 Reads

Pain therapy for the elderly patient: is opioid-free an option?

Curr Opin Anaesthesiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Anesthesiology and Pain Medicine, Ludwig-Maximilians University Munich.

Purpose Of Review: Chronic noncancer pain is an increasing problem in elderly because of rising life expectancy together with an increase of potentially painful medical conditions. Concomitantly, adequate treatment of elderly is often limited by coexisting diseases and polypharmacy.This review summarizes the most important specifics presented by elderly patients and discusses the pharmacological and nonpharmacological options of pain management. Read More

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December 2018
1 Read

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.

Authors:
Sherifa A Hamed

Expert Rev Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

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December 2018
1 Read

Factors contributing to excessive daytime sleepiness in Korean adults with epilepsy: A sleep questionnaire-based study.

Epilepsy Behav 2018 Dec 1;90:61-65. Epub 2018 Dec 1.

Department of Neurology, Gil Medical Center, Gachon Medical School, Incheon, Republic of Korea.

Objectives: We determined factors contributing to excessive daytime sleepiness (EDS) in Korean adults with epilepsy (AWE).

Methods: A total of 147 AWE who had been treated for >1 year were included. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Read More

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December 2018
2 Reads

Comparison of Perioperative Systemic Lidocaine or Systemic Ketamine in Acute Pain Management of Patients With Opioid Use Disorder After Orthopedic Surgery.

J Addict Med 2018 Nov 28. Epub 2018 Nov 28.

Shiraz Anesthesiology and Intensive Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction And Aims: Patients with opioid use disorder experience great challenges during acute pain management due to opioid tolerance or withdrawal symptoms. Previous studies have recommended the use of adjuvant drugs in these patients. In this study, we compared the effect of intraoperative lidocaine with ketamine in postoperative pain management of these patients. Read More

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November 2018
1 Read

The first night effect in multiple sclerosis patients undergoing home-based polysomnography.

Nat Sci Sleep 2018 26;10:337-344. Epub 2018 Oct 26.

NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: The first night effect (FNE) is a polysomnography (PSG) habituation effect in the first of several consecutive in-laboratory PSGs (I-PSGs). The FNE is caused by the discomfort provoked by electrodes and cables and the exposure to an unfamiliar environment. A reverse FNE (RFNE) with an improved sleep in the first night is characteristic of insomnia, presumably because the video PSG in the sleep laboratory leads to a decrease in the negatively toned cognitive activity. Read More

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October 2018
1 Read

[Daytime Sleepiness in Patients with Restless Legs Syndrome: A Risk Factor for Traffic Accidents?]

Praxis (Bern 1994) 2018 Nov;107(24):1319-1323

1 Institut für Rechtsmedizin der Universität Zürich (IRM UZH).

Daytime Sleepiness in Patients with Restless Legs Syndrome: A Risk Factor for Traffic Accidents? Abstract. Restless legs syndrome (RLS) is a symptom complex of predominantly leg-focused paraesthesias and the associated increased urge to move. Since evening exacerbations are typical, many patients suffer from sleep disorders, which can lead to increased daytime fatigue in the long term. Read More

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November 2018
2 Reads

[Frequency of restless legs syndrome and relationship between depression, anxiety and sleep quality among medical school students].

Tuberk Toraks 2018 Sep;66(3):217-223

Department of Chest Diseases, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.

Introduction: We aimed to investigate the relationship between frequency of restless legs syndrome (RLS), depression, anxiety and sleep quality among medical school students.

Materials And Methods: We applied a questionnaire to medical school students. This questionnaire includes some questions about demographic features of participants, questions related with RLS diagnosis, the pittsburgh sleep quality index (PSQI), beck-depression-scale (BDS), beck-anxiety scale (BAS) to all subjects. Read More

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September 2018
2 Reads

The Fever Tree: from Malaria to Neurological Diseases.

Authors:
Sara Eyal

Toxins (Basel) 2018 Nov 23;10(12). Epub 2018 Nov 23.

Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.

This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine. Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars. Over those 400 years, the medical use of cinchona alkaloids has evolved from bark extracts to chemical synthesis and controlled clinical trials. Read More

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November 2018
2 Reads

Ullanlinna Narcolepsy Scale in Diagnosis of Narcolepsy.

Sleep 2018 Nov 26. Epub 2018 Nov 26.

Helsinki Sleep Clinic, Vitalmed Research Centre, Finland.

Study Objectives: To validate Ullanlinna Narcolepsy Scale (UNS) as a screening tool for narcolepsy in a clinical population and to compare it with Swiss Narcolepsy Scale (SNS) and Epworth Sleepiness Scale (ESS).

Methods: UNS questionnaires of 267 subjects visiting Helsinki Sleep Clinic were analyzed. The diagnoses of the subjects were narcolepsy type 1 (NT1, n = 89), type 2 (NT2, n = 10), other hypersomnias (n = 24), sleep apnea (n = 37), restless legs or periodic limb movement disorder (n = 56), and other sleep-related disorders (n = 51). Read More

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November 2018
9 Reads

Neuroimaging Applications in Restless Legs Syndrome.

Int Rev Neurobiol 2018 22;143:31-64. Epub 2018 Oct 22.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, Unit of Neurology, University of Bologna, Bologna, Italy.

Neuroimaging studies provide information useful to understand the pathophysiology of restless legs syndrome. Molecular PET and SPECT imaging findings mainly supported dysfunction of dopaminergic pathways involving not only the nigrostriatal but also mesolimbic pathways. Magnetic resonance imaging (MRI) studies have used different techniques. Read More

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October 2018
4 Reads

Behavioral characterization of DAT-KO rats and evidence of asocial-like phenotypes in DAT-HET rats: The potential involvement of norepinephrine system.

Behav Brain Res 2018 Nov 22;359:516-527. Epub 2018 Nov 22.

Center for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Rome, Italy. Electronic address:

Dopamine (DA) is a key neurotransmitter of the central nervous system, whose availability is regulated by the dopamine transporter (DAT). Deletion of DAT gene leading to hyperdopaminergia was previously performed on mouse models. This enabled recapitulation of the core symptoms of Attention-Deficit / Hyper-activity Disorder (ADHD), which include hyperactivity, inattention and cognitive impairment. Read More

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November 2018
1 Read

Associations between sleep parameters, non-communicable diseases, HIV status and medications in older, rural South Africans.

Sci Rep 2018 Nov 23;8(1):17321. Epub 2018 Nov 23.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK.

As part of the Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI), we investigated sleep habits and their interactions with HIV or non-communicable diseases (NCDs) in 5059 participants (median age: 61, interquartile range: 52-71, 54% females). Self-reported sleep duration was 8.2 ± 1. Read More

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November 2018
2 Reads

Elevation of tumor necrosis factor alpha levels is associated with restless legs symptoms in clinically depressed patients.

J Psychosom Res 2018 Dec 21;115:1-5. Epub 2018 Sep 21.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Background: Restless legs syndrome is a sensorimotor disorder associated with several mental illnesses particularly depression.

Methods: A cross-sectional study of primary care patients. The prevalence of restless legs symptoms was studied in 706 patients with depressive symptoms and 426 controls without a psychiatric diagnosis by using a structured questionnaire. Read More

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December 2018
1 Read

Factors related to excessive sleepiness in patients with Parkinson's disease.

Neurol Res 2018 Nov 21:1-7. Epub 2018 Nov 21.

c Department of Neuroscience, Faculty of Medicine of Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.

Introduction: Excessive sleepiness (ES) can affect up to 60% of Parkinson's disease (PD) patients, and it has a multifactorial etiology. It is related to the neurodegenerative processes affecting brain regions responsible for the sleep-wake cycle, the effects of drugs acting on the central nervous system, and the excessive sleep fragmentation of this population.

Objectives: To identify the factors associated with the presence of ES in patients with PD. Read More

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November 2018
8 Reads

Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction.

Sleep Med 2018 Jun 26;53:81-87. Epub 2018 Jun 26.

Department of Neurology, Methodist Neurological Institute, Prof. Neurology Weill Cornell Medical School, Houston, TX, USA. Electronic address:

Background: Recent studies have suggested that cerebral ischemic infarction may contribute to the development of restless legs syndrome (RLS). This study analyzed the clinical and radiological profiles of RLS with onset after acute lacunar infarction.

Methods: In this retrospective study we enrolled 244 consecutive patients with acute lacunar infarction between January 2012 and June 2014. Read More

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June 2018
4 Reads

[A restless REM sleep may be sign of emerging neurodegenerative diseases].

Med Sci (Paris) 2018 Oct 19;34(10):771-773. Epub 2018 Nov 19.

Centre de recherche en neurosciences de Lyon (CRNL), équipe SLEEP, CNRS UMR5292, Inserm U1028, université Claude-Bernard-Lyon-1, 7 rue Guillaume Paradin, 69372 Lyon, France.

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October 2018
1 Read
0.520 Impact Factor

Restless legs syndrome and its variants in acute ischemic stroke.

Acta Neurol Scand 2018 Nov 18. Epub 2018 Nov 18.

Department of Neurology, Dokkyo Medical University, Tochigi, Japan.

Background: The clinical-radiological correlation between restless legs syndrome (RLS) or its variants and acute ischemic stroke remains unclear.

Methods: This study prospectively included 104 consecutive patients with acute ischemic stroke, confirmed by diffusion-weighted imaging. The frequency and clinical characteristics of RLS or RLS variants were evaluated according to the International RLS Study Group criteria, as was the topography of the associated lesions. Read More

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November 2018
5 Reads

Successful percutaneous treatment of osteoid osteoma in a 13 month-old boy with radiofrequency ablation under CT guidance.

Acta Orthop Traumatol Turc 2018 Nov 13. Epub 2018 Nov 13.

University of Health Sciences, Gaziosmanpasa Training and Research Hospital, Radiology Department, Turkey. Electronic address:

We present a 13-month-old boy who had a successful Computed Tomography (CT) guided percutaneous radiofrequency ablation (RFA) treatment for the osteoid osteoma (OO) on proximal part of the tibial diaphysis. The complaints of the patient were being restless due to pain and refusing to bear any weight on his left leg for 6 months. An asymmetrical cortical thickening and a focal sclerosis was detected on medial proximal diaphysis of the left tibia on radiographs and axial T2-weighted STIR-MR image showed bone marrow and soft-tissue edema with low-signal-intensity nidus due to central calcification with a high-signal-intensified unmineralized periphery. Read More

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November 2018
5 Reads

Differential Diagnosis and Treatment of Restless Legs Syndrome: A Literature Review.

Cureus 2018 Sep 13;10(9):e3297. Epub 2018 Sep 13.

Emergency, Palacios Community Hospital, Palacios, USA.

Restless legs syndrome (RLS) is a chronic neurological disorder affecting a growing number of people. Patients describe an irresistible urge to move their lower limbs in times of immobility. Due to its vague symptoms and similarity to other disorders, it has become increasingly difficult for primary care clinicians to properly diagnose and manage RLS. Read More

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September 2018
3 Reads

Sleep Posture Classification using a Convolutional Neural Network.

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:1-4

Sleep is a process of rest and renewal that is vital for humans. However, there are several sleep disorders such as rapid eye movement (REM) sleep behaviour disorder (RBD), sleep apnea, and restless leg syndrome (RLS) that can have an impact on a significant portion of the population. These disorders are known to be associated with particular behaviours such as specific body positions and movements. Read More

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July 2018
2 Reads

I contributes to increased motoneuron excitability in restless legs syndrome.

J Physiol 2018 Nov 14. Epub 2018 Nov 14.

Department of Clinical Neurophysiology, Medical School Göttingen, University of Göttingen, Göttingen, Germany.

Key Points: Restless legs patients complain about sensory and motor symptoms leading to sleep disturbances. Symptoms include painful sensations, an urge to move and involuntary leg movements. The responsible mechanisms of restless legs syndrome are still not known, although current studies indicate an increased neuronal network excitability. Read More

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November 2018
4 Reads

Efficacy of vitamin D replacement therapy in restless legs syndrome: a randomized control trial.

Sleep Breath 2018 Nov 14. Epub 2018 Nov 14.

Somnogen Canada Inc., College Street, Toronto, ON, Canada.

Purpose: Restless legs syndrome is a movement sleep disorder that may be linked to dopaminergic dysfunction and in which vitamin D may play a role. This 12-week randomized, placebo-controlled trial elucidated the efficacy of vitamin D supplements in decreasing restless legs syndrome symptom severity.

Methods: Thirty-five subjects with restless legs syndrome, diagnosed using the International Restless Legs Syndrome Study Group criteria, were enrolled. Read More

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November 2018
7 Reads

Evaluation of restless legs syndrome and sleep disorders in patients with psoriatic arthritis.

Z Rheumatol 2018 Nov 12. Epub 2018 Nov 12.

Department of Rheumatology, Necmettin Erbakan University, Konya, Turkey.

Objectives: Restless legs syndrome (RLS) is a neurological disease with a chronic course that is characterised by sleep disorders and sensorimotor impairment. The aim of this study was to evaluate the prevalence and severity of RLS in psoriatic arthritis (PSA) patients and those with psoriasis (P).

Patients And Methods: The study included 50 patients with psoriasis (28 females, 22 males), 50 PSA patients (33 females, 17 males) and 50 healthy control subjects (34 females, 16 males), and all 3 groups were matched with respect to age, gender and body mass index (BMI). Read More

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November 2018
6 Reads

A study for the mechanism of sensory disorder in restless legs syndrome based on magnetoencephalography.

Sleep Med 2018 Sep 22;53:35-44. Epub 2018 Sep 22.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; The Beijing Key Laboratory of Neuromodulation, Beijing, 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. Electronic address:

In spite of the relatively high incidence rate, the etiology and pathogenesis of restless legs syndrome (RLS) are still unclear. Long-term drug treatments fail to achieve satisfying curative effects, which is reflected by rebound and augmentation of related symptoms. An electrophysiological endophenotype experiment was done to investigate the mechanism of somatosensory disorder among RLS patients. Read More

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September 2018
1 Read
3.154 Impact Factor

Restless Legs Syndrome and Other Movement Disorders of Sleep-Treatment Update.

Curr Treat Options Neurol 2018 Nov 9;20(12):55. Epub 2018 Nov 9.

Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.

Purpose Of Review: The purpose of this review article is to summarize and discuss the recent advances in the treatment of restless legs syndrome (RLS), as well as REM sleep behavior disorder (RBD), and periodic leg movement disorder (PLMD).

Recent Findings: Traditionally, dopaminergic therapy has been considered the sole option for first-line treatment of RLS due to their impressive acute efficacy. Dopamine agonists such as oral pramipexole and ropinirole, as well as transdermal rotigotine are all effective treatment options. Read More

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November 2018
10 Reads

New tricks for an old dog: A repurposing approach of apomorphine.

Eur J Pharmacol 2018 Nov 2;843:66-79. Epub 2018 Nov 2.

Behavior and Basal Ganglia Research Unit (EA 4712), University of Rennes 1, Rennes, France; Institut des Neurosciences Cliniques de Rennes (INCR), Rennes, France; Movement Disorders Unit, Neurology Department, Pontchaillou University Hospital, Rennes, France.

Apomorphine is a 150-year old nonspecific dopaminergic agonist, currently indicated for treating motor fluctuations in Parkinson's disease. At the era of drug repurposing, its pleiotropic biological functions suggest other possible uses. To further explore new therapeutic and diagnostic applications, the available literature up to July 2018 was reviewed using the PubMed and Google Scholar databases. Read More

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November 2018
7 Reads

Comparative Sleep Disturbances in Myotonic Dystrophy Types 1 and 2.

Curr Neurol Neurosci Rep 2018 Oct 31;18(12):102. Epub 2018 Oct 31.

System Medicine Department, University of Rome Tor Vergata, Rome, Italy.

Purpose Of Review: To update current knowledge regarding sleep disturbances and myotonic dystrophies so as to better understand if sleep symptoms may help in the early recognition of the two genetic subtypes: myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2).

Recent Findings: Sleep-disordered breathing (SDB), restless legs syndrome, periodic limb movements in sleep, hypersomnia, and REM sleep dysregulation are frequently described in DM1 patients. SDB does not always explain hypersomnia, but a central dysregulation of sleep-wake modulation is reported mainly in DM1. Read More

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October 2018
4 Reads

Prevalence of sleep disorders and sleep problems in an elite super rugby union team.

J Sports Sci 2018 Oct 29:1-8. Epub 2018 Oct 29.

a Centre for Sleep Science, School of Human Sciences , The University of Western Australia , Crawley , WA , Australia.

The aim of this study was to determine the prevalence of sleep disorders in an elite rugby union team using in-laboratory polysomnography (PSG) and sleep questionnaires. Twenty-five elite rugby union players underwent a night of PSG during the "off-season" of the Super Rugby competition to assess their sleep. Of interest were measurements that detected the presence of obstructive sleep apnea (OSA; apnea-hypopnea index ≥5 events/hr) and the presence of moderate-severe periodic leg movements during sleep (PLMs; ≥15 events/hr). Read More

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October 2018
4 Reads

Investigating the association and causal relationship between restless legs syndrome and essential tremor.

Parkinsonism Relat Disord 2018 Oct 19. Epub 2018 Oct 19.

Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada. Electronic address:

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October 2018
1 Read

Erratum to "French Consensus: How to diagnose restless legs syndrome" [Rev. Neurol. 174 (7-8) (2018) 508-14].

Rev Neurol (Paris) 2018 12 23;174(10):756. Epub 2018 Oct 23.

Clinical neurophysiology, Inserm UMR 1171, teaching hospital, Lille university, 1, place de Verdun, 59045 Lille cedex, France. Electronic address:

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December 2018
8 Reads

Treatment of Comorbid Obstructive Sleep Apnea by Upper Airway Stimulation Results in Resolution of Debilitating Symptoms of Restless Legs Syndrome.

J Clin Sleep Med 2018 Oct 15;14(10):1797-1800. Epub 2018 Oct 15.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, Virginia.

Abstract: An association between restless legs syndrome (RLS) and obstructive sleep apnea (OSA) has been suggested for decades but has been questioned in recent years given the apparently similar prevalence of RLS among patients with OSA and the general population. Still, marked improvement in symptoms of RLS has been reported in patients with OSA treated with continuous positive airway pressure (CPAP). Whether the effect of OSA treatment on RLS extends to modalities of OSA treatment other than CPAP remains an open question. Read More

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October 2018
1 Read

Restless Legs Syndrome in NKX2-1-related chorea: An expansion of the disease spectrum.

Brain Dev 2018 Oct 20. Epub 2018 Oct 20.

Child Neurology and Psychiatry Unit, Santa Maria Nuova Hospital IRCCS, Reggio Emilia, Italy.

Background: Molecular technologies are expanding our knowledge about genetic variability underlying early-onset non-progressive choreic syndromes. Focusing on NKX2-1-related chorea, the clinical phenotype and sleep related disorders have been only partially characterized.

Methods: We propose a retrospective and longitudinal observational study in 7 patients with non-progressive chorea due to NKX2-1 mutations. Read More

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October 2018
8 Reads

Two early descriptions of restless legs syndrome by J. Astruc (1736) and M.A. Weikard (1796).

Neurology 2018 Oct;91(17):786-789

From the Departments of Hospital Pharmacy (T.L.) and Geriatric Medicine (C.L.), Ordensklinikum Linz Barmherzige Schwestern, Linz, Austria.

Objective: To find and analyze early descriptions of restless legs syndrome (RLS).

Methods: Databases and textbooks were searched to document the current knowledge on the history of RLS and to identify additional early descriptions of RLS.

Results: Two recently discovered early descriptions of RLS are presented together with a review of the current knowledge on the history of RLS. Read More

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October 2018
6 Reads

Sleep disorders in traumatic brain injury.

NeuroRehabilitation 2018 ;43(3):257-266

Department of Neurology Northwestern University, Chicago, IL, USA.

Background: Sleep disorders play a significant role in the care of those with Traumatic Brain Injury (TBI).

Objective: To provide a literature review on the interaction of sleep and circadian processes on those with TBI.

Methods: A literature review was conducted on PubMed using the following key words and their combination: "Sleep Apnea", "Traumatic Brain Injury", "Circadian", "Parasomnia", "Insomnia", "Hypersomnia", "Narcolepsy", and "Restless Legs". Read More

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January 2018
6 Reads

Clinical Sleep-Wake Disorders I: Focus on Hypersomnias and Movement Disorders During Sleep.

Handb Exp Pharmacol 2018 Oct 20. Epub 2018 Oct 20.

Department of Neurology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.

Central disorders of hypersomnolence are characterized by daily periods of irrepressible need to sleep or daytime lapses into sleep, as defined in the current version of the International Criteria of Sleep Disorders. Thus, the unifying symptom is excessive daytime sleepiness which is not caused by any other sleep-wake disorder. Relevant disorders including narcolepsy type 1 and 2, idiopathic hypersomnia, Kleine-Levin syndrome, and insufficient sleep syndrome will be discussed. Read More

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October 2018
8 Reads

Do you have restless leg syndrome? I understood from your eyes.

Sleep Breath 2018 Oct 19. Epub 2018 Oct 19.

Department of Neurology, Adatıp Private Hospital, Sakarya, Turkey.

Purpose: According to many studies in the literature, there is a strong association between restless leg syndrome and dopaminergic dysfunction. Dopamine is also the major catecholamine in the retina and is also a possible transmitter of the amacrine and interplexiform cells. The aim of this study is to investigate the possible association between RLS and retinal thickness. Read More

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October 2018
9 Reads

A Brief Report on a Reduced Preference for Passive-Avoidant Leadership After a Restless Night.

Front Psychol 2018 2;9:1888. Epub 2018 Oct 2.

Department of Psychosocial Science, University of Bergen, Bergen, Norway.

The purpose of this study is to investigate the effect of fragmented sleep on followers' leadership preferences. In a counterbalanced experimental study involving 39 followers, changes in leadership preferences were recorded after one night of fragmented sleep (awakened every 80 min during the night), compared to a rested condition with the conditions separated by seven nights. The results showed that the participants rated passive-avoidant leadership less ideal, after one night of fragmented sleep. Read More

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October 2018
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