4,538 results match your criteria Restless Legs Syndrome


The first night effect during polysomnography, and patients' estimates of sleep quality.

Psychiatry Res 2019 Feb 6;274:27-29. Epub 2019 Feb 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, South Korea. Electronic address:

We surveyed patients the next morning after in-laboratory polysomnography (PSG) to compare the first night effect (FNE) and reverse first night effect (RFNE) in different sleep disorders. A questionnaire was given to 852 patients with insomnia (n = 171), restless legs syndrome (n = 186), obstructive sleep apnea (n = 369), simple snoring (n = 54), REM sleep behavior disorder (n = 39), and hypersomnia (n = 33). FNE was seen in 48. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.011DOI Listing
February 2019

Reduced response to gabapentin enacarbil in restless legs syndrome following long-term dopaminergic treatment.

Sleep Med 2018 Dec 26;55:74-80. Epub 2018 Dec 26.

European Sleep Institute, Santiago, Chile. Electronic address:

Objectives: To determine whether long-term treatment with dopaminergic agents (DAs) might dampen the response to a non-dopaminergic agent, such as gabapentin enacarbil.

Methods: We performed a two-week randomized, double-blind, crossover, and placebo-controlled study in a single, referral center in dopamine treatment-naive patients and non-augmented patients continuously treated with dopaminergics for the last five consecutive years. Following washout from any previous CNS-active drugs, patients were randomized into one of two groups for two consecutive two-week treatment periods with gabapentin enacarbil (GBPen) and placebo. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.025DOI Listing
December 2018

Acceptability and feasibility of a 12-week yoga vs. educational film program for the management of restless legs syndrome (RLS): study protocol for a randomized controlled trial.

Trials 2019 Feb 15;20(1):134. Epub 2019 Feb 15.

Department of Epidemiology, West Virginia University School of Public Health, HSC N, PO Box 9190, Morgantown, WV, 26506, USA.

Background: Restless legs syndrome (RLS) is a common and burdensome sleep disorder associated with profound impairment of health, well-being, and quality of life. Unfortunately, the medications used for RLS management carry risk of serious side effects, including augmentation of symptoms. Yoga, an ancient mind-body discipline designed to promote physical, emotional, and mental well-being, may offer a viable, low-risk new treatment. Read More

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http://dx.doi.org/10.1186/s13063-019-3217-7DOI Listing
February 2019

Successful spinal cord stimulation for severe medication-refractory restless legs syndrome.

Mov Disord 2019 Feb 15. Epub 2019 Feb 15.

Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/mds.27644DOI Listing
February 2019

Restless Legs Syndrome Among Veterans With Spinal Cord Lesions.

Fed Pract 2018 Apr;35(Suppl 3):S17-S20

is a Neurologist with Noran Neurological Clinic in Minneapolis, Minnesota. is an Associate Professor of Neurology and Program Director of the Sleep Medicine Fellowship at the Mayo Clinic in Jacksonville, Florida. is an Associate Professor of Psychiatry at King Edward Medical University in Lahore, Pakistan. is the Medical Director at the Center for Sleep Medicine at the VA North Texas Health Care System and Associate Professor of Psychiatry and Neurology at the University of Texas Southwestern Medical Center in Dallas.

Researchers developed a restless legs syndrome questionnaire using diagnostic criteria to assess its prevalence among veterans with spinal cord injuries and disorders. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375435PMC

Serum Interleukin-6 is Not Linked with Sleep-Quality, Restless Legs Syndrome, and Depression, But with 6-Month Survival in Hematological Malignancies.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):94-100

Department of Psychiatry, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

Background: Serum interleukin (IL)-6 has been found to be associated with sleep quality, mood, and survival in patients with solid tumors. Results in these studies were confounded by knowledge of diagnosis to study subjects. Moreover, such data among subjects with hematological malignancies and data regarding restless legs syndrome is limited. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_159_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338000PMC
February 2019

Prevalence and Characteristics of Restless Legs Syndrome in Korean Adults: A Study in Two Independent Samples of the General Population.

Neuroepidemiology 2019 Feb 14;52(3-4):193-204. Epub 2019 Feb 14.

Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of

Background: Restless legs syndrome (RLS) is a common sleep disorder, although it has a low prevalence in Asian populations. However, the reported RLS prevalence in -Korean adults is mostly 4.5-12. Read More

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http://dx.doi.org/10.1159/000496839DOI Listing
February 2019

The Parkinson's disease and restless legs syndrome/Willis-Ekbom disorder link: evidences, biases and clinical relevance.

Arq Neuropsiquiatr 2019 Jan;77(1):47-54

Universidade Nove de Julho, São Paulo SP, Brasil.

Parkinson's disease (PD) and restless legs syndrome/Willis-Ekbom disorder (RLS/WED) are relatively common diseases in the realm of movement disorders. The fact that both may, as expected, co-occur and typically share a similar remarkable response to dopaminergic treatment raised the interest in exploration of additional shared features that throughout the years cruised fields as diverse as phenomenology, epidemiology, genetics, pathology, and clinical studies. In this review, we describe and critically examine the evidence and biases of a conceivable overlap of these two disorders, trying to shed light onto two main sources of confusion: (1) are PD and RLS/WED reciprocal risk factors? and (2) what are the main mimics of RLS/WED in PD? Read More

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http://dx.doi.org/10.1590/0004-282X20180125DOI Listing
January 2019

Sleep Complaints, Sleep and Breathing Disorders in Myotonic Dystrophy Type 2.

Curr Neurol Neurosci Rep 2019 Feb 9;19(2). Epub 2019 Feb 9.

Department of Clinical Medicine and Surgery, Section of Respiratory Diseases, University of Naples Federico II, Naples, Italy.

Purpose Of Review: To update the current knowledge concerning sleep complaints and breathing disorders in myotonic dystrophy type 2 (DM2) and to better understand if sleep and breathing symptoms may add a further clinical definition of DM2.

Recent Findings: Although DM2 has been poorly evaluated, the most relevant sleep disorders are sleep-disordered breathing (SDB) (37.5-66. Read More

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http://link.springer.com/10.1007/s11910-019-0924-0
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http://dx.doi.org/10.1007/s11910-019-0924-0DOI Listing
February 2019
2 Reads

[Restless legs syndrome from the perspective of psychiatry].

Authors:
Patricia Rubí G

Rev Med Chil 2018 Sep;146(9):1041-1049

Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.

Restless Legs Syndrome (RLS) or Willis-Ekbom Disease is an under-diagnosed chronic and progressive primary sensory-motor disorder. It can lead to severe sleep disturbances, a usual cause of consultation. It is characterized by an urgent need to move the legs in resting situations, a cardinal symptom that is usually accompanied by an unpleasant sensation in legs. Read More

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http://dx.doi.org/10.4067/s0034-98872018000901041DOI Listing
September 2018
2 Reads

[Sleep Disorders in Old Age].

Praxis (Bern 1994) 2019 Jan;108(2):125-130

1 Neurologische Klinik, Kantonsspital St. Gallen.

Sleep Disorders in Old Age Abstract. Sleep disorders increase with age. Older patients rarely complain about sleep disorders, therefore it is important to ask about sleep problems. Read More

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http://dx.doi.org/10.1024/1661-8157/a003171DOI Listing
January 2019
2 Reads

[Sleep Disturbances in General Practitioners' Offices: From Screening to Initial Therapy - Update 2019].

Praxis (Bern 1994) 2019 Jan;108(2):103-109

1 Klinik für Schlafmedizin, Bad Zurzach.

Sleep Disturbances in General Practitioners' Offices: From Screening to Initial Therapy - Update 2019 Abstract. The field of sleep medicine has established internationally as an interdisciplinary specialization. Due to prevailing evidence, sleep disturbances are listed in a separate chapter in the new ICD 11 classification system. Read More

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http://dx.doi.org/10.1024/1661-8157/a003166DOI Listing
January 2019
1 Read

Restless legs syndrome and iron deficiency in adults with attention deficit hyperactivity disorder.

Sleep 2019 Feb 5. Epub 2019 Feb 5.

National Reference Network for Narcolepsy, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, France.

Objective: The association between restless legs syndrome (RLS), periodic leg movements during sleep (PLMS) and iron deficiency has been reported in children with attention deficit/hyperactivity disorder (ADHD); however little is known in adults. The aim of this study was to assess frequencies of RLS, PLMS and other leg movements (LM) and iron deficiency and their relationships with ADHD phenotype in adults with ADHD.

Methods: 200 adults with ADHD (112 males, median age 31 years) were evaluated on lifetime ADHD symptoms and sleep characteristics. Read More

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http://dx.doi.org/10.1093/sleep/zsz027DOI Listing
February 2019
2 Reads

Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson's Disease.

Parkinsons Dis 2019 2;2019:1654161. Epub 2019 Jan 2.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson's disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS.

Objective: To delineate NMS in FDR of patients with different clinical types of PD. Read More

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http://dx.doi.org/10.1155/2019/1654161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334354PMC
January 2019
2 Reads

Therapeutic drug monitoring of gabapentin in various indications.

Acta Neurol Scand 2019 Feb 1. Epub 2019 Feb 1.

Department of Pharmacology, Oslo University Hospital, Oslo, Norway.

Objectives: Gabapentin has been increasingly used in various indications in recent years. Despite variable pharmacokinetics, therapeutic drug monitoring (TDM) is scarcely described in other indications than epilepsy. The aim of the study was to investigate the use and pharmacokinetic variability of gabapentin in epilepsy and non-epilepsy indications and to further evaluate the use of TDM in patients with restless legs syndrome (RLS). Read More

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http://dx.doi.org/10.1111/ane.13075DOI Listing
February 2019
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THE RESTLESS LEGS SYNDROME (REVIEW).

Georgian Med News 2018 Dec(285):74-81

Institute of Neurology and Neuropsychology, Tbilisi; Caucasus International University, Tbilisi; Ilia State University, Tbilisi, Georgia; Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.

The restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a common sleep related neurological disorder with prevalence between 1 and 10%, increasing with age. Women are more frequently affected than men. RLS is characterized by an urge to move the legs accompanied by uncomfortable and unpleasant sensations in the legs, worsening of complaints during periods of rest, improvement by movement and an increase of symptoms in the evening or at night. Read More

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December 2018
3 Reads

Restless legs syndrome in end-stage renal disease patients undergoing hemodialysis.

Arq Neuropsiquiatr 2018 Dec;76(12):827-830

Servicio de Neurología, Hospital Universitario "Dr. José E. González" Universidad Autónoma de Nuevo León; Monterrey, NL, México.

Objectives: Restless legs syndrome (RLS) is a frequent complication of hemodialysis that has been associated with poor quality of life and increased risk for complications. Nevertheless, few studies regarding this entity exist in resource-limited settings. To determine the prevalence of RLS among Mexican patients on hemodialysis; and compare these patients with a control group of the same population. Read More

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http://dx.doi.org/10.1590/0004-282X20180133DOI Listing
December 2018
1 Read

Exclusion of mimics does not influence Willis-Ekbom disease diagnosis among recent medical graduates.

Arq Neuropsiquiatr 2018 Dec;76(12):816-820

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia, Neuro-Sono, São Paulo SP, Brasil.

Objective: In view of the diagnostic challenge posed by restless legs syndrome/Willis-Ekbom disease (RLS/WED) to health professionals and the challenge of its recognition by patients, the diagnostic criteria have been revised and updated to facilitate identification of this disease. However, in a previous study, we found that self-diagnosis of RLS/WED depends on the very name used to describe the condition. To ascertain whether the presence of the fifth diagnostic criterion of the International Restless Legs Syndrome Study Group (IRLSSG), is necessary for RLS/WED diagnosis when the term "Willis-Ekbom disease" is used. Read More

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http://dx.doi.org/10.1590/0004-282X20180135DOI Listing
December 2018
2 Reads

Brain iron accumulation in a blood donor family with restless legs syndrome.

Rev Neurol 2019 Feb;68(3):107-110

Hospital General Universitario Gregorio Maranon, Madrid, Espana.

Introduction: The pathophysiology of restless legs syndrome (RLS) is complex. Secondary RLS with iron deficiency -which suggests disturbed iron homeostasis- remains to be elucidated.

Case Reports: We report the findings from a unique blood donor family with RLS. Read More

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February 2019
1 Read

Prevalence of restless legs syndrome in functional movement disorders: a case-control study from the Czech Republic.

BMJ Open 2019 Jan 21;9(1):e024236. Epub 2019 Jan 21.

Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital in Prague, Prague, Czech Republic.

Objectives: The prevalence of restless legs syndrome (RLS) in functional movement disorders (FMD) is not known. Patients with FMD often present with multiple motor and sensory symptoms. Some of these symptoms might be due to comorbid RLS. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347872PMC
January 2019
1 Read

Diagnostic Criteria, Differential Diagnosis, and Treatment of Minor Motor Activity and Less Well-Known Movement Disorders of Sleep.

Curr Treat Options Neurol 2019 Jan 19;21(1). Epub 2019 Jan 19.

Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Purpose Of Review: Sleep-related movement disorders (SRMD) include several different motor activities during sleep. Few of them are well known and well classified, whereas others are minor motor disorders of sleep which are neither thoroughly characterized and classified nor have been extensively investigated to clarify their pathogenesis and clinical relevance. This review will focus on those minor sleep-related movement disorders. Read More

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http://dx.doi.org/10.1007/s11940-019-0543-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339673PMC
January 2019
2 Reads

Patterns of gray matter alterations in migraine and restless legs syndrome.

Ann Clin Transl Neurol 2019 Jan 12;6(1):57-67. Epub 2018 Nov 12.

Department of Neurology Tri-Service General Hospital National Defense Medical Center Taipei Taiwan.

Objectives: Migraine and restless legs syndrome (RLS) are often comorbid and share elements of pathology; however, their neuroanatomical underpinnings are poorly understood. This study aimed to identify patterns of gray matter volume (GMV) alteration specific to and common among patients with RLS, migraine, and comorbid migraine and RLS.

Methods: High-resolution T1-weighted images were acquired from 116 subjects: 27 RLS patients, 22 migraine patients, 22 patients with comorbid migraine and RLS, and 45 healthy controls. Read More

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http://doi.wiley.com/10.1002/acn3.680
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http://dx.doi.org/10.1002/acn3.680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331309PMC
January 2019
5 Reads

Safety of dopamine agonists for treating restless legs syndrome.

Authors:
Howard D Weiss

Mov Disord 2019 Jan;34(1):150

Consultant in Neurology, Sinai Hospital, and Associate Professor of Neurology, Johns Hopkins Hospital, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/mds.27573DOI Listing
January 2019
1 Read
5.680 Impact Factor

A note on rotigotine for restless legs syndrome after renal transplantation.

Mov Disord 2019 Jan;34(1):151-152

Neurogenetics, Instituto de Investigación Sanitaria de Santiago-SERGAS Santiago de Compostela, Spain.

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http://dx.doi.org/10.1002/mds.27574DOI Listing
January 2019
1 Read

Reply to: Safety of dopamine agonists for treating restless legs syndrome.

Mov Disord 2019 Jan;34(1):150-151

Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.

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http://dx.doi.org/10.1002/mds.27571DOI Listing
January 2019
1 Read

The impact of the use of amalgam in dental treatment on the prevalence of restless legs syndrome in older people.

Med Pr 2018 Dec 21. Epub 2018 Dec 21.

Medical University of Lodz, Łódź, Poland (Department of Geriatrics, Healthy Ageing Research Centre).

Background: The link between restless legs syndrome (RLS) and the number of amalgam fillings in older people was investigated. Restless legs syndrome decreases the quality of life and impairs normal functioning. Mercury (in amalgam) may be toxic to nerve cells and may account for the incidence of RLS. Read More

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http://dx.doi.org/10.13075/mp.5893.00749DOI Listing
December 2018
1 Read

Screening of novel restless legs syndrome-associated genes in French-Canadian families.

Neurol Genet 2018 Dec 20;4(6):e296. Epub 2018 Dec 20.

Department of Human Genetics (F.A., Z.G.-O., G.A.R.), McGill University; Montreal Neurological Institute (F.A., D.S., A.D.-L., Z.G.-O., P.A.D., G.A.R.), McGill University; and Department of Neurology and Neurosurgery (Z.G.-O., P.A.D., G.A.R.), McGill University, Montréal, Quebec, Canada.

Objective: To examine whether any rare, protein-altering variants could be identified across 13 recently identified restless legs syndrome (RLS) loci in familial French-Canadian cases.

Methods: Whole-exome sequences from 7 large French-Canadian families (4-8 affected per family for a total of 38 cases) were examined for variants in any genes located within 1 Mb on either side of each locus.

Results: Among the 43 rare protein-altering variants identified, none segregated with RLS in the families. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305992PMC
December 2018
1 Read

Prevalence and risk factors for restless legs syndrome during pregnancy in a Northern Italian population.

J Obstet Gynaecol 2019 Jan 8:1-5. Epub 2019 Jan 8.

a Department of Obstetrics Gynecology and Neonatology , Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy.

The objective of the present study was to investigate the frequency and the risk factors for restless legs syndrome (RLS) during pregnancy in an Italian population rarely studied, in epidemiological studies on the syndrome. A total of 648 women (median age: 35 years; interquartile range: 32-38), who delivered on randomly selected days at the obstetric department of our hospital, were identified. One hundred and thirty-two women (20. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1
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http://dx.doi.org/10.1080/01443615.2018.1525341DOI Listing
January 2019
4 Reads

Alterations of Sub-cortical Gray Matter Volume and Their Associations With Disease Duration in Patients With Restless Legs Syndrome.

Front Neurol 2018 17;9:1098. Epub 2018 Dec 17.

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

The purpose of this study was to uncover the pathology of restless legs syndrome (RLS) by exploring brain structural alterations and their corresponding functional abnormality. Surface-based morphometry (SBM) and voxel-based morphometry (VBM) were performed to explore the alterations in cortical and sub-cortical gray matter volume (GMV) in a cohort of 20 RLS and 18 normal controls (NC). Furthermore, resting-state functional connectivity (RSFC) was also performed to identify the functional alterations in patients with RLS. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01098
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http://dx.doi.org/10.3389/fneur.2018.01098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304426PMC
December 2018
8 Reads

Sleep and Tibialis Anterior Muscle Activity in Mice With Mild Hypoxia and Iron Deficiency: Implications for the Restless Legs Syndrome.

Front Physiol 2018 17;9:1818. Epub 2018 Dec 17.

Laboratory of Physiological Regulations in Sleeping Mice, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Restless legs syndrome (RLS) is a neurological disorder that entails an urge to move with a circadian pattern during the evening/night. RLS may be accompanied by decreased sleep time and increased occurrence of periodic leg movements during sleep (PLMS), which involve bursts of tibialis anterior (TA) muscle electromyogram (EMG). Mild hypoxia and non-anemic iron deficiency, a highly prevalent nutritional deficiency, are relatively unexplored factors in RLS pathophysiology. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01818
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http://dx.doi.org/10.3389/fphys.2018.01818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304696PMC
December 2018
4 Reads

Restless Legs Syndrome in Pregnant Thai Women: Prevalence, Predictive Factors, and Natural Course.

J Clin Neurol 2019 Jan;15(1):97-101

Neurology Division, Department of Internal Medicine, Thammasat University (Rangsit Campus), Pathumthani, Thailand.

Background And Purpose: Restless legs syndrome (RLS) is a common sleep-related neurological disorder that affects the quality of sleep. This study aimed to estimate the prevalence, predictive factors, and natural course of RLS, and its effect on sleep quality in pregnant Thai women.

Methods: A cross-sectional study that included 214 pregnant women was performed. Read More

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http://dx.doi.org/10.3988/jcn.2019.15.1.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325358PMC
January 2019
1 Read

Modulation of specific components of sleep disturbances by simultaneous subthalamic and nigral stimulation in Parkinson's disease.

Parkinsonism Relat Disord 2018 Dec 28. Epub 2018 Dec 28.

Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. Electronic address:

Objective: To compare the effect of simultaneous deep brain stimulation of the subthalamic nucleus and substantia nigra pars reticulata (STN+SNr-DBS) to conventional subthalamic stimulation (STN-DBS) on sleep quality in Parkinson's disease (PD) patients.

Methods: The study was a single-center, randomized, double-blind, cross-over clinical trial to compare the effect of STN-DBS vs. combined STN+SNr-DBS on subjective measures of sleep quality. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2018.12.026DOI Listing
December 2018
2 Reads

Iron for the treatment of restless legs syndrome.

Cochrane Database Syst Rev 2019 01 4;1:CD007834. Epub 2019 Jan 4.

Department of Neurology, Emory University School of Medicine, 12 Executive Park Drive NE, Atlanta, USA, 30329.

Background: Restless legs syndrome (RLS) is a common neurologic disorder that is associated with peripheral iron deficiency in a subgroup of patients. It is unclear whether iron therapy is effective treatment for RLS.

Objectives: To evaluate the efficacy and safety of oral or parenteral iron for the treatment of restless legs syndrome (RLS) when compared with placebo or other therapies. Read More

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http://dx.doi.org/10.1002/14651858.CD007834.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353229PMC
January 2019
3 Reads

[Chinese expert consensus on the assessment and management of stroke-related sleep disorders].

Authors:

Zhonghua Nei Ke Za Zhi 2019 Jan;58(1):17-26

Stroke-related sleep disorders (SSD) are common symptoms after stroke, which are common but easily ignored. Studies have shown that sleep disorders in stroke patients would have negative impact on prognosis. However, there is still a lack of consensus and guidance on SSD evaluation and management worldwide. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.01.004DOI Listing
January 2019
2 Reads

Video-Polysomnographic Characterization of Sleep Movements in Children with Restless Sleep Disorder.

Sleep 2019 Jan 2. Epub 2019 Jan 2.

Sleep Research Centre, Oasi Research Institute - IRCCS, Troina, Italy.

Objective: Children with "restless sleep disorder" (RSD) were previously identified clinically and polysomnographically. In this study we attempt to characterize their sleep-related movements and describe them in terms of type of movement, duration and timing.

Methods: Video-polysomnography (vPSG) from 15 school-aged children with RSD, 15 sex- and age-matched children with restless legs syndrome (RLS) and 15 controls was reviewed for identification of sleep-related movements. Read More

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http://dx.doi.org/10.1093/sleep/zsy269DOI Listing
January 2019
1 Read

Hepato-cerebral hereditary hemochromatosis in a patient with restless legs syndrome.

Med Clin (Barc) 2018 Dec 24. Epub 2018 Dec 24.

Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, España; Grupo de Investigación de Trastornos del Metabolismo del Hierro, Instituto de Investigación Gregorio Marañón, Madrid, España.

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http://dx.doi.org/10.1016/j.medcli.2018.11.001DOI Listing
December 2018
1 Read

Decline in dopamine agonists prescribing and characteristics of drugs prescribed during ambulatory office visits for restless legs syndrome: the National Ambulatory Medical Care Survey 2007-2015.

Sleep Med 2019 Feb 26;54:238-243. Epub 2018 Nov 26.

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, USA.

Objective: To examine prescribing of drugs treating or exacerbating restless legs syndrome (RLS) during U.S. physician office visits for RLS for the years 2007-2015; and to assess potential prescribing predictors of these drugs. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.011DOI Listing
February 2019
2 Reads

Response to letter to Editor.

J Neurol Sci 2019 Feb 7;397:48-49. Epub 2018 Dec 7.

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jns.2018.12.008DOI Listing
February 2019
1 Read

Hypnagogic Foot Tremor, Alternating Leg Muscle Activation or High Frequency Leg Movements: clinical and phenomenological considerations in two cousins.

Sleep Med 2019 Feb 12;54:177-180. Epub 2018 Nov 12.

Department of Neurology, Sleep Laboratory, Medical University Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.sleep.2018.10.024DOI Listing
February 2019
1 Read

Corrigendum to "Evaluation of Acupuncture in the Treatment of Restless Legs Syndrome: A Randomized Controlled Trial" [J Acupunct Meridian Stud 10 (2017) 346-350].

J Acupunct Meridian Stud 2018 12 30;11(6):380. Epub 2018 Aug 30.

Neuromusculoskeletal Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.jams.2018.08.001DOI Listing
December 2018
1 Read

Restless legs syndrome in Parkinson's disease and increased cardiovascular risk.

Arq Neuropsiquiatr 2018 Nov;76(11):731-735

Hospital da Cruz Vermelha Brasileira Filial do Paraná, Departamento de Neurologia, Curitiba PR, Brasil.

Objective: Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RLS and increased cardiovascular risk and, so far, there are no consistent studies of this association in Parkinson's disease. To analyze the influence of RLS on cardiovascular risk in patients with Parkinson's disease. Read More

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http://dx.doi.org/10.1590/0004-282X20180114DOI Listing
November 2018
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Methodological considerations for measuring the association between restless legs syndrome and premotor symptoms of Parkinson's disease: An epidemiologic approach.

J Neurol Sci 2018 Dec 7. Epub 2018 Dec 7.

Division of Clinical Epidemiology, McGill University Health Centre, Allan Memorial Institute, 1025 Pine Ave West, Montreal, Quebec H3A 1A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2018.12.009DOI Listing
December 2018
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Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies.

Sleep 2018 Dec 14. Epub 2018 Dec 14.

Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-Universität Münster, Münster, Germany.

Study Objectives: Periodic limb movements in sleep (PLMS) are frequent motor phenomena; however, population-based data are scarce. We assessed the prevalence of PLMS and factors associated with PLMS within two German population-based cohorts, the SHIP-TREND and BiDirect.

Methods: Single-night polysomnography was performed on 1107 subjects recruited from the general population (mean age: 52. Read More

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http://dx.doi.org/10.1093/sleep/zsy237DOI Listing
December 2018
3 Reads

Restless Legs Syndrome in Children.

Pediatr Ann 2018 Dec;47(12):e504-e506

Restless legs syndrome (RLS) is a common pediatric condition that often goes undiagnosed. The genetics and pathophysiology of this sensorimotor condition are still not well understood. RLS can affect any part of the body, but the thighs and calves are the most commonly affected. Read More

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https://www.healio.com/doiresolver?doi=10.3928/19382359-2018
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http://dx.doi.org/10.3928/19382359-20181114-02DOI Listing
December 2018
14 Reads

Is there a relationship between restless legs syndrome and medical problems in pregnant women? A cross-sectional study in Iran.

Acta Neurol Belg 2018 Dec 12. Epub 2018 Dec 12.

Midwifery Department, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This study aimed to assess the relationship between RLS and medical problems among pregnant women. In this study, 700 pregnant women were recruited. A socio-demographic questionnaire and the International Restless Legs Questionnaire were used to gather information. Read More

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http://dx.doi.org/10.1007/s13760-018-01062-7DOI Listing
December 2018
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Gabapentin enacarbil for antipsychotic induced akathisia in schizophrenia patients: a pilot open-labeled study.

Neuropsychiatr Dis Treat 2018 22;14:3179-3184. Epub 2018 Nov 22.

Akita Prefectural Mental Health and Welfare Center, Akita City, Akita 010-0001, Japan.

Objective: Gabapentin and its prodrug are candidate therapeutic agents for akathisia. An open-label pilot study was conducted to investigate the therapeutic potential of gabapentin enacarbil (GE) for akathisia.

Methods: In an open-labeled investigator-initiated clinical trial, nine outpatients with antipsychotics-induced akathisia were administered GE (300 or 600 mg/day) over 2 weeks. Read More

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http://dx.doi.org/10.2147/NDT.S184081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257366PMC
November 2018
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Prenatal alcohol exposure and sleep-wake behaviors: exploratory and naturalistic observations in the clinical setting and in an animal model.

Sleep Med 2019 Feb 25;54:101-112. Epub 2018 Oct 25.

Department of Cellular & Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Introduction: Clinical research and studies using animal models have revealed a complex and relatively under-explored interaction between prenatal alcohol exposure (PAE) and alterations in sleep-wake behaviors.

Objectives: To utilize a structured naturalistic observation-based methodology, consisting of descriptive elements, to provide insight into possible links between altered sleep and disruptive daytime presentations in children and adolescents with fetal alcohol spectrum disorder (FASD). To apply a similar structured behavioral observation protocol in a PAE animal model to compare outcomes from the experimental and clinical studies utilizing naturalistic observational methodology. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.006DOI Listing
February 2019
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Validation of the self-administered version of the international Restless Legs Syndrome study group severity rating scale - The sIRLS.

Sleep Med 2019 Feb 29;54:94-100. Epub 2018 Oct 29.

The International Restless Legs Syndrome Study Group, Rochester, MN, USA.

Introduction: The International Restless Legs Study Group (IRLSSG) has developed the IRLS (International Restless Legs Syndrome Severity Scale) and validated it as a clinician/researcher administered scale to be used when both patient and examiner are present. The IRLSSG recognized the need for a self-completing scale that can be used economically in clinical practice and in large population-based studies. In this study the validity and the reliability of the IRLS as a self-administered scale (sIRLS) is assessed. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.10.014DOI Listing
February 2019
4 Reads