4,894 results match your criteria Restless Legs Syndrome


Prevalence and Clinical Characteristics of the Restless Legs Syndrome (RLS) in Patients Diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD) in Antioquia.

Int J Psychol Res (Medellin) 2018 Jan-Jun;11(1):58-69

Full member of the Colombian Association of Neurology (ACN) and Child Neurology Colombian Association (Asconi)-Group Director of Research in Child and Adolescent Disorders (PEDIACIENCIAS)-Titular Professor Department of Pediatrics, School of Medicine, Universidad de Antioquia, Medellín, Colombia. Universidad de Antioquia Department of Pediatrics School of Medicine Universidad de Antioquia Medellín Colombia.

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral issue for children. One of the sleeping disorders most frequently related to ADHD is the Restless Legs Syndrome (RLS), characterized by an irresistible urge to move the legs, something that is generally associated with paresthesias and motor restlessness. The prevalence rate of RLS in children diagnosed with ADHD is close to 18%, but in Colombia, these cases have been hardly studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21500/20112084.3381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110177PMC

Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.

Sleep Med Rev 2020 May 16;53:101339. Epub 2020 May 16.

The University of Sydney, Faculty of Science, School of Psychology, Sydney, New South Wales, Australia; Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Camperdown, New South Wales, Australia; The University of Sydney, Brain and Mind Centre, Sydney, New South Wales, Australia. Electronic address:

Cannabinoids, including the two main phytocannabinoids Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), are being increasingly utilised as pharmacological interventions for sleep disorders. THC and CBD are known to interact with the endocannabinoid and other neurochemical systems to influence anxiety, mood, autonomic function, and circadian sleep/wake cycle. However, their therapeutic efficacy and safety as treatments for sleep disorders are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.smrv.2020.101339DOI Listing

Effects of new PLM scoring rules on PLM rate in relation to sleep and resting wake for RLS and healthy controls.

Sleep Breath 2020 Jun 25. Epub 2020 Jun 25.

Christopher J Earley. Richard P Allen. Department of Neurology, School of Med., Johns Hopkins University, Baltimore, MD, USA.

Purpose: This study evaluates the differences in periodic leg movement (PLM) rates for Restless Legs Syndrome (RLS) and healthy controls when using the updated PLM scoring criteria developed by IRLSSG in 2016 versus the prior PLM scoring criteria developed by IRLSSG in 2006. Four major problems with the prior standards had been objectively identified, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11325-020-02134-wDOI Listing

Restless Legs Syndrome and Severe Preeclampsia: A Case-Control Study.

J Obstet Gynaecol Can 2020 Jun 20. Epub 2020 Jun 20.

Department of Obstetrics and Gynaecology, Saint Thomas Maternity Hospital, Panama City, Panama.

Objective: This study sought to determine whether there is an association between restless legs syndrome (RLS) and severe preeclampsia using a case-control study design.

Methods: A total of 147 patients with severe preeclampsia and 147 patients with normal pregnancies were evaluated for symptoms of RLS. In the first phase, before or immediately after delivery, participants were given a questionnaire on common complaints experienced during pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jogc.2020.01.019DOI Listing

SKOR1 has a transcriptional regulatory role on genes involved in pathways related to restless legs syndrome.

Eur J Hum Genet 2020 Jun 22. Epub 2020 Jun 22.

Department of Human Genetics, McGill University, Montréal, QC, Canada.

Restless legs syndrome (RLS) is a common sleep-related sensory-motor disorder. It is characterized by uncomfortable sensations in the legs during the evening or at night. The symptoms can be partially relieved by movement, so typically affected individual needs to walk during rest time; this interferes with sleep. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-020-0670-4DOI Listing

Antidepressants and movement disorders: a postmarketing study in the world pharmacovigilance database.

BMC Psychiatry 2020 Jun 16;20(1):308. Epub 2020 Jun 16.

Service de Pharmacologie Médicale et Clinique, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CHU de Toulouse, Faculté de Médecine, Toulouse, France.

Background: Antidepressants-induced movement disorders are rare and imperfectly known adverse drug reactions. The risk may differ between different antidepressants and antidepressants' classes. The objective of this study was to assess the putative association of each antidepressant and antidepressants' classes with movement disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12888-020-02711-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298955PMC

The urge to move: From restless legs syndrome to impulse control disorders in Parkinson's disease.

J Sleep Res 2020 Jun 15:e13127. Epub 2020 Jun 15.

EA7280 NPsy-Sydo, Clermont-Ferrand University Hospital, Neurology Department, Université Clermont Auvergne, Clermont-Ferrand, France.

Impulse control disorders (ICDs) in Parkinson's disease (PD) are defined as a failure to resist an "urge" to behave in a way that may be debilitating for oneself or others. The suggested immobilization test (SIT) has been developed to assess the "urge" to move and support the diagnosis of restless legs syndrome (RLS) in the general population and in PD. A clinical association between RLS and ICDs has been shown in PD and in the general population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jsr.13127DOI Listing

Topiramate-Associated Movement Disorder: Case Series and Literature Review.

Clin Neuropharmacol 2020 Jun 11. Epub 2020 Jun 11.

Medicine Department, Federal University of Santa Maria, Santa Maria, Brazil.

Background: Topiramate (TPM) is a fructose derivative, which was originally developed as an antiepileptic. In this context, movement disorders (MDs) are possible adverse events secondary to TPM.

Case Reports: Two patients (cases 1 and 2) developed myoclonus, and the other 2 had restless leg syndrome (RLS, cases 3 and 4). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNF.0000000000000395DOI Listing

Restless legs syndrome, sleep quality, and perceived cognitive impairment in adults with multiple sclerosis.

Mult Scler Relat Disord 2020 May 18;43:102176. Epub 2020 May 18.

Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL USA.

Background: Restless Legs Syndrome (RLS) is a prominent sleep disorder that often worsens sleep quality and perhaps cognitive function in adults with multiple sclerosis (MS). The present study examined the relationships among RLS prevalence and severity, sleep quality, and perceived cognitive impairment in adults with MS.

Methods: Participants (N=275) completed the Cambridge-Hopkins Restless Legs Syndrome Questionnaire, the International Restless Legs Syndrome Study Group (IRLS) Scale, the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ), the Pittsburgh Sleep Quality Index (PSQI), the Patient Determined Disease Steps (PDDS), and a demographic and clinical characteristics questionnaire. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2020.102176DOI Listing

[Drug-induced restless legs syndrome].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(4):129-135

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Restless legs syndrome (RLS) is a sensorimotor disorder characterized by complaints of a strong desire to move legs during periods of rest or inactivity, which is relieved by movement (most pronounced in the evening or at night). Multiple studies have reported drug-induced RLS caused by antipsychotics, antidepressants and antiepileptic medications. Risk factors for drug-induced RLS include older age, gastrointestinal diseases, high medication dose, simultaneous use of ≥2 drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/jnevro2020120041129DOI Listing
January 2020

Structural neuroimaging findings in migraine patients with restless legs syndrome.

Neuroradiology 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Purpose: One out of three migraine patients might have accompanying restless legs syndrome (RLS). In our study, we aimed to compare the volumes of the brain structures of migraineurs with and without RLS.

Methods: We had 37 female patients with migraine and 17 females as the control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00234-020-02451-7DOI Listing

Serum Glycomics Profiling of Patients with Primary Restless Legs Syndrome (RLS) using LC-MS/MS.

J Proteome Res 2020 Jun 2. Epub 2020 Jun 2.

Restless legs syndrome (RLS), also known as Willis-Ekbom Disease, is a sleep and neurological sensorimotor disorder. The prevalence of RLS is at ~ 5%-15% in the general population. RLS could severely impact the daytime work productivity and the life quality of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.9b00549DOI Listing

Hypothyroidism in restless legs syndrome.

J Sleep Res 2020 Jun 1:e13091. Epub 2020 Jun 1.

Department of Neurology, Yale University, New Haven, Connecticut, USA.

The diurnal nature of restless legs syndrome (RLS) and its response to dopamine hint that hormones are central in RLS pathophysiology. Hypothyroidism has been linked to RLS, but studies are limited. This study's objective is to determine whether RLS is more prevalent in persons with hypothyroidism and whether hypothyroidism is more prevalent in RLS sufferers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jsr.13091DOI Listing
June 2020
3.347 Impact Factor

'Is RLS a harbinger and consequence of MS?: Striking results of the 'RELOMS-T' study'.

Mult Scler Relat Disord 2020 Jul 16;42:102055. Epub 2020 Mar 16.

Dokuz Eylül University, Izmir, Turkey.

Background: Although studies report a high prevalence rate of restless legs syndrome (RLS) among patients with multiple sclerosis (PwMS) ranging from 13.3 to 65.1%, little is known about the causes of this relationship. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2020.102055DOI Listing

Sleep Disorders and Restless Legs Syndrome in Hemodialysis Patients in Greece: A Cross-Sectional Study.

Adv Exp Med Biol 2020 ;1195:155-162

General Hospital of Nikaia "AgiosPanteleimon", Nikaia, Greece.

Introduction: Sleep disorders, including insomnia and extreme sleep times, adversely affect the risk of developing illnesses and contribute to increased mortality rates. The aim of the study was to investigate sleep disorders experienced by hemodialysis patients in order to draw useful conclusions and to propose solutions to address this serious problem.

Material And Method: This is a cross-sectional study, and the study sample consisted of 120 patients undergoing hemodialysis from February to April 2017 at a general hospital in Greece. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-32633-3_21DOI Listing
January 2020

BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome.

Brain Struct Funct 2020 Jul 28;225(6):1743-1760. Epub 2020 May 28.

Department of Neurology, Norman Fixel Institute for Neurological Diseases, College of Medicine, University of Florida, PO Box 100236, Gainesville, FL, 32610-0236, USA.

Restless legs syndrome (RLS) is characterized by an urge to move legs, usually accompanied by uncomfortable sensations. RLS symptoms generally happen at night and can be relieved by movements. Genetic studies have linked polymorphisms in BTBD9 to a higher risk of RLS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00429-020-02090-xDOI Listing

Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation.

Int J Environ Res Public Health 2020 May 22;17(10). Epub 2020 May 22.

Neurophysiopathology Unit, Foundation IRCCS Carlo Besta Neurological Institute, 20133 Milan, Italy.

Restless legs syndrome is a common but still underdiagnosed neurologic disorder, characterized by peculiar symptoms typically occurring in the evening and at night, and resulting in sleep disruption and daily functioning impairment. This disease can affect subjects of all age ranges and of both sexes, manifesting itself with a broad spectrum of severity and deserving special attention in certain patient categories, in order to achieve a correct diagnosis and an effective treatment. The diagnosis of restless legs syndrome can be challenging in some patients, especially children and elderly people, and an effective treatment might be far from being easy to achieve after some years of drug therapy, notably when dopaminergic agents are used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17103658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277795PMC

Novel Coronavirus (COVID-19)-Associated Guillain-Barré Syndrome: Case Report.

J Clin Neuromuscul Dis 2020 06;21(4):240-242

Department of Neurology and Neuroscience Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CND.0000000000000309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273962PMC

Restless legs syndrome, sleep over the lifespan, sleep in the severely ill, shift-work and sleep loss.

Authors:
Dieter Riemann

J Sleep Res 2020 Jun;29(3):e13072

Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jsr.13072DOI Listing

The Role of BTBD9 in the Cerebellum, Sleep-like Behaviors and the Restless Legs Syndrome.

Neuroscience 2020 May 22;440:85-96. Epub 2020 May 22.

Norman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address:

Recent genome-wide association studies (GWAS) have found cerebellum as a top hit for sleep regulation. Restless legs syndrome (RLS) is a sleep-related sensorimotor disorder characterized by uncomfortable sensations in the extremities, generally at night, which are often relieved by movements. Clinical studies have found that RLS patients have structural and functional abnormalities in the cerebellum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2020.05.021DOI Listing

Thermo-therapy and cryotherapy to decrease the symptoms of restless leg syndrome during the pregnancy: A randomized clinical trial.

Complement Ther Med 2020 May 19;50:102409. Epub 2020 Apr 19.

Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Imam Khomeini Street, Taleghani Hospital, Arak, Iran. Electronic address:

Background And Purpose: Restless legs syndrome (RLS) is a common sensory-motor disorder among the pregnant women. The aim of this study is to compare the impacts of two methods of immersion of legs in cold and warm water on the RLS symptoms among the pregnant women.

Methods: This randomized clinical trial was conducted on 80 pregnant women with RLS who referred to Taleghani educational-therapy center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctim.2020.102409DOI Listing

Better Objective Sleep Was Associated with Better Subjective Sleep and Physical Activity; Results from an Exploratory Study under Naturalistic Conditions among Persons with Multiple Sclerosis.

Int J Environ Res Public Health 2020 May 18;17(10). Epub 2020 May 18.

Center of Affective, Stress and Sleep Disorders (ZASS), University of Basel, Psychiatric Clinics (UPK), 4002 Basel, Switzerland.

Persons with multiple sclerosis (PwMS) often complain about sleep problems. There is less known about objective sleep-electroencephalography (EEG) dimensions within naturalistic conditions (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17103522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277668PMC

CSF and serum ferritin levels in narcolepsy type 1 comorbid with restless legs syndrome.

Ann Clin Transl Neurol 2020 06 20;7(6):924-931. Epub 2020 May 20.

Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, Montpellier, France.

Objectives: To investigate whether cerebrospinal fluid (CSF) and serum ferritin levels differ between patients with narcolepsy type 1 (NT1) comorbid with restless legs syndrome (RLS) or periodic leg movements during sleep (PLMS), and patients with NT1 or controls without comorbid RLS or PLMS.

Methods: Sixty-six drug-free patients with NT1 (44 males, age 38.5 years [14-81]) were enrolled, including 20 with RLS, 18 with PLMS index ≥15/h (six with both RLS and PLMS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.51056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317640PMC

Tools for the Assessment of Pediatric Restless Legs Syndrome.

Front Psychiatry 2020 5;11:356. Epub 2020 May 5.

Sleep Division, Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, United States.

Background: There are only a few of the questionnaires for the diagnosis, severity and quality of life of adult Restless Legs Syndrome (RLS) that have been utilized in children. Even fewer of these types of instruments have been developed specifically for Pediatric RLS.

Methods: This article is a review of instruments used in adult RLS, their applicability to children and of instruments specifically developed for childhood RLS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2020.00356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214695PMC

The prevalence of restless legs syndrome in patients undergoing coronary angiography and its relationship with the severity of coronary artery stenosis.

Sleep Breath 2020 May 19. Epub 2020 May 19.

Faculty of Medicine, Department of Neurology, Tokat Gaziosmanpasa University, Kaleardi mah. Muhittin Fusunoglu cad, 60100, Tokat, Turkey.

Purpose: Results from studies on the relationship between restless legs syndrome (RLS) and coronary artery disease (CAD) are conflicting. Some studies associate RLS with CAD by heart rate variability, blood pressure variability, and other autonomic, neuronal reasons, while other studies do not support these observations. The aim of this study was to investigate the prevalence of RLS in patients undergoing coronary angiography for CAD and to assess RLS prevalence with severity of CAD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11325-020-02085-2DOI Listing

Correlates of Nonanemic Iron Deficiency in Restless Legs Syndrome.

Front Neurol 2020 30;11:298. Epub 2020 Apr 30.

Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Iron deficiency anemia (IDA) is a well-known cause of secondary restless legs syndrome (RLS). Iron deficiency without anemia (IDNA) is insidious, and its association with RLS is less evaluated. We investigate prevalence and features of IDNA in a consecutive cohort of patients with RLS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2020.00298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205016PMC

Mu opioid receptor knockout mouse: Phenotypes with implications on restless legs syndrome.

J Neurosci Res 2020 Aug 19;98(8):1532-1548. Epub 2020 May 19.

Norman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.

Restless legs syndrome (RLS) is characterized by an irresistible need to move the legs while sitting or lying at night with insomnia as a frequent consequence. Human RLS has been associated with abnormalities in the endogenous opioid system, the dopaminergic system, the iron regulatory system, anemia, and inflammatory and auto-immune disorders. Our previous work indicates that mice lacking all three subtypes of opioid receptors have a phenotype similar to that of human RLS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jnr.24637DOI Listing

The Link Between Amitriptyline and Movement Disorders: Clinical Profile and Outcome.

Ann Acad Med Singapore 2020 Apr;49(4):236-251

Medicine Department, Federal University of Santa Maria, Brazil.

Introduction: Amitriptyline (AMT) is a tricyclic antidepressant. In this review, we evaluate the clinical and epidemiological profile, pathological mechanisms and management of AMT-associated movement disorders.

Materials And Methods: A search for relevant reports in 6 databases was performed. Read More

View Article

Download full-text PDF

Source

The convenient use of fluorescamine for spectrofluorimetric quantitation of pramipexole in pure form and pharmaceutical formulation; application to content uniformity testing.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Sep 26;238:118414. Epub 2020 Apr 26.

Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, 62514 Beni-Suef, Egypt; Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Beni-Suef University, 62514 Beni-Suef, Egypt.

Pramipexole is a selective dopamine receptor agonist which is used in the treatment of Parkinson's disease and restless legs syndrome. The present work illustrates the development and validation of a sensitive and selective spectrofluorometric method for quantitation of pramipexole (PMP) through its interaction with fluorescamine at pH 7.5 using aqueous borate buffer to produce a highly fluorescent product. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118414DOI Listing
September 2020
2.353 Impact Factor

Quality improvement and practice-based research in sleep medicine using structured clinical documentation in the electronic medical record.

Sleep Sci Pract 2020 Jan;4

Department of Neurology, NorthShore University HealthSystem, 2650 Ridge Ave, Evanston, IL 60201, USA.

Background: We developed and implemented a structured clinical documentation support (SCDS) toolkit within the electronic medical record, to optimize patient care, facilitate documentation, and capture data at office visits in a sleep medicine/neurology clinic for patient care and research collaboration internally and with other centers.

Methods: To build our SCDS toolkit, physicians met frequently to develop content, define the cohort, select outcome measures, and delineate factors known to modify disease progression. We assigned tasks to the care team and mapped data elements to the progress note. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s41606-019-0038-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213673PMC
January 2020

Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome.

Sleep Med Clin 2020 Jun;15(2):277-288

Center for Sleep and Wake Disorders, Haaglanden Medical Center, The Hague, The Netherlands. Electronic address:

This article provides an updated practical guide for the treatment of primary restless legs syndrome (RLS). Articles that appeared after the American Academy of Neurology guideline search were reviewed according to the same evidence rating schedule. We found limited evidence for nonpharmacologic treatment options. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsmc.2020.02.013DOI Listing

Response to: restless legs syndrome in children.

Sleep Med 2020 Apr 14. Epub 2020 Apr 14.

Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sleep.2020.04.002DOI Listing

The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.

Nutrients 2020 May 5;12(5). Epub 2020 May 5.

Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria.

: Besides anemia, iron deficiency may cause more subtle symptoms, including the restless legs syndrome (RLS), the chronic fatigue syndrome (CFS) or sleeping disorders. : The aim of this pre-planned secondary analysis of the IronWoMan randomized controlled trial (RCT) was to compare the frequency and severity of symptoms associated with iron deficiency before and after (intravenous or oral) iron supplementation in iron deficient blood donors.

Methods/design: Prospective, randomized, controlled, single-centre trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu12051313DOI Listing

Alterations in Salience Network Functional Connectivity in Individuals with Restless Legs Syndrome.

Sci Rep 2020 May 6;10(1):7643. Epub 2020 May 6.

Department of Neurology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu, South Korea.

Background And Purpose: Restless legs syndrome (RLS) is a neurological disorder which is most commonly identified by an urge to move the legs. It often shows alterations in sensory processing which implies the salience network (SN) is experiencing changes. This study investigates the functional connectivity (FC) between the SN and other areas of the brain in RLS patients during the resting state period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-64641-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203171PMC

Prescribing in renal supportive care.

Authors:
Kelly Li Mark Brown

Aust Prescr 2020 Apr 1;43(2):57-60. Epub 2020 Apr 1.

Renal Medicine, St George Hospital, Sydney.

Renal Supportive Care Incorporates The Principles Of Palliative Care Into The Management Of Patients With Advanced Kidney Disease Its Focus Is On Improving The Quality Of Life For Patients With A High Burden Of Symptoms:

Common Problems Include Pain Restless Legs Syndrome And Uraemic Pruritus Symptom Management Must Involve Patient Participation Education And Non-pharmacological Strategies To Address Both Physical And Psychosocial Problems And To Prioritise Patient-centred Goals:

The Patients Are Medically Complex And Polypharmacy Is Common When Prescribing It Is Important To Consider The Altered Pharmacokinetics Potential Drug Interactions And The Clearance Of Drugs By Dialysis: Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18773/austprescr.2020.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186271PMC

Sleep apnea syndrome comorbid with and without restless legs syndrome: differences in insomnia specific symptoms.

Sleep Breath 2020 Apr 25. Epub 2020 Apr 25.

Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93052, Regensburg, Germany.

Objective: Sleep Apnea Syndrome (SAS) is frequently comorbid with Restless Legs Syndrome (RLS). Both disorders are associated with disturbed sleep. However, data about insomnia specific symptoms in patients suffering from both sleep disorders (SAS-RLS) are rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11325-020-02063-8DOI Listing

EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke.

Eur J Neurol 2020 Jul 20;27(7):1117-1136. Epub 2020 Apr 20.

Leeds Teaching Hospital NHS Trust, Leeds, UK.

Background: Sleep disorders are highly prevalent in the general population and may be linked in a bidirectional fashion to stroke, which is one of the leading causes of morbidity and mortality.

Aim: Four major scientific societies established a task force of experts in neurology, stroke, respiratory medicine, sleep medicine and methodology to critically evaluate the evidence regarding potential links and the impact of therapy.

Materials And Methods: Thirteen research questions were evaluated in a systematic literature search using a stepwise hierarchical approach: first, systematic reviews and meta-analyses; second, primary studies post-dating the systematic reviews/meta-analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ene.14201DOI Listing

Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy.

Fluids Barriers CNS 2020 Apr 16;17(1):28. Epub 2020 Apr 16.

Department of Neurology, Emory University, Atlanta, GA, USA.

Background: Iron is crucial for proper functioning of all organs including the brain. Deficiencies and excess of iron are common and contribute to substantial morbidity and mortality. Whereas iron's involvement in erythropoiesis drives clinical practice, the guidelines informing interventional strategies for iron repletion in neurological disorders are poorly defined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12987-020-00190-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161256PMC

Evaluation of upper endoscopic findings in patients with restless legs syndrome and gastric complaints.

Arq Neuropsiquiatr 2020 Apr;78(4):217-223

Uşak Univerrity School of Medicine, Department of Internal Medicine, Uşak, Turkey.

Background: The effect of gastrointestinal system disorders on Restless Legs Syndrome/Willis-Ekbom disease (RLS/WED) has been previously demonstrated by using serological tests. However, this association has not been supported by histopathological studies so far.

Objective: To investigate the relationship between RLS/WED, upper endoscopic imaging and histopathological results in patients diagnosed with RLS who underwent endoscopy because of gastrointestinal system (GIS) complaints. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0004-282X20190192DOI Listing

The prevalence of Restless Legs Syndrome/Willis-ekbom disease (RLS/WED) in the third trimester of pregnancy: a systematic review.

BMC Neurol 2020 Apr 13;20(1):132. Epub 2020 Apr 13.

Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: RLS is known as one of the most common movement disorders during pregnancy, which is most aggravated in the third trimester of pregnancy and can affect up to one-third of pregnant women. This study intends to determine the total prevalence of RLS in the third trimester of pregnancy through a systematic review.

Methods: The present study was conducted via meta-analysis method up to 2019. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12883-020-01709-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153235PMC
April 2020
2.040 Impact Factor

The prevalence of common sleep disorders in young adults: a descriptive population-based study.

Sleep 2020 Apr 13. Epub 2020 Apr 13.

Centre for Sleep Science, School of Human Sciences, University of Western Australia, Nedlands, Australia.

Sleep disorders in adults are associated with adverse health effects including reduced quality of life and increased mortality. However, there is little information on sleep disorders in young adults. A cross-sectional observational study was undertaken in 1,227 young adults participating in the Western Australian Pregnancy (Raine) Study (2012-2014) to describe the prevalence of common sleep disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/sleep/zsaa072DOI Listing

Comparison of prevalence rates of restless legs syndrome, self-assessed risks of obstructive sleep apnea, and daytime sleepiness among patients with multiple sclerosis (MS), clinically isolated syndrome (CIS) and Neuromyelitis Optica Spectrum Disorder (NMOSD).

Sleep Med 2020 Jun 17;70:97-105. Epub 2019 Dec 17.

University of Basel, Psychiatric Clinics (UPK), Center of Affective, Stress and Sleep Disorders (ZASS), Basel, Switzerland; Kermanshah University of Medical Sciences (KUMS), Sleep Disorders Research Center, Kermanshah, Iran; Kermanshah University of Medical Sciences (KUMS), Substance Abuse Prevention Research Center, Health Institute, Kermanshah, Iran; University of Basel, Department of Sport, Exercise, and Health, Division of Sport Science and Psychosocial Health, Basel, Switzerland; Tehran University of Medical Sciences, School of Medicine, Tehran, Iran.

Background: Prevalence rates for restless legs syndrome (RLS) and risk of Obstructive Sleep Apnea (OSA) in individuals with Neuromyelitis Optica Spectrum Disorder (NMOSD) and Clinically Isolated Syndrome (CIS) are unknown. The aims of the present study were to assess symptoms of RLS and self-assessed risks of OSA in individuals with NMOSD and CIS, to compare these prevalence rates with those of persons with multiple sclerosis (MS), and to associate RLS and OSA with expanded disability status scale (EDSS) scores, daytime sleepiness, fatigue, paresthesia, and medication.

Methods: A total of 495 individuals (mean age = 34. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sleep.2019.11.1266DOI Listing
June 2020
3.154 Impact Factor

Increased Gray Matter Density and Functional Connectivity of the Pons in Restless Legs Syndrome.

Nat Sci Sleep 2020 24;12:221-230. Epub 2020 Mar 24.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, People's Republic of China.

Background: Neurophysiological and radiological studies provide accumulating evidence for the involvement of the brainstem in the pathogenesis of restless legs syndrome (RLS). The analysis of the various subregions of the brainstem may help us better understand the pathophysiological mechanisms underlying the disorder. In this study, we investigated the structural and functional changes in the various subregions of the brainstem in RLS patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/NSS.S239852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102916PMC

The Impact of Deep Brain Stimulation on Sleep in Parkinson's Disease: An update.

J Parkinsons Dis 2020 ;10(2):393-404

Department of Neurology, University of California, San Francisco, CA, USA.

Background: Parkinson's disease (PD) can have a significant impact on sleep. Deep brain stimulation (DBS) is an effective treatment for motor features of PD, but less is understood about the impact DBS may have on sleep architecture and various sleep issues commonly seen in PD.

Objective: To review the impact of DBS on various sleep issues in PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JPD-191862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242854PMC
January 2020

Emerging Concepts of the Pathophysiology and Adverse Outcomes of Restless Legs Syndrome.

Chest 2020 Apr 2. Epub 2020 Apr 2.

Sleep Research Institute, Madrid. Electronic address:

Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED), is a common neurological disorder affecting up to 5% to 10% of the population, but it remains an underdiagnosed condition. RLS/WED is characterized by uncomfortable sensations, mainly in the legs, which appear during inactivity and worsen in the evening or at night. The prevalence of RLS/WED and periodic leg movements (PLMs) is increased in patients with sleep-disordered breathing, particularly in those with OSA, the most common sleep disorder encountered in sleep centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chest.2020.03.035DOI Listing

Randomized pilot trial for the efficacy of the MMF07 foot massager and heat therapy for restless legs syndrome.

PLoS One 2020 2;15(4):e0230951. Epub 2020 Apr 2.

Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.

Background: Restless Legs Syndrome (RLS) is a sensorimotor condition with a wide range of severity. Symptoms negatively affect sleep and quality of life. Pharmacologic options are not universally effective and side effects are common. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230951PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117678PMC

Therapeutic effect of high-efficiency online hemodiafiltration for recurrent restless legs syndrome in dialysis patients.

J Artif Organs 2020 Mar 30. Epub 2020 Mar 30.

Hashimoto Clinic, 3-21-5 Hashimoto Midori-ku, Sagamihara, Kanagawa, 252-0143, Japan.

Two dialysis patients developed recurrent restless legs syndrome. The clinical courses and the association between the α-microglobulin removal rate and the therapeutic effects of hemodiafiltration were analyzed. Case 1: a middle-aged woman was switched from predilution online hemodiafiltration to hemodialysis, following which the α-microglobulin removal rate decreased from 39. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10047-020-01164-1DOI Listing

Acute post-stroke restless legs syndrome: the body of caudate nucleus considerations.

Sleep Med 2020 Jun 19;70:66-70. Epub 2019 Dec 19.

Department of Neurology, Tangshan Gongren Hospital, Tangshan, Hebei, 063000, PR China. Electronic address:

Objectives: To investigate the relationship between the lesion location and post-stroke restless legs syndrome (RLS).

Methods: A total of 376 patients with acute cerebral infarction were recruited from Tangshan Gongren Hospital, Department of Neurology between May 2016 and May 2017, all of whom were evaluated for RLS. Established RLS was diagnosed according to the criteria of the International Restless Legs Syndrome Study Group (IRLSSG) in 2012. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sleep.2019.11.1253DOI Listing

Iron deficiency and sleep - A scoping review.

Sleep Med Rev 2020 Jun 8;51:101274. Epub 2020 Feb 8.

H-Behaviours Research Lab (Previously Sleep/Wake-Behaviours Research Lab), BC Children's Hospital Research Institute, Department of Pediatrics, University of British Columbia, Vancouver, Canada; Divisions of Developmental Pediatrics & Child and Adolescent Psychiatry, BC Children's Hospital, Department of Pediatrics, University of British Columbia, Vancouver, Canada. Electronic address:

Iron deficiency (ID) is associated with sleep disorders, but standardized assessment of iron status in the diagnostic work-up and iron supplementation as treatment have not been considered in clinical practice. We investigated associations of ID with type and severity of sleep disorders and whether iron supplementation improves sleep-related symptoms. In 2017, we conducted a scoping review for the period 1972-2016 using the terms "iron deficiency anemia" and "sleep" on biomedical database search engines, and in 2019, we updated our review with an ad-hoc search. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.smrv.2020.101274DOI Listing