5,437 results match your criteria Restless Legs Syndrome

The Effect of Cannabidiol for Restless Legs Syndrome/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A Exploratory Analysis of Phase 2/3 Clinical Trial.

Cannabis Cannabinoid Res 2022 Jun 24. Epub 2022 Jun 24.

Division of Neurology, Department of Neuroscience and Sciences of Behavior, Faculty of Medicine, University of São Paulo, Ribeirão Preto, Brazil.

Cannabidiol (CBD) is one of the main nonpsychoactive components of and may represent an alternative treatment for Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) in patients with Parkinson's disease (PD) and REM (Rapid Eye Movement) sleep behavior disorder (RBD). Our purpose was a exploratory analysis to evaluate the CBD's efficacy to improve the severity of RLS/WED symptoms in patients with PD and RBD. A exploratory analysis of a phase II/III, a parallel, double-blind, placebo-controlled clinical trial was conducted in 18 patients with RLS/WED and PD plus RBD associated. Read More

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Improved definition of growing pains: A common familial primary pain disorder of early childhood.

Paediatr Neonatal Pain 2022 Jun 7;4(2):78-86. Epub 2022 May 7.

Twins Research Australia, Centre for Epidemiology and Biostatistics School of Population and Global Health University of Melbourne Melbourne Victoria Australia.

Background: Commonly applied diagnostic criteria for growing pains (GP) have evolved without determination by an authoritative representative body. GP and restless legs syndrome (RLS) share anatomical, distributional, temporal, and other clinical features and are associated in individuals over time, in families, and in population samples. In this study, we tested the hypothesis that GP, diagnosed by widely used criteria, is confounded by cases of painful restless legs syndrome (RLS-Painful). Read More

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Hyperhidrosis in sleep disorders - A narrative review of mechanisms and clinical significance.

J Sleep Res 2022 Jun 15:e13660. Epub 2022 Jun 15.

Laboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Hyperhidrosis is characterized by excessive sweating beyond thermoregulatory needs that affects patients' quality of life. It results from an excessive stimulation of eccrine sweat glands in the skin by the sympathetic nervous system. Hyperhidrosis may be primary or secondary to an underlying cause. Read More

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[Gambling addiction as a side effect of low dose pramipexole in the treatment of restless legs syndrome].

Ugeskr Laeger 2022 Jun;184(24)

Neurologisk Afdeling, Københavns Universitetshospital - Bispebjerg Hospital.

Pathologic gambling is a rare but severe side effect of dopamine agonists (DA). Low dosage DA, as given when treating restless legs syndrome (RLS), has been thought only to have mild side effects. This case report describes two patients with low dosage pramipexole for RLS, who developed gambling addiction for a decade, highly affecting their quality of life. Read More

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Restless Sleep Disorder (RSD): a New Sleep Disorder in Children. A Rapid Review.

Curr Neurol Neurosci Rep 2022 Jun 14. Epub 2022 Jun 14.

Department of Developmental and Social Psychology, Sapienza University, Via dei Marsi 78, 00185, Rome, Italy.

Purpose Of Review: Restless sleep disorder (RSD) is a recently identified pediatric sleep disorder characterized by frequent movements during sleep associated with daytime symptoms. In this review we summarize the expanding evidence of the clinical presentation of RSD, potential pathophysiology, associated comorbidities, and current treatment options that will help the pediatrician identify children with RSD in a timely manner.

Recent Findings: RSD is diagnosed in 7. Read More

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Validation and Diagnostic Accuracy of Hindi Restless Legs Syndrome (RLS-H) Screening Tool.

J Neurosci Rural Pract 2022 Apr 10;13(2):307-314. Epub 2022 Mar 10.

Department of Neurology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.

 Restless legs syndrome (RLS), a prevalent and treatable entity, has high impact on quality of life, requiring a better screening tool for its early detection. Thus, present study aimed to derive a Hindi RLS (RLS-H) screening tool for its use in Indian population.  RLS-H screening tool, derived by translating first four criteria of 2012 revised International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria in Hindi and was validated in 50 RLS and 50 non-RLS patients. Read More

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Comparison of the Effect of Reflexology and Swedish Massage on Restless Legs Syndrome and Sleep Quality in Patients Undergoing Hemodialysis: a Randomized Clinical Trial.

Int J Ther Massage Bodywork 2022 Jun 1;15(2):1-13. Epub 2022 Jun 1.

Department of Medical-Surgical Nursing, Faculty of Nursing & Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Patients undergoing hemodialysis experience painful complications such as restless leg syndrome and poor sleep quality, which negatively affect their quality of life.

Purpose: This study aimed to compare the effect of reflexology and Swedish massage on restless leg syndrome and sleep quality in patients undergoing hemodialysis.

Method: This is a randomized clinical trial conducted on 90 patients undergoing hemodialysis. Read More

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Treatment of Depression with Vortioxetine in a Patient with Comorbid Major Depressive Disorder and Restless Legs Syndrome: A Case Report.

Barış Yilbaş

Noro Psikiyatr Ars 2022 28;59(2):164-166. Epub 2022 Apr 28.

Sanko University School of Medicine, Department of Psychiatry, Gaziantep, Turkey.

Many case reports have shown that the use of antidepressants can lead to restless legs syndrome (RLS). Vortioxetine is a new generation antidepressant with a multimodal mechanism of action on serotonin receptors. In this case report, partial improvement in RLS symptoms after treatment with vortioxetine in a patient with a co-diagnosis of major depressive disorder and restless legs syndrome will be discussed. Read More

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Prevalence And Predictors of Restless Leg Syndrome in Adolescent and Young Adults in Bengaluru City, India - a Cross Sectional Study.

Neuroepidemiology 2022 Jun 7. Epub 2022 Jun 7.

Introduction: Restless leg syndrome (RLS) is a sensorimotor disease characterized by an urge to move the legs, often caused by uncomfortable and unpleasant sensations in the legs. It affects the quality of sleep which in turn affects scholastic performance in children and predisposes them to cardiovascular diseases in the long run. Hence, the primary aim of this study was to assess the prevalence and predictors of RLS, poor sleep quality and excessive daytime sleepiness (EDS) Methods: This was a cross sectional observational study conducted between September 2017 and March 2020 in Bengaluru, India including all consenting Pre - university college, Degree college, and Higher secondary school students. Read More

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Advanced network neuroimaging as an approach to unravel the pathophysiology of restless legs syndrome.

Jan Kassubek

Sleep 2022 Jun 3. Epub 2022 Jun 3.

Department of Neurology, University of Ulm, Ulm, Germany.

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Neurodegenerative Disorders and Sleep.

Raman K Malhotra

Sleep Med Clin 2022 Jun 22;17(2):307-314. Epub 2022 Apr 22.

Washington University Sleep Medicine Center, Department of Neurology, Washington University in St. Louis School of Medicine, 1600 S. Brentwood Boulevard, #600, St. Louis, MO 63144, USA. Electronic address:

Patients suffering from neurodegenerative conditions frequently report sleep complaints, such as insomnia and excessive daytime sleepiness. These symptoms are likely multifactorial, caused by their underlying neurologic disorder and also by medications and other comorbidities associated with the progressive condition. A detailed history, sleep logs, actigraphy, or polysomnography may be necessary to properly diagnosis and manage these patients. Read More

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Parasomnias and Sleep-Related Movement Disorders in Older Adults.

Alex Iranzo

Sleep Med Clin 2022 Jun 22;17(2):295-305. Epub 2022 Apr 22.

Neurology Service, Hospital Clinic de Barcelona, C/ Villarroel 180, Barcelona 08036, Spain. Electronic address:

Sleep paralysis is rare in the elderly but may occur particularly in families suffering from this phenomenon. In a minority of patients with disorders of arousal, the episodes persist until the age of 70. Zolpidem and other medications may induce sleepwalking and sleep eating-related syndrome. Read More

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Sleep Deficiency, Sleep Apnea, and Chronic Lung Disease.

Clin Chest Med 2022 Jun;43(2):337-352

Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, 9300 Campus Point Drive, La Jolla, CA 92037, USA. Electronic address:

With sleep occupying up to one-third of every adult's life, addressing sleep is essential to overall health. Sleep disturbance and deficiency are common in patients with chronic lung diseases and associated with worse clinical outcomes and poor quality of life. A detailed history incorporating nocturnal respiratory symptoms, symptoms of obstructive sleep apnea (OSA) and restless legs syndrome, symptoms of anxiety and depression, and medications is the first step in identifying and addressing the multiple factors often contributing to sleep deficiency in chronic lung disease. Read More

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Sleep Quality in Neuromyelitis Optica Spectrum Disorder: A Systematic Review.

Int J MS Care 2022 May-Jun;24(3):124-131. Epub 2021 Aug 18.

Department of Ophthalmology and Vision Sciences (KZ, EM), University of Toronto, Toronto, ON, Canada.

Background: This review summarizes the literature on sleep quality in neuromyelitis optica spectrum disorder (NMOSD) and discusses these findings in the context of current knowledge of sleep physiology.

Methods: A literature search was performed using Ovid MEDLINE, Embase, and Scopus from inception to September 3, 2020. All included studies reported at least 1 measure of sleep quality in individuals with NMOSD. Read More

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The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis.

Healthcare (Basel) 2022 Apr 28;10(5). Epub 2022 Apr 28.

Department 5, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Introduction And Aim: Sleep disorders are highly prevalent in patients with liver cirrhosis. The aim of this study was to investigate the prevalence of restless legs syndrome (RLS), as well as its risk factors and possible predictors, in a cohort of patients with liver cirrhosis.

Material And Methods: We performed a cross-sectional prospective study over a period of 14 months and enrolled 69 patients with liver cirrhosis, after applying the inclusion and exclusion criteria. Read More

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Is There a Place for Medicinal Cannabis in Treating Patients with Sleep Disorders? What We Know so Far.

Nat Sci Sleep 2022 18;14:957-968. Epub 2022 May 18.

West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology & Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

The legalization of cannabis for medicinal, and in some countries, recreational, purposes in addition to growth in the cannabis industry has meant that cannabis use and interest in the area has increased rapidly over the past 20 years. Treatment of poor sleep and sleep disorders are two of the most common reasons for the current use of medicinal cannabis. However, evidence for the role of medical cannabis in the treatment of sleep disorders has not been clearly established, thus making it challenging for clinicians to make evidence-based decisions regarding efficacy and safety. Read More

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Treatment initiation and utilization patterns of pharmacotherapies for early-onset idiopathic restless legs syndrome.

Sleep Med 2022 Aug 13;96:70-78. Epub 2022 May 13.

Department of Pharmaceutical Outcomes & Policy, University of Florida, College of Pharmacy, 1225 Center Drive, Gainesville, FL, 32610-0496, USA; Center for Drug Evaluation & Safety, Department of Pharmaceutical Outcomes & Policy, University of Florida, College of Pharmacy, 1225 Center Drive, Gainesville, FL, 32610-0496, USA. Electronic address:

Objective/background: Restless legs syndrome (RLS) is a complex condition associated with circadian rhythm that disrupts sleep and can cause multisystemic consequences. This study assesses pharmacotherapy treatment initiation, estimates annual treatment prevalence, and assesses treatment patterns for early-onset idiopathic RLS.

Methods: We used the MarketScan Commercial Claims Database from 2012 to 2019 to conduct a new user retrospective cohort study. Read More

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A case of restless legs syndrome after BNT162b2 mRNA COVID-19 vaccination.

Neurol Clin Neurosci 2022 May 26;10(3):178-180. Epub 2022 Mar 26.

Shinya Clinic Chigasaki Japan.

Restless legs syndrome (RLS) can be secondary to several disorders. We present an 87-year-old woman who developed RLS 2 days after the first injection of BNT162b2 mRNA coronavirus disease 2019 vaccine. The symptoms of RLS tended to improve and eventually resolved with the administration of gabapentin. Read More

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Alterations of Functional Connectivity in Patients With Restless Legs Syndrome.

J Clin Neurol 2022 May;18(3):290-297

Department of Neurology, Keimyung University School of Medicine, Daegu, Korea.

Restless legs syndrome (RLS) is a common neurological illness marked by a strong desire to move one's legs, usually in association with uncomfortable sensations. Recent studies have investigated brain networks and connectivity in RLS. The advent of network analysis has greatly improved our understanding of the brain and various neurological disorders. Read More

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Obesity effects on sleep quality with anthropometric and metabolic changes.

Rev Assoc Med Bras (1992) 2022 May;68(5):574-578

Sisli Hamidiye Etfal Training and Research Hospital, Otolaryngology Department - Istanbul, Turkey.

Objective: Obesity is one of the etiological factors of sleep disorders (e.g., obstructive sleep apnea and restless leg syndrome). Read More

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Management and Treatment of Grover's Disease: A Case Report and Review of Literature.

Cureus 2022 Apr 12;14(4):e24082. Epub 2022 Apr 12.

Family Medicine, Lake Erie College of Osteopathic Medicine, Jacksonville, USA.

This case report details a rare case of Grover's disease in an 80-year-old Caucasian male complaining of a rash across his chest over the last three to four months. The patient has a past medical history of essential hypertension, hyperlipidemia, osteoarthritis of the knee, chronic gastroesophageal reflux disease (GERD), supraventricular tachycardia, status post prostate cancer, and restless legs syndrome. During his initial evaluation, he was found to have a pruritic, erythematous, papular rash most notably along his upper trunk and chest. Read More

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Sleep Quality among Patients with Type 2 Diabetes: A Cross-Sectional Study in the East Coast Region of Peninsular Malaysia.

Int J Environ Res Public Health 2022 04 25;19(9). Epub 2022 Apr 25.

Department of Family Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Kuantan 25200, Malaysia.

Poor sleep is related to type 2 diabetes and adversely influences a person's quality of life. This study aimed to evaluate sleep quality in patients with type 2 diabetes (T2DM), its associated factors, and its relationship with quality of life. A cross-sectional study was conducted at a primary care clinic in a tertiary hospital on the east coast of Malaysia. Read More

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Detection of Parent-of-Origin Effects for the Variants Associated With Behavioral Disinhibition in the MCTFR Data.

Front Genet 2022 26;13:831685. Epub 2022 Apr 26.

Department of Biostatistics, State Key Laboratory of Organ Failure Research, Ministry of Education, and Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.

Behavioral disinhibition is one of the important characteristics of many mental diseases. It has been reported in literature that serious behavioral disinhibition will affect people's health and greatly reduce people's quality of life. Meanwhile, behavioral disinhibition can easily lead to illegal drug abuse and violent crimes, etc. Read More

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The conundrum of the origin of restless legs syndrome.

Wei-Sheng Lin

Sleep 2022 05 2;45(5). Epub 2022 Feb 2.

Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan.

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Striatal mechanism of the restless legs syndrome.

Sleep 2022 May 10. Epub 2022 May 10.

Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles. California, USA.

Study Objectives: Brain iron deficiency has been reported to be associated with the restless legs syndrome (RLS). However, 30%-50% of RLS patients do not respond to iron therapy, indicating that mechanisms other than brain iron deficiency may also participate in this disease. The striatum is known to be involved in the modulation of motor activity. Read More

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How Effective Are Treatment Guidelines for Augmented RLS?

Sleep 2022 May 9. Epub 2022 May 9.

Massachusetts General Hospital, One Bowdoin Square, 10th Floor, Boston, MA 02114, USA.

Study Objectives: The objective of this study was to assess the effectiveness of current treatment guidelines for RLS augmentation in patients on dopamine agonists (DA) which recommend a cross-titration strategy to an alpha-2-delta ligand (A2D) and/or opioid.

Methods: Consecutive new consultations for RLS with both augmentation and active treatment with a dopamine agonist at the time of initial assessment were included if followed >5 months. Clinical information from the semi-structured initial consultation, and subsequent visits until their most recent/final visit was extracted. Read More

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Unilateral Poststroke Periodic Limb Movements: A Case Series.

Case Rep Neurol 2022 Jan-Apr;14(1):162-166. Epub 2022 Mar 21.

Department of Neurology, E. Agnelli ASL TO3 Hospital, Pinerolo, Italy.

Periodic limb movements (PLM) and restless leg syndrome (RLS) are involuntary common sleep-related movements which often hamper sleep onset; they are mostly idiopathic and bilateral but are seldom described secondary after a stroke. These cases are rare, often unilateral, and because of the usually transitory duration of symptoms, often under-recognized. When a treatment is required, it can be tricky and the drug choice not foregone. Read More

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Middle Mediastinal Mass Compressing the Pulmonary Trunk in a Patient With a History of Breast Cancer.

Chest 2022 May;161(5):e265-e272

Department of Medicine, Division of Respirology, Queen's University, Kingston, ON, Canada. Electronic address:

Case Presentation: A 61-year-old White woman, nonsmoker, was referred to Respirology for evaluation of small pulmonary nodules discovered incidentally on surveillance imaging 3 years after breast cancer treatment. She had a remote left breast ductal carcinoma in situ treated with lumpectomy followed by radiation therapy, and recurrent stage 1 breast cancer (estrogen receptor/progesterone receptor-positive, human epidermal growth factor receptor 2-negative) treated with mastectomy, axillary lymph node dissection, and reconstructive surgery, followed with adjuvant chemotherapy, radiation therapy, and letrozole maintenance. Her other medical conditions included compensated cirrhosis secondary to nonalcoholic fatty liver disease, type 2 diabetes, hypertension, OSA, restless legs syndrome, obesity, anxiety, and depression. Read More

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Sleep disorders among Aboriginal Australians with Machado-Joseph Disease: Quantitative results from a multiple methods study to assess the experience of people living with the disease and their caregivers.

Neurobiol Sleep Circadian Rhythms 2022 May 22;12:100075. Epub 2022 Apr 22.

Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, 105 Rocklands Drive, Tiwi, Northern Territory, 0810, Australia.

Background: Machado-Joseph Disease (MJD), or Spinocerebellar Ataxia Type 3 (SCA3), is a genetic disorder that causes progressive muscle weakness, loss of motor control, ataxia and permanent physical disability. Sleep disturbances are associated with MJD but remain poorly understood.

Objective: To investigate frequency and characteristics of sleep disorders and their association with health-related quality of life and psychosocial wellbeing for Aboriginal Australians living with MJD. Read More

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Voxel-wise lesion mapping of restless legs syndrome in multiple sclerosis.

Neurol Sci 2022 May 5. Epub 2022 May 5.

Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054, Erlangen, Germany.

Objective: Restless legs syndrome (RLS) is known to be associated with multiple sclerosis (MS) and may be caused by MS lesions in specific cerebral brain regions. Applying a voxel-wise lesion analysis, we tried to identify the contribution of cerebral MS lesions to RLS.

Methods: In this retrospective study, we established a cohort of people with MS with documented RLS and controls of people with MS without RLS matched disease severity. Read More

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