5,182 results match your criteria Restless Legs Syndrome

Randomized, placebo-controlled trial of ferric carboxymaltose in restless legs syndrome patients with iron deficiency anemia.

Sleep Med 2021 Jun 19;84:179-186. Epub 2021 Jun 19.

Department of Neurology, Johns Hopkins University, Hopkins Bayview Medical Center, Baltimore, MD, USA.

Objective: Intravenous ferric carboxymaltose (FCM) has been shown to be efficacious in treating restless legs syndrome (RLS) symptoms in non-anemic patients. The aim of this study was to evaluate the effectiveness of FCM in treating RLS symptoms in patients who also had an iron deficiency anemia (IDA).

Methods: This is a randomized, double-blinded, placebo-controlled study. Read More

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Restless legs syndrome and headache cause sleepiness and consequent poor school performance: a community based study from Turkey.

Minerva Pediatr (Torino) 2021 Jun 21. Epub 2021 Jun 21.

Department of Public Health, Faculty of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey.

Background: Disturbance of sleep habits leads to excessive daytime sleepiness (EDS), which may affect learning abilities and consequently academic performance. Therefore the main purpose of current paper was to determine the prevalence of headache and Restless legs syndrome (RLS) in school-aged adolescents and to evaluate the type of headache in adolescents, with a secondary aim to determine the effect of daytime sleepiness on academic success.

Methods: This cross-sectional study was conducted on adolescents aged between 15 and 19 years of age, who were in high school education in the 2016-2017 academic years in Kahramanmaraş province. Read More

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[Insomnia in the context of neurological diseases].

Moritz D Brandt

Fortschr Neurol Psychiatr 2021 Jun 18;89(6):314-328. Epub 2021 Jun 18.

This article provides an overview of the prevalence, cause and treatment of insomnia in common neurological diseases (restless legs syndrome, stroke, multiple sclerosis, Parkinson´s disease and Alzheimer´s disease) with an additional focus on the bidirectional relationship between sleep and neurological disorders.Insomnia is prevalent, but frequently unrecognized in the context of neurological diseases. Although it is widely known that sleep has a relevant impact on quality of life in general and cerebral function in particular, sleep disorders receive little attention in the prevention and treatment of neurological diseases. Read More

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A Randomized, Placebo-Controlled Crossover Study with Dipyridamole for Restless Legs Syndrome.

Mov Disord 2021 Jun 17. Epub 2021 Jun 17.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA.

Background: New pharmacological targets are needed for restless legs syndrome. Preclinical data suggest that a hypoadenosinergic state plays an important pathogenetic role.

Objective: The objective of this study was to determine whether inhibitors of equilibrative nucleoside transporters, for example, dipyridamole, could provide effective symptomatic treatment. Read More

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[Transcranial sonographic characteristics of Parkinson's disease with symptoms of restless legs syndrome].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(21):1566-1571

Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

To evaluate the transcranial sonographic characteristics in patients with Parkinson's disease (PD) with symptoms of restless legs syndrome (RLS). Patients with diagnosis of definite PD from the Second Affiliated Hospital of Soochow University and 3 other participating hospitals between September 2018 and December 2019 were consecutively enrolled. Concurrent RLS symptoms were determined using Non-motor Symptoms Questionnaire. Read More

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Restless legs syndrome in systemic lupus erythematosus: A case-control study.

Exp Ther Med 2021 Aug 26;22(2):802. Epub 2021 May 26.

Department of Neurology, Faculty of Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania.

Sleep disturbances in systemic lupus erythematosus (SLE) are not well understood. The restless legs syndrome (RLS) is one of the frequent occurring sleep disturbances in SLE. The aim of this study was to evaluate the prevalence of RLS and its characteristics in SLE. Read More

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Restless legs-like syndrome as an emergent adverse event of CGRP monoclonal antibodies: A report of two cases.

Cephalalgia 2021 Jun 4:3331024211017879. Epub 2021 Jun 4.

Service of Neurology, University Hospital Marqués de Valdecilla, University of Cantabria and IDIVAL, Santander, Spain.

Background: One of the advantages of CGRP monoclonal antibodies is their excellent safety and tolerability. However, postmarketing surveillance, is essential to detect potential rare emergent adverse events.

Objectives: To report two patients who developed restless legs syndrome symptoms after treatment with CGRP antibodies. Read More

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[Self-reported sleep and wake disorders in patients with ostheoarthrosis and end-stage renal disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):80-91

Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, St. Petersburg, Russia.

Objective: This study aimed to assess subjective sleep and wake disorders (SWD) in patients with osteoarthritis and comorbid end-stage renal disease (ESRD) receiving hemodialysis (ESRD-HD) compared to patients with osteoarthritis and without chronic kidney disease (CKD) as well as to clarify of the association of subjective sleep characteristics with the levels of anxiety and depression and pain, general health score and laboratory parameters in these cohorts.

Material And Methods: This pilot case-control study included the patients with stage III hip osteoarthritis with ESRD-HD (=19) and without CKD (=19) aged 18-85 years. The patients received the consultations of orthopedic surgeon and internal medicine specialist with anthropometry and clinical and biochemical blood tests. Read More

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[Features of the organization of sleep in children with attention deficit hyperactivity disorder].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4. Vyp. 2):55-60

The First Medical and Pedagogical Center «Lingua Bona», Perm, Russia.

The article presents modern ideas about the clinical features of sleep in children with attention deficit hyperactivity disorder (ADHD), the macrostructure of sleep, its cyclic organization and possible common links in the pathogenesis of sleep disorders and behavioral problems in patients. The relationship between the structure of sleep and impaired executive functions, the level of social maladjustment in patients with ADHD has been proven. Typical of children with ADHD are difficulty in going to sleep and falling asleep for a long time (resistance to sleep time), increased motor activity associated with sleep, including the association of ADHD with Restless legs syndrome (RLS) and periodic leg movement syndrome (PLMS), daytime sleepiness. Read More

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Sleep disorders in Wilson's disease.

Sleep Med 2021 Jul 30;83:299-303. Epub 2020 Aug 30.

French National Reference Centre for Wilson's Disease, Foundation Rothschild Hospital, Paris, France; Neurology Department, Foundation Rothschild Hospital, Paris, France.

Background/objectives: Wilson's disease (WD) is a rare genetic disorder that leads to copper overload, mainly in the liver then, in the brain. Patients with WD often complain about sleep disorders. We aimed to explore them. Read More

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Acetyl-DL-leucine improves restless legs syndrome: a case report.

J Neurol 2021 Jul 30;268(7):2595-2596. Epub 2021 May 30.

Department of Neurology, Hospital of the Ludwig-Maximilians University, Munich, Germany.

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Effects of insomnia and restless legs syndrome on sleep arterial blood pressure: A systematic review and meta-analysis.

Sleep Med Rev 2021 Apr 30;59:101497. Epub 2021 Apr 30.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Hypertension and blunted blood pressure (BP) dipping during nighttime sleep are associated with increased cardiovascular risk. Chronic insomnia and restless legs syndrome (RLS) may affect the 24-h BP profile. We systematically reviewed the association of insomnia and RLS with BP values during nighttime sleep and the relative BP dipping pattern. Read More

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The Impact of Subthalamic Deep Brain Stimulation on Restless Legs Syndrome in Parkinson's Disease.

Neuromodulation 2021 May 25. Epub 2021 May 25.

Department of Neurological and Psychiatric Nursing, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland.

Introduction: The study aimed at evaluating the effect of subthalamic deep brain stimulation (DBS-STN) on restless legs syndrome (RLS) in Parkinson's disease (PD) patients.

Materials And Methods: We assessed the presence of RLS before, 6 and 12 months after surgery in 36 patients. Differences between patients with RLS, without RLS, and with remission of RLS in terms of sleep measures (interview and validated questionnaires) and nonmotor symptoms (NMS). Read More

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Challenges in the Treatment of Restless Legs Syndrome: A Case Report.

J Prim Care Community Health 2021 Jan-Dec;12:21501327211019590

Mayo Clinic, Rochester, MN, USA.

Treatment resistant restless legs syndrome (RLS) in the setting of psychiatric comorbidities can be difficult to manage. Our patient is a 69-year-old Caucasian gentleman with bipolar disorder type I, unspecified anxiety disorder, obstructive sleep apnea (OSA), and treatment-refractory RLS. At initial presentation, the patient's prescribed medication regimen included fluoxetine 40 mg daily, gabapentin 800 mg in the morning and 3200 mg at bedtime, pramipexole 0. Read More

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Clinical Decision-Making: Restless Legs Syndrome and Dementia in Older Adults.

Nurs Clin North Am 2021 Jun;56(2):265-274

The University of Texas at Austin, School of Nursing, 1712 Red River Street, Austin, TX 78712, USA. Electronic address: https://twitter.com/phdb4ss.

Restless legs syndrome (RLS), one of the more prevalent sleep disturbances among older adults, impacts quality of life. Patients with dementia are at high risk for developing RLS and may be unable to describe their symptoms. Often underdiagnosed, RLS can contribute to discomfort, pain, nighttime agitation, disturbed sleep, and falls. Read More

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The Social And Economic Cost Of Sleep Disorders.

Sleep 2021 May 20. Epub 2021 May 20.

Centre for Sleep Science, University of Western Australia, Perth, Australia.

Study Objectives: To estimate economic cost of common sleep disorders in Australia for 2019-2020.

Methods: Costs were estimated for obstructive sleep apnea (OSA), insomnia, and restless legs syndrome (RLS) using prevalence, financial, and nonfinancial data from national databases. These included: (1) financial costs associated with health care, informal care, productivity losses, non-medical accident costs, deadweight loss from taxation/welfare inefficiencies; and (2) nonfinancial costs associated with loss of well-being. Read More

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Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.

J Sleep Res 2021 May 18:e13311. Epub 2021 May 18.

Institute of Genetics and Molecular and Cellular Biology, CNRS UMR7104, INSERM U1258, University of Strasbourg, Illkirch, France.

Restless legs syndrome (RLS) is a common neurological disorder in which sensorimotor symptoms lead to sleep disturbances with substantial impact on life quality. RLS is caused by a combination of genetic and environmental factors, and Meis homeobox 1 (MEIS1) was identified as the main genetic risk factor. The efficacy of dopaminergic agonists, including dopamine D receptor (DRD2) agonists, for treating RLS led to the hypothesis of dopaminergic impairment. Read More

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Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease.

Curr Neuropharmacol 2021 May 16. Epub 2021 May 16.

Department of Neurology, Shanghai TongRen Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336. China.

Sleep disorders are one of the most common non-motor symptoms in Parkinson's disease (PD). It can cause a notably decrease in quality of life and functioning in PD patients, as well as place a huge burden on both patients and caregivers. The most cited sleep disorders in PD included insomnia, restless legs syndrome (RLS), rapid eye movement (REM) sleep behavior disorders (RBD), excessive daytime sleepiness (EDS) and sleep disordered breathing (SDB), which can appear alone or several at the same time. Read More

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Restless Legs Syndrome Shows Increased Silent Postmortem Cerebral Microvascular Disease With Gliosis.

J Am Heart Assoc 2021 Jun 15;10(11):e019627. Epub 2021 May 15.

Sleep Division Department of Neurology Vanderbilt University Medical Center Nashville TN.

Background Patients with restless legs syndrome (RLS) have increased silent microvascular disease by magnetic resonance imaging. However, there has been no previous autopsy confirmation of these magnetic resonance imaging findings. RLS is also frequently associated with inflammatory and immunologically mediated medical disorders. Read More

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Pediatric Restless Legs Syndrome.

Sleep Med Clin 2021 Jun 10;16(2):305-314. Epub 2021 Apr 10.

Seattle Children's Hospital, OC.7.720 - Pulmonary, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.

Early-onset restless legs syndrome has a relatively high prevalence in pediatrics, is highly familial, and is often preceded by a diagnosis of periodic limb movement disorder or childhood insomnia. Diagnostic criteria are derived but not equal to those of the adult syndrome and are adapted according to children's age and linguistic competence. Diagnosis requires parents or caregivers to participate; video-polysomnographic nocturnal recording, although not mandatory, may help confirm dubious cases. Read More

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The Long-Term Psychiatric and Cardiovascular Morbidity and Mortality of Restless Legs Syndrome and Periodic Limb Movements of Sleep.

Sleep Med Clin 2021 Jun 15;16(2):279-288. Epub 2021 Apr 15.

Sleep Disorders Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, One Bowdoin Square, 10th Floor, Boston, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:

Restless legs syndrome (RLS) is a sensory-motor neurological disorder that is associated with high levels of distress and sleep disturbance. Cross-sectional and longitudinal evidence suggests that individuals suffering from RLS may be at an increased risk of certain psychiatric illnesses and cardiovascular diseases. There also is evidence for increased mortality rates in RLS patients, although contrasting results do exist. Read More

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Restless Legs Syndrome: Challenges to Treatment.

Sleep Med Clin 2021 Jun 15;16(2):269-277. Epub 2021 Apr 15.

Sleep Research Institute, Calle Padre Damián 44 Madrid 28036, Spain. Electronic address:

For a long time, dopaminergic treatment (DT) was the medication for restless legs syndrome. Although DT is effective and safe over the short-term, complications develop over longer periods, including augmentation, tolerance, and impulse control disorders. Nowadays, it is recommended that first-line treatment should be alpha-2 ligands, which are more effective in the absence of previous DT. Read More

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Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.

Sleep Med Clin 2021 Jun 10;16(2):249-267. Epub 2021 Apr 10.

Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

Akathisia is an urgent need to move that is associated with treatment with dopamine receptor blocking agents (DRBAs) and with restless legs syndrome (RLS). The pathogenetic mechanism of akathisia has not been resolved. This article proposes that it involves an increased presynaptic dopaminergic transmission in the ventral striatum and concomitant strong activation of postsynaptic dopamine D receptors, which form complexes (heteromers) with dopamine D and adenosine A receptors. Read More

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Restless Legs Syndrome - Clinical Features.

Sleep Med Clin 2021 Jun 24;16(2):233-247. Epub 2021 Apr 24.

Sleep Research Institute, Calle del Padre Damián, 44, Madrid 28036, Spain; Sleep Unit, Respiratory Department, Hospital Ramón y Cajal, IRYCIS, CIBERES, Madrid, Spain.

Restless legs syndrome (RLS) is one of the most common neurologic conditions, with an estimated prevalence in European and North American heritage populations of about 2% to 5%. Because RLS diagnosis is essentially clinical, a careful evaluation of the symptoms is mandatory. It is important to exclude RLS mimics and evaluate factors that could exacerbate RLS symptoms. Read More

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The Clinical Evaluation of Sleep-Related Movement Disorders.

Sleep Med Clin 2021 Jun 18;16(2):223-231. Epub 2021 Apr 18.

Sleep Unit, Sleep Research Institute, Calle Padre Damián 44 Madrid 28036, Spain. Electronic address:

This article is a comprehensive review of the clinical evaluation of sleep-related movement disorders. In this review, the authors present a practical approach to help clinicians identify the "pattern recognition" of movement and behavior disorders during sleep, with the process of translating a particular movement that occurs when asleep, with clinically classifying disorders, and with obtaining an etiologic diagnosis. The aim is not to provide an exhaustive review of the literature, but to concentrate on the most important symptoms, so the clinical approach can be improved and the best choices can be made during the diagnostic process. Read More

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Irritable bowel syndrome, restless legs syndrome, small fiber neuropathy, and fibromyalgia.

Franco Gemignani

Sleep Med 2021 Jul 24;83. Epub 2021 Apr 24.

University of Parma, Italy. Electronic address:

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Phenotypical predictors of pregnancy-related restless legs syndrome and their association with basal ganglia and the limbic circuits.

Sci Rep 2021 May 11;11(1):9996. Epub 2021 May 11.

Parietal Team, INRIA, CEA, Université Paris-Saclay, 3 rue Joliot-Curie, 91192, Gif-sur-Yvette, France.

Restless legs syndrome (RLS) in pregnancy is a common disorder with a multifactorial etiology. A neurological and obstetrical cohort of 308 postpartum women was screened for RLS within 1 to 6 days of childbirth and 12 weeks postpartum. Of the 308 young mothers, 57 (prevalence rate 19%) were identified as having been affected by RLS symptoms in the recently completed pregnancy. Read More

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Idiopathic and secondary restless legs syndrome during pregnancy in Japan: Prevalence, clinical features and delivery-related outcomes.

PLoS One 2021 11;16(5):e0251298. Epub 2021 May 11.

Sleep Apnea Center, Kyushu University Hospital, Fukuoka, Japan.

Objective: The aim of this study was to investigate prevalence of idiopathic and secondary restless legs syndrome (RLS) according to pregnancy trimester, and its effects on delivery-related outcomes among pregnant women in Japan.

Methods: This was a single-center, prospective observational study. One hundred eighty-two consecutive pregnant women participated in the study from June 2014 to March 2016. Read More

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Lack of Causal Effects or Genetic Correlation between Restless Legs Syndrome and Parkinson's Disease.

Mov Disord 2021 May 11. Epub 2021 May 11.

Department of Human Genetics, McGill University, Montréal, Québec, Canada.

Background: Epidemiological studies have reported an association between Parkinson's disease (PD) and restless legs syndrome.

Objectives: We aimed to use genetic data to study whether these 2 disorders are causally linked or share genetic architecture.

Methods: We performed two-sample Mendelian randomization and linkage disequilibrium score regression using summary statistics from recent genome-wide meta-analyses of PD and restless legs syndrome. Read More

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Clinical characteristics of periodic limb movements during sleep categorized by continuous positive airway pressure titration polysomnography in patients with obstructive sleep apnea.

Sleep Breath 2021 May 10. Epub 2021 May 10.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.

Purpose: The presence of periodic limb movements during sleep (PLMS) varies among patients with obstructive sleep apnea (OSA) undergoing treatment with continuous positive airway pressure (CPAP). The factors associated with this variation are unknown.

Methods: PLMS were defined as a periodic leg movements index of > 15/h. Read More

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